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Q9Y2I2

- NTNG1_HUMAN

UniProt

Q9Y2I2 - NTNG1_HUMAN

Protein

Netrin-G1

Gene

NTNG1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 3 (04 Jan 2005)
      Previous versions | rss
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    Functioni

    Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites.1 Publication

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. axonogenesis Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Neurogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Netrin-G1
    Alternative name(s):
    Laminet-1
    Gene namesi
    Name:NTNG1
    Synonyms:KIAA0976, LMNT1
    ORF Names:UNQ571/PRO1133
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:23319. NTNG1.

    Subcellular locationi

    Cell membrane 1 Publication; Lipid-anchorGPI-anchor 1 Publication; Extracellular side 1 Publication

    GO - Cellular componenti

    1. anchored component of plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    Orphaneti3095. Atypical Rett syndrome.
    PharmGKBiPA164742200.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 28281 PublicationAdd
    BLAST
    Chaini29 – 510482Netrin-G1PRO_0000017091Add
    BLAST
    Propeptidei511 – 53929Removed in mature formSequence AnalysisPRO_0000017092Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi33 ↔ 50By similarity
    Disulfide bondi72 ↔ 92By similarity
    Disulfide bondi80 ↔ 88
    Glycosylationi133 – 1331N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi182 ↔ 206By similarity
    Disulfide bondi297 ↔ 306By similarity
    Disulfide bondi299 ↔ 315By similarity
    Disulfide bondi317 ↔ 326By similarity
    Glycosylationi320 – 3201N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi329 ↔ 354By similarity
    Disulfide bondi364 ↔ 373By similarity
    Disulfide bondi366 ↔ 384By similarity
    Disulfide bondi387 ↔ 396By similarity
    Disulfide bondi399 ↔ 417By similarity
    Glycosylationi406 – 4061N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi420 ↔ 432By similarity
    Disulfide bondi422 ↔ 438By similarity
    Glycosylationi433 – 4331N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi440 ↔ 449By similarity
    Disulfide bondi452 ↔ 462By similarity
    Disulfide bondi467 ↔ 480By similarity
    Disulfide bondi474 ↔ 486By similarity
    Disulfide bondi488 ↔ 497By similarity
    Lipidationi510 – 5101GPI-anchor amidated serineSequence Analysis

    Post-translational modificationi

    N-glycosylated.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

    Proteomic databases

    PaxDbiQ9Y2I2.
    PRIDEiQ9Y2I2.

    PTM databases

    PhosphoSiteiQ9Y2I2.

    Expressioni

    Tissue specificityi

    Highly expressed in the thalamus, with very low expression, if any, in other tissues.2 Publications

    Gene expression databases

    ArrayExpressiQ9Y2I2.
    BgeeiQ9Y2I2.
    CleanExiHS_NTNG1.
    GenevestigatoriQ9Y2I2.

    Interactioni

    Subunit structurei

    Interacts with NGL1.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    LRRC4Q9HBW12EBI-7444396,EBI-7444327
    LRRC4CQ9HCJ24EBI-7444396,EBI-3925442

    Protein-protein interaction databases

    BioGridi116525. 1 interaction.
    IntActiQ9Y2I2. 2 interactions.
    MINTiMINT-8300827.
    STRINGi9606.ENSP00000359085.

    Structurei

    Secondary structure

    1
    539
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi33 – 364
    Beta strandi45 – 484
    Helixi57 – 593
    Beta strandi62 – 676
    Helixi68 – 703
    Beta strandi94 – 963
    Turni97 – 993
    Helixi103 – 1075
    Beta strandi118 – 1203
    Beta strandi132 – 14413
    Beta strandi148 – 1547
    Beta strandi158 – 16710
    Beta strandi173 – 1819
    Helixi182 – 1854
    Helixi193 – 1953
    Turni209 – 2113
    Beta strandi213 – 2153
    Turni216 – 2194
    Beta strandi220 – 2234
    Helixi226 – 2338
    Helixi240 – 24910
    Helixi251 – 2566
    Beta strandi257 – 26812
    Beta strandi272 – 2754
    Helixi281 – 2833
    Beta strandi287 – 2926
    Beta strandi294 – 2974
    Beta strandi300 – 3023
    Beta strandi306 – 3094
    Beta strandi312 – 3154
    Beta strandi321 – 3266
    Beta strandi345 – 3484

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3ZYJX-ray3.25B/D1-520[»]
    ProteinModelPortaliQ9Y2I2.
    SMRiQ9Y2I2. Positions 30-534.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini46 – 296251Laminin N-terminalPROSITE-ProRule annotationAdd
    BLAST
    Domaini297 – 35660Laminin EGF-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini364 – 41956Laminin EGF-like 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini420 – 46950Laminin EGF-like 3PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni80 – 9112NGL discriminant loop IAdd
    BLAST
    Regioni208 – 2147NGL discriminant loop II
    Regioni273 – 2753NGL discriminant loop III

    Domaini

    The laminin N-terminal domain mediates 1:1 binding to NGL ligand with sub-micromolar affinity. Three NGL-binding loops mediate discrimination for LRRC4C/NGL1 among other NGLs by binding specifically to its LRR repeats. This specificity drives the sorting of a mixed population of molecules into discrete cell surface subdomains.

    Sequence similaritiesi

    Contains 3 laminin EGF-like domains.PROSITE-ProRule annotation
    Contains 1 laminin N-terminal domain.CuratedPROSITE-ProRule annotation

    Keywords - Domaini

    Laminin EGF-like domain, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG286598.
    HOVERGENiHBG052676.
    KOiK07522.
    OMAiYCECFGH.
    OrthoDBiEOG7HQN7W.
    PhylomeDBiQ9Y2I2.
    TreeFamiTF333945.

    Family and domain databases

    InterProiIPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR002049. EGF_laminin.
    IPR008211. Laminin_N.
    [Graphical view]
    PfamiPF00053. Laminin_EGF. 3 hits.
    PF00055. Laminin_N. 1 hit.
    [Graphical view]
    SMARTiSM00181. EGF. 1 hit.
    SM00180. EGF_Lam. 3 hits.
    SM00136. LamNT. 1 hit.
    [Graphical view]
    PROSITEiPS00022. EGF_1. 3 hits.
    PS50026. EGF_3. 1 hit.
    PS01248. EGF_LAM_1. 1 hit.
    PS50027. EGF_LAM_2. 3 hits.
    PS51117. LAMININ_NTER. 1 hit.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform 3 (identifier: Q9Y2I2-3) [UniParc]FASTAAdd to Basket

    Also known as: 1A

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MYLSRFLSIH ALWVTVSSVM QPYPLVWGHY DLCKTQIYTE EGKVWDYMAC    50
    QPESTDMTKY LKVKLDPPDI TCGDPPETFC AMGNPYMCNN ECDASTPELA 100
    HPPELMFDFE GRHPSTFWQS ATWKEYPKPL QVNITLSWSK TIELTDNIVI 150
    TFESGRPDQM ILEKSLDYGR TWQPYQYYAT DCLDAFHMDP KSVKDLSQHT 200
    VLEIICTEEY STGYTTNSKI IHFEIKDRFA FFAGPRLRNM ASLYGQLDTT 250
    KKLRDFFTVT DLRIRLLRPA VGEIFVDELH LARYFYAISD IKVRGRCKCN 300
    LHATVCVYDN SKLTCECEHN TTGPDCGKCK KNYQGRPWSP GSYLPIPKGT 350
    ANTCIPSISS IGNCECFGHS NRCSYIDLLN TVICVSCKHN TRGQHCELCR 400
    LGYFRNASAQ LDDENVCIEC YCNPLGSIHD RCNGSGFCEC KTGTTGPKCD 450
    ECLPGNSWHY GCQPNVCDNE LLHCQNGGTC HNNVRCLCPA AYTGILCEKL 500
    RCEEAGSCGS DSGQGAPPHG SPALLLLTTL LGTASPLVF 539

    Note: Mostly expressed in adult brain.

    Length:539
    Mass (Da):60,541
    Last modified:January 4, 2005 - v3
    Checksum:iC51F872D7A2C60A6
    GO
    Isoform 2 (identifier: Q9Y2I2-2) [UniParc]FASTAAdd to Basket

    Also known as: 1F

    The sequence of this isoform differs from the canonical sequence as follows:
         363-364: NC → SK
         365-539: Missing.

    Show »
    Length:364
    Mass (Da):41,759
    Checksum:iB23DAF4BEDE9271C
    GO
    Isoform 1 (identifier: Q9Y2I2-1) [UniParc]FASTAAdd to Basket

    Also known as: 1C

    The sequence of this isoform differs from the canonical sequence as follows:
         363-463: Missing.
         464-464: P → T

    Note: Hi expression in Expressed in brain and.

    Show »
    Length:438
    Mass (Da):49,340
    Checksum:iBBBA6167FAC8DD71
    GO
    Isoform 4 (identifier: Q9Y2I2-4) [UniParc]FASTAAdd to Basket

    Also known as: 1D

    The sequence of this isoform differs from the canonical sequence as follows:
         364-464: CECFGHSNRC...GNSWHYGCQP → PPKFNRIWPN...SVQVANHKRA

    Note: Mostly expressed in kidney, also expressed in adult and fetal brain.

    Show »
    Length:480
    Mass (Da):53,946
    Checksum:i9099C3CF4D3F7B86
    GO
    Isoform 5 (identifier: Q9Y2I2-5) [UniParc]FASTAAdd to Basket

    Also known as: 1E

    The sequence of this isoform differs from the canonical sequence as follows:
         364-385: CECFGHSNRCSYIDLLNTVICV → PPKFNRIWPNISSLEVSNPKQA
         386-464: Missing.

    Note: Some expression in fetal brain.

    Show »
    Length:460
    Mass (Da):51,858
    Checksum:i8217255F4C8C4C65
    GO
    Isoform 6 (identifier: Q9Y2I2-6) [UniParc]FASTAAdd to Basket

    Also known as: 1G

    The sequence of this isoform differs from the canonical sequence as follows:
         419-463: Missing.
         464-464: P → A

    Note: No experimental confirmation available.

    Show »
    Length:494
    Mass (Da):55,660
    Checksum:iF6783893CC0FE0D8
    GO

    Sequence cautioni

    The sequence BAA76820.2 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti6 – 61F → S in AAQ88731. (PubMed:12975309)Curated
    Sequence conflicti231 – 2311F → L in AAQ88731. (PubMed:12975309)Curated
    Sequence conflicti521 – 5211S → T in AAQ88731. (PubMed:12975309)Curated
    Isoform 2 (identifier: Q9Y2I2-2)
    Sequence conflicti364 – 3641K → KQ in CAD98143. (PubMed:17974005)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei363 – 463101Missing in isoform 1. 2 PublicationsVSP_012574Add
    BLAST
    Alternative sequencei363 – 3642NC → SK in isoform 2. 2 PublicationsVSP_010429
    Alternative sequencei364 – 464101CECFG…YGCQP → PPKFNRIWPNISSLEVSNPK QVAPKLALSTVSSVQVANHK RA in isoform 4. CuratedVSP_012575Add
    BLAST
    Alternative sequencei364 – 38522CECFG…TVICV → PPKFNRIWPNISSLEVSNPK QA in isoform 5. CuratedVSP_012576Add
    BLAST
    Alternative sequencei365 – 539175Missing in isoform 2. 2 PublicationsVSP_010430Add
    BLAST
    Alternative sequencei386 – 46479Missing in isoform 5. CuratedVSP_012577Add
    BLAST
    Alternative sequencei419 – 46345Missing in isoform 6. CuratedVSP_012578Add
    BLAST
    Alternative sequencei464 – 4641P → T in isoform 1. 2 PublicationsVSP_012579
    Alternative sequencei464 – 4641P → A in isoform 6. CuratedVSP_012580

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB023193 mRNA. Translation: BAA76820.2. Different initiation.
    AY358365 mRNA. Translation: AAQ88731.1.
    BX538348 mRNA. Translation: CAD98143.1.
    AL590427, AL513187 Genomic DNA. Translation: CAH73380.1.
    AL590427, AC114491, AL513187 Genomic DNA. Translation: CAH73381.1.
    AL590427, AC114491, AL513187 Genomic DNA. Translation: CAH73382.1.
    AL590427, AC114491, AL513187 Genomic DNA. Translation: CAH73383.1.
    AL590427, AC114491, AL513187 Genomic DNA. Translation: CAH73384.1.
    AL590427, AC114491, AL513187 Genomic DNA. Translation: CAH73385.1.
    AL513187, AL590427 Genomic DNA. Translation: CAH73828.1.
    AL513187, AC114491, AL590427 Genomic DNA. Translation: CAH73829.1.
    AL513187, AC114491, AL590427 Genomic DNA. Translation: CAH73830.1.
    AL513187, AC114491, AL590427 Genomic DNA. Translation: CAH73831.1.
    AL513187, AC114491, AL590427 Genomic DNA. Translation: CAH73832.1.
    AL513187, AC114491, AL590427 Genomic DNA. Translation: CAH73833.1.
    BC030220 mRNA. Translation: AAH30220.1.
    CCDSiCCDS30785.1. [Q9Y2I2-1]
    CCDS44179.1. [Q9Y2I2-4]
    CCDS44180.1. [Q9Y2I2-3]
    RefSeqiNP_001106697.1. NM_001113226.1. [Q9Y2I2-3]
    NP_001106699.1. NM_001113228.1. [Q9Y2I2-4]
    NP_055732.2. NM_014917.2. [Q9Y2I2-1]
    XP_006710519.1. XM_006710456.1. [Q9Y2I2-1]
    UniGeneiHs.732535.

    Genome annotation databases

    EnsembliENST00000370065; ENSP00000359082; ENSG00000162631. [Q9Y2I2-6]
    ENST00000370066; ENSP00000359083; ENSG00000162631. [Q9Y2I2-4]
    ENST00000370067; ENSP00000359084; ENSG00000162631. [Q9Y2I2-5]
    ENST00000370068; ENSP00000359085; ENSG00000162631. [Q9Y2I2-3]
    ENST00000370071; ENSP00000359088; ENSG00000162631. [Q9Y2I2-4]
    ENST00000370073; ENSP00000359090; ENSG00000162631. [Q9Y2I2-3]
    ENST00000370074; ENSP00000359091; ENSG00000162631. [Q9Y2I2-1]
    GeneIDi22854.
    KEGGihsa:22854.
    UCSCiuc001dvc.4. human. [Q9Y2I2-1]
    uc001dvd.1. human. [Q9Y2I2-2]
    uc001dvf.4. human. [Q9Y2I2-4]
    uc001dvh.4. human. [Q9Y2I2-3]

    Polymorphism databases

    DMDMi57015420.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB023193 mRNA. Translation: BAA76820.2 . Different initiation.
    AY358365 mRNA. Translation: AAQ88731.1 .
    BX538348 mRNA. Translation: CAD98143.1 .
    AL590427 , AL513187 Genomic DNA. Translation: CAH73380.1 .
    AL590427 , AC114491 , AL513187 Genomic DNA. Translation: CAH73381.1 .
    AL590427 , AC114491 , AL513187 Genomic DNA. Translation: CAH73382.1 .
    AL590427 , AC114491 , AL513187 Genomic DNA. Translation: CAH73383.1 .
    AL590427 , AC114491 , AL513187 Genomic DNA. Translation: CAH73384.1 .
    AL590427 , AC114491 , AL513187 Genomic DNA. Translation: CAH73385.1 .
    AL513187 , AL590427 Genomic DNA. Translation: CAH73828.1 .
    AL513187 , AC114491 , AL590427 Genomic DNA. Translation: CAH73829.1 .
    AL513187 , AC114491 , AL590427 Genomic DNA. Translation: CAH73830.1 .
    AL513187 , AC114491 , AL590427 Genomic DNA. Translation: CAH73831.1 .
    AL513187 , AC114491 , AL590427 Genomic DNA. Translation: CAH73832.1 .
    AL513187 , AC114491 , AL590427 Genomic DNA. Translation: CAH73833.1 .
    BC030220 mRNA. Translation: AAH30220.1 .
    CCDSi CCDS30785.1. [Q9Y2I2-1 ]
    CCDS44179.1. [Q9Y2I2-4 ]
    CCDS44180.1. [Q9Y2I2-3 ]
    RefSeqi NP_001106697.1. NM_001113226.1. [Q9Y2I2-3 ]
    NP_001106699.1. NM_001113228.1. [Q9Y2I2-4 ]
    NP_055732.2. NM_014917.2. [Q9Y2I2-1 ]
    XP_006710519.1. XM_006710456.1. [Q9Y2I2-1 ]
    UniGenei Hs.732535.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3ZYJ X-ray 3.25 B/D 1-520 [» ]
    ProteinModelPortali Q9Y2I2.
    SMRi Q9Y2I2. Positions 30-534.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116525. 1 interaction.
    IntActi Q9Y2I2. 2 interactions.
    MINTi MINT-8300827.
    STRINGi 9606.ENSP00000359085.

    PTM databases

    PhosphoSitei Q9Y2I2.

    Polymorphism databases

    DMDMi 57015420.

    Proteomic databases

    PaxDbi Q9Y2I2.
    PRIDEi Q9Y2I2.

    Protocols and materials databases

    DNASUi 22854.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000370065 ; ENSP00000359082 ; ENSG00000162631 . [Q9Y2I2-6 ]
    ENST00000370066 ; ENSP00000359083 ; ENSG00000162631 . [Q9Y2I2-4 ]
    ENST00000370067 ; ENSP00000359084 ; ENSG00000162631 . [Q9Y2I2-5 ]
    ENST00000370068 ; ENSP00000359085 ; ENSG00000162631 . [Q9Y2I2-3 ]
    ENST00000370071 ; ENSP00000359088 ; ENSG00000162631 . [Q9Y2I2-4 ]
    ENST00000370073 ; ENSP00000359090 ; ENSG00000162631 . [Q9Y2I2-3 ]
    ENST00000370074 ; ENSP00000359091 ; ENSG00000162631 . [Q9Y2I2-1 ]
    GeneIDi 22854.
    KEGGi hsa:22854.
    UCSCi uc001dvc.4. human. [Q9Y2I2-1 ]
    uc001dvd.1. human. [Q9Y2I2-2 ]
    uc001dvf.4. human. [Q9Y2I2-4 ]
    uc001dvh.4. human. [Q9Y2I2-3 ]

    Organism-specific databases

    CTDi 22854.
    GeneCardsi GC01P107682.
    HGNCi HGNC:23319. NTNG1.
    MIMi 608818. gene.
    neXtProti NX_Q9Y2I2.
    Orphaneti 3095. Atypical Rett syndrome.
    PharmGKBi PA164742200.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG286598.
    HOVERGENi HBG052676.
    KOi K07522.
    OMAi YCECFGH.
    OrthoDBi EOG7HQN7W.
    PhylomeDBi Q9Y2I2.
    TreeFami TF333945.

    Miscellaneous databases

    ChiTaRSi NTNG1. human.
    GeneWikii NTNG1.
    GenomeRNAii 22854.
    NextBioi 43337.
    PROi Q9Y2I2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y2I2.
    Bgeei Q9Y2I2.
    CleanExi HS_NTNG1.
    Genevestigatori Q9Y2I2.

    Family and domain databases

    InterProi IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR002049. EGF_laminin.
    IPR008211. Laminin_N.
    [Graphical view ]
    Pfami PF00053. Laminin_EGF. 3 hits.
    PF00055. Laminin_N. 1 hit.
    [Graphical view ]
    SMARTi SM00181. EGF. 1 hit.
    SM00180. EGF_Lam. 3 hits.
    SM00136. LamNT. 1 hit.
    [Graphical view ]
    PROSITEi PS00022. EGF_1. 3 hits.
    PS50026. EGF_3. 1 hit.
    PS01248. EGF_LAM_1. 1 hit.
    PS50027. EGF_LAM_2. 3 hits.
    PS51117. LAMININ_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Cerebellum.
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 1; 2; 3; 4; 5 AND 6).
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung.
    6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 29-43.
    7. "The netrin-G1 ligand NGL-1 promotes the outgrowth of thalamocortical axons."
      Lin J.C., Ho W.-H., Gurney A.L., Rosenthal A.
      Nat. Neurosci. 6:1270-1276(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NGL1, TISSUE SPECIFICITY.
    8. Cited for: ALTERNATIVE SPLICING (ISOFORMS 1; 3; 4 AND 5), TISSUE SPECIFICITY.
    9. "Structural basis for cell surface patterning through NetrinG-NGL interactions."
      Seiradake E., Coles C.H., Perestenko P.V., Harlos K., McIlhinney R.A., Aricescu A.R., Jones E.Y.
      EMBO J. 30:4479-4488(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.25 ANGSTROMS) OF 1-520 IN COMPLEX WITH LRRC4C/NGL1, FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiNTNG1_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y2I2
    Secondary accession number(s): Q5VU86
    , Q5VU87, Q5VU89, Q5VU90, Q5VU91, Q7Z2Y3, Q8N633
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2003
    Last sequence update: January 4, 2005
    Last modified: October 1, 2014
    This is version 127 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3