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Protein

Zinc finger protein 30 homolog

Gene

ZFP30

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri158 – 180C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri186 – 208C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri214 – 236C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri242 – 264C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 488C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri494 – 516C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 30 homolog
Short name:
Zfp-30
Alternative name(s):
Zinc finger protein 745
Gene namesi
Name:ZFP30
Synonyms:KIAA0961, ZNF745
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:29555. ZFP30.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi22835.
OpenTargetsiENSG00000120784.
PharmGKBiPA143485675.

Polymorphism and mutation databases

BioMutaiZFP30.
DMDMi6686181.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000472911 – 519Zinc finger protein 30 homologAdd BLAST519

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei75Asymmetric dimethylarginineBy similarity1
Cross-linki110Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki141Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Methylation, Ubl conjugation

Proteomic databases

EPDiQ9Y2G7.
MaxQBiQ9Y2G7.
PaxDbiQ9Y2G7.
PeptideAtlasiQ9Y2G7.
PRIDEiQ9Y2G7.

PTM databases

iPTMnetiQ9Y2G7.
PhosphoSitePlusiQ9Y2G7.

Expressioni

Gene expression databases

BgeeiENSG00000120784.
CleanExiHS_ZFP30.
ExpressionAtlasiQ9Y2G7. baseline and differential.
GenevisibleiQ9Y2G7. HS.

Organism-specific databases

HPAiHPA030606.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000343581.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2G7.
SMRiQ9Y2G7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 78KRABPROSITE-ProRule annotationAdd BLAST73

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri158 – 180C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri186 – 208C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri214 – 236C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri242 – 264C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 488C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri494 – 516C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129704.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9Y2G7.
KOiK09228.
OMAiYQRIHNR.
OrthoDBiEOG091G02KC.
PhylomeDBiQ9Y2G7.
TreeFamiTF341817.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR013087. Znf_C2H2_type.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF57667. SSF57667. 7 hits.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.

Sequencei

Sequence statusi: Complete.

Q9Y2G7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARDLVMFRD VAVDFSQEEW ECLNSYQRNL YRDVILENYS NLVSLAGCSI
60 70 80 90 100
SKPDVITLLE QGKEPWMVVR DEKRRWTLDL ESRYDTKKLF QGKDIYEMNL
110 120 130 140 150
SQWKVMERIK SCGLEEQESP HEVCFRQVTK TTSEKMPTYR KLTSLPLYQK
160 170 180 190 200
SHNREKPYEC GECGKAFRVR QQLTFHQRIH TGEKPYECKE CGKAFRQCAH
210 220 230 240 250
LSRHQRIHTS DKLYECKKCG KIFTCGSDLR VHQRIHIGEK PYECKECGKA
260 270 280 290 300
FRVRGQLNLH QRIHTGEKPY ECKECGKAFR QYAHLTRHQR LNIAEKCYEC
310 320 330 340 350
KECGQAFLCS TGLRLHHKLH TGEKPYECKE CGKAFRVRQQ LTLHQRIHTG
360 370 380 390 400
EKPYDCKECG KTFSRGYHLT LHQRIHTGEK PYECKECQKF FRRYSELISH
410 420 430 440 450
QGIHIGEKPY ECKECGKAFR LFSQLTQHQS IHFGEKPFKC KECEKTFRLL
460 470 480 490 500
SQLTQHQSIH TGEKPYDCKE CGKAFRLHSS LIQHQRIHSG EKPYKCKECK
510
KAFRQHSHLT YHQRIHNVT
Length:519
Mass (Da):61,558
Last modified:November 1, 1999 - v1
Checksum:iA0903F75E3B1C320
GO

Sequence cautioni

The sequence BAA76805 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023178 mRNA. Translation: BAA76805.2. Different initiation.
BC041087 mRNA. Translation: AAH41087.1.
CCDSiCCDS33005.1.
RefSeqiNP_001307595.1. NM_001320666.1.
NP_001307596.1. NM_001320667.1.
NP_001307597.1. NM_001320668.1.
NP_001307598.1. NM_001320669.1.
NP_055713.1. NM_014898.2.
UniGeneiHs.716719.
Hs.722657.

Genome annotation databases

EnsembliENST00000351218; ENSP00000343581; ENSG00000120784.
ENST00000392144; ENSP00000375988; ENSG00000120784.
ENST00000514101; ENSP00000422930; ENSG00000120784.
GeneIDi22835.
KEGGihsa:22835.
UCSCiuc002ogx.2. human.

Similar proteinsi

Entry informationi

Entry nameiZFP30_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2G7
Secondary accession number(s): Q58EY8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: August 30, 2017
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families