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Q9Y2H9

- MAST1_HUMAN

UniProt

Q9Y2H9 - MAST1_HUMAN

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Protein

Microtubule-associated serine/threonine-protein kinase 1

Gene

MAST1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei403 – 4031ATPBy similarityPROSITE-ProRule annotation
Active sitei497 – 4971Proton acceptorBy similarityPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi380 – 3889ATPBy similarityPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB
  2. magnesium ion binding Source: UniProtKB
  3. protein serine/threonine kinase activity Source: UniProtKB

GO - Biological processi

  1. cytoskeleton organization Source: UniProtKB
  2. intracellular signal transduction Source: UniProtKB
  3. protein phosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ9Y2H9.

Names & Taxonomyi

Protein namesi
Recommended name:
Microtubule-associated serine/threonine-protein kinase 1 (EC:2.7.11.1)
Alternative name(s):
Syntrophin-associated serine/threonine-protein kinase
Gene namesi
Name:MAST1Imported
Synonyms:KIAA0973Imported, SAST
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:19034. MAST1.

Subcellular locationi

Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Cytoplasmcytoskeleton By similarity
Note: Colocalizes with syntrophins at the cell membrane.By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. cytoskeleton Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134946727.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15701570Microtubule-associated serine/threonine-protein kinase 1PRO_0000086309Add
BLAST

Proteomic databases

MaxQBiQ9Y2H9.
PaxDbiQ9Y2H9.
PeptideAtlasiQ9Y2H9.
PRIDEiQ9Y2H9.

PTM databases

PhosphoSiteiQ9Y2H9.

Expressioni

Gene expression databases

BgeeiQ9Y2H9.
CleanExiHS_MAST1.
ExpressionAtlasiQ9Y2H9. baseline and differential.
GenevestigatoriQ9Y2H9.

Organism-specific databases

HPAiHPA028181.

Interactioni

Subunit structurei

Part of a low affinity complex that associates with, but is distinct from, the postsynaptic density. Interacts with SNTB2 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
EGFRP005332EBI-3385920,EBI-297353

Protein-protein interaction databases

BioGridi116632. 36 interactions.
IntActiQ9Y2H9. 32 interactions.
STRINGi9606.ENSP00000251472.

Structurei

Secondary structure

1
1570
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi189 – 20214Combined sources
Helixi216 – 23722Combined sources
Helixi242 – 26120Combined sources
Helixi268 – 28114Combined sources
Beta strandi968 – 9714Combined sources
Beta strandi973 – 9753Combined sources
Beta strandi978 – 98710Combined sources
Beta strandi994 – 100310Combined sources
Helixi1008 – 10125Combined sources
Beta strandi1019 – 10235Combined sources
Helixi1033 – 104210Combined sources
Turni1043 – 10453Combined sources
Beta strandi1046 – 10527Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2M9XNMR-A187-287[»]
3PS4X-ray1.85A/B/C/D965-1057[»]
ProteinModelPortaliQ9Y2H9.
SMRiQ9Y2H9. Positions 187-287, 314-724, 965-1057.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y2H9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini374 – 647274Protein kinasePROSITE-ProRule annotationAdd
BLAST
Domaini648 – 71972AGC-kinase C-terminalAdd
BLAST
Domaini967 – 105589PDZPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 AGC-kinase C-terminal domain.Curated
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00530000063286.
HOGENOMiHOG000046662.
HOVERGENiHBG052414.
InParanoidiQ9Y2H9.
KOiK08789.
OMAiGCTRHQS.
OrthoDBiEOG7PK8ZC.
PhylomeDBiQ9Y2H9.
TreeFamiTF313149.

Family and domain databases

Gene3Di1.20.1480.20. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR015022. MA_Ser/Thr_Kinase_dom.
IPR028777. MAST1.
IPR023142. MAST_pre-PK_dom.
IPR001478. PDZ.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR24356:SF150. PTHR24356:SF150. 1 hit.
PfamiPF08926. DUF1908. 1 hit.
PF00595. PDZ. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF140482. SSF140482. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS50106. PDZ. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y2H9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDSLWTALS NFSMPSFPGG SMFRRTKSCR TSNRKSLILT STSPTLPRPH
60 70 80 90 100
SPLPGHLGSS PLDSPRNFSP NTPAHFSFAS SRRADGRRWS LASLPSSGYG
110 120 130 140 150
TNTPSSTVSS SCSSQERLHQ LPYQPTVDEL HFLSKHFGST ESITDEDGGR
160 170 180 190 200
RSPAVRPRSR SLSPGRSPSS YDNEIVMMNH VYKERFPKAT AQMEEKLRDF
210 220 230 240 250
TRAYEPDSVL PLADGVLSFI HHQIIELARD CLTKSRDGLI TTVYFYELQE
260 270 280 290 300
NLEKLLQDAY ERSESLEVAF VTQLVKKLLI IISRPARLLE CLEFNPEEFY
310 320 330 340 350
HLLEAAEGHA KEGHLVKTDI PRYIIRQLGL TRDPFPDVVH LEEQDSGGSN
360 370 380 390 400
TPEQDDLSEG RSSKAKKPPG ENDFDTIKLI SNGAYGAVYL VRHRDTRQRF
410 420 430 440 450
AMKKINKQNL ILRNQIQQAF VERDILTFAE NPFVVGMFCS FETRRHLCMV
460 470 480 490 500
MEYVEGGDCA TLLKNIGALP VEMARMYFAE TVLALEYLHN YGIVHRDLKP
510 520 530 540 550
DNLLITSMGH IKLTDFGLSK MGLMSLTTNL YEGHIEKDAR EFLDKQVCGT
560 570 580 590 600
PEYIAPEVIL RQGYGKPVDW WAMGIILYEF LVGCVPFFGD TPEELFGQVI
610 620 630 640 650
SDDILWPEGD EALPTEAQLL ISSLLQTNPL VRLGAGGAFE VKQHSFFRDL
660 670 680 690 700
DWTGLLRQKA EFIPHLESED DTSYFDTRSD RYHHVNSYDE DDTTEEEPVE
710 720 730 740 750
IRQFSSCSPR FSKVYSSMEQ LSQHEPKTPV AAAGSSKREP STKGPEEKVA
760 770 780 790 800
GKREGLGGLT LREKTWRGGS PEIKRFSASE ASFLEGEASP PLGARRRFSA
810 820 830 840 850
LLEPSRFSAP QEDEDEARLR RPPRPSSDPA GSLDARAPKE ETQGEGTSSA
860 870 880 890 900
GDSEATDRPR PGDLCPPSKD GDASGPRATN DLVLRRARHQ QMSGDVAVEK
910 920 930 940 950
RPSRTGGKVI KSASATALSV MIPAVDPHGS SPLASPMSPR SLSSNPSSRD
960 970 980 990 1000
SSPSRDYSPA VSGLRSPITI QRSGKKYGFT LRAIRVYMGD TDVYSVHHIV
1010 1020 1030 1040 1050
WHVEEGGPAQ EAGLCAGDLI THVNGEPVHG MVHPEVVELI LKSGNKVAVT
1060 1070 1080 1090 1100
TTPFENTSIR IGPARRSSYK AKMARRNKRP SAKEGQESKK RSSLFRKITK
1110 1120 1130 1140 1150
QSNLLHTSRS LSSLNRSLSS SDSLPGSPTH GLPARSPTHS YRSTPDSAYL
1160 1170 1180 1190 1200
GASSQSSSPA SSTPNSPASS ASHHIRPSTL HGLSPKLHRQ YRSARCKSAG
1210 1220 1230 1240 1250
NIPLSPLAHT PSPTQASPPP LPGHTVGSSH TTQSFPAKLH SSPPVVRPRP
1260 1270 1280 1290 1300
KSAEPPRSPL LKRVQSAEKL GASLSADKKG ALRKHSLEVG HPDFRKDFHG
1310 1320 1330 1340 1350
ELALHSLAES DGETPPVEGL GAPRQVAVRR LGRQESPLSL GADPLLPEGA
1360 1370 1380 1390 1400
SRPPVSSKEK ESPGGAEACT PPRATTPGGR TLERDVGCTR HQSVQTEDGT
1410 1420 1430 1440 1450
GGMARAVAKA ALSPVQEHET GRRSSSGEAG TPLVPIVVEP ARPGAKAVVP
1460 1470 1480 1490 1500
QPLGADSKGL QEPAPLAPSV PEAPRGRERW VLEVVEERTT LSGPRSKPAS
1510 1520 1530 1540 1550
PKLSPEPQTP SLAPAKCSAP SSAVTPVPPA SLLGSGTKPQ VGLTSRCPAE
1560 1570
AVPPAGLTKK GVSSPAPPGP
Length:1,570
Mass (Da):170,677
Last modified:March 1, 2005 - v2
Checksum:i189D24AE07B62A1E
GO

Sequence cautioni

The sequence AAB51171.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence AAH27985.2 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAA76817.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti269 – 2691A → T in a metastatic melanoma sample; somatic mutation. 1 Publication
VAR_040768
Natural varianti1048 – 10481A → S.
Corresponds to variant rs35052801 [ dbSNP | Ensembl ].
VAR_051644
Natural varianti1240 – 12401H → Y in an ovarian serous carcinoma sample; somatic mutation. 1 Publication
VAR_040769
Natural varianti1292 – 12921P → S.1 Publication
Corresponds to variant rs35071862 [ dbSNP | Ensembl ].
VAR_040770

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023190 mRNA. Translation: BAA76817.1. Different initiation.
AC020934 Genomic DNA. No translation available.
AD000092 Genomic DNA. Translation: AAB51171.1. Sequence problems.
BC027985 mRNA. Translation: AAH27985.2. Different initiation.
CCDSiCCDS32921.1.
PIRiT45070.
RefSeqiNP_055790.1. NM_014975.2.
UniGeneiHs.227489.

Genome annotation databases

EnsembliENST00000251472; ENSP00000251472; ENSG00000105613.
GeneIDi22983.
KEGGihsa:22983.
UCSCiuc002mvm.3. human.

Polymorphism databases

DMDMi60390226.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023190 mRNA. Translation: BAA76817.1 . Different initiation.
AC020934 Genomic DNA. No translation available.
AD000092 Genomic DNA. Translation: AAB51171.1 . Sequence problems.
BC027985 mRNA. Translation: AAH27985.2 . Different initiation.
CCDSi CCDS32921.1.
PIRi T45070.
RefSeqi NP_055790.1. NM_014975.2.
UniGenei Hs.227489.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2M9X NMR - A 187-287 [» ]
3PS4 X-ray 1.85 A/B/C/D 965-1057 [» ]
ProteinModelPortali Q9Y2H9.
SMRi Q9Y2H9. Positions 187-287, 314-724, 965-1057.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116632. 36 interactions.
IntActi Q9Y2H9. 32 interactions.
STRINGi 9606.ENSP00000251472.

Chemistry

BindingDBi Q9Y2H9.
ChEMBLi CHEMBL3038500.
GuidetoPHARMACOLOGYi 1510.

PTM databases

PhosphoSitei Q9Y2H9.

Polymorphism databases

DMDMi 60390226.

Proteomic databases

MaxQBi Q9Y2H9.
PaxDbi Q9Y2H9.
PeptideAtlasi Q9Y2H9.
PRIDEi Q9Y2H9.

Protocols and materials databases

DNASUi 22983.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000251472 ; ENSP00000251472 ; ENSG00000105613 .
GeneIDi 22983.
KEGGi hsa:22983.
UCSCi uc002mvm.3. human.

Organism-specific databases

CTDi 22983.
GeneCardsi GC19P012949.
HGNCi HGNC:19034. MAST1.
HPAi HPA028181.
MIMi 612256. gene.
neXtProti NX_Q9Y2H9.
PharmGKBi PA134946727.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00530000063286.
HOGENOMi HOG000046662.
HOVERGENi HBG052414.
InParanoidi Q9Y2H9.
KOi K08789.
OMAi GCTRHQS.
OrthoDBi EOG7PK8ZC.
PhylomeDBi Q9Y2H9.
TreeFami TF313149.

Enzyme and pathway databases

SignaLinki Q9Y2H9.

Miscellaneous databases

ChiTaRSi MAST1. human.
EvolutionaryTracei Q9Y2H9.
GeneWikii MAST1.
GenomeRNAii 22983.
NextBioi 43815.
PROi Q9Y2H9.
SOURCEi Search...

Gene expression databases

Bgeei Q9Y2H9.
CleanExi HS_MAST1.
ExpressionAtlasi Q9Y2H9. baseline and differential.
Genevestigatori Q9Y2H9.

Family and domain databases

Gene3Di 1.20.1480.20. 1 hit.
2.30.42.10. 1 hit.
InterProi IPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR015022. MA_Ser/Thr_Kinase_dom.
IPR028777. MAST1.
IPR023142. MAST_pre-PK_dom.
IPR001478. PDZ.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
PANTHERi PTHR24356:SF150. PTHR24356:SF150. 1 hit.
Pfami PF08926. DUF1908. 1 hit.
PF00595. PDZ. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00228. PDZ. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF140482. SSF140482. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS51285. AGC_KINASE_CTER. 1 hit.
PS50106. PDZ. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 390-1570.
    Tissue: Brain.
  4. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-269; TYR-1240 AND SER-1292.

Entry informationi

Entry nameiMAST1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2H9
Secondary accession number(s): O00114, Q8N6X0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: November 26, 2014
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3