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Protein

Zinc finger protein 510

Gene

ZNF510

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri254 – 276C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri404 – 426C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri432 – 454C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri460 – 482C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri488 – 510C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri516 – 538C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri544 – 566C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri572 – 594C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri600 – 622C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri628 – 650C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 510
Gene namesi
Name:ZNF510
Synonyms:KIAA0972
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000081386.12
HGNCiHGNC:29161 ZNF510
neXtProtiNX_Q9Y2H8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000081386
PharmGKBiPA134944603

Polymorphism and mutation databases

BioMutaiZNF510
DMDMi20178235

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476281 – 683Zinc finger protein 510Add BLAST683

Proteomic databases

EPDiQ9Y2H8
MaxQBiQ9Y2H8
PaxDbiQ9Y2H8
PeptideAtlasiQ9Y2H8
PRIDEiQ9Y2H8

PTM databases

iPTMnetiQ9Y2H8
PhosphoSitePlusiQ9Y2H8

Expressioni

Gene expression databases

BgeeiENSG00000081386
CleanExiHS_ZNF510
ExpressionAtlasiQ9Y2H8 baseline and differential
GenevisibleiQ9Y2H8 HS

Organism-specific databases

HPAiHPA049139

Interactioni

Protein-protein interaction databases

BioGridi116536, 2 interactors
IntActiQ9Y2H8, 23 interactors
MINTiQ9Y2H8
STRINGi9606.ENSP00000223428

Structurei

3D structure databases

ProteinModelPortaliQ9Y2H8
SMRiQ9Y2H8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 117KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri254 – 276C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri404 – 426C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri432 – 454C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri460 – 482C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri488 – 510C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri516 – 538C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri544 – 566C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri572 – 594C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri600 – 622C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri628 – 650C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00900000140826
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ9Y2H8
KOiK09228
OMAiSTKMSCK
OrthoDBiEOG091G02KC
PhylomeDBiQ9Y2H8
TreeFamiTF337898

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits

Sequencei

Sequence statusi: Complete.

Q9Y2H8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPHPEAITD CVTLNTVGQL AEGGYPLRFS TLFQEQQKMN ISQASVSFKD
60 70 80 90 100
VTIEFTQEEW QQMAPVQKNL YRDVMLENYS NLVSVGYCCF KPEVIFKLEQ
110 120 130 140 150
GEEPWFSEEE FSNQSHPKDY RGDDLIKQNK KIKDKHLEQA ICINNKTLTT
160 170 180 190 200
EEEKVLGKPF TLHVAAVAST KMSCKCNSWE VNLQSISEFI INNRNYSTKK
210 220 230 240 250
IGCGNVCENS PFKINFEKTQ TGEKFYEHNK NMKALNYNEN LPKHPKFQTL
260 270 280 290 300
EQAFECNKIG KAFNDKANCV KHNSSHTGET SSKDDEFRKN CDKKTLFDHR
310 320 330 340 350
RTGTGKKHLH LNQCGKSFEK STVEEYNKLN MGIKHYELNP SGNNFNRKAH
360 370 380 390 400
LTDPQTAVIE ENPLVSNDRT QTWVKSSEYH ENKKSYQTSV HRVRRRSHSM
410 420 430 440 450
MKPYKCNECG KSFCQKGHLI QHQRTHTGEK PFECSECGKT FSQKSHLSTH
460 470 480 490 500
QRIHTAEKPY KCNECGKTFV QKSTLRGHQR IHTGEKPYEC SECGKTFVQK
510 520 530 540 550
STLRDHHRIH TGEKSFQCNQ CGKTFGQKSN LRIHQRTHTG EKTYQCNECE
560 570 580 590 600
KSFWRKDHLI QHQKTHTGEK PFKCNECGKT FARTSTLRVH QRIHTGEKPF
610 620 630 640 650
KCNECGKKFV RKAILSDHQR IHTGEKPFQC NKCGKTFGQK SNLRIHQRTH
660 670 680
SGEKSYECNE YGKLCKKSTL SLYQKIQGEG NPY
Length:683
Mass (Da):79,142
Last modified:November 1, 1999 - v1
Checksum:iA87DB365993EE3F3
GO

Sequence cautioni

The sequence BAA76816 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01998243Q → R. Corresponds to variant dbSNP:rs2289651Ensembl.1
Natural variantiVAR_02189389C → R. Corresponds to variant dbSNP:rs3780548Ensembl.1
Natural variantiVAR_052848273N → K. Corresponds to variant dbSNP:rs10217154Ensembl.1
Natural variantiVAR_052849398H → D. Corresponds to variant dbSNP:rs11999094Ensembl.1
Natural variantiVAR_052850401M → I. Corresponds to variant dbSNP:rs10217494Ensembl.1
Natural variantiVAR_052851634G → E. Corresponds to variant dbSNP:rs10119874Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023189 mRNA Translation: BAA76816.2 Different initiation.
AK292600 mRNA Translation: BAF85289.1
AL589843 Genomic DNA No translation available.
CH471174 Genomic DNA Translation: EAW92666.1
BC058022 mRNA Translation: AAH58022.1 Different termination.
CCDSiCCDS35074.1
RefSeqiNP_001300988.1, NM_001314059.1
NP_055745.1, NM_014930.2
XP_016869972.1, XM_017014483.1
UniGeneiHs.633105
Hs.75264

Genome annotation databases

EnsembliENST00000223428; ENSP00000223428; ENSG00000081386
ENST00000375231; ENSP00000364379; ENSG00000081386
GeneIDi22869
KEGGihsa:22869
UCSCiuc004awn.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN510_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2H8
Secondary accession number(s): Q5SZP5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: November 1, 1999
Last modified: May 23, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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