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Protein

Pleckstrin homology domain-containing family A member 6

Gene

PLEKHA6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Pleckstrin homology domain-containing family A member 6
Short name:
PH domain-containing family A member 6
Alternative name(s):
Phosphoinositol 3-phosphate-binding protein 3
Short name:
PEPP-3
Gene namesi
Name:PLEKHA6
Synonyms:KIAA0969, PEPP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:17053. PLEKHA6.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134955964.

Polymorphism and mutation databases

BioMutaiPLEKHA6.
DMDMi160334379.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10481048Pleckstrin homology domain-containing family A member 6PRO_0000053884Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei247 – 2471PhosphoserineBy similarity
Modified residuei251 – 2511PhosphoserineBy similarity
Modified residuei314 – 3141PhosphoserineBy similarity
Modified residuei459 – 4591PhosphoserineCombined sources
Modified residuei461 – 4611PhosphoserineCombined sources
Modified residuei472 – 4721PhosphoserineCombined sources
Modified residuei492 – 4921PhosphotyrosineBy similarity
Modified residuei591 – 5911PhosphoserineCombined sources
Modified residuei744 – 7441PhosphothreonineBy similarity
Modified residuei777 – 7771PhosphoserineCombined sources
Modified residuei784 – 7841PhosphothreonineBy similarity
Modified residuei801 – 8011PhosphoserineBy similarity
Modified residuei848 – 8481PhosphoserineCombined sources
Modified residuei854 – 8541PhosphoserineCombined sources
Modified residuei867 – 8671PhosphoserineCombined sources
Modified residuei1015 – 10151PhosphothreonineBy similarity
Modified residuei1017 – 10171PhosphoserineCombined sources
Modified residuei1020 – 10201PhosphothreonineBy similarity
Modified residuei1021 – 10211PhosphoserineBy similarity
Modified residuei1024 – 10241PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y2H5.
MaxQBiQ9Y2H5.
PaxDbiQ9Y2H5.
PRIDEiQ9Y2H5.

PTM databases

iPTMnetiQ9Y2H5.
PhosphoSiteiQ9Y2H5.

Expressioni

Tissue specificityi

Highly expressed in heart, kidney and throughout the brain.

Gene expression databases

BgeeiQ9Y2H5.
CleanExiHS_PLEKHA6.
ExpressionAtlasiQ9Y2H5. baseline and differential.
GenevisibleiQ9Y2H5. HS.

Organism-specific databases

HPAiHPA028152.
HPA054311.

Interactioni

Protein-protein interaction databases

BioGridi116541. 6 interactions.
IntActiQ9Y2H5. 3 interactions.
STRINGi9606.ENSP00000272203.

Structurei

Secondary structure

1
1048
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi62 – 698Combined sources
Beta strandi73 – 753Combined sources
Beta strandi77 – 859Combined sources
Beta strandi88 – 947Combined sources
Beta strandi102 – 1054Combined sources
Beta strandi110 – 1134Combined sources
Turni116 – 1194Combined sources
Beta strandi123 – 1297Combined sources
Beta strandi131 – 1333Combined sources
Beta strandi135 – 1395Combined sources
Helixi143 – 15513Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2D9YNMR-A57-160[»]
2YRYNMR-A46-160[»]
ProteinModelPortaliQ9Y2H5.
SMRiQ9Y2H5. Positions 47-160.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y2H5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini59 – 158100PHPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi162 – 386225Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 PH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IKMF. Eukaryota.
ENOG410ZX2B. LUCA.
GeneTreeiENSGT00530000063012.
HOGENOMiHOG000115554.
HOVERGENiHBG099912.
InParanoidiQ9Y2H5.
OrthoDBiEOG7VDXNZ.
PhylomeDBiQ9Y2H5.
TreeFamiTF329090.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y2H5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNKTGGKRP ATTNSDIPNH NMVSEVPPER PSVRATRTAR KAVAFGKRSH
60 70 80 90 100
SMKRNPNAPV TKAGWLFKQA SSGVKQWNKR WFVLVDRCLF YYKDEKEESI
110 120 130 140 150
LGSIPLLSFR VAAVQPSDNI SRKHTFKAEH AGVRTYFFSA ESPEEQEAWI
160 170 180 190 200
QAMGEAARVQ IPPAQKSVPQ AVRHSHEKPD SENVPPSKHH QQPPHNSLPK
210 220 230 240 250
PEPEAKTRGE GDGRGCEKAE RRPERPEVKK EPPVKANGLP AGPEPASEPG
260 270 280 290 300
SPYPEGPRVP GGGEQPAQPN GWQYHSPSRP GSTAFPSQDG ETGGHRRSFP
310 320 330 340 350
PRTNPDKIAQ RKSSMNQLQQ WVNLRRGVPP PEDLRSPSRF YPVSRRVPEY
360 370 380 390 400
YGPYSSQYPD DYQYYPPGVR PESICSMPAY DRISPPWALE DKRHAFRNGG
410 420 430 440 450
GPAYQLREWK EPASYGRQDA TVWIPSPSRQ PVYYDELDAA SSSLRRLSLQ
460 470 480 490 500
PRSHSVPRSP SQGSYSRARI YSPVRSPSAR FERLPPRSED IYADPAAYVM
510 520 530 540 550
RRSISSPKVP PYPEVFRDSL HTYKLNEQDT DKLLGKLCEQ NKVVREQDRL
560 570 580 590 600
VQQLRAEKES LESALMGTHQ ELEMFGSQPA YPEKLRHKKD SLQNQLINIR
610 620 630 640 650
VELSQATTAL TNSTIEYEHL ESEVSALHDD LWEQLNLDTQ NEVLNRQIQK
660 670 680 690 700
EIWRIQDVME GLRKNNPSRG TDTAKHRGGL GPSATYSSNS PASPLSSASL
710 720 730 740 750
TSPLSPFSLV SGSQGSPTKP GSNEPKANYE QSKKDPHQTL PLDTPRDISL
760 770 780 790 800
VPTRQEVEAE KQAALNKVGV VPPRTKSPTD DEVTPSAVVR RNASGLTNGL
810 820 830 840 850
SSQERPKSAV FPGEGKVKMS VEEQIDRMRR HQSGSMREKR RSLQLPASPA
860 870 880 890 900
PDPSPRPAYK VVRRHRSIHE VDISNLEAAL RAEEPGGHAY ETPREEIARL
910 920 930 940 950
RKMELEPQHY DVDINKELST PDKVLIPERY IDLEPDTPLS PEELKEKQKK
960 970 980 990 1000
VERIKTLIAK SSMQNVVPIG EGDSVDVPQD SESQLQEQEK RIEISCALAT
1010 1020 1030 1040
EASRRGRMLS VQCATPSPPT SPASPAPPAN PLSSESPRGA DSSYTMRV
Length:1,048
Mass (Da):117,128
Last modified:November 13, 2007 - v4
Checksum:i230F7CB49C9DDF32
GO

Sequence cautioni

The sequence BAA76813.2 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti43 – 431V → I.2 Publications
Corresponds to variant rs10900571 [ dbSNP | Ensembl ].
VAR_037145
Natural varianti837 – 8371R → K.2 Publications
Corresponds to variant rs10900562 [ dbSNP | Ensembl ].
VAR_037146

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023186 mRNA. Translation: BAA76813.2. Different initiation.
AL592114 Genomic DNA. Translation: CAH71228.1.
BC152475 mRNA. Translation: AAI52476.1.
CCDSiCCDS1444.1.
RefSeqiNP_055750.2. NM_014935.4.
XP_005245025.2. XM_005244968.3.
UniGeneiHs.253146.

Genome annotation databases

EnsembliENST00000272203; ENSP00000272203; ENSG00000143850.
GeneIDi22874.
KEGGihsa:22874.
UCSCiuc001hau.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023186 mRNA. Translation: BAA76813.2. Different initiation.
AL592114 Genomic DNA. Translation: CAH71228.1.
BC152475 mRNA. Translation: AAI52476.1.
CCDSiCCDS1444.1.
RefSeqiNP_055750.2. NM_014935.4.
XP_005245025.2. XM_005244968.3.
UniGeneiHs.253146.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2D9YNMR-A57-160[»]
2YRYNMR-A46-160[»]
ProteinModelPortaliQ9Y2H5.
SMRiQ9Y2H5. Positions 47-160.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116541. 6 interactions.
IntActiQ9Y2H5. 3 interactions.
STRINGi9606.ENSP00000272203.

PTM databases

iPTMnetiQ9Y2H5.
PhosphoSiteiQ9Y2H5.

Polymorphism and mutation databases

BioMutaiPLEKHA6.
DMDMi160334379.

Proteomic databases

EPDiQ9Y2H5.
MaxQBiQ9Y2H5.
PaxDbiQ9Y2H5.
PRIDEiQ9Y2H5.

Protocols and materials databases

DNASUi22874.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000272203; ENSP00000272203; ENSG00000143850.
GeneIDi22874.
KEGGihsa:22874.
UCSCiuc001hau.5. human.

Organism-specific databases

CTDi22874.
GeneCardsiPLEKHA6.
H-InvDBHIX0001495.
HGNCiHGNC:17053. PLEKHA6.
HPAiHPA028152.
HPA054311.
MIMi607771. gene.
neXtProtiNX_Q9Y2H5.
PharmGKBiPA134955964.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKMF. Eukaryota.
ENOG410ZX2B. LUCA.
GeneTreeiENSGT00530000063012.
HOGENOMiHOG000115554.
HOVERGENiHBG099912.
InParanoidiQ9Y2H5.
OrthoDBiEOG7VDXNZ.
PhylomeDBiQ9Y2H5.
TreeFamiTF329090.

Miscellaneous databases

ChiTaRSiPLEKHA6. human.
EvolutionaryTraceiQ9Y2H5.
GeneWikiiPLEKHA6.
GenomeRNAii22874.
NextBioi43425.
PROiQ9Y2H5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y2H5.
CleanExiHS_PLEKHA6.
ExpressionAtlasiQ9Y2H5. baseline and differential.
GenevisibleiQ9Y2H5. HS.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ILE-43 AND LYS-837.
    Tissue: Brain.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ILE-43 AND LYS-837.
  4. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-848 AND SER-854, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-472 AND SER-867, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-459; SER-461; SER-591; SER-777 AND SER-1017, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  7. "Solution structure of the PH domain of PEPP-3 from human."
    RIKEN structural genomics initiative (RSGI)
    Submitted (OCT-2007) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 57-160.

Entry informationi

Entry nameiPKHA6_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2H5
Secondary accession number(s): A7MD51, Q5VTI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: November 13, 2007
Last modified: May 11, 2016
This is version 122 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.