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Q9Y2G2

- CARD8_HUMAN

UniProt

Q9Y2G2 - CARD8_HUMAN

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Protein
Caspase recruitment domain-containing protein 8
Gene
CARD8, KIAA0955, NDPP1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases.

GO - Molecular functioni

  1. NACHT domain binding Source: HGNC
  2. cysteine-type endopeptidase activator activity involved in apoptotic process Source: HGNC
  3. protein binding Source: HGNC
  4. protein homodimerization activity Source: HGNC
Complete GO annotation...

GO - Biological processi

  1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: GOC
  2. negative regulation of I-kappaB kinase/NF-kappaB signaling Source: HGNC
  3. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: HGNC
  4. positive regulation of interleukin-1 beta secretion Source: HGNC
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS79.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Caspase recruitment domain-containing protein 8
Alternative name(s):
Apoptotic protein NDPP1
CARD-inhibitor of NF-kappa-B-activating ligand
Short name:
CARDINAL
DACAR
Tumor up-regulated CARD-containing antagonist of CASP9
Short name:
TUCAN
Gene namesi
Name:CARD8
Synonyms:KIAA0955, NDPP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:17057. CARD8.

Subcellular locationi

Cytoplasm. Nucleus 1 Publication

GO - Cellular componenti

  1. NLRP3 inflammasome complex Source: UniProtKB
  2. cytoplasm Source: HGNC
  3. nucleus Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi366 – 3661L → R: Inhibits homodimer formation. 1 Publication

Organism-specific databases

PharmGKBiPA134916154.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 431431Caspase recruitment domain-containing protein 8
PRO_0000144080Add
BLAST

Proteomic databases

MaxQBiQ9Y2G2.
PaxDbiQ9Y2G2.
PRIDEiQ9Y2G2.

Expressioni

Tissue specificityi

High expression in lung, ovary, testis and placenta. Lower expression in heart, kidney and liver. Also expressed in spleen, lymph node and bone marrow.

Gene expression databases

ArrayExpressiQ9Y2G2.
BgeeiQ9Y2G2.
CleanExiHS_CARD8.
GenevestigatoriQ9Y2G2.

Organism-specific databases

HPAiHPA042071.
HPA043513.

Interactioni

Subunit structurei

May form homodimers. Interacts with NEMO and DRAL. Binds to caspase-1, CARD16/pseudo-ICE and CARD18/ICEBERG. Interacts with FNBP3 By similarity. Interacts with NALP2 NACHT domain.2 Publications

Protein-protein interaction databases

BioGridi116564. 4 interactions.
IntActiQ9Y2G2. 3 interactions.
MINTiMINT-202188.
STRINGi9606.ENSP00000351901.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi345 – 3506
Helixi352 – 3587
Helixi363 – 3719
Helixi377 – 3859
Beta strandi386 – 3883
Helixi389 – 40113
Helixi405 – 41814
Helixi420 – 43112

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4IKMX-ray2.46A345-431[»]
ProteinModelPortaliQ9Y2G2.
SMRiQ9Y2G2. Positions 308-431.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini340 – 43091CARD
Add
BLAST

Sequence similaritiesi

Contains 1 CARD domain.

Phylogenomic databases

eggNOGiNOG146295.
HOVERGENiHBG050795.
KOiK12801.
OMAiHHEQWLV.
PhylomeDBiQ9Y2G2.
TreeFamiTF352798.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR001315. CARD.
IPR011029. DEATH-like_dom.
IPR025307. FIIND_dom.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
PF13553. FIIND. 1 hit.
[Graphical view]
SMARTiSM00114. CARD. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9Y2G2-1) [UniParc]FASTAAdd to Basket

Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MMRQRQSHYC SVLFLSVNYL GGTFPGDICS EENQIVSSYA SKVCFEIEED    50
YKNRQFLGPE GNVDVELIDK STNRYSVWFP TAGWYLWSAT GLGFLVRDEV 100
TVTIAFGSWS QHLALDLQHH EQWLVGGPLF DVTAEPEEAV AEIHLPHFIS 150
LQGEVDVSWF LVAHFKNEGM VLEHPARVEP FYAVLESPSF SLMGILLRIA 200
SGTRLSIPIT SNTLIYYHPH PEDIKFHLYL VPSDALLTKA IDDEEDRFHG 250
VRLQTSPPME PLNFGSSYIV SNSANLKVMP KELKLSYRSP GEIQHFSKFY 300
AGQMKEPIQL EITEKRHGTL VWDTEVKPVD LQLVAASAPP PFSGAAFVKE 350
NHRQLQARMG DLKGVLDDLQ DNEVLTENEK ELVEQEKTRQ SKNEALLSMV 400
EKKGDLALDV LFRSISERDP YLVSYLRQQN L 431
Length:431
Mass (Da):48,933
Last modified:November 1, 1999 - v1
Checksum:iCB54D130807732E6
GO
Isoform 2 (identifier: Q9Y2G2-2) [UniParc]FASTAAdd to Basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     282-286: ELKLS → WISSL
     287-431: Missing.

Show »
Length:286
Mass (Da):32,369
Checksum:iE6344DB98904F814
GO
Isoform 3 (identifier: Q9Y2G2-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MMRQRQSHYCSVLFLSVNYLGGTFP → MEKKECPEKS...EQESSEGQDS
     152-152: Q → QA
     282-286: ELKLS → WISSL
     287-431: Missing.

Show »
Length:392
Mass (Da):44,088
Checksum:i69F2C3DF325C3043
GO
Isoform 4 (identifier: Q9Y2G2-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MMRQRQSHYCSVLFLSVNYLGGTFP → MEKKECPEKS...EQESSEGQDS
     152-152: Q → QA

Note: No experimental confirmation available.

Show »
Length:487
Mass (Da):55,109
Checksum:iBE398DFC6F431003
GO
Isoform 5 (identifier: Q9Y2G2-5) [UniParc]FASTAAdd to Basket

Also known as: T60

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MMRQRQSHYCSVLFLSVNYLGGTFP → MEKKECPEKS...EQESSEGQDS
     152-152: Q → QA

Show »
Length:537
Mass (Da):60,652
Checksum:i55775D025C5461BE
GO

Sequence cautioni

The sequence BAA76799.2 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti68 – 681I → V.1 Publication
Corresponds to variant rs11881179 [ dbSNP | Ensembl ].
VAR_048606
Natural varianti99 – 991E → A.1 Publication
Corresponds to variant rs59878320 [ dbSNP | Ensembl ].
VAR_061079

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2525MMRQR…GGTFP → MEKKECPEKSSSSEEELPRR DSGSSRNIDASKLIRLQGSR KLLVDNSIRELQYTKTGIFF QAEACVTNDTVYRELPCVSE TLCDISHFFQEDDETEAEPL LFRAVPECQLSGGDIPSVSE EQESSEGQDS in isoform 3 and isoform 5.
VSP_012770Add
BLAST
Alternative sequencei1 – 2525MMRQR…GGTFP → MEKKECPEKSSSSEEELPRR VYRELPCVSETLCDISHFFQ EDDETEAEPLLFRAVPECQL SGGDIPSVSEEQESSEGQDS in isoform 4.
VSP_045253Add
BLAST
Alternative sequencei152 – 1521Q → QA in isoform 3, isoform 4 and isoform 5.
VSP_012771
Alternative sequencei282 – 2865ELKLS → WISSL in isoform 2 and isoform 3.
VSP_000782
Alternative sequencei287 – 431145Missing in isoform 2 and isoform 3.
VSP_000783Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti60 – 601E → G in AAL02427. 1 Publication
Sequence conflicti148 – 1481F → S in AAH56891. 1 Publication
Sequence conflicti219 – 2191P → R in BAH12488. 1 Publication
Sequence conflicti326 – 3261V → M in AAL02427. 1 Publication
Sequence conflicti417 – 4171E → G in ABW96891. 1 Publication
Sequence conflicti422 – 4221L → P in AAL02427. 1 Publication
Isoform 5 (identifier: Q9Y2G2-5)
Sequence conflicti84 – 841D → G in ABW96891. 1 Publication
Sequence conflicti107 – 1071E → D in ABW96891. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB023172 mRNA. Translation: BAA76799.2. Different initiation.
AF322184 mRNA. Translation: AAG50014.1.
AF331519 mRNA. Translation: AAK01126.1.
AY026322 mRNA. Translation: AAK08982.1.
AF405558 mRNA. Translation: AAL02427.1.
EU118120 mRNA. Translation: ABW96891.1.
AF511652 mRNA. Translation: AAM46959.1.
AK297045 mRNA. Translation: BAH12482.1.
AK297069 mRNA. Translation: BAH12488.1.
AC008392 Genomic DNA. No translation available.
AC011466 Genomic DNA. No translation available.
CH471177 Genomic DNA. Translation: EAW52321.1.
CH471177 Genomic DNA. Translation: EAW52323.1.
BC056891 mRNA. Translation: AAH56891.1.
CCDSiCCDS12712.2. [Q9Y2G2-4]
CCDS54288.1. [Q9Y2G2-3]
CCDS54289.1. [Q9Y2G2-5]
RefSeqiNP_001171829.1. NM_001184900.1. [Q9Y2G2-5]
NP_001171830.1. NM_001184901.1. [Q9Y2G2-4]
NP_001171831.1. NM_001184902.1. [Q9Y2G2-3]
NP_001171832.1. NM_001184903.1. [Q9Y2G2-3]
NP_055774.2. NM_014959.3. [Q9Y2G2-4]
XP_006723154.1. XM_006723091.1. [Q9Y2G2-5]
XP_006723155.1. XM_006723092.1. [Q9Y2G2-5]
XP_006723156.1. XM_006723093.1. [Q9Y2G2-5]
XP_006723158.1. XM_006723095.1. [Q9Y2G2-4]
XP_006723159.1. XM_006723096.1. [Q9Y2G2-4]
XP_006723160.1. XM_006723097.1. [Q9Y2G2-4]
XP_006723167.1. XM_006723104.1. [Q9Y2G2-1]
XP_006723169.1. XM_006723106.1. [Q9Y2G2-3]
XP_006723172.1. XM_006723109.1. [Q9Y2G2-2]
UniGeneiHs.446146.
Hs.655940.

Genome annotation databases

EnsembliENST00000359009; ENSP00000351901; ENSG00000105483. [Q9Y2G2-1]
ENST00000391898; ENSP00000375767; ENSG00000105483. [Q9Y2G2-5]
ENST00000447740; ENSP00000391248; ENSG00000105483. [Q9Y2G2-4]
ENST00000519940; ENSP00000428883; ENSG00000105483. [Q9Y2G2-5]
ENST00000520015; ENSP00000430747; ENSG00000105483. [Q9Y2G2-3]
ENST00000520153; ENSP00000428736; ENSG00000105483. [Q9Y2G2-4]
ENST00000520753; ENSP00000429839; ENSG00000105483. [Q9Y2G2-3]
ENST00000521613; ENSP00000427858; ENSG00000105483. [Q9Y2G2-4]
GeneIDi22900.
KEGGihsa:22900.
UCSCiuc002pie.4. human. [Q9Y2G2-1]
uc002pif.4. human. [Q9Y2G2-2]
uc002pih.4. human.
uc002pii.4. human. [Q9Y2G2-3]
uc010xzj.2. human.

Polymorphism databases

DMDMi14424229.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB023172 mRNA. Translation: BAA76799.2 . Different initiation.
AF322184 mRNA. Translation: AAG50014.1 .
AF331519 mRNA. Translation: AAK01126.1 .
AY026322 mRNA. Translation: AAK08982.1 .
AF405558 mRNA. Translation: AAL02427.1 .
EU118120 mRNA. Translation: ABW96891.1 .
AF511652 mRNA. Translation: AAM46959.1 .
AK297045 mRNA. Translation: BAH12482.1 .
AK297069 mRNA. Translation: BAH12488.1 .
AC008392 Genomic DNA. No translation available.
AC011466 Genomic DNA. No translation available.
CH471177 Genomic DNA. Translation: EAW52321.1 .
CH471177 Genomic DNA. Translation: EAW52323.1 .
BC056891 mRNA. Translation: AAH56891.1 .
CCDSi CCDS12712.2. [Q9Y2G2-4 ]
CCDS54288.1. [Q9Y2G2-3 ]
CCDS54289.1. [Q9Y2G2-5 ]
RefSeqi NP_001171829.1. NM_001184900.1. [Q9Y2G2-5 ]
NP_001171830.1. NM_001184901.1. [Q9Y2G2-4 ]
NP_001171831.1. NM_001184902.1. [Q9Y2G2-3 ]
NP_001171832.1. NM_001184903.1. [Q9Y2G2-3 ]
NP_055774.2. NM_014959.3. [Q9Y2G2-4 ]
XP_006723154.1. XM_006723091.1. [Q9Y2G2-5 ]
XP_006723155.1. XM_006723092.1. [Q9Y2G2-5 ]
XP_006723156.1. XM_006723093.1. [Q9Y2G2-5 ]
XP_006723158.1. XM_006723095.1. [Q9Y2G2-4 ]
XP_006723159.1. XM_006723096.1. [Q9Y2G2-4 ]
XP_006723160.1. XM_006723097.1. [Q9Y2G2-4 ]
XP_006723167.1. XM_006723104.1. [Q9Y2G2-1 ]
XP_006723169.1. XM_006723106.1. [Q9Y2G2-3 ]
XP_006723172.1. XM_006723109.1. [Q9Y2G2-2 ]
UniGenei Hs.446146.
Hs.655940.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4IKM X-ray 2.46 A 345-431 [» ]
ProteinModelPortali Q9Y2G2.
SMRi Q9Y2G2. Positions 308-431.
ModBasei Search...

Protein-protein interaction databases

BioGridi 116564. 4 interactions.
IntActi Q9Y2G2. 3 interactions.
MINTi MINT-202188.
STRINGi 9606.ENSP00000351901.

Protein family/group databases

MEROPSi S79.001.

Polymorphism databases

DMDMi 14424229.

Proteomic databases

MaxQBi Q9Y2G2.
PaxDbi Q9Y2G2.
PRIDEi Q9Y2G2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000359009 ; ENSP00000351901 ; ENSG00000105483 . [Q9Y2G2-1 ]
ENST00000391898 ; ENSP00000375767 ; ENSG00000105483 . [Q9Y2G2-5 ]
ENST00000447740 ; ENSP00000391248 ; ENSG00000105483 . [Q9Y2G2-4 ]
ENST00000519940 ; ENSP00000428883 ; ENSG00000105483 . [Q9Y2G2-5 ]
ENST00000520015 ; ENSP00000430747 ; ENSG00000105483 . [Q9Y2G2-3 ]
ENST00000520153 ; ENSP00000428736 ; ENSG00000105483 . [Q9Y2G2-4 ]
ENST00000520753 ; ENSP00000429839 ; ENSG00000105483 . [Q9Y2G2-3 ]
ENST00000521613 ; ENSP00000427858 ; ENSG00000105483 . [Q9Y2G2-4 ]
GeneIDi 22900.
KEGGi hsa:22900.
UCSCi uc002pie.4. human. [Q9Y2G2-1 ]
uc002pif.4. human. [Q9Y2G2-2 ]
uc002pih.4. human.
uc002pii.4. human. [Q9Y2G2-3 ]
uc010xzj.2. human.

Organism-specific databases

CTDi 22900.
GeneCardsi GC19M048711.
H-InvDB HIX0020041.
HGNCi HGNC:17057. CARD8.
HPAi HPA042071.
HPA043513.
MIMi 609051. gene.
neXtProti NX_Q9Y2G2.
PharmGKBi PA134916154.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG146295.
HOVERGENi HBG050795.
KOi K12801.
OMAi HHEQWLV.
PhylomeDBi Q9Y2G2.
TreeFami TF352798.

Miscellaneous databases

ChiTaRSi CARD8. human.
GeneWikii CARD8.
GenomeRNAii 22900.
NextBioi 43531.
PROi Q9Y2G2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9Y2G2.
Bgeei Q9Y2G2.
CleanExi HS_CARD8.
Genevestigatori Q9Y2G2.

Family and domain databases

Gene3Di 1.10.533.10. 1 hit.
InterProi IPR001315. CARD.
IPR011029. DEATH-like_dom.
IPR025307. FIIND_dom.
[Graphical view ]
Pfami PF00619. CARD. 1 hit.
PF13553. FIIND. 1 hit.
[Graphical view ]
SMARTi SM00114. CARD. 1 hit.
[Graphical view ]
SUPFAMi SSF47986. SSF47986. 1 hit.
PROSITEi PS50209. CARD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis."
    Razmara M., Srinivasula S.M., Wang L., Poyet J.-L., Geddes B.J., DiStefano P.S., Bertin J., Alnemri E.S.
    J. Biol. Chem. 277:13952-13958(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH CARD16 AND CARD18.
  3. "NDPP1 is a novel CARD domain containing protein which can inhibit apoptosis and suppress NF-kappaB activation."
    Zhang H., Fu W.
    Int. J. Oncol. 20:1035-1040(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. "DACAR, a novel CARD-containing protein."
    Guiet C., Vito P.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  5. "CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways."
    Bouchier-Hayes L., Conroy H., Egan H., Adrain C., Creagh E.M., MacFarlane M., Martin S.J.
    J. Biol. Chem. 276:44069-44077(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  6. "Novel isoforms of the CARD8 (TUCAN) gene evade a nonsense mutation."
    Bagnall R.D., Roberts R.G., Mirza M.M., Torigoe T., Prescott N.J., Mathew C.G.
    Eur. J. Hum. Genet. 16:619-625(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), ALTERNATIVE SPLICING.
  7. Guo J.H., Yu L.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Kidney.
  8. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4), VARIANTS VAL-68 AND ALA-99.
    Tissue: Umbilical cord blood.
  9. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Eye.
  12. "TUCAN, an antiapoptotic caspase-associated recruitment domain family protein overexpressed in cancer."
    Pathan N., Marusawa H., Krajewska M., Matsuzawa S., Kim H., Okada K., Torii S., Kitada S., Krajewski S., Welsh K., Pio F., Godzik A., Reed J.C.
    J. Biol. Chem. 276:32220-32229(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  13. "TUCAN/CARDINAL and DRAL participate in a common pathway for modulation of NF-kappaB activation."
    Stilo R., Leonardi A., Formisano L., Di Jeso B., Vito P., Liguoro D.
    FEBS Lett. 521:165-169(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION, MUTAGENESIS OF LEU-366.
  14. "NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder."
    Agostini L., Martinon F., Burns K., McDermott M.F., Hawkins P.N., Tschopp J.
    Immunity 20:319-325(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NALP2, SUBCELLULAR LOCATION.
  15. "The structure of the CARD8 caspase-recruitment domain suggests its association with the FIIND domain and procaspases through adjacent surfaces."
    Jin T., Huang M., Smith P., Jiang J., Xiao T.S.
    Acta Crystallogr. F 69:482-487(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.46 ANGSTROMS) OF 345-431.

Entry informationi

Entry nameiCARD8_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2G2
Secondary accession number(s): B5KVR6
, B7Z496, B7Z4A2, E9PEM7, G3XAM9, Q6PGP8, Q96P82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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