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Protein

Probable phospholipid-transporting ATPase IF

Gene

ATP11B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). Involved in regulation of sensitivity to cisplatin; may contribute to secretory vesicle transport of cisplatin from Golgi to plasma membrane.Curated1 Publication

Catalytic activityi

ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei4074-aspartylphosphate intermediateBy similarity1
Metal bindingi821MagnesiumBy similarity1
Metal bindingi825MagnesiumBy similarity1

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ion transmembrane transporter activity Source: UniProtKB
  • magnesium ion binding Source: InterPro
  • phospholipid-translocating ATPase activity Source: UniProtKB

GO - Biological processi

  • aminophospholipid transport Source: UniProtKB
  • ion transmembrane transport Source: Reactome
  • ion transport Source: UniProtKB
  • phospholipid translocation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS00716-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.
R-HSA-936837. Ion transport by P-type ATPases.

Protein family/group databases

TCDBi3.A.3.8.12. the p-type atpase (p-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phospholipid-transporting ATPase IF (EC:3.6.3.1)
Alternative name(s):
ATPase IR
ATPase class VI type 11B
P4-ATPase flippase complex alpha subunit ATP11B
Gene namesi
Name:ATP11B
Synonyms:ATPIF, ATPIR, KIAA0956
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:13553. ATP11B.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 55CytoplasmicSequence analysisAdd BLAST55
Transmembranei56 – 77HelicalSequence analysisAdd BLAST22
Topological domaini78 – 82ExtracellularSequence analysis5
Transmembranei83 – 104HelicalSequence analysisAdd BLAST22
Topological domaini105 – 289CytoplasmicSequence analysisAdd BLAST185
Transmembranei290 – 311HelicalSequence analysisAdd BLAST22
Topological domaini312 – 341ExtracellularSequence analysisAdd BLAST30
Transmembranei342 – 359HelicalSequence analysisAdd BLAST18
Topological domaini360 – 876CytoplasmicSequence analysisAdd BLAST517
Transmembranei877 – 898HelicalSequence analysisAdd BLAST22
Topological domaini899 – 910ExtracellularSequence analysisAdd BLAST12
Transmembranei911 – 930HelicalSequence analysisAdd BLAST20
Topological domaini931 – 960CytoplasmicSequence analysisAdd BLAST30
Transmembranei961 – 982HelicalSequence analysisAdd BLAST22
Topological domaini983 – 997ExtracellularSequence analysisAdd BLAST15
Transmembranei998 – 1020HelicalSequence analysisAdd BLAST23
Topological domaini1021 – 1025CytoplasmicSequence analysis5
Transmembranei1026 – 1047HelicalSequence analysisAdd BLAST22
Topological domaini1048 – 1065ExtracellularSequence analysisAdd BLAST18
Transmembranei1066 – 1090HelicalSequence analysisAdd BLAST25
Topological domaini1091 – 1177CytoplasmicSequence analysisAdd BLAST87

GO - Cellular componenti

  • early endosome Source: UniProtKB-SubCell
  • endoplasmic reticulum Source: UniProtKB
  • Golgi apparatus Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB
  • nuclear inner membrane Source: UniProtKB
  • plasma membrane Source: GO_Central
  • recycling endosome Source: UniProtKB
  • recycling endosome membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi23200.
OpenTargetsiENSG00000058063.
PharmGKBiPA25102.

Polymorphism and mutation databases

BioMutaiATP11B.
DMDMi30316395.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000463711 – 1177Probable phospholipid-transporting ATPase IFAdd BLAST1177

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1154PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y2G3.
MaxQBiQ9Y2G3.
PaxDbiQ9Y2G3.
PeptideAtlasiQ9Y2G3.
PRIDEiQ9Y2G3.

PTM databases

iPTMnetiQ9Y2G3.
PhosphoSitePlusiQ9Y2G3.
SwissPalmiQ9Y2G3.

Expressioni

Gene expression databases

BgeeiENSG00000058063.
CleanExiHS_ATP11B.
ExpressionAtlasiQ9Y2G3. baseline and differential.
GenevisibleiQ9Y2G3. HS.

Organism-specific databases

HPAiHPA036237.
HPA036238.

Interactioni

Subunit structurei

Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit and an accessory beta subunit (Probable). Interacts with beta subunit TMEM30A.Curated1 Publication

Protein-protein interaction databases

BioGridi116809. 2 interactors.
STRINGi9606.ENSP00000321195.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2G3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0206. Eukaryota.
COG0474. LUCA.
GeneTreeiENSGT00860000133712.
HOGENOMiHOG000202528.
HOVERGENiHBG050601.
InParanoidiQ9Y2G3.
KOiK01530.
OMAiTNTEKAQ.
OrthoDBiEOG091G03B1.
PhylomeDBiQ9Y2G3.
TreeFamiTF326897.

Family and domain databases

Gene3Di2.70.150.10. 2 hits.
3.40.1110.10. 2 hits.
3.40.50.1000. 2 hits.
InterProiIPR030362. ATP11B.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006539. P-type_ATPase_IV.
IPR032631. P-type_ATPase_N.
IPR001757. P_typ_ATPase.
IPR032630. P_typ_ATPase_c.
[Graphical view]
PANTHERiPTHR24092. PTHR24092. 1 hit.
PTHR24092:SF57. PTHR24092:SF57. 1 hit.
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF16212. PhoLip_ATPase_C. 1 hit.
PF16209. PhoLip_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 2 hits.
TIGRFAMsiTIGR01652. ATPase-Plipid. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y2G3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWRWIRQQLG FDPPHQSDTR TIYVANRFPQ NGLYTPQKFI DNRIISSKYT
60 70 80 90 100
VWNFVPKNLF EQFRRVANFY FLIIFLVQLM IDTPTSPVTS GLPLFFVITV
110 120 130 140 150
TAIKQGYEDW LRHNSDNEVN GAPVYVVRSG GLVKTRSKNI RVGDIVRIAK
160 170 180 190 200
DEIFPADLVL LSSDRLDGSC HVTTASLDGE TNLKTHVAVP ETALLQTVAN
210 220 230 240 250
LDTLVAVIEC QQPEADLYRF MGRMIITQQM EEIVRPLGPE SLLLRGARLK
260 270 280 290 300
NTKEIFGVAV YTGMETKMAL NYKSKSQKRS AVEKSMNTFL IIYLVILISE
310 320 330 340 350
AVISTILKYT WQAEEKWDEP WYNQKTEHQR NSSKILRFIS DFLAFLVLYN
360 370 380 390 400
FIIPISLYVT VEMQKFLGSF FIGWDLDLYH EESDQKAQVN TSDLNEELGQ
410 420 430 440 450
VEYVFTDKTG TLTENEMQFR ECSINGMKYQ EINGRLVPEG PTPDSSEGNL
460 470 480 490 500
SYLSSLSHLN NLSHLTTSSS FRTSPENETE LIKEHDLFFK AVSLCHTVQI
510 520 530 540 550
SNVQTDCTGD GPWQSNLAPS QLEYYASSPD EKALVEAAAR IGIVFIGNSE
560 570 580 590 600
ETMEVKTLGK LERYKLLHIL EFDSDRRRMS VIVQAPSGEK LLFAKGAESS
610 620 630 640 650
ILPKCIGGEI EKTRIHVDEF ALKGLRTLCI AYRKFTSKEY EEIDKRIFEA
660 670 680 690 700
RTALQQREEK LAAVFQFIEK DLILLGATAV EDRLQDKVRE TIEALRMAGI
710 720 730 740 750
KVWVLTGDKH ETAVSVSLSC GHFHRTMNIL ELINQKSDSE CAEQLRQLAR
760 770 780 790 800
RITEDHVIQH GLVVDGTSLS LALREHEKLF MEVCRNCSAV LCCRMAPLQK
810 820 830 840 850
AKVIRLIKIS PEKPITLAVG DGANDVSMIQ EAHVGIGIMG KEGRQAARNS
860 870 880 890 900
DYAIARFKFL SKLLFVHGHF YYIRIATLVQ YFFYKNVCFI TPQFLYQFYC
910 920 930 940 950
LFSQQTLYDS VYLTLYNICF TSLPILIYSL LEQHVDPHVL QNKPTLYRDI
960 970 980 990 1000
SKNRLLSIKT FLYWTILGFS HAFIFFFGSY LLIGKDTSLL GNGQMFGNWT
1010 1020 1030 1040 1050
FGTLVFTVMV ITVTVKMALE THFWTWINHL VTWGSIIFYF VFSLFYGGIL
1060 1070 1080 1090 1100
WPFLGSQNMY FVFIQLLSSG SAWFAIILMV VTCLFLDIIK KVFDRHLHPT
1110 1120 1130 1140 1150
STEKAQLTET NAGIKCLDSM CCFPEGEAAC ASVGRMLERV IGRCSPTHIS
1160 1170
RSWSASDPFY TNDRSILTLS TMDSSTC
Length:1,177
Mass (Da):134,190
Last modified:April 30, 2003 - v2
Checksum:i665110145457B220
GO

Sequence cautioni

The sequence AAH10630 differs from that shown. Reason: Frameshift at position 884.Curated
The sequence AAH42180 differs from that shown. Intron retention.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156548 mRNA. Translation: AAF09446.1.
AC069431 Genomic DNA. No translation available.
BC042180 mRNA. Translation: AAH42180.1. Sequence problems.
BC010630 mRNA. Translation: AAH10630.1. Frameshift.
AB023173 mRNA. Translation: BAA76800.1.
AL133061 mRNA. Translation: CAB61385.1.
CCDSiCCDS33896.1.
PIRiT42662.
RefSeqiNP_055431.1. NM_014616.2.
UniGeneiHs.478429.

Genome annotation databases

EnsembliENST00000323116; ENSP00000321195; ENSG00000058063.
GeneIDi23200.
KEGGihsa:23200.
UCSCiuc003fla.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156548 mRNA. Translation: AAF09446.1.
AC069431 Genomic DNA. No translation available.
BC042180 mRNA. Translation: AAH42180.1. Sequence problems.
BC010630 mRNA. Translation: AAH10630.1. Frameshift.
AB023173 mRNA. Translation: BAA76800.1.
AL133061 mRNA. Translation: CAB61385.1.
CCDSiCCDS33896.1.
PIRiT42662.
RefSeqiNP_055431.1. NM_014616.2.
UniGeneiHs.478429.

3D structure databases

ProteinModelPortaliQ9Y2G3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116809. 2 interactors.
STRINGi9606.ENSP00000321195.

Protein family/group databases

TCDBi3.A.3.8.12. the p-type atpase (p-atpase) superfamily.

PTM databases

iPTMnetiQ9Y2G3.
PhosphoSitePlusiQ9Y2G3.
SwissPalmiQ9Y2G3.

Polymorphism and mutation databases

BioMutaiATP11B.
DMDMi30316395.

Proteomic databases

EPDiQ9Y2G3.
MaxQBiQ9Y2G3.
PaxDbiQ9Y2G3.
PeptideAtlasiQ9Y2G3.
PRIDEiQ9Y2G3.

Protocols and materials databases

DNASUi23200.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000323116; ENSP00000321195; ENSG00000058063.
GeneIDi23200.
KEGGihsa:23200.
UCSCiuc003fla.3. human.

Organism-specific databases

CTDi23200.
DisGeNETi23200.
GeneCardsiATP11B.
HGNCiHGNC:13553. ATP11B.
HPAiHPA036237.
HPA036238.
MIMi605869. gene.
neXtProtiNX_Q9Y2G3.
OpenTargetsiENSG00000058063.
PharmGKBiPA25102.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0206. Eukaryota.
COG0474. LUCA.
GeneTreeiENSGT00860000133712.
HOGENOMiHOG000202528.
HOVERGENiHBG050601.
InParanoidiQ9Y2G3.
KOiK01530.
OMAiTNTEKAQ.
OrthoDBiEOG091G03B1.
PhylomeDBiQ9Y2G3.
TreeFamiTF326897.

Enzyme and pathway databases

BioCyciZFISH:HS00716-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.
R-HSA-936837. Ion transport by P-type ATPases.

Miscellaneous databases

ChiTaRSiATP11B. human.
GeneWikiiATP11B.
GenomeRNAii23200.
PROiQ9Y2G3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000058063.
CleanExiHS_ATP11B.
ExpressionAtlasiQ9Y2G3. baseline and differential.
GenevisibleiQ9Y2G3. HS.

Family and domain databases

Gene3Di2.70.150.10. 2 hits.
3.40.1110.10. 2 hits.
3.40.50.1000. 2 hits.
InterProiIPR030362. ATP11B.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006539. P-type_ATPase_IV.
IPR032631. P-type_ATPase_N.
IPR001757. P_typ_ATPase.
IPR032630. P_typ_ATPase_c.
[Graphical view]
PANTHERiPTHR24092. PTHR24092. 1 hit.
PTHR24092:SF57. PTHR24092:SF57. 1 hit.
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF16212. PhoLip_ATPase_C. 1 hit.
PF16209. PhoLip_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 2 hits.
TIGRFAMsiTIGR01652. ATPase-Plipid. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAT11B_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2G3
Secondary accession number(s): Q96FN1, Q9UKK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 30, 2003
Last modified: November 30, 2016
This is version 150 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Depletion of ATP11B by RNAi restores sensitivity of ovarian cancer cells to cisplatin.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.