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Protein

Protein EFR3 homolog B

Gene

EFR3B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:23229899, PubMed:25608530, PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns4P) synthesis (Probable). In the complex, EFR3B probably acts as the membrane-anchoring component (PubMed:23229899). Also involved in responsiveness to G-protein-coupled receptors; it is however unclear whether this role is direct or indirect (PubMed:25380825).Curated4 Publications

GO - Biological processi

  • establishment of protein localization to plasma membrane Source: UniProtKB
  • phosphatidylinositol phosphorylation Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000084710-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein EFR3 homolog BCurated
Gene namesi
Name:EFR3BImported
Synonyms:KIAA09531 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:29155. EFR3B.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: UniProtKB-SubCell
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi5 – 8CGCC → SGSS: Induces localization to the cytosol. 2 Publications4

Organism-specific databases

DisGeNETi22979.
OpenTargetsiENSG00000084710.
PharmGKBiPA162384473.

Polymorphism and mutation databases

BioMutaiEFR3B.
DMDMi162416214.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003122951 – 817Protein EFR3 homolog BAdd BLAST817

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei212PhosphoserineBy similarity1
Modified residuei214PhosphoserineBy similarity1
Modified residuei216PhosphoserineBy similarity1

Post-translational modificationi

Palmitoylated at its N-terminus, anchoring the protein to the plasma membrane.2 Publications

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

EPDiQ9Y2G0.
PaxDbiQ9Y2G0.
PeptideAtlasiQ9Y2G0.
PRIDEiQ9Y2G0.

PTM databases

iPTMnetiQ9Y2G0.
PhosphoSitePlusiQ9Y2G0.

Expressioni

Gene expression databases

BgeeiENSG00000084710.
CleanExiHS_EFR3B.
ExpressionAtlasiQ9Y2G0. baseline and differential.
GenevisibleiQ9Y2G0. HS.

Organism-specific databases

HPAiHPA038088.
HPA038089.

Interactioni

Subunit structurei

Component of a phosphatidylinositol 4-kinase (PI4K) complex, composed of PI4KA, EFR3 (EFR3A or EFR3B), TTC7 (TTC7A or TTC7B) and FAM126 (FAM126A or FAM126B).3 Publications

Protein-protein interaction databases

BioGridi116628. 8 interactors.
IntActiQ9Y2G0. 1 interactor.
STRINGi9606.ENSP00000384081.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2G0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the EFR3 family.Curated

Phylogenomic databases

eggNOGiKOG1877. Eukaryota.
ENOG410YJSK. LUCA.
GeneTreeiENSGT00390000002143.
HOGENOMiHOG000007148.
HOVERGENiHBG060233.
InParanoidiQ9Y2G0.
OMAiVDSVGME.
OrthoDBiEOG091G01LS.
PhylomeDBiQ9Y2G0.
TreeFamiTF314098.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y2G0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYGVCGCCGA LRPRYKRLVD NIFPEDPEDG LVKTNMEKLT FYALSAPEKL
60 70 80 90 100
DRIGAYLSER LIRDVGRHRY GYVCIAMEAL DQLLMACHCQ SINLFVESFL
110 120 130 140 150
KMVAKLLESE KPNLQILGTN SFVKFANIEE DTPSYHRSYD FFVSRFSEMC
160 170 180 190 200
HSSHDDLEIK TKIRMSGIKG LQGVVRKTVN DELQANIWDP QHMDKIVPSL
210 220 230 240 250
LFNLQHVEEA ESRSPSPLQA PEKEKESPAE LAERCLRELL GRAAFGNIKN
260 270 280 290 300
AIKPVLIHLD NHSLWEPKVF AIRCFKIIMY SIQPQHSHLV IQQLLGHLDA
310 320 330 340 350
NSRSAATVRA GIVEVLSEAA VIAATGSVGP TVLEMFNTLL RQLRLSIDYA
360 370 380 390 400
LTGSYDGAVS LGTKIIKEHE ERMFQEAVIK TVGSFASTLP TYQRSEVILF
410 420 430 440 450
IMSKVPRPSL HQAVDTGRTG ENRNRLTQIM LLKSLLQVST GFQCNNMMSA
460 470 480 490 500
LPSNFLDRLL STALMEDAEI RLFVLEILIS FIDRHGNRHK FSTISTLSDI
510 520 530 540 550
SVLKLKVDKC SRQDTVFMKK HSQQLYRHIY LSCKEETNVQ KHYEALYGLL
560 570 580 590 600
ALISIELANE EVVVDLIRLV LAVQDVAQVN EENLPVYNRC ALYALGAAYL
610 620 630 640 650
NLISQLTTVP AFCQHIHEVI ETRKKEAPYM LPEDVFVERP RLSQNLDGVV
660 670 680 690 700
IELLFRQSKI SEVLGGSGYN SDRLCLPYIP QLTDEDRLSK RRSIGETISL
710 720 730 740 750
QVEVESRNSP EKEERVPAEE ITYETLKKAI VDSVAVEEQE RERRRQVVEK
760 770 780 790 800
FQKAPFEEIA AHCGARASLL QSKLNQIFEI TIRPPPSPSG TITAAYGQPQ
810
NHSIPVYEMK FPDLCVY
Length:817
Mass (Da):92,487
Last modified:December 4, 2007 - v2
Checksum:i30F4AB3C957AAEE6
GO
Isoform 2 (identifier: Q9Y2G0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-148: Missing.

Show »
Length:669
Mass (Da):75,482
Checksum:i95B936F46F5C9E65
GO
Isoform 3 (identifier: Q9Y2G0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     715-817: RVPAEEITYE...EMKFPDLCVY → VSVRATVLGQPHLL

Show »
Length:728
Mass (Da):82,290
Checksum:i6E63E91C795ED6B9
GO

Sequence cautioni

The sequence BAA76797 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0298061 – 148Missing in isoform 2. 1 PublicationAdd BLAST148
Alternative sequenceiVSP_029807715 – 817RVPAE…DLCVY → VSVRATVLGQPHLL in isoform 3. 1 PublicationAdd BLAST103

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023170 mRNA. Translation: BAA76797.1. Different initiation.
AC012457 Genomic DNA. Translation: AAY24353.1.
AC013267 Genomic DNA. No translation available.
CH471053 Genomic DNA. Translation: EAX00733.1.
BC049384 mRNA. Translation: AAH49384.1.
CCDSiCCDS46231.1. [Q9Y2G0-1]
RefSeqiNP_055786.1. NM_014971.1. [Q9Y2G0-1]
UniGeneiHs.4892.

Genome annotation databases

EnsembliENST00000401432; ENSP00000386082; ENSG00000084710. [Q9Y2G0-3]
ENST00000403714; ENSP00000384081; ENSG00000084710. [Q9Y2G0-1]
ENST00000405108; ENSP00000384454; ENSG00000084710. [Q9Y2G0-2]
GeneIDi22979.
KEGGihsa:22979.
UCSCiuc002rfw.3. human. [Q9Y2G0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023170 mRNA. Translation: BAA76797.1. Different initiation.
AC012457 Genomic DNA. Translation: AAY24353.1.
AC013267 Genomic DNA. No translation available.
CH471053 Genomic DNA. Translation: EAX00733.1.
BC049384 mRNA. Translation: AAH49384.1.
CCDSiCCDS46231.1. [Q9Y2G0-1]
RefSeqiNP_055786.1. NM_014971.1. [Q9Y2G0-1]
UniGeneiHs.4892.

3D structure databases

ProteinModelPortaliQ9Y2G0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116628. 8 interactors.
IntActiQ9Y2G0. 1 interactor.
STRINGi9606.ENSP00000384081.

PTM databases

iPTMnetiQ9Y2G0.
PhosphoSitePlusiQ9Y2G0.

Polymorphism and mutation databases

BioMutaiEFR3B.
DMDMi162416214.

Proteomic databases

EPDiQ9Y2G0.
PaxDbiQ9Y2G0.
PeptideAtlasiQ9Y2G0.
PRIDEiQ9Y2G0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000401432; ENSP00000386082; ENSG00000084710. [Q9Y2G0-3]
ENST00000403714; ENSP00000384081; ENSG00000084710. [Q9Y2G0-1]
ENST00000405108; ENSP00000384454; ENSG00000084710. [Q9Y2G0-2]
GeneIDi22979.
KEGGihsa:22979.
UCSCiuc002rfw.3. human. [Q9Y2G0-1]

Organism-specific databases

CTDi22979.
DisGeNETi22979.
GeneCardsiEFR3B.
H-InvDBHIX0001882.
HGNCiHGNC:29155. EFR3B.
HPAiHPA038088.
HPA038089.
neXtProtiNX_Q9Y2G0.
OpenTargetsiENSG00000084710.
PharmGKBiPA162384473.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1877. Eukaryota.
ENOG410YJSK. LUCA.
GeneTreeiENSGT00390000002143.
HOGENOMiHOG000007148.
HOVERGENiHBG060233.
InParanoidiQ9Y2G0.
OMAiVDSVGME.
OrthoDBiEOG091G01LS.
PhylomeDBiQ9Y2G0.
TreeFamiTF314098.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000084710-MONOMER.

Miscellaneous databases

ChiTaRSiEFR3B. human.
GenomeRNAii22979.
PROiQ9Y2G0.

Gene expression databases

BgeeiENSG00000084710.
CleanExiHS_EFR3B.
ExpressionAtlasiQ9Y2G0. baseline and differential.
GenevisibleiQ9Y2G0. HS.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiEFR3B_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2G0
Secondary accession number(s): B7WPL8, Q86XU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: November 2, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.