SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9Y2J8

- PADI2_HUMAN

UniProt

Q9Y2J8 - PADI2_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Protein-arginine deiminase type-2
Gene
PADI2, KIAA0994, PDI2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the deimination of arginine residues of proteins By similarity.

Catalytic activityi

Protein L-arginine + H2O = protein L-citrulline + NH3.

Cofactori

Calcium By similarity.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. estrogen receptor binding Source: UniProt
  3. protein-arginine deiminase activity Source: UniProt

GO - Biological processi

  1. chromatin-mediated maintenance of transcription Source: UniProt
  2. histone H3-R26 citrullination Source: UniProt
  3. intracellular estrogen receptor signaling pathway Source: UniProt
  4. negative regulation of chemokine-mediated signaling pathway Source: UniProt
  5. negative regulation of lymphocyte chemotaxis Source: UniProt
  6. protein citrullination Source: UniProt
  7. regulation of chromatin disassembly Source: UniProt
  8. substantia nigra development Source: UniProt
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BioCyciMetaCyc:HS04094-MONOMER.
BRENDAi3.5.3.15. 2681.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-arginine deiminase type-2 (EC:3.5.3.15)
Alternative name(s):
PAD-H19
Peptidylarginine deiminase II
Protein-arginine deiminase type II
Gene namesi
Name:PADI2
Synonyms:KIAA0994, PDI2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:18341. PADI2.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProt
  2. extracellular vesicular exosome Source: UniProt
  3. transcriptionally active chromatin Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32900.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 665665Protein-arginine deiminase type-2
PRO_0000220026Add
BLAST

Proteomic databases

MaxQBiQ9Y2J8.
PaxDbiQ9Y2J8.
PRIDEiQ9Y2J8.

PTM databases

PhosphoSiteiQ9Y2J8.

Expressioni

Gene expression databases

ArrayExpressiQ9Y2J8.
BgeeiQ9Y2J8.
CleanExiHS_PADI2.
GenevestigatoriQ9Y2J8.

Organism-specific databases

HPAiCAB012222.

Interactioni

Protein-protein interaction databases

BioGridi116404. 1 interaction.
IntActiQ9Y2J8. 1 interaction.
STRINGi9606.ENSP00000364635.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2J8.
SMRiQ9Y2J8. Positions 7-665.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG42085.
HOGENOMiHOG000220908.
HOVERGENiHBG053016.
InParanoidiQ9Y2J8.
KOiK01481.
OMAiCLETHVR.
OrthoDBiEOG7P5T09.
PhylomeDBiQ9Y2J8.
TreeFamiTF331952.

Family and domain databases

InterProiIPR008972. Cupredoxin.
IPR004303. PAD.
IPR013530. PAD_C.
IPR013732. PAD_N.
IPR013733. Prot_Arg_deaminase_cen_dom.
IPR016296. Protein-arginine_deiminase_sub.
[Graphical view]
PANTHERiPTHR10837. PTHR10837. 1 hit.
PfamiPF03068. PAD. 1 hit.
PF08527. PAD_M. 1 hit.
PF08526. PAD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF001247. Protein-arginine_deiminase. 1 hit.
SUPFAMiSSF110083. SSF110083. 1 hit.
SSF49503. SSF49503. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Y2J8-1 [UniParc]FASTAAdd to Basket

« Hide

MLRERTVRLQ YGSRVEAVYV LGTYLWTDVY SAAPAGAQTF SLKHSEHVWV    50
EVVRDGEAEE VATNGKQRWL LSPSTTLRVT MSQASTEASS DKVTVNYYDE 100
EGSIPIDQAG LFLTAIEISL DVDADRDGVV EKNNPKKASW TWGPEGQGAI 150
LLVNCDRETP WLPKEDCRDE KVYSKEDLKD MSQMILRTKG PDRLPAGYEI 200
VLYISMSDSD KVGVFYVENP FFGQRYIHIL GRRKLYHVVK YTGGSAELLF 250
FVEGLCFPDE GFSGLVSIHV SLLEYMAQDI PLTPIFTDTV IFRIAPWIMT 300
PNILPPVSVF VCCMKDNYLF LKEVKNLVEK TNCELKVCFQ YLNRGDRWIQ 350
DEIEFGYIEA PHKGFPVVLD SPRDGNLKDF PVKELLGPDF GYVTREPLFE 400
SVTSLDSFGN LEVSPPVTVN GKTYPLGRIL IGSSFPLSGG RRMTKVVRDF 450
LKAQQVQAPV ELYSDWLTVG HVDEFMSFVP IPGTKKFLLL MASTSACYKL 500
FREKQKDGHG EAIMFKGLGG MSSKRITINK ILSNESLVQE NLYFQRCLDW 550
NRDILKKELG LTEQDIIDLP ALFKMDEDHR ARAFFPNMVN MIVLDKDLGI 600
PKPFGPQVEE ECCLEMHVRG LLEPLGLECT FIDDISAYHK FLGEVHCGTN 650
VRRKPFTFKW WHMVP 665
Length:665
Mass (Da):75,564
Last modified:May 30, 2000 - v2
Checksum:i8D417A87A02D6839
GO

Sequence cautioni

The sequence BAA76838.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti661 – 6611W → L in BAA82557. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB030176 mRNA. Translation: BAA82557.1.
AJ549502 Genomic DNA. Translation: CAE47740.1.
AB023211 mRNA. Translation: BAA76838.1. Different initiation.
AL049569 Genomic DNA. Translation: CAB96821.1.
CCDSiCCDS177.1.
RefSeqiNP_031391.2. NM_007365.2.
UniGeneiHs.33455.

Genome annotation databases

EnsembliENST00000375486; ENSP00000364635; ENSG00000117115.
GeneIDi11240.
KEGGihsa:11240.
UCSCiuc001baf.3. human.

Polymorphism databases

DMDMi7531171.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB030176 mRNA. Translation: BAA82557.1 .
AJ549502 Genomic DNA. Translation: CAE47740.1 .
AB023211 mRNA. Translation: BAA76838.1 . Different initiation.
AL049569 Genomic DNA. Translation: CAB96821.1 .
CCDSi CCDS177.1.
RefSeqi NP_031391.2. NM_007365.2.
UniGenei Hs.33455.

3D structure databases

ProteinModelPortali Q9Y2J8.
SMRi Q9Y2J8. Positions 7-665.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116404. 1 interaction.
IntActi Q9Y2J8. 1 interaction.
STRINGi 9606.ENSP00000364635.

Chemistry

BindingDBi Q9Y2J8.
ChEMBLi CHEMBL1909487.
DrugBanki DB00155. L-Citrulline.

PTM databases

PhosphoSitei Q9Y2J8.

Polymorphism databases

DMDMi 7531171.

Proteomic databases

MaxQBi Q9Y2J8.
PaxDbi Q9Y2J8.
PRIDEi Q9Y2J8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000375486 ; ENSP00000364635 ; ENSG00000117115 .
GeneIDi 11240.
KEGGi hsa:11240.
UCSCi uc001baf.3. human.

Organism-specific databases

CTDi 11240.
GeneCardsi GC01M017393.
HGNCi HGNC:18341. PADI2.
HPAi CAB012222.
MIMi 607935. gene.
neXtProti NX_Q9Y2J8.
PharmGKBi PA32900.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG42085.
HOGENOMi HOG000220908.
HOVERGENi HBG053016.
InParanoidi Q9Y2J8.
KOi K01481.
OMAi CLETHVR.
OrthoDBi EOG7P5T09.
PhylomeDBi Q9Y2J8.
TreeFami TF331952.

Enzyme and pathway databases

BioCyci MetaCyc:HS04094-MONOMER.
BRENDAi 3.5.3.15. 2681.

Miscellaneous databases

GeneWikii PADI2.
GenomeRNAii 11240.
NextBioi 42778.
PROi Q9Y2J8.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9Y2J8.
Bgeei Q9Y2J8.
CleanExi HS_PADI2.
Genevestigatori Q9Y2J8.

Family and domain databases

InterProi IPR008972. Cupredoxin.
IPR004303. PAD.
IPR013530. PAD_C.
IPR013732. PAD_N.
IPR013733. Prot_Arg_deaminase_cen_dom.
IPR016296. Protein-arginine_deiminase_sub.
[Graphical view ]
PANTHERi PTHR10837. PTHR10837. 1 hit.
Pfami PF03068. PAD. 1 hit.
PF08527. PAD_M. 1 hit.
PF08526. PAD_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF001247. Protein-arginine_deiminase. 1 hit.
SUPFAMi SSF110083. SSF110083. 1 hit.
SSF49503. SSF49503. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human peptidylarginine deiminase type II: molecular cloning, gene organization, and expression in human skin."
    Ishigami A., Ohsawa T., Asaga H., Akiyama K., Kuramoto M., Maruyama N.
    Arch. Biochem. Biophys. 407:25-31(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
    Tissue: Skin.
  2. "Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6."
    Chavanas S., Mechin M.-C., Takahara H., Kawada A., Nachat R., Serre G., Simon M.
    Gene 330:19-27(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiPADI2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2J8
Secondary accession number(s): Q9UPN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: July 9, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi