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Protein

Syntaxin-binding protein 5-like

Gene

STXBP5L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in vesicle trafficking and exocytosis.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Exocytosis, Protein transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000145087-MONOMER.
SignaLinkiQ9Y2K9.

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-binding protein 5-like
Alternative name(s):
Lethal(2) giant larvae protein homolog 4
Tomosyn-2
Gene namesi
Name:STXBP5L
Synonyms:KIAA1006, LLGL4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:30757. STXBP5L.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9515.
OpenTargetsiENSG00000145087.
PharmGKBiPA134976391.

Polymorphism and mutation databases

BioMutaiSTXBP5L.
DMDMi82582271.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000512471 – 1186Syntaxin-binding protein 5-likeAdd BLAST1186

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei568PhosphothreonineBy similarity1
Modified residuei574PhosphoserineBy similarity1
Modified residuei589PhosphoserineBy similarity1
Modified residuei596PhosphothreonineBy similarity1
Modified residuei599PhosphoserineBy similarity1
Modified residuei709Omega-N-methylarginineBy similarity1
Modified residuei793PhosphoserineBy similarity1
Modified residuei823PhosphoserineBy similarity1
Modified residuei1093PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ9Y2K9.
PaxDbiQ9Y2K9.
PeptideAtlasiQ9Y2K9.
PRIDEiQ9Y2K9.

PTM databases

iPTMnetiQ9Y2K9.
PhosphoSitePlusiQ9Y2K9.

Expressioni

Tissue specificityi

Detected in kidney, hippocampus and lung carcinoma.1 Publication

Gene expression databases

BgeeiENSG00000145087.
CleanExiHS_STXBP5L.
ExpressionAtlasiQ9Y2K9. baseline and differential.
GenevisibleiQ9Y2K9. HS.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114892. 246 interactors.
IntActiQ9Y2K9. 1 interactor.
STRINGi9606.ENSP00000273666.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2K9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati74 – 107WD 1Add BLAST34
Repeati114 – 153WD 2Add BLAST40
Repeati158 – 194WD 3Add BLAST37
Repeati213 – 247WD 4Add BLAST35
Repeati253 – 285WD 5Add BLAST33
Repeati307 – 349WD 6Add BLAST43
Repeati357 – 391WD 7Add BLAST35
Repeati413 – 490WD 8Add BLAST78
Repeati518 – 629WD 9Add BLAST112
Repeati643 – 705WD 10Add BLAST63
Repeati832 – 889WD 11Add BLAST58
Repeati898 – 969WD 12Add BLAST72
Repeati974 – 1018WD 13Add BLAST45
Repeati1032 – 1055WD 14Add BLAST24
Domaini1121 – 1181v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST61

Sequence similaritiesi

Belongs to the WD repeat L(2)GL family.Curated
Contains 1 v-SNARE coiled-coil homology domain.PROSITE-ProRule annotation
Contains 14 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410INFH. Eukaryota.
ENOG410XTER. LUCA.
GeneTreeiENSGT00390000000018.
HOGENOMiHOG000110929.
HOVERGENiHBG083064.
InParanoidiQ9Y2K9.
KOiK08518.
OMAiMCDNLQE.
OrthoDBiEOG091G0LY3.
PhylomeDBiQ9Y2K9.
TreeFamiTF314585.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR000664. Lethal2_giant.
IPR013905. Lgl_C_dom.
IPR013577. LLGL2.
IPR001388. Synaptobrevin.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08596. Lgl_C. 1 hit.
PF08366. LLGL. 1 hit.
PF00400. WD40. 1 hit.
[Graphical view]
PRINTSiPR00962. LETHAL2GIANT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 6 hits.
PROSITEiPS50892. V_SNARE. 1 hit.
PS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y2K9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKKFNFRKVL DGLTASSPGS GSSSGSNSGG GAGSGSVHPA GTAGVLREEI
60 70 80 90 100
QETLTSEYFQ ICKTVRHGFP HQPTALAFDP VQKILAIGTR TGAIRILGRP
110 120 130 140 150
GVDCYCQHES GAAVLQLQFL INEGALVSAS SDDTLHLWNL RQKRPAILHS
160 170 180 190 200
LKFNRERITY CHLPFQSKWL YVGTERGNTH IVNIESFILS GYVIMWNKAI
210 220 230 240 250
ELSTKTHPGP VVHLSDSPRD EGKLLIGYEN GTVVFWDLKS KRAELRVYYD
260 270 280 290 300
EAIHSIDWHH EGKQFMCSHS DGSLTLWNLK SPSRPFQTTI PHGKSQREGR
310 320 330 340 350
KSESCKPILK VEYKTCKNSE PFIIFSGGLS YDKACRRPSL TIMHGKAITV
360 370 380 390 400
LEMDHPIVEF LTLCETPYPN EFQEPYAVVV LLEKDLIVVD LTQSNFPIFE
410 420 430 440 450
NPYPMDIHES PVTCTAYFAD CPPDLILVLY SIGVKHKKQG YSNKEWPISG
460 470 480 490 500
GAWNLGAQTY PEIIITGHAD GSIKFWDASA ITLQMLYKLK TSKVFEKQKV
510 520 530 540 550
GEGKQTCEIV EEDPFAIQMI YWCPESRIFC VSGVSAYVII YKFSRHEITT
560 570 580 590 600
EIVSLEVRLQ YDVEDIITPE PETSPPFPDL SAQLPSSRSL SGSTNTVASE
610 620 630 640 650
GVTKDSIPCL NVKTRPVRMP PGYQAELVIQ LVWVDGEPPQ QITSLAVSSA
660 670 680 690 700
YGIVAFGNCN GLAVVDFIQK TVLLSMGTID LYRSSDLYQR QPRSPRKNKQ
710 720 730 740 750
FIADNFCMRG LSNFYPDLTK RIRTSYQSLT ELNDSPVPLE LERCKSPTSD
760 770 780 790 800
HVNGHCTSPT SQSCSSGKRL SSADVSKVNR WGPGRPPFRK AQSAACMEIS
810 820 830 840 850
LPVTTEENRE NSYNRSRSSS ISSIDKDSKE AITALYFMDS FARKNDSTIS
860 870 880 890 900
PCLFVGTSLG MVLIISLNLP LADEQRFTEP VMVLPSGTFL SLKGAVLTFS
910 920 930 940 950
CMDRMGGLMQ PPYEVWRDPN NIDENEKSWR RKVVMNSSSA SQEIGDHQYT
960 970 980 990 1000
IICSEKQAKV FSLPSQTCLY VHNITETSFI LQANVVVMCS SACLACFCAN
1010 1020 1030 1040 1050
GHIMIMSLPS LRPMLDVNYL PLTDMRIART FCFTNEGQAL YLVSPTEIQR
1060 1070 1080 1090 1100
LTYSQEMCDN LQDMLGDLFT PIETPEAQNR GFLKGLFGGS GQTFDREELF
1110 1120 1130 1140 1150
GEASAGKASR SLAQHIPGPG SIEGMKGAAG GVMGELTRAR IALDERGQRL
1160 1170 1180
GELEEKTAGM MTSAEAFSKH AHELMLKYKD KKWYQF
Length:1,186
Mass (Da):131,887
Last modified:November 22, 2005 - v2
Checksum:i8CBDB5FAB4B777DA
GO
Isoform 2 (identifier: Q9Y2K9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     64-74: TVRHGFPHQPT → FGMVFLISPQH
     75-1186: Missing.

Note: No experimental confirmation available.
Show »
Length:74
Mass (Da):7,638
Checksum:iA359097C23BD7601
GO

Sequence cautioni

The sequence BAA76850 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti819S → Y in AAH37531 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050076568T → S.Corresponds to variant rs17249244dbSNPEnsembl.1
Natural variantiVAR_050077855V → I.Corresponds to variant rs17740066dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01629364 – 74TVRHGFPHQPT → FGMVFLISPQH in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_01629475 – 1186Missing in isoform 2. 1 PublicationAdd BLAST1112

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023223 mRNA. Translation: BAA76850.1. Different initiation.
BC022029 mRNA. Translation: AAH22029.1.
BC037531 mRNA. Translation: AAH37531.1.
CCDSiCCDS43137.1. [Q9Y2K9-1]
RefSeqiNP_055795.1. NM_014980.2. [Q9Y2K9-1]
XP_006713888.1. XM_006713825.3. [Q9Y2K9-1]
XP_016863019.1. XM_017007530.1. [Q9Y2K9-1]
UniGeneiHs.477315.

Genome annotation databases

EnsembliENST00000273666; ENSP00000273666; ENSG00000145087. [Q9Y2K9-1]
ENST00000461772; ENSP00000420642; ENSG00000145087. [Q9Y2K9-2]
GeneIDi9515.
KEGGihsa:9515.
UCSCiuc003eec.5. human. [Q9Y2K9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023223 mRNA. Translation: BAA76850.1. Different initiation.
BC022029 mRNA. Translation: AAH22029.1.
BC037531 mRNA. Translation: AAH37531.1.
CCDSiCCDS43137.1. [Q9Y2K9-1]
RefSeqiNP_055795.1. NM_014980.2. [Q9Y2K9-1]
XP_006713888.1. XM_006713825.3. [Q9Y2K9-1]
XP_016863019.1. XM_017007530.1. [Q9Y2K9-1]
UniGeneiHs.477315.

3D structure databases

ProteinModelPortaliQ9Y2K9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114892. 246 interactors.
IntActiQ9Y2K9. 1 interactor.
STRINGi9606.ENSP00000273666.

PTM databases

iPTMnetiQ9Y2K9.
PhosphoSitePlusiQ9Y2K9.

Polymorphism and mutation databases

BioMutaiSTXBP5L.
DMDMi82582271.

Proteomic databases

EPDiQ9Y2K9.
PaxDbiQ9Y2K9.
PeptideAtlasiQ9Y2K9.
PRIDEiQ9Y2K9.

Protocols and materials databases

DNASUi9515.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000273666; ENSP00000273666; ENSG00000145087. [Q9Y2K9-1]
ENST00000461772; ENSP00000420642; ENSG00000145087. [Q9Y2K9-2]
GeneIDi9515.
KEGGihsa:9515.
UCSCiuc003eec.5. human. [Q9Y2K9-1]

Organism-specific databases

CTDi9515.
DisGeNETi9515.
GeneCardsiSTXBP5L.
HGNCiHGNC:30757. STXBP5L.
MIMi609381. gene.
neXtProtiNX_Q9Y2K9.
OpenTargetsiENSG00000145087.
PharmGKBiPA134976391.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410INFH. Eukaryota.
ENOG410XTER. LUCA.
GeneTreeiENSGT00390000000018.
HOGENOMiHOG000110929.
HOVERGENiHBG083064.
InParanoidiQ9Y2K9.
KOiK08518.
OMAiMCDNLQE.
OrthoDBiEOG091G0LY3.
PhylomeDBiQ9Y2K9.
TreeFamiTF314585.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000145087-MONOMER.
SignaLinkiQ9Y2K9.

Miscellaneous databases

ChiTaRSiSTXBP5L. human.
GenomeRNAii9515.
PROiQ9Y2K9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000145087.
CleanExiHS_STXBP5L.
ExpressionAtlasiQ9Y2K9. baseline and differential.
GenevisibleiQ9Y2K9. HS.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR000664. Lethal2_giant.
IPR013905. Lgl_C_dom.
IPR013577. LLGL2.
IPR001388. Synaptobrevin.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08596. Lgl_C. 1 hit.
PF08366. LLGL. 1 hit.
PF00400. WD40. 1 hit.
[Graphical view]
PRINTSiPR00962. LETHAL2GIANT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 6 hits.
PROSITEiPS50892. V_SNARE. 1 hit.
PS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTB5L_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2K9
Secondary accession number(s): Q4G1B4, Q6PIC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: November 2, 2016
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.