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Q9Y2H2

- SAC2_HUMAN

UniProt

Q9Y2H2 - SAC2_HUMAN

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Protein
Phosphatidylinositide phosphatase SAC2
Gene
INPP5F, KIAA0966, SAC2, MSTP007, MSTP047
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Inositol 5-phosphatase which acts on phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Hydrolyzes phosphatidylinositol 4,5-bisphosphate most effectively. Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation.2 Publications

Kineticsi

  1. KM=14.3 µM for PtdIns(4,5)P2 (at pH 6.0)1 Publication

GO - Molecular functioni

  1. phosphoric ester hydrolase activity Source: InterPro

GO - Biological processi

  1. cardiac muscle hypertrophy in response to stress Source: Ensembl
  2. phosphatidylinositol catabolic process Source: Ensembl
  3. phosphatidylinositol-mediated signaling Source: Ensembl
  4. regulation of protein kinase B signaling Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciMetaCyc:HS12255-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositide phosphatase SAC2 (EC:3.1.3.-)
Alternative name(s):
Inositol polyphosphate 5-phosphatase F
Sac domain-containing inositol phosphatase 2
Sac domain-containing phosphoinositide 5-phosphatase 2
Short name:
hSAC2
Gene namesi
Name:INPP5F
Synonyms:KIAA0966, SAC2
ORF Names:MSTP007, MSTP047
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:17054. INPP5F.

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi460 – 4601D → A: Loss of phosphatase activity. 1 Publication

Organism-specific databases

PharmGKBiPA134927878.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11321132Phosphatidylinositide phosphatase SAC2
PRO_0000331621Add
BLAST

Proteomic databases

MaxQBiQ9Y2H2.
PaxDbiQ9Y2H2.
PRIDEiQ9Y2H2.

PTM databases

PhosphoSiteiQ9Y2H2.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

ArrayExpressiQ9Y2H2.
BgeeiQ9Y2H2.
CleanExiHS_INPP5F.
GenevestigatoriQ9Y2H2.

Organism-specific databases

HPAiHPA042605.

Interactioni

Protein-protein interaction databases

BioGridi116543. 1 interaction.
IntActiQ9Y2H2. 1 interaction.
STRINGi9606.ENSP00000354519.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2H2.
SMRiQ9Y2H2. Positions 5-520.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini167 – 518352SAC
Add
BLAST

Sequence similaritiesi

Contains 1 SAC domain.

Phylogenomic databases

eggNOGiCOG5329.
HOVERGENiHBG095361.
InParanoidiQ9Y2H2.
OMAiENTGVMD.
OrthoDBiEOG73803W.
PhylomeDBiQ9Y2H2.
TreeFamiTF313543.

Family and domain databases

InterProiIPR022158. Inositol_phosphatase.
IPR002013. Syja_N.
[Graphical view]
PfamiPF12456. hSac2. 1 hit.
PF02383. Syja_N. 1 hit.
[Graphical view]
PROSITEiPS50275. SAC. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9Y2H2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MELFQAKDHY ILQQGERALW CSRRDGGLQL RPATDLLLAW NPICLGLVEG     50
VIGKIQLHSD LPWWLILIRQ KALVGKLPGD HEVCKVTKIA VLSLSEMEPQ 100
DLELELCKKH HFGINKPEKI IPSPDDSKFL LKTFTHIKSN VSAPNKKKVK 150
ESKEKEKLER RLLEELLKMF MDSESFYYSL TYDLTNSVQR QSTGERDGRP 200
LWQKVDDRFF WNKYMIQDLT EIGTPDVDFW IIPMIQGFVQ IEELVVNYTE 250
SSDDEKSSPE TPPQESTCVD DIHPRFLVAL ISRRSRHRAG MRYKRRGVDK 300
NGNVANYVET EQLIHVHNHT LSFVQTRGSV PVFWSQVGYR YNPRPRLDRS 350
EKETVAYFCA HFEEQLNIYK KQVIINLVDQ AGREKIIGDA YLKQVLLFNN 400
SHLTYVSFDF HEHCRGMKFE NVQTLTDAIY DIILDMKWCW VDEAGVICKQ 450
EGIFRVNCMD CLDRTNVVQA AIARVVMEQQ LKKLGVMPPE QPLPVKCNRI 500
YQIMWANNGD SISRQYAGTA ALKGDFTRTG ERKLAGVMKD GVNSANRYYL 550
NRFKDAYRQA VIDLMQGIPV TEDLYSIFTK EKEHEALHKE NQRSHQELIS 600
QLLQSYMKLL LPDDEKFHGG WALIDCDPSL IDATHRDVDV LLLLSNSAYY 650
VAYYDDEVDK VNQYQRLSLE NLEKIEIGPE PTLFGKPKFS CMRLHYRYKE 700
ASGYFHTLRA VMRNPEEDGK DTLQCIAEML QITKQAMGSD LPIIEKKLER 750
KSSKPHEDII GIRSQNQGSL AQGKNFLMSK FSSLNQKVKQ TKSNVNIGNL 800
RKLGNFTKPE MKVNFLKPNL KVNLWKSDSS LETMENTGVM DKVQAESDGD 850
MSSDNDSYHS DEFLTNSKSD EDRQLANSLE SVGPIDYVLP SCGIIASAPR 900
LGSRSQSLSS TDSSVHAPSE ITVAHGSGLG KGQESPLKKS PSAGDVHILT 950
GFAKPMDIYC HRFVQDAQNK VTHLSETRSV SQQASQERNQ MTNQVSNETQ 1000
SESTEQTPSR PSQLDVSLSA TGPQFLSVEP AHSVASQKTP TSASSMLELE 1050
TGLHVTPSPS ESSSSRAVSP FAKIRSSMVQ VASITQAGLT HGINFAVSKV 1100
QKSPPEPEII NQVQQNELKK MFIQCQTRII QI 1132
Length:1,132
Mass (Da):128,407
Last modified:April 29, 2008 - v3
Checksum:i853719FC0AD455CD
GO
Isoform 2 (identifier: Q9Y2H2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     373-375: VII → QQK
     376-1132: Missing.

Show »
Length:375
Mass (Da):43,817
Checksum:iE9A76393F10C6CC3
GO
Isoform 3 (identifier: Q9Y2H2-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     206-219: DDRFFWNKYMIQDL → PLTARRAGFALGKK
     220-1132: Missing.

Show »
Length:219
Mass (Da):25,174
Checksum:i8AAA498682414245
GO
Isoform 4 (identifier: Q9Y2H2-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: MELFQAKDHYILQQGERAL → MCHDVIFMAWLKQQFSECT
     20-629: Missing.

Note: No experimental confirmation available.

Show »
Length:522
Mass (Da):57,800
Checksum:i8A15030B00C8E9A1
GO

Sequence cautioni

The sequence BAA76810.2 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti453 – 4531I → V.
Corresponds to variant rs3736822 [ dbSNP | Ensembl ].
VAR_042907
Natural varianti997 – 9971N → D.2 Publications
Corresponds to variant rs3188055 [ dbSNP | Ensembl ].
VAR_042908

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1919MELFQ…GERAL → MCHDVIFMAWLKQQFSECT in isoform 4.
VSP_046366Add
BLAST
Alternative sequencei20 – 629610Missing in isoform 4.
VSP_046367Add
BLAST
Alternative sequencei206 – 21914DDRFF…MIQDL → PLTARRAGFALGKK in isoform 3.
VSP_033266Add
BLAST
Alternative sequencei220 – 1132913Missing in isoform 3.
VSP_033267Add
BLAST
Alternative sequencei373 – 3753VII → QQK in isoform 2.
VSP_033268
Alternative sequencei376 – 1132757Missing in isoform 2.
VSP_033269Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti386 – 3861I → V in AAI11494. 1 Publication
Sequence conflicti654 – 6541Y → N in BAG52363. 1 Publication
Sequence conflicti1008 – 10081P → L in BAG52363. 1 Publication
Sequence conflicti1019 – 10191S → P in BAG52363. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB023183 mRNA. Translation: BAA76810.2. Different initiation.
AK091448 mRNA. Translation: BAG52363.1.
AC027672 Genomic DNA. No translation available.
AL133461, AL158014 Genomic DNA. Translation: CAH72974.1.
AL158014, AL133461 Genomic DNA. Translation: CAI16957.1.
CH471066 Genomic DNA. Translation: EAW49379.1.
CH471066 Genomic DNA. Translation: EAW49380.1.
CH471066 Genomic DNA. Translation: EAW49381.1.
BC052367 mRNA. Translation: AAH52367.1.
BC067820 mRNA. Translation: AAH67820.1.
BC082755 mRNA. Translation: AAH82755.1.
BC111493 mRNA. Translation: AAI11494.1.
AL137528 mRNA. Translation: CAB70792.1.
AF113227 mRNA. Translation: AAG39298.1.
AF109361 mRNA. Translation: AAQ13509.1.
CCDSiCCDS58098.1. [Q9Y2H2-4]
CCDS7616.1. [Q9Y2H2-1]
PIRiT46372.
RefSeqiNP_001230123.1. NM_001243194.1. [Q9Y2H2-4]
NP_001230124.1. NM_001243195.1. [Q9Y2H2-3]
NP_055752.1. NM_014937.3. [Q9Y2H2-1]
UniGeneiHs.369755.

Genome annotation databases

EnsembliENST00000361976; ENSP00000354519; ENSG00000198825. [Q9Y2H2-1]
ENST00000369080; ENSP00000358076; ENSG00000198825. [Q9Y2H2-4]
ENST00000369083; ENSP00000358079; ENSG00000198825. [Q9Y2H2-2]
GeneIDi22876.
KEGGihsa:22876.
UCSCiuc001len.4. human. [Q9Y2H2-3]
uc001leo.3. human. [Q9Y2H2-1]

Polymorphism databases

DMDMi187611527.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB023183 mRNA. Translation: BAA76810.2 . Different initiation.
AK091448 mRNA. Translation: BAG52363.1 .
AC027672 Genomic DNA. No translation available.
AL133461 , AL158014 Genomic DNA. Translation: CAH72974.1 .
AL158014 , AL133461 Genomic DNA. Translation: CAI16957.1 .
CH471066 Genomic DNA. Translation: EAW49379.1 .
CH471066 Genomic DNA. Translation: EAW49380.1 .
CH471066 Genomic DNA. Translation: EAW49381.1 .
BC052367 mRNA. Translation: AAH52367.1 .
BC067820 mRNA. Translation: AAH67820.1 .
BC082755 mRNA. Translation: AAH82755.1 .
BC111493 mRNA. Translation: AAI11494.1 .
AL137528 mRNA. Translation: CAB70792.1 .
AF113227 mRNA. Translation: AAG39298.1 .
AF109361 mRNA. Translation: AAQ13509.1 .
CCDSi CCDS58098.1. [Q9Y2H2-4 ]
CCDS7616.1. [Q9Y2H2-1 ]
PIRi T46372.
RefSeqi NP_001230123.1. NM_001243194.1. [Q9Y2H2-4 ]
NP_001230124.1. NM_001243195.1. [Q9Y2H2-3 ]
NP_055752.1. NM_014937.3. [Q9Y2H2-1 ]
UniGenei Hs.369755.

3D structure databases

ProteinModelPortali Q9Y2H2.
SMRi Q9Y2H2. Positions 5-520.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116543. 1 interaction.
IntActi Q9Y2H2. 1 interaction.
STRINGi 9606.ENSP00000354519.

PTM databases

PhosphoSitei Q9Y2H2.

Polymorphism databases

DMDMi 187611527.

Proteomic databases

MaxQBi Q9Y2H2.
PaxDbi Q9Y2H2.
PRIDEi Q9Y2H2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000361976 ; ENSP00000354519 ; ENSG00000198825 . [Q9Y2H2-1 ]
ENST00000369080 ; ENSP00000358076 ; ENSG00000198825 . [Q9Y2H2-4 ]
ENST00000369083 ; ENSP00000358079 ; ENSG00000198825 . [Q9Y2H2-2 ]
GeneIDi 22876.
KEGGi hsa:22876.
UCSCi uc001len.4. human. [Q9Y2H2-3 ]
uc001leo.3. human. [Q9Y2H2-1 ]

Organism-specific databases

CTDi 22876.
GeneCardsi GC10P121475.
HGNCi HGNC:17054. INPP5F.
HPAi HPA042605.
MIMi 609389. gene.
neXtProti NX_Q9Y2H2.
PharmGKBi PA134927878.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5329.
HOVERGENi HBG095361.
InParanoidi Q9Y2H2.
OMAi ENTGVMD.
OrthoDBi EOG73803W.
PhylomeDBi Q9Y2H2.
TreeFami TF313543.

Enzyme and pathway databases

BioCyci MetaCyc:HS12255-MONOMER.

Miscellaneous databases

GenomeRNAii 22876.
NextBioi 35469521.
PROi Q9Y2H2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9Y2H2.
Bgeei Q9Y2H2.
CleanExi HS_INPP5F.
Genevestigatori Q9Y2H2.

Family and domain databases

InterProi IPR022158. Inositol_phosphatase.
IPR002013. Syja_N.
[Graphical view ]
Pfami PF12456. hSac2. 1 hit.
PF02383. Syja_N. 1 hit.
[Graphical view ]
PROSITEi PS50275. SAC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of a sac domain-containing phosphoinositide 5-phosphatase."
    Minagawa T., Ijuin T., Mochizuki Y., Takenawa T.
    J. Biol. Chem. 276:22011-22015(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, ENZYME ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, MUTAGENESIS OF ASP-460, TISSUE SPECIFICITY.
  2. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASP-997.
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Brain.
  4. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), VARIANT ASP-997.
    Tissue: Placenta and Skin.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 274-1132 (ISOFORM 1).
    Tissue: Testis.
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 956-1132 (ISOFORM 1).
    Tissue: Aorta.
  9. Cited for: FUNCTION.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSAC2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2H2
Secondary accession number(s): B3KRF1
, D3DRD1, Q2T9J4, Q5W135, Q5W136, Q6NVY2, Q86U97, Q9H3D9, Q9NT51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: July 9, 2014
This is version 94 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Inositol polyphosphate 5-phosphatases usually have 2 conserved motifs that are essential for 5-phosphatase activity. However, INPP5F does not contain such motifs, and phosphatase activity seems to exist in the SAC domain, suggesting a new type of phosphoinositide 5-phosphatase.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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