Reviewed, UniProtKB/Swiss-Prot Q9Y2F9 (BTBD3_HUMAN)

Names and origin

Protein names

Recommended name:
    BTB/POZ domain-containing protein 3

Gene names

Name:	BTBD3
Synonyms:	KIAA0952

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	522 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Contains 1 BTB (POZ) domain.

Ontologies

Keywords
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 522	522	BTB/POZ domain-containing protein 3		PRO_0000186211
Regions
	Domain	120 – 190	71	BTB
	Compositional bias	36 – 43	8	Poly-Ser

Sequences

	Sequence		Length	Mass (Da)
	Q9Y2F9-1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: A5E1359C96FF8919	FASTA	522	58,420
	10 20 30 40 50 60 MVDDKEKNMK CLTFFLMLPE TVKNRSKKSS KKANTSSSSS NSSKLPPVCY EIITLKTKKK 70 80 90 100 110 120 KMAADIFPRK KPANSSSTSV QQYHQQNLSN NNLIPAPNWQ GLYPTIRERN AMMFNNDLMA 130 140 150 160 170 180 DVHFVVGPPG GTQRLPGHKY VLAVGSSVFH AMFYGELAED KDEIRIPDVE PAAFLAMLKY 190 200 210 220 230 240 IYCDEIDLAA DTVLATLYAA KKYIVPHLAR ACVNFLETSL SAKNACVLLS QSCLFEEPDL 250 260 270 280 290 300 TQRCWEVIDA QAELALKSEG FCDIDFQTLE SILRRETLNA KEIVVFEAAL NWAEVECQRQ 310 320 330 340 350 360 DLALSIENKR KVLGKALYLI RIPTMALDDF ANGAAQSGVL TLNETNDIFL WYTAAKKPEL 370 380 390 400 410 420 QFVSKARKGL VPQRCHRFQS CAYRSNQWRY RGRCDSIQFA VDKRVFIAGF GLYGSSCGSA 430 440 450 460 470 480 EYSAKIELKR QGVVLGQNLS KYFSDGSSNT FPVWFEYPVQ IEPDTFYTAS VILDGNELSY 490 500 510 520 FGQEGMTEVQ CGKVTVQFQC SSDSTNGTGV QGGQIPELIF YA

References

[1]

"Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 6:63-70(1999) [PubMed: 10231032] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.

[2]

"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB023169 mRNA. Translation: BAA76796.2. Different initiation. AL035448 Genomic DNA. Translation: CAC22147.1.
IPI	IPI00941669.
RefSeq	NP_055777.1. NP_852108.1.
UniGene	Hs.709366
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y2F9. 1 interaction.
STRING	Q9Y2F9.
Proteomic databases
PRIDE	Q9Y2F9.
Genome annotation databases
Ensembl	ENST00000378226; ENSP00000367471; ENSG00000132640; Homo sapiens. [Genome view] ENST00000405977; ENSP00000384545; ENSG00000132640; Homo sapiens. [Genome view]
GeneID	22903.
KEGG	hsa:22903.
UCSC	uc002wnz.1. human.
Organism-specific databases
CTD	22903.
GeneCards	GC20P011866.
H-InvDB	HIX0015644. HIX0040686.
HGNC	HGNC:15854. BTBD3.
PharmGKB	PA25440.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q9Y2F9.
InParanoid	Q9Y2F9.
Gene expression databases
ArrayExpress	Q9Y2F9.
Bgee	Q9Y2F9.
CleanEx	HS_BTBD3.
Genevestigator	Q9Y2F9.
GermOnline	ENSG00000132640. Homo sapiens.
Family and domain databases
InterPro	IPR011705. BACK. IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR013069. BTB_POZ. IPR013089. Kelch_related. IPR012983. PHR. [Graphical view]
Gene3D	G3DSA:3.30.710.10. BTB/POZ_fold. 1 hit.
PANTHER	PTHR23230. Kelch_related. 1 hit.
Pfam	PF00651. BTB. 1 hit. PF08005. PHR. 1 hit. [Graphical view]
SMART	SM00875. BACK. 1 hit. SM00225. BTB. 1 hit. [Graphical view]
PROSITE	PS50097. BTB. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	43545.

Entry information

Entry name

BTBD3_HUMAN

Accession

Primary (citable) accession number: Q9Y2F9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	November 1, 1999
Last modified:	December 15, 2009
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.