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Q9Y2H9 (MAST1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 125. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Microtubule-associated serine/threonine-protein kinase 1

EC=2.7.11.1
Alternative name(s):
Syntrophin-associated serine/threonine-protein kinase
Gene names
Name:MAST1
Synonyms:KIAA0973, SAST
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1570 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins By similarity. UniProtKB Q9R1L5

Catalytic activity

ATP + a protein = ADP + a phosphoprotein. UniProtKB Q9BXM7

Cofactor

Magnesium By similarity. UniProtKB Q9BXM7

Subunit structure

Part of a low affinity complex that associates with, but is distinct from, the postsynaptic density. Interacts with SNTB2 By similarity. UniProtKB Q9R1L5

Subcellular location

Cell membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cytoplasmcytoskeleton By similarity. Note: Colocalizes with syntrophins at the cell membrane By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

Contains 1 AGC-kinase C-terminal domain.

Contains 1 PDZ (DHR) domain.

Contains 1 protein kinase domain.

Sequence caution

The sequence AAB51171.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence AAH27985.2 differs from that shown. Reason: Erroneous initiation.

The sequence BAA76817.1 differs from that shown. Reason: Erroneous initiation.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

EGFRP005332EBI-3385920,EBI-297353

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 15701570Microtubule-associated serine/threonine-protein kinase 1
PRO_0000086309

Regions

Domain374 – 647274Protein kinase
Domain648 – 71972AGC-kinase C-terminal
Domain967 – 105589PDZ
Nucleotide binding380 – 3889ATP By similarity UniProtKB Q9BXM7

Sites

Active site4971Proton acceptor By similarity UniProtKB Q9BXM7
Binding site4031ATP By similarity UniProtKB Q9BXM7

Natural variations

Natural variant2691A → T in a metastatic melanoma sample; somatic mutation. Ref.4
VAR_040768
Natural variant10481A → S.
Corresponds to variant rs35052801 [ dbSNP | Ensembl ].
VAR_051644
Natural variant12401H → Y in an ovarian serous carcinoma sample; somatic mutation. Ref.4
VAR_040769
Natural variant12921P → S. Ref.4
Corresponds to variant rs35071862 [ dbSNP | Ensembl ].
VAR_040770

Secondary structure

......................... 1570
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9Y2H9 [UniParc].

Last modified March 1, 2005. Version 2.
Checksum: 189D24AE07B62A1E

FASTA1,570170,677
        10         20         30         40         50         60 
MSDSLWTALS NFSMPSFPGG SMFRRTKSCR TSNRKSLILT STSPTLPRPH SPLPGHLGSS 

        70         80         90        100        110        120 
PLDSPRNFSP NTPAHFSFAS SRRADGRRWS LASLPSSGYG TNTPSSTVSS SCSSQERLHQ 

       130        140        150        160        170        180 
LPYQPTVDEL HFLSKHFGST ESITDEDGGR RSPAVRPRSR SLSPGRSPSS YDNEIVMMNH 

       190        200        210        220        230        240 
VYKERFPKAT AQMEEKLRDF TRAYEPDSVL PLADGVLSFI HHQIIELARD CLTKSRDGLI 

       250        260        270        280        290        300 
TTVYFYELQE NLEKLLQDAY ERSESLEVAF VTQLVKKLLI IISRPARLLE CLEFNPEEFY 

       310        320        330        340        350        360 
HLLEAAEGHA KEGHLVKTDI PRYIIRQLGL TRDPFPDVVH LEEQDSGGSN TPEQDDLSEG 

       370        380        390        400        410        420 
RSSKAKKPPG ENDFDTIKLI SNGAYGAVYL VRHRDTRQRF AMKKINKQNL ILRNQIQQAF 

       430        440        450        460        470        480 
VERDILTFAE NPFVVGMFCS FETRRHLCMV MEYVEGGDCA TLLKNIGALP VEMARMYFAE 

       490        500        510        520        530        540 
TVLALEYLHN YGIVHRDLKP DNLLITSMGH IKLTDFGLSK MGLMSLTTNL YEGHIEKDAR 

       550        560        570        580        590        600 
EFLDKQVCGT PEYIAPEVIL RQGYGKPVDW WAMGIILYEF LVGCVPFFGD TPEELFGQVI 

       610        620        630        640        650        660 
SDDILWPEGD EALPTEAQLL ISSLLQTNPL VRLGAGGAFE VKQHSFFRDL DWTGLLRQKA 

       670        680        690        700        710        720 
EFIPHLESED DTSYFDTRSD RYHHVNSYDE DDTTEEEPVE IRQFSSCSPR FSKVYSSMEQ 

       730        740        750        760        770        780 
LSQHEPKTPV AAAGSSKREP STKGPEEKVA GKREGLGGLT LREKTWRGGS PEIKRFSASE 

       790        800        810        820        830        840 
ASFLEGEASP PLGARRRFSA LLEPSRFSAP QEDEDEARLR RPPRPSSDPA GSLDARAPKE 

       850        860        870        880        890        900 
ETQGEGTSSA GDSEATDRPR PGDLCPPSKD GDASGPRATN DLVLRRARHQ QMSGDVAVEK 

       910        920        930        940        950        960 
RPSRTGGKVI KSASATALSV MIPAVDPHGS SPLASPMSPR SLSSNPSSRD SSPSRDYSPA 

       970        980        990       1000       1010       1020 
VSGLRSPITI QRSGKKYGFT LRAIRVYMGD TDVYSVHHIV WHVEEGGPAQ EAGLCAGDLI 

      1030       1040       1050       1060       1070       1080 
THVNGEPVHG MVHPEVVELI LKSGNKVAVT TTPFENTSIR IGPARRSSYK AKMARRNKRP 

      1090       1100       1110       1120       1130       1140 
SAKEGQESKK RSSLFRKITK QSNLLHTSRS LSSLNRSLSS SDSLPGSPTH GLPARSPTHS 

      1150       1160       1170       1180       1190       1200 
YRSTPDSAYL GASSQSSSPA SSTPNSPASS ASHHIRPSTL HGLSPKLHRQ YRSARCKSAG 

      1210       1220       1230       1240       1250       1260 
NIPLSPLAHT PSPTQASPPP LPGHTVGSSH TTQSFPAKLH SSPPVVRPRP KSAEPPRSPL 

      1270       1280       1290       1300       1310       1320 
LKRVQSAEKL GASLSADKKG ALRKHSLEVG HPDFRKDFHG ELALHSLAES DGETPPVEGL 

      1330       1340       1350       1360       1370       1380 
GAPRQVAVRR LGRQESPLSL GADPLLPEGA SRPPVSSKEK ESPGGAEACT PPRATTPGGR 

      1390       1400       1410       1420       1430       1440 
TLERDVGCTR HQSVQTEDGT GGMARAVAKA ALSPVQEHET GRRSSSGEAG TPLVPIVVEP 

      1450       1460       1470       1480       1490       1500 
ARPGAKAVVP QPLGADSKGL QEPAPLAPSV PEAPRGRERW VLEVVEERTT LSGPRSKPAS 

      1510       1520       1530       1540       1550       1560 
PKLSPEPQTP SLAPAKCSAP SSAVTPVPPA SLLGSGTKPQ VGLTSRCPAE AVPPAGLTKK 

      1570 
GVSSPAPPGP 

« Hide

References

[1]"Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[2]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 390-1570.
Tissue: Brain.
[4]"Patterns of somatic mutation in human cancer genomes."
Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. expand/collapse author list , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-269; TYR-1240 AND SER-1292.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB023190 mRNA. Translation: BAA76817.1. Different initiation.
AC020934 Genomic DNA. No translation available.
AD000092 Genomic DNA. Translation: AAB51171.1. Sequence problems.
BC027985 mRNA. Translation: AAH27985.2. Different initiation.
PIRT45070.
RefSeqNP_055790.1. NM_014975.2.
UniGeneHs.227489.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2M9XNMR-A187-287[»]
3PS4X-ray1.85A/B/C/D965-1057[»]
ProteinModelPortalQ9Y2H9.
SMRQ9Y2H9. Positions 185-713, 965-1057.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116632. 36 interactions.
IntActQ9Y2H9. 32 interactions.
STRING9606.ENSP00000251472.

Chemistry

BindingDBQ9Y2H9.
ChEMBLCHEMBL1163128.
GuidetoPHARMACOLOGY1510.

PTM databases

PhosphoSiteQ9Y2H9.

Polymorphism databases

DMDM60390226.

Proteomic databases

PaxDbQ9Y2H9.
PeptideAtlasQ9Y2H9.
PRIDEQ9Y2H9.

Protocols and materials databases

DNASU22983.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000251472; ENSP00000251472; ENSG00000105613.
GeneID22983.
KEGGhsa:22983.
UCSCuc002mvm.3. human.

Organism-specific databases

CTD22983.
GeneCardsGC19P012949.
HGNCHGNC:19034. MAST1.
HPAHPA028181.
MIM612256. gene.
neXtProtNX_Q9Y2H9.
PharmGKBPA134946727.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000046662.
HOVERGENHBG052414.
InParanoidQ9Y2H9.
KOK08789.
OMAGCTRHQS.
OrthoDBEOG7PK8ZC.
PhylomeDBQ9Y2H9.
TreeFamTF313149.

Enzyme and pathway databases

SignaLinkQ9Y2H9.

Gene expression databases

ArrayExpressQ9Y2H9.
BgeeQ9Y2H9.
CleanExHS_MAST1.
GenevestigatorQ9Y2H9.

Family and domain databases

Gene3D1.20.1480.20. 1 hit.
2.30.42.10. 1 hit.
InterProIPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR015022. MA_Ser/Thr_Kinase_dom.
IPR028777. MAST1.
IPR023142. MAST_pre-PK_dom.
IPR001478. PDZ.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERPTHR24356:SF118. PTHR24356:SF118. 1 hit.
PfamPF08926. DUF1908. 1 hit.
PF00595. PDZ. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00228. PDZ. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF140482. SSF140482. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEPS51285. AGC_KINASE_CTER. 1 hit.
PS50106. PDZ. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSMAST1. human.
EvolutionaryTraceQ9Y2H9.
GeneWikiMAST1.
GenomeRNAi22983.
NextBio43815.
PROQ9Y2H9.
SOURCESearch...

Entry information

Entry nameMAST1_HUMAN
AccessionPrimary (citable) accession number: Q9Y2H9
Secondary accession number(s): O00114, Q8N6X0
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: April 16, 2014
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM