Q9Y2G7 (ZFP30_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 30 homolog
Short name=Zfp-30

Alternative name(s):
Zinc finger protein 745

Gene names

Name:	ZFP30
Synonyms:	KIAA0961, ZNF745

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	519 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus Potential.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 13 C2H2-type zinc fingers. Contains 1 KRAB domain.
Sequence caution	The sequence BAA76805.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 519	519	Zinc finger protein 30 homolog		PRO_0000047291
Regions
	Domain	6 – 78	73	KRAB
	Zinc finger	158 – 180	23	C2H2-type 1
	Zinc finger	186 – 208	23	C2H2-type 2
	Zinc finger	214 – 236	23	C2H2-type 3
	Zinc finger	242 – 264	23	C2H2-type 4
	Zinc finger	270 – 292	23	C2H2-type 5; degenerate
	Zinc finger	298 – 320	23	C2H2-type 6
	Zinc finger	326 – 348	23	C2H2-type 7
	Zinc finger	354 – 376	23	C2H2-type 8
	Zinc finger	382 – 404	23	C2H2-type 9
	Zinc finger	410 – 432	23	C2H2-type 10
	Zinc finger	438 – 460	23	C2H2-type 11
	Zinc finger	466 – 488	23	C2H2-type 12
	Zinc finger	494 – 516	23	C2H2-type 13

Sequences

	Sequence		Length	Mass (Da)
	Q9Y2G7 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: A0903F75E3B1C320	FASTA	519	61,558
	10 20 30 40 50 60 MARDLVMFRD VAVDFSQEEW ECLNSYQRNL YRDVILENYS NLVSLAGCSI SKPDVITLLE 70 80 90 100 110 120 QGKEPWMVVR DEKRRWTLDL ESRYDTKKLF QGKDIYEMNL SQWKVMERIK SCGLEEQESP 130 140 150 160 170 180 HEVCFRQVTK TTSEKMPTYR KLTSLPLYQK SHNREKPYEC GECGKAFRVR QQLTFHQRIH 190 200 210 220 230 240 TGEKPYECKE CGKAFRQCAH LSRHQRIHTS DKLYECKKCG KIFTCGSDLR VHQRIHIGEK 250 260 270 280 290 300 PYECKECGKA FRVRGQLNLH QRIHTGEKPY ECKECGKAFR QYAHLTRHQR LNIAEKCYEC 310 320 330 340 350 360 KECGQAFLCS TGLRLHHKLH TGEKPYECKE CGKAFRVRQQ LTLHQRIHTG EKPYDCKECG 370 380 390 400 410 420 KTFSRGYHLT LHQRIHTGEK PYECKECQKF FRRYSELISH QGIHIGEKPY ECKECGKAFR 430 440 450 460 470 480 LFSQLTQHQS IHFGEKPFKC KECEKTFRLL SQLTQHQSIH TGEKPYDCKE CGKAFRLHSS 490 500 510 LIQHQRIHSG EKPYKCKECK KAFRQHSHLT YHQRIHNVT

References

[1]	"Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB023178 mRNA. Translation: BAA76805.2. Different initiation. BC041087 mRNA. Translation: AAH41087.1.
IPI	IPI00032142.
RefSeq	NP_055713.1. NM_014898.2.
UniGene	Hs.716719. Hs.722657.
3D structure databases
ProteinModelPortal	Q9Y2G7.
ModBase	Search...
PTM databases
PhosphoSite	Q9Y2G7.
Polymorphism databases
DMDM	6686181.
Proteomic databases
PaxDb	Q9Y2G7.
PRIDE	Q9Y2G7.
Protocols and materials databases
DNASU	22835.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000351218; ENSP00000343581; ENSG00000120784. ENST00000392144; ENSP00000375988; ENSG00000120784. ENST00000514101; ENSP00000422930; ENSG00000120784.
GeneID	22835.
KEGG	hsa:22835.
UCSC	uc002ogv.1. human.
Organism-specific databases
CTD	22835.
GeneCards	GC19M038123.
HGNC	HGNC:29555. ZFP30.
HPA	HPA030606.
neXtProt	NX_Q9Y2G7.
PharmGKB	PA143485675.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000234617.
HOVERGEN	HBG018163.
InParanoid	Q9Y2G7.
KO	K09228.
OMA	NLSQWEI.
OrthoDB	EOG43FGWH.
PhylomeDB	Q9Y2G7.
Gene expression databases
ArrayExpress	Q9Y2G7.
Bgee	Q9Y2G7.
CleanEx	HS_ZFP30.
Genevestigator	Q9Y2G7.
GermOnline	ENSG00000120784. Homo sapiens.
Family and domain databases
Gene3D	3.30.160.60. 13 hits.
InterPro	IPR001909. Krueppel-associated_box. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF01352. KRAB. 1 hit. [Graphical view]
SMART	SM00349. KRAB. 1 hit. SM00355. ZnF_C2H2. 13 hits. [Graphical view]
SUPFAM	SSF109640. Krueppel-associated_box. 1 hit.
PROSITE	PS50805. KRAB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 12 hits. PS50157. ZINC_FINGER_C2H2_2. 13 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	22835.
NextBio	43265.

Entry information

Entry name

ZFP30_HUMAN

Accession

Primary (citable) accession number: Q9Y2G7
Secondary accession number(s): Q58EY8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 112 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.