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Protein

Ankyrin repeat domain-containing protein 6

Gene

ANKRD6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Recruits CKI-epsilon to the beta-catenin degradation complex that consists of AXN1 or AXN2 and GSK3-beta and allows efficient phosphorylation of beta-catenin, thereby inhibiting beta-catenin/Tcf signals.By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ9Y2G4.
SIGNORiQ9Y2G4.

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 6
Alternative name(s):
Diversin
Gene namesi
Name:ANKRD6
Synonyms:KIAA0957
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:17280. ANKRD6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24807.

Polymorphism and mutation databases

BioMutaiANKRD6.
DMDMi327478595.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 727727Ankyrin repeat domain-containing protein 6PRO_0000066901Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki40 – 40Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ9Y2G4.
PeptideAtlasiQ9Y2G4.
PRIDEiQ9Y2G4.

PTM databases

iPTMnetiQ9Y2G4.
PhosphoSiteiQ9Y2G4.

Expressioni

Gene expression databases

BgeeiENSG00000135299.
CleanExiHS_ANKRD6.
ExpressionAtlasiQ9Y2G4. baseline and differential.
GenevisibleiQ9Y2G4. HS.

Organism-specific databases

HPAiCAB020693.
HPA035694.
HPA064642.

Interactioni

Subunit structurei

Interacts with AXN1, AXN2 and CSNK1E/CKI-epsilon.By similarity

Protein-protein interaction databases

BioGridi116548. 4 interactions.
DIPiDIP-39375N.
IntActiQ9Y2G4. 3 interactions.
STRINGi9606.ENSP00000345767.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2G4.
SMRiQ9Y2G4. Positions 14-265.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati9 – 3830ANK 1Add
BLAST
Repeati41 – 7030ANK 2Add
BLAST
Repeati74 – 10330ANK 3Add
BLAST
Repeati107 – 13630ANK 4Add
BLAST
Repeati140 – 16930ANK 5Add
BLAST
Repeati173 – 20230ANK 6Add
BLAST
Repeati206 – 23530ANK 7Add
BLAST
Repeati239 – 26830ANK 8Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili417 – 44630Sequence analysisAdd
BLAST
Coiled coili682 – 72746Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi382 – 3854Poly-Pro

Sequence similaritiesi

Contains 8 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00790000122981.
HOGENOMiHOG000231720.
HOVERGENiHBG050504.
InParanoidiQ9Y2G4.
OrthoDBiEOG091G02VN.
PhylomeDBiQ9Y2G4.
TreeFamiTF332587.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 8 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 6 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y2G4-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSQQDAVAAL SERLLVAAYK GQTENVVQLI NKGARVAVTK HGRTPLHLAA
60 70 80 90 100
NKGHLPVVQI LLKAGCDLDV QDDGDQTALH RATVVGNTEI IAALIHEGCA
110 120 130 140 150
LDRQDKDGNT ALHEASWHGF SQSAKLLIKA GANVLAKNKA GNTALHLACQ
160 170 180 190 200
NSHSQSTRVL LLAGSRADLK NNAGDTCLHV AARYNHLSII RLLLTAFCSV
210 220 230 240 250
HEKNQAGDTA LHVAAALNHK KVAKILLEAG ADTTIVNNAG QTPLETARYH
260 270 280 290 300
NNPEVALLLT KAPQVLRFSR GRSLRKKRER LKEERRAQSV PRDEVAQSKG
310 320 330 340 350
SVSAGDTPSS EQAVARKEEA REEFLSASPE PRAKDDRRRK SRPKVSAFSD
360 370 380 390 400
PTPPADQQPG HQKNLHAHNH PKKRNRHRCS SPPPPHEFRA YQLYTLYRGK
410 420 430 440 450
DGKVMQAPIN GCRCEPLINK LENQLEATVE EIKAELGSVQ DKMNTKLGQM
460 470 480 490 500
ENKTQHQMRV LDKLMVERLS AERTECLNRL QQHSDTEKHE GEKRQISLVD
510 520 530 540 550
ELKTWCMLKI QNLEQKLSGD SRACRAKSTP STCESSTGVD QLVVTAGPAA
560 570 580 590 600
ASDSSPPVVR PKEKALNSTA TQRLQQELSS SDCTGSRLRN VKVQTALLPM
610 620 630 640 650
NEAARSDQQA GPCVNRGTQT KKSGKSGPTR HRAQQPAASS TCGQPPPATG
660 670 680 690 700
SEQTGPHIRD TSQALELTQY FFEAVSTQME KWYERKIEEA RSQANQKAQQ
710 720
DKATLKEHIK SLEEELAKLR TRVQKEN
Length:727
Mass (Da):79,971
Last modified:April 5, 2011 - v3
Checksum:iFACD861BDEEF1905
GO
Isoform 2 (identifier: Q9Y2G4-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     265-299: Missing.

Show »
Length:692
Mass (Da):75,736
Checksum:iDB132A487C55F1FF
GO
Isoform 3 (identifier: Q9Y2G4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     534-538: Missing.

Note: No experimental confirmation available.
Show »
Length:722
Mass (Da):79,510
Checksum:i9B0D52E22A8B8B7C
GO
Isoform 4 (identifier: Q9Y2G4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     106-138: Missing.
     239-264: Missing.
     534-538: Missing.

Show »
Length:663
Mass (Da):73,235
Checksum:i9EBE1F6128BE823F
GO

Sequence cautioni

The sequence BAA76801 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti87 – 871N → I in CAB55968 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti122 – 1221Q → E.
Corresponds to variant rs16881983 [ dbSNP | Ensembl ].
VAR_039114
Natural varianti128 – 1281I → V.3 Publications
Corresponds to variant rs3748085 [ dbSNP | Ensembl ].
VAR_039115
Natural varianti233 – 2331T → M.
Corresponds to variant rs2273238 [ dbSNP | Ensembl ].
VAR_039116
Natural varianti545 – 5451T → A.
Corresponds to variant rs9362667 [ dbSNP | Ensembl ].
VAR_039117
Natural varianti550 – 5501A → T.
Corresponds to variant rs9362667 [ dbSNP | Ensembl ].
VAR_055506

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei106 – 13833Missing in isoform 4. 1 PublicationVSP_043189Add
BLAST
Alternative sequencei239 – 26426Missing in isoform 4. 1 PublicationVSP_043190Add
BLAST
Alternative sequencei265 – 29935Missing in isoform 2. 1 PublicationVSP_000270Add
BLAST
Alternative sequencei534 – 5385Missing in isoform 3 and isoform 4. 2 PublicationsVSP_031591

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023174 mRNA. Translation: BAA76801.2. Different initiation.
AK096867 mRNA. Translation: BAG53385.1.
AL096678, AL159174 Genomic DNA. Translation: CAI42280.1.
AL096678, AL159174 Genomic DNA. Translation: CAI42281.1.
AL136971 Genomic DNA. No translation available.
AL138717 Genomic DNA. No translation available.
BC042173 mRNA. Translation: AAH42173.1.
AL117504 mRNA. Translation: CAB55968.1.
CCDSiCCDS47460.1. [Q9Y2G4-3]
CCDS56441.1. [Q9Y2G4-2]
CCDS56442.1. [Q9Y2G4-1]
CCDS56443.1. [Q9Y2G4-4]
RefSeqiNP_001229738.1. NM_001242809.1. [Q9Y2G4-2]
NP_001229740.1. NM_001242811.1. [Q9Y2G4-2]
NP_001229742.1. NM_001242813.1. [Q9Y2G4-1]
NP_001229743.1. NM_001242814.1. [Q9Y2G4-4]
NP_055757.3. NM_014942.4. [Q9Y2G4-3]
XP_005248738.1. XM_005248681.2. [Q9Y2G4-2]
XP_011533902.1. XM_011535600.2. [Q9Y2G4-4]
UniGeneiHs.702213.

Genome annotation databases

EnsembliENST00000339746; ENSP00000345767; ENSG00000135299. [Q9Y2G4-2]
ENST00000369408; ENSP00000358416; ENSG00000135299. [Q9Y2G4-1]
ENST00000447838; ENSP00000396771; ENSG00000135299. [Q9Y2G4-3]
ENST00000520793; ENSP00000429782; ENSG00000135299. [Q9Y2G4-4]
ENST00000522441; ENSP00000430985; ENSG00000135299. [Q9Y2G4-2]
GeneIDi22881.
KEGGihsa:22881.
UCSCiuc003pne.5. human. [Q9Y2G4-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023174 mRNA. Translation: BAA76801.2. Different initiation.
AK096867 mRNA. Translation: BAG53385.1.
AL096678, AL159174 Genomic DNA. Translation: CAI42280.1.
AL096678, AL159174 Genomic DNA. Translation: CAI42281.1.
AL136971 Genomic DNA. No translation available.
AL138717 Genomic DNA. No translation available.
BC042173 mRNA. Translation: AAH42173.1.
AL117504 mRNA. Translation: CAB55968.1.
CCDSiCCDS47460.1. [Q9Y2G4-3]
CCDS56441.1. [Q9Y2G4-2]
CCDS56442.1. [Q9Y2G4-1]
CCDS56443.1. [Q9Y2G4-4]
RefSeqiNP_001229738.1. NM_001242809.1. [Q9Y2G4-2]
NP_001229740.1. NM_001242811.1. [Q9Y2G4-2]
NP_001229742.1. NM_001242813.1. [Q9Y2G4-1]
NP_001229743.1. NM_001242814.1. [Q9Y2G4-4]
NP_055757.3. NM_014942.4. [Q9Y2G4-3]
XP_005248738.1. XM_005248681.2. [Q9Y2G4-2]
XP_011533902.1. XM_011535600.2. [Q9Y2G4-4]
UniGeneiHs.702213.

3D structure databases

ProteinModelPortaliQ9Y2G4.
SMRiQ9Y2G4. Positions 14-265.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116548. 4 interactions.
DIPiDIP-39375N.
IntActiQ9Y2G4. 3 interactions.
STRINGi9606.ENSP00000345767.

PTM databases

iPTMnetiQ9Y2G4.
PhosphoSiteiQ9Y2G4.

Polymorphism and mutation databases

BioMutaiANKRD6.
DMDMi327478595.

Proteomic databases

PaxDbiQ9Y2G4.
PeptideAtlasiQ9Y2G4.
PRIDEiQ9Y2G4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339746; ENSP00000345767; ENSG00000135299. [Q9Y2G4-2]
ENST00000369408; ENSP00000358416; ENSG00000135299. [Q9Y2G4-1]
ENST00000447838; ENSP00000396771; ENSG00000135299. [Q9Y2G4-3]
ENST00000520793; ENSP00000429782; ENSG00000135299. [Q9Y2G4-4]
ENST00000522441; ENSP00000430985; ENSG00000135299. [Q9Y2G4-2]
GeneIDi22881.
KEGGihsa:22881.
UCSCiuc003pne.5. human. [Q9Y2G4-2]

Organism-specific databases

CTDi22881.
GeneCardsiANKRD6.
HGNCiHGNC:17280. ANKRD6.
HPAiCAB020693.
HPA035694.
HPA064642.
MIMi610583. gene.
neXtProtiNX_Q9Y2G4.
PharmGKBiPA24807.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00790000122981.
HOGENOMiHOG000231720.
HOVERGENiHBG050504.
InParanoidiQ9Y2G4.
OrthoDBiEOG091G02VN.
PhylomeDBiQ9Y2G4.
TreeFamiTF332587.

Enzyme and pathway databases

SignaLinkiQ9Y2G4.
SIGNORiQ9Y2G4.

Miscellaneous databases

ChiTaRSiANKRD6. human.
GenomeRNAii22881.
PROiQ9Y2G4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135299.
CleanExiHS_ANKRD6.
ExpressionAtlasiQ9Y2G4. baseline and differential.
GenevisibleiQ9Y2G4. HS.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 8 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANKR6_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2G4
Secondary accession number(s): B3KUC3
, Q5JUJ4, Q5JUJ5, Q8IUQ8, Q9NU24, Q9UFQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: April 5, 2011
Last modified: September 7, 2016
This is version 143 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.