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Protein

DnaJ homolog subfamily C member 16

Gene

DNAJC16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily C member 16
Gene namesi
Name:DNAJC16
Synonyms:KIAA0962
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:29157. DNAJC16.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 535510CytoplasmicSequence analysisAdd
BLAST
Transmembranei536 – 55621Helical; Anchor for type IV membrane proteinSequence analysisAdd
BLAST
Topological domaini557 – 782226ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671964.

Polymorphism and mutation databases

DMDMi108936027.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 782757DnaJ homolog subfamily C member 16PRO_0000236683Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi631 – 6311N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9Y2G8.
MaxQBiQ9Y2G8.
PaxDbiQ9Y2G8.
PRIDEiQ9Y2G8.

PTM databases

iPTMnetiQ9Y2G8.
PhosphoSiteiQ9Y2G8.

Expressioni

Gene expression databases

BgeeiQ9Y2G8.
CleanExiHS_DNAJC16.
ExpressionAtlasiQ9Y2G8. baseline and differential.
GenevisibleiQ9Y2G8. HS.

Organism-specific databases

HPAiHPA043643.

Interactioni

Protein-protein interaction databases

BioGridi116926. 8 interactions.
IntActiQ9Y2G8. 2 interactions.
STRINGi9606.ENSP00000365007.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2G8.
SMRiQ9Y2G8. Positions 19-232.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 9365JPROSITE-ProRule annotationAdd
BLAST
Domaini119 – 247129ThioredoxinPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi102 – 1076Poly-Gln
Compositional biasi718 – 7214Poly-Glu

Sequence similaritiesi

Contains 1 J domain.PROSITE-ProRule annotation
Contains 1 thioredoxin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0715. Eukaryota.
COG0484. LUCA.
GeneTreeiENSGT00840000129833.
HOGENOMiHOG000231877.
HOVERGENiHBG055742.
InParanoidiQ9Y2G8.
KOiK09536.
OMAiNTQDTVR.
OrthoDBiEOG718KBH.
PhylomeDBiQ9Y2G8.
TreeFamiTF312804.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y2G8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVRKLSISW QFLIVLVLIL QILSALDFDP YRVLGVSRTA SQADIKKAYK
60 70 80 90 100
KLAREWHPDK NKDPGAEDKF IQISKAYEIL SNEEKRSNYD QYGDAGENQG
110 120 130 140 150
YQKQQQQREY RFRHFHENFY FDESFFHFPF NSERRDSIDE KYLLHFSHYV
160 170 180 190 200
NEVVPDSFKK PYLIKITSDW CFSCIHIEPV WKEVIQELEE LGVGIGVVHA
210 220 230 240 250
GYERRLAHHL GAHSTPSILG IINGKISFFH NAVVRENLRQ FVESLLPGNL
260 270 280 290 300
VEKVTNKNYV RFLSGWQQEN KPHVLLFDQT PIVPLLYKLT AFAYKDYLSF
310 320 330 340 350
GYVYVGLRGT EEMTRRYNIN IYAPTLLVFK EHINRPADVI QARGMKKQII
360 370 380 390 400
DDFITRNKYL LAARLTSQKL FHELCPVKRS HRQRKYCVVL LTAETTKLSK
410 420 430 440 450
PFEAFLSFAL ANTQDTVRFV HVYSNRQQEF ADTLLPDSEA FQGKSAVSIL
460 470 480 490 500
ERRNTAGRVV YKTLEDPWIG SESDKFILLG YLDQLRKDPA LLSSEAVLPD
510 520 530 540 550
LTDELAPVFL LRWFYSASDY ISDCWDSIFH NNWREMMPLL SLIFSALFIL
560 570 580 590 600
FGTVIVQAFS DSNDERESSP PEKEEAQEKT GKTEPSFTKE NSSKIPKKGF
610 620 630 640 650
VEVTELTDVT YTSNLVRLRP GHMNVVLILS NSTKTSLLQK FALEVYTFTG
660 670 680 690 700
SSCLHFSFLS LDKHREWLEY LLEFAQDAAP IPNQYDKHFM ERDYTGYVLA
710 720 730 740 750
LNGHKKYFCL FKPQKTVEEE EAIGSCSDVD SSLYLGESRG KPSCGLGSRP
760 770 780
IKGKLSKLSL WMERLLEGSL QRFYIPSWPE LD
Length:782
Mass (Da):90,591
Last modified:May 30, 2006 - v3
Checksum:i42D564BBC6EED981
GO
Isoform 2 (identifier: Q9Y2G8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-312: Missing.

Show »
Length:470
Mass (Da):53,987
Checksum:i10348C2E083AB384
GO

Sequence cautioni

The sequence BAA76806.2 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 312312Missing in isoform 2. 1 PublicationVSP_018583Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023179 mRNA. Translation: BAA76806.2. Different initiation.
CR749259 mRNA. Translation: CAH18115.1.
CR749567 mRNA. Translation: CAH18363.1.
AL512883, AL121992 Genomic DNA. Translation: CAI12976.1.
AL121992, AL512883 Genomic DNA. Translation: CAI22371.1.
BC031991 mRNA. Translation: AAH31991.1.
BC047363 mRNA. Translation: AAH47363.1.
CCDSiCCDS30606.1. [Q9Y2G8-1]
CCDS72710.1. [Q9Y2G8-2]
RefSeqiNP_001274740.1. NM_001287811.1. [Q9Y2G8-2]
NP_056106.1. NM_015291.3. [Q9Y2G8-1]
UniGeneiHs.655410.

Genome annotation databases

EnsembliENST00000375847; ENSP00000365007; ENSG00000116138. [Q9Y2G8-1]
ENST00000616884; ENSP00000480224; ENSG00000116138. [Q9Y2G8-2]
GeneIDi23341.
KEGGihsa:23341.
UCSCiuc001aws.4. human. [Q9Y2G8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023179 mRNA. Translation: BAA76806.2. Different initiation.
CR749259 mRNA. Translation: CAH18115.1.
CR749567 mRNA. Translation: CAH18363.1.
AL512883, AL121992 Genomic DNA. Translation: CAI12976.1.
AL121992, AL512883 Genomic DNA. Translation: CAI22371.1.
BC031991 mRNA. Translation: AAH31991.1.
BC047363 mRNA. Translation: AAH47363.1.
CCDSiCCDS30606.1. [Q9Y2G8-1]
CCDS72710.1. [Q9Y2G8-2]
RefSeqiNP_001274740.1. NM_001287811.1. [Q9Y2G8-2]
NP_056106.1. NM_015291.3. [Q9Y2G8-1]
UniGeneiHs.655410.

3D structure databases

ProteinModelPortaliQ9Y2G8.
SMRiQ9Y2G8. Positions 19-232.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116926. 8 interactions.
IntActiQ9Y2G8. 2 interactions.
STRINGi9606.ENSP00000365007.

PTM databases

iPTMnetiQ9Y2G8.
PhosphoSiteiQ9Y2G8.

Polymorphism and mutation databases

DMDMi108936027.

Proteomic databases

EPDiQ9Y2G8.
MaxQBiQ9Y2G8.
PaxDbiQ9Y2G8.
PRIDEiQ9Y2G8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375847; ENSP00000365007; ENSG00000116138. [Q9Y2G8-1]
ENST00000616884; ENSP00000480224; ENSG00000116138. [Q9Y2G8-2]
GeneIDi23341.
KEGGihsa:23341.
UCSCiuc001aws.4. human. [Q9Y2G8-1]

Organism-specific databases

CTDi23341.
GeneCardsiDNAJC16.
HGNCiHGNC:29157. DNAJC16.
HPAiHPA043643.
neXtProtiNX_Q9Y2G8.
PharmGKBiPA142671964.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0715. Eukaryota.
COG0484. LUCA.
GeneTreeiENSGT00840000129833.
HOGENOMiHOG000231877.
HOVERGENiHBG055742.
InParanoidiQ9Y2G8.
KOiK09536.
OMAiNTQDTVR.
OrthoDBiEOG718KBH.
PhylomeDBiQ9Y2G8.
TreeFamiTF312804.

Miscellaneous databases

GenomeRNAii23341.
NextBioi45297.
PROiQ9Y2G8.

Gene expression databases

BgeeiQ9Y2G8.
CleanExiHS_DNAJC16.
ExpressionAtlasiQ9Y2G8. baseline and differential.
GenevisibleiQ9Y2G8. HS.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Retina.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Skin and Testis.

Entry informationi

Entry nameiDJC16_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2G8
Secondary accession number(s): Q68D57, Q86X32, Q8N5P4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 30, 2006
Last modified: May 11, 2016
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.