Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Microtubule-associated serine/threonine-protein kinase 1

Gene

MAST1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei403ATPPROSITE-ProRule annotationBy similarity1
Active sitei497Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi380 – 388ATPPROSITE-ProRule annotationBy similarity9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ9Y2H9
SIGNORiQ9Y2H9

Names & Taxonomyi

Protein namesi
Recommended name:
Microtubule-associated serine/threonine-protein kinase 1 (EC:2.7.11.1)
Alternative name(s):
Syntrophin-associated serine/threonine-protein kinase
Gene namesi
Name:MAST1Imported
Synonyms:KIAA0973Imported, SAST
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105613.9
HGNCiHGNC:19034 MAST1
MIMi612256 gene
neXtProtiNX_Q9Y2H9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000105613
PharmGKBiPA134946727

Chemistry databases

ChEMBLiCHEMBL1163128
GuidetoPHARMACOLOGYi1510

Polymorphism and mutation databases

BioMutaiMAST1
DMDMi60390226

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000863091 – 1570Microtubule-associated serine/threonine-protein kinase 1Add BLAST1570

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei90PhosphoserineBy similarity1
Modified residuei139PhosphoserineBy similarity1
Modified residuei167PhosphoserineBy similarity1
Modified residuei346PhosphoserineBy similarity1
Modified residuei351PhosphothreonineBy similarity1
Modified residuei687PhosphoserineBy similarity1
Modified residuei893PhosphoserineBy similarity1
Modified residuei952PhosphoserineBy similarity1
Modified residuei1413PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9Y2H9
PaxDbiQ9Y2H9
PeptideAtlasiQ9Y2H9
PRIDEiQ9Y2H9

PTM databases

iPTMnetiQ9Y2H9
PhosphoSitePlusiQ9Y2H9

Expressioni

Gene expression databases

BgeeiENSG00000105613
CleanExiHS_MAST1
ExpressionAtlasiQ9Y2H9 baseline and differential
GenevisibleiQ9Y2H9 HS

Organism-specific databases

HPAiHPA028181

Interactioni

Subunit structurei

Part of a low affinity complex that associates with, but is distinct from, the postsynaptic density. Interacts with SNTB2 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
EGFRP005332EBI-3385920,EBI-297353

Protein-protein interaction databases

BioGridi116632, 39 interactors
IntActiQ9Y2H9, 36 interactors
STRINGi9606.ENSP00000251472

Chemistry databases

BindingDBiQ9Y2H9

Structurei

Secondary structure

11570
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi189 – 202Combined sources14
Helixi216 – 237Combined sources22
Helixi242 – 261Combined sources20
Helixi268 – 281Combined sources14
Beta strandi968 – 971Combined sources4
Beta strandi973 – 975Combined sources3
Beta strandi978 – 987Combined sources10
Beta strandi994 – 1003Combined sources10
Helixi1008 – 1012Combined sources5
Beta strandi1019 – 1023Combined sources5
Helixi1033 – 1042Combined sources10
Turni1043 – 1045Combined sources3
Beta strandi1046 – 1052Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2M9XNMR-A187-287[»]
3PS4X-ray1.85A/B/C/D965-1057[»]
ProteinModelPortaliQ9Y2H9
SMRiQ9Y2H9
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y2H9

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini374 – 647Protein kinasePROSITE-ProRule annotationAdd BLAST274
Domaini648 – 719AGC-kinase C-terminalAdd BLAST72
Domaini967 – 1055PDZPROSITE-ProRule annotationAdd BLAST89

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0606 Eukaryota
ENOG410XPWX LUCA
GeneTreeiENSGT00530000063286
HOGENOMiHOG000046662
HOVERGENiHBG052414
InParanoidiQ9Y2H9
KOiK08789
OMAiRPGDLCP
OrthoDBiEOG091G00IH
PhylomeDBiQ9Y2H9
TreeFamiTF313149

Family and domain databases

CDDicd05609 STKc_MAST, 1 hit
Gene3Di1.20.1480.20, 1 hit
InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR011009 Kinase-like_dom_sf
IPR015022 MA_Ser/Thr_Kinase_dom
IPR037711 MAST
IPR028777 MAST1
IPR023142 MAST_pre-PK_dom_sf
IPR001478 PDZ
IPR036034 PDZ_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR24356:SF150 PTHR24356:SF150, 1 hit
PfamiView protein in Pfam
PF08926 DUF1908, 1 hit
PF00595 PDZ, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF140482 SSF140482, 1 hit
SSF50156 SSF50156, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS50106 PDZ, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Y2H9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDSLWTALS NFSMPSFPGG SMFRRTKSCR TSNRKSLILT STSPTLPRPH
60 70 80 90 100
SPLPGHLGSS PLDSPRNFSP NTPAHFSFAS SRRADGRRWS LASLPSSGYG
110 120 130 140 150
TNTPSSTVSS SCSSQERLHQ LPYQPTVDEL HFLSKHFGST ESITDEDGGR
160 170 180 190 200
RSPAVRPRSR SLSPGRSPSS YDNEIVMMNH VYKERFPKAT AQMEEKLRDF
210 220 230 240 250
TRAYEPDSVL PLADGVLSFI HHQIIELARD CLTKSRDGLI TTVYFYELQE
260 270 280 290 300
NLEKLLQDAY ERSESLEVAF VTQLVKKLLI IISRPARLLE CLEFNPEEFY
310 320 330 340 350
HLLEAAEGHA KEGHLVKTDI PRYIIRQLGL TRDPFPDVVH LEEQDSGGSN
360 370 380 390 400
TPEQDDLSEG RSSKAKKPPG ENDFDTIKLI SNGAYGAVYL VRHRDTRQRF
410 420 430 440 450
AMKKINKQNL ILRNQIQQAF VERDILTFAE NPFVVGMFCS FETRRHLCMV
460 470 480 490 500
MEYVEGGDCA TLLKNIGALP VEMARMYFAE TVLALEYLHN YGIVHRDLKP
510 520 530 540 550
DNLLITSMGH IKLTDFGLSK MGLMSLTTNL YEGHIEKDAR EFLDKQVCGT
560 570 580 590 600
PEYIAPEVIL RQGYGKPVDW WAMGIILYEF LVGCVPFFGD TPEELFGQVI
610 620 630 640 650
SDDILWPEGD EALPTEAQLL ISSLLQTNPL VRLGAGGAFE VKQHSFFRDL
660 670 680 690 700
DWTGLLRQKA EFIPHLESED DTSYFDTRSD RYHHVNSYDE DDTTEEEPVE
710 720 730 740 750
IRQFSSCSPR FSKVYSSMEQ LSQHEPKTPV AAAGSSKREP STKGPEEKVA
760 770 780 790 800
GKREGLGGLT LREKTWRGGS PEIKRFSASE ASFLEGEASP PLGARRRFSA
810 820 830 840 850
LLEPSRFSAP QEDEDEARLR RPPRPSSDPA GSLDARAPKE ETQGEGTSSA
860 870 880 890 900
GDSEATDRPR PGDLCPPSKD GDASGPRATN DLVLRRARHQ QMSGDVAVEK
910 920 930 940 950
RPSRTGGKVI KSASATALSV MIPAVDPHGS SPLASPMSPR SLSSNPSSRD
960 970 980 990 1000
SSPSRDYSPA VSGLRSPITI QRSGKKYGFT LRAIRVYMGD TDVYSVHHIV
1010 1020 1030 1040 1050
WHVEEGGPAQ EAGLCAGDLI THVNGEPVHG MVHPEVVELI LKSGNKVAVT
1060 1070 1080 1090 1100
TTPFENTSIR IGPARRSSYK AKMARRNKRP SAKEGQESKK RSSLFRKITK
1110 1120 1130 1140 1150
QSNLLHTSRS LSSLNRSLSS SDSLPGSPTH GLPARSPTHS YRSTPDSAYL
1160 1170 1180 1190 1200
GASSQSSSPA SSTPNSPASS ASHHIRPSTL HGLSPKLHRQ YRSARCKSAG
1210 1220 1230 1240 1250
NIPLSPLAHT PSPTQASPPP LPGHTVGSSH TTQSFPAKLH SSPPVVRPRP
1260 1270 1280 1290 1300
KSAEPPRSPL LKRVQSAEKL GASLSADKKG ALRKHSLEVG HPDFRKDFHG
1310 1320 1330 1340 1350
ELALHSLAES DGETPPVEGL GAPRQVAVRR LGRQESPLSL GADPLLPEGA
1360 1370 1380 1390 1400
SRPPVSSKEK ESPGGAEACT PPRATTPGGR TLERDVGCTR HQSVQTEDGT
1410 1420 1430 1440 1450
GGMARAVAKA ALSPVQEHET GRRSSSGEAG TPLVPIVVEP ARPGAKAVVP
1460 1470 1480 1490 1500
QPLGADSKGL QEPAPLAPSV PEAPRGRERW VLEVVEERTT LSGPRSKPAS
1510 1520 1530 1540 1550
PKLSPEPQTP SLAPAKCSAP SSAVTPVPPA SLLGSGTKPQ VGLTSRCPAE
1560 1570
AVPPAGLTKK GVSSPAPPGP
Length:1,570
Mass (Da):170,677
Last modified:March 1, 2005 - v2
Checksum:i189D24AE07B62A1E
GO

Sequence cautioni

The sequence AAB51171 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAH27985 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA76817 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_040768269A → T in a metastatic melanoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_0516441048A → S. Corresponds to variant dbSNP:rs35052801Ensembl.1
Natural variantiVAR_0407691240H → Y in an ovarian serous carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_0407701292P → S1 PublicationCorresponds to variant dbSNP:rs35071862Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023190 mRNA Translation: BAA76817.1 Different initiation.
AC020934 Genomic DNA No translation available.
AD000092 Genomic DNA Translation: AAB51171.1 Sequence problems.
BC027985 mRNA Translation: AAH27985.2 Different initiation.
CCDSiCCDS32921.1
PIRiT45070
RefSeqiNP_055790.1, NM_014975.2
UniGeneiHs.227489

Genome annotation databases

EnsembliENST00000251472; ENSP00000251472; ENSG00000105613
GeneIDi22983
KEGGihsa:22983
UCSCiuc002mvm.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMAST1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2H9
Secondary accession number(s): O00114, Q8N6X0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: February 28, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health