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Q9Y2G7 (ZFP30_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 30 homolog

Short name=Zfp-30
Alternative name(s):
Zinc finger protein 745
Gene names
Name:ZFP30
Synonyms:KIAA0961, ZNF745
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length519 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Potential.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 13 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Sequence caution

The sequence BAA76805.2 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 519519Zinc finger protein 30 homolog
PRO_0000047291

Regions

Domain6 – 7873KRAB
Zinc finger158 – 18023C2H2-type 1
Zinc finger186 – 20823C2H2-type 2
Zinc finger214 – 23623C2H2-type 3
Zinc finger242 – 26423C2H2-type 4
Zinc finger270 – 29223C2H2-type 5; degenerate
Zinc finger298 – 32023C2H2-type 6
Zinc finger326 – 34823C2H2-type 7
Zinc finger354 – 37623C2H2-type 8
Zinc finger382 – 40423C2H2-type 9
Zinc finger410 – 43223C2H2-type 10
Zinc finger438 – 46023C2H2-type 11
Zinc finger466 – 48823C2H2-type 12
Zinc finger494 – 51623C2H2-type 13

Sequences

Sequence LengthMass (Da)Tools
Q9Y2G7 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: A0903F75E3B1C320

FASTA51961,558
        10         20         30         40         50         60 
MARDLVMFRD VAVDFSQEEW ECLNSYQRNL YRDVILENYS NLVSLAGCSI SKPDVITLLE 

        70         80         90        100        110        120 
QGKEPWMVVR DEKRRWTLDL ESRYDTKKLF QGKDIYEMNL SQWKVMERIK SCGLEEQESP 

       130        140        150        160        170        180 
HEVCFRQVTK TTSEKMPTYR KLTSLPLYQK SHNREKPYEC GECGKAFRVR QQLTFHQRIH 

       190        200        210        220        230        240 
TGEKPYECKE CGKAFRQCAH LSRHQRIHTS DKLYECKKCG KIFTCGSDLR VHQRIHIGEK 

       250        260        270        280        290        300 
PYECKECGKA FRVRGQLNLH QRIHTGEKPY ECKECGKAFR QYAHLTRHQR LNIAEKCYEC 

       310        320        330        340        350        360 
KECGQAFLCS TGLRLHHKLH TGEKPYECKE CGKAFRVRQQ LTLHQRIHTG EKPYDCKECG 

       370        380        390        400        410        420 
KTFSRGYHLT LHQRIHTGEK PYECKECQKF FRRYSELISH QGIHIGEKPY ECKECGKAFR 

       430        440        450        460        470        480 
LFSQLTQHQS IHFGEKPFKC KECEKTFRLL SQLTQHQSIH TGEKPYDCKE CGKAFRLHSS 

       490        500        510 
LIQHQRIHSG EKPYKCKECK KAFRQHSHLT YHQRIHNVT 

« Hide

References

[1]"Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB023178 mRNA. Translation: BAA76805.2. Different initiation.
BC041087 mRNA. Translation: AAH41087.1.
CCDSCCDS33005.1.
RefSeqNP_055713.1. NM_014898.2.
XP_006723152.1. XM_006723089.1.
UniGeneHs.716719.
Hs.722657.

3D structure databases

ProteinModelPortalQ9Y2G7.
SMRQ9Y2G7. Positions 145-516.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116509. 2 interactions.

PTM databases

PhosphoSiteQ9Y2G7.

Polymorphism databases

DMDM6686181.

Proteomic databases

PaxDbQ9Y2G7.
PRIDEQ9Y2G7.

Protocols and materials databases

DNASU22835.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000351218; ENSP00000343581; ENSG00000120784.
ENST00000392144; ENSP00000375988; ENSG00000120784.
ENST00000514101; ENSP00000422930; ENSG00000120784.
GeneID22835.
KEGGhsa:22835.
UCSCuc002ogv.1. human.

Organism-specific databases

CTD22835.
GeneCardsGC19M038123.
HGNCHGNC:29555. ZFP30.
HPAHPA030606.
neXtProtNX_Q9Y2G7.
PharmGKBPA143485675.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234617.
HOVERGENHBG018163.
InParanoidQ9Y2G7.
KOK09228.
OMAGLEGQES.
PhylomeDBQ9Y2G7.
TreeFamTF341817.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

ArrayExpressQ9Y2G7.
BgeeQ9Y2G7.
CleanExHS_ZFP30.
GenevestigatorQ9Y2G7.

Family and domain databases

Gene3D3.30.160.60. 13 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi22835.
NextBio43265.
PROQ9Y2G7.

Entry information

Entry nameZFP30_HUMAN
AccessionPrimary (citable) accession number: Q9Y2G7
Secondary accession number(s): Q58EY8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM