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Reviewed, UniProtKB/Swiss-Prot Q9Y2J4 (AMOL2_HUMAN)

Last modified January 19, 2010. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Angiomotin-like protein 2
Alternative name(s):
    Leman coiled-coil protein
      Short name=LCCP
Gene names
Name: AMOTL2
Synonyms: KIAA0989
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length779 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Sequence similarities

Belongs to the angiomotin family.

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Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
   PTMPhosphoprotein
   Technical termComplete proteome
Gene Ontology (GO)
None. [Check GOA]

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Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9Y2J4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9Y2J4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     701-701: T → TA
Isoform 3 (identifier: Q9Y2J4-3)

The sequence of this isoform differs from the canonical sequence as follows:
     525-526: Missing.
Note: No experimental confirmation available.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 779779Angiomotin-like protein 2
PRO_0000190672

Regions

Coiled coil308 – 581274 Potential
Motif776 – 7794PDZ-binding

Amino acid modifications

Modified residue7591Phosphoserine Ref.8

Natural variations

Alternative sequence525 – 5262Missing in isoform 3.
VSP_037826
Alternative sequence7011T → TA in isoform 2.
VSP_015711
Natural variant2271T → I: dbSNP rs35377537.
VAR_055497
Natural variant3421A → P: dbSNP rs2303635.
VAR_055498
Natural variant4151G → S: dbSNP rs2241559.
VAR_055499
Natural variant7311D → E: dbSNP rs1353776. Ref.7
VAR_023535

Experimental info

Sequence conflict6801Q → K in AAD56361. Ref.4

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Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified September 27, 2005. Version 2.
Checksum: 679D3DF3A7757CEF

FASTA77985,750
        10         20         30         40         50         60 
MRTLEDSSGT VLHRLIQEQL RYGNLTETRT LLAIQQQALR GGAGTGGTGS PQASLEILAP 

        70         80         90        100        110        120 
EDSQVLQQAT RQEPQGQEHQ GGENHLAENT LYRLCPQPSK GEELPTYEEA KAHSQYYAAQ 

       130        140        150        160        170        180 
QAGTRPHAGD RDPRGAPGGS RRQDEALREL RHGHVRSLSE RLLQLSLERN GARAPSHMSS 

       190        200        210        220        230        240 
SHSFPQLARN QQGPPLRGPP AEGPESRGPP PQYPHVVLAH ETTTAVTDPR YRARGSPHFQ 

       250        260        270        280        290        300 
HAEVRILQAQ VPPVFLQQQQ QYQYLQQSQE HPPPPHPAAL GHGPLSSLSP PAVEGPVSAQ 

       310        320        330        340        350        360 
ASSATSGSAH LAQMEAVLRE NARLQRDNER LQRELESSAE KAGRIEKLES EIQRLSEAHE 

       370        380        390        400        410        420 
SLTRASSKRE ALEKTMRNKM DSEMRRLQDF NRDLRERLES ANRRLASKTQ EAQAGSQDMV 

       430        440        450        460        470        480 
AKLLAQSYEQ QQEQEKLERE MALLRGAIED QRRRAELLEQ ALGNAQGRAA RAEEELRKKQ 

       490        500        510        520        530        540 
AYVEKVERLQ QALGQLQAAC EKREQLELRL RTRLEQELKA LRAQQRQAGA PGGSSGSGGS 

       550        560        570        580        590        600 
PELSALRLSE QLREKEEQIL ALEADMTKWE QKYLEERAMR QFAMDAAATA AAQRDTTLIR 

       610        620        630        640        650        660 
HSPQPSPSSS FNEGLLTGGH RHQEMESRLK VLHAQILEKD AVIKVLQQRS RRDPGKAIQG 

       670        680        690        700        710        720 
SLRPAKSVPS VFAAAAAGTQ GWQGLSSSER QTADAPARLT TDRAPTEEPV VTAPPAAHAK 

       730        740        750        760        770 
HGSRDGSTQT DGPPDSTSTC LPPEPDSLLG CSSSQRAASL DSVATSRVQD LSDMVEILI

« Hide

Isoform 2.

Checksum: BD4D8DF260247B01
Show »

FASTA78085,821
Isoform 3.

Checksum: 0A8396140F017544
Show »

FASTA77785,466

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References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 6:63-70(1999) [PubMed: 10231032] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Placenta.
[3]Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Kidney.
[4]"Angiomotin belongs to a novel protein family with conserved coiled-coil and PDZ binding domains."
Bratt A., Wilson W.J., Troyanovsky B., Aase K., Kessler R., Van Meir E.G., Holmgren L.
Gene 298:69-77(2002) [PubMed: 12406577] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 211-779 (ISOFORM 1).
Tissue: Glioblastoma.
[5]Erratum
Bratt A., Wilson W.J., Troyanovsky B., Aase K., Kessler R., Van Meir E.G., Holmgren L.
Gene 310:231-231(2003)
[6]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed: 16641997] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 244-779 (ISOFORM 1), VARIANT GLU-731.
Tissue: Brain.
[8]"Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis."
Wang B., Malik R., Nigg E.A., Korner R.
Anal. Chem. 80:9526-9533(2008) [PubMed: 19007248] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-759, MASS SPECTROMETRY.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB023206 mRNA. Translation: BAA76833.1. Different initiation.
AK291616 mRNA. Translation: BAF84305.1.
AK223598 mRNA. Translation: BAD97318.1. Different initiation.
AF175966 mRNA. Translation: AAD56361.2.
AC010207 Genomic DNA. No translation available.
BC011454 mRNA. Translation: AAH11454.1. Different initiation.
IPIIPI00032236.
IPI00478030.
IPI00942374.
RefSeqNP_057285.3.
UniGeneHs.426312
Hs.713601

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActQ9Y2J4. 10 interactions.
STRINGQ9Y2J4.

PTM databases

PhosphoSiteQ9Y2J4.

Proteomic databases

PRIDEQ9Y2J4.

Genome annotation databases

EnsemblENST00000422605; ENSP00000409999; ENSG00000114019; Homo sapiens. [Genome view]
GeneID51421.
KEGGhsa:51421.
UCSCuc003eqf.1. human.
uc003eqg.1. human.

Organism-specific databases

CTD51421.
GeneCardsGC03M135556.
HGNCHGNC:17812. AMOTL2.
HPACAB003709.
PharmGKBPA24775.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG11220.
HOVERGENQ9Y2J4.
InParanoidQ9Y2J4.

Gene expression databases

BgeeQ9Y2J4.
CleanExHS_AMOTL2.
GenevestigatorQ9Y2J4.
GermOnlineENSG00000114019. Homo sapiens.

Family and domain databases

InterProIPR009114. Angiomotin.
[Graphical view]
PANTHERPTHR14826. Angiomotin. 1 hit.
PRINTSPR01807. ANGIOMOTIN.
ProtoNetSearch...

Other Resources

NextBio54965.

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Entry information

Entry nameAMOL2_HUMAN
AccessionPrimary (citable) accession number: Q9Y2J4
Secondary accession number(s): A8K6F1 expand/collapse secondary AC list , Q53EP1, Q96F99, Q9UKB4
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: September 27, 2005
Last modified: January 19, 2010
This is version 60 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Relevant documents

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

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List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents