Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Syntaxin-binding protein 5-like

Gene

STXBP5L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in vesicle trafficking and exocytosis.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Exocytosis, Protein transport, Transport

Enzyme and pathway databases

SignaLinkiQ9Y2K9.

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-binding protein 5-like
Alternative name(s):
Lethal(2) giant larvae protein homolog 4
Tomosyn-2
Gene namesi
Name:STXBP5L
Synonyms:KIAA1006, LLGL4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:30757. STXBP5L.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134976391.

Polymorphism and mutation databases

BioMutaiSTXBP5L.
DMDMi82582271.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11861186Syntaxin-binding protein 5-likePRO_0000051247Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources
Modified residuei568 – 5681PhosphothreonineBy similarity
Modified residuei574 – 5741PhosphoserineBy similarity
Modified residuei589 – 5891PhosphoserineBy similarity
Modified residuei596 – 5961PhosphothreonineBy similarity
Modified residuei599 – 5991PhosphoserineBy similarity
Modified residuei793 – 7931PhosphoserineBy similarity
Modified residuei823 – 8231PhosphoserineBy similarity
Modified residuei1093 – 10931PhosphothreonineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9Y2K9.
MaxQBiQ9Y2K9.
PaxDbiQ9Y2K9.
PeptideAtlasiQ9Y2K9.
PRIDEiQ9Y2K9.

PTM databases

iPTMnetiQ9Y2K9.
PhosphoSiteiQ9Y2K9.

Expressioni

Tissue specificityi

Detected in kidney, hippocampus and lung carcinoma.1 Publication

Gene expression databases

BgeeiQ9Y2K9.
CleanExiHS_STXBP5L.
ExpressionAtlasiQ9Y2K9. baseline and differential.
GenevisibleiQ9Y2K9. HS.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114892. 246 interactions.
IntActiQ9Y2K9. 1 interaction.
STRINGi9606.ENSP00000273666.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2K9.
SMRiQ9Y2K9. Positions 1122-1178.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati74 – 10734WD 1Add
BLAST
Repeati114 – 15340WD 2Add
BLAST
Repeati158 – 19437WD 3Add
BLAST
Repeati213 – 24735WD 4Add
BLAST
Repeati253 – 28533WD 5Add
BLAST
Repeati307 – 34943WD 6Add
BLAST
Repeati357 – 39135WD 7Add
BLAST
Repeati413 – 49078WD 8Add
BLAST
Repeati518 – 629112WD 9Add
BLAST
Repeati643 – 70563WD 10Add
BLAST
Repeati832 – 88958WD 11Add
BLAST
Repeati898 – 96972WD 12Add
BLAST
Repeati974 – 101845WD 13Add
BLAST
Repeati1032 – 105524WD 14Add
BLAST
Domaini1121 – 118161v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the WD repeat L(2)GL family.Curated
Contains 1 v-SNARE coiled-coil homology domain.PROSITE-ProRule annotation
Contains 14 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410INFH. Eukaryota.
ENOG410XTER. LUCA.
GeneTreeiENSGT00390000000018.
HOGENOMiHOG000110929.
HOVERGENiHBG083064.
InParanoidiQ9Y2K9.
KOiK08518.
OMAiMCDNLQE.
OrthoDBiEOG7DVD96.
PhylomeDBiQ9Y2K9.
TreeFamiTF314585.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR000664. Lethal2_giant.
IPR013905. Lgl_C_dom.
IPR013577. LLGL2.
IPR001388. Synaptobrevin.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08596. Lgl_C. 1 hit.
PF08366. LLGL. 1 hit.
PF00400. WD40. 1 hit.
[Graphical view]
PRINTSiPR00962. LETHAL2GIANT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 6 hits.
PROSITEiPS50892. V_SNARE. 1 hit.
PS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y2K9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKKFNFRKVL DGLTASSPGS GSSSGSNSGG GAGSGSVHPA GTAGVLREEI
60 70 80 90 100
QETLTSEYFQ ICKTVRHGFP HQPTALAFDP VQKILAIGTR TGAIRILGRP
110 120 130 140 150
GVDCYCQHES GAAVLQLQFL INEGALVSAS SDDTLHLWNL RQKRPAILHS
160 170 180 190 200
LKFNRERITY CHLPFQSKWL YVGTERGNTH IVNIESFILS GYVIMWNKAI
210 220 230 240 250
ELSTKTHPGP VVHLSDSPRD EGKLLIGYEN GTVVFWDLKS KRAELRVYYD
260 270 280 290 300
EAIHSIDWHH EGKQFMCSHS DGSLTLWNLK SPSRPFQTTI PHGKSQREGR
310 320 330 340 350
KSESCKPILK VEYKTCKNSE PFIIFSGGLS YDKACRRPSL TIMHGKAITV
360 370 380 390 400
LEMDHPIVEF LTLCETPYPN EFQEPYAVVV LLEKDLIVVD LTQSNFPIFE
410 420 430 440 450
NPYPMDIHES PVTCTAYFAD CPPDLILVLY SIGVKHKKQG YSNKEWPISG
460 470 480 490 500
GAWNLGAQTY PEIIITGHAD GSIKFWDASA ITLQMLYKLK TSKVFEKQKV
510 520 530 540 550
GEGKQTCEIV EEDPFAIQMI YWCPESRIFC VSGVSAYVII YKFSRHEITT
560 570 580 590 600
EIVSLEVRLQ YDVEDIITPE PETSPPFPDL SAQLPSSRSL SGSTNTVASE
610 620 630 640 650
GVTKDSIPCL NVKTRPVRMP PGYQAELVIQ LVWVDGEPPQ QITSLAVSSA
660 670 680 690 700
YGIVAFGNCN GLAVVDFIQK TVLLSMGTID LYRSSDLYQR QPRSPRKNKQ
710 720 730 740 750
FIADNFCMRG LSNFYPDLTK RIRTSYQSLT ELNDSPVPLE LERCKSPTSD
760 770 780 790 800
HVNGHCTSPT SQSCSSGKRL SSADVSKVNR WGPGRPPFRK AQSAACMEIS
810 820 830 840 850
LPVTTEENRE NSYNRSRSSS ISSIDKDSKE AITALYFMDS FARKNDSTIS
860 870 880 890 900
PCLFVGTSLG MVLIISLNLP LADEQRFTEP VMVLPSGTFL SLKGAVLTFS
910 920 930 940 950
CMDRMGGLMQ PPYEVWRDPN NIDENEKSWR RKVVMNSSSA SQEIGDHQYT
960 970 980 990 1000
IICSEKQAKV FSLPSQTCLY VHNITETSFI LQANVVVMCS SACLACFCAN
1010 1020 1030 1040 1050
GHIMIMSLPS LRPMLDVNYL PLTDMRIART FCFTNEGQAL YLVSPTEIQR
1060 1070 1080 1090 1100
LTYSQEMCDN LQDMLGDLFT PIETPEAQNR GFLKGLFGGS GQTFDREELF
1110 1120 1130 1140 1150
GEASAGKASR SLAQHIPGPG SIEGMKGAAG GVMGELTRAR IALDERGQRL
1160 1170 1180
GELEEKTAGM MTSAEAFSKH AHELMLKYKD KKWYQF
Length:1,186
Mass (Da):131,887
Last modified:November 22, 2005 - v2
Checksum:i8CBDB5FAB4B777DA
GO
Isoform 2 (identifier: Q9Y2K9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     64-74: TVRHGFPHQPT → FGMVFLISPQH
     75-1186: Missing.

Note: No experimental confirmation available.
Show »
Length:74
Mass (Da):7,638
Checksum:iA359097C23BD7601
GO

Sequence cautioni

The sequence BAA76850.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti819 – 8191S → Y in AAH37531 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti568 – 5681T → S.
Corresponds to variant rs17249244 [ dbSNP | Ensembl ].
VAR_050076
Natural varianti855 – 8551V → I.
Corresponds to variant rs17740066 [ dbSNP | Ensembl ].
VAR_050077

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei64 – 7411TVRHGFPHQPT → FGMVFLISPQH in isoform 2. 1 PublicationVSP_016293Add
BLAST
Alternative sequencei75 – 11861112Missing in isoform 2. 1 PublicationVSP_016294Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023223 mRNA. Translation: BAA76850.1. Different initiation.
BC022029 mRNA. Translation: AAH22029.1.
BC037531 mRNA. Translation: AAH37531.1.
CCDSiCCDS43137.1. [Q9Y2K9-1]
RefSeqiNP_055795.1. NM_014980.2. [Q9Y2K9-1]
XP_006713888.1. XM_006713825.2. [Q9Y2K9-1]
UniGeneiHs.477315.

Genome annotation databases

EnsembliENST00000273666; ENSP00000273666; ENSG00000145087. [Q9Y2K9-1]
ENST00000461772; ENSP00000420642; ENSG00000145087. [Q9Y2K9-2]
GeneIDi9515.
KEGGihsa:9515.
UCSCiuc003eec.5. human. [Q9Y2K9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023223 mRNA. Translation: BAA76850.1. Different initiation.
BC022029 mRNA. Translation: AAH22029.1.
BC037531 mRNA. Translation: AAH37531.1.
CCDSiCCDS43137.1. [Q9Y2K9-1]
RefSeqiNP_055795.1. NM_014980.2. [Q9Y2K9-1]
XP_006713888.1. XM_006713825.2. [Q9Y2K9-1]
UniGeneiHs.477315.

3D structure databases

ProteinModelPortaliQ9Y2K9.
SMRiQ9Y2K9. Positions 1122-1178.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114892. 246 interactions.
IntActiQ9Y2K9. 1 interaction.
STRINGi9606.ENSP00000273666.

PTM databases

iPTMnetiQ9Y2K9.
PhosphoSiteiQ9Y2K9.

Polymorphism and mutation databases

BioMutaiSTXBP5L.
DMDMi82582271.

Proteomic databases

EPDiQ9Y2K9.
MaxQBiQ9Y2K9.
PaxDbiQ9Y2K9.
PeptideAtlasiQ9Y2K9.
PRIDEiQ9Y2K9.

Protocols and materials databases

DNASUi9515.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000273666; ENSP00000273666; ENSG00000145087. [Q9Y2K9-1]
ENST00000461772; ENSP00000420642; ENSG00000145087. [Q9Y2K9-2]
GeneIDi9515.
KEGGihsa:9515.
UCSCiuc003eec.5. human. [Q9Y2K9-1]

Organism-specific databases

CTDi9515.
GeneCardsiSTXBP5L.
HGNCiHGNC:30757. STXBP5L.
MIMi609381. gene.
neXtProtiNX_Q9Y2K9.
PharmGKBiPA134976391.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410INFH. Eukaryota.
ENOG410XTER. LUCA.
GeneTreeiENSGT00390000000018.
HOGENOMiHOG000110929.
HOVERGENiHBG083064.
InParanoidiQ9Y2K9.
KOiK08518.
OMAiMCDNLQE.
OrthoDBiEOG7DVD96.
PhylomeDBiQ9Y2K9.
TreeFamiTF314585.

Enzyme and pathway databases

SignaLinkiQ9Y2K9.

Miscellaneous databases

ChiTaRSiSTXBP5L. human.
GenomeRNAii9515.
PROiQ9Y2K9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y2K9.
CleanExiHS_STXBP5L.
ExpressionAtlasiQ9Y2K9. baseline and differential.
GenevisibleiQ9Y2K9. HS.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR000664. Lethal2_giant.
IPR013905. Lgl_C_dom.
IPR013577. LLGL2.
IPR001388. Synaptobrevin.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08596. Lgl_C. 1 hit.
PF08366. LLGL. 1 hit.
PF00400. WD40. 1 hit.
[Graphical view]
PRINTSiPR00962. LETHAL2GIANT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 6 hits.
PROSITEiPS50892. V_SNARE. 1 hit.
PS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 434-1186 (ISOFORM 1).
    Tissue: Brain.
  3. "Identification and characterization of human LLGL4 gene and mouse Llgl4 gene in silico."
    Katoh M., Katoh M.
    Int. J. Oncol. 24:737-742(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  4. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSTB5L_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2K9
Secondary accession number(s): Q4G1B4, Q6PIC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: July 6, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.