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Q9Y2G7

- ZFP30_HUMAN

UniProt

Q9Y2G7 - ZFP30_HUMAN

Protein

Zinc finger protein 30 homolog

Gene

ZFP30

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri158 – 18023C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri186 – 20823C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri214 – 23623C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri242 – 26423C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri270 – 29223C2H2-type 5; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri298 – 32023C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri326 – 34823C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri354 – 37623C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri382 – 40423C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri410 – 43223C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri438 – 46023C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri466 – 48823C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri494 – 51623C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. sequence-specific DNA binding transcription factor activity Source: RefGenome

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: RefGenome
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 30 homolog
    Short name:
    Zfp-30
    Alternative name(s):
    Zinc finger protein 745
    Gene namesi
    Name:ZFP30
    Synonyms:KIAA0961, ZNF745
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:29555. ZFP30.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA143485675.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 519519Zinc finger protein 30 homologPRO_0000047291Add
    BLAST

    Proteomic databases

    PaxDbiQ9Y2G7.
    PRIDEiQ9Y2G7.

    PTM databases

    PhosphoSiteiQ9Y2G7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Y2G7.
    BgeeiQ9Y2G7.
    CleanExiHS_ZFP30.
    GenevestigatoriQ9Y2G7.

    Organism-specific databases

    HPAiHPA030606.

    Interactioni

    Protein-protein interaction databases

    BioGridi116509. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y2G7.
    SMRiQ9Y2G7. Positions 145-516.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini6 – 7873KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri158 – 18023C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri186 – 20823C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri214 – 23623C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri242 – 26423C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri270 – 29223C2H2-type 5; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri298 – 32023C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri326 – 34823C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri354 – 37623C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri382 – 40423C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri410 – 43223C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri438 – 46023C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri466 – 48823C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri494 – 51623C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiQ9Y2G7.
    KOiK09228.
    OMAiGLEGQES.
    PhylomeDBiQ9Y2G7.
    TreeFamiTF341817.

    Family and domain databases

    Gene3Di3.30.160.60. 13 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 13 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 12 hits.
    PS50157. ZINC_FINGER_C2H2_2. 13 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Y2G7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARDLVMFRD VAVDFSQEEW ECLNSYQRNL YRDVILENYS NLVSLAGCSI    50
    SKPDVITLLE QGKEPWMVVR DEKRRWTLDL ESRYDTKKLF QGKDIYEMNL 100
    SQWKVMERIK SCGLEEQESP HEVCFRQVTK TTSEKMPTYR KLTSLPLYQK 150
    SHNREKPYEC GECGKAFRVR QQLTFHQRIH TGEKPYECKE CGKAFRQCAH 200
    LSRHQRIHTS DKLYECKKCG KIFTCGSDLR VHQRIHIGEK PYECKECGKA 250
    FRVRGQLNLH QRIHTGEKPY ECKECGKAFR QYAHLTRHQR LNIAEKCYEC 300
    KECGQAFLCS TGLRLHHKLH TGEKPYECKE CGKAFRVRQQ LTLHQRIHTG 350
    EKPYDCKECG KTFSRGYHLT LHQRIHTGEK PYECKECQKF FRRYSELISH 400
    QGIHIGEKPY ECKECGKAFR LFSQLTQHQS IHFGEKPFKC KECEKTFRLL 450
    SQLTQHQSIH TGEKPYDCKE CGKAFRLHSS LIQHQRIHSG EKPYKCKECK 500
    KAFRQHSHLT YHQRIHNVT 519
    Length:519
    Mass (Da):61,558
    Last modified:November 1, 1999 - v1
    Checksum:iA0903F75E3B1C320
    GO

    Sequence cautioni

    The sequence BAA76805.2 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB023178 mRNA. Translation: BAA76805.2. Different initiation.
    BC041087 mRNA. Translation: AAH41087.1.
    CCDSiCCDS33005.1.
    RefSeqiNP_055713.1. NM_014898.2.
    XP_006723152.1. XM_006723089.1.
    UniGeneiHs.716719.
    Hs.722657.

    Genome annotation databases

    EnsembliENST00000351218; ENSP00000343581; ENSG00000120784.
    ENST00000392144; ENSP00000375988; ENSG00000120784.
    ENST00000514101; ENSP00000422930; ENSG00000120784.
    GeneIDi22835.
    KEGGihsa:22835.
    UCSCiuc002ogv.1. human.

    Polymorphism databases

    DMDMi6686181.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB023178 mRNA. Translation: BAA76805.2 . Different initiation.
    BC041087 mRNA. Translation: AAH41087.1 .
    CCDSi CCDS33005.1.
    RefSeqi NP_055713.1. NM_014898.2.
    XP_006723152.1. XM_006723089.1.
    UniGenei Hs.716719.
    Hs.722657.

    3D structure databases

    ProteinModelPortali Q9Y2G7.
    SMRi Q9Y2G7. Positions 145-516.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116509. 1 interaction.

    PTM databases

    PhosphoSitei Q9Y2G7.

    Polymorphism databases

    DMDMi 6686181.

    Proteomic databases

    PaxDbi Q9Y2G7.
    PRIDEi Q9Y2G7.

    Protocols and materials databases

    DNASUi 22835.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000351218 ; ENSP00000343581 ; ENSG00000120784 .
    ENST00000392144 ; ENSP00000375988 ; ENSG00000120784 .
    ENST00000514101 ; ENSP00000422930 ; ENSG00000120784 .
    GeneIDi 22835.
    KEGGi hsa:22835.
    UCSCi uc002ogv.1. human.

    Organism-specific databases

    CTDi 22835.
    GeneCardsi GC19M038123.
    HGNCi HGNC:29555. ZFP30.
    HPAi HPA030606.
    neXtProti NX_Q9Y2G7.
    PharmGKBi PA143485675.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi Q9Y2G7.
    KOi K09228.
    OMAi GLEGQES.
    PhylomeDBi Q9Y2G7.
    TreeFami TF341817.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.

    Miscellaneous databases

    GenomeRNAii 22835.
    NextBioi 43265.
    PROi Q9Y2G7.

    Gene expression databases

    ArrayExpressi Q9Y2G7.
    Bgeei Q9Y2G7.
    CleanExi HS_ZFP30.
    Genevestigatori Q9Y2G7.

    Family and domain databases

    Gene3Di 3.30.160.60. 13 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 13 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 12 hits.
    PS50157. ZINC_FINGER_C2H2_2. 13 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.

    Entry informationi

    Entry nameiZFP30_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y2G7
    Secondary accession number(s): Q58EY8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 125 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3