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Protein

FERM domain-containing protein 4B

Gene

FRMD4B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
FERM domain-containing protein 4B
Alternative name(s):
GRP1-binding protein GRSP1
Gene namesi
Name:FRMD4B
Synonyms:KIAA1013
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:24886. FRMD4B.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-KW
  • cytoskeleton Source: UniProtKB-SubCell
  • extracellular space Source: UniProtKB
  • ruffle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394605.

Polymorphism and mutation databases

BioMutaiFRMD4B.
DMDMi332278248.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10341034FERM domain-containing protein 4BPRO_0000219446Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei372 – 3721PhosphoserineBy similarity
Modified residuei608 – 6081PhosphoserineCombined sources
Modified residuei697 – 6971PhosphoserineBy similarity
Modified residuei915 – 9151PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y2L6.
MaxQBiQ9Y2L6.
PaxDbiQ9Y2L6.
PRIDEiQ9Y2L6.

PTM databases

iPTMnetiQ9Y2L6.
PhosphoSiteiQ9Y2L6.

Expressioni

Gene expression databases

BgeeiQ9Y2L6.
CleanExiHS_FRMD4B.
ExpressionAtlasiQ9Y2L6. baseline and differential.
GenevisibleiQ9Y2L6. HS.

Organism-specific databases

HPAiHPA009705.

Interactioni

Subunit structurei

Interacts with GRP1.By similarity

Protein-protein interaction databases

BioGridi116765. 1 interaction.
IntActiQ9Y2L6. 1 interaction.
MINTiMINT-2823146.
STRINGi9606.ENSP00000381549.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2L6.
SMRiQ9Y2L6. Positions 68-458.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini59 – 361303FERMPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili417 – 45034Sequence analysisAdd
BLAST
Coiled coili531 – 56131Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 FERM domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3529. Eukaryota.
ENOG410XQFP. LUCA.
GeneTreeiENSGT00830000128251.
HOGENOMiHOG000294161.
HOVERGENiHBG062800.
InParanoidiQ9Y2L6.
OMAiNEYRIRC.
PhylomeDBiQ9Y2L6.
TreeFamiTF328984.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR021774. DUF3338.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR011993. PH_dom-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF11819. DUF3338. 1 hit.
PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
[Graphical view]
PRINTSiPR00935. BAND41.
SMARTiSM00295. B41. 1 hit.
SM01196. FERM_C. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y2L6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASVFMCGVE DLLFSGSRFV WNLTVSTLRR WYTERLRACH QVLRTWCGLQ
60 70 80 90 100
DVYQMTEGRH CQVHLLDDRR LELLVQPKLL ARELLDLVAS HFNLKEKEYF
110 120 130 140 150
GITFIDDTGQ QNWLQLDHRV LDHDLPKKPG PTILHFAVRF YIESISFLKD
160 170 180 190 200
KTTVELFFLN AKACVHKGQI EVESETIFKL AAFILQEAKG DYTSDENARK
210 220 230 240 250
DLKTLPAFPT KTLQEHPSLA YCEDRVIEHY LKIKGLTRGQ AVVQYMKIVE
260 270 280 290 300
ALPTYGVHYY AVKDKQGLPW WLGISYKGIG QYDIQDKVKP RKLFQWKQLE
310 320 330 340 350
NLYFREKKFA VEVHDPRRIS VSRRTFGQSG LFVQTWYANS SLIKSIWVMA
360 370 380 390 400
ISQHQFYLDR KQSKAKIPSA RSLDEIAMDL TETGTQRASK LVTLETKSQF
410 420 430 440 450
IMASNGSLIS SGSQDSEVSE EQKREKILEL KKKEKLLQEK LLKKVEELKK
460 470 480 490 500
ICLREAELTG KMPKEYPLNI GEKPPQVRRR VGTAFKLDDN LLPSEEDPAL
510 520 530 540 550
QELESNFLIQ QKLVEAAKKL ANEPDLCKTV KKKRKQDYTD AMKKLQEIEN
560 570 580 590 600
AINEYRIRCG KKPSQKATVL PEDIIPSESS SLSDTTTYDD PSDAFTFPGQ
610 620 630 640 650
RSSSVPHSPR ILPPKSLGIE RIHFRKSSIN EQFVDTRQSR EMLSTHSSPY
660 670 680 690 700
KTLERRPQGG RSMPTTPVLT RNAYSSSHLE PESSSQHCRQ RSGSLESQSH
710 720 730 740 750
LLSEMDSDKP FFSLSKSQRS SSTEILDDGS SYTSQSSTEY YCVTPVTGPY
760 770 780 790 800
YTTQTLDTRT RGRRRSKKQN VSTSNSGSMP NLAQKDSLRN GVYSKSQEPP
810 820 830 840 850
SSSYYIAGYT PYAECDFYYS GGYVYENDTE GQYSVNPSYR SSAHYGYERQ
860 870 880 890 900
RDYSRSFHED EVDRVPHNPY ATLRLPRKAA AKSEHITKNI HKALVAEHLR
910 920 930 940 950
GWYQRASGQK DQGHSPQTSF DSDRGSQRCL GFAGLQVPCS PSSRASSYSS
960 970 980 990 1000
VSSTNASGNW RTQLTIGLSD YETPAHSSYT SCYGNVYNPL PSPSRQYTEI
1010 1020 1030
SQLDGTDGNQ LEDNLESSEQ RLFWHEDSKP GTLV
Length:1,034
Mass (Da):118,047
Last modified:May 3, 2011 - v4
Checksum:iA825A933DAF56263
GO
Isoform 2 (identifier: Q9Y2L6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: Missing.

Show »
Length:980
Mass (Da):111,634
Checksum:iD4D910C5C3EFE486
GO

Sequence cautioni

The sequence BAA76857.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti396 – 3961T → A in BAA76857 (PubMed:10231032).Curated
Sequence conflicti947 – 9471S → L in BAA76857 (PubMed:10231032).Curated
Sequence conflicti947 – 9471S → L in AAH28291 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5454Missing in isoform 2. 1 PublicationVSP_040895Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023230 mRNA. Translation: BAA76857.1. Different initiation.
AC112221 Genomic DNA. No translation available.
AC135851 Genomic DNA. No translation available.
DA339318 mRNA. No translation available.
BC028291 mRNA. Translation: AAH28291.1.
CCDSiCCDS46863.1. [Q9Y2L6-1]
RefSeqiNP_055938.1. NM_015123.2.
XP_006713126.1. XM_006713063.2. [Q9Y2L6-2]
XP_011531828.1. XM_011533526.1. [Q9Y2L6-2]
UniGeneiHs.371681.
Hs.709671.

Genome annotation databases

EnsembliENST00000398540; ENSP00000381549; ENSG00000114541. [Q9Y2L6-1]
GeneIDi23150.
KEGGihsa:23150.
UCSCiuc003dnv.3. human. [Q9Y2L6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023230 mRNA. Translation: BAA76857.1. Different initiation.
AC112221 Genomic DNA. No translation available.
AC135851 Genomic DNA. No translation available.
DA339318 mRNA. No translation available.
BC028291 mRNA. Translation: AAH28291.1.
CCDSiCCDS46863.1. [Q9Y2L6-1]
RefSeqiNP_055938.1. NM_015123.2.
XP_006713126.1. XM_006713063.2. [Q9Y2L6-2]
XP_011531828.1. XM_011533526.1. [Q9Y2L6-2]
UniGeneiHs.371681.
Hs.709671.

3D structure databases

ProteinModelPortaliQ9Y2L6.
SMRiQ9Y2L6. Positions 68-458.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116765. 1 interaction.
IntActiQ9Y2L6. 1 interaction.
MINTiMINT-2823146.
STRINGi9606.ENSP00000381549.

PTM databases

iPTMnetiQ9Y2L6.
PhosphoSiteiQ9Y2L6.

Polymorphism and mutation databases

BioMutaiFRMD4B.
DMDMi332278248.

Proteomic databases

EPDiQ9Y2L6.
MaxQBiQ9Y2L6.
PaxDbiQ9Y2L6.
PRIDEiQ9Y2L6.

Protocols and materials databases

DNASUi23150.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000398540; ENSP00000381549; ENSG00000114541. [Q9Y2L6-1]
GeneIDi23150.
KEGGihsa:23150.
UCSCiuc003dnv.3. human. [Q9Y2L6-1]

Organism-specific databases

CTDi23150.
GeneCardsiFRMD4B.
HGNCiHGNC:24886. FRMD4B.
HPAiHPA009705.
neXtProtiNX_Q9Y2L6.
PharmGKBiPA128394605.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3529. Eukaryota.
ENOG410XQFP. LUCA.
GeneTreeiENSGT00830000128251.
HOGENOMiHOG000294161.
HOVERGENiHBG062800.
InParanoidiQ9Y2L6.
OMAiNEYRIRC.
PhylomeDBiQ9Y2L6.
TreeFamiTF328984.

Miscellaneous databases

ChiTaRSiFRMD4B. human.
GenomeRNAii23150.
NextBioi44470.
PROiQ9Y2L6.

Gene expression databases

BgeeiQ9Y2L6.
CleanExiHS_FRMD4B.
ExpressionAtlasiQ9Y2L6. baseline and differential.
GenevisibleiQ9Y2L6. HS.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR021774. DUF3338.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR011993. PH_dom-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF11819. DUF3338. 1 hit.
PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
[Graphical view]
PRINTSiPR00935. BAND41.
SMARTiSM00295. B41. 1 hit.
SM01196. FERM_C. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-222 (ISOFORM 2).
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 780-1034 (ISOFORMS 1/2).
    Tissue: Testis.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-608 AND SER-915, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Platelet.

Entry informationi

Entry nameiFRM4B_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2L6
Secondary accession number(s): Q8TAI3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: May 3, 2011
Last modified: May 11, 2016
This is version 126 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.