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Protein

WD repeat-containing protein 37

Gene

WDR37

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000047056-MONOMER.
SignaLinkiQ9Y2I8.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 37
Gene namesi
Name:WDR37
Synonyms:KIAA0982
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:31406. WDR37.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi22884.
OpenTargetsiENSG00000047056.
PharmGKBiPA134922218.

Polymorphism and mutation databases

BioMutaiWDR37.
DMDMi90122397.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000513871 – 494WD repeat-containing protein 37Add BLAST494

Proteomic databases

EPDiQ9Y2I8.
PaxDbiQ9Y2I8.
PeptideAtlasiQ9Y2I8.
PRIDEiQ9Y2I8.

PTM databases

iPTMnetiQ9Y2I8.
PhosphoSitePlusiQ9Y2I8.
SwissPalmiQ9Y2I8.

Expressioni

Gene expression databases

BgeeiENSG00000047056.
CleanExiHS_WDR37.
ExpressionAtlasiQ9Y2I8. baseline and differential.
GenevisibleiQ9Y2I8. HS.

Organism-specific databases

HPAiHPA037376.
HPA037565.

Interactioni

Protein-protein interaction databases

BioGridi116551. 20 interactors.
IntActiQ9Y2I8. 3 interactors.
MINTiMINT-3976528.
STRINGi9606.ENSP00000263150.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2I8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati154 – 194WD 1Add BLAST41
Repeati197 – 236WD 2Add BLAST40
Repeati279 – 318WD 3Add BLAST40
Repeati321 – 360WD 4Add BLAST40
Repeati365 – 403WD 5Add BLAST39
Repeati406 – 445WD 6Add BLAST40
Repeati452 – 493WD 7Add BLAST42

Sequence similaritiesi

Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0300. Eukaryota.
ENOG410XSES. LUCA.
GeneTreeiENSGT00780000121967.
HOGENOMiHOG000013185.
HOVERGENiHBG057072.
InParanoidiQ9Y2I8.
OMAiWDFREAI.
OrthoDBiEOG091G06KJ.
PhylomeDBiQ9Y2I8.
TreeFamiTF105876.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y2I8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPTESASCST ARQTKQKRKS HSLSIRRTNS SEQERTGLPR DMLEGQDSKL
60 70 80 90 100
PSSVRSTLLE LFGQIEREFE NLYIENLELR REIDTLNERL AAEGQAIDGA
110 120 130 140 150
ELSKGQLKTK ASHSTSQLSQ KLKTTYKAST SKIVSSFKTT TSRAACQLVK
160 170 180 190 200
EYIGHRDGIW DVSVAKTQPV VLGTASADHT ALLWSIETGK CLVKYAGHVG
210 220 230 240 250
SVNSIKFHPS EQLALTASGD QTAHIWRYAV QLPTPQPVAD TSISGEDEVE
260 270 280 290 300
CSDKDEPDLD GDVSSDCPTI RVPLTSLKSH QGVVIASDWL VGGKQAVTAS
310 320 330 340 350
WDRTANLYDV ETSELVHSLT GHDQELTHCC THPTQRLVVT SSRDTTFRLW
360 370 380 390 400
DFRDPSIHSV NVFQGHTDTV TSAVFTVGDN VVSGSDDRTV KVWDLKNMRS
410 420 430 440 450
PIATIRTDSA INRINVCVGQ KIIALPHDNR QVRLFDMSGV RLARLPRSSR
460 470 480 490
QGHRRMVCCS AWSEDHPVCN LFTCGFDRQA IGWNINIPAL LQEK
Length:494
Mass (Da):54,665
Last modified:March 7, 2006 - v2
Checksum:i49D05A24DD230005
GO
Isoform 2 (identifier: Q9Y2I8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     242-242: S → SQ

Note: No experimental confirmation available.
Show »
Length:495
Mass (Da):54,794
Checksum:i83408AD0846E3C7A
GO
Isoform 3 (identifier: Q9Y2I8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     243-264: ISGEDEVECSDKDEPDLDGDVS → VSTFPYLRMCRMLMSANLRIHL
     265-494: Missing.

Note: No experimental confirmation available.
Show »
Length:264
Mass (Da):29,265
Checksum:i3193048FA2098A50
GO

Sequence cautioni

The sequence BAA76826 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti267C → S in BAA76826 (PubMed:10231032).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07080511A → T.1 PublicationCorresponds to variant rs17856557dbSNPEnsembl.1
Natural variantiVAR_070806221Q → K.1 PublicationCorresponds to variant rs17856556dbSNPEnsembl.1
Natural variantiVAR_025432225I → V.Corresponds to variant rs2306407dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_054011242S → SQ in isoform 2. 1 Publication1
Alternative sequenceiVSP_054012243 – 264ISGED…DGDVS → VSTFPYLRMCRMLMSANLRI HL in isoform 3. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_054013265 – 494Missing in isoform 3. 1 PublicationAdd BLAST230

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023199 mRNA. Translation: BAA76826.2. Different initiation.
AL136827 mRNA. Translation: CAB66761.1.
AK292591 mRNA. Translation: BAF85280.1.
AL607085, AC022536 Genomic DNA. Translation: CAI15166.1.
CH471072 Genomic DNA. Translation: EAW86514.1.
CH471072 Genomic DNA. Translation: EAW86516.1.
BC018044 mRNA. Translation: AAH18044.1.
CCDSiCCDS7057.1. [Q9Y2I8-1]
PIRiT46442.
RefSeqiNP_054742.2. NM_014023.3. [Q9Y2I8-1]
UniGeneiHs.188495.

Genome annotation databases

EnsembliENST00000263150; ENSP00000263150; ENSG00000047056. [Q9Y2I8-1]
ENST00000358220; ENSP00000350954; ENSG00000047056. [Q9Y2I8-1]
GeneIDi22884.
KEGGihsa:22884.
UCSCiuc001igf.2. human. [Q9Y2I8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023199 mRNA. Translation: BAA76826.2. Different initiation.
AL136827 mRNA. Translation: CAB66761.1.
AK292591 mRNA. Translation: BAF85280.1.
AL607085, AC022536 Genomic DNA. Translation: CAI15166.1.
CH471072 Genomic DNA. Translation: EAW86514.1.
CH471072 Genomic DNA. Translation: EAW86516.1.
BC018044 mRNA. Translation: AAH18044.1.
CCDSiCCDS7057.1. [Q9Y2I8-1]
PIRiT46442.
RefSeqiNP_054742.2. NM_014023.3. [Q9Y2I8-1]
UniGeneiHs.188495.

3D structure databases

ProteinModelPortaliQ9Y2I8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116551. 20 interactors.
IntActiQ9Y2I8. 3 interactors.
MINTiMINT-3976528.
STRINGi9606.ENSP00000263150.

PTM databases

iPTMnetiQ9Y2I8.
PhosphoSitePlusiQ9Y2I8.
SwissPalmiQ9Y2I8.

Polymorphism and mutation databases

BioMutaiWDR37.
DMDMi90122397.

Proteomic databases

EPDiQ9Y2I8.
PaxDbiQ9Y2I8.
PeptideAtlasiQ9Y2I8.
PRIDEiQ9Y2I8.

Protocols and materials databases

DNASUi22884.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263150; ENSP00000263150; ENSG00000047056. [Q9Y2I8-1]
ENST00000358220; ENSP00000350954; ENSG00000047056. [Q9Y2I8-1]
GeneIDi22884.
KEGGihsa:22884.
UCSCiuc001igf.2. human. [Q9Y2I8-1]

Organism-specific databases

CTDi22884.
DisGeNETi22884.
GeneCardsiWDR37.
H-InvDBHIX0190517.
HGNCiHGNC:31406. WDR37.
HPAiHPA037376.
HPA037565.
neXtProtiNX_Q9Y2I8.
OpenTargetsiENSG00000047056.
PharmGKBiPA134922218.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0300. Eukaryota.
ENOG410XSES. LUCA.
GeneTreeiENSGT00780000121967.
HOGENOMiHOG000013185.
HOVERGENiHBG057072.
InParanoidiQ9Y2I8.
OMAiWDFREAI.
OrthoDBiEOG091G06KJ.
PhylomeDBiQ9Y2I8.
TreeFamiTF105876.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000047056-MONOMER.
SignaLinkiQ9Y2I8.

Miscellaneous databases

ChiTaRSiWDR37. human.
GeneWikiiWDR37.
GenomeRNAii22884.
PROiQ9Y2I8.

Gene expression databases

BgeeiENSG00000047056.
CleanExiHS_WDR37.
ExpressionAtlasiQ9Y2I8. baseline and differential.
GenevisibleiQ9Y2I8. HS.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWDR37_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2I8
Secondary accession number(s): A8K976
, D3DRQ7, Q5SW03, Q8WVG2, Q9NTJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 7, 2006
Last modified: November 30, 2016
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.