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Protein

Myosin-15

Gene

MYH15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Muscle contraction.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi196 – 2038ATPBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Muscle protein, Myosin

Keywords - Ligandi

Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_147867. Translocation of GLUT4 to the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-15
Alternative name(s):
Myosin heavy chain 15
Gene namesi
Name:MYH15
Synonyms:KIAA1000
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:31073. MYH15.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Thick filament

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134958635.

Polymorphism and mutation databases

BioMutaiMYH15.
DMDMi296439498.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19461946Myosin-15PRO_0000274233Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei147 – 1471N6,N6,N6-trimethyllysineSequence Analysis

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiQ9Y2K3.
PRIDEiQ9Y2K3.

PTM databases

PhosphoSiteiQ9Y2K3.

Expressioni

Gene expression databases

BgeeiQ9Y2K3.
CleanExiHS_MYH15.
GenevisibleiQ9Y2K3. HS.

Organism-specific databases

HPAiHPA034871.

Interactioni

Subunit structurei

Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).By similarity

Protein-protein interaction databases

BioGridi116637. 2 interactions.
STRINGi9606.ENSP00000273353.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2K3.
SMRiQ9Y2K3. Positions 22-853, 862-973.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini103 – 790688Myosin motorAdd
BLAST
Domaini793 – 82230IQAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni667 – 68923Actin-bindingBy similarityAdd
BLAST
Regioni769 – 78315Actin-bindingBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili853 – 19461094Sequence AnalysisAdd
BLAST

Domaini

The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.By similarity

Sequence similaritiesi

Contains 1 IQ domain.Curated
Contains 1 myosin motor domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5022.
GeneTreeiENSGT00760000118919.
HOGENOMiHOG000173959.
HOVERGENiHBG004704.
InParanoidiQ9Y2K3.
KOiK10352.
OMAiIIQYFAT.
OrthoDBiEOG7RBZ7G.
PhylomeDBiQ9Y2K3.
TreeFamiTF314375.

Family and domain databases

Gene3Di4.10.270.10. 1 hit.
InterProiIPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y2K3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVESCLLTFR AFFWWIALIK MDLSDLGEAA AFLRRSEAEL LLLQATALDG
60 70 80 90 100
KKKCWIPDGE NAYIEAEVKG SEDDGTVIVE TADGESLSIK EDKIQQMNPP
110 120 130 140 150
EFEMIEDMAM LTHLNEASVL HTLKRRYGQW MIYTYSGLFC VTINPYKWLP
160 170 180 190 200
VYQKEVMAAY KGKRRSEAPP HIFAVANNAF QDMLHNRENQ SILFTGESGA
210 220 230 240 250
GKTVNSKHII QYFATIAAMI ESRKKQGALE DQIMQANTIL EAFGNAKTLR
260 270 280 290 300
NDNSSRFGKF IRMHFGARGM LSSVDIDIYL LEKSRVIFQQ AGERNYHIFY
310 320 330 340 350
QILSGQKELH DLLLVSANPS DFHFCSCGAV TVESLDDAEE LLATEQAMDI
360 370 380 390 400
LGFLPDEKYG CYKLTGAIMH FGNMKFKQKP REEQLEADGT ENADKAAFLM
410 420 430 440 450
GINSSELVKC LIHPRIKVGN EYVTRGQTIE QVTCAVGALS KSMYERMFKW
460 470 480 490 500
LVARINRALD AKLSRQFFIG ILDITGFEIL EYNSLEQLCI NFTNEKLQQF
510 520 530 540 550
FNWHMFVLEQ EEYKKESIEW VSIGFGLDLQ ACIDLIEKPM GILSILEEEC
560 570 580 590 600
MFPKATDLTF KTKLFDNHFG KSVHLQKPKP DKKKFEAHFE LVHYAGVVPY
610 620 630 640 650
NISGWLEKNK DLLNETVVAV FQKSSNRLLA SLFENYMSTD SAIPFGEKKR
660 670 680 690 700
KKGASFQTVA SLHKENLNKL MTNLKSTAPH FVRCINPNVN KIPGILDPYL
710 720 730 740 750
VLQQLRCNGV LEGTRICREG FPNRLQYADF KQRYCILNPR TFPKSKFVSS
760 770 780 790 800
RKAAEELLGS LEIDHTQYRF GITKVFFKAG FLGQLEAIRD ERLSKVFTLF
810 820 830 840 850
QARAQGKLMR IKFQKILEER DALILIQWNI RAFMAVKNWP WMRLFFKIKP
860 870 880 890 900
LVKSSEVGEE VAGLKEECAQ LQKALEKSEF QREELKAKQV SLTQEKNDLI
910 920 930 940 950
LQLQAEQETL ANVEEQCEWL IKSKIQLEAR VKELSERVEE EEEINSELTA
960 970 980 990 1000
RGRKLEDECF ELKKEIDDLE TMLVKSEKEK RTTEHKVKNL TEEVEFLNED
1010 1020 1030 1040 1050
ISKLNRAAKV VQEAHQQTLD DLHMEEEKLS SLSKANLKLE QQVDELEGAL
1060 1070 1080 1090 1100
EQERKARMNC ERELHKLEGN LKLNRESMEN LESSQRHLAE ELRKKELELS
1110 1120 1130 1140 1150
QMNSKVENEK GLVAQLQKTV KELQTQIKDL KEKLEAERTT RAKMERERAD
1160 1170 1180 1190 1200
LTQDLADLNE RLEEVGGSSL AQLEITKKQE TKFQKLHRDM EEATLHFETT
1210 1220 1230 1240 1250
SASLKKRHAD SLAELEGQVE NLQQVKQKLE KDKSDLQLEV DDLLTRVEQM
1260 1270 1280 1290 1300
TRAKANAEKL CTLYEERLHE ATAKLDKVTQ LANDLAAQKT KLWSESGEFL
1310 1320 1330 1340 1350
RRLEEKEALI NQLSREKSNF TRQIEDLRGQ LEKETKSQSA LAHALQKAQR
1360 1370 1380 1390 1400
DCDLLREQYE EEQEVKAELH RTLSKVNAEM VQWRMKYENN VIQRTEDLED
1410 1420 1430 1440 1450
AKKELAIRLQ EAAEAMGVAN ARNASLERAR HQLQLELGDA LSDLGKVRSA
1460 1470 1480 1490 1500
AARLDQKQLQ SGKALADWKQ KHEESQALLD ASQKEVQALS TELLKLKNTY
1510 1520 1530 1540 1550
EESIVGQETL RRENKNLQEE ISNLTNQVRE GTKNLTEMEK VKKLIEEEKT
1560 1570 1580 1590 1600
EVQVTLEETE GALERNESKI LHFQLELLEA KAELERKLSE KDEEIENFRR
1610 1620 1630 1640 1650
KQQCTIDSLQ SSLDSEAKSR IEVTRLKKKM EEDLNEMELQ LSCANRQVSE
1660 1670 1680 1690 1700
ATKSLGQLQI QIKDLQMQLD DSTQLNSDLK EQVAVAERRN SLLQSELEDL
1710 1720 1730 1740 1750
RSLQEQTERG RRLSEEELLE ATERINLFYT QNTSLLSQKK KLEADVARMQ
1760 1770 1780 1790 1800
KEAEEVVQEC QNAEEKAKKA AIEAANLSEE LKKKQDTIAH LERTRENMEQ
1810 1820 1830 1840 1850
TITDLQKRLA EAEQMALMGS RKQIQKLESR VRELEGELEG EIRRSAEAQR
1860 1870 1880 1890 1900
GARRLERCIK ELTYQAEEDK KNLSRMQTQM DKLQLKVQNY KQQVEVAETQ
1910 1920 1930 1940
ANQYLSKYKK QQHELNEVKE RAEVAESQVN KLKIKAREFG KKVQEE
Length:1,946
Mass (Da):224,619
Last modified:May 18, 2010 - v5
Checksum:i6CCE1836B64FC9C9
GO

Sequence cautioni

The sequence BAA76844.3 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti454 – 4541R → Q.
Corresponds to variant rs4299484 [ dbSNP | Ensembl ].
VAR_030235
Natural varianti504 – 5041H → Y.1 Publication
Corresponds to variant rs9868484 [ dbSNP | Ensembl ].
VAR_030236
Natural varianti949 – 9491T → I.
Corresponds to variant rs12638212 [ dbSNP | Ensembl ].
VAR_030237
Natural varianti1125 – 11251T → A.
Corresponds to variant rs3900940 [ dbSNP | Ensembl ].
VAR_030238
Natural varianti1467 – 14671D → N.
Corresponds to variant rs1078456 [ dbSNP | Ensembl ].
VAR_046376

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023217 mRNA. Translation: BAA76844.3. Different initiation.
AC069499 Genomic DNA. No translation available.
CCDSiCCDS43127.1.
RefSeqiNP_055796.1. NM_014981.1.
UniGeneiHs.731060.

Genome annotation databases

EnsembliENST00000273353; ENSP00000273353; ENSG00000144821.
GeneIDi22989.
KEGGihsa:22989.
UCSCiuc003dxa.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023217 mRNA. Translation: BAA76844.3. Different initiation.
AC069499 Genomic DNA. No translation available.
CCDSiCCDS43127.1.
RefSeqiNP_055796.1. NM_014981.1.
UniGeneiHs.731060.

3D structure databases

ProteinModelPortaliQ9Y2K3.
SMRiQ9Y2K3. Positions 22-853, 862-973.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116637. 2 interactions.
STRINGi9606.ENSP00000273353.

PTM databases

PhosphoSiteiQ9Y2K3.

Polymorphism and mutation databases

BioMutaiMYH15.
DMDMi296439498.

Proteomic databases

PaxDbiQ9Y2K3.
PRIDEiQ9Y2K3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000273353; ENSP00000273353; ENSG00000144821.
GeneIDi22989.
KEGGihsa:22989.
UCSCiuc003dxa.1. human.

Organism-specific databases

CTDi22989.
GeneCardsiGC03M108108.
H-InvDBHIX0119155.
HIX0200470.
HGNCiHGNC:31073. MYH15.
HPAiHPA034871.
MIMi609929. gene.
neXtProtiNX_Q9Y2K3.
PharmGKBiPA134958635.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5022.
GeneTreeiENSGT00760000118919.
HOGENOMiHOG000173959.
HOVERGENiHBG004704.
InParanoidiQ9Y2K3.
KOiK10352.
OMAiIIQYFAT.
OrthoDBiEOG7RBZ7G.
PhylomeDBiQ9Y2K3.
TreeFamiTF314375.

Enzyme and pathway databases

ReactomeiREACT_147867. Translocation of GLUT4 to the plasma membrane.

Miscellaneous databases

GeneWikiiMYH15.
GenomeRNAii22989.
NextBioi43835.
PROiQ9Y2K3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y2K3.
CleanExiHS_MYH15.
GenevisibleiQ9Y2K3. HS.

Family and domain databases

Gene3Di4.10.270.10. 1 hit.
InterProiIPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT TYR-504.
    Tissue: Brain.
  2. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Evolutionary implications of three novel members of the human sarcomeric myosin heavy chain gene family."
    Desjardins P.R., Burkman J.M., Shrager J.B., Allmond L.A., Stedman H.H.
    Mol. Biol. Evol. 19:375-393(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiMYH15_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2K3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: May 18, 2010
Last modified: June 24, 2015
This is version 110 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Represents a conventional myosin. This protein should not be confused with the unconventional myosin-15 (MYO15).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.