UniProtKB - Q9Y2J4 (AMOL2_HUMAN)
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Protein
Angiomotin-like protein 2
Gene
AMOTL2
Organism
Homo sapiens (Human)
Status
Functioni
Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC.3 Publications
GO - Molecular functioni
- identical protein binding Source: Ensembl
GO - Biological processi
- hippo signaling Source: Reactome
- Wnt signaling pathway Source: UniProtKB-KW
Keywordsi
Biological process | Wnt signaling pathway |
Enzyme and pathway databases
Reactomei | R-HSA-2028269. Signaling by Hippo. |
Names & Taxonomyi
Protein namesi | Recommended name: Angiomotin-like protein 2Alternative name(s): Leman coiled-coil protein Short name: LCCP |
Gene namesi | Name:AMOTL2 Synonyms:KIAA0989 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000114019.14. |
HGNCi | HGNC:17812. AMOTL2. |
MIMi | 614658. gene. |
neXtProti | NX_Q9Y2J4. |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 51421. |
OpenTargetsi | ENSG00000114019. |
PharmGKBi | PA24775. |
Polymorphism and mutation databases
BioMutai | AMOTL2. |
DMDMi | 308153633. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000190672 | 1 – 779 | Angiomotin-like protein 2Add BLAST | 779 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 107 | Phosphotyrosine; by FGFR1By similarity | 1 | |
Modified residuei | 759 | PhosphoserineCombined sources | 1 | |
Modified residuei | 762 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Phosphorylation at Tyr-107 is necessary for efficient binding to SRC and synergistically functioning with SRC to activate the downstream MAPK pathway.By similarity
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q9Y2J4. |
PeptideAtlasi | Q9Y2J4. |
PRIDEi | Q9Y2J4. |
PTM databases
iPTMneti | Q9Y2J4. |
PhosphoSitePlusi | Q9Y2J4. |
Expressioni
Gene expression databases
Bgeei | ENSG00000114019. |
CleanExi | HS_AMOTL2. |
ExpressionAtlasi | Q9Y2J4. baseline and differential. |
Genevisiblei | Q9Y2J4. HS. |
Organism-specific databases
HPAi | HPA063027. |
Interactioni
Subunit structurei
Interacts with SRC.1 Publication
Binary interactionsi
GO - Molecular functioni
- identical protein binding Source: Ensembl
Protein-protein interaction databases
BioGridi | 119530. 83 interactors. |
CORUMi | Q9Y2J4. |
DIPi | DIP-57510N. |
IntActi | Q9Y2J4. 115 interactors. |
MINTi | Q9Y2J4. |
STRINGi | 9606.ENSP00000249883. |
Structurei
3D structure databases
ProteinModelPortali | Q9Y2J4. |
SMRi | Q9Y2J4. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 308 – 581 | Sequence analysisAdd BLAST | 274 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 776 – 779 | PDZ-binding | 4 |
Sequence similaritiesi
Belongs to the angiomotin family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG410IEF3. Eukaryota. ENOG410ZEXZ. LUCA. |
GeneTreei | ENSGT00530000063846. |
HOGENOMi | HOG000233789. |
HOVERGENi | HBG066485. |
InParanoidi | Q9Y2J4. |
KOi | K06104. |
OMAi | RHQEMEN. |
OrthoDBi | EOG091G07Y9. |
PhylomeDBi | Q9Y2J4. |
TreeFami | TF333368. |
Family and domain databases
InterProi | View protein in InterPro IPR009114. Angiomotin. IPR024646. Angiomotin_C. |
Pfami | View protein in Pfam PF12240. Angiomotin_C. 1 hit. |
PRINTSi | PR01807. ANGIOMOTIN. |
s (4)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9Y2J4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MRTLEDSSGT VLHRLIQEQL RYGNLTETRT LLAIQQQALR GGAGTGGTGS
60 70 80 90 100
PQASLEILAP EDSQVLQQAT RQEPQGQEHQ GGENHLAENT LYRLCPQPSK
110 120 130 140 150
GEELPTYEEA KAHSQYYAAQ QAGTRPHAGD RDPRGAPGGS RRQDEALREL
160 170 180 190 200
RHGHVRSLSE RLLQLSLERN GARAPSHMSS SHSFPQLARN QQGPPLRGPP
210 220 230 240 250
AEGPESRGPP PQYPHVVLAH ETTTAVTDPR YRARGSPHFQ HAEVRILQAQ
260 270 280 290 300
VPPVFLQQQQ QYQYLQQSQE HPPPPHPAAL GHGPLSSLSP PAVEGPVSAQ
310 320 330 340 350
ASSATSGSAH LAQMEAVLRE NARLQRDNER LQRELESSAE KAGRIEKLES
360 370 380 390 400
EIQRLSEAHE SLTRASSKRE ALEKTMRNKM DSEMRRLQDF NRDLRERLES
410 420 430 440 450
ANRRLASKTQ EAQAGSQDMV AKLLAQSYEQ QQEQEKLERE MALLRGAIED
460 470 480 490 500
QRRRAELLEQ ALGNAQGRAA RAEEELRKKQ AYVEKVERLQ QALGQLQAAC
510 520 530 540 550
EKREQLELRL RTRLEQELKA LRAQQRQAGA PGGSSGSGGS PELSALRLSE
560 570 580 590 600
QLREKEEQIL ALEADMTKWE QKYLEERAMR QFAMDAAATA AAQRDTTLIR
610 620 630 640 650
HSPQPSPSSS FNEGLLTGGH RHQEMESRLK VLHAQILEKD AVIKVLQQRS
660 670 680 690 700
RRDPGKAIQG SLRPAKSVPS VFAAAAAGTQ GWQGLSSSER QTADAPARLT
710 720 730 740 750
TDRAPTEEPV VTAPPAAHAK HGSRDGSTQT EGPPDSTSTC LPPEPDSLLG
760 770
CSSSQRAASL DSVATSRVQD LSDMVEILI
Sequence cautioni
The sequence AAH11454 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA76833 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAD97318 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 666 | K → E in BAH12987 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 680 | Q → K in AAD56361 (PubMed:12406577).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_055497 | 227 | T → I. Corresponds to variant dbSNP:rs35377537Ensembl. | 1 | |
Natural variantiVAR_055498 | 342 | A → P. Corresponds to variant dbSNP:rs2303635Ensembl. | 1 | |
Natural variantiVAR_055499 | 415 | G → S. Corresponds to variant dbSNP:rs2241559Ensembl. | 1 | |
Natural variantiVAR_023535 | 731 | E → D4 PublicationsCorresponds to variant dbSNP:rs1353776Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_044081 | 1 | M → MTGRKASGGTPCTLRKGAPI ITLGKNWTERLAAGDSVGCS GARCHRPLSRQLCASQRSM in isoform 4. 1 Publication | 1 | |
Alternative sequenceiVSP_037826 | 525 – 526 | Missing in isoform 3. 1 Publication | 2 | |
Alternative sequenceiVSP_015711 | 701 | T → TA in isoform 2. 2 Publications | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB023206 mRNA. Translation: BAA76833.1. Different initiation. AK291616 mRNA. Translation: BAF84305.1. AK299270 mRNA. Translation: BAH12987.1. AK223598 mRNA. Translation: BAD97318.1. Different initiation. AF175966 mRNA. Translation: AAD56361.2. AC010207 Genomic DNA. No translation available. BC011454 mRNA. Translation: AAH11454.1. Different initiation. |
CCDSi | CCDS33860.1. [Q9Y2J4-2] CCDS63783.1. [Q9Y2J4-3] CCDS63784.1. [Q9Y2J4-4] |
RefSeqi | NP_001265612.1. NM_001278683.1. [Q9Y2J4-4] NP_001265614.1. NM_001278685.1. [Q9Y2J4-3] NP_057285.3. NM_016201.3. [Q9Y2J4-2] XP_006713717.1. XM_006713654.2. [Q9Y2J4-1] XP_011511183.1. XM_011512881.1. [Q9Y2J4-1] XP_016862069.1. XM_017006580.1. [Q9Y2J4-2] XP_016862070.1. XM_017006581.1. [Q9Y2J4-2] XP_016862071.1. XM_017006582.1. [Q9Y2J4-2] |
UniGenei | Hs.426312. Hs.713601. |
Genome annotation databases
Ensembli | ENST00000249883; ENSP00000249883; ENSG00000114019. [Q9Y2J4-2] ENST00000422605; ENSP00000409999; ENSG00000114019. [Q9Y2J4-1] ENST00000513145; ENSP00000425475; ENSG00000114019. [Q9Y2J4-3] ENST00000514516; ENSP00000424765; ENSG00000114019. [Q9Y2J4-4] |
GeneIDi | 51421. |
KEGGi | hsa:51421. |
UCSCi | uc003eqf.4. human. [Q9Y2J4-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Entry informationi
Entry namei | AMOL2_HUMAN | |
Accessioni | Q9Y2J4Primary (citable) accession number: Q9Y2J4 Secondary accession number(s): A8K6F1 Q9UKB4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 27, 2005 |
Last sequence update: | October 5, 2010 | |
Last modified: | March 28, 2018 | |
This is version 136 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |