Q9Y2K3 (MYH15_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Myosin-15

Alternative name(s):
Myosin heavy chain 15

Gene names

Name:	MYH15
Synonyms:	KIAA1000

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1946 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Muscle contraction By similarity.
Subunit structure	Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2) By similarity.
Subcellular location	Cytoplasm › myofibril. Note: Thick filaments of the myofibrils.
Domain	The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils By similarity.
Sequence similarities	Contains 1 IQ domain. Contains 1 myosin head-like domain.
Caution	Represents a conventional myosin. This protein should not be confused with the unconventional myosin-15 (MYO15).
Sequence caution	The sequence BAA76844.3 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Cellular component	Cytoplasm Thick filament
Coding sequence diversity	Polymorphism
Domain	Coiled coil
Ligand	ATP-binding Actin-binding Calmodulin-binding Nucleotide-binding
Molecular function	Motor protein Muscle protein Myosin
PTM	Methylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	myofibril Inferred from electronic annotation. Source: UniProtKB-SubCell myosin filament Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW motor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1946	1946	Myosin-15		PRO_0000274233
Regions
	Domain	1 – 792	792	Myosin head-like
	Domain	793 – 822	30	IQ
	Nucleotide binding	196 – 203	8	ATP By similarity
	Region	667 – 689	23	Actin-binding By similarity
	Region	769 – 783	15	Actin-binding By similarity
	Coiled coil	853 – 1946	1094	Potential
Amino acid modifications
	Modified residue	147	1	N6,N6,N6-trimethyllysine Potential
Natural variations
	Natural variant	454	1	R → Q. Corresponds to variant rs4299484 [ dbSNP | Ensembl ].		VAR_030235
	Natural variant	504	1	H → Y. Ref.1 Corresponds to variant rs9868484 [ dbSNP | Ensembl ].		VAR_030236
	Natural variant	949	1	T → I. Corresponds to variant rs12638212 [ dbSNP | Ensembl ].		VAR_030237
	Natural variant	1125	1	T → A. Corresponds to variant rs3900940 [ dbSNP | Ensembl ].		VAR_030238
	Natural variant	1467	1	D → N. Corresponds to variant rs1078456 [ dbSNP | Ensembl ].		VAR_046376

Sequences

	Sequence		Length	Mass (Da)
	Q9Y2K3 [UniParc]. Last modified May 18, 2010. Version 5. Checksum: 6CCE1836B64FC9C9	FASTA	1,946	224,619
	10 20 30 40 50 60 MVESCLLTFR AFFWWIALIK MDLSDLGEAA AFLRRSEAEL LLLQATALDG KKKCWIPDGE 70 80 90 100 110 120 NAYIEAEVKG SEDDGTVIVE TADGESLSIK EDKIQQMNPP EFEMIEDMAM LTHLNEASVL 130 140 150 160 170 180 HTLKRRYGQW MIYTYSGLFC VTINPYKWLP VYQKEVMAAY KGKRRSEAPP HIFAVANNAF 190 200 210 220 230 240 QDMLHNRENQ SILFTGESGA GKTVNSKHII QYFATIAAMI ESRKKQGALE DQIMQANTIL 250 260 270 280 290 300 EAFGNAKTLR NDNSSRFGKF IRMHFGARGM LSSVDIDIYL LEKSRVIFQQ AGERNYHIFY 310 320 330 340 350 360 QILSGQKELH DLLLVSANPS DFHFCSCGAV TVESLDDAEE LLATEQAMDI LGFLPDEKYG 370 380 390 400 410 420 CYKLTGAIMH FGNMKFKQKP REEQLEADGT ENADKAAFLM GINSSELVKC LIHPRIKVGN 430 440 450 460 470 480 EYVTRGQTIE QVTCAVGALS KSMYERMFKW LVARINRALD AKLSRQFFIG ILDITGFEIL 490 500 510 520 530 540 EYNSLEQLCI NFTNEKLQQF FNWHMFVLEQ EEYKKESIEW VSIGFGLDLQ ACIDLIEKPM 550 560 570 580 590 600 GILSILEEEC MFPKATDLTF KTKLFDNHFG KSVHLQKPKP DKKKFEAHFE LVHYAGVVPY 610 620 630 640 650 660 NISGWLEKNK DLLNETVVAV FQKSSNRLLA SLFENYMSTD SAIPFGEKKR KKGASFQTVA 670 680 690 700 710 720 SLHKENLNKL MTNLKSTAPH FVRCINPNVN KIPGILDPYL VLQQLRCNGV LEGTRICREG 730 740 750 760 770 780 FPNRLQYADF KQRYCILNPR TFPKSKFVSS RKAAEELLGS LEIDHTQYRF GITKVFFKAG 790 800 810 820 830 840 FLGQLEAIRD ERLSKVFTLF QARAQGKLMR IKFQKILEER DALILIQWNI RAFMAVKNWP 850 860 870 880 890 900 WMRLFFKIKP LVKSSEVGEE VAGLKEECAQ LQKALEKSEF QREELKAKQV SLTQEKNDLI 910 920 930 940 950 960 LQLQAEQETL ANVEEQCEWL IKSKIQLEAR VKELSERVEE EEEINSELTA RGRKLEDECF 970 980 990 1000 1010 1020 ELKKEIDDLE TMLVKSEKEK RTTEHKVKNL TEEVEFLNED ISKLNRAAKV VQEAHQQTLD 1030 1040 1050 1060 1070 1080 DLHMEEEKLS SLSKANLKLE QQVDELEGAL EQERKARMNC ERELHKLEGN LKLNRESMEN 1090 1100 1110 1120 1130 1140 LESSQRHLAE ELRKKELELS QMNSKVENEK GLVAQLQKTV KELQTQIKDL KEKLEAERTT 1150 1160 1170 1180 1190 1200 RAKMERERAD LTQDLADLNE RLEEVGGSSL AQLEITKKQE TKFQKLHRDM EEATLHFETT 1210 1220 1230 1240 1250 1260 SASLKKRHAD SLAELEGQVE NLQQVKQKLE KDKSDLQLEV DDLLTRVEQM TRAKANAEKL 1270 1280 1290 1300 1310 1320 CTLYEERLHE ATAKLDKVTQ LANDLAAQKT KLWSESGEFL RRLEEKEALI NQLSREKSNF 1330 1340 1350 1360 1370 1380 TRQIEDLRGQ LEKETKSQSA LAHALQKAQR DCDLLREQYE EEQEVKAELH RTLSKVNAEM 1390 1400 1410 1420 1430 1440 VQWRMKYENN VIQRTEDLED AKKELAIRLQ EAAEAMGVAN ARNASLERAR HQLQLELGDA 1450 1460 1470 1480 1490 1500 LSDLGKVRSA AARLDQKQLQ SGKALADWKQ KHEESQALLD ASQKEVQALS TELLKLKNTY 1510 1520 1530 1540 1550 1560 EESIVGQETL RRENKNLQEE ISNLTNQVRE GTKNLTEMEK VKKLIEEEKT EVQVTLEETE 1570 1580 1590 1600 1610 1620 GALERNESKI LHFQLELLEA KAELERKLSE KDEEIENFRR KQQCTIDSLQ SSLDSEAKSR 1630 1640 1650 1660 1670 1680 IEVTRLKKKM EEDLNEMELQ LSCANRQVSE ATKSLGQLQI QIKDLQMQLD DSTQLNSDLK 1690 1700 1710 1720 1730 1740 EQVAVAERRN SLLQSELEDL RSLQEQTERG RRLSEEELLE ATERINLFYT QNTSLLSQKK 1750 1760 1770 1780 1790 1800 KLEADVARMQ KEAEEVVQEC QNAEEKAKKA AIEAANLSEE LKKKQDTIAH LERTRENMEQ 1810 1820 1830 1840 1850 1860 TITDLQKRLA EAEQMALMGS RKQIQKLESR VRELEGELEG EIRRSAEAQR GARRLERCIK 1870 1880 1890 1900 1910 1920 ELTYQAEEDK KNLSRMQTQM DKLQLKVQNY KQQVEVAETQ ANQYLSKYKK QQHELNEVKE 1930 1940 RAEVAESQVN KLKIKAREFG KKVQEE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT TYR-504. Tissue: Brain.
[2]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Evolutionary implications of three novel members of the human sarcomeric myosin heavy chain gene family." Desjardins P.R., Burkman J.M., Shrager J.B., Allmond L.A., Stedman H.H. Mol. Biol. Evol. 19:375-393(2002) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[4]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB023217 mRNA. Translation: BAA76844.3. Different initiation. AC069499 Genomic DNA. No translation available.
IPI	IPI00180408.
RefSeq	NP_055796.1. NM_014981.1.
UniGene	Hs.731060.
3D structure databases
HSSP	HSSP built from PDB template 1KQM based on UniProtKB P24733.
ProteinModelPortal	Q9Y2K3.
SMR	Q9Y2K3. Positions 22-973.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000273353.
PTM databases
PhosphoSite	Q9Y2K3.
Polymorphism databases
DMDM	296439498.
Proteomic databases
PaxDb	Q9Y2K3.
PRIDE	Q9Y2K3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000273353; ENSP00000273353; ENSG00000144821.
GeneID	22989.
KEGG	hsa:22989.
UCSC	uc003dxa.1. human.
Organism-specific databases
CTD	22989.
GeneCards	GC03M108108.
H-InvDB	HIX0119155. HIX0200470.
HGNC	HGNC:31073. MYH15.
HPA	HPA034871.
MIM	609929. gene.
neXtProt	NX_Q9Y2K3.
PharmGKB	PA134958635.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5022.
HOGENOM	HOG000173959.
HOVERGEN	HBG004704.
InParanoid	Q9Y2K3.
KO	K10352.
OMA	IIQYFAT.
OrthoDB	EOG42V8FB.
PhylomeDB	Q9Y2K3.
Gene expression databases
ArrayExpress	Q9Y2K3.
Bgee	Q9Y2K3.
CleanEx	HS_MYH15.
Genevestigator	Q9Y2K3.
Family and domain databases
InterPro	IPR015650. Myosin_1/23/4/7/8/13/15. IPR001609. Myosin_head_motor_dom. IPR004009. Myosin_N. IPR002928. Myosin_tail. [Graphical view]
PANTHER	PTHR13140:SF22. PTHR13140:SF22. 1 hit.
Pfam	PF00063. Myosin_head. 1 hit. PF02736. Myosin_N. 1 hit. PF01576. Myosin_tail_1. 1 hit. [Graphical view]
PRINTS	PR00193. MYOSINHEAVY.
SMART	SM00242. MYSc. 1 hit. [Graphical view]
PROSITE	PS50096. IQ. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	22989.
NextBio	43835.
SOURCE	Search...

Entry information

Entry name

MYH15_HUMAN

Accession

Primary (citable) accession number: Q9Y2K3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 6, 2007
Last sequence update:	May 18, 2010
Last modified:	May 1, 2013
This is version 91 of the entry and version 5 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.