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Protein

Band 4.1-like protein 3

Gene

EPB41L3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5.4 Publications

GO - Molecular functioni

  • actin binding Source: UniProtKB-KW
  • structural constituent of cytoskeleton Source: BHF-UCL

GO - Biological processi

Keywordsi

Molecular functionActin-binding
Biological processApoptosis

Enzyme and pathway databases

ReactomeiR-HSA-6794361 Neurexins and neuroligins
SIGNORiQ9Y2J2

Names & Taxonomyi

Protein namesi
Recommended name:
Band 4.1-like protein 3
Alternative name(s):
4.1B
Differentially expressed in adenocarcinoma of the lung protein 1
Short name:
DAL-1
Cleaved into the following chain:
Gene namesi
Name:EPB41L3
Synonyms:DAL1, KIAA0987
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000082397.16
HGNCiHGNC:3380 EPB41L3
MIMi605331 gene
neXtProtiNX_Q9Y2J2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNETi23136
OpenTargetsiENSG00000082397
PharmGKBiPA27813

Polymorphism and mutation databases

BioMutaiEPB41L3
DMDMi17433099

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002193991 – 1087Band 4.1-like protein 3Add BLAST1087
Initiator methionineiRemoved; alternateCombined sources
ChainiPRO_00004231942 – 1087Band 4.1-like protein 3, N-terminally processedAdd BLAST1086

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei2N-acetylthreonine; in Band 4.1-like protein 3, N-terminally processedCombined sources1
Modified residuei88PhosphoserineBy similarity1
Modified residuei420PhosphoserineCombined sources1
Modified residuei443PhosphoserineBy similarity1
Modified residuei460PhosphoserineCombined sources1
Modified residuei469PhosphothreonineCombined sources1
Modified residuei492PhosphothreonineBy similarity1
Modified residuei706PhosphothreonineBy similarity1
Modified residuei708PhosphoserineBy similarity1
Modified residuei960PhosphoserineBy similarity1
Modified residuei962PhosphoserineCombined sources1
Modified residuei1081PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9Y2J2
PaxDbiQ9Y2J2
PeptideAtlasiQ9Y2J2
PRIDEiQ9Y2J2

PTM databases

iPTMnetiQ9Y2J2
PhosphoSitePlusiQ9Y2J2

Expressioni

Tissue specificityi

Expressed at high levels in brain, with lower levels in kidney, intestine, and testis. Detected in lung.1 Publication

Gene expression databases

BgeeiENSG00000082397
CleanExiHS_EPB41L3
ExpressionAtlasiQ9Y2J2 baseline and differential
GenevisibleiQ9Y2J2 HS

Organism-specific databases

HPAiHPA028605

Interactioni

Subunit structurei

Interacts (via FERM domain) with CADM1. Interacts with PRMT3, PRMT5 and PRMT6.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TCF4P158843EBI-10326138,EBI-533224

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116753, 103 interactors
CORUMiQ9Y2J2
DIPiDIP-17035N
IntActiQ9Y2J2, 93 interactors
MINTiQ9Y2J2
STRINGi9606.ENSP00000341138

Structurei

Secondary structure

11087
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi109 – 115Combined sources7
Beta strandi121 – 127Combined sources7
Helixi132 – 142Combined sources11
Helixi148 – 150Combined sources3
Beta strandi151 – 156Combined sources6
Beta strandi162 – 164Combined sources3
Helixi171 – 174Combined sources4
Beta strandi180 – 188Combined sources9
Helixi193 – 195Combined sources3
Helixi199 – 214Combined sources16
Helixi222 – 237Combined sources16
Turni242 – 244Combined sources3
Turni247 – 252Combined sources6
Beta strandi256 – 258Combined sources3
Helixi261 – 273Combined sources13
Turni274 – 276Combined sources3
Helixi279 – 290Combined sources12
Turni294 – 297Combined sources4
Beta strandi299 – 304Combined sources6
Beta strandi310 – 315Combined sources6
Beta strandi317 – 324Combined sources8
Beta strandi327 – 333Combined sources7
Helixi334 – 336Combined sources3
Beta strandi339 – 343Combined sources5
Beta strandi346 – 351Combined sources6
Turni354 – 357Combined sources4
Beta strandi361 – 366Combined sources6
Helixi370 – 388Combined sources19

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HE7X-ray2.00A108-390[»]
3BINX-ray2.30A109-390[»]
ProteinModelPortaliQ9Y2J2
SMRiQ9Y2J2
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y2J2

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini110 – 391FERMPROSITE-ProRule annotationAdd BLAST282

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni394 – 513HydrophilicAdd BLAST120
Regioni514 – 860Spectrin--actin-bindingSequence analysisAdd BLAST347
Regioni861 – 1083C-terminal (CTD)Add BLAST223

Phylogenomic databases

eggNOGiKOG3527 Eukaryota
ENOG410Y7NQ LUCA
GeneTreeiENSGT00760000118823
HOGENOMiHOG000228840
HOVERGENiHBG007777
InParanoidiQ9Y2J2
KOiK06107
OMAiITNEWEK
OrthoDBiEOG091G00IL
PhylomeDBiQ9Y2J2
TreeFamiTF351626

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
Gene3Di1.20.80.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR030691 Band4.1-L3
IPR008379 Band_4.1_C
IPR019749 Band_41_domain
IPR000798 Ez/rad/moesin-like
IPR014847 FERM-adjacent
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR019747 FERM_CS
IPR000299 FERM_domain
IPR018979 FERM_N
IPR018980 FERM_PH-like_C
IPR011993 PH-like_dom_sf
IPR007477 SAB_dom
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR23280:SF20 PTHR23280:SF20, 1 hit
PfamiView protein in Pfam
PF05902 4_1_CTD, 1 hit
PF08736 FA, 1 hit
PF09380 FERM_C, 1 hit
PF00373 FERM_M, 1 hit
PF09379 FERM_N, 1 hit
PF04382 SAB, 1 hit
PRINTSiPR00935 BAND41
PR00661 ERMFAMILY
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM01195 FA, 1 hit
SM01196 FERM_C, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS00660 FERM_1, 1 hit
PS00661 FERM_2, 1 hit
PS50057 FERM_3, 1 hit

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: Q9Y2J2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTTESGSDSE SKPDQEAEPQ EAAGAQGRAG APVPEPPKEE QQQALEQFAA
60 70 80 90 100
AAAHSTPVRR EVTDKEQEFA ARAAKQLEYQ QLEDDKLSQK SSSSKLSRSP
110 120 130 140 150
LKIVKKPKSM QCKVILLDGS EYTCDVEKRS RGQVLFDKVC EHLNLLEKDY
160 170 180 190 200
FGLTYRDAEN QKNWLDPAKE IKKQVRSGAW HFSFNVKFYP PDPAQLSEDI
210 220 230 240 250
TRYYLCLQLR DDIVSGRLPC SFVTLALLGS YTVQSELGDY DPDECGSDYI
260 270 280 290 300
SEFRFAPNHT KELEDKVIEL HKSHRGMTPA EAEMHFLENA KKLSMYGVDL
310 320 330 340 350
HHAKDSEGVE IMLGVCASGL LIYRDRLRIN RFAWPKVLKI SYKRNNFYIK
360 370 380 390 400
IRPGEFEQFE STIGFKLPNH RAAKRLWKVC VEHHTFFRLL LPEAPPKKFL
410 420 430 440 450
TLGSKFRYSG RTQAQTRRAS ALIDRPAPYF ERSSSKRYTM SRSLDGEVGT
460 470 480 490 500
GQYATTKGIS QTNLITTVTP EKKAEEERDE EEDKRRKGEE VTPISAIRHE
510 520 530 540 550
GKSPGLGTDS CPLSPPSTHC APTSPTELRR RCKENDCKLP GYEPSRAEHL
560 570 580 590 600
PGEPALDSDG PGRPYLGDQD VAFSYRQQTG KGTTLFSFSL QLPESFPSLL
610 620 630 640 650
DDDGYLSFPN LSETNLLPQS LQHYLPIRSP SLVPCFLFIF FFLLSASFSV
660 670 680 690 700
PYALTLSFPL ALCLCYLEPK AASLSASLDN DPSDSSEEET DSERTDTAAD
710 720 730 740 750
GETTATESDQ EEDAELKAQE LEKTQDDLMK HQTNISELKR TFLETSTDTA
760 770 780 790 800
VTNEWEKRLS TSPVRLAARQ EDAPMIEPLV PEETKQSSGE KLMDGSEIFS
810 820 830 840 850
LLESARKPTE FIGGVTSTSQ SWVQKMETKT ESSGIETEPT VHHLPLSTEK
860 870 880 890 900
VVQETVLVEE RRVVHASGDA SYSAGDSGDA AAQPAFTGIK GKEGSALTEG
910 920 930 940 950
AKEEGGEEVA KAVLEQEETA AASRERQEEQ SAAIHISETL EQKPHFESST
960 970 980 990 1000
VKTETISFGS VSPGGVKLEI STKEVPVVHT ETKTITYESS QVDPGTDLEP
1010 1020 1030 1040 1050
GVLMSAQTIT SETTSTTTTT HITKTVKGGI SETRIEKRIV ITGDADIDHD
1060 1070 1080
QALAQAIKEA KEQHPDMSVT KVVVHKETEI TPEDGED
Length:1,087
Mass (Da):120,678
Last modified:December 5, 2001 - v2
Checksum:i0A33CA4A43F12620
GO
Isoform 2 (identifier: Q9Y2J2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     446-446: G → GASVNENHEIYMKDSMSAA
     503-689: Missing.
     708-719: Missing.
     784-824: Missing.

Show »
Length:865
Mass (Da):96,514
Checksum:iC2070B01BF7F9422
GO
Isoform 3 (identifier: Q9Y2J2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     446-446: G → GASVNENHEIYMKDSMSAA
     503-689: Missing.
     708-719: Missing.
     784-824: Missing.
     835-1087: Missing.

Show »
Length:612
Mass (Da):69,521
Checksum:i3881FB17E0DBAD00
GO
Isoform 4 (identifier: Q9Y2J2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     446-446: G → GASVNENHEIYMKDSMSAA
     503-689: Missing.
     1052-1052: A → E
     1053-1087: Missing.

Show »
Length:883
Mass (Da):98,461
Checksum:iE25FB2E14F6745D3
GO

Sequence cautioni

The sequence AAC79806 differs from that shown. Reason: Frameshift at positions 29 and 59.Curated
The sequence BAA76831 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12K → E in BAH12571 (PubMed:14702039).Curated1
Sequence conflicti32Missing in AAC79806 (PubMed:9892180).Curated1
Sequence conflicti498R → Q in AAC79806 (PubMed:9892180).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048353555A → T. Corresponds to variant dbSNP:rs9966357Ensembl.1
Natural variantiVAR_048354575Y → C. Corresponds to variant dbSNP:rs8082898Ensembl.1
Natural variantiVAR_048355859E → Q. Corresponds to variant dbSNP:rs8096452Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_000482446G → GASVNENHEIYMKDSMSAA in isoform 2, isoform 3 and isoform 4. 3 Publications1
Alternative sequenceiVSP_000483503 – 689Missing in isoform 2, isoform 3 and isoform 4. 3 PublicationsAdd BLAST187
Alternative sequenceiVSP_000484708 – 719Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST12
Alternative sequenceiVSP_000485784 – 824Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST41
Alternative sequenceiVSP_000486835 – 1087Missing in isoform 3. 1 PublicationAdd BLAST253
Alternative sequenceiVSP_0548191052A → E in isoform 4. 1 Publication1
Alternative sequenceiVSP_0548201053 – 1087Missing in isoform 4. 1 PublicationAdd BLAST35

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069072 mRNA Translation: AAC79806.1 Frameshift.
AB023204 mRNA Translation: BAA76831.1 Different initiation.
AK297406 mRNA Translation: BAH12571.1
AP001032 Genomic DNA No translation available.
AP005059 Genomic DNA No translation available.
AP005671 Genomic DNA No translation available.
BC006141 mRNA Translation: AAH06141.1
CCDSiCCDS11838.1 [Q9Y2J2-1]
CCDS62381.1 [Q9Y2J2-2]
CCDS62382.1 [Q9Y2J2-4]
RefSeqiNP_001268462.1, NM_001281533.1 [Q9Y2J2-4]
NP_001268463.1, NM_001281534.1 [Q9Y2J2-2]
NP_001268464.1, NM_001281535.1
NP_036439.2, NM_012307.3 [Q9Y2J2-1]
XP_016881125.1, XM_017025636.1 [Q9Y2J2-4]
UniGeneiHs.213394

Genome annotation databases

EnsembliENST00000341928; ENSP00000343158; ENSG00000082397 [Q9Y2J2-1]
ENST00000540638; ENSP00000442091; ENSG00000082397 [Q9Y2J2-2]
ENST00000544123; ENSP00000441174; ENSG00000082397 [Q9Y2J2-4]
GeneIDi23136
KEGGihsa:23136
UCSCiuc002kmt.3 human [Q9Y2J2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiE41L3_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2J2
Secondary accession number(s): B7Z4I5
, F5GX05, O95713, Q9BRP5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: December 5, 2001
Last modified: May 23, 2018
This is version 173 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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