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Protein

Ankyrin repeat domain-containing protein 6

Gene

ANKRD6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Recruits CKI-epsilon to the beta-catenin degradation complex that consists of AXN1 or AXN2 and GSK3-beta and allows efficient phosphorylation of beta-catenin, thereby inhibiting beta-catenin/Tcf signals.By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135299-MONOMER.
SignaLinkiQ9Y2G4.
SIGNORiQ9Y2G4.

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 6
Alternative name(s):
Diversin
Gene namesi
Name:ANKRD6
Synonyms:KIAA0957
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:17280. ANKRD6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi22881.
OpenTargetsiENSG00000135299.
PharmGKBiPA24807.

Polymorphism and mutation databases

BioMutaiANKRD6.
DMDMi327478595.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000669011 – 727Ankyrin repeat domain-containing protein 6Add BLAST727

Proteomic databases

PaxDbiQ9Y2G4.
PeptideAtlasiQ9Y2G4.
PRIDEiQ9Y2G4.

PTM databases

iPTMnetiQ9Y2G4.
PhosphoSitePlusiQ9Y2G4.

Expressioni

Gene expression databases

BgeeiENSG00000135299.
CleanExiHS_ANKRD6.
ExpressionAtlasiQ9Y2G4. baseline and differential.
GenevisibleiQ9Y2G4. HS.

Organism-specific databases

HPAiCAB020693.
HPA035694.
HPA064642.

Interactioni

Subunit structurei

Interacts with AXN1, AXN2 and CSNK1E/CKI-epsilon.By similarity

Protein-protein interaction databases

BioGridi116548. 4 interactors.
DIPiDIP-39375N.
IntActiQ9Y2G4. 3 interactors.
STRINGi9606.ENSP00000345767.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2G4.
SMRiQ9Y2G4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati9 – 38ANK 1Add BLAST30
Repeati41 – 70ANK 2Add BLAST30
Repeati74 – 103ANK 3Add BLAST30
Repeati107 – 136ANK 4Add BLAST30
Repeati140 – 169ANK 5Add BLAST30
Repeati173 – 202ANK 6Add BLAST30
Repeati206 – 235ANK 7Add BLAST30
Repeati239 – 268ANK 8Add BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili417 – 446Sequence analysisAdd BLAST30
Coiled coili682 – 727Sequence analysisAdd BLAST46

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi382 – 385Poly-Pro4

Sequence similaritiesi

Contains 8 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00860000133710.
HOGENOMiHOG000231720.
HOVERGENiHBG050504.
InParanoidiQ9Y2G4.
OrthoDBiEOG091G02VN.
PhylomeDBiQ9Y2G4.
TreeFamiTF332587.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 8 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 6 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y2G4-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSQQDAVAAL SERLLVAAYK GQTENVVQLI NKGARVAVTK HGRTPLHLAA
60 70 80 90 100
NKGHLPVVQI LLKAGCDLDV QDDGDQTALH RATVVGNTEI IAALIHEGCA
110 120 130 140 150
LDRQDKDGNT ALHEASWHGF SQSAKLLIKA GANVLAKNKA GNTALHLACQ
160 170 180 190 200
NSHSQSTRVL LLAGSRADLK NNAGDTCLHV AARYNHLSII RLLLTAFCSV
210 220 230 240 250
HEKNQAGDTA LHVAAALNHK KVAKILLEAG ADTTIVNNAG QTPLETARYH
260 270 280 290 300
NNPEVALLLT KAPQVLRFSR GRSLRKKRER LKEERRAQSV PRDEVAQSKG
310 320 330 340 350
SVSAGDTPSS EQAVARKEEA REEFLSASPE PRAKDDRRRK SRPKVSAFSD
360 370 380 390 400
PTPPADQQPG HQKNLHAHNH PKKRNRHRCS SPPPPHEFRA YQLYTLYRGK
410 420 430 440 450
DGKVMQAPIN GCRCEPLINK LENQLEATVE EIKAELGSVQ DKMNTKLGQM
460 470 480 490 500
ENKTQHQMRV LDKLMVERLS AERTECLNRL QQHSDTEKHE GEKRQISLVD
510 520 530 540 550
ELKTWCMLKI QNLEQKLSGD SRACRAKSTP STCESSTGVD QLVVTAGPAA
560 570 580 590 600
ASDSSPPVVR PKEKALNSTA TQRLQQELSS SDCTGSRLRN VKVQTALLPM
610 620 630 640 650
NEAARSDQQA GPCVNRGTQT KKSGKSGPTR HRAQQPAASS TCGQPPPATG
660 670 680 690 700
SEQTGPHIRD TSQALELTQY FFEAVSTQME KWYERKIEEA RSQANQKAQQ
710 720
DKATLKEHIK SLEEELAKLR TRVQKEN
Length:727
Mass (Da):79,971
Last modified:April 5, 2011 - v3
Checksum:iFACD861BDEEF1905
GO
Isoform 2 (identifier: Q9Y2G4-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     265-299: Missing.

Show »
Length:692
Mass (Da):75,736
Checksum:iDB132A487C55F1FF
GO
Isoform 3 (identifier: Q9Y2G4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     534-538: Missing.

Note: No experimental confirmation available.
Show »
Length:722
Mass (Da):79,510
Checksum:i9B0D52E22A8B8B7C
GO
Isoform 4 (identifier: Q9Y2G4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     106-138: Missing.
     239-264: Missing.
     534-538: Missing.

Show »
Length:663
Mass (Da):73,235
Checksum:i9EBE1F6128BE823F
GO

Sequence cautioni

The sequence BAA76801 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti87N → I in CAB55968 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_039114122Q → E.Corresponds to variant rs16881983dbSNPEnsembl.1
Natural variantiVAR_039115128I → V.3 PublicationsCorresponds to variant rs3748085dbSNPEnsembl.1
Natural variantiVAR_039116233T → M.Corresponds to variant rs2273238dbSNPEnsembl.1
Natural variantiVAR_039117545T → A.Corresponds to variant rs9362667dbSNPEnsembl.1
Natural variantiVAR_055506550A → T.Corresponds to variant rs9362667dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_043189106 – 138Missing in isoform 4. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_043190239 – 264Missing in isoform 4. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_000270265 – 299Missing in isoform 2. 1 PublicationAdd BLAST35
Alternative sequenceiVSP_031591534 – 538Missing in isoform 3 and isoform 4. 2 Publications5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023174 mRNA. Translation: BAA76801.2. Different initiation.
AK096867 mRNA. Translation: BAG53385.1.
AL096678, AL159174 Genomic DNA. Translation: CAI42280.1.
AL096678, AL159174 Genomic DNA. Translation: CAI42281.1.
AL136971 Genomic DNA. No translation available.
AL138717 Genomic DNA. No translation available.
BC042173 mRNA. Translation: AAH42173.1.
AL117504 mRNA. Translation: CAB55968.1.
CCDSiCCDS47460.1. [Q9Y2G4-3]
CCDS56441.1. [Q9Y2G4-2]
CCDS56442.1. [Q9Y2G4-1]
CCDS56443.1. [Q9Y2G4-4]
RefSeqiNP_001229738.1. NM_001242809.1. [Q9Y2G4-2]
NP_001229740.1. NM_001242811.1. [Q9Y2G4-2]
NP_001229742.1. NM_001242813.1. [Q9Y2G4-1]
NP_001229743.1. NM_001242814.1. [Q9Y2G4-4]
NP_055757.3. NM_014942.4. [Q9Y2G4-3]
XP_005248738.1. XM_005248681.2. [Q9Y2G4-2]
XP_011533902.1. XM_011535600.2. [Q9Y2G4-4]
UniGeneiHs.702213.

Genome annotation databases

EnsembliENST00000339746; ENSP00000345767; ENSG00000135299. [Q9Y2G4-2]
ENST00000369408; ENSP00000358416; ENSG00000135299. [Q9Y2G4-1]
ENST00000447838; ENSP00000396771; ENSG00000135299. [Q9Y2G4-3]
ENST00000520793; ENSP00000429782; ENSG00000135299. [Q9Y2G4-4]
ENST00000522441; ENSP00000430985; ENSG00000135299. [Q9Y2G4-2]
GeneIDi22881.
KEGGihsa:22881.
UCSCiuc003pne.5. human. [Q9Y2G4-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023174 mRNA. Translation: BAA76801.2. Different initiation.
AK096867 mRNA. Translation: BAG53385.1.
AL096678, AL159174 Genomic DNA. Translation: CAI42280.1.
AL096678, AL159174 Genomic DNA. Translation: CAI42281.1.
AL136971 Genomic DNA. No translation available.
AL138717 Genomic DNA. No translation available.
BC042173 mRNA. Translation: AAH42173.1.
AL117504 mRNA. Translation: CAB55968.1.
CCDSiCCDS47460.1. [Q9Y2G4-3]
CCDS56441.1. [Q9Y2G4-2]
CCDS56442.1. [Q9Y2G4-1]
CCDS56443.1. [Q9Y2G4-4]
RefSeqiNP_001229738.1. NM_001242809.1. [Q9Y2G4-2]
NP_001229740.1. NM_001242811.1. [Q9Y2G4-2]
NP_001229742.1. NM_001242813.1. [Q9Y2G4-1]
NP_001229743.1. NM_001242814.1. [Q9Y2G4-4]
NP_055757.3. NM_014942.4. [Q9Y2G4-3]
XP_005248738.1. XM_005248681.2. [Q9Y2G4-2]
XP_011533902.1. XM_011535600.2. [Q9Y2G4-4]
UniGeneiHs.702213.

3D structure databases

ProteinModelPortaliQ9Y2G4.
SMRiQ9Y2G4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116548. 4 interactors.
DIPiDIP-39375N.
IntActiQ9Y2G4. 3 interactors.
STRINGi9606.ENSP00000345767.

PTM databases

iPTMnetiQ9Y2G4.
PhosphoSitePlusiQ9Y2G4.

Polymorphism and mutation databases

BioMutaiANKRD6.
DMDMi327478595.

Proteomic databases

PaxDbiQ9Y2G4.
PeptideAtlasiQ9Y2G4.
PRIDEiQ9Y2G4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339746; ENSP00000345767; ENSG00000135299. [Q9Y2G4-2]
ENST00000369408; ENSP00000358416; ENSG00000135299. [Q9Y2G4-1]
ENST00000447838; ENSP00000396771; ENSG00000135299. [Q9Y2G4-3]
ENST00000520793; ENSP00000429782; ENSG00000135299. [Q9Y2G4-4]
ENST00000522441; ENSP00000430985; ENSG00000135299. [Q9Y2G4-2]
GeneIDi22881.
KEGGihsa:22881.
UCSCiuc003pne.5. human. [Q9Y2G4-2]

Organism-specific databases

CTDi22881.
DisGeNETi22881.
GeneCardsiANKRD6.
HGNCiHGNC:17280. ANKRD6.
HPAiCAB020693.
HPA035694.
HPA064642.
MIMi610583. gene.
neXtProtiNX_Q9Y2G4.
OpenTargetsiENSG00000135299.
PharmGKBiPA24807.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00860000133710.
HOGENOMiHOG000231720.
HOVERGENiHBG050504.
InParanoidiQ9Y2G4.
OrthoDBiEOG091G02VN.
PhylomeDBiQ9Y2G4.
TreeFamiTF332587.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135299-MONOMER.
SignaLinkiQ9Y2G4.
SIGNORiQ9Y2G4.

Miscellaneous databases

ChiTaRSiANKRD6. human.
GenomeRNAii22881.
PROiQ9Y2G4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135299.
CleanExiHS_ANKRD6.
ExpressionAtlasiQ9Y2G4. baseline and differential.
GenevisibleiQ9Y2G4. HS.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 8 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANKR6_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2G4
Secondary accession number(s): B3KUC3
, Q5JUJ4, Q5JUJ5, Q8IUQ8, Q9NU24, Q9UFQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: April 5, 2011
Last modified: November 30, 2016
This is version 146 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.