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Q9Y2G2

- CARD8_HUMAN

UniProt

Q9Y2G2 - CARD8_HUMAN

Protein

Caspase recruitment domain-containing protein 8

Gene

CARD8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases.

    GO - Molecular functioni

    1. cysteine-type endopeptidase activator activity involved in apoptotic process Source: HGNC
    2. NACHT domain binding Source: HGNC
    3. protein binding Source: HGNC
    4. protein homodimerization activity Source: HGNC

    GO - Biological processi

    1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: GOC
    2. negative regulation of I-kappaB kinase/NF-kappaB signaling Source: HGNC
    3. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: HGNC
    4. positive regulation of interleukin-1 beta secretion Source: HGNC

    Keywords - Biological processi

    Apoptosis

    Protein family/group databases

    MEROPSiS79.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Caspase recruitment domain-containing protein 8
    Alternative name(s):
    Apoptotic protein NDPP1
    CARD-inhibitor of NF-kappa-B-activating ligand
    Short name:
    CARDINAL
    DACAR
    Tumor up-regulated CARD-containing antagonist of CASP9
    Short name:
    TUCAN
    Gene namesi
    Name:CARD8
    Synonyms:KIAA0955, NDPP1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:17057. CARD8.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: HGNC
    2. NLRP3 inflammasome complex Source: UniProtKB
    3. nucleus Source: HGNC

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi366 – 3661L → R: Inhibits homodimer formation. 1 Publication

    Organism-specific databases

    PharmGKBiPA134916154.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 431431Caspase recruitment domain-containing protein 8PRO_0000144080Add
    BLAST

    Proteomic databases

    MaxQBiQ9Y2G2.
    PaxDbiQ9Y2G2.
    PRIDEiQ9Y2G2.

    Expressioni

    Tissue specificityi

    High expression in lung, ovary, testis and placenta. Lower expression in heart, kidney and liver. Also expressed in spleen, lymph node and bone marrow.

    Gene expression databases

    ArrayExpressiQ9Y2G2.
    BgeeiQ9Y2G2.
    CleanExiHS_CARD8.
    GenevestigatoriQ9Y2G2.

    Organism-specific databases

    HPAiHPA042071.
    HPA043513.

    Interactioni

    Subunit structurei

    May form homodimers. Interacts with NEMO and DRAL. Binds to caspase-1, CARD16/pseudo-ICE and CARD18/ICEBERG. Interacts with FNBP3 By similarity. Interacts with NALP2 NACHT domain.By similarity2 Publications

    Protein-protein interaction databases

    BioGridi116564. 4 interactions.
    IntActiQ9Y2G2. 3 interactions.
    MINTiMINT-202188.
    STRINGi9606.ENSP00000351901.

    Structurei

    Secondary structure

    1
    431
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi345 – 3506
    Helixi352 – 3587
    Helixi363 – 3719
    Helixi377 – 3859
    Beta strandi386 – 3883
    Helixi389 – 40113
    Helixi405 – 41814
    Helixi420 – 43112

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4IKMX-ray2.46A345-431[»]
    ProteinModelPortaliQ9Y2G2.
    SMRiQ9Y2G2. Positions 308-431.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini340 – 43091CARDPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 CARD domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG146295.
    HOVERGENiHBG050795.
    KOiK12801.
    OMAiHHEQWLV.
    PhylomeDBiQ9Y2G2.
    TreeFamiTF352798.

    Family and domain databases

    Gene3Di1.10.533.10. 1 hit.
    InterProiIPR001315. CARD.
    IPR011029. DEATH-like_dom.
    IPR025307. FIIND_dom.
    [Graphical view]
    PfamiPF00619. CARD. 1 hit.
    PF13553. FIIND. 1 hit.
    [Graphical view]
    SMARTiSM00114. CARD. 1 hit.
    [Graphical view]
    SUPFAMiSSF47986. SSF47986. 1 hit.
    PROSITEiPS50209. CARD. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y2G2-1) [UniParc]FASTAAdd to Basket

    Also known as: Long

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MMRQRQSHYC SVLFLSVNYL GGTFPGDICS EENQIVSSYA SKVCFEIEED    50
    YKNRQFLGPE GNVDVELIDK STNRYSVWFP TAGWYLWSAT GLGFLVRDEV 100
    TVTIAFGSWS QHLALDLQHH EQWLVGGPLF DVTAEPEEAV AEIHLPHFIS 150
    LQGEVDVSWF LVAHFKNEGM VLEHPARVEP FYAVLESPSF SLMGILLRIA 200
    SGTRLSIPIT SNTLIYYHPH PEDIKFHLYL VPSDALLTKA IDDEEDRFHG 250
    VRLQTSPPME PLNFGSSYIV SNSANLKVMP KELKLSYRSP GEIQHFSKFY 300
    AGQMKEPIQL EITEKRHGTL VWDTEVKPVD LQLVAASAPP PFSGAAFVKE 350
    NHRQLQARMG DLKGVLDDLQ DNEVLTENEK ELVEQEKTRQ SKNEALLSMV 400
    EKKGDLALDV LFRSISERDP YLVSYLRQQN L 431
    Length:431
    Mass (Da):48,933
    Last modified:November 1, 1999 - v1
    Checksum:iCB54D130807732E6
    GO
    Isoform 2 (identifier: Q9Y2G2-2) [UniParc]FASTAAdd to Basket

    Also known as: Short

    The sequence of this isoform differs from the canonical sequence as follows:
         282-286: ELKLS → WISSL
         287-431: Missing.

    Show »
    Length:286
    Mass (Da):32,369
    Checksum:iE6344DB98904F814
    GO
    Isoform 3 (identifier: Q9Y2G2-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-25: MMRQRQSHYCSVLFLSVNYLGGTFP → MEKKECPEKS...EQESSEGQDS
         152-152: Q → QA
         282-286: ELKLS → WISSL
         287-431: Missing.

    Show »
    Length:392
    Mass (Da):44,088
    Checksum:i69F2C3DF325C3043
    GO
    Isoform 4 (identifier: Q9Y2G2-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-25: MMRQRQSHYCSVLFLSVNYLGGTFP → MEKKECPEKS...EQESSEGQDS
         152-152: Q → QA

    Note: No experimental confirmation available.

    Show »
    Length:487
    Mass (Da):55,109
    Checksum:iBE398DFC6F431003
    GO
    Isoform 5 (identifier: Q9Y2G2-5) [UniParc]FASTAAdd to Basket

    Also known as: T60

    The sequence of this isoform differs from the canonical sequence as follows:
         1-25: MMRQRQSHYCSVLFLSVNYLGGTFP → MEKKECPEKS...EQESSEGQDS
         152-152: Q → QA

    Show »
    Length:537
    Mass (Da):60,652
    Checksum:i55775D025C5461BE
    GO

    Sequence cautioni

    The sequence BAA76799.2 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti60 – 601E → G in AAL02427. (PubMed:11551959)Curated
    Sequence conflicti148 – 1481F → S in AAH56891. (PubMed:15489334)Curated
    Sequence conflicti219 – 2191P → R in BAH12488. (PubMed:14702039)Curated
    Sequence conflicti326 – 3261V → M in AAL02427. (PubMed:11551959)Curated
    Sequence conflicti417 – 4171E → G in ABW96891. (PubMed:18212821)Curated
    Sequence conflicti422 – 4221L → P in AAL02427. (PubMed:11551959)Curated
    Isoform 5 (identifier: Q9Y2G2-5)
    Sequence conflicti84 – 841D → G in ABW96891. (PubMed:18212821)Curated
    Sequence conflicti107 – 1071E → D in ABW96891. (PubMed:18212821)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti68 – 681I → V.1 Publication
    Corresponds to variant rs11881179 [ dbSNP | Ensembl ].
    VAR_048606
    Natural varianti99 – 991E → A.1 Publication
    Corresponds to variant rs59878320 [ dbSNP | Ensembl ].
    VAR_061079

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 2525MMRQR…GGTFP → MEKKECPEKSSSSEEELPRR DSGSSRNIDASKLIRLQGSR KLLVDNSIRELQYTKTGIFF QAEACVTNDTVYRELPCVSE TLCDISHFFQEDDETEAEPL LFRAVPECQLSGGDIPSVSE EQESSEGQDS in isoform 3 and isoform 5. 3 PublicationsVSP_012770Add
    BLAST
    Alternative sequencei1 – 2525MMRQR…GGTFP → MEKKECPEKSSSSEEELPRR VYRELPCVSETLCDISHFFQ EDDETEAEPLLFRAVPECQL SGGDIPSVSEEQESSEGQDS in isoform 4. 1 PublicationVSP_045253Add
    BLAST
    Alternative sequencei152 – 1521Q → QA in isoform 3, isoform 4 and isoform 5. 3 PublicationsVSP_012771
    Alternative sequencei282 – 2865ELKLS → WISSL in isoform 2 and isoform 3. 3 PublicationsVSP_000782
    Alternative sequencei287 – 431145Missing in isoform 2 and isoform 3. 3 PublicationsVSP_000783Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB023172 mRNA. Translation: BAA76799.2. Different initiation.
    AF322184 mRNA. Translation: AAG50014.1.
    AF331519 mRNA. Translation: AAK01126.1.
    AY026322 mRNA. Translation: AAK08982.1.
    AF405558 mRNA. Translation: AAL02427.1.
    EU118120 mRNA. Translation: ABW96891.1.
    AF511652 mRNA. Translation: AAM46959.1.
    AK297045 mRNA. Translation: BAH12482.1.
    AK297069 mRNA. Translation: BAH12488.1.
    AC008392 Genomic DNA. No translation available.
    AC011466 Genomic DNA. No translation available.
    CH471177 Genomic DNA. Translation: EAW52321.1.
    CH471177 Genomic DNA. Translation: EAW52323.1.
    BC056891 mRNA. Translation: AAH56891.1.
    CCDSiCCDS12712.2. [Q9Y2G2-4]
    CCDS54288.1. [Q9Y2G2-3]
    CCDS54289.1. [Q9Y2G2-5]
    RefSeqiNP_001171829.1. NM_001184900.1. [Q9Y2G2-5]
    NP_001171830.1. NM_001184901.1. [Q9Y2G2-4]
    NP_001171831.1. NM_001184902.1. [Q9Y2G2-3]
    NP_001171832.1. NM_001184903.1. [Q9Y2G2-3]
    NP_055774.2. NM_014959.3. [Q9Y2G2-4]
    XP_006723154.1. XM_006723091.1. [Q9Y2G2-5]
    XP_006723155.1. XM_006723092.1. [Q9Y2G2-5]
    XP_006723156.1. XM_006723093.1. [Q9Y2G2-5]
    XP_006723158.1. XM_006723095.1. [Q9Y2G2-4]
    XP_006723159.1. XM_006723096.1. [Q9Y2G2-4]
    XP_006723160.1. XM_006723097.1. [Q9Y2G2-4]
    XP_006723167.1. XM_006723104.1. [Q9Y2G2-1]
    XP_006723169.1. XM_006723106.1. [Q9Y2G2-3]
    XP_006723172.1. XM_006723109.1. [Q9Y2G2-2]
    UniGeneiHs.446146.
    Hs.655940.

    Genome annotation databases

    EnsembliENST00000391898; ENSP00000375767; ENSG00000105483. [Q9Y2G2-5]
    ENST00000447740; ENSP00000391248; ENSG00000105483. [Q9Y2G2-4]
    ENST00000519940; ENSP00000428883; ENSG00000105483. [Q9Y2G2-5]
    ENST00000520015; ENSP00000430747; ENSG00000105483. [Q9Y2G2-3]
    ENST00000520153; ENSP00000428736; ENSG00000105483. [Q9Y2G2-4]
    ENST00000520753; ENSP00000429839; ENSG00000105483. [Q9Y2G2-3]
    ENST00000521613; ENSP00000427858; ENSG00000105483. [Q9Y2G2-4]
    GeneIDi22900.
    KEGGihsa:22900.
    UCSCiuc002pie.4. human. [Q9Y2G2-1]
    uc002pif.4. human. [Q9Y2G2-2]
    uc002pih.4. human.
    uc002pii.4. human. [Q9Y2G2-3]
    uc010xzj.2. human.

    Polymorphism databases

    DMDMi14424229.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB023172 mRNA. Translation: BAA76799.2 . Different initiation.
    AF322184 mRNA. Translation: AAG50014.1 .
    AF331519 mRNA. Translation: AAK01126.1 .
    AY026322 mRNA. Translation: AAK08982.1 .
    AF405558 mRNA. Translation: AAL02427.1 .
    EU118120 mRNA. Translation: ABW96891.1 .
    AF511652 mRNA. Translation: AAM46959.1 .
    AK297045 mRNA. Translation: BAH12482.1 .
    AK297069 mRNA. Translation: BAH12488.1 .
    AC008392 Genomic DNA. No translation available.
    AC011466 Genomic DNA. No translation available.
    CH471177 Genomic DNA. Translation: EAW52321.1 .
    CH471177 Genomic DNA. Translation: EAW52323.1 .
    BC056891 mRNA. Translation: AAH56891.1 .
    CCDSi CCDS12712.2. [Q9Y2G2-4 ]
    CCDS54288.1. [Q9Y2G2-3 ]
    CCDS54289.1. [Q9Y2G2-5 ]
    RefSeqi NP_001171829.1. NM_001184900.1. [Q9Y2G2-5 ]
    NP_001171830.1. NM_001184901.1. [Q9Y2G2-4 ]
    NP_001171831.1. NM_001184902.1. [Q9Y2G2-3 ]
    NP_001171832.1. NM_001184903.1. [Q9Y2G2-3 ]
    NP_055774.2. NM_014959.3. [Q9Y2G2-4 ]
    XP_006723154.1. XM_006723091.1. [Q9Y2G2-5 ]
    XP_006723155.1. XM_006723092.1. [Q9Y2G2-5 ]
    XP_006723156.1. XM_006723093.1. [Q9Y2G2-5 ]
    XP_006723158.1. XM_006723095.1. [Q9Y2G2-4 ]
    XP_006723159.1. XM_006723096.1. [Q9Y2G2-4 ]
    XP_006723160.1. XM_006723097.1. [Q9Y2G2-4 ]
    XP_006723167.1. XM_006723104.1. [Q9Y2G2-1 ]
    XP_006723169.1. XM_006723106.1. [Q9Y2G2-3 ]
    XP_006723172.1. XM_006723109.1. [Q9Y2G2-2 ]
    UniGenei Hs.446146.
    Hs.655940.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4IKM X-ray 2.46 A 345-431 [» ]
    ProteinModelPortali Q9Y2G2.
    SMRi Q9Y2G2. Positions 308-431.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116564. 4 interactions.
    IntActi Q9Y2G2. 3 interactions.
    MINTi MINT-202188.
    STRINGi 9606.ENSP00000351901.

    Protein family/group databases

    MEROPSi S79.001.

    Polymorphism databases

    DMDMi 14424229.

    Proteomic databases

    MaxQBi Q9Y2G2.
    PaxDbi Q9Y2G2.
    PRIDEi Q9Y2G2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000391898 ; ENSP00000375767 ; ENSG00000105483 . [Q9Y2G2-5 ]
    ENST00000447740 ; ENSP00000391248 ; ENSG00000105483 . [Q9Y2G2-4 ]
    ENST00000519940 ; ENSP00000428883 ; ENSG00000105483 . [Q9Y2G2-5 ]
    ENST00000520015 ; ENSP00000430747 ; ENSG00000105483 . [Q9Y2G2-3 ]
    ENST00000520153 ; ENSP00000428736 ; ENSG00000105483 . [Q9Y2G2-4 ]
    ENST00000520753 ; ENSP00000429839 ; ENSG00000105483 . [Q9Y2G2-3 ]
    ENST00000521613 ; ENSP00000427858 ; ENSG00000105483 . [Q9Y2G2-4 ]
    GeneIDi 22900.
    KEGGi hsa:22900.
    UCSCi uc002pie.4. human. [Q9Y2G2-1 ]
    uc002pif.4. human. [Q9Y2G2-2 ]
    uc002pih.4. human.
    uc002pii.4. human. [Q9Y2G2-3 ]
    uc010xzj.2. human.

    Organism-specific databases

    CTDi 22900.
    GeneCardsi GC19M048711.
    H-InvDB HIX0020041.
    HGNCi HGNC:17057. CARD8.
    HPAi HPA042071.
    HPA043513.
    MIMi 609051. gene.
    neXtProti NX_Q9Y2G2.
    PharmGKBi PA134916154.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG146295.
    HOVERGENi HBG050795.
    KOi K12801.
    OMAi HHEQWLV.
    PhylomeDBi Q9Y2G2.
    TreeFami TF352798.

    Miscellaneous databases

    ChiTaRSi CARD8. human.
    GeneWikii CARD8.
    GenomeRNAii 22900.
    NextBioi 43531.
    PROi Q9Y2G2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y2G2.
    Bgeei Q9Y2G2.
    CleanExi HS_CARD8.
    Genevestigatori Q9Y2G2.

    Family and domain databases

    Gene3Di 1.10.533.10. 1 hit.
    InterProi IPR001315. CARD.
    IPR011029. DEATH-like_dom.
    IPR025307. FIIND_dom.
    [Graphical view ]
    Pfami PF00619. CARD. 1 hit.
    PF13553. FIIND. 1 hit.
    [Graphical view ]
    SMARTi SM00114. CARD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47986. SSF47986. 1 hit.
    PROSITEi PS50209. CARD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis."
      Razmara M., Srinivasula S.M., Wang L., Poyet J.-L., Geddes B.J., DiStefano P.S., Bertin J., Alnemri E.S.
      J. Biol. Chem. 277:13952-13958(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH CARD16 AND CARD18.
    3. "NDPP1 is a novel CARD domain containing protein which can inhibit apoptosis and suppress NF-kappaB activation."
      Zhang H., Fu W.
      Int. J. Oncol. 20:1035-1040(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    4. "DACAR, a novel CARD-containing protein."
      Guiet C., Vito P.
      Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    5. "CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways."
      Bouchier-Hayes L., Conroy H., Egan H., Adrain C., Creagh E.M., MacFarlane M., Martin S.J.
      J. Biol. Chem. 276:44069-44077(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    6. "Novel isoforms of the CARD8 (TUCAN) gene evade a nonsense mutation."
      Bagnall R.D., Roberts R.G., Mirza M.M., Torigoe T., Prescott N.J., Mathew C.G.
      Eur. J. Hum. Genet. 16:619-625(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), ALTERNATIVE SPLICING.
    7. Guo J.H., Yu L.
      Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Kidney.
    8. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4), VARIANTS VAL-68 AND ALA-99.
      Tissue: Umbilical cord blood.
    9. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Eye.
    12. "TUCAN, an antiapoptotic caspase-associated recruitment domain family protein overexpressed in cancer."
      Pathan N., Marusawa H., Krajewska M., Matsuzawa S., Kim H., Okada K., Torii S., Kitada S., Krajewski S., Welsh K., Pio F., Godzik A., Reed J.C.
      J. Biol. Chem. 276:32220-32229(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    13. "TUCAN/CARDINAL and DRAL participate in a common pathway for modulation of NF-kappaB activation."
      Stilo R., Leonardi A., Formisano L., Di Jeso B., Vito P., Liguoro D.
      FEBS Lett. 521:165-169(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION, MUTAGENESIS OF LEU-366.
    14. "NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder."
      Agostini L., Martinon F., Burns K., McDermott M.F., Hawkins P.N., Tschopp J.
      Immunity 20:319-325(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NALP2, SUBCELLULAR LOCATION.
    15. "The structure of the CARD8 caspase-recruitment domain suggests its association with the FIIND domain and procaspases through adjacent surfaces."
      Jin T., Huang M., Smith P., Jiang J., Xiao T.S.
      Acta Crystallogr. F 69:482-487(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.46 ANGSTROMS) OF 345-431.

    Entry informationi

    Entry nameiCARD8_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y2G2
    Secondary accession number(s): B5KVR6
    , B7Z496, B7Z4A2, E9PEM7, G3XAM9, Q6PGP8, Q96P82
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 127 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3