Reviewed, UniProtKB/Swiss-Prot Q9Y2G4 (ANKR6_HUMAN)

Names and origin

Protein names

Recommended name:
    Ankyrin repeat domain-containing protein 6
Alternative name(s):
    Diversin

Gene names

Name:	ANKRD6
Synonyms:	KIAA0957

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	727 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Recruits CKI-epsilon to the beta-catenin degradation complex that consists of AXN1 or AXN2 and GSK3-beta and allows efficient phosphorylation of beta-catenin, thereby inhibiting beta-catenin/Tcf signals By similarity.
Subunit structure	Interacts with AXN1, AXN2 and CSNK1E/CKI-epsilon By similarity.
Sequence similarities	Contains 8 ANK repeats.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	ANK repeat Coiled coil Repeat
PTM	Isopeptide bond Ubl conjugation
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
csrp1	Q6NZV4	1	EBI-1054868,EBI-1535300	From a different organism.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9Y2G4-2)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Y2G4-1)

The sequence of this isoform differs from the canonical sequence as follows:
     265-299: Missing.

Isoform 3 (identifier: Q9Y2G4-3)

The sequence of this isoform differs from the canonical sequence as follows:
     534-538: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 727	727	Ankyrin repeat domain-containing protein 6		PRO_0000066901
Regions
	Repeat	9 – 38	30	ANK 1
	Repeat	41 – 70	30	ANK 2
	Repeat	74 – 103	30	ANK 3
	Repeat	107 – 136	30	ANK 4
	Repeat	140 – 169	30	ANK 5
	Repeat	173 – 202	30	ANK 6
	Repeat	206 – 235	30	ANK 7
	Repeat	239 – 268	30	ANK 8
	Coiled coil	417 – 446	30	Potential
	Coiled coil	682 – 727	46	Potential
	Compositional bias	382 – 385	4	Poly-Pro
Amino acid modifications
	Cross-link	40		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.5
Natural variations
	Alternative sequence	265 – 299	35	Missing in isoform 2.		VSP_000270
	Alternative sequence	534 – 538	5	Missing in isoform 3.		VSP_031591
	Natural variant	122	1	Q → E: dbSNP rs16881983.		VAR_039114
	Natural variant	128	1	V → I: dbSNP rs3748085. Ref.2		VAR_039115
	Natural variant	233	1	T → M: dbSNP rs2273238.		VAR_039116
	Natural variant	545	1	T → A: dbSNP rs9362667.		VAR_039117
	Natural variant	550	1	A → T: dbSNP rs9362667.		VAR_055506
Experimental info
	Sequence conflict	87	1	N → I in CAB55968. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 26, 2008. Version 2. Checksum: 022914A2F578F8CC	FASTA	727	79,957
	10 20 30 40 50 60 MSQQDAVAAL SERLLVAAYK GQTENVVQLI NKGARVAVTK HGRTPLHLAA NKGHLPVVQI 70 80 90 100 110 120 LLKAGCDLDV QDDGDQTALH RATVVGNTEI IAALIHEGCA LDRQDKDGNT ALHEASWHGF 130 140 150 160 170 180 SQSAKLLVKA GANVLAKNKA GNTALHLACQ NSHSQSTRVL LLAGSRADLK NNAGDTCLHV 190 200 210 220 230 240 AARYNHLSII RLLLTAFCSV HEKNQAGDTA LHVAAALNHK KVAKILLEAG ADTTIVNNAG 250 260 270 280 290 300 QTPLETARYH NNPEVALLLT KAPQVLRFSR GRSLRKKRER LKEERRAQSV PRDEVAQSKG 310 320 330 340 350 360 SVSAGDTPSS EQAVARKEEA REEFLSASPE PRAKDDRRRK SRPKVSAFSD PTPPADQQPG 370 380 390 400 410 420 HQKNLHAHNH PKKRNRHRCS SPPPPHEFRA YQLYTLYRGK DGKVMQAPIN GCRCEPLINK 430 440 450 460 470 480 LENQLEATVE EIKAELGSVQ DKMNTKLGQM ENKTQHQMRV LDKLMVERLS AERTECLNRL 490 500 510 520 530 540 QQHSDTEKHE GEKRQISLVD ELKTWCMLKI QNLEQKLSGD SRACRAKSTP STCESSTGVD 550 560 570 580 590 600 QLVVTAGPAA ASDSSPPVVR PKEKALNSTA TQRLQQELSS SDCTGSRLRN VKVQTALLPM 610 620 630 640 650 660 NEAARSDQQA GPCVNRGTQT KKSGKSGPTR HRAQQPAASS TCGQPPPATG SEQTGPHIRD 670 680 690 700 710 720 TSQALELTQY FFEAVSTQME KWYERKIEEA RSQANQKAQQ DKATLKEHIK SLEEELAKLR TRVQKEN
	Isoform 2. Checksum: D32115487A80839F	FASTA	692	75,722
	10 20 30 40 50 60 MSQQDAVAAL SERLLVAAYK GQTENVVQLI NKGARVAVTK HGRTPLHLAA NKGHLPVVQI 70 80 90 100 110 120 LLKAGCDLDV QDDGDQTALH RATVVGNTEI IAALIHEGCA LDRQDKDGNT ALHEASWHGF 130 140 150 160 170 180 SQSAKLLVKA GANVLAKNKA GNTALHLACQ NSHSQSTRVL LLAGSRADLK NNAGDTCLHV 190 200 210 220 230 240 AARYNHLSII RLLLTAFCSV HEKNQAGDTA LHVAAALNHK KVAKILLEAG ADTTIVNNAG 250 260 270 280 290 300 QTPLETARYH NNPEVALLLT KAPQGSVSAG DTPSSEQAVA RKEEAREEFL SASPEPRAKD 310 320 330 340 350 360 DRRRKSRPKV SAFSDPTPPA DQQPGHQKNL HAHNHPKKRN RHRCSSPPPP HEFRAYQLYT 370 380 390 400 410 420 LYRGKDGKVM QAPINGCRCE PLINKLENQL EATVEEIKAE LGSVQDKMNT KLGQMENKTQ 430 440 450 460 470 480 HQMRVLDKLM VERLSAERTE CLNRLQQHSD TEKHEGEKRQ ISLVDELKTW CMLKIQNLEQ 490 500 510 520 530 540 KLSGDSRACR AKSTPSTCES STGVDQLVVT AGPAAASDSS PPVVRPKEKA LNSTATQRLQ 550 560 570 580 590 600 QELSSSDCTG SRLRNVKVQT ALLPMNEAAR SDQQAGPCVN RGTQTKKSGK SGPTRHRAQQ 610 620 630 640 650 660 PAASSTCGQP PPATGSEQTG PHIRDTSQAL ELTQYFFEAV STQMEKWYER KIEEARSQAN 670 680 690 QKAQQDKATL KEHIKSLEEE LAKLRTRVQK EN
	Isoform 3. Checksum: 2CEC9B5A644FD1E2	FASTA	722	79,496
	10 20 30 40 50 60 MSQQDAVAAL SERLLVAAYK GQTENVVQLI NKGARVAVTK HGRTPLHLAA NKGHLPVVQI 70 80 90 100 110 120 LLKAGCDLDV QDDGDQTALH RATVVGNTEI IAALIHEGCA LDRQDKDGNT ALHEASWHGF 130 140 150 160 170 180 SQSAKLLVKA GANVLAKNKA GNTALHLACQ NSHSQSTRVL LLAGSRADLK NNAGDTCLHV 190 200 210 220 230 240 AARYNHLSII RLLLTAFCSV HEKNQAGDTA LHVAAALNHK KVAKILLEAG ADTTIVNNAG 250 260 270 280 290 300 QTPLETARYH NNPEVALLLT KAPQVLRFSR GRSLRKKRER LKEERRAQSV PRDEVAQSKG 310 320 330 340 350 360 SVSAGDTPSS EQAVARKEEA REEFLSASPE PRAKDDRRRK SRPKVSAFSD PTPPADQQPG 370 380 390 400 410 420 HQKNLHAHNH PKKRNRHRCS SPPPPHEFRA YQLYTLYRGK DGKVMQAPIN GCRCEPLINK 430 440 450 460 470 480 LENQLEATVE EIKAELGSVQ DKMNTKLGQM ENKTQHQMRV LDKLMVERLS AERTECLNRL 490 500 510 520 530 540 QQHSDTEKHE GEKRQISLVD ELKTWCMLKI QNLEQKLSGD SRACRAKSTP STCVDQLVVT 550 560 570 580 590 600 AGPAAASDSS PPVVRPKEKA LNSTATQRLQ QELSSSDCTG SRLRNVKVQT ALLPMNEAAR 610 620 630 640 650 660 SDQQAGPCVN RGTQTKKSGK SGPTRHRAQQ PAASSTCGQP PPATGSEQTG PHIRDTSQAL 670 680 690 700 710 720 ELTQYFFEAV STQMEKWYER KIEEARSQAN QKAQQDKATL KEHIKSLEEE LAKLRTRVQK EN

References

[1]	"Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 6:63-70(1999) [PubMed: 10231032] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[2]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ILE-128.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Brain.
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 87-727 (ISOFORM 1). Tissue: Testis.
[5]	"Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry." Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D. Proteomics 7:868-874(2007) [PubMed: 17370265] [Abstract] Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-40, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB023174 mRNA. Translation: BAA76801.2. Different initiation. AL096678, AL159174 Genomic DNA. Translation: CAI42280.1. AL096678, AL159174 Genomic DNA. Translation: CAI42281.1. BC042173 mRNA. Translation: AAH42173.1. AL117504 mRNA. Translation: CAB55968.1.
IPI	IPI00032135. IPI00218274. IPI00885007.
RefSeq	NP_055757.2.
UniGene	Hs.702213
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y2G4. 3 interactions.
STRING	Q9Y2G4.
Proteomic databases
PRIDE	Q9Y2G4.
Genome annotation databases
Ensembl	ENST00000339746; ENSP00000345767; ENSG00000135299; Homo sapiens. [Genome view]
GeneID	22881.
KEGG	hsa:22881.
UCSC	uc003pne.2. human. uc003pnf.2. human. uc003pni.2. human.
Organism-specific databases
CTD	22881.
GeneCards	GC06P090199.
H-InvDB	HIX0006066. HIX0020034.
HGNC	HGNC:17280. ANKRD6.
HPA	CAB020693.
MIM	610583. gene.
PharmGKB	PA24807.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q9Y2G4.
Gene expression databases
ArrayExpress	Q9Y2G4.
Bgee	Q9Y2G4.
CleanEx	HS_ANKRD6.
Genevestigator	Q9Y2G4.
Family and domain databases
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 1 hit.
Pfam	PF00023. Ank. 8 hits. [Graphical view]
SMART	SM00248. ANK. 8 hits. [Graphical view]
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 6 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	43457.
SOURCE	Search...

Entry information

Entry name

ANKR6_HUMAN

Accession

Primary (citable) accession number: Q9Y2G4
Secondary accession number(s): Q5JUJ4 , Q5JUJ5, Q8IUQ8, Q9NU24, Q9UFQ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	February 26, 2008
Last modified:	November 24, 2009
This is version 79 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.