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Q9Y2H2

- SAC2_HUMAN

UniProt

Q9Y2H2 - SAC2_HUMAN

Protein

Phosphatidylinositide phosphatase SAC2

Gene

INPP5F

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 3 (29 Apr 2008)
      Previous versions | rss
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    Functioni

    Inositol 5-phosphatase which acts on phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Hydrolyzes phosphatidylinositol 4,5-bisphosphate most effectively. Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation.2 Publications

    Kineticsi

    1. KM=14.3 µM for PtdIns(4,5)P2 (at pH 6.0)1 Publication

    GO - Molecular functioni

    1. phosphoric ester hydrolase activity Source: InterPro

    GO - Biological processi

    1. cardiac muscle hypertrophy in response to stress Source: Ensembl
    2. phosphatidylinositol catabolic process Source: Ensembl
    3. phosphatidylinositol-mediated signaling Source: Ensembl
    4. regulation of protein kinase B signaling Source: Ensembl

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciMetaCyc:HS12255-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidylinositide phosphatase SAC2 (EC:3.1.3.-)
    Alternative name(s):
    Inositol polyphosphate 5-phosphatase F
    Sac domain-containing inositol phosphatase 2
    Sac domain-containing phosphoinositide 5-phosphatase 2
    Short name:
    hSAC2
    Gene namesi
    Name:INPP5F
    Synonyms:KIAA0966, SAC2
    ORF Names:MSTP007, MSTP047
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:17054. INPP5F.

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi460 – 4601D → A: Loss of phosphatase activity. 1 Publication

    Organism-specific databases

    PharmGKBiPA134927878.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11321132Phosphatidylinositide phosphatase SAC2PRO_0000331621Add
    BLAST

    Proteomic databases

    MaxQBiQ9Y2H2.
    PaxDbiQ9Y2H2.
    PRIDEiQ9Y2H2.

    PTM databases

    PhosphoSiteiQ9Y2H2.

    Expressioni

    Tissue specificityi

    Ubiquitous.1 Publication

    Gene expression databases

    ArrayExpressiQ9Y2H2.
    BgeeiQ9Y2H2.
    CleanExiHS_INPP5F.
    GenevestigatoriQ9Y2H2.

    Organism-specific databases

    HPAiHPA042605.

    Interactioni

    Protein-protein interaction databases

    BioGridi116543. 1 interaction.
    IntActiQ9Y2H2. 1 interaction.
    STRINGi9606.ENSP00000354519.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y2H2.
    SMRiQ9Y2H2. Positions 5-520.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini167 – 518352SACPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 SAC domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5329.
    HOVERGENiHBG095361.
    InParanoidiQ9Y2H2.
    OMAiENTGVMD.
    OrthoDBiEOG73803W.
    PhylomeDBiQ9Y2H2.
    TreeFamiTF313543.

    Family and domain databases

    InterProiIPR022158. Inositol_phosphatase.
    IPR002013. Syja_N.
    [Graphical view]
    PfamiPF12456. hSac2. 1 hit.
    PF02383. Syja_N. 1 hit.
    [Graphical view]
    PROSITEiPS50275. SAC. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y2H2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MELFQAKDHY ILQQGERALW CSRRDGGLQL RPATDLLLAW NPICLGLVEG     50
    VIGKIQLHSD LPWWLILIRQ KALVGKLPGD HEVCKVTKIA VLSLSEMEPQ 100
    DLELELCKKH HFGINKPEKI IPSPDDSKFL LKTFTHIKSN VSAPNKKKVK 150
    ESKEKEKLER RLLEELLKMF MDSESFYYSL TYDLTNSVQR QSTGERDGRP 200
    LWQKVDDRFF WNKYMIQDLT EIGTPDVDFW IIPMIQGFVQ IEELVVNYTE 250
    SSDDEKSSPE TPPQESTCVD DIHPRFLVAL ISRRSRHRAG MRYKRRGVDK 300
    NGNVANYVET EQLIHVHNHT LSFVQTRGSV PVFWSQVGYR YNPRPRLDRS 350
    EKETVAYFCA HFEEQLNIYK KQVIINLVDQ AGREKIIGDA YLKQVLLFNN 400
    SHLTYVSFDF HEHCRGMKFE NVQTLTDAIY DIILDMKWCW VDEAGVICKQ 450
    EGIFRVNCMD CLDRTNVVQA AIARVVMEQQ LKKLGVMPPE QPLPVKCNRI 500
    YQIMWANNGD SISRQYAGTA ALKGDFTRTG ERKLAGVMKD GVNSANRYYL 550
    NRFKDAYRQA VIDLMQGIPV TEDLYSIFTK EKEHEALHKE NQRSHQELIS 600
    QLLQSYMKLL LPDDEKFHGG WALIDCDPSL IDATHRDVDV LLLLSNSAYY 650
    VAYYDDEVDK VNQYQRLSLE NLEKIEIGPE PTLFGKPKFS CMRLHYRYKE 700
    ASGYFHTLRA VMRNPEEDGK DTLQCIAEML QITKQAMGSD LPIIEKKLER 750
    KSSKPHEDII GIRSQNQGSL AQGKNFLMSK FSSLNQKVKQ TKSNVNIGNL 800
    RKLGNFTKPE MKVNFLKPNL KVNLWKSDSS LETMENTGVM DKVQAESDGD 850
    MSSDNDSYHS DEFLTNSKSD EDRQLANSLE SVGPIDYVLP SCGIIASAPR 900
    LGSRSQSLSS TDSSVHAPSE ITVAHGSGLG KGQESPLKKS PSAGDVHILT 950
    GFAKPMDIYC HRFVQDAQNK VTHLSETRSV SQQASQERNQ MTNQVSNETQ 1000
    SESTEQTPSR PSQLDVSLSA TGPQFLSVEP AHSVASQKTP TSASSMLELE 1050
    TGLHVTPSPS ESSSSRAVSP FAKIRSSMVQ VASITQAGLT HGINFAVSKV 1100
    QKSPPEPEII NQVQQNELKK MFIQCQTRII QI 1132
    Length:1,132
    Mass (Da):128,407
    Last modified:April 29, 2008 - v3
    Checksum:i853719FC0AD455CD
    GO
    Isoform 2 (identifier: Q9Y2H2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         373-375: VII → QQK
         376-1132: Missing.

    Show »
    Length:375
    Mass (Da):43,817
    Checksum:iE9A76393F10C6CC3
    GO
    Isoform 3 (identifier: Q9Y2H2-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         206-219: DDRFFWNKYMIQDL → PLTARRAGFALGKK
         220-1132: Missing.

    Show »
    Length:219
    Mass (Da):25,174
    Checksum:i8AAA498682414245
    GO
    Isoform 4 (identifier: Q9Y2H2-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-19: MELFQAKDHYILQQGERAL → MCHDVIFMAWLKQQFSECT
         20-629: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:522
    Mass (Da):57,800
    Checksum:i8A15030B00C8E9A1
    GO

    Sequence cautioni

    The sequence BAA76810.2 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti386 – 3861I → V in AAI11494. (PubMed:15489334)Curated
    Sequence conflicti654 – 6541Y → N in BAG52363. (PubMed:14702039)Curated
    Sequence conflicti1008 – 10081P → L in BAG52363. (PubMed:14702039)Curated
    Sequence conflicti1019 – 10191S → P in BAG52363. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti453 – 4531I → V.
    Corresponds to variant rs3736822 [ dbSNP | Ensembl ].
    VAR_042907
    Natural varianti997 – 9971N → D.2 Publications
    Corresponds to variant rs3188055 [ dbSNP | Ensembl ].
    VAR_042908

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1919MELFQ…GERAL → MCHDVIFMAWLKQQFSECT in isoform 4. 1 PublicationVSP_046366Add
    BLAST
    Alternative sequencei20 – 629610Missing in isoform 4. 1 PublicationVSP_046367Add
    BLAST
    Alternative sequencei206 – 21914DDRFF…MIQDL → PLTARRAGFALGKK in isoform 3. 1 PublicationVSP_033266Add
    BLAST
    Alternative sequencei220 – 1132913Missing in isoform 3. 1 PublicationVSP_033267Add
    BLAST
    Alternative sequencei373 – 3753VII → QQK in isoform 2. 1 PublicationVSP_033268
    Alternative sequencei376 – 1132757Missing in isoform 2. 1 PublicationVSP_033269Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB023183 mRNA. Translation: BAA76810.2. Different initiation.
    AK091448 mRNA. Translation: BAG52363.1.
    AC027672 Genomic DNA. No translation available.
    AL133461, AL158014 Genomic DNA. Translation: CAH72974.1.
    AL158014, AL133461 Genomic DNA. Translation: CAI16957.1.
    CH471066 Genomic DNA. Translation: EAW49379.1.
    CH471066 Genomic DNA. Translation: EAW49380.1.
    CH471066 Genomic DNA. Translation: EAW49381.1.
    BC052367 mRNA. Translation: AAH52367.1.
    BC067820 mRNA. Translation: AAH67820.1.
    BC082755 mRNA. Translation: AAH82755.1.
    BC111493 mRNA. Translation: AAI11494.1.
    AL137528 mRNA. Translation: CAB70792.1.
    AF113227 mRNA. Translation: AAG39298.1.
    AF109361 mRNA. Translation: AAQ13509.1.
    CCDSiCCDS58098.1. [Q9Y2H2-4]
    CCDS7616.1. [Q9Y2H2-1]
    PIRiT46372.
    RefSeqiNP_001230123.1. NM_001243194.1. [Q9Y2H2-4]
    NP_001230124.1. NM_001243195.1. [Q9Y2H2-3]
    NP_055752.1. NM_014937.3. [Q9Y2H2-1]
    UniGeneiHs.369755.

    Genome annotation databases

    EnsembliENST00000361976; ENSP00000354519; ENSG00000198825. [Q9Y2H2-1]
    ENST00000369080; ENSP00000358076; ENSG00000198825. [Q9Y2H2-4]
    GeneIDi22876.
    KEGGihsa:22876.
    UCSCiuc001len.4. human. [Q9Y2H2-3]
    uc001leo.3. human. [Q9Y2H2-1]

    Polymorphism databases

    DMDMi187611527.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB023183 mRNA. Translation: BAA76810.2 . Different initiation.
    AK091448 mRNA. Translation: BAG52363.1 .
    AC027672 Genomic DNA. No translation available.
    AL133461 , AL158014 Genomic DNA. Translation: CAH72974.1 .
    AL158014 , AL133461 Genomic DNA. Translation: CAI16957.1 .
    CH471066 Genomic DNA. Translation: EAW49379.1 .
    CH471066 Genomic DNA. Translation: EAW49380.1 .
    CH471066 Genomic DNA. Translation: EAW49381.1 .
    BC052367 mRNA. Translation: AAH52367.1 .
    BC067820 mRNA. Translation: AAH67820.1 .
    BC082755 mRNA. Translation: AAH82755.1 .
    BC111493 mRNA. Translation: AAI11494.1 .
    AL137528 mRNA. Translation: CAB70792.1 .
    AF113227 mRNA. Translation: AAG39298.1 .
    AF109361 mRNA. Translation: AAQ13509.1 .
    CCDSi CCDS58098.1. [Q9Y2H2-4 ]
    CCDS7616.1. [Q9Y2H2-1 ]
    PIRi T46372.
    RefSeqi NP_001230123.1. NM_001243194.1. [Q9Y2H2-4 ]
    NP_001230124.1. NM_001243195.1. [Q9Y2H2-3 ]
    NP_055752.1. NM_014937.3. [Q9Y2H2-1 ]
    UniGenei Hs.369755.

    3D structure databases

    ProteinModelPortali Q9Y2H2.
    SMRi Q9Y2H2. Positions 5-520.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116543. 1 interaction.
    IntActi Q9Y2H2. 1 interaction.
    STRINGi 9606.ENSP00000354519.

    PTM databases

    PhosphoSitei Q9Y2H2.

    Polymorphism databases

    DMDMi 187611527.

    Proteomic databases

    MaxQBi Q9Y2H2.
    PaxDbi Q9Y2H2.
    PRIDEi Q9Y2H2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000361976 ; ENSP00000354519 ; ENSG00000198825 . [Q9Y2H2-1 ]
    ENST00000369080 ; ENSP00000358076 ; ENSG00000198825 . [Q9Y2H2-4 ]
    GeneIDi 22876.
    KEGGi hsa:22876.
    UCSCi uc001len.4. human. [Q9Y2H2-3 ]
    uc001leo.3. human. [Q9Y2H2-1 ]

    Organism-specific databases

    CTDi 22876.
    GeneCardsi GC10P121475.
    HGNCi HGNC:17054. INPP5F.
    HPAi HPA042605.
    MIMi 609389. gene.
    neXtProti NX_Q9Y2H2.
    PharmGKBi PA134927878.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5329.
    HOVERGENi HBG095361.
    InParanoidi Q9Y2H2.
    OMAi ENTGVMD.
    OrthoDBi EOG73803W.
    PhylomeDBi Q9Y2H2.
    TreeFami TF313543.

    Enzyme and pathway databases

    BioCyci MetaCyc:HS12255-MONOMER.

    Miscellaneous databases

    GenomeRNAii 22876.
    NextBioi 35469521.
    PROi Q9Y2H2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y2H2.
    Bgeei Q9Y2H2.
    CleanExi HS_INPP5F.
    Genevestigatori Q9Y2H2.

    Family and domain databases

    InterProi IPR022158. Inositol_phosphatase.
    IPR002013. Syja_N.
    [Graphical view ]
    Pfami PF12456. hSac2. 1 hit.
    PF02383. Syja_N. 1 hit.
    [Graphical view ]
    PROSITEi PS50275. SAC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of a sac domain-containing phosphoinositide 5-phosphatase."
      Minagawa T., Ijuin T., Mochizuki Y., Takenawa T.
      J. Biol. Chem. 276:22011-22015(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, ENZYME ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, MUTAGENESIS OF ASP-460, TISSUE SPECIFICITY.
    2. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASP-997.
      Tissue: Brain.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Brain.
    4. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), VARIANT ASP-997.
      Tissue: Placenta and Skin.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 274-1132 (ISOFORM 1).
      Tissue: Testis.
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 956-1132 (ISOFORM 1).
      Tissue: Aorta.
    9. Cited for: FUNCTION.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSAC2_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y2H2
    Secondary accession number(s): B3KRF1
    , D3DRD1, Q2T9J4, Q5W135, Q5W136, Q6NVY2, Q86U97, Q9H3D9, Q9NT51
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 95 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Inositol polyphosphate 5-phosphatases usually have 2 conserved motifs that are essential for 5-phosphatase activity. However, INPP5F does not contain such motifs, and phosphatase activity seems to exist in the SAC domain, suggesting a new type of phosphoinositide 5-phosphatase.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3