Q9Y2G2 (CARD8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Caspase recruitment domain-containing protein 8

Alternative name(s):
Apoptotic protein NDPP1
CARD-inhibitor of NF-kappa-B-activating ligand
Short name=CARDINAL
DACAR
Tumor up-regulated CARD-containing antagonist of CASP9
Short name=TUCAN

Gene names

Name:	CARD8
Synonyms:	KIAA0955, NDPP1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	431 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases.
Subunit structure	May form homodimers. Interacts with NEMO and DRAL. Binds to caspase-1, CARD16/pseudo-ICE and CARD18/ICEBERG. Interacts with FNBP3 By similarity. Interacts with NALP2 NACHT domain. Ref.2 Ref.14
Subcellular location	Cytoplasm. Nucleus Ref.14.
Tissue specificity	High expression in lung, ovary, testis and placenta. Lower expression in heart, kidney and liver. Also expressed in spleen, lymph node and bone marrow.
Sequence similarities	Contains 1 CARD domain.
Sequence caution	The sequence BAA76799.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of I-kappaB kinase/NF-kappaB cascade Inferred from direct assay Ref.5. Source: HGNC positive regulation of interleukin-1 beta secretion Inferred from direct assay Ref.14. Source: HGNC
Cellular_component	NLRP3 inflammasome complex Inferred from direct assay Ref.14. Source: UniProtKB cytoplasm Inferred from direct assay Ref.14. Source: HGNC nucleus Inferred from direct assay Ref.5. Source: HGNC
Molecular_function	cysteine-type endopeptidase activator activity involved in apoptotic process Inferred from direct assay Ref.14. Source: HGNC protein homodimerization activity Inferred from direct assay Ref.14. Source: HGNC
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9Y2G2-1)

Also known as: Long;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Y2G2-2)

Also known as: Short;

The sequence of this isoform differs from the canonical sequence as follows:
     282-286: ELKLS → WISSL
     287-431: Missing.

Isoform 3 (identifier: Q9Y2G2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MMRQRQSHYCSVLFLSVNYLGGTFP → MEKKECPEKS...EQESSEGQDS
     152-152: Q → QA
     282-286: ELKLS → WISSL
     287-431: Missing.

Isoform 4 (identifier: Q9Y2G2-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MMRQRQSHYCSVLFLSVNYLGGTFP → MEKKECPEKS...EQESSEGQDS
     152-152: Q → QA

Note: No experimental confirmation available.

Isoform 5 (identifier: Q9Y2G2-5)

Also known as: T60;

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MMRQRQSHYCSVLFLSVNYLGGTFP → MEKKECPEKS...EQESSEGQDS
     152-152: Q → QA

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 431	431	Caspase recruitment domain-containing protein 8		PRO_0000144080
Regions
	Domain	340 – 430	91	CARD
Natural variations
	Alternative sequence	1 – 25	25	MMRQR…GGTFP → MEKKECPEKSSSSEEELPRR DSGSSRNIDASKLIRLQGSR KLLVDNSIRELQYTKTGIFF QAEACVTNDTVYRELPCVSE TLCDISHFFQEDDETEAEPL LFRAVPECQLSGGDIPSVSE EQESSEGQDS in isoform 3 and isoform 5.		VSP_012770
	Alternative sequence	1 – 25	25	MMRQR…GGTFP → MEKKECPEKSSSSEEELPRR VYRELPCVSETLCDISHFFQ EDDETEAEPLLFRAVPECQL SGGDIPSVSEEQESSEGQDS in isoform 4.		VSP_045253
	Alternative sequence	152	1	Q → QA in isoform 3, isoform 4 and isoform 5.		VSP_012771
	Alternative sequence	282 – 286	5	ELKLS → WISSL in isoform 2 and isoform 3.		VSP_000782
	Alternative sequence	287 – 431	145	Missing in isoform 2 and isoform 3.		VSP_000783
	Natural variant	68	1	I → V. Ref.8 Corresponds to variant rs11881179 [ dbSNP | Ensembl ].		VAR_048606
	Natural variant	99	1	E → A. Ref.8 Corresponds to variant rs59878320 [ dbSNP | Ensembl ].		VAR_061079
Experimental info
	Mutagenesis	366	1	L → R: Inhibits homodimer formation. Ref.13
	Sequence conflict	60	1	E → G in AAL02427. Ref.5
	Sequence conflict	148	1	F → S in AAH56891. Ref.11
	Sequence conflict	219	1	P → R in BAH12488. Ref.8
	Sequence conflict	326	1	V → M in AAL02427. Ref.5
	Sequence conflict	417	1	E → G in ABW96891. Ref.6
	Sequence conflict	422	1	L → P in AAL02427. Ref.5
Isoform 5:
	Sequence conflict	84	1	D → G in ABW96891. Ref.6
	Sequence conflict	107	1	E → D in ABW96891. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Long) [UniParc]. Last modified November 1, 1999. Version 1. Checksum: CB54D130807732E6	FASTA	431	48,933
	10 20 30 40 50 60 MMRQRQSHYC SVLFLSVNYL GGTFPGDICS EENQIVSSYA SKVCFEIEED YKNRQFLGPE 70 80 90 100 110 120 GNVDVELIDK STNRYSVWFP TAGWYLWSAT GLGFLVRDEV TVTIAFGSWS QHLALDLQHH 130 140 150 160 170 180 EQWLVGGPLF DVTAEPEEAV AEIHLPHFIS LQGEVDVSWF LVAHFKNEGM VLEHPARVEP 190 200 210 220 230 240 FYAVLESPSF SLMGILLRIA SGTRLSIPIT SNTLIYYHPH PEDIKFHLYL VPSDALLTKA 250 260 270 280 290 300 IDDEEDRFHG VRLQTSPPME PLNFGSSYIV SNSANLKVMP KELKLSYRSP GEIQHFSKFY 310 320 330 340 350 360 AGQMKEPIQL EITEKRHGTL VWDTEVKPVD LQLVAASAPP PFSGAAFVKE NHRQLQARMG 370 380 390 400 410 420 DLKGVLDDLQ DNEVLTENEK ELVEQEKTRQ SKNEALLSMV EKKGDLALDV LFRSISERDP 430 YLVSYLRQQN L
	Isoform 2 (Short) [UniParc]. Checksum: E6344DB98904F814	FASTA	286	32,369
	10 20 30 40 50 60 MMRQRQSHYC SVLFLSVNYL GGTFPGDICS EENQIVSSYA SKVCFEIEED YKNRQFLGPE 70 80 90 100 110 120 GNVDVELIDK STNRYSVWFP TAGWYLWSAT GLGFLVRDEV TVTIAFGSWS QHLALDLQHH 130 140 150 160 170 180 EQWLVGGPLF DVTAEPEEAV AEIHLPHFIS LQGEVDVSWF LVAHFKNEGM VLEHPARVEP 190 200 210 220 230 240 FYAVLESPSF SLMGILLRIA SGTRLSIPIT SNTLIYYHPH PEDIKFHLYL VPSDALLTKA 250 260 270 280 IDDEEDRFHG VRLQTSPPME PLNFGSSYIV SNSANLKVMP KWISSL
	Isoform 3 [UniParc]. Checksum: 69F2C3DF325C3043	FASTA	392	44,088
	10 20 30 40 50 60 MEKKECPEKS SSSEEELPRR DSGSSRNIDA SKLIRLQGSR KLLVDNSIRE LQYTKTGIFF 70 80 90 100 110 120 QAEACVTNDT VYRELPCVSE TLCDISHFFQ EDDETEAEPL LFRAVPECQL SGGDIPSVSE 130 140 150 160 170 180 EQESSEGQDS GDICSEENQI VSSYASKVCF EIEEDYKNRQ FLGPEGNVDV ELIDKSTNRY 190 200 210 220 230 240 SVWFPTAGWY LWSATGLGFL VRDEVTVTIA FGSWSQHLAL DLQHHEQWLV GGPLFDVTAE 250 260 270 280 290 300 PEEAVAEIHL PHFISLQAGE VDVSWFLVAH FKNEGMVLEH PARVEPFYAV LESPSFSLMG 310 320 330 340 350 360 ILLRIASGTR LSIPITSNTL IYYHPHPEDI KFHLYLVPSD ALLTKAIDDE EDRFHGVRLQ 370 380 390 TSPPMEPLNF GSSYIVSNSA NLKVMPKWIS SL
	Isoform 4 [UniParc]. Checksum: BE398DFC6F431003	FASTA	487	55,109
	10 20 30 40 50 60 MEKKECPEKS SSSEEELPRR VYRELPCVSE TLCDISHFFQ EDDETEAEPL LFRAVPECQL 70 80 90 100 110 120 SGGDIPSVSE EQESSEGQDS GDICSEENQI VSSYASKVCF EIEEDYKNRQ FLGPEGNVDV 130 140 150 160 170 180 ELIDKSTNRY SVWFPTAGWY LWSATGLGFL VRDEVTVTIA FGSWSQHLAL DLQHHEQWLV 190 200 210 220 230 240 GGPLFDVTAE PEEAVAEIHL PHFISLQAGE VDVSWFLVAH FKNEGMVLEH PARVEPFYAV 250 260 270 280 290 300 LESPSFSLMG ILLRIASGTR LSIPITSNTL IYYHPHPEDI KFHLYLVPSD ALLTKAIDDE 310 320 330 340 350 360 EDRFHGVRLQ TSPPMEPLNF GSSYIVSNSA NLKVMPKELK LSYRSPGEIQ HFSKFYAGQM 370 380 390 400 410 420 KEPIQLEITE KRHGTLVWDT EVKPVDLQLV AASAPPPFSG AAFVKENHRQ LQARMGDLKG 430 440 450 460 470 480 VLDDLQDNEV LTENEKELVE QEKTRQSKNE ALLSMVEKKG DLALDVLFRS ISERDPYLVS YLRQQNL
	Isoform 5 (T60) [UniParc]. Checksum: 55775D025C5461BE	FASTA	537	60,652
	10 20 30 40 50 60 MEKKECPEKS SSSEEELPRR DSGSSRNIDA SKLIRLQGSR KLLVDNSIRE LQYTKTGIFF 70 80 90 100 110 120 QAEACVTNDT VYRELPCVSE TLCDISHFFQ EDDETEAEPL LFRAVPECQL SGGDIPSVSE 130 140 150 160 170 180 EQESSEGQDS GDICSEENQI VSSYASKVCF EIEEDYKNRQ FLGPEGNVDV ELIDKSTNRY 190 200 210 220 230 240 SVWFPTAGWY LWSATGLGFL VRDEVTVTIA FGSWSQHLAL DLQHHEQWLV GGPLFDVTAE 250 260 270 280 290 300 PEEAVAEIHL PHFISLQAGE VDVSWFLVAH FKNEGMVLEH PARVEPFYAV LESPSFSLMG 310 320 330 340 350 360 ILLRIASGTR LSIPITSNTL IYYHPHPEDI KFHLYLVPSD ALLTKAIDDE EDRFHGVRLQ 370 380 390 400 410 420 TSPPMEPLNF GSSYIVSNSA NLKVMPKELK LSYRSPGEIQ HFSKFYAGQM KEPIQLEITE 430 440 450 460 470 480 KRHGTLVWDT EVKPVDLQLV AASAPPPFSG AAFVKENHRQ LQARMGDLKG VLDDLQDNEV 490 500 510 520 530 LTENEKELVE QEKTRQSKNE ALLSMVEKKG DLALDVLFRS ISERDPYLVS YLRQQNL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[2]	"CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis." Razmara M., Srinivasula S.M., Wang L., Poyet J.-L., Geddes B.J., DiStefano P.S., Bertin J., Alnemri E.S. J. Biol. Chem. 277:13952-13958(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH CARD16 AND CARD18.
[3]	"NDPP1 is a novel CARD domain containing protein which can inhibit apoptosis and suppress NF-kappaB activation." Zhang H., Fu W. Int. J. Oncol. 20:1035-1040(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[4]	"DACAR, a novel CARD-containing protein." Guiet C., Vito P. Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[5]	"CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways." Bouchier-Hayes L., Conroy H., Egan H., Adrain C., Creagh E.M., MacFarlane M., Martin S.J. J. Biol. Chem. 276:44069-44077(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[6]	"Novel isoforms of the CARD8 (TUCAN) gene evade a nonsense mutation." Bagnall R.D., Roberts R.G., Mirza M.M., Torigoe T., Prescott N.J., Mathew C.G. Eur. J. Hum. Genet. 16:619-625(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), ALTERNATIVE SPLICING.
[7]	Guo J.H., Yu L. Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Kidney.
[8]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4), VARIANTS VAL-68 AND ALA-99. Tissue: Umbilical cord blood.
[9]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[10]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[11]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Eye.
[12]	"TUCAN, an antiapoptotic caspase-associated recruitment domain family protein overexpressed in cancer." Pathan N., Marusawa H., Krajewska M., Matsuzawa S., Kim H., Okada K., Torii S., Kitada S., Krajewski S., Welsh K., Pio F., Godzik A., Reed J.C. J. Biol. Chem. 276:32220-32229(2001) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION.
[13]	"TUCAN/CARDINAL and DRAL participate in a common pathway for modulation of NF-kappaB activation." Stilo R., Leonardi A., Formisano L., Di Jeso B., Vito P., Liguoro D. FEBS Lett. 521:165-169(2002) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION, MUTAGENESIS OF LEU-366.
[14]	"NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder." Agostini L., Martinon F., Burns K., McDermott M.F., Hawkins P.N., Tschopp J. Immunity 20:319-325(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH NALP2, SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB023172 mRNA. Translation: BAA76799.2. Different initiation. AF322184 mRNA. Translation: AAG50014.1. AF331519 mRNA. Translation: AAK01126.1. AY026322 mRNA. Translation: AAK08982.1. AF405558 mRNA. Translation: AAL02427.1. EU118120 mRNA. Translation: ABW96891.1. AF511652 mRNA. Translation: AAM46959.1. AK297045 mRNA. Translation: BAH12482.1. AK297069 mRNA. Translation: BAH12488.1. AC008392 Genomic DNA. No translation available. AC011466 Genomic DNA. No translation available. CH471177 Genomic DNA. Translation: EAW52321.1. CH471177 Genomic DNA. Translation: EAW52323.1. BC056891 mRNA. Translation: AAH56891.1.
IPI	IPI00032131. IPI00218145. IPI00642708. IPI00942890. IPI00977493.
RefSeq	NP_001171829.1. NM_001184900.1. NP_001171830.1. NM_001184901.1. NP_001171831.1. NM_001184902.1. NP_001171832.1. NM_001184903.1. NP_055774.2. NM_014959.3.
UniGene	Hs.446146. Hs.655940.
3D structure databases
ProteinModelPortal	Q9Y2G2.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y2G2. 3 interactions.
MINT	MINT-202188.
STRING	9606.ENSP00000351901.
Protein family/group databases
MEROPS	S79.001.
Polymorphism databases
DMDM	14424229.
Proteomic databases
PaxDb	Q9Y2G2.
PRIDE	Q9Y2G2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000359009; ENSP00000351901; ENSG00000105483. ENST00000391898; ENSP00000375767; ENSG00000105483. ENST00000447740; ENSP00000391248; ENSG00000105483. ENST00000519940; ENSP00000428883; ENSG00000105483. ENST00000520015; ENSP00000430747; ENSG00000105483. ENST00000520153; ENSP00000428736; ENSG00000105483. ENST00000520753; ENSP00000429839; ENSG00000105483. ENST00000521613; ENSP00000427858; ENSG00000105483.
GeneID	22900.
KEGG	hsa:22900.
UCSC	uc002pie.4. human. uc002pif.4. human. uc002pii.4. human.
Organism-specific databases
CTD	22900.
GeneCards	GC19M048711.
H-InvDB	HIX0020041.
HGNC	HGNC:17057. CARD8.
HPA	HPA042071. HPA043513.
MIM	609051. gene.
neXtProt	NX_Q9Y2G2.
PharmGKB	PA134916154.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG146295.
HOVERGEN	HBG050795.
KO	K12801.
PhylomeDB	Q9Y2G2.
Gene expression databases
ArrayExpress	Q9Y2G2.
Bgee	Q9Y2G2.
CleanEx	HS_CARD8.
Genevestigator	Q9Y2G2.
GermOnline	ENSG00000105483. Homo sapiens.
Family and domain databases
Gene3D	1.10.533.10. 1 hit.
InterPro	IPR001315. CARD. IPR011029. DEATH-like_dom. IPR025307. FIIND_dom. [Graphical view]
Pfam	PF00619. CARD. 1 hit. PF13553. FIIND. 1 hit. [Graphical view]
SMART	SM00114. CARD. 1 hit. [Graphical view]
SUPFAM	SSF47986. DEATH_like. 1 hit.
PROSITE	PS50209. CARD. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CARD8. human.
GenomeRNAi	22900.
NextBio	43531.
SOURCE	Search...

Entry information

Entry name

CARD8_HUMAN

Accession

Primary (citable) accession number: Q9Y2G2
Secondary accession number(s): B5KVR6 , B7Z496, B7Z4A2, E9PEM7, G3XAM9, Q6PGP8, Q96P82

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 113 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.