Q9Y2H6 (FND3A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fibronectin type-III domain-containing protein 3A

Alternative name(s):
Human gene expressed in odontoblasts

Gene names

Name:	FNDC3A
Synonyms:	FNDC3, HUGO, KIAA0970

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1198 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Mediates spermatid-Sertoli adhesion during spermatogenesis By similarity.
Subcellular location	Golgi apparatus membrane; Single-pass membrane protein Potential Ref.1.
Tissue specificity	Expressed in the odontoblast and nerves in the dental pulp. Also expressed in trachea and to a lesser extent in the brain, liver, lung and kidney. Ref.1
Sequence similarities	Belongs to the FNDC3 family. Contains 9 fibronectin type-III domains.
Sequence caution	The sequence BAA76814.2 differs from that shown. Reason: Erroneous initiation. The sequence BAD18784.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Golgi apparatus Membrane
Coding sequence diversity	Alternative promoter usage Polymorphism
Domain	Repeat Transmembrane Transmembrane helix
PTM	Acetylation Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative promoter usage. [Align] [Select]

Isoform 1 (identifier: Q9Y2H6-1)

Also known as: HUGO1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Y2H6-2)

Also known as: HUGO2;

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: Missing.
     57-58: IT → MS

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1198

1198

Fibronectin type-III domain-containing protein 3A

PRO_0000087321

Regions

Transmembrane

1177 – 1197

21

Helical; Potential

Domain

265 – 365

101

Fibronectin type-III 1

Domain

371 – 462

92

Fibronectin type-III 2

Domain

467 – 558

92

Fibronectin type-III 3

Domain

564 – 657

94

Fibronectin type-III 4

Domain

661 – 754

94

Fibronectin type-III 5

Domain

758 – 848

91

Fibronectin type-III 6

Domain

849 – 947

99

Fibronectin type-III 7

Domain

951 – 1042

92

Fibronectin type-III 8

Domain

1047 – 1137

91

Fibronectin type-III 9

Compositional bias

68 – 133

66

Pro-rich

Amino acid modifications

Modified residue

203

1

Phosphoserine Ref.9 Ref.11 Ref.12

Modified residue

206

1

Phosphoserine Ref.12

Modified residue

207

1

Phosphoserine Ref.9 Ref.11 Ref.12

Modified residue

213

1

Phosphoserine Ref.9 Ref.11 Ref.12

Modified residue

259

1

Phosphothreonine Ref.10

Modified residue

384

1

N6-acetyllysine Ref.13

Natural variations

Alternative sequence

1 – 56

56

Missing in isoform 2.

VSP_037723

Alternative sequence

57 – 58

2

IT → MS in isoform 2.

VSP_037724

Natural variant

107

1

S → G.
Corresponds to variant rs34539036 [ dbSNP | Ensembl ].

VAR_059655

Experimental info

Sequence conflict

53

1

Q → R in CAI45989. Ref.5

Sequence conflict

350

1

E → G in CAE45852. Ref.5

Sequence conflict

501

1

Y → H in CAE45852. Ref.5

Sequence conflict

839

1

P → R in AAH60816. Ref.8

Sequence conflict

839

1

P → R in AAH70072. Ref.8

Secondary structure

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1198

Helix Strand Turn

Details...

Helix

256 – 265

10

Beta strand

273 – 276

4

Beta strand

282 – 285

4

Beta strand

307 – 312

6

Beta strand

322 – 328

7

Beta strand

330 – 334

5

Beta strand

345 – 351

7

Beta strand

369 – 371

3

Beta strand

474 – 478

5

Beta strand

480 – 486

7

Beta strand

495 – 498

4

Beta strand

500 – 505

6

Beta strand

508 – 511

4

Beta strand

515 – 521

7

Beta strand

523 – 529

7

Beta strand

535 – 543

9

Beta strand

548 – 551

4

Beta strand

555 – 558

4

Beta strand

571 – 577

7

Beta strand

580 – 584

5

Beta strand

598 – 609

12

Beta strand

613 – 616

4

Beta strand

621 – 625

5

Beta strand

634 – 642

9

Beta strand

676 – 682

7

Beta strand

696 – 702

7

Beta strand

710 – 716

7

Beta strand

718 – 724

7

Beta strand

730 – 733

4

Beta strand

736 – 738

3

Beta strand

750 – 753

4

Beta strand

768 – 771

4

Beta strand

774 – 778

5

Beta strand

785 – 787

3

Beta strand

791 – 799

9

Beta strand

805 – 810

6

Beta strand

812 – 818

7

Beta strand

824 – 832

9

Beta strand

844 – 847

4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (HUGO1) [UniParc]. Last modified July 28, 2009. Version 4. Checksum: 2809E41E89BDD095	FASTA	1,198	131,852
	10 20 30 40 50 60 MAEHPPLLDT TQILSSDISL LSAPIVSADG TQQVILVQVN PGEAFTIRRE DGQFQCITGP 70 80 90 100 110 120 AQVPMMSPNG SVPPIYVPPG YAPQVIEDNG VRRVVVVPQA PEFHPGSHTV LHRSPHPPLP 130 140 150 160 170 180 GFIPVPTMMP PPPRHMYSPV TGAGDMTTQY MPQYQSSQVY GDVDAHSTHG RSNFRDERSS 190 200 210 220 230 240 KTYERLQKKL KDRQGTQKDK MSSPPSSPQK CPSPINEHNG LIKGQIAGGI NTGSAKIKSG 250 260 270 280 290 300 KGKGGTQVDT EIEEKDEETK AFEALLSNIV KPVASDIQAR TVVLTWSPPS SLINGETDES 310 320 330 340 350 360 SVPELYGYEV LISSTGKDGK YKSVYVGEET NITLNDLKPA MDYHAKVQAE YNSIKGTPSE 370 380 390 400 410 420 AEIFTTLSCE PDIPNPPRIA NRTKNSLTLQ WKAPSDNGSK IQNFVLEWDE GKGNGEFCQC 430 440 450 460 470 480 YMGSQKQFKI TKLSPAMGCK FRLSARNDYG TSGFSEEVLY YTSGCAPSMP ASPVLTKAGI 490 500 510 520 530 540 TWLSLQWSKP SGTPSDEGIS YILEMEEETS GYGFKPKYDG EDLAYTVKNL RRSTKYKFKV 550 560 570 580 590 600 IAYNSEGKSN PSEVVEFTTC PDKPGIPVKP SVKGKIHSHS FKITWDPPKD NGGATINKYV 610 620 630 640 650 660 VEMAEGSNGN KWEMIYSGAT REHLCDRLNP GCFYRLRVYC ISDGGQSAVS ESLLVQTPAV 670 680 690 700 710 720 PPGPCLPPRL QGRPKAKEIQ LRWGPPLVDG GSPISCYSVE MSPIEKDEPR EVYQGSEVEC 730 740 750 760 770 780 TVSSLLPGKT YSFRLRAANK MGFGPFSEKC DITTAPGPPD QCKPPQVTCR SATCAQVNWE 790 800 810 820 830 840 VPLSNGTDVT EYRLEWGGVE GSMQICYCGP GLSYEIKGLS PATTYYCRVQ ALSVVGAGPF 850 860 870 880 890 900 SEVVACVTPP SVPGIVTCLQ EISDDEIENP HYSPSTCLAI SWEKPCDHGS EILAYSIDFG 910 920 930 940 950 960 DKQSLTVGKV TSYIINNLQP DTTYRIRIQA LNSLGAGPFS HMIKLKTKPL PPDPPRLECV 970 980 990 1000 1010 1020 AFSHQNLKLK WGEGTPKTLS TDSIQYHLQM EDKNGRFVSL YRGPCHTYKV QRLNESTSYK 1030 1040 1050 1060 1070 1080 FCIQACNEAG EGPLSQEYIF TTPKSVPAAL KAPKIEKVND HICEITWECL QPMKGDPVIY 1090 1100 1110 1120 1130 1140 SLQVMLGKDS EFKQIYKGPD SSFRYSSLQL NCEYRFRVCA IRQCQDSLGH QDLVGPYSTT 1150 1160 1170 1180 1190 VLFISQRTEP PASTNRDTVE STRTRRALSD EQCAAVILVL FAFFSILIAF IIQYFVIK
	Isoform 2 (HUGO2) [UniParc]. Checksum: 2136F2F51012A73F	FASTA	1,142	125,822
	10 20 30 40 50 60 MSGPAQVPMM SPNGSVPPIY VPPGYAPQVI EDNGVRRVVV VPQAPEFHPG SHTVLHRSPH 70 80 90 100 110 120 PPLPGFIPVP TMMPPPPRHM YSPVTGAGDM TTQYMPQYQS SQVYGDVDAH STHGRSNFRD 130 140 150 160 170 180 ERSSKTYERL QKKLKDRQGT QKDKMSSPPS SPQKCPSPIN EHNGLIKGQI AGGINTGSAK 190 200 210 220 230 240 IKSGKGKGGT QVDTEIEEKD EETKAFEALL SNIVKPVASD IQARTVVLTW SPPSSLINGE 250 260 270 280 290 300 TDESSVPELY GYEVLISSTG KDGKYKSVYV GEETNITLND LKPAMDYHAK VQAEYNSIKG 310 320 330 340 350 360 TPSEAEIFTT LSCEPDIPNP PRIANRTKNS LTLQWKAPSD NGSKIQNFVL EWDEGKGNGE 370 380 390 400 410 420 FCQCYMGSQK QFKITKLSPA MGCKFRLSAR NDYGTSGFSE EVLYYTSGCA PSMPASPVLT 430 440 450 460 470 480 KAGITWLSLQ WSKPSGTPSD EGISYILEME EETSGYGFKP KYDGEDLAYT VKNLRRSTKY 490 500 510 520 530 540 KFKVIAYNSE GKSNPSEVVE FTTCPDKPGI PVKPSVKGKI HSHSFKITWD PPKDNGGATI 550 560 570 580 590 600 NKYVVEMAEG SNGNKWEMIY SGATREHLCD RLNPGCFYRL RVYCISDGGQ SAVSESLLVQ 610 620 630 640 650 660 TPAVPPGPCL PPRLQGRPKA KEIQLRWGPP LVDGGSPISC YSVEMSPIEK DEPREVYQGS 670 680 690 700 710 720 EVECTVSSLL PGKTYSFRLR AANKMGFGPF SEKCDITTAP GPPDQCKPPQ VTCRSATCAQ 730 740 750 760 770 780 VNWEVPLSNG TDVTEYRLEW GGVEGSMQIC YCGPGLSYEI KGLSPATTYY CRVQALSVVG 790 800 810 820 830 840 AGPFSEVVAC VTPPSVPGIV TCLQEISDDE IENPHYSPST CLAISWEKPC DHGSEILAYS 850 860 870 880 890 900 IDFGDKQSLT VGKVTSYIIN NLQPDTTYRI RIQALNSLGA GPFSHMIKLK TKPLPPDPPR 910 920 930 940 950 960 LECVAFSHQN LKLKWGEGTP KTLSTDSIQY HLQMEDKNGR FVSLYRGPCH TYKVQRLNES 970 980 990 1000 1010 1020 TSYKFCIQAC NEAGEGPLSQ EYIFTTPKSV PAALKAPKIE KVNDHICEIT WECLQPMKGD 1030 1040 1050 1060 1070 1080 PVIYSLQVML GKDSEFKQIY KGPDSSFRYS SLQLNCEYRF RVCAIRQCQD SLGHQDLVGP 1090 1100 1110 1120 1130 1140 YSTTVLFISQ RTEPPASTNR DTVESTRTRR ALSDEQCAAV ILVLFAFFSI LIAFIIQYFV IK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"HUGO (FNDC3A): a new gene overexpressed in human odontoblasts." Carrouel F., Couble M.-L., Vanbelle C., Staquet M.-J., Magloire H., Bleicher F. J. Dent. Res. 87:131-136(2008) [PubMed: 18218838] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), ALTERNATIVE PROMOTER USAGE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Dental pulp and Odontoblast.
[2]	"Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 6:63-70(1999) [PubMed: 10231032] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[3]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed: 12168954] [Abstract] Cited for: SEQUENCE REVISION.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Testis.
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Cervix and Fetal kidney.
[6]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed: 15057823] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain, Placenta and Testis.
[9]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-203; SER-207 AND SER-213, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry." Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A. Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007) [PubMed: 17287340] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-259, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[11]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-203; SER-207 AND SER-213, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-203; SER-206; SER-207 AND SER-213, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[13]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-384, MASS SPECTROMETRY.
[14]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[15]	"Solution structure of fibronectin type III domains derived from human KIAA0970 protein." RIKEN structural genomics initiative (RSGI) Submitted (JAN-2006) to the PDB data bank Cited for: STRUCTURE BY NMR OF 256-851.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AJ749706 mRNA. Translation: CAG44602.1.
AJ749707 mRNA. Translation: CAG44603.1.
AB023187 mRNA. Translation: BAA76814.2. Different initiation.
AK172814 mRNA. Translation: BAD18784.1. Different initiation.
AK302415 mRNA. Translation: BAG63723.1.
BX640739 mRNA. Translation: CAE45852.1.
BX648141 mRNA. Translation: CAI45989.1.
AL161421, AL137000, AL359184 Genomic DNA. Translation: CAH70653.1.
AL359184, AL137000, AL161421 Genomic DNA. Translation: CAH73933.1.
AL137000, AL161421, AL359184 Genomic DNA. Translation: CAI39727.1.
AL137000 Genomic DNA. Translation: CAI39726.2.
CH471075 Genomic DNA. Translation: EAX08804.1.
CH471075 Genomic DNA. Translation: EAX08806.1.
BC060816 mRNA. Translation: AAH60816.1.
BC070072 mRNA. Translation: AAH70072.1.
BC132812 mRNA. Translation: AAI32813.1.
BC136617 mRNA. Translation: AAI36618.1.
BC144301 mRNA. Translation: AAI44302.1.

IPI

IPI00456630.
IPI00549232.

RefSeq

NP_001073141.1. NM_001079673.1.
NP_055738.3. NM_014923.3.

UniGene

Hs.508010.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1WK0	NMR	-	A	256-379	[»]
1X3D	NMR	-	A	361-465	[»]
1X4X	NMR	-	A	759-851	[»]
1X5X	NMR	-	A	467-562	[»]
2CRM	NMR	-	A	554-660	[»]
2CRZ	NMR	-	A	661-757	[»]

ProteinModelPortal

Q9Y2H6.

SMR

Q9Y2H6. Positions 256-1152.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9Y2H6. 5 interactions.

STRING

Q9Y2H6.

PTM databases

PhosphoSite

Q9Y2H6.

Polymorphism databases

DMDM

254763442.

Proteomic databases

PRIDE

Q9Y2H6.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000492622; ENSP00000417257; ENSG00000102531.

GeneID

22862.

KEGG

hsa:22862.

UCSC

uc001vcm.1. human.

Organism-specific databases

CTD

22862.

GeneCards

GC13P049550.

H-InvDB

HIX0011312.

HGNC

HGNC:20296. FNDC3A.

HPA

HPA008927.
HPA012825.

neXtProt

NX_Q9Y2H6.

PharmGKB

PA128394588.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

GeneTree

ENSGT00530000063598.

HOVERGEN

HBG100680.

InParanoid

Q9Y2H6.

OMA

CDHGSEI.

OrthoDB

EOG4K3KVG.

PhylomeDB

Q9Y2H6.

Gene expression databases

ArrayExpress

Q9Y2H6.

Bgee

Q9Y2H6.

CleanEx

HS_FNDC3A.

Genevestigator

Q9Y2H6.

GermOnline

ENSG00000102531. Homo sapiens.

Family and domain databases

InterPro

IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
[Graphical view]

Gene3D

G3DSA:2.60.40.10. Ig-like_fold. 9 hits.

Pfam

PF00041. fn3. 8 hits.
[Graphical view]

SMART

SM00060. FN3. 9 hits.
[Graphical view]

SUPFAM

SSF49265. FN_III-like. 9 hits.

PROSITE

PS50853. FN3. 9 hits.
[Graphical view]

ProtoNet

Search...

Other

NextBio

43369.

Entry information

Entry name

FND3A_HUMAN

Accession

Primary (citable) accession number: Q9Y2H6
Secondary accession number(s): B4DYG1 , Q5HYC9, Q5JVF8, Q5JVF9, Q6EVH3, Q6EVH4, Q6N020, Q6P9D5, Q6ZME4, Q9H1W1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	July 28, 2009
Last modified:	January 25, 2012
This is version 97 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.