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Q9Y2I8

- WDR37_HUMAN

UniProt

Q9Y2I8 - WDR37_HUMAN

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Protein

WD repeat-containing protein 37

Gene

WDR37

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

SignaLinkiQ9Y2I8.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 37
Gene namesi
Name:WDR37
Synonyms:KIAA0982
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:31406. WDR37.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134922218.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 494494WD repeat-containing protein 37PRO_0000051387Add
BLAST

Proteomic databases

MaxQBiQ9Y2I8.
PaxDbiQ9Y2I8.
PRIDEiQ9Y2I8.

PTM databases

PhosphoSiteiQ9Y2I8.

Expressioni

Gene expression databases

BgeeiQ9Y2I8.
CleanExiHS_WDR37.
ExpressionAtlasiQ9Y2I8. baseline and differential.
GenevestigatoriQ9Y2I8.

Organism-specific databases

HPAiHPA037376.
HPA037565.

Interactioni

Protein-protein interaction databases

BioGridi116551. 14 interactions.
IntActiQ9Y2I8. 2 interactions.
MINTiMINT-3976528.
STRINGi9606.ENSP00000263150.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2I8.
SMRiQ9Y2I8. Positions 107-486.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati154 – 19441WD 1Add
BLAST
Repeati197 – 23640WD 2Add
BLAST
Repeati279 – 31840WD 3Add
BLAST
Repeati321 – 36040WD 4Add
BLAST
Repeati365 – 40339WD 5Add
BLAST
Repeati406 – 44540WD 6Add
BLAST
Repeati452 – 49342WD 7Add
BLAST

Sequence similaritiesi

Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00640000091456.
HOGENOMiHOG000013185.
HOVERGENiHBG057072.
InParanoidiQ9Y2I8.
OMAiTGLPRDM.
OrthoDBiEOG77DJ5K.
PhylomeDBiQ9Y2I8.
TreeFamiTF105876.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 5 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9Y2I8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPTESASCST ARQTKQKRKS HSLSIRRTNS SEQERTGLPR DMLEGQDSKL
60 70 80 90 100
PSSVRSTLLE LFGQIEREFE NLYIENLELR REIDTLNERL AAEGQAIDGA
110 120 130 140 150
ELSKGQLKTK ASHSTSQLSQ KLKTTYKAST SKIVSSFKTT TSRAACQLVK
160 170 180 190 200
EYIGHRDGIW DVSVAKTQPV VLGTASADHT ALLWSIETGK CLVKYAGHVG
210 220 230 240 250
SVNSIKFHPS EQLALTASGD QTAHIWRYAV QLPTPQPVAD TSISGEDEVE
260 270 280 290 300
CSDKDEPDLD GDVSSDCPTI RVPLTSLKSH QGVVIASDWL VGGKQAVTAS
310 320 330 340 350
WDRTANLYDV ETSELVHSLT GHDQELTHCC THPTQRLVVT SSRDTTFRLW
360 370 380 390 400
DFRDPSIHSV NVFQGHTDTV TSAVFTVGDN VVSGSDDRTV KVWDLKNMRS
410 420 430 440 450
PIATIRTDSA INRINVCVGQ KIIALPHDNR QVRLFDMSGV RLARLPRSSR
460 470 480 490
QGHRRMVCCS AWSEDHPVCN LFTCGFDRQA IGWNINIPAL LQEK
Length:494
Mass (Da):54,665
Last modified:March 7, 2006 - v2
Checksum:i49D05A24DD230005
GO
Isoform 2 (identifier: Q9Y2I8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     242-242: S → SQ

Note: No experimental confirmation available.

Show »
Length:495
Mass (Da):54,794
Checksum:i83408AD0846E3C7A
GO
Isoform 3 (identifier: Q9Y2I8-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     243-264: ISGEDEVECSDKDEPDLDGDVS → VSTFPYLRMCRMLMSANLRIHL
     265-494: Missing.

Note: No experimental confirmation available.

Show »
Length:264
Mass (Da):29,265
Checksum:i3193048FA2098A50
GO

Sequence cautioni

The sequence BAA76826.2 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti267 – 2671C → S in BAA76826. (PubMed:10231032)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti11 – 111A → T.1 Publication
Corresponds to variant rs17856557 [ dbSNP | Ensembl ].
VAR_070805
Natural varianti221 – 2211Q → K.1 Publication
Corresponds to variant rs17856556 [ dbSNP | Ensembl ].
VAR_070806
Natural varianti225 – 2251I → V.
Corresponds to variant rs2306407 [ dbSNP | Ensembl ].
VAR_025432

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei242 – 2421S → SQ in isoform 2. 1 PublicationVSP_054011
Alternative sequencei243 – 26422ISGED…DGDVS → VSTFPYLRMCRMLMSANLRI HL in isoform 3. 1 PublicationVSP_054012Add
BLAST
Alternative sequencei265 – 494230Missing in isoform 3. 1 PublicationVSP_054013Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB023199 mRNA. Translation: BAA76826.2. Different initiation.
AL136827 mRNA. Translation: CAB66761.1.
AK292591 mRNA. Translation: BAF85280.1.
AL607085, AC022536 Genomic DNA. Translation: CAI15166.1.
CH471072 Genomic DNA. Translation: EAW86514.1.
CH471072 Genomic DNA. Translation: EAW86516.1.
BC018044 mRNA. Translation: AAH18044.1.
CCDSiCCDS7057.1. [Q9Y2I8-1]
PIRiT46442.
RefSeqiNP_054742.2. NM_014023.3. [Q9Y2I8-1]
UniGeneiHs.188495.

Genome annotation databases

EnsembliENST00000263150; ENSP00000263150; ENSG00000047056. [Q9Y2I8-1]
ENST00000358220; ENSP00000350954; ENSG00000047056. [Q9Y2I8-1]
GeneIDi22884.
KEGGihsa:22884.
UCSCiuc001igf.1. human. [Q9Y2I8-1]

Polymorphism databases

DMDMi90122397.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB023199 mRNA. Translation: BAA76826.2 . Different initiation.
AL136827 mRNA. Translation: CAB66761.1 .
AK292591 mRNA. Translation: BAF85280.1 .
AL607085 , AC022536 Genomic DNA. Translation: CAI15166.1 .
CH471072 Genomic DNA. Translation: EAW86514.1 .
CH471072 Genomic DNA. Translation: EAW86516.1 .
BC018044 mRNA. Translation: AAH18044.1 .
CCDSi CCDS7057.1. [Q9Y2I8-1 ]
PIRi T46442.
RefSeqi NP_054742.2. NM_014023.3. [Q9Y2I8-1 ]
UniGenei Hs.188495.

3D structure databases

ProteinModelPortali Q9Y2I8.
SMRi Q9Y2I8. Positions 107-486.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116551. 14 interactions.
IntActi Q9Y2I8. 2 interactions.
MINTi MINT-3976528.
STRINGi 9606.ENSP00000263150.

PTM databases

PhosphoSitei Q9Y2I8.

Polymorphism databases

DMDMi 90122397.

Proteomic databases

MaxQBi Q9Y2I8.
PaxDbi Q9Y2I8.
PRIDEi Q9Y2I8.

Protocols and materials databases

DNASUi 22884.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000263150 ; ENSP00000263150 ; ENSG00000047056 . [Q9Y2I8-1 ]
ENST00000358220 ; ENSP00000350954 ; ENSG00000047056 . [Q9Y2I8-1 ]
GeneIDi 22884.
KEGGi hsa:22884.
UCSCi uc001igf.1. human. [Q9Y2I8-1 ]

Organism-specific databases

CTDi 22884.
GeneCardsi GC10P001095.
H-InvDB HIX0190517.
HGNCi HGNC:31406. WDR37.
HPAi HPA037376.
HPA037565.
neXtProti NX_Q9Y2I8.
PharmGKBi PA134922218.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2319.
GeneTreei ENSGT00640000091456.
HOGENOMi HOG000013185.
HOVERGENi HBG057072.
InParanoidi Q9Y2I8.
OMAi TGLPRDM.
OrthoDBi EOG77DJ5K.
PhylomeDBi Q9Y2I8.
TreeFami TF105876.

Enzyme and pathway databases

SignaLinki Q9Y2I8.

Miscellaneous databases

ChiTaRSi WDR37. human.
GeneWikii WDR37.
GenomeRNAii 22884.
NextBioi 35464620.
PROi Q9Y2I8.

Gene expression databases

Bgeei Q9Y2I8.
CleanExi HS_WDR37.
ExpressionAtlasi Q9Y2I8. baseline and differential.
Genevestigatori Q9Y2I8.

Family and domain databases

Gene3Di 2.130.10.10. 2 hits.
InterProi IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00400. WD40. 5 hits.
[Graphical view ]
PRINTSi PR00320. GPROTEINBRPT.
SMARTi SM00320. WD40. 6 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 2 hits.
PROSITEi PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  4. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANTS THR-11 AND LYS-221.
    Tissue: Brain.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiWDR37_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2I8
Secondary accession number(s): A8K976
, D3DRQ7, Q5SW03, Q8WVG2, Q9NTJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 7, 2006
Last modified: October 29, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3