Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9Y2I8

- WDR37_HUMAN

UniProt

Q9Y2I8 - WDR37_HUMAN

Protein

WD repeat-containing protein 37

Gene

WDR37

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 2 (07 Mar 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Enzyme and pathway databases

    SignaLinkiQ9Y2I8.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    WD repeat-containing protein 37
    Gene namesi
    Name:WDR37
    Synonyms:KIAA0982
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:31406. WDR37.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134922218.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 494494WD repeat-containing protein 37PRO_0000051387Add
    BLAST

    Proteomic databases

    MaxQBiQ9Y2I8.
    PaxDbiQ9Y2I8.
    PRIDEiQ9Y2I8.

    PTM databases

    PhosphoSiteiQ9Y2I8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Y2I8.
    BgeeiQ9Y2I8.
    CleanExiHS_WDR37.
    GenevestigatoriQ9Y2I8.

    Organism-specific databases

    HPAiHPA037376.
    HPA037565.

    Interactioni

    Protein-protein interaction databases

    BioGridi116551. 2 interactions.
    IntActiQ9Y2I8. 2 interactions.
    MINTiMINT-3976528.
    STRINGi9606.ENSP00000263150.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y2I8.
    SMRiQ9Y2I8. Positions 147-486.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati154 – 19441WD 1Add
    BLAST
    Repeati197 – 23640WD 2Add
    BLAST
    Repeati279 – 31840WD 3Add
    BLAST
    Repeati321 – 36040WD 4Add
    BLAST
    Repeati365 – 40339WD 5Add
    BLAST
    Repeati406 – 44540WD 6Add
    BLAST
    Repeati452 – 49342WD 7Add
    BLAST

    Sequence similaritiesi

    Contains 7 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiCOG2319.
    HOGENOMiHOG000013185.
    HOVERGENiHBG057072.
    InParanoidiQ9Y2I8.
    OMAiTGLPRDM.
    OrthoDBiEOG77DJ5K.
    PhylomeDBiQ9Y2I8.
    TreeFamiTF105876.

    Family and domain databases

    Gene3Di2.130.10.10. 2 hits.
    InterProiIPR020472. G-protein_beta_WD-40_rep.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF00400. WD40. 5 hits.
    [Graphical view]
    PRINTSiPR00320. GPROTEINBRPT.
    SMARTiSM00320. WD40. 6 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 2 hits.
    PROSITEiPS00678. WD_REPEATS_1. 2 hits.
    PS50082. WD_REPEATS_2. 5 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y2I8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPTESASCST ARQTKQKRKS HSLSIRRTNS SEQERTGLPR DMLEGQDSKL    50
    PSSVRSTLLE LFGQIEREFE NLYIENLELR REIDTLNERL AAEGQAIDGA 100
    ELSKGQLKTK ASHSTSQLSQ KLKTTYKAST SKIVSSFKTT TSRAACQLVK 150
    EYIGHRDGIW DVSVAKTQPV VLGTASADHT ALLWSIETGK CLVKYAGHVG 200
    SVNSIKFHPS EQLALTASGD QTAHIWRYAV QLPTPQPVAD TSISGEDEVE 250
    CSDKDEPDLD GDVSSDCPTI RVPLTSLKSH QGVVIASDWL VGGKQAVTAS 300
    WDRTANLYDV ETSELVHSLT GHDQELTHCC THPTQRLVVT SSRDTTFRLW 350
    DFRDPSIHSV NVFQGHTDTV TSAVFTVGDN VVSGSDDRTV KVWDLKNMRS 400
    PIATIRTDSA INRINVCVGQ KIIALPHDNR QVRLFDMSGV RLARLPRSSR 450
    QGHRRMVCCS AWSEDHPVCN LFTCGFDRQA IGWNINIPAL LQEK 494
    Length:494
    Mass (Da):54,665
    Last modified:March 7, 2006 - v2
    Checksum:i49D05A24DD230005
    GO
    Isoform 2 (identifier: Q9Y2I8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         242-242: S → SQ

    Note: No experimental confirmation available.

    Show »
    Length:495
    Mass (Da):54,794
    Checksum:i83408AD0846E3C7A
    GO
    Isoform 3 (identifier: Q9Y2I8-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         243-264: ISGEDEVECSDKDEPDLDGDVS → VSTFPYLRMCRMLMSANLRIHL
         265-494: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:264
    Mass (Da):29,265
    Checksum:i3193048FA2098A50
    GO

    Sequence cautioni

    The sequence BAA76826.2 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti267 – 2671C → S in BAA76826. (PubMed:10231032)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti11 – 111A → T.1 Publication
    Corresponds to variant rs17856557 [ dbSNP | Ensembl ].
    VAR_070805
    Natural varianti221 – 2211Q → K.1 Publication
    Corresponds to variant rs17856556 [ dbSNP | Ensembl ].
    VAR_070806
    Natural varianti225 – 2251I → V.
    Corresponds to variant rs2306407 [ dbSNP | Ensembl ].
    VAR_025432

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei242 – 2421S → SQ in isoform 2. 1 PublicationVSP_054011
    Alternative sequencei243 – 26422ISGED…DGDVS → VSTFPYLRMCRMLMSANLRI HL in isoform 3. 1 PublicationVSP_054012Add
    BLAST
    Alternative sequencei265 – 494230Missing in isoform 3. 1 PublicationVSP_054013Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB023199 mRNA. Translation: BAA76826.2. Different initiation.
    AL136827 mRNA. Translation: CAB66761.1.
    AK292591 mRNA. Translation: BAF85280.1.
    AL607085, AC022536 Genomic DNA. Translation: CAI15166.1.
    CH471072 Genomic DNA. Translation: EAW86514.1.
    CH471072 Genomic DNA. Translation: EAW86516.1.
    BC018044 mRNA. Translation: AAH18044.1.
    CCDSiCCDS7057.1. [Q9Y2I8-1]
    PIRiT46442.
    RefSeqiNP_054742.2. NM_014023.3. [Q9Y2I8-1]
    UniGeneiHs.188495.

    Genome annotation databases

    EnsembliENST00000263150; ENSP00000263150; ENSG00000047056. [Q9Y2I8-1]
    ENST00000358220; ENSP00000350954; ENSG00000047056. [Q9Y2I8-1]
    GeneIDi22884.
    KEGGihsa:22884.
    UCSCiuc001igf.1. human. [Q9Y2I8-1]

    Polymorphism databases

    DMDMi90122397.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB023199 mRNA. Translation: BAA76826.2 . Different initiation.
    AL136827 mRNA. Translation: CAB66761.1 .
    AK292591 mRNA. Translation: BAF85280.1 .
    AL607085 , AC022536 Genomic DNA. Translation: CAI15166.1 .
    CH471072 Genomic DNA. Translation: EAW86514.1 .
    CH471072 Genomic DNA. Translation: EAW86516.1 .
    BC018044 mRNA. Translation: AAH18044.1 .
    CCDSi CCDS7057.1. [Q9Y2I8-1 ]
    PIRi T46442.
    RefSeqi NP_054742.2. NM_014023.3. [Q9Y2I8-1 ]
    UniGenei Hs.188495.

    3D structure databases

    ProteinModelPortali Q9Y2I8.
    SMRi Q9Y2I8. Positions 147-486.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116551. 2 interactions.
    IntActi Q9Y2I8. 2 interactions.
    MINTi MINT-3976528.
    STRINGi 9606.ENSP00000263150.

    PTM databases

    PhosphoSitei Q9Y2I8.

    Polymorphism databases

    DMDMi 90122397.

    Proteomic databases

    MaxQBi Q9Y2I8.
    PaxDbi Q9Y2I8.
    PRIDEi Q9Y2I8.

    Protocols and materials databases

    DNASUi 22884.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000263150 ; ENSP00000263150 ; ENSG00000047056 . [Q9Y2I8-1 ]
    ENST00000358220 ; ENSP00000350954 ; ENSG00000047056 . [Q9Y2I8-1 ]
    GeneIDi 22884.
    KEGGi hsa:22884.
    UCSCi uc001igf.1. human. [Q9Y2I8-1 ]

    Organism-specific databases

    CTDi 22884.
    GeneCardsi GC10P001095.
    H-InvDB HIX0190517.
    HGNCi HGNC:31406. WDR37.
    HPAi HPA037376.
    HPA037565.
    neXtProti NX_Q9Y2I8.
    PharmGKBi PA134922218.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2319.
    HOGENOMi HOG000013185.
    HOVERGENi HBG057072.
    InParanoidi Q9Y2I8.
    OMAi TGLPRDM.
    OrthoDBi EOG77DJ5K.
    PhylomeDBi Q9Y2I8.
    TreeFami TF105876.

    Enzyme and pathway databases

    SignaLinki Q9Y2I8.

    Miscellaneous databases

    ChiTaRSi WDR37. human.
    GeneWikii WDR37.
    GenomeRNAii 22884.
    NextBioi 35464620.
    PROi Q9Y2I8.

    Gene expression databases

    ArrayExpressi Q9Y2I8.
    Bgeei Q9Y2I8.
    CleanExi HS_WDR37.
    Genevestigatori Q9Y2I8.

    Family and domain databases

    Gene3Di 2.130.10.10. 2 hits.
    InterProi IPR020472. G-protein_beta_WD-40_rep.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF00400. WD40. 5 hits.
    [Graphical view ]
    PRINTSi PR00320. GPROTEINBRPT.
    SMARTi SM00320. WD40. 6 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 2 hits.
    PROSITEi PS00678. WD_REPEATS_1. 2 hits.
    PS50082. WD_REPEATS_2. 5 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Testis.
    4. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANTS THR-11 AND LYS-221.
      Tissue: Brain.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiWDR37_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y2I8
    Secondary accession number(s): A8K976
    , D3DRQ7, Q5SW03, Q8WVG2, Q9NTJ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3