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Protein

Probable phospholipid-transporting ATPase IF

Gene

ATP11B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). Involved in regulation of sensitivity to cisplatin; may contribute to secretory vesicle transport of cisplatin from Golgi to plasma membrane.Curated1 Publication

Miscellaneous

Depletion of ATP11B by RNAi restores sensitivity of ovarian cancer cells to cisplatin.

Catalytic activityi

ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei4074-aspartylphosphate intermediateBy similarity1
Metal bindingi821MagnesiumBy similarity1
Metal bindingi825MagnesiumBy similarity1

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ion transmembrane transporter activity Source: UniProtKB
  • magnesium ion binding Source: InterPro
  • phospholipid-translocating ATPase activity Source: UniProtKB

GO - Biological processi

  • aminophospholipid transport Source: UniProtKB
  • ion transmembrane transport Source: Reactome
  • ion transport Source: UniProtKB
  • neutrophil degranulation Source: Reactome
  • phospholipid translocation Source: UniProtKB

Keywordsi

Molecular functionHydrolase
Biological processLipid transport, Transport
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation
R-HSA-936837 Ion transport by P-type ATPases

Protein family/group databases

TCDBi3.A.3.8.12 the p-type atpase (p-atpase) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phospholipid-transporting ATPase IF (EC:3.6.3.1)
Alternative name(s):
ATPase IR
ATPase class VI type 11B
P4-ATPase flippase complex alpha subunit ATP11B
Gene namesi
Name:ATP11B
Synonyms:ATPIF, ATPIR, KIAA0956
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000058063.15
HGNCiHGNC:13553 ATP11B
MIMi605869 gene
neXtProtiNX_Q9Y2G3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 55CytoplasmicSequence analysisAdd BLAST55
Transmembranei56 – 77HelicalSequence analysisAdd BLAST22
Topological domaini78 – 82ExtracellularSequence analysis5
Transmembranei83 – 104HelicalSequence analysisAdd BLAST22
Topological domaini105 – 289CytoplasmicSequence analysisAdd BLAST185
Transmembranei290 – 311HelicalSequence analysisAdd BLAST22
Topological domaini312 – 341ExtracellularSequence analysisAdd BLAST30
Transmembranei342 – 359HelicalSequence analysisAdd BLAST18
Topological domaini360 – 876CytoplasmicSequence analysisAdd BLAST517
Transmembranei877 – 898HelicalSequence analysisAdd BLAST22
Topological domaini899 – 910ExtracellularSequence analysisAdd BLAST12
Transmembranei911 – 930HelicalSequence analysisAdd BLAST20
Topological domaini931 – 960CytoplasmicSequence analysisAdd BLAST30
Transmembranei961 – 982HelicalSequence analysisAdd BLAST22
Topological domaini983 – 997ExtracellularSequence analysisAdd BLAST15
Transmembranei998 – 1020HelicalSequence analysisAdd BLAST23
Topological domaini1021 – 1025CytoplasmicSequence analysis5
Transmembranei1026 – 1047HelicalSequence analysisAdd BLAST22
Topological domaini1048 – 1065ExtracellularSequence analysisAdd BLAST18
Transmembranei1066 – 1090HelicalSequence analysisAdd BLAST25
Topological domaini1091 – 1177CytoplasmicSequence analysisAdd BLAST87

Keywords - Cellular componenti

Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi23200
OpenTargetsiENSG00000058063
PharmGKBiPA25102

Polymorphism and mutation databases

BioMutaiATP11B
DMDMi30316395

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000463711 – 1177Probable phospholipid-transporting ATPase IFAdd BLAST1177

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1154PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y2G3
MaxQBiQ9Y2G3
PaxDbiQ9Y2G3
PeptideAtlasiQ9Y2G3
PRIDEiQ9Y2G3

PTM databases

iPTMnetiQ9Y2G3
PhosphoSitePlusiQ9Y2G3
SwissPalmiQ9Y2G3

Expressioni

Gene expression databases

BgeeiENSG00000058063
CleanExiHS_ATP11B
ExpressionAtlasiQ9Y2G3 baseline and differential
GenevisibleiQ9Y2G3 HS

Organism-specific databases

HPAiHPA036237
HPA036238

Interactioni

Subunit structurei

Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit and an accessory beta subunit (Probable). Interacts with beta subunit TMEM30A.Curated1 Publication

Protein-protein interaction databases

BioGridi116809, 2 interactors
STRINGi9606.ENSP00000321195

Structurei

3D structure databases

ProteinModelPortaliQ9Y2G3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0206 Eukaryota
COG0474 LUCA
GeneTreeiENSGT00910000144008
HOGENOMiHOG000202528
HOVERGENiHBG050601
InParanoidiQ9Y2G3
KOiK01530
OMAiRCSPTHV
OrthoDBiEOG091G03B1
PhylomeDBiQ9Y2G3
TreeFamiTF326897

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR030362 ATP11B
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006539 P-type_ATPase_IV
IPR032631 P-type_ATPase_N
IPR001757 P_typ_ATPase
IPR032630 P_typ_ATPase_c
PANTHERiPTHR24092 PTHR24092, 1 hit
PTHR24092:SF57 PTHR24092:SF57, 1 hit
PfamiView protein in Pfam
PF16212 PhoLip_ATPase_C, 1 hit
PF16209 PhoLip_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 3 hits
SSF81653 SSF81653, 2 hits
SSF81660 SSF81660, 2 hits
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01652 ATPase-Plipid, 1 hit
TIGR01494 ATPase_P-type, 3 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Y2G3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWRWIRQQLG FDPPHQSDTR TIYVANRFPQ NGLYTPQKFI DNRIISSKYT
60 70 80 90 100
VWNFVPKNLF EQFRRVANFY FLIIFLVQLM IDTPTSPVTS GLPLFFVITV
110 120 130 140 150
TAIKQGYEDW LRHNSDNEVN GAPVYVVRSG GLVKTRSKNI RVGDIVRIAK
160 170 180 190 200
DEIFPADLVL LSSDRLDGSC HVTTASLDGE TNLKTHVAVP ETALLQTVAN
210 220 230 240 250
LDTLVAVIEC QQPEADLYRF MGRMIITQQM EEIVRPLGPE SLLLRGARLK
260 270 280 290 300
NTKEIFGVAV YTGMETKMAL NYKSKSQKRS AVEKSMNTFL IIYLVILISE
310 320 330 340 350
AVISTILKYT WQAEEKWDEP WYNQKTEHQR NSSKILRFIS DFLAFLVLYN
360 370 380 390 400
FIIPISLYVT VEMQKFLGSF FIGWDLDLYH EESDQKAQVN TSDLNEELGQ
410 420 430 440 450
VEYVFTDKTG TLTENEMQFR ECSINGMKYQ EINGRLVPEG PTPDSSEGNL
460 470 480 490 500
SYLSSLSHLN NLSHLTTSSS FRTSPENETE LIKEHDLFFK AVSLCHTVQI
510 520 530 540 550
SNVQTDCTGD GPWQSNLAPS QLEYYASSPD EKALVEAAAR IGIVFIGNSE
560 570 580 590 600
ETMEVKTLGK LERYKLLHIL EFDSDRRRMS VIVQAPSGEK LLFAKGAESS
610 620 630 640 650
ILPKCIGGEI EKTRIHVDEF ALKGLRTLCI AYRKFTSKEY EEIDKRIFEA
660 670 680 690 700
RTALQQREEK LAAVFQFIEK DLILLGATAV EDRLQDKVRE TIEALRMAGI
710 720 730 740 750
KVWVLTGDKH ETAVSVSLSC GHFHRTMNIL ELINQKSDSE CAEQLRQLAR
760 770 780 790 800
RITEDHVIQH GLVVDGTSLS LALREHEKLF MEVCRNCSAV LCCRMAPLQK
810 820 830 840 850
AKVIRLIKIS PEKPITLAVG DGANDVSMIQ EAHVGIGIMG KEGRQAARNS
860 870 880 890 900
DYAIARFKFL SKLLFVHGHF YYIRIATLVQ YFFYKNVCFI TPQFLYQFYC
910 920 930 940 950
LFSQQTLYDS VYLTLYNICF TSLPILIYSL LEQHVDPHVL QNKPTLYRDI
960 970 980 990 1000
SKNRLLSIKT FLYWTILGFS HAFIFFFGSY LLIGKDTSLL GNGQMFGNWT
1010 1020 1030 1040 1050
FGTLVFTVMV ITVTVKMALE THFWTWINHL VTWGSIIFYF VFSLFYGGIL
1060 1070 1080 1090 1100
WPFLGSQNMY FVFIQLLSSG SAWFAIILMV VTCLFLDIIK KVFDRHLHPT
1110 1120 1130 1140 1150
STEKAQLTET NAGIKCLDSM CCFPEGEAAC ASVGRMLERV IGRCSPTHIS
1160 1170
RSWSASDPFY TNDRSILTLS TMDSSTC
Length:1,177
Mass (Da):134,190
Last modified:April 30, 2003 - v2
Checksum:i665110145457B220
GO

Sequence cautioni

The sequence AAH10630 differs from that shown. Reason: Frameshift at position 884.Curated
The sequence AAH42180 differs from that shown. Intron retention.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156548 mRNA Translation: AAF09446.1
AC069431 Genomic DNA No translation available.
BC042180 mRNA Translation: AAH42180.1 Sequence problems.
BC010630 mRNA Translation: AAH10630.1 Frameshift.
AB023173 mRNA Translation: BAA76800.1
AL133061 mRNA Translation: CAB61385.1
CCDSiCCDS33896.1
PIRiT42662
RefSeqiNP_055431.1, NM_014616.2
UniGeneiHs.478429

Genome annotation databases

EnsembliENST00000323116; ENSP00000321195; ENSG00000058063
GeneIDi23200
KEGGihsa:23200
UCSCiuc003fla.3 human

Similar proteinsi

Entry informationi

Entry nameiAT11B_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2G3
Secondary accession number(s): Q96FN1, Q9UKK7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 30, 2003
Last modified: February 28, 2018
This is version 158 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health