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Protein

Zinc finger protein 30 homolog

Gene

ZFP30

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri158 – 18023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri186 – 20823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri214 – 23623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri242 – 26423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri270 – 29223C2H2-type 5; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri298 – 32023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri326 – 34823C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri354 – 37623C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri382 – 40423C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri410 – 43223C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri438 – 46023C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri466 – 48823C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri494 – 51623C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: GO_Central

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: GO_Central
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 30 homolog
Short name:
Zfp-30
Alternative name(s):
Zinc finger protein 745
Gene namesi
Name:ZFP30
Synonyms:KIAA0961, ZNF745
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:29555. ZFP30.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485675.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 519519Zinc finger protein 30 homologPRO_0000047291Add
BLAST

Proteomic databases

PaxDbiQ9Y2G7.
PRIDEiQ9Y2G7.

PTM databases

PhosphoSiteiQ9Y2G7.

Expressioni

Gene expression databases

BgeeiQ9Y2G7.
CleanExiHS_ZFP30.
ExpressionAtlasiQ9Y2G7. baseline and differential.
GenevestigatoriQ9Y2G7.

Organism-specific databases

HPAiHPA030606.

Interactioni

Protein-protein interaction databases

BioGridi116509. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2G7.
SMRiQ9Y2G7. Positions 145-493.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 7873KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri158 – 18023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri186 – 20823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri214 – 23623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri242 – 26423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri270 – 29223C2H2-type 5; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri298 – 32023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri326 – 34823C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri354 – 37623C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri382 – 40423C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri410 – 43223C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri438 – 46023C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri466 – 48823C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri494 – 51623C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00780000121862.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9Y2G7.
KOiK09228.
OMAiGLEGQES.
PhylomeDBiQ9Y2G7.
TreeFamiTF341817.

Family and domain databases

Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y2G7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARDLVMFRD VAVDFSQEEW ECLNSYQRNL YRDVILENYS NLVSLAGCSI
60 70 80 90 100
SKPDVITLLE QGKEPWMVVR DEKRRWTLDL ESRYDTKKLF QGKDIYEMNL
110 120 130 140 150
SQWKVMERIK SCGLEEQESP HEVCFRQVTK TTSEKMPTYR KLTSLPLYQK
160 170 180 190 200
SHNREKPYEC GECGKAFRVR QQLTFHQRIH TGEKPYECKE CGKAFRQCAH
210 220 230 240 250
LSRHQRIHTS DKLYECKKCG KIFTCGSDLR VHQRIHIGEK PYECKECGKA
260 270 280 290 300
FRVRGQLNLH QRIHTGEKPY ECKECGKAFR QYAHLTRHQR LNIAEKCYEC
310 320 330 340 350
KECGQAFLCS TGLRLHHKLH TGEKPYECKE CGKAFRVRQQ LTLHQRIHTG
360 370 380 390 400
EKPYDCKECG KTFSRGYHLT LHQRIHTGEK PYECKECQKF FRRYSELISH
410 420 430 440 450
QGIHIGEKPY ECKECGKAFR LFSQLTQHQS IHFGEKPFKC KECEKTFRLL
460 470 480 490 500
SQLTQHQSIH TGEKPYDCKE CGKAFRLHSS LIQHQRIHSG EKPYKCKECK
510
KAFRQHSHLT YHQRIHNVT
Length:519
Mass (Da):61,558
Last modified:November 1, 1999 - v1
Checksum:iA0903F75E3B1C320
GO

Sequence cautioni

The sequence BAA76805.2 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023178 mRNA. Translation: BAA76805.2. Different initiation.
BC041087 mRNA. Translation: AAH41087.1.
CCDSiCCDS33005.1.
RefSeqiNP_055713.1. NM_014898.2.
XP_006723152.1. XM_006723089.1.
UniGeneiHs.716719.
Hs.722657.

Genome annotation databases

EnsembliENST00000351218; ENSP00000343581; ENSG00000120784.
ENST00000392144; ENSP00000375988; ENSG00000120784.
ENST00000514101; ENSP00000422930; ENSG00000120784.
GeneIDi22835.
KEGGihsa:22835.
UCSCiuc002ogv.1. human.

Polymorphism databases

DMDMi6686181.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023178 mRNA. Translation: BAA76805.2. Different initiation.
BC041087 mRNA. Translation: AAH41087.1.
CCDSiCCDS33005.1.
RefSeqiNP_055713.1. NM_014898.2.
XP_006723152.1. XM_006723089.1.
UniGeneiHs.716719.
Hs.722657.

3D structure databases

ProteinModelPortaliQ9Y2G7.
SMRiQ9Y2G7. Positions 145-493.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116509. 1 interaction.

PTM databases

PhosphoSiteiQ9Y2G7.

Polymorphism databases

DMDMi6686181.

Proteomic databases

PaxDbiQ9Y2G7.
PRIDEiQ9Y2G7.

Protocols and materials databases

DNASUi22835.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000351218; ENSP00000343581; ENSG00000120784.
ENST00000392144; ENSP00000375988; ENSG00000120784.
ENST00000514101; ENSP00000422930; ENSG00000120784.
GeneIDi22835.
KEGGihsa:22835.
UCSCiuc002ogv.1. human.

Organism-specific databases

CTDi22835.
GeneCardsiGC19M038123.
HGNCiHGNC:29555. ZFP30.
HPAiHPA030606.
neXtProtiNX_Q9Y2G7.
PharmGKBiPA143485675.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00780000121862.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9Y2G7.
KOiK09228.
OMAiGLEGQES.
PhylomeDBiQ9Y2G7.
TreeFamiTF341817.

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii22835.
NextBioi43265.
PROiQ9Y2G7.

Gene expression databases

BgeeiQ9Y2G7.
CleanExiHS_ZFP30.
ExpressionAtlasiQ9Y2G7. baseline and differential.
GenevestigatoriQ9Y2G7.

Family and domain databases

Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.

Entry informationi

Entry nameiZFP30_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2G7
Secondary accession number(s): Q58EY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: February 4, 2015
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.