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Q9Y2H9

- MAST1_HUMAN

UniProt

Q9Y2H9 - MAST1_HUMAN

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Protein
Microtubule-associated serine/threonine-protein kinase 1
Gene
MAST1, KIAA0973, SAST
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins By similarity.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Magnesium By similarity.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei403 – 4031ATP By similarityBy similarity
Active sitei497 – 4971Proton acceptor By similarityBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi380 – 3889ATP By similarityBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB
  2. magnesium ion binding Source: UniProtKB
  3. protein binding Source: IntAct
  4. protein serine/threonine kinase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. cytoskeleton organization Source: UniProtKB
  2. intracellular signal transduction Source: UniProtKB
  3. protein phosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ9Y2H9.

Names & Taxonomyi

Protein namesi
Recommended name:
Microtubule-associated serine/threonine-protein kinase 1 (EC:2.7.11.1)
Alternative name(s):
Syntrophin-associated serine/threonine-protein kinase
Gene namesi
Name:MAST1
Synonyms:KIAA0973, SAST
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:19034. MAST1.

Subcellular locationi

Cell membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cytoplasmcytoskeleton By similarity
Note: Colocalizes with syntrophins at the cell membrane By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. cytoskeleton Source: UniProtKB-SubCell
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134946727.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15701570Microtubule-associated serine/threonine-protein kinase 1
PRO_0000086309Add
BLAST

Proteomic databases

MaxQBiQ9Y2H9.
PaxDbiQ9Y2H9.
PeptideAtlasiQ9Y2H9.
PRIDEiQ9Y2H9.

PTM databases

PhosphoSiteiQ9Y2H9.

Expressioni

Gene expression databases

ArrayExpressiQ9Y2H9.
BgeeiQ9Y2H9.
CleanExiHS_MAST1.
GenevestigatoriQ9Y2H9.

Organism-specific databases

HPAiHPA028181.

Interactioni

Subunit structurei

Part of a low affinity complex that associates with, but is distinct from, the postsynaptic density. Interacts with SNTB2 By similarity.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
EGFRP005332EBI-3385920,EBI-297353

Protein-protein interaction databases

BioGridi116632. 36 interactions.
IntActiQ9Y2H9. 32 interactions.
STRINGi9606.ENSP00000251472.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi189 – 20214
Helixi216 – 23722
Helixi242 – 26120
Helixi268 – 28114
Beta strandi968 – 9714
Beta strandi973 – 9753
Beta strandi978 – 98710
Beta strandi994 – 100310
Helixi1008 – 10125
Beta strandi1019 – 10235
Helixi1033 – 104210
Turni1043 – 10453
Beta strandi1046 – 10527

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2M9XNMR-A187-287[»]
3PS4X-ray1.85A/B/C/D965-1057[»]
ProteinModelPortaliQ9Y2H9.
SMRiQ9Y2H9. Positions 187-713, 965-1057.

Miscellaneous databases

EvolutionaryTraceiQ9Y2H9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini374 – 647274Protein kinase
Add
BLAST
Domaini648 – 71972AGC-kinase C-terminal
Add
BLAST
Domaini967 – 105589PDZ
Add
BLAST

Sequence similaritiesi

Contains 1 PDZ (DHR) domain.

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000046662.
HOVERGENiHBG052414.
InParanoidiQ9Y2H9.
KOiK08789.
OMAiGCTRHQS.
OrthoDBiEOG7PK8ZC.
PhylomeDBiQ9Y2H9.
TreeFamiTF313149.

Family and domain databases

Gene3Di1.20.1480.20. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR015022. MA_Ser/Thr_Kinase_dom.
IPR028777. MAST1.
IPR023142. MAST_pre-PK_dom.
IPR001478. PDZ.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR24356:SF150. PTHR24356:SF150. 1 hit.
PfamiPF08926. DUF1908. 1 hit.
PF00595. PDZ. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF140482. SSF140482. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS50106. PDZ. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y2H9-1 [UniParc]FASTAAdd to Basket

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MSDSLWTALS NFSMPSFPGG SMFRRTKSCR TSNRKSLILT STSPTLPRPH     50
SPLPGHLGSS PLDSPRNFSP NTPAHFSFAS SRRADGRRWS LASLPSSGYG 100
TNTPSSTVSS SCSSQERLHQ LPYQPTVDEL HFLSKHFGST ESITDEDGGR 150
RSPAVRPRSR SLSPGRSPSS YDNEIVMMNH VYKERFPKAT AQMEEKLRDF 200
TRAYEPDSVL PLADGVLSFI HHQIIELARD CLTKSRDGLI TTVYFYELQE 250
NLEKLLQDAY ERSESLEVAF VTQLVKKLLI IISRPARLLE CLEFNPEEFY 300
HLLEAAEGHA KEGHLVKTDI PRYIIRQLGL TRDPFPDVVH LEEQDSGGSN 350
TPEQDDLSEG RSSKAKKPPG ENDFDTIKLI SNGAYGAVYL VRHRDTRQRF 400
AMKKINKQNL ILRNQIQQAF VERDILTFAE NPFVVGMFCS FETRRHLCMV 450
MEYVEGGDCA TLLKNIGALP VEMARMYFAE TVLALEYLHN YGIVHRDLKP 500
DNLLITSMGH IKLTDFGLSK MGLMSLTTNL YEGHIEKDAR EFLDKQVCGT 550
PEYIAPEVIL RQGYGKPVDW WAMGIILYEF LVGCVPFFGD TPEELFGQVI 600
SDDILWPEGD EALPTEAQLL ISSLLQTNPL VRLGAGGAFE VKQHSFFRDL 650
DWTGLLRQKA EFIPHLESED DTSYFDTRSD RYHHVNSYDE DDTTEEEPVE 700
IRQFSSCSPR FSKVYSSMEQ LSQHEPKTPV AAAGSSKREP STKGPEEKVA 750
GKREGLGGLT LREKTWRGGS PEIKRFSASE ASFLEGEASP PLGARRRFSA 800
LLEPSRFSAP QEDEDEARLR RPPRPSSDPA GSLDARAPKE ETQGEGTSSA 850
GDSEATDRPR PGDLCPPSKD GDASGPRATN DLVLRRARHQ QMSGDVAVEK 900
RPSRTGGKVI KSASATALSV MIPAVDPHGS SPLASPMSPR SLSSNPSSRD 950
SSPSRDYSPA VSGLRSPITI QRSGKKYGFT LRAIRVYMGD TDVYSVHHIV 1000
WHVEEGGPAQ EAGLCAGDLI THVNGEPVHG MVHPEVVELI LKSGNKVAVT 1050
TTPFENTSIR IGPARRSSYK AKMARRNKRP SAKEGQESKK RSSLFRKITK 1100
QSNLLHTSRS LSSLNRSLSS SDSLPGSPTH GLPARSPTHS YRSTPDSAYL 1150
GASSQSSSPA SSTPNSPASS ASHHIRPSTL HGLSPKLHRQ YRSARCKSAG 1200
NIPLSPLAHT PSPTQASPPP LPGHTVGSSH TTQSFPAKLH SSPPVVRPRP 1250
KSAEPPRSPL LKRVQSAEKL GASLSADKKG ALRKHSLEVG HPDFRKDFHG 1300
ELALHSLAES DGETPPVEGL GAPRQVAVRR LGRQESPLSL GADPLLPEGA 1350
SRPPVSSKEK ESPGGAEACT PPRATTPGGR TLERDVGCTR HQSVQTEDGT 1400
GGMARAVAKA ALSPVQEHET GRRSSSGEAG TPLVPIVVEP ARPGAKAVVP 1450
QPLGADSKGL QEPAPLAPSV PEAPRGRERW VLEVVEERTT LSGPRSKPAS 1500
PKLSPEPQTP SLAPAKCSAP SSAVTPVPPA SLLGSGTKPQ VGLTSRCPAE 1550
AVPPAGLTKK GVSSPAPPGP 1570
Length:1,570
Mass (Da):170,677
Last modified:March 1, 2005 - v2
Checksum:i189D24AE07B62A1E
GO

Sequence cautioni

The sequence AAH27985.2 differs from that shown. Reason: Erroneous initiation.
The sequence BAA76817.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAB51171.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti269 – 2691A → T in a metastatic melanoma sample; somatic mutation. 1 Publication
VAR_040768
Natural varianti1048 – 10481A → S.
Corresponds to variant rs35052801 [ dbSNP | Ensembl ].
VAR_051644
Natural varianti1240 – 12401H → Y in an ovarian serous carcinoma sample; somatic mutation. 1 Publication
VAR_040769
Natural varianti1292 – 12921P → S.1 Publication
Corresponds to variant rs35071862 [ dbSNP | Ensembl ].
VAR_040770

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB023190 mRNA. Translation: BAA76817.1. Different initiation.
AC020934 Genomic DNA. No translation available.
AD000092 Genomic DNA. Translation: AAB51171.1. Sequence problems.
BC027985 mRNA. Translation: AAH27985.2. Different initiation.
CCDSiCCDS32921.1.
PIRiT45070.
RefSeqiNP_055790.1. NM_014975.2.
UniGeneiHs.227489.

Genome annotation databases

EnsembliENST00000251472; ENSP00000251472; ENSG00000105613.
GeneIDi22983.
KEGGihsa:22983.
UCSCiuc002mvm.3. human.

Polymorphism databases

DMDMi60390226.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB023190 mRNA. Translation: BAA76817.1 . Different initiation.
AC020934 Genomic DNA. No translation available.
AD000092 Genomic DNA. Translation: AAB51171.1 . Sequence problems.
BC027985 mRNA. Translation: AAH27985.2 . Different initiation.
CCDSi CCDS32921.1.
PIRi T45070.
RefSeqi NP_055790.1. NM_014975.2.
UniGenei Hs.227489.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2M9X NMR - A 187-287 [» ]
3PS4 X-ray 1.85 A/B/C/D 965-1057 [» ]
ProteinModelPortali Q9Y2H9.
SMRi Q9Y2H9. Positions 187-713, 965-1057.
ModBasei Search...

Protein-protein interaction databases

BioGridi 116632. 36 interactions.
IntActi Q9Y2H9. 32 interactions.
STRINGi 9606.ENSP00000251472.

Chemistry

BindingDBi Q9Y2H9.
ChEMBLi CHEMBL3038500.
GuidetoPHARMACOLOGYi 1510.

PTM databases

PhosphoSitei Q9Y2H9.

Polymorphism databases

DMDMi 60390226.

Proteomic databases

MaxQBi Q9Y2H9.
PaxDbi Q9Y2H9.
PeptideAtlasi Q9Y2H9.
PRIDEi Q9Y2H9.

Protocols and materials databases

DNASUi 22983.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000251472 ; ENSP00000251472 ; ENSG00000105613 .
GeneIDi 22983.
KEGGi hsa:22983.
UCSCi uc002mvm.3. human.

Organism-specific databases

CTDi 22983.
GeneCardsi GC19P012949.
HGNCi HGNC:19034. MAST1.
HPAi HPA028181.
MIMi 612256. gene.
neXtProti NX_Q9Y2H9.
PharmGKBi PA134946727.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000046662.
HOVERGENi HBG052414.
InParanoidi Q9Y2H9.
KOi K08789.
OMAi GCTRHQS.
OrthoDBi EOG7PK8ZC.
PhylomeDBi Q9Y2H9.
TreeFami TF313149.

Enzyme and pathway databases

SignaLinki Q9Y2H9.

Miscellaneous databases

ChiTaRSi MAST1. human.
EvolutionaryTracei Q9Y2H9.
GeneWikii MAST1.
GenomeRNAii 22983.
NextBioi 43815.
PROi Q9Y2H9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9Y2H9.
Bgeei Q9Y2H9.
CleanExi HS_MAST1.
Genevestigatori Q9Y2H9.

Family and domain databases

Gene3Di 1.20.1480.20. 1 hit.
2.30.42.10. 1 hit.
InterProi IPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR015022. MA_Ser/Thr_Kinase_dom.
IPR028777. MAST1.
IPR023142. MAST_pre-PK_dom.
IPR001478. PDZ.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
PANTHERi PTHR24356:SF150. PTHR24356:SF150. 1 hit.
Pfami PF08926. DUF1908. 1 hit.
PF00595. PDZ. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00228. PDZ. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF140482. SSF140482. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS51285. AGC_KINASE_CTER. 1 hit.
PS50106. PDZ. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 390-1570.
    Tissue: Brain.
  4. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-269; TYR-1240 AND SER-1292.

Entry informationi

Entry nameiMAST1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2H9
Secondary accession number(s): O00114, Q8N6X0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: July 9, 2014
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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