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Q9Y2K3 (MYH15_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Myosin-15
Alternative name(s):
Myosin heavy chain 15
Gene names
Name:MYH15
Synonyms:KIAA1000
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1946 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Muscle contraction By similarity.

Subunit structure

Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2) By similarity.

Subcellular location

Cytoplasmmyofibril. Note: Thick filaments of the myofibrils.

Domain

The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils By similarity.

Sequence similarities

Contains 1 IQ domain.

Contains 1 myosin head-like domain.

Caution

Represents a conventional myosin. This protein should not be confused with the unconventional myosin-15 (MYO15).

Sequence caution

The sequence BAA76844.3 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
   Cellular componentCytoplasm
Thick filament
   Coding sequence diversityPolymorphism
   DomainCoiled coil
   LigandActin-binding
ATP-binding
Calmodulin-binding
Nucleotide-binding
   Molecular functionMotor protein
Muscle protein
Myosin
   PTMMethylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentmyofibril

Inferred from electronic annotation. Source: UniProtKB-SubCell

myosin filament

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

motor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 19461946Myosin-15
PRO_0000274233

Regions

Domain1 – 792792Myosin head-like
Domain793 – 82230IQ
Nucleotide binding196 – 2038ATP By similarity
Region667 – 68923Actin-binding By similarity
Region769 – 78315Actin-binding By similarity
Coiled coil853 – 19461094 Potential

Amino acid modifications

Modified residue1471N6,N6,N6-trimethyllysine Potential

Natural variations

Natural variant4541R → Q.
Corresponds to variant rs4299484 [ dbSNP | Ensembl ].
VAR_030235
Natural variant5041H → Y. Ref.1
Corresponds to variant rs9868484 [ dbSNP | Ensembl ].
VAR_030236
Natural variant9491T → I.
Corresponds to variant rs12638212 [ dbSNP | Ensembl ].
VAR_030237
Natural variant11251T → A.
Corresponds to variant rs3900940 [ dbSNP | Ensembl ].
VAR_030238
Natural variant14671D → N.
Corresponds to variant rs1078456 [ dbSNP | Ensembl ].
VAR_046376

Sequences

Sequence LengthMass (Da)Tools
Q9Y2K3 [UniParc].

Last modified May 18, 2010. Version 5.
Checksum: 6CCE1836B64FC9C9

FASTA1,946224,619
        10         20         30         40         50         60 
MVESCLLTFR AFFWWIALIK MDLSDLGEAA AFLRRSEAEL LLLQATALDG KKKCWIPDGE 

        70         80         90        100        110        120 
NAYIEAEVKG SEDDGTVIVE TADGESLSIK EDKIQQMNPP EFEMIEDMAM LTHLNEASVL 

       130        140        150        160        170        180 
HTLKRRYGQW MIYTYSGLFC VTINPYKWLP VYQKEVMAAY KGKRRSEAPP HIFAVANNAF 

       190        200        210        220        230        240 
QDMLHNRENQ SILFTGESGA GKTVNSKHII QYFATIAAMI ESRKKQGALE DQIMQANTIL 

       250        260        270        280        290        300 
EAFGNAKTLR NDNSSRFGKF IRMHFGARGM LSSVDIDIYL LEKSRVIFQQ AGERNYHIFY 

       310        320        330        340        350        360 
QILSGQKELH DLLLVSANPS DFHFCSCGAV TVESLDDAEE LLATEQAMDI LGFLPDEKYG 

       370        380        390        400        410        420 
CYKLTGAIMH FGNMKFKQKP REEQLEADGT ENADKAAFLM GINSSELVKC LIHPRIKVGN 

       430        440        450        460        470        480 
EYVTRGQTIE QVTCAVGALS KSMYERMFKW LVARINRALD AKLSRQFFIG ILDITGFEIL 

       490        500        510        520        530        540 
EYNSLEQLCI NFTNEKLQQF FNWHMFVLEQ EEYKKESIEW VSIGFGLDLQ ACIDLIEKPM 

       550        560        570        580        590        600 
GILSILEEEC MFPKATDLTF KTKLFDNHFG KSVHLQKPKP DKKKFEAHFE LVHYAGVVPY 

       610        620        630        640        650        660 
NISGWLEKNK DLLNETVVAV FQKSSNRLLA SLFENYMSTD SAIPFGEKKR KKGASFQTVA 

       670        680        690        700        710        720 
SLHKENLNKL MTNLKSTAPH FVRCINPNVN KIPGILDPYL VLQQLRCNGV LEGTRICREG 

       730        740        750        760        770        780 
FPNRLQYADF KQRYCILNPR TFPKSKFVSS RKAAEELLGS LEIDHTQYRF GITKVFFKAG 

       790        800        810        820        830        840 
FLGQLEAIRD ERLSKVFTLF QARAQGKLMR IKFQKILEER DALILIQWNI RAFMAVKNWP 

       850        860        870        880        890        900 
WMRLFFKIKP LVKSSEVGEE VAGLKEECAQ LQKALEKSEF QREELKAKQV SLTQEKNDLI 

       910        920        930        940        950        960 
LQLQAEQETL ANVEEQCEWL IKSKIQLEAR VKELSERVEE EEEINSELTA RGRKLEDECF 

       970        980        990       1000       1010       1020 
ELKKEIDDLE TMLVKSEKEK RTTEHKVKNL TEEVEFLNED ISKLNRAAKV VQEAHQQTLD 

      1030       1040       1050       1060       1070       1080 
DLHMEEEKLS SLSKANLKLE QQVDELEGAL EQERKARMNC ERELHKLEGN LKLNRESMEN 

      1090       1100       1110       1120       1130       1140 
LESSQRHLAE ELRKKELELS QMNSKVENEK GLVAQLQKTV KELQTQIKDL KEKLEAERTT 

      1150       1160       1170       1180       1190       1200 
RAKMERERAD LTQDLADLNE RLEEVGGSSL AQLEITKKQE TKFQKLHRDM EEATLHFETT 

      1210       1220       1230       1240       1250       1260 
SASLKKRHAD SLAELEGQVE NLQQVKQKLE KDKSDLQLEV DDLLTRVEQM TRAKANAEKL 

      1270       1280       1290       1300       1310       1320 
CTLYEERLHE ATAKLDKVTQ LANDLAAQKT KLWSESGEFL RRLEEKEALI NQLSREKSNF 

      1330       1340       1350       1360       1370       1380 
TRQIEDLRGQ LEKETKSQSA LAHALQKAQR DCDLLREQYE EEQEVKAELH RTLSKVNAEM 

      1390       1400       1410       1420       1430       1440 
VQWRMKYENN VIQRTEDLED AKKELAIRLQ EAAEAMGVAN ARNASLERAR HQLQLELGDA 

      1450       1460       1470       1480       1490       1500 
LSDLGKVRSA AARLDQKQLQ SGKALADWKQ KHEESQALLD ASQKEVQALS TELLKLKNTY 

      1510       1520       1530       1540       1550       1560 
EESIVGQETL RRENKNLQEE ISNLTNQVRE GTKNLTEMEK VKKLIEEEKT EVQVTLEETE 

      1570       1580       1590       1600       1610       1620 
GALERNESKI LHFQLELLEA KAELERKLSE KDEEIENFRR KQQCTIDSLQ SSLDSEAKSR 

      1630       1640       1650       1660       1670       1680 
IEVTRLKKKM EEDLNEMELQ LSCANRQVSE ATKSLGQLQI QIKDLQMQLD DSTQLNSDLK 

      1690       1700       1710       1720       1730       1740 
EQVAVAERRN SLLQSELEDL RSLQEQTERG RRLSEEELLE ATERINLFYT QNTSLLSQKK 

      1750       1760       1770       1780       1790       1800 
KLEADVARMQ KEAEEVVQEC QNAEEKAKKA AIEAANLSEE LKKKQDTIAH LERTRENMEQ 

      1810       1820       1830       1840       1850       1860 
TITDLQKRLA EAEQMALMGS RKQIQKLESR VRELEGELEG EIRRSAEAQR GARRLERCIK 

      1870       1880       1890       1900       1910       1920 
ELTYQAEEDK KNLSRMQTQM DKLQLKVQNY KQQVEVAETQ ANQYLSKYKK QQHELNEVKE 

      1930       1940 
RAEVAESQVN KLKIKAREFG KKVQEE 

« Hide

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT TYR-504.
Tissue: Brain.
[2]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Evolutionary implications of three novel members of the human sarcomeric myosin heavy chain gene family."
Desjardins P.R., Burkman J.M., Shrager J.B., Allmond L.A., Stedman H.H.
Mol. Biol. Evol. 19:375-393(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[4]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB023217 mRNA. Translation: BAA76844.3. Different initiation.
AC069499 Genomic DNA. No translation available.
RefSeqNP_055796.1. NM_014981.1.
UniGeneHs.731060.

3D structure databases

ProteinModelPortalQ9Y2K3.
SMRQ9Y2K3. Positions 22-853, 862-973.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116637. 1 interaction.
STRING9606.ENSP00000273353.

PTM databases

PhosphoSiteQ9Y2K3.

Polymorphism databases

DMDM296439498.

Proteomic databases

PaxDbQ9Y2K3.
PRIDEQ9Y2K3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000273353; ENSP00000273353; ENSG00000144821.
GeneID22989.
KEGGhsa:22989.
UCSCuc003dxa.1. human.

Organism-specific databases

CTD22989.
GeneCardsGC03M108108.
H-InvDBHIX0119155.
HIX0200470.
HGNCHGNC:31073. MYH15.
HPAHPA034871.
MIM609929. gene.
neXtProtNX_Q9Y2K3.
PharmGKBPA134958635.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5022.
HOGENOMHOG000173959.
HOVERGENHBG004704.
InParanoidQ9Y2K3.
KOK10352.
OMAIIQYFAT.
OrthoDBEOG7RBZ7G.
PhylomeDBQ9Y2K3.
TreeFamTF314375.

Enzyme and pathway databases

ReactomeREACT_11123. Membrane Trafficking.

Gene expression databases

ArrayExpressQ9Y2K3.
BgeeQ9Y2K3.
CleanExHS_MYH15.
GenevestigatorQ9Y2K3.

Family and domain databases

Gene3D4.10.270.10. 1 hit.
InterProIPR027401. Myosin-like_IQ_dom.
IPR015650. Myosin_1/23/4/6/7/8/13/15.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERPTHR13140:SF22. PTHR13140:SF22. 1 hit.
PfamPF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view]
PRINTSPR00193. MYOSINHEAVY.
SMARTSM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Other

GeneWikiMYH15.
GenomeRNAi22989.
NextBio43835.
PROQ9Y2K3.
SOURCESearch...

Entry information

Entry nameMYH15_HUMAN
AccessionPrimary (citable) accession number: Q9Y2K3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: May 18, 2010
Last modified: April 16, 2014
This is version 100 of the entry and version 5 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM