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UniProtKB - Q9Y2J4 (AMOL2_HUMAN)

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Protein

Angiomotin-like protein 2

Gene

AMOTL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC.3 Publications

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Biological processWnt signaling pathway

Enzyme and pathway databases

ReactomeiR-HSA-2028269. Signaling by Hippo.

Names & Taxonomyi

Protein namesi
Recommended name:
Angiomotin-like protein 2
Alternative name(s):
Leman coiled-coil protein
Short name:
LCCP
Gene namesi
Name:AMOTL2
Synonyms:KIAA0989
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000114019.14.
HGNCiHGNC:17812. AMOTL2.
MIMi614658. gene.
neXtProtiNX_Q9Y2J4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi51421.
OpenTargetsiENSG00000114019.
PharmGKBiPA24775.

Polymorphism and mutation databases

BioMutaiAMOTL2.
DMDMi308153633.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001906721 – 779Angiomotin-like protein 2Add BLAST779

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei107Phosphotyrosine; by FGFR1By similarity1
Modified residuei759PhosphoserineCombined sources1
Modified residuei762PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylation at Tyr-107 is necessary for efficient binding to SRC and synergistically functioning with SRC to activate the downstream MAPK pathway.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9Y2J4.
PeptideAtlasiQ9Y2J4.
PRIDEiQ9Y2J4.

PTM databases

iPTMnetiQ9Y2J4.
PhosphoSitePlusiQ9Y2J4.

Expressioni

Gene expression databases

BgeeiENSG00000114019.
CleanExiHS_AMOTL2.
ExpressionAtlasiQ9Y2J4. baseline and differential.
GenevisibleiQ9Y2J4. HS.

Organism-specific databases

HPAiHPA063027.

Interactioni

Subunit structurei

Interacts with SRC.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ADY3Q077323EBI-746752,EBI-33406From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
BLZF1Q9H2G93EBI-10187270,EBI-2548012
BRMS1LQ5PSV43EBI-10187270,EBI-5666615
CAF40P538293EBI-746752,EBI-28306From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
CARD9Q9H2575EBI-10187270,EBI-751319
CCHCR1Q8TD31-33EBI-10187270,EBI-10175300
CDC11P324583EBI-746752,EBI-4178From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
CDR2Q018503EBI-10187270,EBI-1181367
CYTH4Q8WWE83EBI-10187270,EBI-10277443
DDIT3P35638-23EBI-10187270,EBI-10173632
DYNLL1P631673EBI-10187270,EBI-349105
DZIP1LQ8IYY44EBI-746752,EBI-10264440
EIF4E2O605733EBI-10187270,EBI-398610
FAM184AQ6P9G83EBI-10187270,EBI-10253239
GNG5P632183EBI-10187270,EBI-10220734
GOLGA2Q083793EBI-10187270,EBI-618309
GSTM5P464393EBI-10187270,EBI-4312072
KRT13A1A4E93EBI-10187270,EBI-10171552
KRT15P190123EBI-10187270,EBI-739566
KRT19P087273EBI-10187270,EBI-742756
KRT20P359003EBI-10187270,EBI-742094
KRT31Q153233EBI-10187270,EBI-948001
KRT38O760153EBI-10187270,EBI-1047263
KRTAP10-5P603703EBI-10187270,EBI-10172150
KRTAP4-2Q9BYR53EBI-10187270,EBI-10172511
LMO4P619683EBI-10187270,EBI-2798728
MAGEA4Q1RN333EBI-10187270,EBI-10194128
MAGOHBQ96A723EBI-746752,EBI-746778
MFAP1P550813EBI-10187270,EBI-1048159
MON1P531293EBI-746752,EBI-23945From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
MPP1Q000133EBI-746752,EBI-711788
MTMR6Q9Y2173EBI-10187270,EBI-766064
MYO5BQ9ULV03EBI-10187270,EBI-311356
NFIL3Q166493EBI-10187270,EBI-3951858
PSMC3P179805EBI-10187270,EBI-359720
RAD51DO757716EBI-746752,EBI-1055693
RALBP1Q153113EBI-10187270,EBI-749285
RASSF5Q8WWW03EBI-10187270,EBI-367390
RNF20Q5VTR24EBI-746752,EBI-2372238
RNF40O751503EBI-10187270,EBI-744408
RPT5P332973EBI-746752,EBI-13920From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
RRD1P404543EBI-746752,EBI-25278From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
SH3RF2Q08AM83EBI-10187270,EBI-10225873
SMARCE1Q969G33EBI-10187270,EBI-455078
SP100P234973EBI-10187270,EBI-751145
SPAG5Q96R063EBI-10187270,EBI-413317
THRAP108273EBI-10187270,EBI-286285
TMCC2O75069-43EBI-10187270,EBI-10177480
TRAF2Q129333EBI-10187270,EBI-355744
TRIM27P143733EBI-10187270,EBI-719493
UBA3Q993443EBI-746752,EBI-37997From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
WDYHV1Q96HA83EBI-10187270,EBI-741158
YDL057WQ073793EBI-746752,EBI-2342994From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
ZBED1O960063EBI-10187270,EBI-740037
ZGPATA0A0S2Z6H03EBI-746752,EBI-16428984
ZGPATQ8N5A53EBI-10187270,EBI-3439227
ZGPATQ8N5A5-23EBI-746752,EBI-10183064

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi119530. 83 interactors.
CORUMiQ9Y2J4.
DIPiDIP-57510N.
IntActiQ9Y2J4. 115 interactors.
MINTiQ9Y2J4.
STRINGi9606.ENSP00000249883.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2J4.
SMRiQ9Y2J4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili308 – 581Sequence analysisAdd BLAST274

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi776 – 779PDZ-binding4

Sequence similaritiesi

Belongs to the angiomotin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEF3. Eukaryota.
ENOG410ZEXZ. LUCA.
GeneTreeiENSGT00530000063846.
HOGENOMiHOG000233789.
HOVERGENiHBG066485.
InParanoidiQ9Y2J4.
KOiK06104.
OMAiRHQEMEN.
OrthoDBiEOG091G07Y9.
PhylomeDBiQ9Y2J4.
TreeFamiTF333368.

Family and domain databases

InterProiView protein in InterPro
IPR009114. Angiomotin.
IPR024646. Angiomotin_C.
PfamiView protein in Pfam
PF12240. Angiomotin_C. 1 hit.
PRINTSiPR01807. ANGIOMOTIN.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y2J4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRTLEDSSGT VLHRLIQEQL RYGNLTETRT LLAIQQQALR GGAGTGGTGS 
        60         70         80         90        100
PQASLEILAP EDSQVLQQAT RQEPQGQEHQ GGENHLAENT LYRLCPQPSK 
       110        120        130        140        150
GEELPTYEEA KAHSQYYAAQ QAGTRPHAGD RDPRGAPGGS RRQDEALREL 
       160        170        180        190        200
RHGHVRSLSE RLLQLSLERN GARAPSHMSS SHSFPQLARN QQGPPLRGPP 
       210        220        230        240        250
AEGPESRGPP PQYPHVVLAH ETTTAVTDPR YRARGSPHFQ HAEVRILQAQ 
       260        270        280        290        300
VPPVFLQQQQ QYQYLQQSQE HPPPPHPAAL GHGPLSSLSP PAVEGPVSAQ 
       310        320        330        340        350
ASSATSGSAH LAQMEAVLRE NARLQRDNER LQRELESSAE KAGRIEKLES 
       360        370        380        390        400
EIQRLSEAHE SLTRASSKRE ALEKTMRNKM DSEMRRLQDF NRDLRERLES 
       410        420        430        440        450
ANRRLASKTQ EAQAGSQDMV AKLLAQSYEQ QQEQEKLERE MALLRGAIED 
       460        470        480        490        500
QRRRAELLEQ ALGNAQGRAA RAEEELRKKQ AYVEKVERLQ QALGQLQAAC 
       510        520        530        540        550
EKREQLELRL RTRLEQELKA LRAQQRQAGA PGGSSGSGGS PELSALRLSE 
       560        570        580        590        600
QLREKEEQIL ALEADMTKWE QKYLEERAMR QFAMDAAATA AAQRDTTLIR 
       610        620        630        640        650
HSPQPSPSSS FNEGLLTGGH RHQEMESRLK VLHAQILEKD AVIKVLQQRS 
       660        670        680        690        700
RRDPGKAIQG SLRPAKSVPS VFAAAAAGTQ GWQGLSSSER QTADAPARLT 
       710        720        730        740        750
TDRAPTEEPV VTAPPAAHAK HGSRDGSTQT EGPPDSTSTC LPPEPDSLLG 
       760        770 
CSSSQRAASL DSVATSRVQD LSDMVEILI
Length:779
Mass (Da):85,764
Last modified:October 5, 2010 - v3
Checksum:i665BE69FD7757CEF
GO
Isoform 2 (identifier: Q9Y2J4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     701-701: T → TA

Show »
Length:780
Mass (Da):85,835
Checksum:iBC8B569E10247B01
GO
Isoform 3 (identifier: Q9Y2J4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     525-526: Missing.

Note: No experimental confirmation available.
Show »
Length:777
Mass (Da):85,480
Checksum:i0B454D787F017544
GO
Isoform 4 (identifier: Q9Y2J4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MTGRKASGGTPCTLRKGAPIITLGKNWTERLAAGDSVGCSGARCHRPLSRQLCASQRSM

Note: No experimental confirmation available.
Show »
Length:837
Mass (Da):91,817
Checksum:i18CC1B88CF34F90A
GO

Sequence cautioni

The sequence AAH11454 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA76833 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAD97318 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti666K → E in BAH12987 (PubMed:14702039).Curated1
Sequence conflicti680Q → K in AAD56361 (PubMed:12406577).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055497227T → I. Corresponds to variant dbSNP:rs35377537Ensembl.1
Natural variantiVAR_055498342A → P. Corresponds to variant dbSNP:rs2303635Ensembl.1
Natural variantiVAR_055499415G → S. Corresponds to variant dbSNP:rs2241559Ensembl.1
Natural variantiVAR_023535731E → D4 PublicationsCorresponds to variant dbSNP:rs1353776Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0440811M → MTGRKASGGTPCTLRKGAPI ITLGKNWTERLAAGDSVGCS GARCHRPLSRQLCASQRSM in isoform 4. 1 Publication1
Alternative sequenceiVSP_037826525 – 526Missing in isoform 3. 1 Publication2
Alternative sequenceiVSP_015711701T → TA in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023206 mRNA. Translation: BAA76833.1. Different initiation.
AK291616 mRNA. Translation: BAF84305.1.
AK299270 mRNA. Translation: BAH12987.1.
AK223598 mRNA. Translation: BAD97318.1. Different initiation.
AF175966 mRNA. Translation: AAD56361.2.
AC010207 Genomic DNA. No translation available.
BC011454 mRNA. Translation: AAH11454.1. Different initiation.
CCDSiCCDS33860.1. [Q9Y2J4-2]
CCDS63783.1. [Q9Y2J4-3]
CCDS63784.1. [Q9Y2J4-4]
RefSeqiNP_001265612.1. NM_001278683.1. [Q9Y2J4-4]
NP_001265614.1. NM_001278685.1. [Q9Y2J4-3]
NP_057285.3. NM_016201.3. [Q9Y2J4-2]
XP_006713717.1. XM_006713654.2. [Q9Y2J4-1]
XP_011511183.1. XM_011512881.1. [Q9Y2J4-1]
XP_016862069.1. XM_017006580.1. [Q9Y2J4-2]
XP_016862070.1. XM_017006581.1. [Q9Y2J4-2]
XP_016862071.1. XM_017006582.1. [Q9Y2J4-2]
UniGeneiHs.426312.
Hs.713601.

Genome annotation databases

EnsembliENST00000249883; ENSP00000249883; ENSG00000114019. [Q9Y2J4-2]
ENST00000422605; ENSP00000409999; ENSG00000114019. [Q9Y2J4-1]
ENST00000513145; ENSP00000425475; ENSG00000114019. [Q9Y2J4-3]
ENST00000514516; ENSP00000424765; ENSG00000114019. [Q9Y2J4-4]
GeneIDi51421.
KEGGihsa:51421.
UCSCiuc003eqf.4. human. [Q9Y2J4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiAMOL2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2J4
Secondary accession number(s): A8K6F1
, B7Z5Q1, E9PHW3, Q53EP1, Q96F99, Q9UKB4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: October 5, 2010
Last modified: March 28, 2018
This is version 136 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome