Q9Y2J4 (AMOL2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Angiomotin-like protein 2

Alternative name(s):
Leman coiled-coil protein
Short name=LCCP

Gene names

Name:	AMOTL2
Synonyms:	KIAA0989

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	779 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities	Belongs to the angiomotin family.
Sequence caution	The sequence AAH11454.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAA76833.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence BAD97318.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9Y2J4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Y2J4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     701-701: T → TA

Isoform 3 (identifier: Q9Y2J4-3)

The sequence of this isoform differs from the canonical sequence as follows:
     525-526: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 779	779	Angiomotin-like protein 2		PRO_0000190672
Regions
	Coiled coil	308 – 581	274	Potential
	Motif	776 – 779	4	PDZ-binding
Amino acid modifications
	Modified residue	759	1	Phosphoserine Ref.8
Natural variations
	Alternative sequence	525 – 526	2	Missing in isoform 3.		VSP_037826
	Alternative sequence	701	1	T → TA in isoform 2.		VSP_015711
	Natural variant	227	1	T → I. Corresponds to variant rs35377537 [ dbSNP | Ensembl ].		VAR_055497
	Natural variant	342	1	A → P. Corresponds to variant rs2303635 [ dbSNP | Ensembl ].		VAR_055498
	Natural variant	415	1	G → S. Corresponds to variant rs2241559 [ dbSNP | Ensembl ].		VAR_055499
	Natural variant	731	1	E → D. Ref.1 Ref.2 Ref.3 Ref.4 Corresponds to variant rs1353776 [ dbSNP | Ensembl ].		VAR_023535
Experimental info
	Sequence conflict	680	1	Q → K in AAD56361. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 5, 2010. Version 3. Checksum: 665BE69FD7757CEF	FASTA	779	85,764
	10 20 30 40 50 60 MRTLEDSSGT VLHRLIQEQL RYGNLTETRT LLAIQQQALR GGAGTGGTGS PQASLEILAP 70 80 90 100 110 120 EDSQVLQQAT RQEPQGQEHQ GGENHLAENT LYRLCPQPSK GEELPTYEEA KAHSQYYAAQ 130 140 150 160 170 180 QAGTRPHAGD RDPRGAPGGS RRQDEALREL RHGHVRSLSE RLLQLSLERN GARAPSHMSS 190 200 210 220 230 240 SHSFPQLARN QQGPPLRGPP AEGPESRGPP PQYPHVVLAH ETTTAVTDPR YRARGSPHFQ 250 260 270 280 290 300 HAEVRILQAQ VPPVFLQQQQ QYQYLQQSQE HPPPPHPAAL GHGPLSSLSP PAVEGPVSAQ 310 320 330 340 350 360 ASSATSGSAH LAQMEAVLRE NARLQRDNER LQRELESSAE KAGRIEKLES EIQRLSEAHE 370 380 390 400 410 420 SLTRASSKRE ALEKTMRNKM DSEMRRLQDF NRDLRERLES ANRRLASKTQ EAQAGSQDMV 430 440 450 460 470 480 AKLLAQSYEQ QQEQEKLERE MALLRGAIED QRRRAELLEQ ALGNAQGRAA RAEEELRKKQ 490 500 510 520 530 540 AYVEKVERLQ QALGQLQAAC EKREQLELRL RTRLEQELKA LRAQQRQAGA PGGSSGSGGS 550 560 570 580 590 600 PELSALRLSE QLREKEEQIL ALEADMTKWE QKYLEERAMR QFAMDAAATA AAQRDTTLIR 610 620 630 640 650 660 HSPQPSPSSS FNEGLLTGGH RHQEMESRLK VLHAQILEKD AVIKVLQQRS RRDPGKAIQG 670 680 690 700 710 720 SLRPAKSVPS VFAAAAAGTQ GWQGLSSSER QTADAPARLT TDRAPTEEPV VTAPPAAHAK 730 740 750 760 770 HGSRDGSTQT EGPPDSTSTC LPPEPDSLLG CSSSQRAASL DSVATSRVQD LSDMVEILI
	Isoform 2 [UniParc]. Checksum: BC8B569E10247B01	FASTA	780	85,835
	10 20 30 40 50 60 MRTLEDSSGT VLHRLIQEQL RYGNLTETRT LLAIQQQALR GGAGTGGTGS PQASLEILAP 70 80 90 100 110 120 EDSQVLQQAT RQEPQGQEHQ GGENHLAENT LYRLCPQPSK GEELPTYEEA KAHSQYYAAQ 130 140 150 160 170 180 QAGTRPHAGD RDPRGAPGGS RRQDEALREL RHGHVRSLSE RLLQLSLERN GARAPSHMSS 190 200 210 220 230 240 SHSFPQLARN QQGPPLRGPP AEGPESRGPP PQYPHVVLAH ETTTAVTDPR YRARGSPHFQ 250 260 270 280 290 300 HAEVRILQAQ VPPVFLQQQQ QYQYLQQSQE HPPPPHPAAL GHGPLSSLSP PAVEGPVSAQ 310 320 330 340 350 360 ASSATSGSAH LAQMEAVLRE NARLQRDNER LQRELESSAE KAGRIEKLES EIQRLSEAHE 370 380 390 400 410 420 SLTRASSKRE ALEKTMRNKM DSEMRRLQDF NRDLRERLES ANRRLASKTQ EAQAGSQDMV 430 440 450 460 470 480 AKLLAQSYEQ QQEQEKLERE MALLRGAIED QRRRAELLEQ ALGNAQGRAA RAEEELRKKQ 490 500 510 520 530 540 AYVEKVERLQ QALGQLQAAC EKREQLELRL RTRLEQELKA LRAQQRQAGA PGGSSGSGGS 550 560 570 580 590 600 PELSALRLSE QLREKEEQIL ALEADMTKWE QKYLEERAMR QFAMDAAATA AAQRDTTLIR 610 620 630 640 650 660 HSPQPSPSSS FNEGLLTGGH RHQEMESRLK VLHAQILEKD AVIKVLQQRS RRDPGKAIQG 670 680 690 700 710 720 SLRPAKSVPS VFAAAAAGTQ GWQGLSSSER QTADAPARLT TADRAPTEEP VVTAPPAAHA 730 740 750 760 770 780 KHGSRDGSTQ TEGPPDSTST CLPPEPDSLL GCSSSQRAAS LDSVATSRVQ DLSDMVEILI
	Isoform 3 [UniParc]. Checksum: 0B454D787F017544	FASTA	777	85,480
	10 20 30 40 50 60 MRTLEDSSGT VLHRLIQEQL RYGNLTETRT LLAIQQQALR GGAGTGGTGS PQASLEILAP 70 80 90 100 110 120 EDSQVLQQAT RQEPQGQEHQ GGENHLAENT LYRLCPQPSK GEELPTYEEA KAHSQYYAAQ 130 140 150 160 170 180 QAGTRPHAGD RDPRGAPGGS RRQDEALREL RHGHVRSLSE RLLQLSLERN GARAPSHMSS 190 200 210 220 230 240 SHSFPQLARN QQGPPLRGPP AEGPESRGPP PQYPHVVLAH ETTTAVTDPR YRARGSPHFQ 250 260 270 280 290 300 HAEVRILQAQ VPPVFLQQQQ QYQYLQQSQE HPPPPHPAAL GHGPLSSLSP PAVEGPVSAQ 310 320 330 340 350 360 ASSATSGSAH LAQMEAVLRE NARLQRDNER LQRELESSAE KAGRIEKLES EIQRLSEAHE 370 380 390 400 410 420 SLTRASSKRE ALEKTMRNKM DSEMRRLQDF NRDLRERLES ANRRLASKTQ EAQAGSQDMV 430 440 450 460 470 480 AKLLAQSYEQ QQEQEKLERE MALLRGAIED QRRRAELLEQ ALGNAQGRAA RAEEELRKKQ 490 500 510 520 530 540 AYVEKVERLQ QALGQLQAAC EKREQLELRL RTRLEQELKA LRAQQAGAPG GSSGSGGSPE 550 560 570 580 590 600 LSALRLSEQL REKEEQILAL EADMTKWEQK YLEERAMRQF AMDAAATAAA QRDTTLIRHS 610 620 630 640 650 660 PQPSPSSSFN EGLLTGGHRH QEMESRLKVL HAQILEKDAV IKVLQQRSRR DPGKAIQGSL 670 680 690 700 710 720 RPAKSVPSVF AAAAAGTQGW QGLSSSERQT ADAPARLTTD RAPTEEPVVT APPAAHAKHG 730 740 750 760 770 SRDGSTQTEG PPDSTSTCLP PEPDSLLGCS SSQRAASLDS VATSRVQDLS DMVEILI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 6:63-70(1999) [PubMed: 10231032] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ASP-731. Tissue: Brain.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ASP-731. Tissue: Placenta.
[3]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT ASP-731. Tissue: Kidney.
[4]	"Angiomotin belongs to a novel protein family with conserved coiled-coil and PDZ binding domains." Bratt A., Wilson W.J., Troyanovsky B., Aase K., Kessler R., Van Meir E.G., Holmgren L. Gene 298:69-77(2002) [PubMed: 12406577] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 211-779 (ISOFORM 1), VARIANT ASP-731. Tissue: Glioblastoma.
[5]	Erratum Bratt A., Wilson W.J., Troyanovsky B., Aase K., Kessler R., Van Meir E.G., Holmgren L. Gene 310:231-231(2003)
[6]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed: 16641997] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 244-779 (ISOFORM 1). Tissue: Brain.
[8]	"Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis." Wang B., Malik R., Nigg E.A., Korner R. Anal. Chem. 80:9526-9533(2008) [PubMed: 19007248] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-759, MASS SPECTROMETRY. Tissue: Cervix carcinoma.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB023206 mRNA. Translation: BAA76833.1. Different initiation. AK291616 mRNA. Translation: BAF84305.1. AK223598 mRNA. Translation: BAD97318.1. Different initiation. AF175966 mRNA. Translation: AAD56361.2. AC010207 Genomic DNA. No translation available. BC011454 mRNA. Translation: AAH11454.1. Different initiation.
IPI	IPI00032236. IPI00478030. IPI00942374.
RefSeq	NP_057285.3. NM_016201.2.
UniGene	Hs.426312. Hs.713601.
3D structure databases
ProteinModelPortal	Q9Y2J4.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y2J4. 13 interactions.
STRING	Q9Y2J4.
PTM databases
PhosphoSite	Q9Y2J4.
Polymorphism databases
DMDM	308153633.
Proteomic databases
PRIDE	Q9Y2J4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000422605; ENSP00000409999; ENSG00000114019.
GeneID	51421.
KEGG	hsa:51421.
UCSC	uc003eqf.1. human. uc003eqg.1. human.
Organism-specific databases
CTD	51421.
GeneCards	GC03M134074.
H-InvDB	HIX0003700.
HGNC	HGNC:17812. AMOTL2.
HPA	CAB003709.
neXtProt	NX_Q9Y2J4.
PharmGKB	PA24775.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG11220.
GeneTree	ENSGT00530000063846.
HOVERGEN	HBG066485.
InParanoid	Q9Y2J4.
OMA	QEHQGGE.
Gene expression databases
Bgee	Q9Y2J4.
CleanEx	HS_AMOTL2.
Genevestigator	Q9Y2J4.
GermOnline	ENSG00000114019. Homo sapiens.
Family and domain databases
InterPro	IPR009114. Angiomotin. IPR024646. Angiomotin_C. [Graphical view]
PANTHER	PTHR14826. Angiomotin. 1 hit.
Pfam	PF12240. Angiomotin_C. 1 hit. [Graphical view]
PRINTS	PR01807. ANGIOMOTIN.
ProtoNet	Search...
Other
NextBio	54965.

Entry information

Entry name

AMOL2_HUMAN

Accession

Primary (citable) accession number: Q9Y2J4
Secondary accession number(s): A8K6F1 , Q53EP1, Q96F99, Q9UKB4

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2005
Last sequence update:	October 5, 2010
Last modified:	January 25, 2012
This is version 75 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.