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Protein

Microtubule-associated serine/threonine-protein kinase 1

Gene

MAST1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei403ATPPROSITE-ProRule annotationBy similarity1
Active sitei497Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi380 – 388ATPPROSITE-ProRule annotationBy similarity9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS02773-MONOMER.
SignaLinkiQ9Y2H9.
SIGNORiQ9Y2H9.

Names & Taxonomyi

Protein namesi
Recommended name:
Microtubule-associated serine/threonine-protein kinase 1 (EC:2.7.11.1)
Alternative name(s):
Syntrophin-associated serine/threonine-protein kinase
Gene namesi
Name:MAST1Imported
Synonyms:KIAA0973Imported, SAST
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:19034. MAST1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000105613.
PharmGKBiPA134946727.

Chemistry databases

ChEMBLiCHEMBL1163128.
GuidetoPHARMACOLOGYi1510.

Polymorphism and mutation databases

BioMutaiMAST1.
DMDMi60390226.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000863091 – 1570Microtubule-associated serine/threonine-protein kinase 1Add BLAST1570

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei90PhosphoserineBy similarity1
Modified residuei139PhosphoserineBy similarity1
Modified residuei167PhosphoserineBy similarity1
Modified residuei346PhosphoserineBy similarity1
Modified residuei351PhosphothreonineBy similarity1
Modified residuei687PhosphoserineBy similarity1
Modified residuei893PhosphoserineBy similarity1
Modified residuei952PhosphoserineBy similarity1
Modified residuei1413PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y2H9.
MaxQBiQ9Y2H9.
PaxDbiQ9Y2H9.
PeptideAtlasiQ9Y2H9.
PRIDEiQ9Y2H9.

PTM databases

iPTMnetiQ9Y2H9.
PhosphoSitePlusiQ9Y2H9.

Expressioni

Gene expression databases

BgeeiENSG00000105613.
CleanExiHS_MAST1.
ExpressionAtlasiQ9Y2H9. baseline and differential.
GenevisibleiQ9Y2H9. HS.

Organism-specific databases

HPAiHPA028181.

Interactioni

Subunit structurei

Part of a low affinity complex that associates with, but is distinct from, the postsynaptic density. Interacts with SNTB2 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
EGFRP005332EBI-3385920,EBI-297353

Protein-protein interaction databases

BioGridi116632. 39 interactors.
IntActiQ9Y2H9. 36 interactors.
STRINGi9606.ENSP00000251472.

Chemistry databases

BindingDBiQ9Y2H9.

Structurei

Secondary structure

11570
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi189 – 202Combined sources14
Helixi216 – 237Combined sources22
Helixi242 – 261Combined sources20
Helixi268 – 281Combined sources14
Beta strandi968 – 971Combined sources4
Beta strandi973 – 975Combined sources3
Beta strandi978 – 987Combined sources10
Beta strandi994 – 1003Combined sources10
Helixi1008 – 1012Combined sources5
Beta strandi1019 – 1023Combined sources5
Helixi1033 – 1042Combined sources10
Turni1043 – 1045Combined sources3
Beta strandi1046 – 1052Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2M9XNMR-A187-287[»]
3PS4X-ray1.85A/B/C/D965-1057[»]
ProteinModelPortaliQ9Y2H9.
SMRiQ9Y2H9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y2H9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini374 – 647Protein kinasePROSITE-ProRule annotationAdd BLAST274
Domaini648 – 719AGC-kinase C-terminalAdd BLAST72
Domaini967 – 1055PDZPROSITE-ProRule annotationAdd BLAST89

Sequence similaritiesi

Contains 1 AGC-kinase C-terminal domain.Curated
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0606. Eukaryota.
ENOG410XPWX. LUCA.
GeneTreeiENSGT00530000063286.
HOGENOMiHOG000046662.
HOVERGENiHBG052414.
InParanoidiQ9Y2H9.
KOiK08789.
OMAiGCTRHQS.
OrthoDBiEOG091G00IH.
PhylomeDBiQ9Y2H9.
TreeFamiTF313149.

Family and domain databases

Gene3Di1.20.1480.20. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR015022. MA_Ser/Thr_Kinase_dom.
IPR028777. MAST1.
IPR023142. MAST_pre-PK_dom.
IPR001478. PDZ.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR24356:SF150. PTHR24356:SF150. 2 hits.
PfamiPF08926. DUF1908. 1 hit.
PF00595. PDZ. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF140482. SSF140482. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS50106. PDZ. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y2H9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDSLWTALS NFSMPSFPGG SMFRRTKSCR TSNRKSLILT STSPTLPRPH
60 70 80 90 100
SPLPGHLGSS PLDSPRNFSP NTPAHFSFAS SRRADGRRWS LASLPSSGYG
110 120 130 140 150
TNTPSSTVSS SCSSQERLHQ LPYQPTVDEL HFLSKHFGST ESITDEDGGR
160 170 180 190 200
RSPAVRPRSR SLSPGRSPSS YDNEIVMMNH VYKERFPKAT AQMEEKLRDF
210 220 230 240 250
TRAYEPDSVL PLADGVLSFI HHQIIELARD CLTKSRDGLI TTVYFYELQE
260 270 280 290 300
NLEKLLQDAY ERSESLEVAF VTQLVKKLLI IISRPARLLE CLEFNPEEFY
310 320 330 340 350
HLLEAAEGHA KEGHLVKTDI PRYIIRQLGL TRDPFPDVVH LEEQDSGGSN
360 370 380 390 400
TPEQDDLSEG RSSKAKKPPG ENDFDTIKLI SNGAYGAVYL VRHRDTRQRF
410 420 430 440 450
AMKKINKQNL ILRNQIQQAF VERDILTFAE NPFVVGMFCS FETRRHLCMV
460 470 480 490 500
MEYVEGGDCA TLLKNIGALP VEMARMYFAE TVLALEYLHN YGIVHRDLKP
510 520 530 540 550
DNLLITSMGH IKLTDFGLSK MGLMSLTTNL YEGHIEKDAR EFLDKQVCGT
560 570 580 590 600
PEYIAPEVIL RQGYGKPVDW WAMGIILYEF LVGCVPFFGD TPEELFGQVI
610 620 630 640 650
SDDILWPEGD EALPTEAQLL ISSLLQTNPL VRLGAGGAFE VKQHSFFRDL
660 670 680 690 700
DWTGLLRQKA EFIPHLESED DTSYFDTRSD RYHHVNSYDE DDTTEEEPVE
710 720 730 740 750
IRQFSSCSPR FSKVYSSMEQ LSQHEPKTPV AAAGSSKREP STKGPEEKVA
760 770 780 790 800
GKREGLGGLT LREKTWRGGS PEIKRFSASE ASFLEGEASP PLGARRRFSA
810 820 830 840 850
LLEPSRFSAP QEDEDEARLR RPPRPSSDPA GSLDARAPKE ETQGEGTSSA
860 870 880 890 900
GDSEATDRPR PGDLCPPSKD GDASGPRATN DLVLRRARHQ QMSGDVAVEK
910 920 930 940 950
RPSRTGGKVI KSASATALSV MIPAVDPHGS SPLASPMSPR SLSSNPSSRD
960 970 980 990 1000
SSPSRDYSPA VSGLRSPITI QRSGKKYGFT LRAIRVYMGD TDVYSVHHIV
1010 1020 1030 1040 1050
WHVEEGGPAQ EAGLCAGDLI THVNGEPVHG MVHPEVVELI LKSGNKVAVT
1060 1070 1080 1090 1100
TTPFENTSIR IGPARRSSYK AKMARRNKRP SAKEGQESKK RSSLFRKITK
1110 1120 1130 1140 1150
QSNLLHTSRS LSSLNRSLSS SDSLPGSPTH GLPARSPTHS YRSTPDSAYL
1160 1170 1180 1190 1200
GASSQSSSPA SSTPNSPASS ASHHIRPSTL HGLSPKLHRQ YRSARCKSAG
1210 1220 1230 1240 1250
NIPLSPLAHT PSPTQASPPP LPGHTVGSSH TTQSFPAKLH SSPPVVRPRP
1260 1270 1280 1290 1300
KSAEPPRSPL LKRVQSAEKL GASLSADKKG ALRKHSLEVG HPDFRKDFHG
1310 1320 1330 1340 1350
ELALHSLAES DGETPPVEGL GAPRQVAVRR LGRQESPLSL GADPLLPEGA
1360 1370 1380 1390 1400
SRPPVSSKEK ESPGGAEACT PPRATTPGGR TLERDVGCTR HQSVQTEDGT
1410 1420 1430 1440 1450
GGMARAVAKA ALSPVQEHET GRRSSSGEAG TPLVPIVVEP ARPGAKAVVP
1460 1470 1480 1490 1500
QPLGADSKGL QEPAPLAPSV PEAPRGRERW VLEVVEERTT LSGPRSKPAS
1510 1520 1530 1540 1550
PKLSPEPQTP SLAPAKCSAP SSAVTPVPPA SLLGSGTKPQ VGLTSRCPAE
1560 1570
AVPPAGLTKK GVSSPAPPGP
Length:1,570
Mass (Da):170,677
Last modified:March 1, 2005 - v2
Checksum:i189D24AE07B62A1E
GO

Sequence cautioni

The sequence AAB51171 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAH27985 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA76817 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_040768269A → T in a metastatic melanoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_0516441048A → S.Corresponds to variant rs35052801dbSNPEnsembl.1
Natural variantiVAR_0407691240H → Y in an ovarian serous carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_0407701292P → S.1 PublicationCorresponds to variant rs35071862dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023190 mRNA. Translation: BAA76817.1. Different initiation.
AC020934 Genomic DNA. No translation available.
AD000092 Genomic DNA. Translation: AAB51171.1. Sequence problems.
BC027985 mRNA. Translation: AAH27985.2. Different initiation.
CCDSiCCDS32921.1.
PIRiT45070.
RefSeqiNP_055790.1. NM_014975.2.
UniGeneiHs.227489.

Genome annotation databases

EnsembliENST00000251472; ENSP00000251472; ENSG00000105613.
GeneIDi22983.
KEGGihsa:22983.
UCSCiuc002mvm.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023190 mRNA. Translation: BAA76817.1. Different initiation.
AC020934 Genomic DNA. No translation available.
AD000092 Genomic DNA. Translation: AAB51171.1. Sequence problems.
BC027985 mRNA. Translation: AAH27985.2. Different initiation.
CCDSiCCDS32921.1.
PIRiT45070.
RefSeqiNP_055790.1. NM_014975.2.
UniGeneiHs.227489.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2M9XNMR-A187-287[»]
3PS4X-ray1.85A/B/C/D965-1057[»]
ProteinModelPortaliQ9Y2H9.
SMRiQ9Y2H9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116632. 39 interactors.
IntActiQ9Y2H9. 36 interactors.
STRINGi9606.ENSP00000251472.

Chemistry databases

BindingDBiQ9Y2H9.
ChEMBLiCHEMBL1163128.
GuidetoPHARMACOLOGYi1510.

PTM databases

iPTMnetiQ9Y2H9.
PhosphoSitePlusiQ9Y2H9.

Polymorphism and mutation databases

BioMutaiMAST1.
DMDMi60390226.

Proteomic databases

EPDiQ9Y2H9.
MaxQBiQ9Y2H9.
PaxDbiQ9Y2H9.
PeptideAtlasiQ9Y2H9.
PRIDEiQ9Y2H9.

Protocols and materials databases

DNASUi22983.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000251472; ENSP00000251472; ENSG00000105613.
GeneIDi22983.
KEGGihsa:22983.
UCSCiuc002mvm.4. human.

Organism-specific databases

CTDi22983.
GeneCardsiMAST1.
HGNCiHGNC:19034. MAST1.
HPAiHPA028181.
MIMi612256. gene.
neXtProtiNX_Q9Y2H9.
OpenTargetsiENSG00000105613.
PharmGKBiPA134946727.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0606. Eukaryota.
ENOG410XPWX. LUCA.
GeneTreeiENSGT00530000063286.
HOGENOMiHOG000046662.
HOVERGENiHBG052414.
InParanoidiQ9Y2H9.
KOiK08789.
OMAiGCTRHQS.
OrthoDBiEOG091G00IH.
PhylomeDBiQ9Y2H9.
TreeFamiTF313149.

Enzyme and pathway databases

BioCyciZFISH:HS02773-MONOMER.
SignaLinkiQ9Y2H9.
SIGNORiQ9Y2H9.

Miscellaneous databases

ChiTaRSiMAST1. human.
EvolutionaryTraceiQ9Y2H9.
GeneWikiiMAST1.
GenomeRNAii22983.
PROiQ9Y2H9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105613.
CleanExiHS_MAST1.
ExpressionAtlasiQ9Y2H9. baseline and differential.
GenevisibleiQ9Y2H9. HS.

Family and domain databases

Gene3Di1.20.1480.20. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR015022. MA_Ser/Thr_Kinase_dom.
IPR028777. MAST1.
IPR023142. MAST_pre-PK_dom.
IPR001478. PDZ.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR24356:SF150. PTHR24356:SF150. 2 hits.
PfamiPF08926. DUF1908. 1 hit.
PF00595. PDZ. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF140482. SSF140482. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS50106. PDZ. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMAST1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2H9
Secondary accession number(s): O00114, Q8N6X0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: November 2, 2016
This is version 148 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.