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Q9Y2I8 (WDR37_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
WD repeat-containing protein 37
Gene names
Name:WDR37
Synonyms:KIAA0982
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length494 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 7 WD repeats.

Sequence caution

The sequence BAA76826.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   DomainRepeat
WD repeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 494494WD repeat-containing protein 37
PRO_0000051387

Regions

Repeat154 – 19441WD 1
Repeat197 – 23640WD 2
Repeat279 – 31840WD 3
Repeat321 – 36040WD 4
Repeat365 – 40339WD 5
Repeat406 – 44540WD 6
Repeat452 – 49342WD 7

Natural variations

Natural variant2251I → V.
Corresponds to variant rs2306407 [ dbSNP | Ensembl ].
VAR_025432

Experimental info

Sequence conflict2671C → S in BAA76826. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9Y2I8 [UniParc].

Last modified March 7, 2006. Version 2.
Checksum: 49D05A24DD230005

FASTA49454,665
        10         20         30         40         50         60 
MPTESASCST ARQTKQKRKS HSLSIRRTNS SEQERTGLPR DMLEGQDSKL PSSVRSTLLE 

        70         80         90        100        110        120 
LFGQIEREFE NLYIENLELR REIDTLNERL AAEGQAIDGA ELSKGQLKTK ASHSTSQLSQ 

       130        140        150        160        170        180 
KLKTTYKAST SKIVSSFKTT TSRAACQLVK EYIGHRDGIW DVSVAKTQPV VLGTASADHT 

       190        200        210        220        230        240 
ALLWSIETGK CLVKYAGHVG SVNSIKFHPS EQLALTASGD QTAHIWRYAV QLPTPQPVAD 

       250        260        270        280        290        300 
TSISGEDEVE CSDKDEPDLD GDVSSDCPTI RVPLTSLKSH QGVVIASDWL VGGKQAVTAS 

       310        320        330        340        350        360 
WDRTANLYDV ETSELVHSLT GHDQELTHCC THPTQRLVVT SSRDTTFRLW DFRDPSIHSV 

       370        380        390        400        410        420 
NVFQGHTDTV TSAVFTVGDN VVSGSDDRTV KVWDLKNMRS PIATIRTDSA INRINVCVGQ 

       430        440        450        460        470        480 
KIIALPHDNR QVRLFDMSGV RLARLPRSSR QGHRRMVCCS AWSEDHPVCN LFTCGFDRQA 

       490 
IGWNINIPAL LQEK

« Hide

References

[1]"Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 6:63-70(1999) [PubMed: 10231032] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[2]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed: 11230166] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[3]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed: 15164054] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB023199 mRNA. Translation: BAA76826.2. Different initiation.
AL136827 mRNA. Translation: CAB66761.1.
AL607085, AC022536 Genomic DNA. Translation: CAI15166.1.
CH471072 Genomic DNA. Translation: EAW86514.1.
CH471072 Genomic DNA. Translation: EAW86516.1.
IPIIPI00032202.
PIRT46442.
RefSeqNP_054742.2. NM_014023.3.
UniGeneHs.188495.

3D structure databases

ProteinModelPortalQ9Y2I8.
SMRQ9Y2I8. Positions 146-492.
ModBaseSearch...

Protein-protein interaction databases

MINTMINT-3976528.
STRINGQ9Y2I8.

PTM databases

PhosphoSiteQ9Y2I8.

Polymorphism databases

DMDM90122397.

Proteomic databases

PRIDEQ9Y2I8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000263150; ENSP00000263150; ENSG00000047056.
ENST00000358220; ENSP00000350954; ENSG00000047056.
GeneID22884.
KEGGhsa:22884.
UCSCuc001igf.1. human.

Organism-specific databases

CTD22884.
GeneCardsGC10P001095.
H-InvDBHIX0008589.
HGNCHGNC:31406. WDR37.
HPAHPA037376.
HPA037565.
neXtProtNX_Q9Y2I8.
PharmGKBPA134922218.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG10288.
GeneTreeENSGT00600000084420.
HOVERGENHBG057072.
InParanoidQ9Y2I8.
OrthoDBEOG4DZ1V5.
PhylomeDBQ9Y2I8.

Gene expression databases

ArrayExpressQ9Y2I8.
BgeeQ9Y2I8.
CleanExHS_WDR37.
GenevestigatorQ9Y2I8.
GermOnlineENSG00000047056. Homo sapiens.

Family and domain databases

InterProIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR011046. WD40_repeat-like_dom.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
Gene3DG3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
PfamPF00400. WD40. 6 hits.
[Graphical view]
PRINTSPR00320. GPROTEINBRPT.
SMARTSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMSSF50978. WD40_like. 1 hit.
PROSITEPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio43471.

Entry information

Entry nameWDR37_HUMAN
AccessionPrimary (citable) accession number: Q9Y2I8
Secondary accession number(s): D3DRQ7, Q5SW03, Q9NTJ6
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 7, 2006
Last modified: January 25, 2012
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents