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Protein

DnaJ homolog subfamily C member 16

Gene

DNAJC16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily C member 16
Gene namesi
Name:DNAJC16
Synonyms:KIAA0962
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000116138.12.
HGNCiHGNC:29157. DNAJC16.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 535CytoplasmicSequence analysisAdd BLAST510
Transmembranei536 – 556Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini557 – 782ExtracellularSequence analysisAdd BLAST226

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000116138.
PharmGKBiPA142671964.

Polymorphism and mutation databases

DMDMi108936027.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000023668326 – 782DnaJ homolog subfamily C member 16Add BLAST757

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi631N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9Y2G8.
PaxDbiQ9Y2G8.
PeptideAtlasiQ9Y2G8.
PRIDEiQ9Y2G8.

PTM databases

iPTMnetiQ9Y2G8.
PhosphoSitePlusiQ9Y2G8.

Expressioni

Gene expression databases

BgeeiENSG00000116138.
CleanExiHS_DNAJC16.
ExpressionAtlasiQ9Y2G8. baseline and differential.
GenevisibleiQ9Y2G8. HS.

Organism-specific databases

HPAiHPA043643.

Interactioni

Protein-protein interaction databases

BioGridi116926. 23 interactors.
IntActiQ9Y2G8. 18 interactors.
STRINGi9606.ENSP00000365007.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2G8.
SMRiQ9Y2G8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 93JPROSITE-ProRule annotationAdd BLAST65
Domaini119 – 247ThioredoxinPROSITE-ProRule annotationAdd BLAST129

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi102 – 107Poly-Gln6
Compositional biasi718 – 721Poly-Glu4

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0715. Eukaryota.
COG0484. LUCA.
GeneTreeiENSGT00840000129767.
HOGENOMiHOG000231877.
HOVERGENiHBG055742.
InParanoidiQ9Y2G8.
KOiK09536.
OMAiSDWCFSC.
OrthoDBiEOG091G06I0.
PhylomeDBiQ9Y2G8.
TreeFamiTF312804.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
InterProiView protein in InterPro
IPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
PfamiView protein in Pfam
PF00226. DnaJ. 1 hit.
PF00085. Thioredoxin. 1 hit.
PRINTSiPR00625. JDOMAIN.
SMARTiView protein in SMART
SM00271. DnaJ. 1 hit.
SUPFAMiSSF46565. SSF46565. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiView protein in PROSITE
PS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y2G8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVRKLSISW QFLIVLVLIL QILSALDFDP YRVLGVSRTA SQADIKKAYK
60 70 80 90 100
KLAREWHPDK NKDPGAEDKF IQISKAYEIL SNEEKRSNYD QYGDAGENQG
110 120 130 140 150
YQKQQQQREY RFRHFHENFY FDESFFHFPF NSERRDSIDE KYLLHFSHYV
160 170 180 190 200
NEVVPDSFKK PYLIKITSDW CFSCIHIEPV WKEVIQELEE LGVGIGVVHA
210 220 230 240 250
GYERRLAHHL GAHSTPSILG IINGKISFFH NAVVRENLRQ FVESLLPGNL
260 270 280 290 300
VEKVTNKNYV RFLSGWQQEN KPHVLLFDQT PIVPLLYKLT AFAYKDYLSF
310 320 330 340 350
GYVYVGLRGT EEMTRRYNIN IYAPTLLVFK EHINRPADVI QARGMKKQII
360 370 380 390 400
DDFITRNKYL LAARLTSQKL FHELCPVKRS HRQRKYCVVL LTAETTKLSK
410 420 430 440 450
PFEAFLSFAL ANTQDTVRFV HVYSNRQQEF ADTLLPDSEA FQGKSAVSIL
460 470 480 490 500
ERRNTAGRVV YKTLEDPWIG SESDKFILLG YLDQLRKDPA LLSSEAVLPD
510 520 530 540 550
LTDELAPVFL LRWFYSASDY ISDCWDSIFH NNWREMMPLL SLIFSALFIL
560 570 580 590 600
FGTVIVQAFS DSNDERESSP PEKEEAQEKT GKTEPSFTKE NSSKIPKKGF
610 620 630 640 650
VEVTELTDVT YTSNLVRLRP GHMNVVLILS NSTKTSLLQK FALEVYTFTG
660 670 680 690 700
SSCLHFSFLS LDKHREWLEY LLEFAQDAAP IPNQYDKHFM ERDYTGYVLA
710 720 730 740 750
LNGHKKYFCL FKPQKTVEEE EAIGSCSDVD SSLYLGESRG KPSCGLGSRP
760 770 780
IKGKLSKLSL WMERLLEGSL QRFYIPSWPE LD
Length:782
Mass (Da):90,591
Last modified:May 30, 2006 - v3
Checksum:i42D564BBC6EED981
GO
Isoform 2 (identifier: Q9Y2G8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-312: Missing.

Show »
Length:470
Mass (Da):53,987
Checksum:i10348C2E083AB384
GO

Sequence cautioni

The sequence BAA76806 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0185831 – 312Missing in isoform 2. 1 PublicationAdd BLAST312

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023179 mRNA. Translation: BAA76806.2. Different initiation.
CR749259 mRNA. Translation: CAH18115.1.
CR749567 mRNA. Translation: CAH18363.1.
AL512883, AL121992 Genomic DNA. Translation: CAI12976.1.
AL121992, AL512883 Genomic DNA. Translation: CAI22371.1.
BC031991 mRNA. Translation: AAH31991.1.
BC047363 mRNA. Translation: AAH47363.1.
CCDSiCCDS30606.1. [Q9Y2G8-1]
CCDS72710.1. [Q9Y2G8-2]
RefSeqiNP_001274740.1. NM_001287811.1. [Q9Y2G8-2]
NP_056106.1. NM_015291.3. [Q9Y2G8-1]
UniGeneiHs.655410.

Genome annotation databases

EnsembliENST00000375847; ENSP00000365007; ENSG00000116138. [Q9Y2G8-1]
ENST00000616884; ENSP00000480224; ENSG00000116138. [Q9Y2G8-2]
GeneIDi23341.
KEGGihsa:23341.
UCSCiuc001aws.4. human. [Q9Y2G8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiDJC16_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2G8
Secondary accession number(s): Q68D57, Q86X32, Q8N5P4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 30, 2006
Last modified: September 27, 2017
This is version 123 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM