Q9Y2G3 (AT11B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable phospholipid-transporting ATPase IF
EC=3.6.3.1

Alternative name(s):
ATPase IR
ATPase class VI type 11B

Gene names

Name:	ATP11B
Synonyms:	ATPIF, ATPIR, KIAA0956

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1177 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	ATP + H2O + phospholipid(In) = ADP + phosphate + phospholipid(Out).
Subcellular location	Membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. [View classification]
Sequence caution	The sequence AAH10630.1 differs from that shown. Reason: Frameshift at position 884. The sequence AAH42180.1 differs from that shown. Reason: Intron retention.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Hydrolase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	aminophospholipid transport Traceable author statement Ref.1. Source: UniProtKB cation transport Inferred from electronic annotation. Source: InterPro phospholipid translocation Non-traceable author statement. Source: UniProtKB
Cellular component	endoplasmic reticulum Inferred from direct assay. Source: UniProtKB integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW nuclear inner membrane Non-traceable author statement Ref.4. Source: UniProtKB plasma membrane Traceable author statement. Source: Reactome recycling endosome Inferred from direct assay. Source: UniProtKB
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism Inferred from electronic annotation. Source: InterPro magnesium ion binding Inferred from electronic annotation. Source: InterPro phospholipid-translocating ATPase activity Traceable author statement Ref.1. Source: UniProtKB protein binding Inferred from physical interaction. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1177	1177	Probable phospholipid-transporting ATPase IF		PRO_0000046371
Regions
	Topological domain	1 – 55	55	Cytoplasmic Potential
	Transmembrane	56 – 77	22	Helical; Potential
	Topological domain	78 – 82	5	Extracellular Potential
	Transmembrane	83 – 104	22	Helical; Potential
	Topological domain	105 – 289	185	Cytoplasmic Potential
	Transmembrane	290 – 311	22	Helical; Potential
	Topological domain	312 – 341	30	Extracellular Potential
	Transmembrane	342 – 359	18	Helical; Potential
	Topological domain	360 – 876	517	Cytoplasmic Potential
	Transmembrane	877 – 898	22	Helical; Potential
	Topological domain	899 – 910	12	Extracellular Potential
	Transmembrane	911 – 930	20	Helical; Potential
	Topological domain	931 – 960	30	Cytoplasmic Potential
	Transmembrane	961 – 982	22	Helical; Potential
	Topological domain	983 – 997	15	Extracellular Potential
	Transmembrane	998 – 1020	23	Helical; Potential
	Topological domain	1021 – 1025	5	Cytoplasmic Potential
	Transmembrane	1026 – 1047	22	Helical; Potential
	Topological domain	1048 – 1065	18	Extracellular Potential
	Transmembrane	1066 – 1090	25	Helical; Potential
	Topological domain	1091 – 1177	87	Cytoplasmic Potential
Sites
	Active site	407	1	4-aspartylphosphate intermediate By similarity
	Metal binding	821	1	Magnesium By similarity
	Metal binding	825	1	Magnesium By similarity
Amino acid modifications
	Modified residue	1154	1	Phosphoserine Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Q9Y2G3 [UniParc]. Last modified April 30, 2003. Version 2. Checksum: 665110145457B220	FASTA	1,177	134,190
	10 20 30 40 50 60 MWRWIRQQLG FDPPHQSDTR TIYVANRFPQ NGLYTPQKFI DNRIISSKYT VWNFVPKNLF 70 80 90 100 110 120 EQFRRVANFY FLIIFLVQLM IDTPTSPVTS GLPLFFVITV TAIKQGYEDW LRHNSDNEVN 130 140 150 160 170 180 GAPVYVVRSG GLVKTRSKNI RVGDIVRIAK DEIFPADLVL LSSDRLDGSC HVTTASLDGE 190 200 210 220 230 240 TNLKTHVAVP ETALLQTVAN LDTLVAVIEC QQPEADLYRF MGRMIITQQM EEIVRPLGPE 250 260 270 280 290 300 SLLLRGARLK NTKEIFGVAV YTGMETKMAL NYKSKSQKRS AVEKSMNTFL IIYLVILISE 310 320 330 340 350 360 AVISTILKYT WQAEEKWDEP WYNQKTEHQR NSSKILRFIS DFLAFLVLYN FIIPISLYVT 370 380 390 400 410 420 VEMQKFLGSF FIGWDLDLYH EESDQKAQVN TSDLNEELGQ VEYVFTDKTG TLTENEMQFR 430 440 450 460 470 480 ECSINGMKYQ EINGRLVPEG PTPDSSEGNL SYLSSLSHLN NLSHLTTSSS FRTSPENETE 490 500 510 520 530 540 LIKEHDLFFK AVSLCHTVQI SNVQTDCTGD GPWQSNLAPS QLEYYASSPD EKALVEAAAR 550 560 570 580 590 600 IGIVFIGNSE ETMEVKTLGK LERYKLLHIL EFDSDRRRMS VIVQAPSGEK LLFAKGAESS 610 620 630 640 650 660 ILPKCIGGEI EKTRIHVDEF ALKGLRTLCI AYRKFTSKEY EEIDKRIFEA RTALQQREEK 670 680 690 700 710 720 LAAVFQFIEK DLILLGATAV EDRLQDKVRE TIEALRMAGI KVWVLTGDKH ETAVSVSLSC 730 740 750 760 770 780 GHFHRTMNIL ELINQKSDSE CAEQLRQLAR RITEDHVIQH GLVVDGTSLS LALREHEKLF 790 800 810 820 830 840 MEVCRNCSAV LCCRMAPLQK AKVIRLIKIS PEKPITLAVG DGANDVSMIQ EAHVGIGIMG 850 860 870 880 890 900 KEGRQAARNS DYAIARFKFL SKLLFVHGHF YYIRIATLVQ YFFYKNVCFI TPQFLYQFYC 910 920 930 940 950 960 LFSQQTLYDS VYLTLYNICF TSLPILIYSL LEQHVDPHVL QNKPTLYRDI SKNRLLSIKT 970 980 990 1000 1010 1020 FLYWTILGFS HAFIFFFGSY LLIGKDTSLL GNGQMFGNWT FGTLVFTVMV ITVTVKMALE 1030 1040 1050 1060 1070 1080 THFWTWINHL VTWGSIIFYF VFSLFYGGIL WPFLGSQNMY FVFIQLLSSG SAWFAIILMV 1090 1100 1110 1120 1130 1140 VTCLFLDIIK KVFDRHLHPT STEKAQLTET NAGIKCLDSM CCFPEGEAAC ASVGRMLERV 1150 1160 1170 IGRCSPTHIS RSWSASDPFY TNDRSILTLS TMDSSTC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Differential expression of putative transbilayer amphipath transporters." Halleck M.S., Lawler J.F. Jr., Blackshaw S., Gao L., Nagarajan P., Hacker C., Pyle S., Newman J.T., Nakanishi Y., Ando H., Weinstock D., Williamson P.L., Schlegel R.A. Physiol. Genomics 1:139-150(1999) [PubMed: 11015572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-248. Tissue: Colon.
[2]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed: 16641997] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-195 AND 540-1177. Tissue: Colon and Mammary gland.
[4]	"Reanalysis of ATP11B, a Type IV P-type ATPase." Halleck M.S., Schlegel R.A., Williamson P.L. J. Biol. Chem. 277:9736-9740(2002) [PubMed: 11790799] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 111-450.
[5]	"Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 6:63-70(1999) [PubMed: 10231032] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 440-1111. Tissue: Brain.
[6]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 688-1111. Tissue: Testis.
[7]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1154, MASS SPECTROMETRY. Tissue: Leukemic T-cell.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF156548 mRNA. Translation: AAF09446.1. AC069431 Genomic DNA. No translation available. BC042180 mRNA. Translation: AAH42180.1. Sequence problems. BC010630 mRNA. Translation: AAH10630.1. Frameshift. AB023173 mRNA. Translation: BAA76800.1. AL133061 mRNA. Translation: CAB61385.1.
IPI	IPI00240793.
PIR	T42662.
RefSeq	NP_055431.1. NM_014616.1.
UniGene	Hs.478429.
3D structure databases
ProteinModelPortal	Q9Y2G3.
SMR	Q9Y2G3. Positions 527-682, 792-855.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9Y2G3.
PTM databases
PhosphoSite	Q9Y2G3.
Polymorphism databases
DMDM	30316395.
Proteomic databases
PRIDE	Q9Y2G3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000323116; ENSP00000321195; ENSG00000058063.
GeneID	23200.
KEGG	hsa:23200.
UCSC	uc003flb.1. human.
Organism-specific databases
CTD	23200.
GeneCards	GC03P182511.
HGNC	HGNC:13553. ATP11B.
HPA	HPA036237. HPA036238.
MIM	605869. gene.
neXtProt	NX_Q9Y2G3.
PharmGKB	PA25102.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG16101.
GeneTree	ENSGT00570000079103.
HOGENOM	HBG745019.
HOVERGEN	HBG050601.
InParanoid	Q9Y2G3.
OMA	SNVQTDG.
OrthoDB	EOG47D9F8.
PhylomeDB	Q9Y2G3.
Enzyme and pathway databases
Reactome	REACT_15518. Transmembrane transport of small molecules.
Gene expression databases
ArrayExpress	Q9Y2G3.
Bgee	Q9Y2G3.
CleanEx	HS_ATP11B.
Genevestigator	Q9Y2G3.
GermOnline	ENSG00000058063. Homo sapiens.
Family and domain databases
InterPro	IPR023306. ATPase_cation_domN. IPR008250. ATPase_P-typ_ATPase-assoc-dom. IPR023300. ATPase_P-typ_cyto_domA. IPR023299. ATPase_P-typ_cyto_domN. IPR001757. ATPase_P-typ_ion-transptr. IPR018303. ATPase_P-typ_P_site. IPR006539. ATPase_P-typ_Plipid-transl. IPR023214. HAD-like_dom. [Graphical view]
Gene3D	G3DSA:2.70.150.10. ATPase_P-typ_cyto_domA. 2 hits. G3DSA:3.40.1110.10. ATPase_P-typ_cyto_domN. 2 hits. G3DSA:3.40.50.1000. HAD-like_dom. 2 hits.
KO	K01530.
Pfam	PF00122. E1-E2_ATPase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE.
SUPFAM	SSF81660. ATPase_cation_domN. 1 hit. SSF56784. HAD-like_dom. 1 hit.
TIGRFAMs	TIGR01652. ATPase-Plipid. 1 hit. TIGR01494. ATPase_P-type. 3 hits.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	44715.
SOURCE	Search...

Entry information

Entry name

AT11B_HUMAN

Accession

Primary (citable) accession number: Q9Y2G3
Secondary accession number(s): Q96FN1, Q9UKK7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	April 30, 2003
Last modified:	January 25, 2012
This is version 102 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.