Q9Y2I2 (NTNG1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Netrin-G1

Alternative name(s):
Laminet-1

Gene names

Name:	NTNG1
Synonyms:	KIAA0976, LMNT1
ORF Names:	UNQ571/PRO1133

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	539 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites. Ref.9
Subunit structure	Interacts with NGL1. Ref.7
Subcellular location	Cell membrane; Lipid-anchor › GPI-anchor; Extracellular side Ref.9.
Tissue specificity	Highly expressed in the thalamus, with very low expression, if any, in other tissues. Ref.7 Ref.8
Domain	The laminin N-terminal domain mediates 1:1 binding to NGL ligand with sub-micromolar affinity. Three NGL-binding loops mediate discrimination for LRRC4C/NGL1 among other NGLs by binding specifically to its LRR repeats. This specificity drives the sorting of a mixed population of molecules into discrete cell surface subdomains.
Post-translational modification	N-glycosylated By similarity. UniProtKB Q8R4G0
Sequence similarities	Contains 3 laminin EGF-like domains. Contains 1 laminin N-terminal domain.
Sequence caution	The sequence BAA76820.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing
Domain	Laminin EGF-like domain Repeat Signal
Molecular function	Developmental protein
PTM	Disulfide bond GPI-anchor Glycoprotein Lipoprotein
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	axonogenesis Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	anchored to plasma membrane Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 3 (identifier: Q9Y2I2-3)

Also known as: 1A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: Mostly expressed in adult brain.

Isoform 2 (identifier: Q9Y2I2-2)

Also known as: 1F;

The sequence of this isoform differs from the canonical sequence as follows:
     363-364: NC → SK
     365-539: Missing.

Isoform 1 (identifier: Q9Y2I2-1)

Also known as: 1C;

The sequence of this isoform differs from the canonical sequence as follows:
     363-463: Missing.
     464-464: P → T

Note: Hi expression in Expressed in brain and.

Isoform 4 (identifier: Q9Y2I2-4)

Also known as: 1D;

The sequence of this isoform differs from the canonical sequence as follows:
     364-464: CECFGHSNRC...GNSWHYGCQP → PPKFNRIWPN...SVQVANHKRA

Note: Mostly expressed in kidney, also expressed in adult and fetal brain.

Isoform 5 (identifier: Q9Y2I2-5)

Also known as: 1E;

The sequence of this isoform differs from the canonical sequence as follows:
     364-385: CECFGHSNRCSYIDLLNTVICV → PPKFNRIWPNISSLEVSNPKQA
     386-464: Missing.

Note: Some expression in fetal brain.

Isoform 6 (identifier: Q9Y2I2-6)

Also known as: 1G;

The sequence of this isoform differs from the canonical sequence as follows:
     419-463: Missing.
     464-464: P → A

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 28

28

Ref.6

Chain

29 – 510

482

Netrin-G1

PRO_0000017091

Propeptide

511 – 539

29

Removed in mature form Potential

PRO_0000017092

Regions

Domain

46 – 296

251

Laminin N-terminal

Domain

297 – 356

60

Laminin EGF-like 1

Domain

364 – 419

56

Laminin EGF-like 2

Domain

420 – 469

50

Laminin EGF-like 3

Region

80 – 91

12

NGL discriminant loop I

Region

208 – 214

7

NGL discriminant loop II

Region

273 – 275

3

NGL discriminant loop III

Amino acid modifications

Lipidation

510

1

GPI-anchor amidated serine Potential

Glycosylation

133

1

N-linked (GlcNAc...) Potential

Glycosylation

320

1

N-linked (GlcNAc...) Potential

Glycosylation

406

1

N-linked (GlcNAc...) Potential

Glycosylation

433

1

N-linked (GlcNAc...) Potential

Disulfide bond

33 ↔ 50

By similarity

Disulfide bond

72 ↔ 92

By similarity

Disulfide bond

80 ↔ 88

Disulfide bond

182 ↔ 206

By similarity

Disulfide bond

297 ↔ 306

By similarity

Disulfide bond

299 ↔ 315

By similarity

Disulfide bond

317 ↔ 326

By similarity

Disulfide bond

329 ↔ 354

By similarity

Disulfide bond

364 ↔ 373

By similarity

Disulfide bond

366 ↔ 384

By similarity

Disulfide bond

387 ↔ 396

By similarity

Disulfide bond

399 ↔ 417

By similarity

Disulfide bond

420 ↔ 432

By similarity

Disulfide bond

422 ↔ 438

By similarity

Disulfide bond

440 ↔ 449

By similarity

Disulfide bond

452 ↔ 462

By similarity

Disulfide bond

467 ↔ 480

By similarity

Disulfide bond

474 ↔ 486

By similarity

Disulfide bond

488 ↔ 497

By similarity

Natural variations

Alternative sequence

363 – 463

101

Missing in isoform 1.

VSP_012574

Alternative sequence

363 – 364

2

NC → SK in isoform 2.

VSP_010429

Alternative sequence

364 – 464

101

CECFG…YGCQP → PPKFNRIWPNISSLEVSNPK QVAPKLALSTVSSVQVANHK RA in isoform 4.

VSP_012575

Alternative sequence

364 – 385

22

CECFG…TVICV → PPKFNRIWPNISSLEVSNPK QA in isoform 5.

VSP_012576

Alternative sequence

365 – 539

175

Missing in isoform 2.

VSP_010430

Alternative sequence

386 – 464

79

Missing in isoform 5.

VSP_012577

Alternative sequence

419 – 463

45

Missing in isoform 6.

VSP_012578

Alternative sequence

464

1

P → T in isoform 1.

VSP_012579

Alternative sequence

464

1

P → A in isoform 6.

VSP_012580

Experimental info

Sequence conflict

6

1

F → S in AAQ88731. Ref.2

Sequence conflict

231

1

F → L in AAQ88731. Ref.2

Sequence conflict

521

1

S → T in AAQ88731. Ref.2

Isoform 2:

Sequence conflict

364

1

K → KQ in CAD98143. Ref.3

Secondary structure

1

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539

Helix Strand Turn

Details...

Beta strand

33 – 36

4

Beta strand

45 – 48

4

Helix

57 – 59

3

Beta strand

62 – 67

6

Helix

68 – 70

3

Beta strand

94 – 96

3

Turn

97 – 99

3

Helix

103 – 107

5

Beta strand

118 – 120

3

Beta strand

132 – 144

13

Beta strand

148 – 154

7

Beta strand

158 – 167

10

Beta strand

173 – 181

9

Helix

182 – 185

4

Helix

193 – 195

3

Turn

209 – 211

3

Beta strand

213 – 215

3

Turn

216 – 219

4

Beta strand

220 – 223

4

Helix

226 – 233

8

Helix

240 – 249

10

Helix

251 – 256

6

Beta strand

257 – 268

12

Beta strand

272 – 275

4

Helix

281 – 283

3

Beta strand

287 – 292

6

Beta strand

294 – 297

4

Beta strand

300 – 302

3

Beta strand

306 – 309

4

Beta strand

312 – 315

4

Beta strand

321 – 326

6

Beta strand

345 – 348

4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 3 (1A) [UniParc]. Last modified January 4, 2005. Version 3. Checksum: C51F872D7A2C60A6	FASTA	539	60,541
	10 20 30 40 50 60 MYLSRFLSIH ALWVTVSSVM QPYPLVWGHY DLCKTQIYTE EGKVWDYMAC QPESTDMTKY 70 80 90 100 110 120 LKVKLDPPDI TCGDPPETFC AMGNPYMCNN ECDASTPELA HPPELMFDFE GRHPSTFWQS 130 140 150 160 170 180 ATWKEYPKPL QVNITLSWSK TIELTDNIVI TFESGRPDQM ILEKSLDYGR TWQPYQYYAT 190 200 210 220 230 240 DCLDAFHMDP KSVKDLSQHT VLEIICTEEY STGYTTNSKI IHFEIKDRFA FFAGPRLRNM 250 260 270 280 290 300 ASLYGQLDTT KKLRDFFTVT DLRIRLLRPA VGEIFVDELH LARYFYAISD IKVRGRCKCN 310 320 330 340 350 360 LHATVCVYDN SKLTCECEHN TTGPDCGKCK KNYQGRPWSP GSYLPIPKGT ANTCIPSISS 370 380 390 400 410 420 IGNCECFGHS NRCSYIDLLN TVICVSCKHN TRGQHCELCR LGYFRNASAQ LDDENVCIEC 430 440 450 460 470 480 YCNPLGSIHD RCNGSGFCEC KTGTTGPKCD ECLPGNSWHY GCQPNVCDNE LLHCQNGGTC 490 500 510 520 530 HNNVRCLCPA AYTGILCEKL RCEEAGSCGS DSGQGAPPHG SPALLLLTTL LGTASPLVF
	Isoform 2 (1F) [UniParc]. Checksum: B23DAF4BEDE9271C	FASTA	364	41,759
	10 20 30 40 50 60 MYLSRFLSIH ALWVTVSSVM QPYPLVWGHY DLCKTQIYTE EGKVWDYMAC QPESTDMTKY 70 80 90 100 110 120 LKVKLDPPDI TCGDPPETFC AMGNPYMCNN ECDASTPELA HPPELMFDFE GRHPSTFWQS 130 140 150 160 170 180 ATWKEYPKPL QVNITLSWSK TIELTDNIVI TFESGRPDQM ILEKSLDYGR TWQPYQYYAT 190 200 210 220 230 240 DCLDAFHMDP KSVKDLSQHT VLEIICTEEY STGYTTNSKI IHFEIKDRFA FFAGPRLRNM 250 260 270 280 290 300 ASLYGQLDTT KKLRDFFTVT DLRIRLLRPA VGEIFVDELH LARYFYAISD IKVRGRCKCN 310 320 330 340 350 360 LHATVCVYDN SKLTCECEHN TTGPDCGKCK KNYQGRPWSP GSYLPIPKGT ANTCIPSISS IGSK
	Isoform 1 (1C) [UniParc]. Checksum: BBBA6167FAC8DD71	FASTA	438	49,340
	10 20 30 40 50 60 MYLSRFLSIH ALWVTVSSVM QPYPLVWGHY DLCKTQIYTE EGKVWDYMAC QPESTDMTKY 70 80 90 100 110 120 LKVKLDPPDI TCGDPPETFC AMGNPYMCNN ECDASTPELA HPPELMFDFE GRHPSTFWQS 130 140 150 160 170 180 ATWKEYPKPL QVNITLSWSK TIELTDNIVI TFESGRPDQM ILEKSLDYGR TWQPYQYYAT 190 200 210 220 230 240 DCLDAFHMDP KSVKDLSQHT VLEIICTEEY STGYTTNSKI IHFEIKDRFA FFAGPRLRNM 250 260 270 280 290 300 ASLYGQLDTT KKLRDFFTVT DLRIRLLRPA VGEIFVDELH LARYFYAISD IKVRGRCKCN 310 320 330 340 350 360 LHATVCVYDN SKLTCECEHN TTGPDCGKCK KNYQGRPWSP GSYLPIPKGT ANTCIPSISS 370 380 390 400 410 420 IGTNVCDNEL LHCQNGGTCH NNVRCLCPAA YTGILCEKLR CEEAGSCGSD SGQGAPPHGS 430 PALLLLTTLL GTASPLVF
	Isoform 4 (1D) [UniParc]. Checksum: 9099C3CF4D3F7B86	FASTA	480	53,946
	10 20 30 40 50 60 MYLSRFLSIH ALWVTVSSVM QPYPLVWGHY DLCKTQIYTE EGKVWDYMAC QPESTDMTKY 70 80 90 100 110 120 LKVKLDPPDI TCGDPPETFC AMGNPYMCNN ECDASTPELA HPPELMFDFE GRHPSTFWQS 130 140 150 160 170 180 ATWKEYPKPL QVNITLSWSK TIELTDNIVI TFESGRPDQM ILEKSLDYGR TWQPYQYYAT 190 200 210 220 230 240 DCLDAFHMDP KSVKDLSQHT VLEIICTEEY STGYTTNSKI IHFEIKDRFA FFAGPRLRNM 250 260 270 280 290 300 ASLYGQLDTT KKLRDFFTVT DLRIRLLRPA VGEIFVDELH LARYFYAISD IKVRGRCKCN 310 320 330 340 350 360 LHATVCVYDN SKLTCECEHN TTGPDCGKCK KNYQGRPWSP GSYLPIPKGT ANTCIPSISS 370 380 390 400 410 420 IGNPPKFNRI WPNISSLEVS NPKQVAPKLA LSTVSSVQVA NHKRANVCDN ELLHCQNGGT 430 440 450 460 470 480 CHNNVRCLCP AAYTGILCEK LRCEEAGSCG SDSGQGAPPH GSPALLLLTT LLGTASPLVF
	Isoform 5 (1E) [UniParc]. Checksum: 8217255F4C8C4C65	FASTA	460	51,858
	10 20 30 40 50 60 MYLSRFLSIH ALWVTVSSVM QPYPLVWGHY DLCKTQIYTE EGKVWDYMAC QPESTDMTKY 70 80 90 100 110 120 LKVKLDPPDI TCGDPPETFC AMGNPYMCNN ECDASTPELA HPPELMFDFE GRHPSTFWQS 130 140 150 160 170 180 ATWKEYPKPL QVNITLSWSK TIELTDNIVI TFESGRPDQM ILEKSLDYGR TWQPYQYYAT 190 200 210 220 230 240 DCLDAFHMDP KSVKDLSQHT VLEIICTEEY STGYTTNSKI IHFEIKDRFA FFAGPRLRNM 250 260 270 280 290 300 ASLYGQLDTT KKLRDFFTVT DLRIRLLRPA VGEIFVDELH LARYFYAISD IKVRGRCKCN 310 320 330 340 350 360 LHATVCVYDN SKLTCECEHN TTGPDCGKCK KNYQGRPWSP GSYLPIPKGT ANTCIPSISS 370 380 390 400 410 420 IGNPPKFNRI WPNISSLEVS NPKQANVCDN ELLHCQNGGT CHNNVRCLCP AAYTGILCEK 430 440 450 460 LRCEEAGSCG SDSGQGAPPH GSPALLLLTT LLGTASPLVF
	Isoform 6 (1G) [UniParc]. Checksum: F6783893CC0FE0D8	FASTA	494	55,660
	10 20 30 40 50 60 MYLSRFLSIH ALWVTVSSVM QPYPLVWGHY DLCKTQIYTE EGKVWDYMAC QPESTDMTKY 70 80 90 100 110 120 LKVKLDPPDI TCGDPPETFC AMGNPYMCNN ECDASTPELA HPPELMFDFE GRHPSTFWQS 130 140 150 160 170 180 ATWKEYPKPL QVNITLSWSK TIELTDNIVI TFESGRPDQM ILEKSLDYGR TWQPYQYYAT 190 200 210 220 230 240 DCLDAFHMDP KSVKDLSQHT VLEIICTEEY STGYTTNSKI IHFEIKDRFA FFAGPRLRNM 250 260 270 280 290 300 ASLYGQLDTT KKLRDFFTVT DLRIRLLRPA VGEIFVDELH LARYFYAISD IKVRGRCKCN 310 320 330 340 350 360 LHATVCVYDN SKLTCECEHN TTGPDCGKCK KNYQGRPWSP GSYLPIPKGT ANTCIPSISS 370 380 390 400 410 420 IGNCECFGHS NRCSYIDLLN TVICVSCKHN TRGQHCELCR LGYFRNASAQ LDDENVCIAN 430 440 450 460 470 480 VCDNELLHCQ NGGTCHNNVR CLCPAAYTGI LCEKLRCEEA GSCGSDSGQG APPHGSPALL 490 LLTTLLGTAS PLVF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Cerebellum.
[4]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 1; 2; 3; 4; 5 AND 6).
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Lung.
[6]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 29-43.
[7]	"The netrin-G1 ligand NGL-1 promotes the outgrowth of thalamocortical axons." Lin J.C., Ho W.-H., Gurney A.L., Rosenthal A. Nat. Neurosci. 6:1270-1276(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH NGL1, TISSUE SPECIFICITY.
[8]	"Human netrin-G1 isoforms show evidence of differential expression." Meerabux J.M., Ohba H., Fukasawa M., Suto Y., Aoki-Suzuki M., Nakashiba T., Nishimura S., Itohara S., Yoshikawa T. Genomics 86:112-116(2005) [PubMed] [Europe PMC] [Abstract] Cited for: ALTERNATIVE SPLICING (ISOFORMS 1; 3; 4 AND 5), TISSUE SPECIFICITY.
[9]	"Structural basis for cell surface patterning through NetrinG-NGL interactions." Seiradake E., Coles C.H., Perestenko P.V., Harlos K., McIlhinney R.A., Aricescu A.R., Jones E.Y. EMBO J. 30:4479-4488(2011) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.25 ANGSTROMS) OF 1-520 IN COMPLEX WITH LRRC4C/NGL1, FUNCTION, SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AB023193 mRNA. Translation: BAA76820.2. Different initiation.
AY358365 mRNA. Translation: AAQ88731.1.
BX538348 mRNA. Translation: CAD98143.1.
AL590427, AL513187 Genomic DNA. Translation: CAH73380.1.
AL590427, AC114491, AL513187 Genomic DNA. Translation: CAH73381.1.
AL590427, AC114491, AL513187 Genomic DNA. Translation: CAH73382.1.
AL590427, AC114491, AL513187 Genomic DNA. Translation: CAH73383.1.
AL590427, AC114491, AL513187 Genomic DNA. Translation: CAH73384.1.
AL590427, AC114491, AL513187 Genomic DNA. Translation: CAH73385.1.
AL513187, AL590427 Genomic DNA. Translation: CAH73828.1.
AL513187, AC114491, AL590427 Genomic DNA. Translation: CAH73829.1.
AL513187, AC114491, AL590427 Genomic DNA. Translation: CAH73830.1.
AL513187, AC114491, AL590427 Genomic DNA. Translation: CAH73831.1.
AL513187, AC114491, AL590427 Genomic DNA. Translation: CAH73832.1.
AL513187, AC114491, AL590427 Genomic DNA. Translation: CAH73833.1.
BC030220 mRNA. Translation: AAH30220.1.

IPI

IPI00412988.
IPI00412989.
IPI00477903.
IPI00478407.
IPI00478746.
IPI00479203.

RefSeq

NP_001106697.1. NM_001113226.1.
NP_001106699.1. NM_001113228.1.
NP_055732.2. NM_014917.2.

UniGene

Hs.732535.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3ZYJ	X-ray	3.25	B/D	1-520	[»]

ProteinModelPortal

Q9Y2I2.

ModBase

Search...

Protein-protein interaction databases

STRING

9606.ENSP00000359085.

PTM databases

PhosphoSite

Q9Y2I2.

Polymorphism databases

DMDM

57015420.

Proteomic databases

PaxDb

Q9Y2I2.

PRIDE

Q9Y2I2.

Protocols and materials databases

DNASU

22854.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000294649; ENSP00000294649; ENSG00000162631.
ENST00000370065; ENSP00000359082; ENSG00000162631.
ENST00000370066; ENSP00000359083; ENSG00000162631.
ENST00000370067; ENSP00000359084; ENSG00000162631.
ENST00000370068; ENSP00000359085; ENSG00000162631.
ENST00000370071; ENSP00000359088; ENSG00000162631.
ENST00000370073; ENSP00000359090; ENSG00000162631.
ENST00000370074; ENSP00000359091; ENSG00000162631.
ENST00000370076; ENSP00000359093; ENSG00000162631.

GeneID

22854.

KEGG

hsa:22854.

UCSC

uc001dvc.4. human.
uc001dvd.1. human.
uc001dvf.4. human.
uc001dvh.4. human.

Organism-specific databases

CTD

22854.

GeneCards

GC01P107682.

HGNC

HGNC:23319. NTNG1.

MIM

608818. gene.

neXtProt

NX_Q9Y2I2.

Orphanet

3095. Atypical Rett syndrome.

PharmGKB

PA164742200.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG286598.

HOVERGEN

HBG052676.

KO

K07522.

OMA

YCECFGH.

Gene expression databases

ArrayExpress

Q9Y2I2.

Bgee

Q9Y2I2.

CleanEx

HS_NTNG1.

Genevestigator

Q9Y2I2.

GermOnline

ENSG00000162631. Homo sapiens.

Family and domain databases

InterPro

IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR002049. EGF_laminin.
IPR008211. Laminin_N.
[Graphical view]

Pfam

PF00053. Laminin_EGF. 3 hits.
PF00055. Laminin_N. 1 hit.
[Graphical view]

SMART

SM00181. EGF. 1 hit.
SM00180. EGF_Lam. 3 hits.
SM00136. LamNT. 1 hit.
[Graphical view]

PROSITE

PS00022. EGF_1. 3 hits.
PS01186. EGF_2. False negative.
PS50026. EGF_3. 1 hit.
PS01248. EGF_LAM_1. 1 hit.
PS50027. EGF_LAM_2. 3 hits.
PS51117. LAMININ_NTER. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

NTNG1. human.

GenomeRNAi

22854.

NextBio

43337.

SOURCE

Search...

Entry information

Entry name

NTNG1_HUMAN

Accession

Primary (citable) accession number: Q9Y2I2
Secondary accession number(s): Q5VU86 , Q5VU87, Q5VU89, Q5VU90, Q5VU91, Q7Z2Y3, Q8N633

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2003
Last sequence update:	January 4, 2005
Last modified:	May 1, 2013
This is version 115 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.