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Q9Y2G1

- MRF_HUMAN

UniProt

Q9Y2G1 - MRF_HUMAN

Protein

Myelin regulatory factor

Gene

MYRF

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 3 (26 Feb 2008)
      Previous versions | rss
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    Functioni

    Myelin regulatory factor: Consitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates transcription of central nervous system (CNS) myelin genes (PubMed:23966832).1 Publication
    Myelin regulatory factor, C-terminal: Membrane-bound part that has no transcription factor activity and remains attached to the endoplasmic reticulum membrane following cleavage.1 Publication
    Myelin regulatory factor, N-terminal: Transcription factor that specifically activates expression of myelin genes such as MBP, MOG, MAG and PLP1 during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Specifically recognizes and binds DNA sequence 5'-CTGGYAC-3' in the regulatory regions of myelin-specific genes and directly activates their expression. Not only required during oligodendrocyte differentiation but is also required on an ongoing basis for the maintenance of expression of myelin genes and for the maintenance of a mature, viable oligodendrocyte phenotype (PubMed:23966832).1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei586 – 5872Cleavage; by autocatalysis

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi250 – 541292NDT80PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. peptidase activity Source: UniProtKB-KW
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. central nervous system myelination Source: UniProtKB
    2. central nervous system myelin maintenance Source: UniProtKB
    3. oligodendrocyte development Source: UniProtKB
    4. oligodendrocyte differentiation Source: UniProtKB
    5. positive regulation of myelination Source: UniProtKB
    6. positive regulation of transcription, DNA-templated Source: UniProtKB
    7. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Hydrolase, Protease

    Keywords - Biological processi

    Differentiation, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myelin regulatory factor (EC:3.4.-.-)
    Alternative name(s):
    Myelin gene regulatory factor
    Cleaved into the following 2 chains:
    Gene namesi
    Name:MYRF
    Synonyms:C11orf9, KIAA0954, MRF
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:1181. MYRF.

    Subcellular locationi

    Chain Myelin regulatory factor, N-terminal : Nucleus. Cytoplasm
    Note: Translocates from the cytoplasm to the nucleus upon autocatalytic cleavage.

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Endoplasmic reticulum, Membrane, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi587 – 5871S → A: Prevents autocatalytic cleavage and generation of Myelin regulatory factor, N-terminal part. 1 Publication
    Mutagenesisi588 – 5881D → A: Reduces autocatalytic cleavage and generation of Myelin regulatory factor, N-terminal part. 1 Publication
    Mutagenesisi592 – 5921K → A: Prevents autocatalytic cleavage and generation of Myelin regulatory factor, N-terminal part. 1 Publication
    Mutagenesisi608 – 6081S → A: Does not affect autocatalytic cleavage. 1 Publication
    Mutagenesisi635 – 6351G → A: Reduces autocatalytic cleavage and generation of Myelin regulatory factor, N-terminal part. 1 Publication
    Mutagenesisi688 – 6881L → A: Does not affect autocatalytic cleavage. 1 Publication
    Mutagenesisi699 – 6991L → A: Prevents autocatalytic cleavage and generation of Myelin regulatory factor, N-terminal part. 1 Publication

    Organism-specific databases

    PharmGKBiPA25500.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11511151Myelin regulatory factorPRO_0000318919Add
    BLAST
    Chaini1 – 586586Myelin regulatory factor, N-terminalPRO_0000424310Add
    BLAST
    Chaini587 – 1151565Myelin regulatory factor, C-terminalPRO_0000424311Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei123 – 1231N6-acetyllysine1 Publication
    Glycosylationi919 – 9191N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1043 – 10431N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1065 – 10651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1129 – 11291N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Myelin regulatory factor, C-terminal: Glycosylated.1 Publication
    Myelin regulatory factor: Follows autocatalytic cleavage via the peptidase S74 domain. Autoprocessing is apparently constitutive and is essential for transcriptional activity (PubMed:23966832).1 Publication

    Keywords - PTMi

    Acetylation, Autocatalytic cleavage, Glycoprotein

    Proteomic databases

    MaxQBiQ9Y2G1.
    PaxDbiQ9Y2G1.
    PRIDEiQ9Y2G1.

    PTM databases

    PhosphoSiteiQ9Y2G1.

    Expressioni

    Tissue specificityi

    Expressed in lung, ARPE-19 cell line, brainstem, uterus and, to a lesser extent, in basal ganglion and liver. Weakly expressed in cerebellum and retina.1 Publication

    Gene expression databases

    ArrayExpressiQ9Y2G1.
    BgeeiQ9Y2G1.
    CleanExiHS_C11orf9.
    GenevestigatoriQ9Y2G1.

    Organism-specific databases

    HPAiHPA018310.

    Interactioni

    Subunit structurei

    Homotrimer.1 Publication

    Protein-protein interaction databases

    BioGridi107203. 1 interaction.
    DIPiDIP-60483N.
    STRINGi9606.ENSP00000278836.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y2G1.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 768768CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini790 – 1151362LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei769 – 78921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini587 – 696110Peptidase S74Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili680 – 71132Sequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi254 – 2574Nuclear localization signal
    Motifi491 – 4944Nuclear localization signal

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi77 – 330254Pro-richAdd
    BLAST

    Domaini

    Myelin regulatory factor, N-terminal: The nuclear localization signals mediate translocation to the nucleus.1 Publication
    Myelin regulatory factor: The peptidase S74 domain, also named Intramolecular Chaperone Auto-processed (ICA) domain or Intramolecuar Chaperone Domain (ICD), has protease activity and mediates autocatalytic processing of the protein to generate the Myelin regulatory factor, N-terminal active transcription factor and the Myelin regulatory factor, C-terminal components.1 Publication

    Sequence similaritiesi

    Belongs to the MRF family.Curated
    Contains 1 NDT80 DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 peptidase S74 domain.Curated

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG253930.
    HOGENOMiHOG000111718.
    InParanoidiQ9Y2G1.
    OMAiCPVVCCS.
    OrthoDBiEOG77M8N4.
    PhylomeDBiQ9Y2G1.
    TreeFamiTF312888.

    Family and domain databases

    Gene3Di2.60.40.1390. 1 hit.
    InterProiIPR026933. MRF.
    IPR026932. MRF_C1.
    IPR025719. MRF_C2.
    IPR024061. NDT80_DNA-bd_dom.
    IPR008967. p53-like_TF_DNA-bd.
    [Graphical view]
    PANTHERiPTHR13029:SF16. PTHR13029:SF16. 1 hit.
    PfamiPF13887. MRF_C1. 1 hit.
    PF13888. MRF_C2. 1 hit.
    PF05224. NDT80_PhoG. 1 hit.
    [Graphical view]
    SUPFAMiSSF49417. SSF49417. 1 hit.
    PROSITEiPS51688. ICA. 1 hit.
    PS51517. NDT80. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y2G1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEVVDETEAL QRFFEGHDIN GALEPSNIDT SILEEYISKE DASDLCFPDI     50
    SAPASSASYS HGQPAMPGSS GVHHLSPPGG GPSPGRHGPL PPPGYGTPLN 100
    CNNNNGMGAA PKPFPGGTGP PIKAEPKAPY APGTLPDSPP DSGSEAYSPQ 150
    QVNEPHLLRT ITPETLCHVG VPSRLEHPPP PPAHLPGPPP PPPPPPHYPV 200
    LQRDLYMKAE PPIPHYAAMG QGLVPTDLHH TQQSQMLHQL LQQHGAELPT 250
    HPSKKRKHSE SPPSTLNAQM LNGMIKQEPG TVTALPLHPT RAPSPPWPPQ 300
    GPLSPGPGSL PLSIARVQTP PWHPPGAPSP GLLQDSDSLS GSYLDPNYQS 350
    IKWQPHQQNK WATLYDANYK ELPMLTYRVD ADKGFNFSVG DDAFVCQKKN 400
    HFQVTVYIGM LGEPKYVKTP EGLKPLDCFY LKLHGVKLEA LNQSINIEQS 450
    QSDRSKRPFN PVTVNLPPEQ VTKVTVGRLH FSETTANNMR KKGKPNPDQR 500
    YFMLVVALQA HAQNQNYTLA AQISERIIVR ASNPGQFESD SDVLWQRAQV 550
    PDTVFHHGRV GINTDRPDEA LVVHGNVKVM GSLMHPSDLR AKEHVQEVDT 600
    TEQLKRISRM RLVHYRYKPE FAASAGIEAT APETGVIAQE VKEILPEAVK 650
    DTGDMVFANG KTIENFLVVN KERIFMENVG AVKELCKLTD NLETRIDELE 700
    RWSHKLAKLR RLDSLKSTGS SGAFSHAGSQ FSRAGSVPHK KRPPKVASKS 750
    SSVVPDQACI SQRFLQGTII ALVVVMAFSV VSMSTLYVLS LRTEEDLVDT 800
    DGSFAVSTSC LLALLRPQPP GGSEALCPWS SQSFGTTQLR QSPLTTGLPG 850
    IQPSLLLVTT SLTSSAPGSA VRTLDMCSSH PCPVICCSSP TTNPTTGPSL 900
    GPSFNPGHVL SPSPSPSTNR SGPSQMALLP VTNIRAKSWG LSVNGIGHSK 950
    HHKSLEPLAS PAVPFPGGQG KAKNSPSLGF HGRARRGALQ SSVGPAEPTW 1000
    AQGQSASLLA EPVPSLTSIQ VLENSMSITS QYCAPGDACR PGNFTYHIPV 1050
    SSGTPLHLSL TLQMNSSSPV SVVLCSLRSK EEPCEEGSLP QSLHTHQDTQ 1100
    GTSHRWPITI LSFREFTYHF RVALLGQANC SSEALAQPAT DYHFHFYRLC 1150
    D 1151
    Length:1,151
    Mass (Da):124,397
    Last modified:February 26, 2008 - v3
    Checksum:i9875DE9D72B6C50C
    GO
    Isoform 2 (identifier: Q9Y2G1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-15: MEVVDETEALQRFFE → MHWLPA
         803-829: SFAVSTSCLLALLRPQPPGGSEALCPW → R
         1006-1010: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,111
    Mass (Da):120,225
    Checksum:i5B9CAAD3EC8C8B03
    GO

    Sequence cautioni

    The sequence BAA76798.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti478 – 4847RLHFSET → GGCIQRD in AAB92668. (PubMed:9615227)Curated
    Sequence conflicti606 – 6061R → K in AAB92668. (PubMed:9615227)Curated
    Sequence conflicti657 – 6582FA → LP in AAB92668. (PubMed:9615227)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti723 – 7231A → T.
    Corresponds to variant rs34038946 [ dbSNP | Ensembl ].
    VAR_038907

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1515MEVVD…QRFFE → MHWLPA in isoform 2. 1 PublicationVSP_031300Add
    BLAST
    Alternative sequencei803 – 82927SFAVS…ALCPW → R in isoform 2. 1 PublicationVSP_031301Add
    BLAST
    Alternative sequencei1006 – 10105Missing in isoform 2. 1 PublicationVSP_031302

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF086762 mRNA. Translation: AAF28400.1.
    AB023171 mRNA. Translation: BAA76798.2. Different initiation.
    CH471076 Genomic DNA. Translation: EAW73968.1.
    AF038536 mRNA. Translation: AAB92668.1.
    CCDSiCCDS31579.1. [Q9Y2G1-2]
    CCDS44622.1. [Q9Y2G1-1]
    RefSeqiNP_001120864.1. NM_001127392.1. [Q9Y2G1-1]
    NP_037411.1. NM_013279.2. [Q9Y2G1-2]
    UniGeneiHs.473109.

    Genome annotation databases

    EnsembliENST00000265460; ENSP00000265460; ENSG00000124920. [Q9Y2G1-2]
    ENST00000278836; ENSP00000278836; ENSG00000124920. [Q9Y2G1-1]
    GeneIDi745.
    KEGGihsa:745.
    UCSCiuc001nsc.1. human. [Q9Y2G1-1]
    uc001nse.1. human. [Q9Y2G1-2]

    Polymorphism databases

    DMDMi182637560.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF086762 mRNA. Translation: AAF28400.1 .
    AB023171 mRNA. Translation: BAA76798.2 . Different initiation.
    CH471076 Genomic DNA. Translation: EAW73968.1 .
    AF038536 mRNA. Translation: AAB92668.1 .
    CCDSi CCDS31579.1. [Q9Y2G1-2 ]
    CCDS44622.1. [Q9Y2G1-1 ]
    RefSeqi NP_001120864.1. NM_001127392.1. [Q9Y2G1-1 ]
    NP_037411.1. NM_013279.2. [Q9Y2G1-2 ]
    UniGenei Hs.473109.

    3D structure databases

    ProteinModelPortali Q9Y2G1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107203. 1 interaction.
    DIPi DIP-60483N.
    STRINGi 9606.ENSP00000278836.

    PTM databases

    PhosphoSitei Q9Y2G1.

    Polymorphism databases

    DMDMi 182637560.

    Proteomic databases

    MaxQBi Q9Y2G1.
    PaxDbi Q9Y2G1.
    PRIDEi Q9Y2G1.

    Protocols and materials databases

    DNASUi 745.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000265460 ; ENSP00000265460 ; ENSG00000124920 . [Q9Y2G1-2 ]
    ENST00000278836 ; ENSP00000278836 ; ENSG00000124920 . [Q9Y2G1-1 ]
    GeneIDi 745.
    KEGGi hsa:745.
    UCSCi uc001nsc.1. human. [Q9Y2G1-1 ]
    uc001nse.1. human. [Q9Y2G1-2 ]

    Organism-specific databases

    CTDi 745.
    GeneCardsi GC11P061521.
    HGNCi HGNC:1181. MYRF.
    HPAi HPA018310.
    MIMi 608329. gene.
    neXtProti NX_Q9Y2G1.
    PharmGKBi PA25500.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG253930.
    HOGENOMi HOG000111718.
    InParanoidi Q9Y2G1.
    OMAi CPVVCCS.
    OrthoDBi EOG77M8N4.
    PhylomeDBi Q9Y2G1.
    TreeFami TF312888.

    Miscellaneous databases

    ChiTaRSi C11orf9. human.
    GeneWikii Myelin_gene_Regulatory_Factor.
    GenomeRNAii 745.
    NextBioi 3016.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y2G1.
    Bgeei Q9Y2G1.
    CleanExi HS_C11orf9.
    Genevestigatori Q9Y2G1.

    Family and domain databases

    Gene3Di 2.60.40.1390. 1 hit.
    InterProi IPR026933. MRF.
    IPR026932. MRF_C1.
    IPR025719. MRF_C2.
    IPR024061. NDT80_DNA-bd_dom.
    IPR008967. p53-like_TF_DNA-bd.
    [Graphical view ]
    PANTHERi PTHR13029:SF16. PTHR13029:SF16. 1 hit.
    Pfami PF13887. MRF_C1. 1 hit.
    PF13888. MRF_C2. 1 hit.
    PF05224. NDT80_PhoG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49417. SSF49417. 1 hit.
    PROSITEi PS51688. ICA. 1 hit.
    PS51517. NDT80. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning and genomic structure of a novel gene (C11orf9) localized to chromosome 11q12-->q13.1 which encodes a highly conserved, potential membrane-associated protein."
      Stoehr H., Marquardt A., White K., Weber B.H.F.
      Cytogenet. Cell Genet. 88:211-216(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
    2. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "Transcript mapping of the human chromosome 11q12-q13.1 gene-rich region identifies several newly described conserved genes."
      Cooper P.R., Nowak N.J., Higgins M.J., Church D.M., Shows T.B.
      Genomics 49:419-429(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 476-660.
    6. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-123, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "A bacteriophage tailspike domain promotes self-cleavage of a human membrane-bound transcription factor, the myelin regulatory factor MYRF."
      Li Z., Park Y., Marcotte E.M.
      PLoS Biol. 11:E1001624-E1001624(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, SUBUNIT, PROTEOLYTIC PROCESSING, GLYCOSYLATION, AUTOCATALYTIC CLEAVAGE, TOPOLOGY, MUTAGENESIS OF SER-587; ASP-588; LYS-592; SER-608; GLY-635; LEU-688 AND LEU-699, FUNCTION, DOMAIN.

    Entry informationi

    Entry nameiMRF_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y2G1
    Secondary accession number(s): O43582, Q9P1Q6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: February 26, 2008
    Last modified: October 1, 2014
    This is version 91 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Peptidase families
      Classification of peptidase families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3