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Q9Y2I2

- NTNG1_HUMAN

UniProt

Q9Y2I2 - NTNG1_HUMAN

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Protein

Netrin-G1

Gene
NTNG1, KIAA0976, LMNT1, UNQ571/PRO1133
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites.1 Publication

GO - Molecular functioni

  1. protein binding Source: UniProtKB

GO - Biological processi

  1. axonogenesis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Netrin-G1
Alternative name(s):
Laminet-1
Gene namesi
Name:NTNG1
Synonyms:KIAA0976, LMNT1
ORF Names:UNQ571/PRO1133
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:23319. NTNG1.

Subcellular locationi

Cell membrane; Lipid-anchorGPI-anchor; Extracellular side 1 Publication

GO - Cellular componenti

  1. anchored component of plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

Orphaneti3095. Atypical Rett syndrome.
PharmGKBiPA164742200.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 28281 PublicationAdd
BLAST
Chaini29 – 510482Netrin-G1PRO_0000017091Add
BLAST
Propeptidei511 – 53929Removed in mature form Reviewed predictionPRO_0000017092Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 50 By similarity
Disulfide bondi72 ↔ 92 By similarity
Disulfide bondi80 ↔ 88
Glycosylationi133 – 1331N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi182 ↔ 206 By similarity
Disulfide bondi297 ↔ 306 By similarity
Disulfide bondi299 ↔ 315 By similarity
Disulfide bondi317 ↔ 326 By similarity
Glycosylationi320 – 3201N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi329 ↔ 354 By similarity
Disulfide bondi364 ↔ 373 By similarity
Disulfide bondi366 ↔ 384 By similarity
Disulfide bondi387 ↔ 396 By similarity
Disulfide bondi399 ↔ 417 By similarity
Glycosylationi406 – 4061N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi420 ↔ 432 By similarity
Disulfide bondi422 ↔ 438 By similarity
Glycosylationi433 – 4331N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi440 ↔ 449 By similarity
Disulfide bondi452 ↔ 462 By similarity
Disulfide bondi467 ↔ 480 By similarity
Disulfide bondi474 ↔ 486 By similarity
Disulfide bondi488 ↔ 497 By similarity
Lipidationi510 – 5101GPI-anchor amidated serine Reviewed prediction

Post-translational modificationi

N-glycosylated By similarity.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ9Y2I2.
PRIDEiQ9Y2I2.

PTM databases

PhosphoSiteiQ9Y2I2.

Expressioni

Tissue specificityi

Highly expressed in the thalamus, with very low expression, if any, in other tissues.2 Publications

Gene expression databases

ArrayExpressiQ9Y2I2.
BgeeiQ9Y2I2.
CleanExiHS_NTNG1.
GenevestigatoriQ9Y2I2.

Interactioni

Subunit structurei

Interacts with NGL1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
LRRC4Q9HBW12EBI-7444396,EBI-7444327
LRRC4CQ9HCJ24EBI-7444396,EBI-3925442

Protein-protein interaction databases

BioGridi116525. 1 interaction.
IntActiQ9Y2I2. 2 interactions.
MINTiMINT-8300827.
STRINGi9606.ENSP00000359085.

Structurei

Secondary structure

1
539
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi33 – 364
Beta strandi45 – 484
Helixi57 – 593
Beta strandi62 – 676
Helixi68 – 703
Beta strandi94 – 963
Turni97 – 993
Helixi103 – 1075
Beta strandi118 – 1203
Beta strandi132 – 14413
Beta strandi148 – 1547
Beta strandi158 – 16710
Beta strandi173 – 1819
Helixi182 – 1854
Helixi193 – 1953
Turni209 – 2113
Beta strandi213 – 2153
Turni216 – 2194
Beta strandi220 – 2234
Helixi226 – 2338
Helixi240 – 24910
Helixi251 – 2566
Beta strandi257 – 26812
Beta strandi272 – 2754
Helixi281 – 2833
Beta strandi287 – 2926
Beta strandi294 – 2974
Beta strandi300 – 3023
Beta strandi306 – 3094
Beta strandi312 – 3154
Beta strandi321 – 3266
Beta strandi345 – 3484

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZYJX-ray3.25B/D1-520[»]
ProteinModelPortaliQ9Y2I2.
SMRiQ9Y2I2. Positions 30-534.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 296251Laminin N-terminalAdd
BLAST
Domaini297 – 35660Laminin EGF-like 1Add
BLAST
Domaini364 – 41956Laminin EGF-like 2Add
BLAST
Domaini420 – 46950Laminin EGF-like 3Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni80 – 9112NGL discriminant loop IAdd
BLAST
Regioni208 – 2147NGL discriminant loop II
Regioni273 – 2753NGL discriminant loop III

Domaini

The laminin N-terminal domain mediates 1:1 binding to NGL ligand with sub-micromolar affinity. Three NGL-binding loops mediate discrimination for LRRC4C/NGL1 among other NGLs by binding specifically to its LRR repeats. This specificity drives the sorting of a mixed population of molecules into discrete cell surface subdomains.

Sequence similaritiesi

Keywords - Domaini

Laminin EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG286598.
HOVERGENiHBG052676.
KOiK07522.
OMAiYCECFGH.
OrthoDBiEOG7HQN7W.
PhylomeDBiQ9Y2I2.
TreeFamiTF333945.

Family and domain databases

InterProiIPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR002049. EGF_laminin.
IPR008211. Laminin_N.
[Graphical view]
PfamiPF00053. Laminin_EGF. 3 hits.
PF00055. Laminin_N. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 1 hit.
SM00180. EGF_Lam. 3 hits.
SM00136. LamNT. 1 hit.
[Graphical view]
PROSITEiPS00022. EGF_1. 3 hits.
PS50026. EGF_3. 1 hit.
PS01248. EGF_LAM_1. 1 hit.
PS50027. EGF_LAM_2. 3 hits.
PS51117. LAMININ_NTER. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. Align

Isoform 3 (identifier: Q9Y2I2-3) [UniParc]FASTAAdd to Basket

Also known as: 1A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MYLSRFLSIH ALWVTVSSVM QPYPLVWGHY DLCKTQIYTE EGKVWDYMAC    50
QPESTDMTKY LKVKLDPPDI TCGDPPETFC AMGNPYMCNN ECDASTPELA 100
HPPELMFDFE GRHPSTFWQS ATWKEYPKPL QVNITLSWSK TIELTDNIVI 150
TFESGRPDQM ILEKSLDYGR TWQPYQYYAT DCLDAFHMDP KSVKDLSQHT 200
VLEIICTEEY STGYTTNSKI IHFEIKDRFA FFAGPRLRNM ASLYGQLDTT 250
KKLRDFFTVT DLRIRLLRPA VGEIFVDELH LARYFYAISD IKVRGRCKCN 300
LHATVCVYDN SKLTCECEHN TTGPDCGKCK KNYQGRPWSP GSYLPIPKGT 350
ANTCIPSISS IGNCECFGHS NRCSYIDLLN TVICVSCKHN TRGQHCELCR 400
LGYFRNASAQ LDDENVCIEC YCNPLGSIHD RCNGSGFCEC KTGTTGPKCD 450
ECLPGNSWHY GCQPNVCDNE LLHCQNGGTC HNNVRCLCPA AYTGILCEKL 500
RCEEAGSCGS DSGQGAPPHG SPALLLLTTL LGTASPLVF 539

Note: Mostly expressed in adult brain.

Length:539
Mass (Da):60,541
Last modified:January 4, 2005 - v3
Checksum:iC51F872D7A2C60A6
GO
Isoform 2 (identifier: Q9Y2I2-2) [UniParc]FASTAAdd to Basket

Also known as: 1F

The sequence of this isoform differs from the canonical sequence as follows:
     363-364: NC → SK
     365-539: Missing.

Show »
Length:364
Mass (Da):41,759
Checksum:iB23DAF4BEDE9271C
GO
Isoform 1 (identifier: Q9Y2I2-1) [UniParc]FASTAAdd to Basket

Also known as: 1C

The sequence of this isoform differs from the canonical sequence as follows:
     363-463: Missing.
     464-464: P → T

Note: Hi expression in Expressed in brain and.

Show »
Length:438
Mass (Da):49,340
Checksum:iBBBA6167FAC8DD71
GO
Isoform 4 (identifier: Q9Y2I2-4) [UniParc]FASTAAdd to Basket

Also known as: 1D

The sequence of this isoform differs from the canonical sequence as follows:
     364-464: CECFGHSNRC...GNSWHYGCQP → PPKFNRIWPN...SVQVANHKRA

Note: Mostly expressed in kidney, also expressed in adult and fetal brain.

Show »
Length:480
Mass (Da):53,946
Checksum:i9099C3CF4D3F7B86
GO
Isoform 5 (identifier: Q9Y2I2-5) [UniParc]FASTAAdd to Basket

Also known as: 1E

The sequence of this isoform differs from the canonical sequence as follows:
     364-385: CECFGHSNRCSYIDLLNTVICV → PPKFNRIWPNISSLEVSNPKQA
     386-464: Missing.

Note: Some expression in fetal brain.

Show »
Length:460
Mass (Da):51,858
Checksum:i8217255F4C8C4C65
GO
Isoform 6 (identifier: Q9Y2I2-6) [UniParc]FASTAAdd to Basket

Also known as: 1G

The sequence of this isoform differs from the canonical sequence as follows:
     419-463: Missing.
     464-464: P → A

Note: No experimental confirmation available.

Show »
Length:494
Mass (Da):55,660
Checksum:iF6783893CC0FE0D8
GO

Sequence cautioni

The sequence BAA76820.2 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei363 – 463101Missing in isoform 1. VSP_012574Add
BLAST
Alternative sequencei363 – 3642NC → SK in isoform 2. VSP_010429
Alternative sequencei364 – 464101CECFG…YGCQP → PPKFNRIWPNISSLEVSNPK QVAPKLALSTVSSVQVANHK RA in isoform 4. VSP_012575Add
BLAST
Alternative sequencei364 – 38522CECFG…TVICV → PPKFNRIWPNISSLEVSNPK QA in isoform 5. VSP_012576Add
BLAST
Alternative sequencei365 – 539175Missing in isoform 2. VSP_010430Add
BLAST
Alternative sequencei386 – 46479Missing in isoform 5. VSP_012577Add
BLAST
Alternative sequencei419 – 46345Missing in isoform 6. VSP_012578Add
BLAST
Alternative sequencei464 – 4641P → T in isoform 1. VSP_012579
Alternative sequencei464 – 4641P → A in isoform 6. VSP_012580

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61F → S in AAQ88731. 1 Publication
Sequence conflicti231 – 2311F → L in AAQ88731. 1 Publication
Sequence conflicti521 – 5211S → T in AAQ88731. 1 Publication
Isoform 2 (identifier: Q9Y2I2-2)
Sequence conflicti364 – 3641K → KQ in CAD98143. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB023193 mRNA. Translation: BAA76820.2. Different initiation.
AY358365 mRNA. Translation: AAQ88731.1.
BX538348 mRNA. Translation: CAD98143.1.
AL590427, AL513187 Genomic DNA. Translation: CAH73380.1.
AL590427, AC114491, AL513187 Genomic DNA. Translation: CAH73381.1.
AL590427, AC114491, AL513187 Genomic DNA. Translation: CAH73382.1.
AL590427, AC114491, AL513187 Genomic DNA. Translation: CAH73383.1.
AL590427, AC114491, AL513187 Genomic DNA. Translation: CAH73384.1.
AL590427, AC114491, AL513187 Genomic DNA. Translation: CAH73385.1.
AL513187, AL590427 Genomic DNA. Translation: CAH73828.1.
AL513187, AC114491, AL590427 Genomic DNA. Translation: CAH73829.1.
AL513187, AC114491, AL590427 Genomic DNA. Translation: CAH73830.1.
AL513187, AC114491, AL590427 Genomic DNA. Translation: CAH73831.1.
AL513187, AC114491, AL590427 Genomic DNA. Translation: CAH73832.1.
AL513187, AC114491, AL590427 Genomic DNA. Translation: CAH73833.1.
BC030220 mRNA. Translation: AAH30220.1.
CCDSiCCDS30785.1. [Q9Y2I2-1]
CCDS44179.1. [Q9Y2I2-4]
CCDS44180.1. [Q9Y2I2-3]
RefSeqiNP_001106697.1. NM_001113226.1. [Q9Y2I2-3]
NP_001106699.1. NM_001113228.1. [Q9Y2I2-4]
NP_055732.2. NM_014917.2. [Q9Y2I2-1]
XP_006710519.1. XM_006710456.1. [Q9Y2I2-1]
UniGeneiHs.732535.

Genome annotation databases

EnsembliENST00000370065; ENSP00000359082; ENSG00000162631. [Q9Y2I2-6]
ENST00000370066; ENSP00000359083; ENSG00000162631. [Q9Y2I2-4]
ENST00000370067; ENSP00000359084; ENSG00000162631. [Q9Y2I2-5]
ENST00000370068; ENSP00000359085; ENSG00000162631. [Q9Y2I2-3]
ENST00000370071; ENSP00000359088; ENSG00000162631. [Q9Y2I2-4]
ENST00000370073; ENSP00000359090; ENSG00000162631. [Q9Y2I2-3]
ENST00000370074; ENSP00000359091; ENSG00000162631. [Q9Y2I2-1]
GeneIDi22854.
KEGGihsa:22854.
UCSCiuc001dvc.4. human. [Q9Y2I2-1]
uc001dvd.1. human. [Q9Y2I2-2]
uc001dvf.4. human. [Q9Y2I2-4]
uc001dvh.4. human. [Q9Y2I2-3]

Polymorphism databases

DMDMi57015420.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB023193 mRNA. Translation: BAA76820.2 . Different initiation.
AY358365 mRNA. Translation: AAQ88731.1 .
BX538348 mRNA. Translation: CAD98143.1 .
AL590427 , AL513187 Genomic DNA. Translation: CAH73380.1 .
AL590427 , AC114491 , AL513187 Genomic DNA. Translation: CAH73381.1 .
AL590427 , AC114491 , AL513187 Genomic DNA. Translation: CAH73382.1 .
AL590427 , AC114491 , AL513187 Genomic DNA. Translation: CAH73383.1 .
AL590427 , AC114491 , AL513187 Genomic DNA. Translation: CAH73384.1 .
AL590427 , AC114491 , AL513187 Genomic DNA. Translation: CAH73385.1 .
AL513187 , AL590427 Genomic DNA. Translation: CAH73828.1 .
AL513187 , AC114491 , AL590427 Genomic DNA. Translation: CAH73829.1 .
AL513187 , AC114491 , AL590427 Genomic DNA. Translation: CAH73830.1 .
AL513187 , AC114491 , AL590427 Genomic DNA. Translation: CAH73831.1 .
AL513187 , AC114491 , AL590427 Genomic DNA. Translation: CAH73832.1 .
AL513187 , AC114491 , AL590427 Genomic DNA. Translation: CAH73833.1 .
BC030220 mRNA. Translation: AAH30220.1 .
CCDSi CCDS30785.1. [Q9Y2I2-1 ]
CCDS44179.1. [Q9Y2I2-4 ]
CCDS44180.1. [Q9Y2I2-3 ]
RefSeqi NP_001106697.1. NM_001113226.1. [Q9Y2I2-3 ]
NP_001106699.1. NM_001113228.1. [Q9Y2I2-4 ]
NP_055732.2. NM_014917.2. [Q9Y2I2-1 ]
XP_006710519.1. XM_006710456.1. [Q9Y2I2-1 ]
UniGenei Hs.732535.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3ZYJ X-ray 3.25 B/D 1-520 [» ]
ProteinModelPortali Q9Y2I2.
SMRi Q9Y2I2. Positions 30-534.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116525. 1 interaction.
IntActi Q9Y2I2. 2 interactions.
MINTi MINT-8300827.
STRINGi 9606.ENSP00000359085.

PTM databases

PhosphoSitei Q9Y2I2.

Polymorphism databases

DMDMi 57015420.

Proteomic databases

PaxDbi Q9Y2I2.
PRIDEi Q9Y2I2.

Protocols and materials databases

DNASUi 22854.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000370065 ; ENSP00000359082 ; ENSG00000162631 . [Q9Y2I2-6 ]
ENST00000370066 ; ENSP00000359083 ; ENSG00000162631 . [Q9Y2I2-4 ]
ENST00000370067 ; ENSP00000359084 ; ENSG00000162631 . [Q9Y2I2-5 ]
ENST00000370068 ; ENSP00000359085 ; ENSG00000162631 . [Q9Y2I2-3 ]
ENST00000370071 ; ENSP00000359088 ; ENSG00000162631 . [Q9Y2I2-4 ]
ENST00000370073 ; ENSP00000359090 ; ENSG00000162631 . [Q9Y2I2-3 ]
ENST00000370074 ; ENSP00000359091 ; ENSG00000162631 . [Q9Y2I2-1 ]
GeneIDi 22854.
KEGGi hsa:22854.
UCSCi uc001dvc.4. human. [Q9Y2I2-1 ]
uc001dvd.1. human. [Q9Y2I2-2 ]
uc001dvf.4. human. [Q9Y2I2-4 ]
uc001dvh.4. human. [Q9Y2I2-3 ]

Organism-specific databases

CTDi 22854.
GeneCardsi GC01P107682.
HGNCi HGNC:23319. NTNG1.
MIMi 608818. gene.
neXtProti NX_Q9Y2I2.
Orphaneti 3095. Atypical Rett syndrome.
PharmGKBi PA164742200.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG286598.
HOVERGENi HBG052676.
KOi K07522.
OMAi YCECFGH.
OrthoDBi EOG7HQN7W.
PhylomeDBi Q9Y2I2.
TreeFami TF333945.

Miscellaneous databases

ChiTaRSi NTNG1. human.
GeneWikii NTNG1.
GenomeRNAii 22854.
NextBioi 43337.
PROi Q9Y2I2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9Y2I2.
Bgeei Q9Y2I2.
CleanExi HS_NTNG1.
Genevestigatori Q9Y2I2.

Family and domain databases

InterProi IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR002049. EGF_laminin.
IPR008211. Laminin_N.
[Graphical view ]
Pfami PF00053. Laminin_EGF. 3 hits.
PF00055. Laminin_N. 1 hit.
[Graphical view ]
SMARTi SM00181. EGF. 1 hit.
SM00180. EGF_Lam. 3 hits.
SM00136. LamNT. 1 hit.
[Graphical view ]
PROSITEi PS00022. EGF_1. 3 hits.
PS50026. EGF_3. 1 hit.
PS01248. EGF_LAM_1. 1 hit.
PS50027. EGF_LAM_2. 3 hits.
PS51117. LAMININ_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Cerebellum.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 1; 2; 3; 4; 5 AND 6).
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung.
  6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 29-43.
  7. "The netrin-G1 ligand NGL-1 promotes the outgrowth of thalamocortical axons."
    Lin J.C., Ho W.-H., Gurney A.L., Rosenthal A.
    Nat. Neurosci. 6:1270-1276(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NGL1, TISSUE SPECIFICITY.
  8. Cited for: ALTERNATIVE SPLICING (ISOFORMS 1; 3; 4 AND 5), TISSUE SPECIFICITY.
  9. "Structural basis for cell surface patterning through NetrinG-NGL interactions."
    Seiradake E., Coles C.H., Perestenko P.V., Harlos K., McIlhinney R.A., Aricescu A.R., Jones E.Y.
    EMBO J. 30:4479-4488(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.25 ANGSTROMS) OF 1-520 IN COMPLEX WITH LRRC4C/NGL1, FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiNTNG1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2I2
Secondary accession number(s): Q5VU86
, Q5VU87, Q5VU89, Q5VU90, Q5VU91, Q7Z2Y3, Q8N633
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: January 4, 2005
Last modified: July 9, 2014
This is version 126 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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