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Protein

Band 4.1-like protein 3

Gene

EPB41L3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5.4 Publications

GO - Molecular functioni

  • structural constituent of cytoskeleton Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000082397-MONOMER.
ReactomeiR-HSA-6794361. Interactions of neurexins and neuroligins at synapses.

Names & Taxonomyi

Protein namesi
Recommended name:
Band 4.1-like protein 3
Alternative name(s):
4.1B
Differentially expressed in adenocarcinoma of the lung protein 1
Short name:
DAL-1
Cleaved into the following chain:
Gene namesi
Name:EPB41L3
Synonyms:DAL1, KIAA0987
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:3380. EPB41L3.

Subcellular locationi

  • Cytoplasmcytoskeleton By similarity
  • Cell junction 1 Publication
  • Cell membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication
  • Cytoplasm 1 Publication

  • Note: Detected in the cytoplasm of actively dividing cells.

GO - Cellular componenti

  • axolemma Source: Ensembl
  • cell-cell junction Source: HGNC
  • cytoplasm Source: UniProtKB-SubCell
  • cytoskeleton Source: GO_Central
  • extrinsic component of membrane Source: InterPro
  • juxtaparanode region of axon Source: BHF-UCL
  • paranode region of axon Source: BHF-UCL
  • plasma membrane Source: UniProtKB
  • postsynaptic density Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNETi23136.
OpenTargetsiENSG00000082397.
PharmGKBiPA27813.

Polymorphism and mutation databases

BioMutaiEPB41L3.
DMDMi17433099.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002193991 – 1087Band 4.1-like protein 3Add BLAST1087
Initiator methionineiRemoved; alternateCombined sources
ChainiPRO_00004231942 – 1087Band 4.1-like protein 3, N-terminally processedAdd BLAST1086

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei2N-acetylthreonine; in Band 4.1-like protein 3, N-terminally processedCombined sources1
Modified residuei88PhosphoserineBy similarity1
Modified residuei420PhosphoserineCombined sources1
Modified residuei443PhosphoserineBy similarity1
Modified residuei460PhosphoserineCombined sources1
Modified residuei469PhosphothreonineCombined sources1
Modified residuei492PhosphothreonineBy similarity1
Modified residuei706PhosphothreonineBy similarity1
Modified residuei708PhosphoserineBy similarity1
Modified residuei960PhosphoserineBy similarity1
Modified residuei962PhosphoserineCombined sources1
Modified residuei1081PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9Y2J2.
PaxDbiQ9Y2J2.
PeptideAtlasiQ9Y2J2.
PRIDEiQ9Y2J2.

PTM databases

iPTMnetiQ9Y2J2.
PhosphoSitePlusiQ9Y2J2.

Expressioni

Tissue specificityi

Expressed at high levels in brain, with lower levels in kidney, intestine, and testis. Detected in lung.1 Publication

Gene expression databases

BgeeiENSG00000082397.
CleanExiHS_EPB41L3.
ExpressionAtlasiQ9Y2J2. baseline and differential.
GenevisibleiQ9Y2J2. HS.

Organism-specific databases

HPAiHPA028605.

Interactioni

Subunit structurei

Interacts (via FERM domain) with CADM1. Interacts with PRMT3, PRMT5 and PRMT6.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TCF4P158843EBI-10326138,EBI-533224

Protein-protein interaction databases

BioGridi116753. 100 interactors.
DIPiDIP-17035N.
IntActiQ9Y2J2. 91 interactors.
MINTiMINT-1630957.
STRINGi9606.ENSP00000341138.

Structurei

Secondary structure

11087
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi109 – 115Combined sources7
Beta strandi121 – 127Combined sources7
Helixi132 – 142Combined sources11
Helixi148 – 150Combined sources3
Beta strandi151 – 156Combined sources6
Beta strandi162 – 164Combined sources3
Helixi171 – 174Combined sources4
Beta strandi180 – 188Combined sources9
Helixi193 – 195Combined sources3
Helixi199 – 214Combined sources16
Helixi222 – 237Combined sources16
Turni242 – 244Combined sources3
Turni247 – 252Combined sources6
Beta strandi256 – 258Combined sources3
Helixi261 – 273Combined sources13
Turni274 – 276Combined sources3
Helixi279 – 290Combined sources12
Turni294 – 297Combined sources4
Beta strandi299 – 304Combined sources6
Beta strandi310 – 315Combined sources6
Beta strandi317 – 324Combined sources8
Beta strandi327 – 333Combined sources7
Helixi334 – 336Combined sources3
Beta strandi339 – 343Combined sources5
Beta strandi346 – 351Combined sources6
Turni354 – 357Combined sources4
Beta strandi361 – 366Combined sources6
Helixi370 – 388Combined sources19

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HE7X-ray2.00A108-390[»]
3BINX-ray2.30A109-390[»]
ProteinModelPortaliQ9Y2J2.
SMRiQ9Y2J2.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y2J2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini110 – 391FERMPROSITE-ProRule annotationAdd BLAST282

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni394 – 513HydrophilicAdd BLAST120
Regioni514 – 860Spectrin--actin-bindingSequence analysisAdd BLAST347
Regioni861 – 1083C-terminal (CTD)Add BLAST223

Sequence similaritiesi

Contains 1 FERM domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3527. Eukaryota.
ENOG410Y7NQ. LUCA.
GeneTreeiENSGT00760000118823.
HOGENOMiHOG000228840.
HOVERGENiHBG007777.
InParanoidiQ9Y2J2.
KOiK06107.
OMAiAITNEWE.
OrthoDBiEOG091G00IL.
PhylomeDBiQ9Y2J2.
TreeFamiTF351626.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR030691. Band4.1-L3.
IPR008379. Band_4.1_C.
IPR019749. Band_41_domain.
IPR000798. Ez/rad/moesin-like.
IPR014847. FERM-adjacent.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR011993. PH_dom-like.
IPR007477. SAB_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR23280:SF20. PTHR23280:SF20. 2 hits.
PfamiPF05902. 4_1_CTD. 1 hit.
PF08736. FA. 1 hit.
PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF04382. SAB. 1 hit.
[Graphical view]
PRINTSiPR00935. BAND41.
PR00661. ERMFAMILY.
SMARTiSM00295. B41. 1 hit.
SM01195. FA. 1 hit.
SM01196. FERM_C. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: Q9Y2J2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTTESGSDSE SKPDQEAEPQ EAAGAQGRAG APVPEPPKEE QQQALEQFAA
60 70 80 90 100
AAAHSTPVRR EVTDKEQEFA ARAAKQLEYQ QLEDDKLSQK SSSSKLSRSP
110 120 130 140 150
LKIVKKPKSM QCKVILLDGS EYTCDVEKRS RGQVLFDKVC EHLNLLEKDY
160 170 180 190 200
FGLTYRDAEN QKNWLDPAKE IKKQVRSGAW HFSFNVKFYP PDPAQLSEDI
210 220 230 240 250
TRYYLCLQLR DDIVSGRLPC SFVTLALLGS YTVQSELGDY DPDECGSDYI
260 270 280 290 300
SEFRFAPNHT KELEDKVIEL HKSHRGMTPA EAEMHFLENA KKLSMYGVDL
310 320 330 340 350
HHAKDSEGVE IMLGVCASGL LIYRDRLRIN RFAWPKVLKI SYKRNNFYIK
360 370 380 390 400
IRPGEFEQFE STIGFKLPNH RAAKRLWKVC VEHHTFFRLL LPEAPPKKFL
410 420 430 440 450
TLGSKFRYSG RTQAQTRRAS ALIDRPAPYF ERSSSKRYTM SRSLDGEVGT
460 470 480 490 500
GQYATTKGIS QTNLITTVTP EKKAEEERDE EEDKRRKGEE VTPISAIRHE
510 520 530 540 550
GKSPGLGTDS CPLSPPSTHC APTSPTELRR RCKENDCKLP GYEPSRAEHL
560 570 580 590 600
PGEPALDSDG PGRPYLGDQD VAFSYRQQTG KGTTLFSFSL QLPESFPSLL
610 620 630 640 650
DDDGYLSFPN LSETNLLPQS LQHYLPIRSP SLVPCFLFIF FFLLSASFSV
660 670 680 690 700
PYALTLSFPL ALCLCYLEPK AASLSASLDN DPSDSSEEET DSERTDTAAD
710 720 730 740 750
GETTATESDQ EEDAELKAQE LEKTQDDLMK HQTNISELKR TFLETSTDTA
760 770 780 790 800
VTNEWEKRLS TSPVRLAARQ EDAPMIEPLV PEETKQSSGE KLMDGSEIFS
810 820 830 840 850
LLESARKPTE FIGGVTSTSQ SWVQKMETKT ESSGIETEPT VHHLPLSTEK
860 870 880 890 900
VVQETVLVEE RRVVHASGDA SYSAGDSGDA AAQPAFTGIK GKEGSALTEG
910 920 930 940 950
AKEEGGEEVA KAVLEQEETA AASRERQEEQ SAAIHISETL EQKPHFESST
960 970 980 990 1000
VKTETISFGS VSPGGVKLEI STKEVPVVHT ETKTITYESS QVDPGTDLEP
1010 1020 1030 1040 1050
GVLMSAQTIT SETTSTTTTT HITKTVKGGI SETRIEKRIV ITGDADIDHD
1060 1070 1080
QALAQAIKEA KEQHPDMSVT KVVVHKETEI TPEDGED
Length:1,087
Mass (Da):120,678
Last modified:December 5, 2001 - v2
Checksum:i0A33CA4A43F12620
GO
Isoform 2 (identifier: Q9Y2J2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     446-446: G → GASVNENHEIYMKDSMSAA
     503-689: Missing.
     708-719: Missing.
     784-824: Missing.

Show »
Length:865
Mass (Da):96,514
Checksum:iC2070B01BF7F9422
GO
Isoform 3 (identifier: Q9Y2J2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     446-446: G → GASVNENHEIYMKDSMSAA
     503-689: Missing.
     708-719: Missing.
     784-824: Missing.
     835-1087: Missing.

Show »
Length:612
Mass (Da):69,521
Checksum:i3881FB17E0DBAD00
GO
Isoform 4 (identifier: Q9Y2J2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     446-446: G → GASVNENHEIYMKDSMSAA
     503-689: Missing.
     1052-1052: A → E
     1053-1087: Missing.

Show »
Length:883
Mass (Da):98,461
Checksum:iE25FB2E14F6745D3
GO

Sequence cautioni

The sequence AAC79806 differs from that shown. Reason: Frameshift at positions 29 and 59.Curated
The sequence BAA76831 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12K → E in BAH12571 (PubMed:14702039).Curated1
Sequence conflicti32Missing in AAC79806 (PubMed:9892180).Curated1
Sequence conflicti498R → Q in AAC79806 (PubMed:9892180).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048353555A → T.Corresponds to variant rs9966357dbSNPEnsembl.1
Natural variantiVAR_048354575Y → C.Corresponds to variant rs8082898dbSNPEnsembl.1
Natural variantiVAR_048355859E → Q.Corresponds to variant rs8096452dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_000482446G → GASVNENHEIYMKDSMSAA in isoform 2, isoform 3 and isoform 4. 3 Publications1
Alternative sequenceiVSP_000483503 – 689Missing in isoform 2, isoform 3 and isoform 4. 3 PublicationsAdd BLAST187
Alternative sequenceiVSP_000484708 – 719Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST12
Alternative sequenceiVSP_000485784 – 824Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST41
Alternative sequenceiVSP_000486835 – 1087Missing in isoform 3. 1 PublicationAdd BLAST253
Alternative sequenceiVSP_0548191052A → E in isoform 4. 1 Publication1
Alternative sequenceiVSP_0548201053 – 1087Missing in isoform 4. 1 PublicationAdd BLAST35

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069072 mRNA. Translation: AAC79806.1. Frameshift.
AB023204 mRNA. Translation: BAA76831.1. Different initiation.
AK297406 mRNA. Translation: BAH12571.1.
AP001032 Genomic DNA. No translation available.
AP005059 Genomic DNA. No translation available.
AP005671 Genomic DNA. No translation available.
BC006141 mRNA. Translation: AAH06141.1.
CCDSiCCDS11838.1. [Q9Y2J2-1]
CCDS62381.1. [Q9Y2J2-2]
CCDS62382.1. [Q9Y2J2-4]
RefSeqiNP_001268462.1. NM_001281533.1. [Q9Y2J2-4]
NP_001268463.1. NM_001281534.1. [Q9Y2J2-2]
NP_001268464.1. NM_001281535.1.
NP_036439.2. NM_012307.3. [Q9Y2J2-1]
XP_016881125.1. XM_017025636.1. [Q9Y2J2-4]
UniGeneiHs.213394.

Genome annotation databases

EnsembliENST00000341928; ENSP00000343158; ENSG00000082397. [Q9Y2J2-1]
ENST00000540638; ENSP00000442091; ENSG00000082397. [Q9Y2J2-2]
ENST00000544123; ENSP00000441174; ENSG00000082397. [Q9Y2J2-4]
GeneIDi23136.
KEGGihsa:23136.
UCSCiuc002kmt.3. human. [Q9Y2J2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069072 mRNA. Translation: AAC79806.1. Frameshift.
AB023204 mRNA. Translation: BAA76831.1. Different initiation.
AK297406 mRNA. Translation: BAH12571.1.
AP001032 Genomic DNA. No translation available.
AP005059 Genomic DNA. No translation available.
AP005671 Genomic DNA. No translation available.
BC006141 mRNA. Translation: AAH06141.1.
CCDSiCCDS11838.1. [Q9Y2J2-1]
CCDS62381.1. [Q9Y2J2-2]
CCDS62382.1. [Q9Y2J2-4]
RefSeqiNP_001268462.1. NM_001281533.1. [Q9Y2J2-4]
NP_001268463.1. NM_001281534.1. [Q9Y2J2-2]
NP_001268464.1. NM_001281535.1.
NP_036439.2. NM_012307.3. [Q9Y2J2-1]
XP_016881125.1. XM_017025636.1. [Q9Y2J2-4]
UniGeneiHs.213394.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HE7X-ray2.00A108-390[»]
3BINX-ray2.30A109-390[»]
ProteinModelPortaliQ9Y2J2.
SMRiQ9Y2J2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116753. 100 interactors.
DIPiDIP-17035N.
IntActiQ9Y2J2. 91 interactors.
MINTiMINT-1630957.
STRINGi9606.ENSP00000341138.

PTM databases

iPTMnetiQ9Y2J2.
PhosphoSitePlusiQ9Y2J2.

Polymorphism and mutation databases

BioMutaiEPB41L3.
DMDMi17433099.

Proteomic databases

EPDiQ9Y2J2.
PaxDbiQ9Y2J2.
PeptideAtlasiQ9Y2J2.
PRIDEiQ9Y2J2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341928; ENSP00000343158; ENSG00000082397. [Q9Y2J2-1]
ENST00000540638; ENSP00000442091; ENSG00000082397. [Q9Y2J2-2]
ENST00000544123; ENSP00000441174; ENSG00000082397. [Q9Y2J2-4]
GeneIDi23136.
KEGGihsa:23136.
UCSCiuc002kmt.3. human. [Q9Y2J2-1]

Organism-specific databases

CTDi23136.
DisGeNETi23136.
GeneCardsiEPB41L3.
HGNCiHGNC:3380. EPB41L3.
HPAiHPA028605.
MIMi605331. gene.
neXtProtiNX_Q9Y2J2.
OpenTargetsiENSG00000082397.
PharmGKBiPA27813.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3527. Eukaryota.
ENOG410Y7NQ. LUCA.
GeneTreeiENSGT00760000118823.
HOGENOMiHOG000228840.
HOVERGENiHBG007777.
InParanoidiQ9Y2J2.
KOiK06107.
OMAiAITNEWE.
OrthoDBiEOG091G00IL.
PhylomeDBiQ9Y2J2.
TreeFamiTF351626.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000082397-MONOMER.
ReactomeiR-HSA-6794361. Interactions of neurexins and neuroligins at synapses.

Miscellaneous databases

ChiTaRSiEPB41L3. human.
EvolutionaryTraceiQ9Y2J2.
GeneWikiiEPB41L3.
GenomeRNAii23136.
PROiQ9Y2J2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000082397.
CleanExiHS_EPB41L3.
ExpressionAtlasiQ9Y2J2. baseline and differential.
GenevisibleiQ9Y2J2. HS.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR030691. Band4.1-L3.
IPR008379. Band_4.1_C.
IPR019749. Band_41_domain.
IPR000798. Ez/rad/moesin-like.
IPR014847. FERM-adjacent.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR011993. PH_dom-like.
IPR007477. SAB_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR23280:SF20. PTHR23280:SF20. 2 hits.
PfamiPF05902. 4_1_CTD. 1 hit.
PF08736. FA. 1 hit.
PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF04382. SAB. 1 hit.
[Graphical view]
PRINTSiPR00935. BAND41.
PR00661. ERMFAMILY.
SMARTiSM00295. B41. 1 hit.
SM01195. FA. 1 hit.
SM01196. FERM_C. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiE41L3_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2J2
Secondary accession number(s): B7Z4I5
, F5GX05, O95713, Q9BRP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: December 5, 2001
Last modified: November 30, 2016
This is version 159 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.