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Q9Y2K3

- MYH15_HUMAN

UniProt

Q9Y2K3 - MYH15_HUMAN

Protein

Myosin-15

Gene

MYH15

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 5 (18 May 2010)
      Previous versions | rss
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    Functioni

    Muscle contraction.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi196 – 2038ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. motor activity Source: InterPro

    Keywords - Molecular functioni

    Motor protein, Muscle protein, Myosin

    Keywords - Ligandi

    Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_147867. Translocation of GLUT4 to the plasma membrane.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myosin-15
    Alternative name(s):
    Myosin heavy chain 15
    Gene namesi
    Name:MYH15
    Synonyms:KIAA1000
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:31073. MYH15.

    Subcellular locationi

    Cytoplasmmyofibril
    Note: Thick filaments of the myofibrils.

    GO - Cellular componenti

    1. myofibril Source: UniProtKB-SubCell
    2. myosin filament Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cytoplasm, Thick filament

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134958635.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 19461946Myosin-15PRO_0000274233Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei147 – 1471N6,N6,N6-trimethyllysineSequence Analysis

    Keywords - PTMi

    Methylation

    Proteomic databases

    PaxDbiQ9Y2K3.
    PRIDEiQ9Y2K3.

    PTM databases

    PhosphoSiteiQ9Y2K3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Y2K3.
    BgeeiQ9Y2K3.
    CleanExiHS_MYH15.
    GenevestigatoriQ9Y2K3.

    Organism-specific databases

    HPAiHPA034871.

    Interactioni

    Subunit structurei

    Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).By similarity

    Protein-protein interaction databases

    BioGridi116637. 1 interaction.
    STRINGi9606.ENSP00000273353.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y2K3.
    SMRiQ9Y2K3. Positions 22-973.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini103 – 790688Myosin motorAdd
    BLAST
    Domaini793 – 82230IQAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni667 – 68923Actin-bindingBy similarityAdd
    BLAST
    Regioni769 – 78315Actin-bindingBy similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili853 – 19461094Sequence AnalysisAdd
    BLAST

    Domaini

    The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.By similarity

    Sequence similaritiesi

    Contains 1 IQ domain.Curated
    Contains 1 myosin motor domain.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG5022.
    HOGENOMiHOG000173959.
    HOVERGENiHBG004704.
    InParanoidiQ9Y2K3.
    KOiK10352.
    OMAiIIQYFAT.
    OrthoDBiEOG7RBZ7G.
    PhylomeDBiQ9Y2K3.
    TreeFamiTF314375.

    Family and domain databases

    Gene3Di4.10.270.10. 1 hit.
    InterProiIPR027401. Myosin-like_IQ_dom.
    IPR001609. Myosin_head_motor_dom.
    IPR004009. Myosin_N.
    IPR002928. Myosin_tail.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00063. Myosin_head. 1 hit.
    PF02736. Myosin_N. 1 hit.
    PF01576. Myosin_tail_1. 1 hit.
    [Graphical view]
    PRINTSiPR00193. MYOSINHEAVY.
    SMARTiSM00242. MYSc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS51456. MYOSIN_MOTOR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Y2K3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVESCLLTFR AFFWWIALIK MDLSDLGEAA AFLRRSEAEL LLLQATALDG     50
    KKKCWIPDGE NAYIEAEVKG SEDDGTVIVE TADGESLSIK EDKIQQMNPP 100
    EFEMIEDMAM LTHLNEASVL HTLKRRYGQW MIYTYSGLFC VTINPYKWLP 150
    VYQKEVMAAY KGKRRSEAPP HIFAVANNAF QDMLHNRENQ SILFTGESGA 200
    GKTVNSKHII QYFATIAAMI ESRKKQGALE DQIMQANTIL EAFGNAKTLR 250
    NDNSSRFGKF IRMHFGARGM LSSVDIDIYL LEKSRVIFQQ AGERNYHIFY 300
    QILSGQKELH DLLLVSANPS DFHFCSCGAV TVESLDDAEE LLATEQAMDI 350
    LGFLPDEKYG CYKLTGAIMH FGNMKFKQKP REEQLEADGT ENADKAAFLM 400
    GINSSELVKC LIHPRIKVGN EYVTRGQTIE QVTCAVGALS KSMYERMFKW 450
    LVARINRALD AKLSRQFFIG ILDITGFEIL EYNSLEQLCI NFTNEKLQQF 500
    FNWHMFVLEQ EEYKKESIEW VSIGFGLDLQ ACIDLIEKPM GILSILEEEC 550
    MFPKATDLTF KTKLFDNHFG KSVHLQKPKP DKKKFEAHFE LVHYAGVVPY 600
    NISGWLEKNK DLLNETVVAV FQKSSNRLLA SLFENYMSTD SAIPFGEKKR 650
    KKGASFQTVA SLHKENLNKL MTNLKSTAPH FVRCINPNVN KIPGILDPYL 700
    VLQQLRCNGV LEGTRICREG FPNRLQYADF KQRYCILNPR TFPKSKFVSS 750
    RKAAEELLGS LEIDHTQYRF GITKVFFKAG FLGQLEAIRD ERLSKVFTLF 800
    QARAQGKLMR IKFQKILEER DALILIQWNI RAFMAVKNWP WMRLFFKIKP 850
    LVKSSEVGEE VAGLKEECAQ LQKALEKSEF QREELKAKQV SLTQEKNDLI 900
    LQLQAEQETL ANVEEQCEWL IKSKIQLEAR VKELSERVEE EEEINSELTA 950
    RGRKLEDECF ELKKEIDDLE TMLVKSEKEK RTTEHKVKNL TEEVEFLNED 1000
    ISKLNRAAKV VQEAHQQTLD DLHMEEEKLS SLSKANLKLE QQVDELEGAL 1050
    EQERKARMNC ERELHKLEGN LKLNRESMEN LESSQRHLAE ELRKKELELS 1100
    QMNSKVENEK GLVAQLQKTV KELQTQIKDL KEKLEAERTT RAKMERERAD 1150
    LTQDLADLNE RLEEVGGSSL AQLEITKKQE TKFQKLHRDM EEATLHFETT 1200
    SASLKKRHAD SLAELEGQVE NLQQVKQKLE KDKSDLQLEV DDLLTRVEQM 1250
    TRAKANAEKL CTLYEERLHE ATAKLDKVTQ LANDLAAQKT KLWSESGEFL 1300
    RRLEEKEALI NQLSREKSNF TRQIEDLRGQ LEKETKSQSA LAHALQKAQR 1350
    DCDLLREQYE EEQEVKAELH RTLSKVNAEM VQWRMKYENN VIQRTEDLED 1400
    AKKELAIRLQ EAAEAMGVAN ARNASLERAR HQLQLELGDA LSDLGKVRSA 1450
    AARLDQKQLQ SGKALADWKQ KHEESQALLD ASQKEVQALS TELLKLKNTY 1500
    EESIVGQETL RRENKNLQEE ISNLTNQVRE GTKNLTEMEK VKKLIEEEKT 1550
    EVQVTLEETE GALERNESKI LHFQLELLEA KAELERKLSE KDEEIENFRR 1600
    KQQCTIDSLQ SSLDSEAKSR IEVTRLKKKM EEDLNEMELQ LSCANRQVSE 1650
    ATKSLGQLQI QIKDLQMQLD DSTQLNSDLK EQVAVAERRN SLLQSELEDL 1700
    RSLQEQTERG RRLSEEELLE ATERINLFYT QNTSLLSQKK KLEADVARMQ 1750
    KEAEEVVQEC QNAEEKAKKA AIEAANLSEE LKKKQDTIAH LERTRENMEQ 1800
    TITDLQKRLA EAEQMALMGS RKQIQKLESR VRELEGELEG EIRRSAEAQR 1850
    GARRLERCIK ELTYQAEEDK KNLSRMQTQM DKLQLKVQNY KQQVEVAETQ 1900
    ANQYLSKYKK QQHELNEVKE RAEVAESQVN KLKIKAREFG KKVQEE 1946
    Length:1,946
    Mass (Da):224,619
    Last modified:May 18, 2010 - v5
    Checksum:i6CCE1836B64FC9C9
    GO

    Sequence cautioni

    The sequence BAA76844.3 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti454 – 4541R → Q.
    Corresponds to variant rs4299484 [ dbSNP | Ensembl ].
    VAR_030235
    Natural varianti504 – 5041H → Y.1 Publication
    Corresponds to variant rs9868484 [ dbSNP | Ensembl ].
    VAR_030236
    Natural varianti949 – 9491T → I.
    Corresponds to variant rs12638212 [ dbSNP | Ensembl ].
    VAR_030237
    Natural varianti1125 – 11251T → A.
    Corresponds to variant rs3900940 [ dbSNP | Ensembl ].
    VAR_030238
    Natural varianti1467 – 14671D → N.
    Corresponds to variant rs1078456 [ dbSNP | Ensembl ].
    VAR_046376

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB023217 mRNA. Translation: BAA76844.3. Different initiation.
    AC069499 Genomic DNA. No translation available.
    CCDSiCCDS43127.1.
    RefSeqiNP_055796.1. NM_014981.1.
    UniGeneiHs.731060.

    Genome annotation databases

    EnsembliENST00000273353; ENSP00000273353; ENSG00000144821.
    GeneIDi22989.
    KEGGihsa:22989.
    UCSCiuc003dxa.1. human.

    Polymorphism databases

    DMDMi296439498.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB023217 mRNA. Translation: BAA76844.3 . Different initiation.
    AC069499 Genomic DNA. No translation available.
    CCDSi CCDS43127.1.
    RefSeqi NP_055796.1. NM_014981.1.
    UniGenei Hs.731060.

    3D structure databases

    ProteinModelPortali Q9Y2K3.
    SMRi Q9Y2K3. Positions 22-973.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116637. 1 interaction.
    STRINGi 9606.ENSP00000273353.

    PTM databases

    PhosphoSitei Q9Y2K3.

    Polymorphism databases

    DMDMi 296439498.

    Proteomic databases

    PaxDbi Q9Y2K3.
    PRIDEi Q9Y2K3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000273353 ; ENSP00000273353 ; ENSG00000144821 .
    GeneIDi 22989.
    KEGGi hsa:22989.
    UCSCi uc003dxa.1. human.

    Organism-specific databases

    CTDi 22989.
    GeneCardsi GC03M108108.
    H-InvDB HIX0119155.
    HIX0200470.
    HGNCi HGNC:31073. MYH15.
    HPAi HPA034871.
    MIMi 609929. gene.
    neXtProti NX_Q9Y2K3.
    PharmGKBi PA134958635.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5022.
    HOGENOMi HOG000173959.
    HOVERGENi HBG004704.
    InParanoidi Q9Y2K3.
    KOi K10352.
    OMAi IIQYFAT.
    OrthoDBi EOG7RBZ7G.
    PhylomeDBi Q9Y2K3.
    TreeFami TF314375.

    Enzyme and pathway databases

    Reactomei REACT_147867. Translocation of GLUT4 to the plasma membrane.

    Miscellaneous databases

    GeneWikii MYH15.
    GenomeRNAii 22989.
    NextBioi 43835.
    PROi Q9Y2K3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y2K3.
    Bgeei Q9Y2K3.
    CleanExi HS_MYH15.
    Genevestigatori Q9Y2K3.

    Family and domain databases

    Gene3Di 4.10.270.10. 1 hit.
    InterProi IPR027401. Myosin-like_IQ_dom.
    IPR001609. Myosin_head_motor_dom.
    IPR004009. Myosin_N.
    IPR002928. Myosin_tail.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00063. Myosin_head. 1 hit.
    PF02736. Myosin_N. 1 hit.
    PF01576. Myosin_tail_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00193. MYOSINHEAVY.
    SMARTi SM00242. MYSc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS51456. MYOSIN_MOTOR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT TYR-504.
      Tissue: Brain.
    2. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Evolutionary implications of three novel members of the human sarcomeric myosin heavy chain gene family."
      Desjardins P.R., Burkman J.M., Shrager J.B., Allmond L.A., Stedman H.H.
      Mol. Biol. Evol. 19:375-393(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiMYH15_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y2K3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 6, 2007
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 105 of the entry and version 5 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Represents a conventional myosin. This protein should not be confused with the unconventional myosin-15 (MYO15).Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3