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Protein

Fibronectin type-III domain-containing protein 3A

Gene

FNDC3A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates spermatid-Sertoli adhesion during spermatogenesis.By similarity

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Fibronectin type-III domain-containing protein 3A
Alternative name(s):
Human gene expressed in odontoblasts
Gene namesi
Name:FNDC3A
Synonyms:FNDC3, HUGO, KIAA0970
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:20296. FNDC3A.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1177 – 1197HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • acrosomal vesicle Source: Ensembl
  • cytosol Source: Ensembl
  • Golgi apparatus Source: UniProtKB
  • Golgi membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB
  • vesicle membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi22862.
OpenTargetsiENSG00000102531.
PharmGKBiPA128394588.

Polymorphism and mutation databases

BioMutaiFNDC3A.
DMDMi254763442.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000873211 – 1198Fibronectin type-III domain-containing protein 3AAdd BLAST1198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei203PhosphoserineCombined sources1
Modified residuei207PhosphoserineBy similarity1
Modified residuei213PhosphoserineCombined sources1
Modified residuei384N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9Y2H6.
PaxDbiQ9Y2H6.
PeptideAtlasiQ9Y2H6.
PRIDEiQ9Y2H6.

PTM databases

iPTMnetiQ9Y2H6.
PhosphoSitePlusiQ9Y2H6.
SwissPalmiQ9Y2H6.

Expressioni

Tissue specificityi

Expressed in the odontoblast and nerves in the dental pulp. Also expressed in trachea and to a lesser extent in the brain, liver, lung and kidney.1 Publication

Gene expression databases

BgeeiENSG00000102531.
CleanExiHS_FNDC3A.
ExpressionAtlasiQ9Y2H6. baseline and differential.
GenevisibleiQ9Y2H6. HS.

Organism-specific databases

HPAiHPA008927.
HPA012825.

Interactioni

Protein-protein interaction databases

BioGridi116530. 39 interactors.
IntActiQ9Y2H6. 25 interactors.
MINTiMINT-3084391.
STRINGi9606.ENSP00000417257.

Structurei

Secondary structure

11198
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi256 – 265Combined sources10
Beta strandi273 – 276Combined sources4
Beta strandi282 – 285Combined sources4
Beta strandi307 – 312Combined sources6
Beta strandi322 – 328Combined sources7
Beta strandi330 – 334Combined sources5
Beta strandi345 – 351Combined sources7
Beta strandi369 – 371Combined sources3
Beta strandi378 – 383Combined sources6
Beta strandi386 – 390Combined sources5
Beta strandi401 – 408Combined sources8
Turni410 – 412Combined sources3
Beta strandi413 – 415Combined sources3
Beta strandi418 – 424Combined sources7
Beta strandi426 – 432Combined sources7
Beta strandi438 – 442Combined sources5
Beta strandi445 – 449Combined sources5
Beta strandi458 – 461Combined sources4
Beta strandi474 – 478Combined sources5
Beta strandi480 – 486Combined sources7
Beta strandi495 – 498Combined sources4
Beta strandi500 – 505Combined sources6
Beta strandi508 – 511Combined sources4
Beta strandi515 – 521Combined sources7
Beta strandi523 – 529Combined sources7
Beta strandi535 – 543Combined sources9
Beta strandi548 – 551Combined sources4
Beta strandi555 – 558Combined sources4
Beta strandi571 – 577Combined sources7
Beta strandi580 – 584Combined sources5
Beta strandi598 – 609Combined sources12
Beta strandi613 – 616Combined sources4
Beta strandi621 – 625Combined sources5
Beta strandi634 – 642Combined sources9
Beta strandi676 – 682Combined sources7
Beta strandi696 – 702Combined sources7
Beta strandi710 – 716Combined sources7
Beta strandi718 – 724Combined sources7
Beta strandi730 – 733Combined sources4
Beta strandi736 – 738Combined sources3
Beta strandi750 – 753Combined sources4
Beta strandi768 – 771Combined sources4
Beta strandi774 – 778Combined sources5
Beta strandi785 – 787Combined sources3
Beta strandi791 – 799Combined sources9
Beta strandi805 – 810Combined sources6
Beta strandi812 – 818Combined sources7
Beta strandi824 – 832Combined sources9
Beta strandi844 – 847Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WK0NMR-A256-379[»]
1X3DNMR-A361-465[»]
1X4XNMR-A759-851[»]
1X5XNMR-A467-562[»]
2CRMNMR-A554-660[»]
2CRZNMR-A661-757[»]
ProteinModelPortaliQ9Y2H6.
SMRiQ9Y2H6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y2H6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini268 – 369Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST102
Domaini373 – 465Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST93
Domaini469 – 562Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST94
Domaini566 – 660Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST95
Domaini664 – 757Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST94
Domaini761 – 851Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST91
Domaini861 – 950Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST90
Domaini951 – 1045Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST95
Domaini1046 – 1151Fibronectin type-III 9PROSITE-ProRule annotationAdd BLAST106

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi68 – 133Pro-richAdd BLAST66

Sequence similaritiesi

Belongs to the FNDC3 family.Curated
Contains 9 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE8R. Eukaryota.
ENOG410XNUW. LUCA.
GeneTreeiENSGT00860000133770.
HOVERGENiHBG100680.
InParanoidiQ9Y2H6.
OMAiTCLAISW.
OrthoDBiEOG091G047U.
PhylomeDBiQ9Y2H6.
TreeFamiTF316401.

Family and domain databases

CDDicd00063. FN3. 9 hits.
Gene3Di2.60.40.10. 9 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF00041. fn3. 7 hits.
[Graphical view]
SMARTiSM00060. FN3. 9 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 6 hits.
PROSITEiPS50853. FN3. 9 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative promoter usage. AlignAdd to basket

Isoform 1 (identifier: Q9Y2H6-1) [UniParc]FASTAAdd to basket
Also known as: HUGO1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEHPPLLDT TQILSSDISL LSAPIVSADG TQQVILVQVN PGEAFTIRRE
60 70 80 90 100
DGQFQCITGP AQVPMMSPNG SVPPIYVPPG YAPQVIEDNG VRRVVVVPQA
110 120 130 140 150
PEFHPGSHTV LHRSPHPPLP GFIPVPTMMP PPPRHMYSPV TGAGDMTTQY
160 170 180 190 200
MPQYQSSQVY GDVDAHSTHG RSNFRDERSS KTYERLQKKL KDRQGTQKDK
210 220 230 240 250
MSSPPSSPQK CPSPINEHNG LIKGQIAGGI NTGSAKIKSG KGKGGTQVDT
260 270 280 290 300
EIEEKDEETK AFEALLSNIV KPVASDIQAR TVVLTWSPPS SLINGETDES
310 320 330 340 350
SVPELYGYEV LISSTGKDGK YKSVYVGEET NITLNDLKPA MDYHAKVQAE
360 370 380 390 400
YNSIKGTPSE AEIFTTLSCE PDIPNPPRIA NRTKNSLTLQ WKAPSDNGSK
410 420 430 440 450
IQNFVLEWDE GKGNGEFCQC YMGSQKQFKI TKLSPAMGCK FRLSARNDYG
460 470 480 490 500
TSGFSEEVLY YTSGCAPSMP ASPVLTKAGI TWLSLQWSKP SGTPSDEGIS
510 520 530 540 550
YILEMEEETS GYGFKPKYDG EDLAYTVKNL RRSTKYKFKV IAYNSEGKSN
560 570 580 590 600
PSEVVEFTTC PDKPGIPVKP SVKGKIHSHS FKITWDPPKD NGGATINKYV
610 620 630 640 650
VEMAEGSNGN KWEMIYSGAT REHLCDRLNP GCFYRLRVYC ISDGGQSAVS
660 670 680 690 700
ESLLVQTPAV PPGPCLPPRL QGRPKAKEIQ LRWGPPLVDG GSPISCYSVE
710 720 730 740 750
MSPIEKDEPR EVYQGSEVEC TVSSLLPGKT YSFRLRAANK MGFGPFSEKC
760 770 780 790 800
DITTAPGPPD QCKPPQVTCR SATCAQVNWE VPLSNGTDVT EYRLEWGGVE
810 820 830 840 850
GSMQICYCGP GLSYEIKGLS PATTYYCRVQ ALSVVGAGPF SEVVACVTPP
860 870 880 890 900
SVPGIVTCLQ EISDDEIENP HYSPSTCLAI SWEKPCDHGS EILAYSIDFG
910 920 930 940 950
DKQSLTVGKV TSYIINNLQP DTTYRIRIQA LNSLGAGPFS HMIKLKTKPL
960 970 980 990 1000
PPDPPRLECV AFSHQNLKLK WGEGTPKTLS TDSIQYHLQM EDKNGRFVSL
1010 1020 1030 1040 1050
YRGPCHTYKV QRLNESTSYK FCIQACNEAG EGPLSQEYIF TTPKSVPAAL
1060 1070 1080 1090 1100
KAPKIEKVND HICEITWECL QPMKGDPVIY SLQVMLGKDS EFKQIYKGPD
1110 1120 1130 1140 1150
SSFRYSSLQL NCEYRFRVCA IRQCQDSLGH QDLVGPYSTT VLFISQRTEP
1160 1170 1180 1190
PASTNRDTVE STRTRRALSD EQCAAVILVL FAFFSILIAF IIQYFVIK
Length:1,198
Mass (Da):131,852
Last modified:July 28, 2009 - v4
Checksum:i2809E41E89BDD095
GO
Isoform 2 (identifier: Q9Y2H6-2) [UniParc]FASTAAdd to basket
Also known as: HUGO2

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: Missing.
     57-58: IT → MS

Show »
Length:1,142
Mass (Da):125,822
Checksum:i2136F2F51012A73F
GO

Sequence cautioni

The sequence BAA76814 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD18784 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti53Q → R in CAI45989 (PubMed:17974005).Curated1
Sequence conflicti350E → G in CAE45852 (PubMed:17974005).Curated1
Sequence conflicti501Y → H in CAE45852 (PubMed:17974005).Curated1
Sequence conflicti839P → R in AAH60816 (PubMed:15489334).Curated1
Sequence conflicti839P → R in AAH70072 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059655107S → G.Corresponds to variant rs34539036dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0377231 – 56Missing in isoform 2. 4 PublicationsAdd BLAST56
Alternative sequenceiVSP_03772457 – 58IT → MS in isoform 2. 4 Publications2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ749706 mRNA. Translation: CAG44602.1.
AJ749707 mRNA. Translation: CAG44603.1.
AB023187 mRNA. Translation: BAA76814.2. Different initiation.
AK172814 mRNA. Translation: BAD18784.1. Different initiation.
AK302415 mRNA. Translation: BAG63723.1.
BX640739 mRNA. Translation: CAE45852.1.
BX648141 mRNA. Translation: CAI45989.1.
AL161421, AL137000, AL359184 Genomic DNA. Translation: CAH70653.1.
AL359184, AL137000, AL161421 Genomic DNA. Translation: CAH73933.1.
AL137000, AL161421, AL359184 Genomic DNA. Translation: CAI39727.1.
AL137000 Genomic DNA. Translation: CAI39726.2.
CH471075 Genomic DNA. Translation: EAX08804.1.
CH471075 Genomic DNA. Translation: EAX08806.1.
BC060816 mRNA. Translation: AAH60816.1.
BC070072 mRNA. Translation: AAH70072.1.
BC132812 mRNA. Translation: AAI32813.1.
BC136617 mRNA. Translation: AAI36618.1.
BC144301 mRNA. Translation: AAI44302.1.
CCDSiCCDS41886.1. [Q9Y2H6-1]
CCDS9413.2. [Q9Y2H6-2]
RefSeqiNP_001073141.1. NM_001079673.1. [Q9Y2H6-1]
NP_001265367.1. NM_001278438.1. [Q9Y2H6-1]
NP_055738.3. NM_014923.4. [Q9Y2H6-2]
XP_011533299.1. XM_011534997.2.
XP_016875929.1. XM_017020440.1. [Q9Y2H6-1]
XP_016875930.1. XM_017020441.1.
XP_016875931.1. XM_017020442.1.
UniGeneiHs.508010.

Genome annotation databases

EnsembliENST00000398316; ENSP00000381362; ENSG00000102531. [Q9Y2H6-2]
ENST00000492622; ENSP00000417257; ENSG00000102531. [Q9Y2H6-1]
ENST00000541916; ENSP00000441831; ENSG00000102531. [Q9Y2H6-1]
GeneIDi22862.
KEGGihsa:22862.
UCSCiuc001vcm.3. human. [Q9Y2H6-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ749706 mRNA. Translation: CAG44602.1.
AJ749707 mRNA. Translation: CAG44603.1.
AB023187 mRNA. Translation: BAA76814.2. Different initiation.
AK172814 mRNA. Translation: BAD18784.1. Different initiation.
AK302415 mRNA. Translation: BAG63723.1.
BX640739 mRNA. Translation: CAE45852.1.
BX648141 mRNA. Translation: CAI45989.1.
AL161421, AL137000, AL359184 Genomic DNA. Translation: CAH70653.1.
AL359184, AL137000, AL161421 Genomic DNA. Translation: CAH73933.1.
AL137000, AL161421, AL359184 Genomic DNA. Translation: CAI39727.1.
AL137000 Genomic DNA. Translation: CAI39726.2.
CH471075 Genomic DNA. Translation: EAX08804.1.
CH471075 Genomic DNA. Translation: EAX08806.1.
BC060816 mRNA. Translation: AAH60816.1.
BC070072 mRNA. Translation: AAH70072.1.
BC132812 mRNA. Translation: AAI32813.1.
BC136617 mRNA. Translation: AAI36618.1.
BC144301 mRNA. Translation: AAI44302.1.
CCDSiCCDS41886.1. [Q9Y2H6-1]
CCDS9413.2. [Q9Y2H6-2]
RefSeqiNP_001073141.1. NM_001079673.1. [Q9Y2H6-1]
NP_001265367.1. NM_001278438.1. [Q9Y2H6-1]
NP_055738.3. NM_014923.4. [Q9Y2H6-2]
XP_011533299.1. XM_011534997.2.
XP_016875929.1. XM_017020440.1. [Q9Y2H6-1]
XP_016875930.1. XM_017020441.1.
XP_016875931.1. XM_017020442.1.
UniGeneiHs.508010.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WK0NMR-A256-379[»]
1X3DNMR-A361-465[»]
1X4XNMR-A759-851[»]
1X5XNMR-A467-562[»]
2CRMNMR-A554-660[»]
2CRZNMR-A661-757[»]
ProteinModelPortaliQ9Y2H6.
SMRiQ9Y2H6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116530. 39 interactors.
IntActiQ9Y2H6. 25 interactors.
MINTiMINT-3084391.
STRINGi9606.ENSP00000417257.

PTM databases

iPTMnetiQ9Y2H6.
PhosphoSitePlusiQ9Y2H6.
SwissPalmiQ9Y2H6.

Polymorphism and mutation databases

BioMutaiFNDC3A.
DMDMi254763442.

Proteomic databases

EPDiQ9Y2H6.
PaxDbiQ9Y2H6.
PeptideAtlasiQ9Y2H6.
PRIDEiQ9Y2H6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000398316; ENSP00000381362; ENSG00000102531. [Q9Y2H6-2]
ENST00000492622; ENSP00000417257; ENSG00000102531. [Q9Y2H6-1]
ENST00000541916; ENSP00000441831; ENSG00000102531. [Q9Y2H6-1]
GeneIDi22862.
KEGGihsa:22862.
UCSCiuc001vcm.3. human. [Q9Y2H6-1]

Organism-specific databases

CTDi22862.
DisGeNETi22862.
GeneCardsiFNDC3A.
H-InvDBHIX0011312.
HGNCiHGNC:20296. FNDC3A.
HPAiHPA008927.
HPA012825.
MIMi615794. gene.
neXtProtiNX_Q9Y2H6.
OpenTargetsiENSG00000102531.
PharmGKBiPA128394588.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE8R. Eukaryota.
ENOG410XNUW. LUCA.
GeneTreeiENSGT00860000133770.
HOVERGENiHBG100680.
InParanoidiQ9Y2H6.
OMAiTCLAISW.
OrthoDBiEOG091G047U.
PhylomeDBiQ9Y2H6.
TreeFamiTF316401.

Miscellaneous databases

ChiTaRSiFNDC3A. human.
EvolutionaryTraceiQ9Y2H6.
GeneWikiiFNDC3A.
GenomeRNAii22862.
PROiQ9Y2H6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000102531.
CleanExiHS_FNDC3A.
ExpressionAtlasiQ9Y2H6. baseline and differential.
GenevisibleiQ9Y2H6. HS.

Family and domain databases

CDDicd00063. FN3. 9 hits.
Gene3Di2.60.40.10. 9 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF00041. fn3. 7 hits.
[Graphical view]
SMARTiSM00060. FN3. 9 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 6 hits.
PROSITEiPS50853. FN3. 9 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFND3A_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2H6
Secondary accession number(s): B4DYG1
, Q5HYC9, Q5JVF8, Q5JVF9, Q6EVH3, Q6EVH4, Q6N020, Q6P9D5, Q6ZME4, Q9H1W1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 28, 2009
Last modified: November 30, 2016
This is version 146 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.