Reviewed, UniProtKB/Swiss-Prot Q9Y2G8 (DJC16_HUMAN)

Names and origin

Protein names

Recommended name:
DnaJ homolog subfamily C member 16

Gene names

Name:	DNAJC16
Synonyms:	KIAA0962

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	782 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Membrane; Single-pass type IV membrane protein Potential.
Sequence similarities	Contains 1 J domain. Contains 1 thioredoxin domain.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Signal Transmembrane
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro protein folding Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	heat shock protein binding Inferred from electronic annotation. Source: InterPro unfolded protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9Y2G8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Y2G8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-312: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25	Potential
	Chain	26 – 782	757	DnaJ homolog subfamily C member 16		PRO_0000236683
Regions
	Topological domain	26 – 535	510	Cytoplasmic Potential
	Transmembrane	536 – 556	21	Anchor for type IV membrane protein Potential
	Topological domain	557 – 782	226	Extracellular Potential
	Domain	29 – 93	65	J
	Domain	119 – 247	129	Thioredoxin
	Compositional bias	102 – 107	6	Poly-Gln
	Compositional bias	718 – 721	4	Poly-Glu
Amino acid modifications
	Glycosylation	631	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1 – 312	312	Missing in isoform 2.		VSP_018583

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 30, 2006. Version 3. Checksum: 42D564BBC6EED981	FASTA	782	90,591
	10 20 30 40 50 60 MEVRKLSISW QFLIVLVLIL QILSALDFDP YRVLGVSRTA SQADIKKAYK KLAREWHPDK 70 80 90 100 110 120 NKDPGAEDKF IQISKAYEIL SNEEKRSNYD QYGDAGENQG YQKQQQQREY RFRHFHENFY 130 140 150 160 170 180 FDESFFHFPF NSERRDSIDE KYLLHFSHYV NEVVPDSFKK PYLIKITSDW CFSCIHIEPV 190 200 210 220 230 240 WKEVIQELEE LGVGIGVVHA GYERRLAHHL GAHSTPSILG IINGKISFFH NAVVRENLRQ 250 260 270 280 290 300 FVESLLPGNL VEKVTNKNYV RFLSGWQQEN KPHVLLFDQT PIVPLLYKLT AFAYKDYLSF 310 320 330 340 350 360 GYVYVGLRGT EEMTRRYNIN IYAPTLLVFK EHINRPADVI QARGMKKQII DDFITRNKYL 370 380 390 400 410 420 LAARLTSQKL FHELCPVKRS HRQRKYCVVL LTAETTKLSK PFEAFLSFAL ANTQDTVRFV 430 440 450 460 470 480 HVYSNRQQEF ADTLLPDSEA FQGKSAVSIL ERRNTAGRVV YKTLEDPWIG SESDKFILLG 490 500 510 520 530 540 YLDQLRKDPA LLSSEAVLPD LTDELAPVFL LRWFYSASDY ISDCWDSIFH NNWREMMPLL 550 560 570 580 590 600 SLIFSALFIL FGTVIVQAFS DSNDERESSP PEKEEAQEKT GKTEPSFTKE NSSKIPKKGF 610 620 630 640 650 660 VEVTELTDVT YTSNLVRLRP GHMNVVLILS NSTKTSLLQK FALEVYTFTG SSCLHFSFLS 670 680 690 700 710 720 LDKHREWLEY LLEFAQDAAP IPNQYDKHFM ERDYTGYVLA LNGHKKYFCL FKPQKTVEEE 730 740 750 760 770 780 EAIGSCSDVD SSLYLGESRG KPSCGLGSRP IKGKLSKLSL WMERLLEGSL QRFYIPSWPE LD
	Isoform 2. Checksum: 10348C2E083AB384	FASTA	470	53,987
	10 20 30 40 50 60 MTRRYNINIY APTLLVFKEH INRPADVIQA RGMKKQIIDD FITRNKYLLA ARLTSQKLFH 70 80 90 100 110 120 ELCPVKRSHR QRKYCVVLLT AETTKLSKPF EAFLSFALAN TQDTVRFVHV YSNRQQEFAD 130 140 150 160 170 180 TLLPDSEAFQ GKSAVSILER RNTAGRVVYK TLEDPWIGSE SDKFILLGYL DQLRKDPALL 190 200 210 220 230 240 SSEAVLPDLT DELAPVFLLR WFYSASDYIS DCWDSIFHNN WREMMPLLSL IFSALFILFG 250 260 270 280 290 300 TVIVQAFSDS NDERESSPPE KEEAQEKTGK TEPSFTKENS SKIPKKGFVE VTELTDVTYT 310 320 330 340 350 360 SNLVRLRPGH MNVVLILSNS TKTSLLQKFA LEVYTFTGSS CLHFSFLSLD KHREWLEYLL 370 380 390 400 410 420 EFAQDAAPIP NQYDKHFMER DYTGYVLALN GHKKYFCLFK PQKTVEEEEA IGSCSDVDSS 430 440 450 460 470 LYLGESRGKP SCGLGSRPIK GKLSKLSLWM ERLLEGSLQR FYIPSWPELD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 6:63-70(1999) [PubMed: 10231032] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[2]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed: 12168954] [Abstract] Cited for: SEQUENCE REVISION.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Retina.
[4]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Skin and Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB023179 mRNA. Translation: BAA76806.2. Different initiation. CR749259 mRNA. Translation: CAH18115.1. CR749567 mRNA. Translation: CAH18363.1. AL512883, AL121992 Genomic DNA. Translation: CAI12976.1. AL121992, AL512883 Genomic DNA. Translation: CAI22371.1. BC031991 mRNA. Translation: AAH31991.1. BC047363 mRNA. Translation: AAH47363.1.
IPI	IPI00006433. IPI00759581.
RefSeq	NP_056106.1.
UniGene	Hs.655410
3D structure databases
SMR	Q9Y2G8. Positions 19-100, 27-176, 160-434.
ModBase	Search...
Proteomic databases
PRIDE	Q9Y2G8.
Genome annotation databases
Ensembl	ENST00000375847; ENSP00000365007; ENSG00000116138; Homo sapiens. [Genome view]
GeneID	23341.
KEGG	hsa:23341.
UCSC	uc001aws.1. human. uc001awt.1. human.
Organism-specific databases
CTD	23341.
GeneCards	GC01P015725.
H-InvDB	HIX0000154.
HGNC	HGNC:29157. DNAJC16.
PharmGKB	PA142671964.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG445587.
HOVERGEN	HBG055742.
InParanoid	Q9Y2G8.
OMA	KLTAFAY.
Gene expression databases
ArrayExpress	Q9Y2G8.
Bgee	Q9Y2G8.
CleanEx	HS_DNAJC16.
Genevestigator	Q9Y2G8.
GermOnline	ENSG00000116138. Homo sapiens.
Family and domain databases
InterPro	IPR001623. DnaJ_N. IPR018253. Heat_shock_DnaJ_CS. IPR015609. Hsp40/DnaJ_Rel. IPR003095. Hsp_DnaJ. IPR017936. Thioredoxin-like. IPR012336. Thioredoxin-like_fold. IPR013766. Thioredoxin_domain. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:1.10.287.110. DnaJ_N. 1 hit. G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PANTHER	PTHR11821. Hsp40/DnaJ_Rel. 1 hit.
Pfam	PF00226. DnaJ. 1 hit. PF00085. Thioredoxin. 1 hit. [Graphical view]
PRINTS	PR00625. DNAJPROTEIN.
SMART	SM00271. DnaJ. 1 hit. [Graphical view]
SUPFAM	SSF46565. DnaJ_N. 1 hit. SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS00636. DNAJ_1. 1 hit. PS50076. DNAJ_2. 1 hit. PS51352. THIOREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	45297.

Entry information

Entry name

DJC16_HUMAN

Accession

Primary (citable) accession number: Q9Y2G8
Secondary accession number(s): Q68D57, Q86X32, Q8N5P4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	May 30, 2006
Last modified:	March 2, 2010
This is version 64 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.