##gff-version 3 Q9Y2H9 UniProtKB Chain 1 1570 . . . ID=PRO_0000086309;Note=Microtubule-associated serine/threonine-protein kinase 1 Q9Y2H9 UniProtKB Domain 374 647 . . . Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Q9Y2H9 UniProtKB Domain 648 719 . . . Note=AGC-kinase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00618 Q9Y2H9 UniProtKB Domain 967 1055 . . . Note=PDZ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143 Q9Y2H9 UniProtKB Region 23 80 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9Y2H9 UniProtKB Region 94 117 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9Y2H9 UniProtKB Region 139 171 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9Y2H9 UniProtKB Region 340 374 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9Y2H9 UniProtKB Region 717 909 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9Y2H9 UniProtKB Region 929 965 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9Y2H9 UniProtKB Region 1065 1184 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9Y2H9 UniProtKB Region 1200 1293 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9Y2H9 UniProtKB Region 1305 1570 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9Y2H9 UniProtKB Compositional bias 32 46 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9Y2H9 UniProtKB Compositional bias 62 78 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9Y2H9 UniProtKB Compositional bias 140 154 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9Y2H9 UniProtKB Compositional bias 357 373 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9Y2H9 UniProtKB Compositional bias 740 760 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9Y2H9 UniProtKB Compositional bias 808 823 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9Y2H9 UniProtKB Compositional bias 934 965 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9Y2H9 UniProtKB Compositional bias 1078 1094 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9Y2H9 UniProtKB Compositional bias 1097 1177 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9Y2H9 UniProtKB Compositional bias 1221 1239 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9Y2H9 UniProtKB Compositional bias 1278 1293 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9Y2H9 UniProtKB Active site 497 497 . . . Note=Proton acceptor;Ontology_term=ECO:0000250,ECO:0000255,ECO:0000255;evidence=ECO:0000250|UniProtKB:Q9BXM7,ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027 Q9Y2H9 UniProtKB Binding site 380 388 . . . Ontology_term=ECO:0000250,ECO:0000255;evidence=ECO:0000250|UniProtKB:Q9BXM7,ECO:0000255|PROSITE-ProRule:PRU00159 Q9Y2H9 UniProtKB Binding site 403 403 . . . Ontology_term=ECO:0000250,ECO:0000255;evidence=ECO:0000250|UniProtKB:Q9BXM7,ECO:0000255|PROSITE-ProRule:PRU00159 Q9Y2H9 UniProtKB Modified residue 90 90 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9R1L5 Q9Y2H9 UniProtKB Modified residue 139 139 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9R1L5 Q9Y2H9 UniProtKB Modified residue 167 167 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9R1L5 Q9Y2H9 UniProtKB Modified residue 346 346 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q810W7 Q9Y2H9 UniProtKB Modified residue 351 351 . . . Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q810W7 Q9Y2H9 UniProtKB Modified residue 687 687 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q810W7 Q9Y2H9 UniProtKB Modified residue 893 893 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9R1L5 Q9Y2H9 UniProtKB Modified residue 952 952 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q810W7 Q9Y2H9 UniProtKB Modified residue 1413 1413 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q810W7 Q9Y2H9 UniProtKB Natural variant 93 93 . . . ID=VAR_081872;Note=In a patient with neurodevelopmental abnormalities%3B uncertain significance. S->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30449657;Dbxref=dbSNP:rs878853165,PMID:30449657 Q9Y2H9 UniProtKB Natural variant 98 98 . . . ID=VAR_081873;Note=In a patient with neurodevelopmental abnormalities%3B uncertain significance. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30449657;Dbxref=PMID:30449657 Q9Y2H9 UniProtKB Natural variant 195 195 . . . ID=VAR_081874;Note=In MCCCHCM%3B uncertain significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30449657;Dbxref=dbSNP:rs1568408280,PMID:30449657 Q9Y2H9 UniProtKB Natural variant 269 269 . . . ID=VAR_040768;Note=In a metastatic melanoma sample%3B somatic mutation. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846 Q9Y2H9 UniProtKB Natural variant 277 277 . . . ID=VAR_081875;Note=In MCCCHCM. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30449657;Dbxref=dbSNP:rs1568409494,PMID:30449657 Q9Y2H9 UniProtKB Natural variant 279 279 . . . ID=VAR_081876;Note=In MCCCHCM%3B expression of this variant in transgenic mice results in thicker corpus callosum%2C hypoplastic cortex and hypoplastic cerebellum. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30449657;Dbxref=PMID:30449657 Q9Y2H9 UniProtKB Natural variant 517 517 . . . ID=VAR_081877;Note=In MCCCHCM. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30449657;Dbxref=dbSNP:rs1568413207,PMID:30449657 Q9Y2H9 UniProtKB Natural variant 915 915 . . . ID=VAR_081878;Note=In a patient with neurodevelopmental abnormalities%3B uncertain significance. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30449657;Dbxref=PMID:30449657 Q9Y2H9 UniProtKB Natural variant 1048 1048 . . . ID=VAR_051644;Note=A->S;Dbxref=dbSNP:rs35052801 Q9Y2H9 UniProtKB Natural variant 1177 1177 . . . ID=VAR_081879;Note=In a patient with neurodevelopmental abnormalities%3B uncertain significance. P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30449657;Dbxref=PMID:30449657 Q9Y2H9 UniProtKB Natural variant 1240 1240 . . . ID=VAR_040769;Note=In an ovarian serous carcinoma sample%3B somatic mutation. H->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs1411105125,PMID:17344846 Q9Y2H9 UniProtKB Natural variant 1292 1292 . . . ID=VAR_040770;Note=P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35071862,PMID:17344846 Q9Y2H9 UniProtKB Helix 189 202 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2M9X Q9Y2H9 UniProtKB Helix 216 237 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2M9X Q9Y2H9 UniProtKB Helix 242 261 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2M9X Q9Y2H9 UniProtKB Helix 268 281 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2M9X Q9Y2H9 UniProtKB Beta strand 968 971 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3PS4 Q9Y2H9 UniProtKB Beta strand 973 975 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3PS4 Q9Y2H9 UniProtKB Beta strand 978 987 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3PS4 Q9Y2H9 UniProtKB Beta strand 994 1003 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3PS4 Q9Y2H9 UniProtKB Helix 1008 1012 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3PS4 Q9Y2H9 UniProtKB Beta strand 1019 1023 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3PS4 Q9Y2H9 UniProtKB Helix 1033 1042 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3PS4 Q9Y2H9 UniProtKB Turn 1043 1045 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3PS4 Q9Y2H9 UniProtKB Beta strand 1046 1052 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3PS4