Q9Y2H2 (SAC2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphatidylinositide phosphatase SAC2
EC=3.1.3.-

Alternative name(s):
Inositol polyphosphate 5-phosphatase F
Sac domain-containing inositol phosphatase 2
Sac domain-containing phosphoinositide 5-phosphatase 2
Short name=hSAC2

Gene names

Name:	INPP5F
Synonyms:	KIAA0966, SAC2
ORF Names:	MSTP007, MSTP047

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1132 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Inositol 5-phosphatase which acts on phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Hydrolyzes phosphatidylinositol 4,5-bisphosphate most effectively. Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation. Ref.1 Ref.9
Tissue specificity	Ubiquitous. Ref.1
Miscellaneous	Inositol polyphosphate 5-phosphatases usually have 2 conserved motifs that are essential for 5-phosphatase activity. However, INPP5F does not contain such motifs, and phosphatase activity seems to exist in the SAC domain, suggesting a new type of phosphoinositide 5-phosphatase.
Sequence similarities	Contains 1 SAC domain.
Biophysicochemical properties	Kinetic parameters: KM=14.3 µM for PtdIns(4,5)P2 (at pH 6.0) Ref.1
Sequence caution	The sequence BAA76810.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Molecular function	Hydrolase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cardiac muscle hypertrophy in response to stress Inferred from electronic annotation. Source: Compara phosphatidylinositol catabolic process Inferred from electronic annotation. Source: Compara phosphatidylinositol-mediated signaling Inferred from electronic annotation. Source: Compara
Molecular_function	phosphoric ester hydrolase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9Y2H2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Y2H2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     373-375: VII → QQK
     376-1132: Missing.

Isoform 3 (identifier: Q9Y2H2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     206-219: DDRFFWNKYMIQDL → PLTARRAGFALGKK
     220-1132: Missing.

Isoform 4 (identifier: Q9Y2H2-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: MELFQAKDHYILQQGERAL → MCHDVIFMAWLKQQFSECT
     20-629: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1132	1132	Phosphatidylinositide phosphatase SAC2		PRO_0000331621
Regions
	Domain	167 – 518	352	SAC
Amino acid modifications
	Modified residue	829	1	Phosphoserine By similarity
	Modified residue	905	1	Phosphoserine By similarity
	Modified residue	909	1	Phosphoserine By similarity
	Modified residue	942	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	1 – 19	19	MELFQ…GERAL → MCHDVIFMAWLKQQFSECT in isoform 4.		VSP_046366
	Alternative sequence	20 – 629	610	Missing in isoform 4.		VSP_046367
	Alternative sequence	206 – 219	14	DDRFF…MIQDL → PLTARRAGFALGKK in isoform 3.		VSP_033266
	Alternative sequence	220 – 1132	913	Missing in isoform 3.		VSP_033267
	Alternative sequence	373 – 375	3	VII → QQK in isoform 2.		VSP_033268
	Alternative sequence	376 – 1132	757	Missing in isoform 2.		VSP_033269
	Natural variant	453	1	I → V. Corresponds to variant rs3736822 [ dbSNP | Ensembl ].		VAR_042907
	Natural variant	997	1	N → D. Ref.2 Ref.6 Corresponds to variant rs3188055 [ dbSNP | Ensembl ].		VAR_042908
Experimental info
	Mutagenesis	460	1	D → A: Loss of phosphatase activity. Ref.1
	Sequence conflict	386	1	I → V in AAI11494. Ref.6
	Sequence conflict	654	1	Y → N in BAG52363. Ref.3
	Sequence conflict	1008	1	P → L in BAG52363. Ref.3
	Sequence conflict	1019	1	S → P in BAG52363. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 29, 2008. Version 3. Checksum: 853719FC0AD455CD	FASTA	1,132	128,407
	10 20 30 40 50 60 MELFQAKDHY ILQQGERALW CSRRDGGLQL RPATDLLLAW NPICLGLVEG VIGKIQLHSD 70 80 90 100 110 120 LPWWLILIRQ KALVGKLPGD HEVCKVTKIA VLSLSEMEPQ DLELELCKKH HFGINKPEKI 130 140 150 160 170 180 IPSPDDSKFL LKTFTHIKSN VSAPNKKKVK ESKEKEKLER RLLEELLKMF MDSESFYYSL 190 200 210 220 230 240 TYDLTNSVQR QSTGERDGRP LWQKVDDRFF WNKYMIQDLT EIGTPDVDFW IIPMIQGFVQ 250 260 270 280 290 300 IEELVVNYTE SSDDEKSSPE TPPQESTCVD DIHPRFLVAL ISRRSRHRAG MRYKRRGVDK 310 320 330 340 350 360 NGNVANYVET EQLIHVHNHT LSFVQTRGSV PVFWSQVGYR YNPRPRLDRS EKETVAYFCA 370 380 390 400 410 420 HFEEQLNIYK KQVIINLVDQ AGREKIIGDA YLKQVLLFNN SHLTYVSFDF HEHCRGMKFE 430 440 450 460 470 480 NVQTLTDAIY DIILDMKWCW VDEAGVICKQ EGIFRVNCMD CLDRTNVVQA AIARVVMEQQ 490 500 510 520 530 540 LKKLGVMPPE QPLPVKCNRI YQIMWANNGD SISRQYAGTA ALKGDFTRTG ERKLAGVMKD 550 560 570 580 590 600 GVNSANRYYL NRFKDAYRQA VIDLMQGIPV TEDLYSIFTK EKEHEALHKE NQRSHQELIS 610 620 630 640 650 660 QLLQSYMKLL LPDDEKFHGG WALIDCDPSL IDATHRDVDV LLLLSNSAYY VAYYDDEVDK 670 680 690 700 710 720 VNQYQRLSLE NLEKIEIGPE PTLFGKPKFS CMRLHYRYKE ASGYFHTLRA VMRNPEEDGK 730 740 750 760 770 780 DTLQCIAEML QITKQAMGSD LPIIEKKLER KSSKPHEDII GIRSQNQGSL AQGKNFLMSK 790 800 810 820 830 840 FSSLNQKVKQ TKSNVNIGNL RKLGNFTKPE MKVNFLKPNL KVNLWKSDSS LETMENTGVM 850 860 870 880 890 900 DKVQAESDGD MSSDNDSYHS DEFLTNSKSD EDRQLANSLE SVGPIDYVLP SCGIIASAPR 910 920 930 940 950 960 LGSRSQSLSS TDSSVHAPSE ITVAHGSGLG KGQESPLKKS PSAGDVHILT GFAKPMDIYC 970 980 990 1000 1010 1020 HRFVQDAQNK VTHLSETRSV SQQASQERNQ MTNQVSNETQ SESTEQTPSR PSQLDVSLSA 1030 1040 1050 1060 1070 1080 TGPQFLSVEP AHSVASQKTP TSASSMLELE TGLHVTPSPS ESSSSRAVSP FAKIRSSMVQ 1090 1100 1110 1120 1130 VASITQAGLT HGINFAVSKV QKSPPEPEII NQVQQNELKK MFIQCQTRII QI
	Isoform 2 [UniParc]. Checksum: E9A76393F10C6CC3	FASTA	375	43,817
	10 20 30 40 50 60 MELFQAKDHY ILQQGERALW CSRRDGGLQL RPATDLLLAW NPICLGLVEG VIGKIQLHSD 70 80 90 100 110 120 LPWWLILIRQ KALVGKLPGD HEVCKVTKIA VLSLSEMEPQ DLELELCKKH HFGINKPEKI 130 140 150 160 170 180 IPSPDDSKFL LKTFTHIKSN VSAPNKKKVK ESKEKEKLER RLLEELLKMF MDSESFYYSL 190 200 210 220 230 240 TYDLTNSVQR QSTGERDGRP LWQKVDDRFF WNKYMIQDLT EIGTPDVDFW IIPMIQGFVQ 250 260 270 280 290 300 IEELVVNYTE SSDDEKSSPE TPPQESTCVD DIHPRFLVAL ISRRSRHRAG MRYKRRGVDK 310 320 330 340 350 360 NGNVANYVET EQLIHVHNHT LSFVQTRGSV PVFWSQVGYR YNPRPRLDRS EKETVAYFCA 370 HFEEQLNIYK KQQQK
	Isoform 3 [UniParc]. Checksum: 8AAA498682414245	FASTA	219	25,174
	10 20 30 40 50 60 MELFQAKDHY ILQQGERALW CSRRDGGLQL RPATDLLLAW NPICLGLVEG VIGKIQLHSD 70 80 90 100 110 120 LPWWLILIRQ KALVGKLPGD HEVCKVTKIA VLSLSEMEPQ DLELELCKKH HFGINKPEKI 130 140 150 160 170 180 IPSPDDSKFL LKTFTHIKSN VSAPNKKKVK ESKEKEKLER RLLEELLKMF MDSESFYYSL 190 200 210 TYDLTNSVQR QSTGERDGRP LWQKVPLTAR RAGFALGKK
	Isoform 4 [UniParc]. Checksum: 8A15030B00C8E9A1	FASTA	522	57,800
	10 20 30 40 50 60 MCHDVIFMAW LKQQFSECTL IDATHRDVDV LLLLSNSAYY VAYYDDEVDK VNQYQRLSLE 70 80 90 100 110 120 NLEKIEIGPE PTLFGKPKFS CMRLHYRYKE ASGYFHTLRA VMRNPEEDGK DTLQCIAEML 130 140 150 160 170 180 QITKQAMGSD LPIIEKKLER KSSKPHEDII GIRSQNQGSL AQGKNFLMSK FSSLNQKVKQ 190 200 210 220 230 240 TKSNVNIGNL RKLGNFTKPE MKVNFLKPNL KVNLWKSDSS LETMENTGVM DKVQAESDGD 250 260 270 280 290 300 MSSDNDSYHS DEFLTNSKSD EDRQLANSLE SVGPIDYVLP SCGIIASAPR LGSRSQSLSS 310 320 330 340 350 360 TDSSVHAPSE ITVAHGSGLG KGQESPLKKS PSAGDVHILT GFAKPMDIYC HRFVQDAQNK 370 380 390 400 410 420 VTHLSETRSV SQQASQERNQ MTNQVSNETQ SESTEQTPSR PSQLDVSLSA TGPQFLSVEP 430 440 450 460 470 480 AHSVASQKTP TSASSMLELE TGLHVTPSPS ESSSSRAVSP FAKIRSSMVQ VASITQAGLT 490 500 510 520 HGINFAVSKV QKSPPEPEII NQVQQNELKK MFIQCQTRII QI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characterization of a sac domain-containing phosphoinositide 5-phosphatase." Minagawa T., Ijuin T., Mochizuki Y., Takenawa T. J. Biol. Chem. 276:22011-22015(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, ENZYME ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, MUTAGENESIS OF ASP-460, TISSUE SPECIFICITY.
[2]	"Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASP-997. Tissue: Brain.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Brain.
[4]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), VARIANT ASP-997. Tissue: Placenta and Skin.
[7]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 274-1132 (ISOFORM 1). Tissue: Testis.
[8]	Liu B., Liu Y.Q., Wang X.Y., Zhao B., Sheng H., Zhao X.W., Liu S., Xu Y.Y., Ye J., Song L., Gao Y., Zhang C.L., Zhang J., Wei Y.J., Cao H.Q., Zhao Y., Liu L.S., Ding J.F. , Gao R.L., Wu Q.Y., Qiang B.Q., Yuan J.G., Liew C.C., Zhao M.S., Hui R.T. Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 956-1132 (ISOFORM 1). Tissue: Aorta.
[9]	"Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity." Trivedi C.M., Luo Y., Yin Z., Zhang M., Zhu W., Wang T., Floss T., Goettlicher M., Noppinger P.R., Wurst W., Ferrari V.A., Abrams C.S., Gruber P.J., Epstein J.A. Nat. Med. 13:324-331(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[10]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[11]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.
[12]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB023183 mRNA. Translation: BAA76810.2. Different initiation. AK091448 mRNA. Translation: BAG52363.1. AC027672 Genomic DNA. No translation available. AL133461, AL158014 Genomic DNA. Translation: CAH72974.1. AL158014, AL133461 Genomic DNA. Translation: CAI16957.1. CH471066 Genomic DNA. Translation: EAW49379.1. CH471066 Genomic DNA. Translation: EAW49380.1. CH471066 Genomic DNA. Translation: EAW49381.1. BC052367 mRNA. Translation: AAH52367.1. BC067820 mRNA. Translation: AAH67820.1. BC082755 mRNA. Translation: AAH82755.1. BC111493 mRNA. Translation: AAI11494.1. AL137528 mRNA. Translation: CAB70792.1. AF113227 mRNA. Translation: AAG39298.1. AF109361 mRNA. Translation: AAQ13509.1.
IPI	IPI00383580. IPI00480159. IPI00890685. IPI00890735.
PIR	T46372.
RefSeq	NP_001230124.1. NM_001243195.1. NP_055752.1. NM_014937.3.
UniGene	Hs.369755.
3D structure databases
ProteinModelPortal	Q9Y2H2.
SMR	Q9Y2H2. Positions 5-520.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000354519.
PTM databases
PhosphoSite	Q9Y2H2.
Polymorphism databases
DMDM	187611527.
Proteomic databases
PaxDb	Q9Y2H2.
PRIDE	Q9Y2H2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000361976; ENSP00000354519; ENSG00000198825. ENST00000369080; ENSP00000358076; ENSG00000198825. ENST00000369083; ENSP00000358079; ENSG00000198825.
GeneID	22876.
KEGG	hsa:22876.
UCSC	uc001len.4. human. uc001leo.3. human.
Organism-specific databases
CTD	22876.
GeneCards	GC10P121475.
HGNC	HGNC:17054. INPP5F.
HPA	HPA042605.
MIM	609389. gene.
neXtProt	NX_Q9Y2H2.
PharmGKB	PA134927878.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5329.
HOVERGEN	HBG095361.
InParanoid	Q9Y2H2.
OMA	NFLMSKF.
OrthoDB	EOG4640B6.
Enzyme and pathway databases
BioCyc	MetaCyc:HS12255-MONOMER.
Gene expression databases
ArrayExpress	Q9Y2H2.
Bgee	Q9Y2H2.
CleanEx	HS_INPP5F.
Genevestigator	Q9Y2H2.
Family and domain databases
InterPro	IPR022158. Inositol_phosphatase. IPR002013. Syja_N. [Graphical view]
Pfam	PF12456. hSac2. 1 hit. PF02383. Syja_N. 1 hit. [Graphical view]
PROSITE	PS50275. SAC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	22876.
NextBio	43433.
SOURCE	Search...

Entry information

Entry name

SAC2_HUMAN

Accession

Primary (citable) accession number: Q9Y2H2
Secondary accession number(s): B3KRF1 , D3DRD1, Q2T9J4, Q5W135, Q5W136, Q6NVY2, Q86U97, Q9H3D9, Q9NT51

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	April 29, 2008
Last modified:	May 1, 2013
This is version 81 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.