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Protein

1-phosphatidylinositol 3-phosphate 5-kinase

Gene

PIKFYVE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes.1 Publication

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri158 – 218FYVE-typePROSITE-ProRule annotationAdd BLAST61

GO - Molecular functioni

GO - Biological processi

  • intracellular signal transduction Source: Ensembl
  • myelin assembly Source: Ensembl
  • phosphatidylinositol 5-phosphate metabolic process Source: ParkinsonsUK-UCL
  • phosphatidylinositol biosynthetic process Source: Reactome
  • protein localization to nucleus Source: UniProtKB
  • regulation of autophagosome assembly Source: ParkinsonsUK-UCL
  • retrograde transport, endosome to Golgi Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciMetaCyc:HS03825-MONOMER.
ZFISH:HS03825-MONOMER.
BRENDAi2.7.1.150. 2681.
2.7.1.68. 2681.
ReactomeiR-HSA-1660514. Synthesis of PIPs at the Golgi membrane.
R-HSA-1660516. Synthesis of PIPs at the early endosome membrane.
R-HSA-1660517. Synthesis of PIPs at the late endosome membrane.
SIGNORiQ9Y2I7.

Names & Taxonomyi

Protein namesi
Recommended name:
1-phosphatidylinositol 3-phosphate 5-kinase (EC:2.7.1.150)
Short name:
Phosphatidylinositol 3-phosphate 5-kinase
Alternative name(s):
FYVE finger-containing phosphoinositide kinase
PIKfyve
Phosphatidylinositol 3-phosphate 5-kinase type III
Short name:
PIPkin-III
Short name:
Type III PIP kinase
Gene namesi
Name:PIKFYVE
Synonyms:KIAA0981, PIP5K3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:23785. PIKFYVE.

Subcellular locationi

GO - Cellular componenti

  • cell-cell junction Source: Ensembl
  • cytoplasmic vesicle Source: Ensembl
  • cytosol Source: Ensembl
  • early endosome membrane Source: UniProtKB
  • endosome membrane Source: UniProtKB
  • Golgi membrane Source: Reactome
  • late endosome membrane Source: Reactome
  • membrane raft Source: HGNC
  • perinuclear region of cytoplasm Source: Ensembl
  • vesicle membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Involvement in diseasei

Corneal dystrophy, fleck (CFD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of stromal corneal dystrophy characterized by numerous small white flecks scattered in all levels of the stroma, with configurations varying from semicircular to wreath-like, curvilinear, or punctate. Although CFD may occasionally cause mild photophobia, patients are typically asymptomatic and have normal vision.
See also OMIM:121850
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0253091103K → R in CFD. 1 PublicationCorresponds to variant rs121918336dbSNPEnsembl.1

Keywords - Diseasei

Corneal dystrophy, Disease mutation

Organism-specific databases

DisGeNETi200576.
MalaCardsiPIKFYVE.
MIMi121850. phenotype.
OpenTargetsiENSG00000115020.
Orphaneti98970. Fleck corneal dystrophy.
PharmGKBiPA165697116.

Chemistry databases

ChEMBLiCHEMBL1938222.

Polymorphism and mutation databases

BioMutaiPIKFYVE.
DMDMi300669693.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001854522 – 20981-phosphatidylinositol 3-phosphate 5-kinaseAdd BLAST2097

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei48PhosphoserineCombined sources1
Modified residuei88PhosphoserineCombined sources1
Modified residuei299PhosphoserineCombined sources1
Modified residuei307PhosphoserineCombined sources1
Modified residuei312PhosphoserineBy similarity1
Modified residuei318Phosphoserine; by PKB/AKT1 or PKB/AKT21 Publication1
Modified residuei329PhosphoserineCombined sources1
Modified residuei475PhosphoserineBy similarity1
Modified residuei1544PhosphoserineCombined sources1
Modified residuei1549PhosphoserineCombined sources1
Modified residuei1754PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated in response to insulin at Ser-318 in a protein kinase B (PKB)-dependent manner.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9Y2I7.
PaxDbiQ9Y2I7.
PeptideAtlasiQ9Y2I7.
PRIDEiQ9Y2I7.

PTM databases

iPTMnetiQ9Y2I7.
PhosphoSitePlusiQ9Y2I7.

Expressioni

Gene expression databases

BgeeiENSG00000115020.
CleanExiHS_PIP5K3.
ExpressionAtlasiQ9Y2I7. baseline and differential.
GenevisibleiQ9Y2I7. HS.

Organism-specific databases

HPAiHPA042604.

Interactioni

Subunit structurei

Component of the PI(3,5)P2 regulatory complex/PAS complex, at least composed of PIKFYVE, FIG4 and VAC14. VAC14 nucleates the assembly of the complex and serves as a scaffold.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
VAC14Q08AM64EBI-6138650,EBI-2107455

Protein-protein interaction databases

BioGridi128336. 10 interactors.
IntActiQ9Y2I7. 3 interactors.
MINTiMINT-3084529.
STRINGi9606.ENSP00000264380.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2I7.
SMRiQ9Y2I7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini365 – 440DEPPROSITE-ProRule annotationAdd BLAST76
Domaini1758 – 2084PIPKPROSITE-ProRule annotationAdd BLAST327

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1842 – 2098CatalyticAdd BLAST257

Sequence similaritiesi

Contains 1 DEP domain.PROSITE-ProRule annotation
Contains 1 FYVE-type zinc finger.PROSITE-ProRule annotation
Contains 1 PIPK domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri158 – 218FYVE-typePROSITE-ProRule annotationAdd BLAST61

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IMP3. Eukaryota.
KOG0230. Eukaryota.
COG0459. LUCA.
COG5253. LUCA.
GeneTreeiENSGT00840000129741.
HOGENOMiHOG000059273.
HOVERGENiHBG072055.
InParanoidiQ9Y2I7.
KOiK00921.
OMAiNRTTETE.
OrthoDBiEOG091G00JB.
PhylomeDBiQ9Y2I7.
TreeFamiTF321717.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.30.260.10. 2 hits.
3.30.40.10. 1 hit.
3.30.800.10. 1 hit.
3.30.810.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR002423. Cpn60/TCP-1.
IPR000591. DEP_dom.
IPR027409. GroEL-like_apical_dom.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
IPR027410. TCP-1-like_intermed.
IPR011991. WHTH_DNA-bd_dom.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
PF00610. DEP. 1 hit.
PF01363. FYVE. 1 hit.
PF01504. PIP5K. 2 hits.
[Graphical view]
SMARTiSM00049. DEP. 1 hit.
SM00064. FYVE. 1 hit.
SM00330. PIPKc. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF52029. SSF52029. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEiPS50186. DEP. 1 hit.
PS51455. PIPK. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y2I7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATDDKTSPT LDSANDLPRS PTSPSHLTHF KPLTPDQDEP PFKSAYSSFV
60 70 80 90 100
NLFRFNKERA EGGQGEQQPL SGSWTSPQLP SRTQSVRSPT PYKKQLNEEL
110 120 130 140 150
QRRSSALDTR RKAEPTFGGH DPRTAVQLRS LSTVLKRLKE IMEGKSQDSD
160 170 180 190 200
LKQYWMPDSQ CKECYDCSEK FTTFRRRHHC RLCGQIFCSR CCNQEIPGKF
210 220 230 240 250
MGYTGDLRAC TYCRKIALSY AHSTDSNSIG EDLNALSDSA CSVSVLDPSE
260 270 280 290 300
PRTPVGSRKA SRNIFLEDDL AWQSLIHPDS SNTPLSTRLV SVQEDAGKSP
310 320 330 340 350
ARNRSASITN LSLDRSGSPM VPSYETSVSP QANRTYVRTE TTEDERKILL
360 370 380 390 400
DSVQLKDLWK KICHHSSGME FQDHRYWLRT HPNCIVGKEL VNWLIRNGHI
410 420 430 440 450
ATRAQAIAIG QAMVDGRWLD CVSHHDQLFR DEYALYRPLQ STEFSETPSP
460 470 480 490 500
DSDSVNSVEG HSEPSWFKDI KFDDSDTEQI AEEGDDNLAN SASPSKRTSV
510 520 530 540 550
SSFQSTVDSD SAASISLNVE LDNVNFHIKK PSKYPHVPPH PADQKEYLIS
560 570 580 590 600
DTGGQQLSIS DAFIKESLFN RRVEEKSKEL PFTPLGWHHN NLELLREENG
610 620 630 640 650
EKQAMERLLS ANHNHMMALL QQLLHSDSLS SSWRDIIVSL VCQVVQTVRP
660 670 680 690 700
DVKNQDDDMD IRQFVHIKKI PGGKKFDSVV VNGFVCTKNI AHKKMSSCIK
710 720 730 740 750
NPKILLLKCS IEYLYREETK FTCIDPIVLQ EREFLKNYVQ RIVDVRPTLV
760 770 780 790 800
LVEKTVSRIA QDMLLEHGIT LVINVKSQVL ERISRMTQGD LVMSMDQLLT
810 820 830 840 850
KPHLGTCHKF YMQIFQLPNE QTKTLMFFEG CPQHLGCTIK LRGGSDYELA
860 870 880 890 900
RVKEILIFMI CVAYHSQLEI SFLMDEFAMP PTLMQNPSFH SLIEGRGHEG
910 920 930 940 950
AVQEQYGGGS IPWDPDIPPE SLPCDDSSLL ELRIVFEKGE QENKNLPQAV
960 970 980 990 1000
ASVKHQEHST TACPAGLPCA FFAPVPESLL PLPVDDQQDA LGSEQPETLQ
1010 1020 1030 1040 1050
QTVVLQDPKS QIRAFRDPLQ DDTGLYVTEE VTSSEDKRKT YSLAFKQELK
1060 1070 1080 1090 1100
DVILCISPVI TFREPFLLTE KGMRCSTRDY FAEQVYWSPL LNKEFKEMEN
1110 1120 1130 1140 1150
RRKKQLLRDL SGLQGMNGSI QAKSIQVLPS HELVSTRIAE HLGDSQSLGR
1160 1170 1180 1190 1200
MLADYRARGG RIQPKNSDPF AHSKDASSTS SGQSGSKNEG DEERGLILSD
1210 1220 1230 1240 1250
AVWSTKVDCL NPINHQRLCV LFSSSSAQSS NAPSACVSPW IVTMEFYGKN
1260 1270 1280 1290 1300
DLTLGIFLER YCFRPSYQCP SMFCDTPMVH HIRRFVHGQG CVQIILKELD
1310 1320 1330 1340 1350
SPVPGYQHTI LTYSWCRICK QVTPVVALSN ESWSMSFAKY LELRFYGHQY
1360 1370 1380 1390 1400
TRRANAEPCG HSIHHDYHQY FSYNQMVASF SYSPIRLLEV CVPLPKIFIK
1410 1420 1430 1440 1450
RQAPLKVSLL QDLKDFFQKV SQVYVAIDER LASLKTDTFS KTREEKMEDI
1460 1470 1480 1490 1500
FAQKEMEEGE FKNWIEKMQA RLMSSSVDTP QQLQSVFESL IAKKQSLCEV
1510 1520 1530 1540 1550
LQAWNNRLQD LFQQEKGRKR PSVPPSPGRL RQGEESKISA MDASPRNISP
1560 1570 1580 1590 1600
GLQNGEKEDR FLTTLSSQSS TSSTHLQLPT PPEVMSEQSV GGPPELDTAS
1610 1620 1630 1640 1650
SSEDVFDGHL LGSTDSQVKE KSTMKAIFAN LLPGNSYNPI PFPFDPDKHY
1660 1670 1680 1690 1700
LMYEHERVPI AVCEKEPSSI IAFALSCKEY RNALEELSKA TQWNSAEEGL
1710 1720 1730 1740 1750
PTNSTSDSRP KSSSPIRLPE MSGGQTNRTT ETEPQPTKKA SGMLSFFRGT
1760 1770 1780 1790 1800
AGKSPDLSSQ KRETLRGADS AYYQVGQTGK EGTENQGVEP QDEVDGGDTQ
1810 1820 1830 1840 1850
KKQLINPHVE LQFSDANAKF YCRLYYAGEF HKMREVILDS SEEDFIRSLS
1860 1870 1880 1890 1900
HSSPWQARGG KSGAAFYATE DDRFILKQMP RLEVQSFLDF APHYFNYITN
1910 1920 1930 1940 1950
AVQQKRPTAL AKILGVYRIG YKNSQNNTEK KLDLLVMENL FYGRKMAQVF
1960 1970 1980 1990 2000
DLKGSLRNRN VKTDTGKESC DVVLLDENLL KMVRDNPLYI RSHSKAVLRT
2010 2020 2030 2040 2050
SIHSDSHFLS SHLIIDYSLL VGRDDTSNEL VVGIIDYIRT FTWDKKLEMV
2060 2070 2080 2090
VKSTGILGGQ GKMPTVVSPE LYRTRFCEAM DKYFLMVPDH WTGLGLNC
Length:2,098
Mass (Da):237,136
Last modified:July 13, 2010 - v3
Checksum:i390C43530D3B1E81
GO
Isoform 2 (identifier: Q9Y2I7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     108-204: Missing.
     546-548: EYL → GRR
     549-2098: Missing.

Note: No experimental confirmation available.
Show »
Length:451
Mass (Da):50,211
Checksum:iE5C7D123475EA30E
GO
Isoform 3 (identifier: Q9Y2I7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     109-203: TRRKAEPTFG...QEIPGKFMGY → NSLQHPQEN
     546-548: EYL → GRR
     549-2098: Missing.

Note: No experimental confirmation available.
Show »
Length:462
Mass (Da):51,476
Checksum:i60E516304C47A038
GO
Isoform 4 (identifier: Q9Y2I7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     546-548: EYL → GRR
     549-2098: Missing.

Note: No experimental confirmation available.
Show »
Length:548
Mass (Da):61,595
Checksum:i46091F5266458F67
GO

Sequence cautioni

The sequence BAC03674 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1335M → I in BAC03674 (PubMed:14702039).Curated1
Sequence conflicti2019L → S in BAC03674 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057097617M → V.Corresponds to variant rs16840913dbSNPEnsembl.1
Natural variantiVAR_063406696S → N.2 PublicationsCorresponds to variant rs10932258dbSNPEnsembl.1
Natural variantiVAR_063407932L → S.2 PublicationsCorresponds to variant rs2363468dbSNPEnsembl.1
Natural variantiVAR_063408995Q → L.2 PublicationsCorresponds to variant rs893254dbSNPEnsembl.1
Natural variantiVAR_063409998T → S.2 PublicationsCorresponds to variant rs893253dbSNPEnsembl.1
Natural variantiVAR_0570981033S → A.Corresponds to variant rs999890dbSNPEnsembl.1
Natural variantiVAR_0253091103K → R in CFD. 1 PublicationCorresponds to variant rs121918336dbSNPEnsembl.1
Natural variantiVAR_0634101183Q → K.3 PublicationsCorresponds to variant rs1529979dbSNPEnsembl.1
Natural variantiVAR_0570991858R → Q.Corresponds to variant rs2289170dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_040108108 – 204Missing in isoform 2. 1 PublicationAdd BLAST97
Alternative sequenceiVSP_040109109 – 203TRRKA…KFMGY → NSLQHPQEN in isoform 3. 1 PublicationAdd BLAST95
Alternative sequenceiVSP_040110546 – 548EYL → GRR in isoform 2, isoform 3 and isoform 4. 1 Publication3
Alternative sequenceiVSP_040111549 – 2098Missing in isoform 2, isoform 3 and isoform 4. 1 PublicationAdd BLAST1550

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY457063 mRNA. Translation: AAR19397.1.
AC012362 Genomic DNA. Translation: AAY14870.1.
AC016697 Genomic DNA. Translation: AAX93222.1.
CH471063 Genomic DNA. Translation: EAW70444.1.
CH471063 Genomic DNA. Translation: EAW70445.1.
BC032389 mRNA. Translation: AAH32389.1.
BC125052 mRNA. Translation: AAI25053.1.
BC125053 mRNA. Translation: AAI25054.1.
AK091482 mRNA. Translation: BAC03674.1. Different initiation.
AB023198 mRNA. Translation: BAA76825.1.
CCDSiCCDS2382.1. [Q9Y2I7-1]
CCDS33368.1. [Q9Y2I7-2]
CCDS54431.1. [Q9Y2I7-4]
RefSeqiNP_001171471.1. NM_001178000.1. [Q9Y2I7-4]
NP_055855.2. NM_015040.3. [Q9Y2I7-1]
NP_689884.1. NM_152671.3. [Q9Y2I7-2]
UniGeneiHs.744997.

Genome annotation databases

EnsembliENST00000264380; ENSP00000264380; ENSG00000115020. [Q9Y2I7-1]
ENST00000308862; ENSP00000308715; ENSG00000115020. [Q9Y2I7-3]
ENST00000392202; ENSP00000376038; ENSG00000115020. [Q9Y2I7-2]
ENST00000407449; ENSP00000384356; ENSG00000115020. [Q9Y2I7-4]
GeneIDi200576.
KEGGihsa:200576.
UCSCiuc002vcv.4. human. [Q9Y2I7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY457063 mRNA. Translation: AAR19397.1.
AC012362 Genomic DNA. Translation: AAY14870.1.
AC016697 Genomic DNA. Translation: AAX93222.1.
CH471063 Genomic DNA. Translation: EAW70444.1.
CH471063 Genomic DNA. Translation: EAW70445.1.
BC032389 mRNA. Translation: AAH32389.1.
BC125052 mRNA. Translation: AAI25053.1.
BC125053 mRNA. Translation: AAI25054.1.
AK091482 mRNA. Translation: BAC03674.1. Different initiation.
AB023198 mRNA. Translation: BAA76825.1.
CCDSiCCDS2382.1. [Q9Y2I7-1]
CCDS33368.1. [Q9Y2I7-2]
CCDS54431.1. [Q9Y2I7-4]
RefSeqiNP_001171471.1. NM_001178000.1. [Q9Y2I7-4]
NP_055855.2. NM_015040.3. [Q9Y2I7-1]
NP_689884.1. NM_152671.3. [Q9Y2I7-2]
UniGeneiHs.744997.

3D structure databases

ProteinModelPortaliQ9Y2I7.
SMRiQ9Y2I7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128336. 10 interactors.
IntActiQ9Y2I7. 3 interactors.
MINTiMINT-3084529.
STRINGi9606.ENSP00000264380.

Chemistry databases

ChEMBLiCHEMBL1938222.

PTM databases

iPTMnetiQ9Y2I7.
PhosphoSitePlusiQ9Y2I7.

Polymorphism and mutation databases

BioMutaiPIKFYVE.
DMDMi300669693.

Proteomic databases

EPDiQ9Y2I7.
PaxDbiQ9Y2I7.
PeptideAtlasiQ9Y2I7.
PRIDEiQ9Y2I7.

Protocols and materials databases

DNASUi200576.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264380; ENSP00000264380; ENSG00000115020. [Q9Y2I7-1]
ENST00000308862; ENSP00000308715; ENSG00000115020. [Q9Y2I7-3]
ENST00000392202; ENSP00000376038; ENSG00000115020. [Q9Y2I7-2]
ENST00000407449; ENSP00000384356; ENSG00000115020. [Q9Y2I7-4]
GeneIDi200576.
KEGGihsa:200576.
UCSCiuc002vcv.4. human. [Q9Y2I7-1]

Organism-specific databases

CTDi200576.
DisGeNETi200576.
GeneCardsiPIKFYVE.
HGNCiHGNC:23785. PIKFYVE.
HPAiHPA042604.
MalaCardsiPIKFYVE.
MIMi121850. phenotype.
609414. gene.
neXtProtiNX_Q9Y2I7.
OpenTargetsiENSG00000115020.
Orphaneti98970. Fleck corneal dystrophy.
PharmGKBiPA165697116.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IMP3. Eukaryota.
KOG0230. Eukaryota.
COG0459. LUCA.
COG5253. LUCA.
GeneTreeiENSGT00840000129741.
HOGENOMiHOG000059273.
HOVERGENiHBG072055.
InParanoidiQ9Y2I7.
KOiK00921.
OMAiNRTTETE.
OrthoDBiEOG091G00JB.
PhylomeDBiQ9Y2I7.
TreeFamiTF321717.

Enzyme and pathway databases

BioCyciMetaCyc:HS03825-MONOMER.
ZFISH:HS03825-MONOMER.
BRENDAi2.7.1.150. 2681.
2.7.1.68. 2681.
ReactomeiR-HSA-1660514. Synthesis of PIPs at the Golgi membrane.
R-HSA-1660516. Synthesis of PIPs at the early endosome membrane.
R-HSA-1660517. Synthesis of PIPs at the late endosome membrane.
SIGNORiQ9Y2I7.

Miscellaneous databases

ChiTaRSiPIKFYVE. human.
GeneWikiiPIKFYVE.
GenomeRNAii200576.
PROiQ9Y2I7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000115020.
CleanExiHS_PIP5K3.
ExpressionAtlasiQ9Y2I7. baseline and differential.
GenevisibleiQ9Y2I7. HS.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.30.260.10. 2 hits.
3.30.40.10. 1 hit.
3.30.800.10. 1 hit.
3.30.810.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR002423. Cpn60/TCP-1.
IPR000591. DEP_dom.
IPR027409. GroEL-like_apical_dom.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
IPR027410. TCP-1-like_intermed.
IPR011991. WHTH_DNA-bd_dom.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
PF00610. DEP. 1 hit.
PF01363. FYVE. 1 hit.
PF01504. PIP5K. 2 hits.
[Graphical view]
SMARTiSM00049. DEP. 1 hit.
SM00064. FYVE. 1 hit.
SM00330. PIPKc. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF52029. SSF52029. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEiPS50186. DEP. 1 hit.
PS51455. PIPK. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFYV1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2I7
Secondary accession number(s): Q08AR7
, Q08AR8, Q53ST3, Q53T36, Q8N5H0, Q8NB67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 13, 2010
Last modified: November 2, 2016
This is version 164 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.