MYRF

Functionⁱ

Myelin regulatory factor: Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates transcription of central nervous system (CNS) myelin genes (PubMed:23966832).1 Publication

Myelin regulatory factor, C-terminal: Membrane-bound part that has no transcription factor activity and remains attached to the endoplasmic reticulum membrane following cleavage.1 Publication

Myelin regulatory factor, N-terminal: Transcription factor that specifically activates expression of myelin genes such as MBP, MOG, MAG, DUSP15 and PLP1 during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Specifically recognizes and binds DNA sequence 5'-CTGGYAC-3' in the regulatory regions of myelin-specific genes and directly activates their expression. Not only required during oligodendrocyte differentiation but is also required on an ongoing basis for the maintenance of expression of myelin genes and for the maintenance of a mature, viable oligodendrocyte phenotype (PubMed:23966832).1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	250 – 541	NDT80PROSITE-ProRule annotationAdd BLAST		292

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
peptidase activity Source: UniProtKB-KW
transcription factor activity, sequence-specific DNA binding Source: InterPro

Complete GO annotation...

GO - Biological processⁱ

central nervous system myelination Source: UniProtKB
central nervous system myelin maintenance Source: UniProtKB
oligodendrocyte development Source: UniProtKB
oligodendrocyte differentiation Source: UniProtKB
positive regulation of myelination Source: UniProtKB
positive regulation of transcription, DNA-templated Source: UniProtKB
transcription, DNA-templated Source: UniProtKB-KW

Complete GO annotation...

Keywordsⁱ

Molecular function	Activator, DNA-binding, Hydrolase, Protease
Biological process	Differentiation, Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Myelin regulatory factor (EC:3.4.-.-) Alternative name(s): Myelin gene regulatory factor Cleaved into the following 2 chains: Myelin regulatory factor, N-terminal Myelin regulatory factor, C-terminal
Gene namesⁱ	Name:MYRF Synonyms:C11orf9, KIAA0954, MRF
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1181. MYRF.

HGNCⁱ

HGNC:1181. MYRF.

Subcellular locationⁱ

Myelin regulatory factor :

Endoplasmic reticulum membrane
1 Publication
Manual assertion based on experiment inⁱ
- Ref.7
  "A bacteriophage tailspike domain promotes self-cleavage of a human membrane-bound transcription factor, the myelin regulatory factor MYRF."
  Li Z., Park Y., Marcotte E.M.
  PLoS Biol. 11:E1001624-E1001624(2013) [PubMed] [Europe PMC] [Abstract]
  Cited for: SUBCELLULAR LOCATION, SUBUNIT, PROTEOLYTIC PROCESSING, GLYCOSYLATION, AUTOCATALYTIC CLEAVAGE, TOPOLOGY, MUTAGENESIS OF SER-587; ASP-588; LYS-592; SER-608; GLY-635; LEU-688 AND LEU-699, FUNCTION, DOMAIN.
; Single-pass membrane protein

Myelin regulatory factor, N-terminal :

Note:

Translocates from the cytoplasm to the nucleus upon autocatalytic cleavage.1 Publication

Myelin regulatory factor, C-terminal :

Endoplasmic reticulum membrane
1 Publication
Manual assertion based on experiment inⁱ
- Ref.7
  "A bacteriophage tailspike domain promotes self-cleavage of a human membrane-bound transcription factor, the myelin regulatory factor MYRF."
  Li Z., Park Y., Marcotte E.M.
  PLoS Biol. 11:E1001624-E1001624(2013) [PubMed] [Europe PMC] [Abstract]
  Cited for: SUBCELLULAR LOCATION, SUBUNIT, PROTEOLYTIC PROCESSING, GLYCOSYLATION, AUTOCATALYTIC CLEAVAGE, TOPOLOGY, MUTAGENESIS OF SER-587; ASP-588; LYS-592; SER-608; GLY-635; LEU-688 AND LEU-699, FUNCTION, DOMAIN.
; Single-pass membrane protein
1 Publication
Manual assertion based on experiment inⁱ
- Ref.7
  "A bacteriophage tailspike domain promotes self-cleavage of a human membrane-bound transcription factor, the myelin regulatory factor MYRF."
  Li Z., Park Y., Marcotte E.M.
  PLoS Biol. 11:E1001624-E1001624(2013) [PubMed] [Europe PMC] [Abstract]
  Cited for: SUBCELLULAR LOCATION, SUBUNIT, PROTEOLYTIC PROCESSING, GLYCOSYLATION, AUTOCATALYTIC CLEAVAGE, TOPOLOGY, MUTAGENESIS OF SER-587; ASP-588; LYS-592; SER-608; GLY-635; LEU-688 AND LEU-699, FUNCTION, DOMAIN.

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 768	CytoplasmicSequence analysisAdd BLAST	768
Transmembraneⁱ	769 – 789	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	790 – 1151	LumenalSequence analysisAdd BLAST	362

GO - Cellular componentⁱ

cytosol Source: HPA
endoplasmic reticulum membrane Source: UniProtKB-SubCell
Golgi apparatus Source: HPA
integral component of membrane Source: UniProtKB-KW
nucleoplasm Source: HPA
nucleus Source: UniProtKB

Complete GO annotation...

Keywords - Cellular componentⁱ

Cytoplasm, Endoplasmic reticulum, Membrane, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	587	S → A: Prevents autocatalytic cleavage and generation of Myelin regulatory factor, N-terminal part. 1 Publication	1
Mutagenesisⁱ	588	D → A: Reduces autocatalytic cleavage and generation of Myelin regulatory factor, N-terminal part. 1 Publication	1
Mutagenesisⁱ	592	K → A: Prevents autocatalytic cleavage and generation of Myelin regulatory factor, N-terminal part. 1 Publication	1
Mutagenesisⁱ	608	S → A: Does not affect autocatalytic cleavage. 1 Publication	1
Mutagenesisⁱ	635	G → A: Reduces autocatalytic cleavage and generation of Myelin regulatory factor, N-terminal part. 1 Publication	1
Mutagenesisⁱ	688	L → A: Does not affect autocatalytic cleavage. 1 Publication	1
Mutagenesisⁱ	699	L → A: Prevents autocatalytic cleavage and generation of Myelin regulatory factor, N-terminal part. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	745.
Open Targets More...OpenTargetsⁱ	ENSG00000124920.
PharmGKBⁱ	PA25500.

Polymorphism and mutation databases

BioMutaⁱ	MYRF.
DMDMⁱ	182637560.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
ChainⁱPRO_0000318919	1 – 1151	Myelin regulatory factorAdd BLAST	1151
ChainⁱPRO_0000424310	1 – 586	Myelin regulatory factor, N-terminal1 PublicationAdd BLAST	586
ChainⁱPRO_0000424311	587 – 1151	Myelin regulatory factor, C-terminal1 PublicationAdd BLAST	565

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	123	N6-acetyllysineCombined sources	1
Glycosylationⁱ	919	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	1043	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	1065	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	1129	N-linked (GlcNAc...) asparagineSequence analysis	1

Post-translational modificationⁱ

Myelin regulatory factor, C-terminal: Glycosylated.1 Publication

Myelin regulatory factor: Follows autocatalytic cleavage via the peptidase S74 domain. Autoprocessing is apparently constitutive and is essential for transcriptional activity.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	586 – 587	Cleavage; by autolysis1 Publication		2

Keywords - PTMⁱ

Acetylation, Autocatalytic cleavage, Glycoprotein

Proteomic databases

PaxDbⁱ	Q9Y2G1.
PeptideAtlas More...PeptideAtlasⁱ	Q9Y2G1.
PRIDEⁱ	Q9Y2G1.

PTM databases

iPTMnetⁱ	Q9Y2G1.
PhosphoSitePlusⁱ	Q9Y2G1.

Expressionⁱ

Tissue specificityⁱ

Expressed in lung, ARPE-19 cell line, brainstem, uterus and, to a lesser extent, in basal ganglion and liver. Weakly expressed in cerebellum and retina.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000124920.
CleanExⁱ	HS_C11orf9.
ExpressionAtlasⁱ	Q9Y2G1. baseline and differential.
Genevisibleⁱ	Q9Y2G1. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA018310.

HPAⁱ

HPA018310.

Interactionⁱ

Subunit structureⁱ

Homotrimer.1 Publication

Protein-protein interaction databases

Database of interacting proteins More...DIPⁱ	DIP-60483N.
STRINGⁱ	9606.ENSP00000278836.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9Y2G1.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	587 – 696	Peptidase S74Add BLAST		110

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	680 – 711	Sequence analysisAdd BLAST		32

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	254 – 257	Nuclear localization signal1 Publication		4
Motifⁱ	491 – 494	Nuclear localization signal1 Publication		4

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	77 – 330	Pro-richAdd BLAST		254

Domainⁱ

Myelin regulatory factor, N-terminal: The nuclear localization signals mediate translocation to the nucleus.1 Publication

Myelin regulatory factor: The peptidase S74 domain, also named Intramolecular Chaperone Auto-processed (ICA) domain or Intramolecuar Chaperone Domain (ICD), has protease activity and mediates autocatalytic processing of the protein to generate the Myelin regulatory factor, N-terminal active transcription factor and the Myelin regulatory factor, C-terminal components.1 Publication

Sequence similaritiesⁱ

Belongs to the MRF family.Curated

Keywords - Domainⁱ

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3661. Eukaryota. ENOG410XPRK. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063626.
HOGENOMⁱ	HOG000111718.
InParanoidⁱ	Q9Y2G1.
OMAⁱ	NIRAKSW.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0213.
PhylomeDBⁱ	Q9Y2G1.
TreeFamⁱ	TF312888.

Family and domain databases

Gene3Dⁱ	1.10.10.10. 1 hit. 2.60.40.1390. 2 hits.
InterProⁱ	View protein in InterPro IPR026933. MRF. IPR026932. MRF_C1. IPR025719. MRF_C2. IPR024061. NDT80_DNA-bd_dom. IPR008967. p53-like_TF_DNA-bd. IPR030392. S74_ICA. IPR011991. WHTH_DNA-bd_dom.
PANTHERⁱ	PTHR13029:SF20. PTHR13029:SF20. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13887. MRF_C1. 1 hit. PF13888. MRF_C2. 1 hit. PF05224. NDT80_PhoG. 1 hit. PF13884. Peptidase_S74. 1 hit.
SUPFAMⁱ	SSF49417. SSF49417. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51688. ICA. 1 hit. PS51517. NDT80. 1 hit.

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q9Y2G1-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MEVVDETEAL QRFFEGHDIN GALEPSNIDT SILEEYISKE DASDLCFPDI 
        60         70         80         90        100
SAPASSASYS HGQPAMPGSS GVHHLSPPGG GPSPGRHGPL PPPGYGTPLN 
       110        120        130        140        150
CNNNNGMGAA PKPFPGGTGP PIKAEPKAPY APGTLPDSPP DSGSEAYSPQ 
       160        170        180        190        200
QVNEPHLLRT ITPETLCHVG VPSRLEHPPP PPAHLPGPPP PPPPPPHYPV 
       210        220        230        240        250
LQRDLYMKAE PPIPHYAAMG QGLVPTDLHH TQQSQMLHQL LQQHGAELPT 
       260        270        280        290        300
HPSKKRKHSE SPPSTLNAQM LNGMIKQEPG TVTALPLHPT RAPSPPWPPQ 
       310        320        330        340        350
GPLSPGPGSL PLSIARVQTP PWHPPGAPSP GLLQDSDSLS GSYLDPNYQS 
       360        370        380        390        400
IKWQPHQQNK WATLYDANYK ELPMLTYRVD ADKGFNFSVG DDAFVCQKKN 
       410        420        430        440        450
HFQVTVYIGM LGEPKYVKTP EGLKPLDCFY LKLHGVKLEA LNQSINIEQS 
       460        470        480        490        500
QSDRSKRPFN PVTVNLPPEQ VTKVTVGRLH FSETTANNMR KKGKPNPDQR 
       510        520        530        540        550
YFMLVVALQA HAQNQNYTLA AQISERIIVR ASNPGQFESD SDVLWQRAQV 
       560        570        580        590        600
PDTVFHHGRV GINTDRPDEA LVVHGNVKVM GSLMHPSDLR AKEHVQEVDT 
       610        620        630        640        650
TEQLKRISRM RLVHYRYKPE FAASAGIEAT APETGVIAQE VKEILPEAVK 
       660        670        680        690        700
DTGDMVFANG KTIENFLVVN KERIFMENVG AVKELCKLTD NLETRIDELE 
       710        720        730        740        750
RWSHKLAKLR RLDSLKSTGS SGAFSHAGSQ FSRAGSVPHK KRPPKVASKS 
       760        770        780        790        800
SSVVPDQACI SQRFLQGTII ALVVVMAFSV VSMSTLYVLS LRTEEDLVDT 
       810        820        830        840        850
DGSFAVSTSC LLALLRPQPP GGSEALCPWS SQSFGTTQLR QSPLTTGLPG 
       860        870        880        890        900
IQPSLLLVTT SLTSSAPGSA VRTLDMCSSH PCPVICCSSP TTNPTTGPSL 
       910        920        930        940        950
GPSFNPGHVL SPSPSPSTNR SGPSQMALLP VTNIRAKSWG LSVNGIGHSK 
       960        970        980        990       1000
HHKSLEPLAS PAVPFPGGQG KAKNSPSLGF HGRARRGALQ SSVGPAEPTW 
      1010       1020       1030       1040       1050
AQGQSASLLA EPVPSLTSIQ VLENSMSITS QYCAPGDACR PGNFTYHIPV 
      1060       1070       1080       1090       1100
SSGTPLHLSL TLQMNSSSPV SVVLCSLRSK EEPCEEGSLP QSLHTHQDTQ 
      1110       1120       1130       1140       1150
GTSHRWPITI LSFREFTYHF RVALLGQANC SSEALAQPAT DYHFHFYRLC 

D

Length:1,151

Mass (Da):124,397

Last modified:February 26, 2008 - v3

Checksum:ⁱ9875DE9D72B6C50C

GO

Isoform 2 (identifier: Q9Y2G1-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: MEVVDETEALQRFFE → MHWLPA
     803-829: SFAVSTSCLLALLRPQPPGGSEALCPW → R
     1006-1010: Missing.

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        10         20         30         40         50
MHWLPAGHDI NGALEPSNID TSILEEYISK EDASDLCFPD ISAPASSASY 
        60         70         80         90        100
SHGQPAMPGS SGVHHLSPPG GGPSPGRHGP LPPPGYGTPL NCNNNNGMGA 
       110        120        130        140        150
APKPFPGGTG PPIKAEPKAP YAPGTLPDSP PDSGSEAYSP QQVNEPHLLR 
       160        170        180        190        200
TITPETLCHV GVPSRLEHPP PPPAHLPGPP PPPPPPPHYP VLQRDLYMKA 
       210        220        230        240        250
EPPIPHYAAM GQGLVPTDLH HTQQSQMLHQ LLQQHGAELP THPSKKRKHS 
       260        270        280        290        300
ESPPSTLNAQ MLNGMIKQEP GTVTALPLHP TRAPSPPWPP QGPLSPGPGS 
       310        320        330        340        350
LPLSIARVQT PPWHPPGAPS PGLLQDSDSL SGSYLDPNYQ SIKWQPHQQN 
       360        370        380        390        400
KWATLYDANY KELPMLTYRV DADKGFNFSV GDDAFVCQKK NHFQVTVYIG 
       410        420        430        440        450
MLGEPKYVKT PEGLKPLDCF YLKLHGVKLE ALNQSINIEQ SQSDRSKRPF 
       460        470        480        490        500
NPVTVNLPPE QVTKVTVGRL HFSETTANNM RKKGKPNPDQ RYFMLVVALQ 
       510        520        530        540        550
AHAQNQNYTL AAQISERIIV RASNPGQFES DSDVLWQRAQ VPDTVFHHGR 
       560        570        580        590        600
VGINTDRPDE ALVVHGNVKV MGSLMHPSDL RAKEHVQEVD TTEQLKRISR 
       610        620        630        640        650
MRLVHYRYKP EFAASAGIEA TAPETGVIAQ EVKEILPEAV KDTGDMVFAN 
       660        670        680        690        700
GKTIENFLVV NKERIFMENV GAVKELCKLT DNLETRIDEL ERWSHKLAKL 
       710        720        730        740        750
RRLDSLKSTG SSGAFSHAGS QFSRAGSVPH KKRPPKVASK SSSVVPDQAC 
       760        770        780        790        800
ISQRFLQGTI IALVVVMAFS VVSMSTLYVL SLRTEEDLVD TDGRSSQSFG 
       810        820        830        840        850
TTQLRQSPLT TGLPGIQPSL LLVTTSLTSS APGSAVRTLD MCSSHPCPVI 
       860        870        880        890        900
CCSSPTTNPT TGPSLGPSFN PGHVLSPSPS PSTNRSGPSQ MALLPVTNIR 
       910        920        930        940        950
AKSWGLSVNG IGHSKHHKSL EPLASPAVPF PGGQGKAKNS PSLGFHGRAR 
       960        970        980        990       1000
RGALQSSVGP AEPTWAQGQS EPVPSLTSIQ VLENSMSITS QYCAPGDACR 
      1010       1020       1030       1040       1050
PGNFTYHIPV SSGTPLHLSL TLQMNSSSPV SVVLCSLRSK EEPCEEGSLP 
      1060       1070       1080       1090       1100
QSLHTHQDTQ GTSHRWPITI LSFREFTYHF RVALLGQANC SSEALAQPAT 
      1110 
DYHFHFYRLC D

Note: No experimental confirmation available.

Show »

Length:1,111

Mass (Da):120,225

Checksum:ⁱ5B9CAAD3EC8C8B03

GO

Sequence cautionⁱ

The sequence BAA76798 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	478 – 484	RLHFSET → GGCIQRD in AAB92668 (PubMed:9615227).Curated	7
Sequence conflictⁱ	606	R → K in AAB92668 (PubMed:9615227).Curated	1
Sequence conflictⁱ	657 – 658	FA → LP in AAB92668 (PubMed:9615227).Curated	2

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_038907	723	A → T. Corresponds to variant dbSNP:rs34038946Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_031300	1 – 15	MEVVD…QRFFE → MHWLPA in isoform 2. 1 PublicationAdd BLAST	15
Alternative sequenceⁱVSP_031301	803 – 829	SFAVS…ALCPW → R in isoform 2. 1 PublicationAdd BLAST	27
Alternative sequenceⁱVSP_031302	1006 – 1010	Missing in isoform 2. 1 Publication	5

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF086762 mRNA. Translation: AAF28400.1. AB023171 mRNA. Translation: BAA76798.2. Different initiation. CH471076 Genomic DNA. Translation: EAW73968.1. AF038536 mRNA. Translation: AAB92668.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31579.1. [Q9Y2G1-2] CCDS44622.1. [Q9Y2G1-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001120864.1. NM_001127392.2. [Q9Y2G1-1] NP_037411.1. NM_013279.3. [Q9Y2G1-2]
UniGeneⁱ	Hs.473109.

Genome annotation databases

Ensemblⁱ	ENST00000265460; ENSP00000265460; ENSG00000124920. [Q9Y2G1-2] ENST00000278836; ENSP00000278836; ENSG00000124920. [Q9Y2G1-1]
GeneIDⁱ	745.
KEGGⁱ	hsa:745.
UCSC genome browser More...UCSCⁱ	uc001nsc.2. human. [Q9Y2G1-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q9Y2G1	UPI000789012D UPI0005F3F0ED UPI0008F53A5A UPI000387D3A8 UPI00075F88FD UPI0002746660 UPI0005F54140 UPI00076239C4 G3RRX5 UPI00071A132C +8	Homo sapiens (Human) Rousettus aegyptiacus (Egyptian rousette) (Egyptian fruit bat) Macaca nemestrina (Pig-tailed macaque) Gorilla gorilla gorilla (Western lowland gorilla) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Pan paniscus (Pygmy chimpanzee) (Bonobo) Marmota marmota marmota (Alpine marmot) Equus asinus (Donkey) (Equus africanus asinus) Manis javanica (Malayan pangolin) (Sunda pangolin) Hipposideros armiger (great roundleaf bat) And more	1,151	UniRef90_Q9Y2G1	Cluster: Myelin regulatory factor	19
Q9Y2G1-2	UPI000760AABF UPI000939E7BA UPI00080A4490 UPI000809D1A5 UPI000533D4B2 UPI00072F8796 UPI000846A80C UPI0006264650 UPI00072F9A7D UPI00080A17EA +12	Bos taurus (Bovine) Hipposideros armiger (great roundleaf bat) Cebus capucinus imitator Saimiri boliviensis boliviensis (Bolivian squirrel monkey) Ovis aries musimon (Mouflon) Capra hircus (Goat) Aotus nancymaae (Ma's night monkey) Ochotona princeps (Southern American pika) Colobus angolensis palliatus (Peters' Angolan colobus) Mandrillus leucophaeus (Drill) (Papio leucophaeus) And more	1,111	UniRef90_Q9Y2G1-2	Cluster: Isoform 2 of Myelin regulatory factor	23

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q9Y2G1	Q3UR85 UPI000B4F8ACD A0A1U8C2C8 UPI000A31FA5B UPI000B4EB96A A0A1U8BUZ2 UPI0003D72161 UPI0005AB99D8 A0A1U8C2D9 UPI000B4F3EB0 +328	Mus musculus (Mouse) Meriones unguiculatus (Mongolian jird) (Mongolian gerbil) Mesocricetus auratus (Golden hamster) Rattus norvegicus (Rat) Peromyscus maniculatus bairdii (prairie deer mouse) Microtus ochrogaster (Prairie vole) Nannospalax galili (Northern Israeli blind subterranean mole rat) (Spalax galili) Mus caroli (Ryukyu mouse) (Ricefield mouse) Columba livia (Rock dove) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) And more	1,138	UniRef50_Q3UR85	Cluster: Myelin regulatory factor	339

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF086762 mRNA. Translation: AAF28400.1. AB023171 mRNA. Translation: BAA76798.2. Different initiation. CH471076 Genomic DNA. Translation: EAW73968.1. AF038536 mRNA. Translation: AAB92668.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31579.1. [Q9Y2G1-2] CCDS44622.1. [Q9Y2G1-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001120864.1. NM_001127392.2. [Q9Y2G1-1] NP_037411.1. NM_013279.3. [Q9Y2G1-2]
UniGeneⁱ	Hs.473109.

3D structure databases

ProteinModelPortalⁱ	Q9Y2G1.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

Database of interacting proteins More...DIPⁱ	DIP-60483N.
STRINGⁱ	9606.ENSP00000278836.

PTM databases

iPTMnetⁱ	Q9Y2G1.
PhosphoSitePlusⁱ	Q9Y2G1.

Polymorphism and mutation databases

BioMutaⁱ	MYRF.
DMDMⁱ	182637560.

Proteomic databases

PaxDbⁱ	Q9Y2G1.
PeptideAtlas More...PeptideAtlasⁱ	Q9Y2G1.
PRIDEⁱ	Q9Y2G1.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	745.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000265460; ENSP00000265460; ENSG00000124920. [Q9Y2G1-2] ENST00000278836; ENSP00000278836; ENSG00000124920. [Q9Y2G1-1]
GeneIDⁱ	745.
KEGGⁱ	hsa:745.
UCSC genome browser More...UCSCⁱ	uc001nsc.2. human. [Q9Y2G1-1]

Organism-specific databases

CTDⁱ	745.
DisGeNET More...DisGeNETⁱ	745.
GeneCardsⁱ	MYRF.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1181. MYRF.
Human Protein Atlas More...HPAⁱ	HPA018310.
MIMⁱ	608329. gene.
neXtProtⁱ	NX_Q9Y2G1.
Open Targets More...OpenTargetsⁱ	ENSG00000124920.
PharmGKBⁱ	PA25500.
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3661. Eukaryota. ENOG410XPRK. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063626.
HOGENOMⁱ	HOG000111718.
InParanoidⁱ	Q9Y2G1.
OMAⁱ	NIRAKSW.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0213.
PhylomeDBⁱ	Q9Y2G1.
TreeFamⁱ	TF312888.

Miscellaneous databases

GeneWikiⁱ	Myelin_gene_Regulatory_Factor.
GenomeRNAiⁱ	745.
Protein Ontology More...PROⁱ	PR:Q9Y2G1.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000124920.
CleanExⁱ	HS_C11orf9.
ExpressionAtlasⁱ	Q9Y2G1. baseline and differential.
Genevisibleⁱ	Q9Y2G1. HS.

Family and domain databases

Gene3Dⁱ	1.10.10.10. 1 hit. 2.60.40.1390. 2 hits.
InterProⁱ	View protein in InterPro IPR026933. MRF. IPR026932. MRF_C1. IPR025719. MRF_C2. IPR024061. NDT80_DNA-bd_dom. IPR008967. p53-like_TF_DNA-bd. IPR030392. S74_ICA. IPR011991. WHTH_DNA-bd_dom.
PANTHERⁱ	PTHR13029:SF20. PTHR13029:SF20. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13887. MRF_C1. 1 hit. PF13888. MRF_C2. 1 hit. PF05224. NDT80_PhoG. 1 hit. PF13884. Peptidase_S74. 1 hit.
SUPFAMⁱ	SSF49417. SSF49417. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51688. ICA. 1 hit. PS51517. NDT80. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MYRF_HUMAN
Accessionⁱ	Q9Y2G1Primary (citable) accession number: Q9Y2G1 Secondary accession number(s): O43582, Q9P1Q6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
	Last sequence update:	February 26, 2008
	Last modified:	August 30, 2017
	This is version 113 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

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UniRef

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Supporting data

UniProtKB - Q9Y2G1 (MYRF_HUMAN)

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Myelin regulatory factor

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Sites

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequences (2)ⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ