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Protein

Trafficking protein particle complex subunit 8

Gene

TRAPPC8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Trafficking protein particle complex subunit 8
Alternative name(s):
Protein TRS85 homolog
Gene namesi
Name:TRAPPC8
Synonyms:KIAA1012
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:29169. TRAPPC8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165429149.

Polymorphism and mutation databases

BioMutaiTRAPPC8.
DMDMi296452850.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14351435Trafficking protein particle complex subunit 8PRO_0000065641Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei273 – 2731PhosphoserineCombined sources
Modified residuei279 – 2791PhosphoserineCombined sources
Modified residuei309 – 3091PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y2L5.
MaxQBiQ9Y2L5.
PaxDbiQ9Y2L5.
PeptideAtlasiQ9Y2L5.
PRIDEiQ9Y2L5.

PTM databases

iPTMnetiQ9Y2L5.
PhosphoSiteiQ9Y2L5.

Miscellaneous databases

PMAP-CutDBQ9Y2L5.

Expressioni

Gene expression databases

BgeeiENSG00000153339.
CleanExiHS_KIAA1012.
ExpressionAtlasiQ9Y2L5. baseline and differential.
GenevisibleiQ9Y2L5. HS.

Organism-specific databases

HPAiHPA041107.

Interactioni

Subunit structurei

Component of the multisubunit TRAPP (transport protein particle) complex, which includes TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TRAPPC13A5PLN92EBI-2820056,EBI-2857298
TRAPPC3O436172EBI-2820056,EBI-743566

Protein-protein interaction databases

BioGridi116545. 25 interactions.
DIPiDIP-48280N.
IntActiQ9Y2L5. 6 interactions.
MINTiMINT-4713485.
STRINGi9606.ENSP00000283351.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2L5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TRS85 family.Curated

Phylogenomic databases

eggNOGiKOG1938. Eukaryota.
ENOG410XPCJ. LUCA.
GeneTreeiENSGT00390000000568.
HOGENOMiHOG000046881.
HOVERGENiHBG036226.
InParanoidiQ9Y2L5.
KOiK20305.
OMAiNTGIIHG.
OrthoDBiEOG091G062Q.
PhylomeDBiQ9Y2L5.
TreeFamiTF106128.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR011990. TPR-like_helical_dom.
IPR024420. TRAPP_III_complex_Trs85.
[Graphical view]
PANTHERiPTHR12975. PTHR12975. 3 hits.
PfamiPF12739. TRAPPC-Trs85. 1 hit.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y2L5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQCVQSVQE LIPDSFVPCV AALCSDEAER LTRLNHLSFA ELLKPFSRLT
60 70 80 90 100
SEVHMRDPNN QLHVIKNLKI AVSNIVTQPP QPGAIRKLLN DVVSGSQPAE
110 120 130 140 150
GLVANVITAG DYDLNISATT PWFESYRETF LQSMPALDHE FLNHYLACML
160 170 180 190 200
VASSSEAEPV EQFSKLSQEQ HRIQHNSDYS YPKWFIPNTL KYYVLLHDVS
210 220 230 240 250
AGDEQRAESI YEEMKQKYGT QGCYLLKINS RTSNRASDEQ IPDPWSQYLQ
260 270 280 290 300
KNSIQNQESY EDGPCTITSN KNSDNNLLSL DGLDNEVKDG LPNNFRAHPL
310 320 330 340 350
QLEQSSDPSN SIDGPDHLRS ASSLHETKKG NTGIIHGACL TLTDHDRIRQ
360 370 380 390 400
FIQEFTFRGL LPHIEKTIRQ LNDQLISRKG LSRSLFSATK KWFSGSKVPE
410 420 430 440 450
KSINDLKNTS GLLYPPEAPE LQIRKMADLC FLVQHYDLAY SCYHTAKKDF
460 470 480 490 500
LNDQAMLYAA GALEMAAVSA FLQPGAPRPY PAHYMDTAIQ TYRDICKNMV
510 520 530 540 550
LAERCVLLSA ELLKSQSKYS EAAALLIRLT SEDSDLRSAL LLEQAAHCFI
560 570 580 590 600
NMKSPMVRKY AFHMILAGHR FSKAGQKKHA LRCYCQAMQV YKGKGWSLAE
610 620 630 640 650
DHINFTIGRQ SYTLRQLDNA VSAFRHILIN ESKQSAAQQG AFLREYLYVY
660 670 680 690 700
KNVSQLSPDG PLPQLPLPYI NSSATRVFFG HDRRPADGEK QAATHVSLDQ
710 720 730 740 750
EYDSESSQQW RELEEQVVSV VNKGVIPSNF HPTQYCLNSY SDNSRFPLAV
760 770 780 790 800
VEEPITVEVA FRNPLKVLLL LTDLSLLWKF HPKDFSGKDN EEVKQLVTSE
810 820 830 840 850
PEMIGAEVIS EFLINGEESK VARLKLFPHH IGELHILGVV YNLGTIQGSM
860 870 880 890 900
TVDGIGALPG CHTGKYSLSM SVRGKQDLEI QGPRLNNTKE EKTSVKYGPD
910 920 930 940 950
RRLDPIITEE MPLLEVFFIH FPTGLLCGEI RKAYVEFVNV SKCPLTGLKV
960 970 980 990 1000
VSKRPEFFTF GGNTAVLTPL SPSASENCSA YKTVVTDATS VCTALISSAS
1010 1020 1030 1040 1050
SVDFGIGTGS QPEVIPVPLP DTVLLPGASV QLPMWLRGPD EEGVHEINFL
1060 1070 1080 1090 1100
FYYESVKKQP KIRHRILRHT AIICTSRSLN VRATVCRSNS LENEEGRGGN
1110 1120 1130 1140 1150
MLVFVDVENT NTSEAGVKEF HIVQVSSSSK HWKLQKSVNL SENKDTKLAS
1160 1170 1180 1190 1200
REKGKFCFKA IRCEKEEAAT QSSEKYTFAD IIFGNEQIIS SASPCADFFY
1210 1220 1230 1240 1250
RSLSSELKKP QAHLPVHTEK QSTEDAVRLI QKCSEVDLNI VILWKAYVVE
1260 1270 1280 1290 1300
DSKQLILEGQ HHVILRTIGK EAFSYPQKQE PPEMELLKFF RPENITVSSR
1310 1320 1330 1340 1350
PSVEQLSSLI KTSLHYPESF NHPFHQKSLC LVPVTLLLSN CSKADVDVIV
1360 1370 1380 1390 1400
DLRHKTTSPE ALEIHGSFTW LGQTQYKLQL KSQEIHSLQL KACFVHTGVY
1410 1420 1430
NLGTPRVFAK LSDQVTVFET SQQNSMPALI IISNV
Length:1,435
Mass (Da):160,997
Last modified:May 18, 2010 - v2
Checksum:iA6D60A7C9E65F46D
GO
Isoform 2 (identifier: Q9Y2L5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     916-926: VFFIHFPTGLL → TLALAQEVNQR
     927-1002: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.
Show »
Length:1,359
Mass (Da):153,030
Checksum:i64D376D99DE70D11
GO

Sequence cautioni

The sequence AAI27110 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI27111 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA76856 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAG50957 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti251 – 2511K → E in CAB66683 (PubMed:11230166).Curated
Sequence conflicti631 – 6311E → G in BAG50957 (PubMed:14702039).Curated
Sequence conflicti1060 – 10601P → T in BAG50957 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti74 – 741N → S.
Corresponds to variant rs34292533 [ dbSNP | Ensembl ].
VAR_057814
Natural varianti137 – 1371L → S.2 Publications
Corresponds to variant rs6506948 [ dbSNP | Ensembl ].
VAR_060250
Natural varianti517 – 5171S → G.
Corresponds to variant rs17857486 [ dbSNP | Ensembl ].
VAR_060251
Natural varianti537 – 5371R → Q in a breast cancer sample; somatic mutation. 1 Publication
Corresponds to variant rs754569032 [ dbSNP | Ensembl ].
VAR_036270
Natural varianti708 – 7081Q → E.
Corresponds to variant rs16962530 [ dbSNP | Ensembl ].
VAR_057815
Natural varianti954 – 9541R → H.
Corresponds to variant rs2170562 [ dbSNP | Ensembl ].
VAR_060252
Natural varianti1146 – 11461T → A.1 Publication
Corresponds to variant rs3737374 [ dbSNP | Ensembl ].
VAR_060253
Natural varianti1189 – 11891I → V.
Corresponds to variant rs36034613 [ dbSNP | Ensembl ].
VAR_057816
Natural varianti1298 – 12981S → P.
Corresponds to variant rs633500 [ dbSNP | Ensembl ].
VAR_060254

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei916 – 92611VFFIHFPTGLL → TLALAQEVNQR in isoform 2. 1 PublicationVSP_014454Add
BLAST
Alternative sequencei927 – 100276Missing in isoform 2. 1 PublicationVSP_004000Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023229 mRNA. Translation: BAA76856.2. Different initiation.
AL136749 mRNA. Translation: CAB66683.2.
AC009831 Genomic DNA. No translation available.
AC022960 Genomic DNA. No translation available.
BC127109 mRNA. Translation: AAI27110.1. Different initiation.
BC127110 mRNA. Translation: AAI27111.1. Different initiation.
AK001662 mRNA. Translation: BAG50957.1. Different initiation.
CCDSiCCDS11901.1. [Q9Y2L5-1]
RefSeqiNP_055754.2. NM_014939.3.
UniGeneiHs.202001.

Genome annotation databases

EnsembliENST00000283351; ENSP00000283351; ENSG00000153339. [Q9Y2L5-1]
GeneIDi22878.
KEGGihsa:22878.
UCSCiuc002kxc.5. human. [Q9Y2L5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023229 mRNA. Translation: BAA76856.2. Different initiation.
AL136749 mRNA. Translation: CAB66683.2.
AC009831 Genomic DNA. No translation available.
AC022960 Genomic DNA. No translation available.
BC127109 mRNA. Translation: AAI27110.1. Different initiation.
BC127110 mRNA. Translation: AAI27111.1. Different initiation.
AK001662 mRNA. Translation: BAG50957.1. Different initiation.
CCDSiCCDS11901.1. [Q9Y2L5-1]
RefSeqiNP_055754.2. NM_014939.3.
UniGeneiHs.202001.

3D structure databases

ProteinModelPortaliQ9Y2L5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116545. 25 interactions.
DIPiDIP-48280N.
IntActiQ9Y2L5. 6 interactions.
MINTiMINT-4713485.
STRINGi9606.ENSP00000283351.

PTM databases

iPTMnetiQ9Y2L5.
PhosphoSiteiQ9Y2L5.

Polymorphism and mutation databases

BioMutaiTRAPPC8.
DMDMi296452850.

Proteomic databases

EPDiQ9Y2L5.
MaxQBiQ9Y2L5.
PaxDbiQ9Y2L5.
PeptideAtlasiQ9Y2L5.
PRIDEiQ9Y2L5.

Protocols and materials databases

DNASUi22878.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000283351; ENSP00000283351; ENSG00000153339. [Q9Y2L5-1]
GeneIDi22878.
KEGGihsa:22878.
UCSCiuc002kxc.5. human. [Q9Y2L5-1]

Organism-specific databases

CTDi22878.
GeneCardsiTRAPPC8.
H-InvDBHIX0014382.
HIX0039822.
HGNCiHGNC:29169. TRAPPC8.
HPAiHPA041107.
MIMi614136. gene.
neXtProtiNX_Q9Y2L5.
PharmGKBiPA165429149.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1938. Eukaryota.
ENOG410XPCJ. LUCA.
GeneTreeiENSGT00390000000568.
HOGENOMiHOG000046881.
HOVERGENiHBG036226.
InParanoidiQ9Y2L5.
KOiK20305.
OMAiNTGIIHG.
OrthoDBiEOG091G062Q.
PhylomeDBiQ9Y2L5.
TreeFamiTF106128.

Miscellaneous databases

ChiTaRSiTRAPPC8. human.
GeneWikiiKIAA1012.
GenomeRNAii22878.
PMAP-CutDBQ9Y2L5.
PROiQ9Y2L5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000153339.
CleanExiHS_KIAA1012.
ExpressionAtlasiQ9Y2L5. baseline and differential.
GenevisibleiQ9Y2L5. HS.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR011990. TPR-like_helical_dom.
IPR024420. TRAPP_III_complex_Trs85.
[Graphical view]
PANTHERiPTHR12975. PTHR12975. 3 hits.
PfamiPF12739. TRAPPC-Trs85. 1 hit.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTPPC8_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2L5
Secondary accession number(s): A0JP15, B3KME5, Q9H0L2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: May 18, 2010
Last modified: September 7, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.