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Protein

Caspase recruitment domain-containing protein 8

Gene

CARD8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases.

GO - Molecular functioni

  • cysteine-type endopeptidase activator activity involved in apoptotic process Source: HGNC
  • NACHT domain binding Source: HGNC
  • protein homodimerization activity Source: HGNC

GO - Biological processi

  • negative regulation of I-kappaB kinase/NF-kappaB signaling Source: HGNC
  • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: HGNC
  • positive regulation of interleukin-1 beta secretion Source: HGNC
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000105483-MONOMER.
SIGNORiQ9Y2G2.

Protein family/group databases

MEROPSiS79.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Caspase recruitment domain-containing protein 8
Alternative name(s):
Apoptotic protein NDPP1
CARD-inhibitor of NF-kappa-B-activating ligand
Short name:
CARDINAL
DACAR
Tumor up-regulated CARD-containing antagonist of CASP9
Short name:
TUCAN
Gene namesi
Name:CARD8
Synonyms:KIAA0955, NDPP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:17057. CARD8.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HGNC
  • NLRP3 inflammasome complex Source: UniProtKB
  • nucleoplasm Source: HPA
  • nucleus Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi135E → A: No effect on autocatalytic cleavage. 1 Publication1
Mutagenesisi137E → A: No effect on autocatalytic cleavage. 1 Publication1
Mutagenesisi147H → A: Severe loss of autocatalytic cleavage. 1 Publication1
Mutagenesisi164H → A: Severe loss of autocatalytic cleavage. 1 Publication1
Mutagenesisi173E → A: Partial loss of autocatalytic cleavage. 1 Publication1
Mutagenesisi174H → A: No effect on autocatalytic cleavage. 1 Publication1
Mutagenesisi189S → A: Partial loss of autocatalytic cleavage. 1 Publication1
Mutagenesisi189S → Q: No effect on autocatalytic cleavage. 1 Publication1
Mutagenesisi190F → H: Severe loss of autocatalytic cleavage. 1 Publication1
Mutagenesisi191S → A: Complete loss of autocatalytic cleavage. 1 Publication1
Mutagenesisi227H → A: No effect on autocatalytic cleavage. 1 Publication1
Mutagenesisi366L → R: Inhibits homodimer formation. 1 Publication1

Organism-specific databases

DisGeNETi22900.
OpenTargetsiENSG00000105483.
PharmGKBiPA134916154.

Polymorphism and mutation databases

BioMutaiCARD8.
DMDMi14424229.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001440801 – 431Caspase recruitment domain-containing protein 8Add BLAST431

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei190 – 191Cleavage; by autocatalysis1 Publication2

Proteomic databases

PaxDbiQ9Y2G2.
PeptideAtlasiQ9Y2G2.
PRIDEiQ9Y2G2.

Expressioni

Tissue specificityi

High expression in lung, ovary, testis and placenta. Lower expression in heart, kidney and liver. Also expressed in spleen, lymph node and bone marrow.

Gene expression databases

BgeeiENSG00000105483.
CleanExiHS_CARD8.
ExpressionAtlasiQ9Y2G2. baseline and differential.
GenevisibleiQ9Y2G2. HS.

Organism-specific databases

HPAiHPA042071.
HPA043513.

Interactioni

Subunit structurei

May form homodimers. Interacts with NEMO and DRAL. Binds to caspase-1, CARD16/pseudo-ICE and CARD18/ICEBERG. Interacts with FNBP3 (By similarity). Interacts with NALP2 NACHT domain.By similarity2 Publications

GO - Molecular functioni

  • NACHT domain binding Source: HGNC
  • protein homodimerization activity Source: HGNC

Protein-protein interaction databases

BioGridi116564. 44 interactors.
IntActiQ9Y2G2. 3 interactors.
MINTiMINT-202188.
STRINGi9606.ENSP00000375767.

Structurei

Secondary structure

1431
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi345 – 350Combined sources6
Helixi352 – 358Combined sources7
Helixi363 – 371Combined sources9
Helixi377 – 385Combined sources9
Beta strandi386 – 388Combined sources3
Helixi389 – 401Combined sources13
Helixi405 – 418Combined sources14
Helixi420 – 431Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4IKMX-ray2.46A345-431[»]
ProteinModelPortaliQ9Y2G2.
SMRiQ9Y2G2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini340 – 430CARDPROSITE-ProRule annotationAdd BLAST91

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni79 – 330FIINDCuratedAdd BLAST252

Sequence similaritiesi

Contains 1 CARD domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3573. Eukaryota.
ENOG410ZQIE. LUCA.
GeneTreeiENSGT00830000128447.
HOGENOMiHOG000082406.
HOVERGENiHBG050795.
InParanoidiQ9Y2G2.
KOiK12801.
OMAiNSANLKV.
OrthoDBiEOG091G01QH.
PhylomeDBiQ9Y2G2.
TreeFamiTF352798.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR001315. CARD.
IPR033515. CARD8.
IPR011029. DEATH-like_dom.
IPR025307. FIIND_dom.
[Graphical view]
PANTHERiPTHR24106:SF110. PTHR24106:SF110. 2 hits.
PfamiPF00619. CARD. 1 hit.
PF13553. FIIND. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y2G2-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMRQRQSHYC SVLFLSVNYL GGTFPGDICS EENQIVSSYA SKVCFEIEED
60 70 80 90 100
YKNRQFLGPE GNVDVELIDK STNRYSVWFP TAGWYLWSAT GLGFLVRDEV
110 120 130 140 150
TVTIAFGSWS QHLALDLQHH EQWLVGGPLF DVTAEPEEAV AEIHLPHFIS
160 170 180 190 200
LQGEVDVSWF LVAHFKNEGM VLEHPARVEP FYAVLESPSF SLMGILLRIA
210 220 230 240 250
SGTRLSIPIT SNTLIYYHPH PEDIKFHLYL VPSDALLTKA IDDEEDRFHG
260 270 280 290 300
VRLQTSPPME PLNFGSSYIV SNSANLKVMP KELKLSYRSP GEIQHFSKFY
310 320 330 340 350
AGQMKEPIQL EITEKRHGTL VWDTEVKPVD LQLVAASAPP PFSGAAFVKE
360 370 380 390 400
NHRQLQARMG DLKGVLDDLQ DNEVLTENEK ELVEQEKTRQ SKNEALLSMV
410 420 430
EKKGDLALDV LFRSISERDP YLVSYLRQQN L
Length:431
Mass (Da):48,933
Last modified:November 1, 1999 - v1
Checksum:iCB54D130807732E6
GO
Isoform 2 (identifier: Q9Y2G2-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     282-286: ELKLS → WISSL
     287-431: Missing.

Show »
Length:286
Mass (Da):32,369
Checksum:iE6344DB98904F814
GO
Isoform 3 (identifier: Q9Y2G2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MMRQRQSHYCSVLFLSVNYLGGTFP → MEKKECPEKS...EQESSEGQDS
     152-152: Q → QA
     282-286: ELKLS → WISSL
     287-431: Missing.

Show »
Length:392
Mass (Da):44,088
Checksum:i69F2C3DF325C3043
GO
Isoform 4 (identifier: Q9Y2G2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MMRQRQSHYCSVLFLSVNYLGGTFP → MEKKECPEKS...EQESSEGQDS
     152-152: Q → QA

Note: No experimental confirmation available.
Show »
Length:487
Mass (Da):55,109
Checksum:iBE398DFC6F431003
GO
Isoform 5 (identifier: Q9Y2G2-5) [UniParc]FASTAAdd to basket
Also known as: T60

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MMRQRQSHYCSVLFLSVNYLGGTFP → MEKKECPEKS...EQESSEGQDS
     152-152: Q → QA

Show »
Length:537
Mass (Da):60,652
Checksum:i55775D025C5461BE
GO

Sequence cautioni

The sequence BAA76799 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti60E → G in AAL02427 (PubMed:11551959).Curated1
Sequence conflicti148F → S in AAH56891 (PubMed:15489334).Curated1
Sequence conflicti219P → R in BAH12488 (PubMed:14702039).Curated1
Sequence conflicti326V → M in AAL02427 (PubMed:11551959).Curated1
Sequence conflicti417E → G in ABW96891 (PubMed:18212821).Curated1
Sequence conflicti422L → P in AAL02427 (PubMed:11551959).Curated1
Isoform 5 (identifier: Q9Y2G2-5)
Sequence conflicti84D → G in ABW96891 (PubMed:18212821).Curated1
Sequence conflicti107E → D in ABW96891 (PubMed:18212821).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04860668I → V.1 PublicationCorresponds to variant rs11881179dbSNPEnsembl.1
Natural variantiVAR_06107999E → A.1 PublicationCorresponds to variant rs59878320dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0127701 – 25MMRQR…GGTFP → MEKKECPEKSSSSEEELPRR DSGSSRNIDASKLIRLQGSR KLLVDNSIRELQYTKTGIFF QAEACVTNDTVYRELPCVSE TLCDISHFFQEDDETEAEPL LFRAVPECQLSGGDIPSVSE EQESSEGQDS in isoform 3 and isoform 5. 3 PublicationsAdd BLAST25
Alternative sequenceiVSP_0452531 – 25MMRQR…GGTFP → MEKKECPEKSSSSEEELPRR VYRELPCVSETLCDISHFFQ EDDETEAEPLLFRAVPECQL SGGDIPSVSEEQESSEGQDS in isoform 4. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_012771152Q → QA in isoform 3, isoform 4 and isoform 5. 3 Publications1
Alternative sequenceiVSP_000782282 – 286ELKLS → WISSL in isoform 2 and isoform 3. 3 Publications5
Alternative sequenceiVSP_000783287 – 431Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST145

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023172 mRNA. Translation: BAA76799.2. Different initiation.
AF322184 mRNA. Translation: AAG50014.1.
AF331519 mRNA. Translation: AAK01126.1.
AY026322 mRNA. Translation: AAK08982.1.
AF405558 mRNA. Translation: AAL02427.1.
EU118120 mRNA. Translation: ABW96891.1.
AF511652 mRNA. Translation: AAM46959.1.
AK297045 mRNA. Translation: BAH12482.1.
AK297069 mRNA. Translation: BAH12488.1.
AC008392 Genomic DNA. No translation available.
AC011466 Genomic DNA. No translation available.
CH471177 Genomic DNA. Translation: EAW52321.1.
CH471177 Genomic DNA. Translation: EAW52323.1.
BC056891 mRNA. Translation: AAH56891.1.
CCDSiCCDS12712.2. [Q9Y2G2-4]
CCDS54288.1. [Q9Y2G2-3]
CCDS54289.1. [Q9Y2G2-5]
RefSeqiNP_001171829.1. NM_001184900.1. [Q9Y2G2-5]
NP_001171830.1. NM_001184901.1. [Q9Y2G2-4]
NP_001171831.1. NM_001184902.1. [Q9Y2G2-3]
NP_001171832.1. NM_001184903.1. [Q9Y2G2-3]
NP_055774.2. NM_014959.3. [Q9Y2G2-4]
XP_006723154.1. XM_006723091.3. [Q9Y2G2-5]
XP_006723155.1. XM_006723092.3. [Q9Y2G2-5]
XP_006723156.1. XM_006723093.3. [Q9Y2G2-5]
XP_006723158.1. XM_006723095.3. [Q9Y2G2-4]
XP_006723159.1. XM_006723096.3. [Q9Y2G2-4]
XP_006723160.1. XM_006723097.3. [Q9Y2G2-4]
XP_006723167.1. XM_006723104.3. [Q9Y2G2-1]
XP_006723169.1. XM_006723106.3. [Q9Y2G2-3]
XP_006723172.1. XM_006723109.3. [Q9Y2G2-2]
XP_011524943.1. XM_011526641.2. [Q9Y2G2-5]
XP_011524944.1. XM_011526642.2. [Q9Y2G2-5]
XP_011524945.1. XM_011526643.2. [Q9Y2G2-5]
XP_011524946.1. XM_011526644.2. [Q9Y2G2-5]
XP_011524952.1. XM_011526650.2. [Q9Y2G2-3]
XP_016881972.1. XM_017026483.1. [Q9Y2G2-4]
XP_016881979.1. XM_017026490.1. [Q9Y2G2-3]
XP_016881987.1. XM_017026498.1. [Q9Y2G2-2]
UniGeneiHs.446146.
Hs.655940.
Hs.68846.

Genome annotation databases

EnsembliENST00000391898; ENSP00000375767; ENSG00000105483. [Q9Y2G2-5]
ENST00000447740; ENSP00000391248; ENSG00000105483. [Q9Y2G2-4]
ENST00000519940; ENSP00000428883; ENSG00000105483. [Q9Y2G2-5]
ENST00000520015; ENSP00000430747; ENSG00000105483. [Q9Y2G2-3]
ENST00000520153; ENSP00000428736; ENSG00000105483. [Q9Y2G2-4]
ENST00000520753; ENSP00000429839; ENSG00000105483. [Q9Y2G2-3]
ENST00000521613; ENSP00000427858; ENSG00000105483. [Q9Y2G2-4]
GeneIDi22900.
KEGGihsa:22900.
UCSCiuc002pih.5. human. [Q9Y2G2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023172 mRNA. Translation: BAA76799.2. Different initiation.
AF322184 mRNA. Translation: AAG50014.1.
AF331519 mRNA. Translation: AAK01126.1.
AY026322 mRNA. Translation: AAK08982.1.
AF405558 mRNA. Translation: AAL02427.1.
EU118120 mRNA. Translation: ABW96891.1.
AF511652 mRNA. Translation: AAM46959.1.
AK297045 mRNA. Translation: BAH12482.1.
AK297069 mRNA. Translation: BAH12488.1.
AC008392 Genomic DNA. No translation available.
AC011466 Genomic DNA. No translation available.
CH471177 Genomic DNA. Translation: EAW52321.1.
CH471177 Genomic DNA. Translation: EAW52323.1.
BC056891 mRNA. Translation: AAH56891.1.
CCDSiCCDS12712.2. [Q9Y2G2-4]
CCDS54288.1. [Q9Y2G2-3]
CCDS54289.1. [Q9Y2G2-5]
RefSeqiNP_001171829.1. NM_001184900.1. [Q9Y2G2-5]
NP_001171830.1. NM_001184901.1. [Q9Y2G2-4]
NP_001171831.1. NM_001184902.1. [Q9Y2G2-3]
NP_001171832.1. NM_001184903.1. [Q9Y2G2-3]
NP_055774.2. NM_014959.3. [Q9Y2G2-4]
XP_006723154.1. XM_006723091.3. [Q9Y2G2-5]
XP_006723155.1. XM_006723092.3. [Q9Y2G2-5]
XP_006723156.1. XM_006723093.3. [Q9Y2G2-5]
XP_006723158.1. XM_006723095.3. [Q9Y2G2-4]
XP_006723159.1. XM_006723096.3. [Q9Y2G2-4]
XP_006723160.1. XM_006723097.3. [Q9Y2G2-4]
XP_006723167.1. XM_006723104.3. [Q9Y2G2-1]
XP_006723169.1. XM_006723106.3. [Q9Y2G2-3]
XP_006723172.1. XM_006723109.3. [Q9Y2G2-2]
XP_011524943.1. XM_011526641.2. [Q9Y2G2-5]
XP_011524944.1. XM_011526642.2. [Q9Y2G2-5]
XP_011524945.1. XM_011526643.2. [Q9Y2G2-5]
XP_011524946.1. XM_011526644.2. [Q9Y2G2-5]
XP_011524952.1. XM_011526650.2. [Q9Y2G2-3]
XP_016881972.1. XM_017026483.1. [Q9Y2G2-4]
XP_016881979.1. XM_017026490.1. [Q9Y2G2-3]
XP_016881987.1. XM_017026498.1. [Q9Y2G2-2]
UniGeneiHs.446146.
Hs.655940.
Hs.68846.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4IKMX-ray2.46A345-431[»]
ProteinModelPortaliQ9Y2G2.
SMRiQ9Y2G2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116564. 44 interactors.
IntActiQ9Y2G2. 3 interactors.
MINTiMINT-202188.
STRINGi9606.ENSP00000375767.

Protein family/group databases

MEROPSiS79.001.

Polymorphism and mutation databases

BioMutaiCARD8.
DMDMi14424229.

Proteomic databases

PaxDbiQ9Y2G2.
PeptideAtlasiQ9Y2G2.
PRIDEiQ9Y2G2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000391898; ENSP00000375767; ENSG00000105483. [Q9Y2G2-5]
ENST00000447740; ENSP00000391248; ENSG00000105483. [Q9Y2G2-4]
ENST00000519940; ENSP00000428883; ENSG00000105483. [Q9Y2G2-5]
ENST00000520015; ENSP00000430747; ENSG00000105483. [Q9Y2G2-3]
ENST00000520153; ENSP00000428736; ENSG00000105483. [Q9Y2G2-4]
ENST00000520753; ENSP00000429839; ENSG00000105483. [Q9Y2G2-3]
ENST00000521613; ENSP00000427858; ENSG00000105483. [Q9Y2G2-4]
GeneIDi22900.
KEGGihsa:22900.
UCSCiuc002pih.5. human. [Q9Y2G2-1]

Organism-specific databases

CTDi22900.
DisGeNETi22900.
GeneCardsiCARD8.
H-InvDBHIX0020041.
HGNCiHGNC:17057. CARD8.
HPAiHPA042071.
HPA043513.
MIMi609051. gene.
neXtProtiNX_Q9Y2G2.
OpenTargetsiENSG00000105483.
PharmGKBiPA134916154.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3573. Eukaryota.
ENOG410ZQIE. LUCA.
GeneTreeiENSGT00830000128447.
HOGENOMiHOG000082406.
HOVERGENiHBG050795.
InParanoidiQ9Y2G2.
KOiK12801.
OMAiNSANLKV.
OrthoDBiEOG091G01QH.
PhylomeDBiQ9Y2G2.
TreeFamiTF352798.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000105483-MONOMER.
SIGNORiQ9Y2G2.

Miscellaneous databases

ChiTaRSiCARD8. human.
GeneWikiiCARD8.
GenomeRNAii22900.
PROiQ9Y2G2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105483.
CleanExiHS_CARD8.
ExpressionAtlasiQ9Y2G2. baseline and differential.
GenevisibleiQ9Y2G2. HS.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR001315. CARD.
IPR033515. CARD8.
IPR011029. DEATH-like_dom.
IPR025307. FIIND_dom.
[Graphical view]
PANTHERiPTHR24106:SF110. PTHR24106:SF110. 2 hits.
PfamiPF00619. CARD. 1 hit.
PF13553. FIIND. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCARD8_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2G2
Secondary accession number(s): B5KVR6
, B7Z496, B7Z4A2, E9PEM7, G3XAM9, Q6PGP8, Q96P82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 149 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.