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Protein

Little elongation complex subunit 1

Gene

ICE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780).2 Publications

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

  • positive regulation of intracellular protein transport Source: UniProtKB
  • positive regulation of protein complex assembly Source: UniProtKB
  • positive regulation of transcription from RNA polymerase III promoter Source: UniProtKB
  • snRNA transcription from RNA polymerase III promoter Source: UniProtKB
  • snRNA transcription from RNA polymerase II promoter Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-6807505. RNA polymerase II transcribes snRNA genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Little elongation complex subunit 1
Alternative name(s):
Interactor of little elongator complex ELL subunit 1
Gene namesi
Name:ICE1
Synonyms:KIAA0947
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:29154. ICE1.

Subcellular locationi

GO - Cellular componenti

  • Cajal body Source: UniProtKB
  • histone locus body Source: UniProtKB
  • nucleoplasm Source: Reactome
  • transcriptionally active chromatin Source: UniProtKB
  • transcription elongation factor complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162411094.

Polymorphism and mutation databases

BioMutaiKIAA0947.
DMDMi296439500.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 22662266Little elongation complex subunit 1PRO_0000295724Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei255 – 2551PhosphoserineCombined sources
Modified residuei533 – 5331PhosphoserineCombined sources
Modified residuei558 – 5581PhosphoserineCombined sources
Modified residuei589 – 5891PhosphoserineCombined sources
Modified residuei707 – 7071PhosphoserineBy similarity
Modified residuei832 – 8321PhosphothreonineCombined sources
Modified residuei925 – 9251PhosphoserineCombined sources
Modified residuei958 – 9581PhosphoserineCombined sources
Modified residuei1218 – 12181N6-acetyllysineCombined sources
Modified residuei1588 – 15881PhosphoserineCombined sources
Modified residuei1617 – 16171PhosphoserineBy similarity
Modified residuei1642 – 16421PhosphothreonineCombined sources
Modified residuei1692 – 16921PhosphoserineCombined sources
Modified residuei1697 – 16971PhosphoserineCombined sources
Modified residuei1699 – 16991PhosphoserineCombined sources
Modified residuei1701 – 17011PhosphoserineCombined sources
Modified residuei1712 – 17121PhosphoserineCombined sources
Modified residuei1838 – 18381PhosphoserineCombined sources
Modified residuei1854 – 18541PhosphoserineCombined sources
Modified residuei1903 – 19031PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9Y2F5.
MaxQBiQ9Y2F5.
PaxDbiQ9Y2F5.
PeptideAtlasiQ9Y2F5.
PRIDEiQ9Y2F5.

PTM databases

iPTMnetiQ9Y2F5.
PhosphoSiteiQ9Y2F5.

Expressioni

Gene expression databases

BgeeiENSG00000164151.
ExpressionAtlasiQ9Y2F5. baseline and differential.
GenevisibleiQ9Y2F5. HS.

Organism-specific databases

HPAiHPA054452.
HPA061934.

Interactioni

Subunit structurei

Component of the little elongation complex (LEC), at least composed of ELL (ELL, ELL2 or ELL3), ZC3H8, ICE1 and ICE2. Interacts (via N-terminus domain) with ELL. Interacts (via C-terminus domain) with ICE2 and ZC3H8.2 Publications

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi116955. 20 interactions.
IntActiQ9Y2F5. 17 interactions.
MINTiMINT-8247375.
STRINGi9606.ENSP00000296564.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2F5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili23 – 186164Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi340 – 36728Pro-richAdd
BLAST
Compositional biasi1630 – 1733104Pro-richAdd
BLAST

Domaini

The N-termimus domain is necessary and sufficient for its targeting to subnuclear cajal and histone locus bodies.1 Publication

Sequence similaritiesi

Belongs to the ICE1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IE47. Eukaryota.
ENOG4111F6B. LUCA.
GeneTreeiENSGT00530000064287.
HOGENOMiHOG000168419.
HOVERGENiHBG108025.
InParanoidiQ9Y2F5.
OMAiLFIANMW.
OrthoDBiEOG091G00AF.
PhylomeDBiQ9Y2F5.
TreeFamiTF330760.

Sequencei

Sequence statusi: Complete.

Q9Y2F5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMPGETHSAA PGTAADLSRC QGCASLQQNL NEYVEALITL KQKIINTDNL
60 70 80 90 100
LTEYQKKCDE LQFARRENSN LHHQVEEMLQ KISPLQKCQE ELGSLKAELE
110 120 130 140 150
EKKSSLKLYQ DTHQEYARVK EECLKSDAQK KKLEAKVKKL QEAAVKQTQD
160 170 180 190 200
FKQLRNEKKI LEKEFKKTQE RLDEFSKQKN EKELRHIGTQ ISSDSYGSID
210 220 230 240 250
KRKVKLLLKE LWLCVNTTHR LPGEGSRCVP EKPAKAITSS RVPGEDGTLP
260 270 280 290 300
PTQGSPLRTS NVQTCLTKLS MEIKEDFLCQ NVEKQSSSGT NCSSDHVFNE
310 320 330 340 350
NGNLEVLVQS HRDGGSTEFV DHDHFFDEDL QAAIDFFKLP PPLLSPVPSP
360 370 380 390 400
PPMSSPHPGS LPSSFAPETY FGEYTDSSDN DSVQLRNSAE CVSEDDTTES
410 420 430 440 450
QNYFGSLRKN KGSGTWEEKP KSHEAIQALN TWEVNKVTTS GLETFTATLR
460 470 480 490 500
ESSATHSLVG EKHWTTASRS MSDRKRDILH ETKTQMEVRE MDKSVQTEKT
510 520 530 540 550
IHKLTRGLCI ERLSASPAQE KEAAPGKSEL CSSPLGKRPL NELMESEGKT
560 570 580 590 600
VLSKMMGSPK SEFTKWTRIN EITSEPDRIT VSGHFHRLSR ELEKEKEDTQ
610 620 630 640 650
GFTLGESPES EDDDSGDGMD VAGLDIETSF SSSSTLVALS VGSNPQSSSG
660 670 680 690 700
LDCGNDTDIT TKVFSTEPHH SEHKLQTKTL NTLHLQSEPP ECSIGGNNLE
710 720 730 740 750
NSLCALSPEL GASNFNDQKS SGIEYTKVVK GLTKIHSLPR SVFMKATKDG
760 770 780 790 800
QCESQDPRIE LTLNKPDFTS LIGSQAALIK SGLGFVKSTS WHHSDLLRKG
810 820 830 840 850
GEESLRAKSE HEQKTSHQLQ KAMPFLQNRG PTPKPDLLRE NNNPVEFKTT
860 870 880 890 900
ASVLPNQVSV ITKQTRPEKV QSAKLEHLRP HRVEPTLVTE NSGNKTGMST
910 920 930 940 950
VAKCDGERDD TTQNITEVAA VKSISPEVSA SRRKLDFNSP GGSSPVENSD
960 970 980 990 1000
CSTNSRLSFS PENILIQNQD IVREAAVQGD GQKQRQPQAT DLDSSGTHGS
1010 1020 1030 1040 1050
EMLPATEVTV SGGFSVEETS CGDTGRSGGE ALAVANDSTS TPQNANGLWK
1060 1070 1080 1090 1100
LKSTTPGGAL PECFGTTDTT FSSAFCRKHG ETQDTSQSSL PGTLHCYTGI
1110 1120 1130 1140 1150
REGGDDTEVE SEAFSCSEGS EQQDAPDDSQ KNLGDTDAAV AEVRPSLEVG
1160 1170 1180 1190 1200
YLTSALQDFN ISTFSELDRL STSEVVMFLE SCQLGDYSSG DSVSECSSKG
1210 1220 1230 1240 1250
TLSKEMNKEL KASEIGEKYR KQPCEEETLG TCEEWIESEE DDYSLKNTSQ
1260 1270 1280 1290 1300
LTQCSLETLS EVLTKIRQEL QTNSEDCNGK DTGSLLLLNV NNNMTTENLK
1310 1320 1330 1340 1350
EKSPFRETTG SSSHASEPTP QAAALDTEGS SPISGMPQNE NPQSRPEARS
1360 1370 1380 1390 1400
DAGRQTDGGE EDLPEPVEPS ALCSDSVMEP SIEQSSNCEA ETTFQCQIAT
1410 1420 1430 1440 1450
VTSEVINVLI NKDQNLVIEK GDNWTIISGV AVLPHVDQVT LCDIPGDIPI
1460 1470 1480 1490 1500
SQDQGELEAG CIPVTSAEKS PEASHTGPAF QEAPCGNNLS CPQEDVSSSG
1510 1520 1530 1540 1550
QSTNFDKSRL RNRPVKPSIW ISSQIYDQNF ETQIVASDHT YYNSKLEPSG
1560 1570 1580 1590 1600
KNKNRSKISN KDQSNKPVKT SASSRVETHQ SEVAQSFSGE KANTKTQRSQ
1610 1620 1630 1640 1650
TQTILANADT STPTDCSPDT LSKIRQEVGP PLPPLLAPLI ATPPRTSQPL
1660 1670 1680 1690 1700
SPLISSSSPS SPASPVGQVS PFRETPVPPA MSPWPEDPRR ASPPDPSPSP
1710 1720 1730 1740 1750
SAASASERVV PSPLQFCAAT PKHALPVPGR LPPCASGHAA VGGPQENSVK
1760 1770 1780 1790 1800
ILDTMYPELS ARARTLNILK GNIQLTRGPP ADCKNLPGPA SAMIGFKTIT
1810 1820 1830 1840 1850
SAATAFVKTG SSSGGDCNQD KSRDLGTQQD SSGKRTLSTS TLRSAKRLRL
1860 1870 1880 1890 1900
DTGSPEPETR GVTAEGIHKN LPGNLPPAEV ATTNEERSCS SPAVSAVSQL
1910 1920 1930 1940 1950
PLSPKETVES HDKAIANALK KIAEFSFDLL PVIRSHVYVG NISKKPVMRD
1960 1970 1980 1990 2000
QEKEVVYEFS TTKKHLAECL LHSILSELKI QKISMDHNYI HALCRVYVGI
2010 2020 2030 2040 2050
CRQLGDLERA RLFCYSLLKE DFPESEKLTL FIANMWHDIF LSQSVINKAM
2060 2070 2080 2090 2100
QLVARQRAKG EVLNCLRAFL NWEKNAPVDV GFMVSKLLLT IQLCPKTEFQ
2110 2120 2130 2140 2150
PSEKFGEDLS DNTWEYIFAI DLLCCHQKWI WTHDNIISKE LWPVMDKWIK
2160 2170 2180 2190 2200
YRKGHANIAY TPDIIIASIL RLIGRLGQLG LKEGFPSAVK NISSVIGMFI
2210 2220 2230 2240 2250
QHAHDEDIPW GIQLAAVYAL CDLSPSNPAE ISKILEAWRR EASKSVPSAI
2260
VSCLEEVSAL STEELG
Length:2,266
Mass (Da):247,891
Last modified:May 18, 2010 - v5
Checksum:i69EC121F4543B92D
GO

Sequence cautioni

The sequence BAA76791 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC86755 differs from that shown.Aberrant splicing.Curated
The sequence CAB70661 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAB70661 differs from that shown. Reason: Erroneous termination at position 2051. Translated as Gln.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti465 – 4651T → S in BAC86755 (PubMed:14702039).Curated
Sequence conflicti757 – 7571P → G in CAD97966 (PubMed:17974005).Curated
Sequence conflicti821 – 8211K → R in CAH18279 (PubMed:17974005).Curated
Sequence conflicti1112 – 11121E → V in CAH18279 (PubMed:17974005).Curated
Sequence conflicti1186 – 11861D → G in CAD97966 (PubMed:17974005).Curated
Sequence conflicti1756 – 17561Y → F in CAD97966 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti391 – 3911C → S.2 Publications
Corresponds to variant rs2619844 [ dbSNP | Ensembl ].
VAR_033341
Natural varianti596 – 5961K → E.
Corresponds to variant rs10475299 [ dbSNP | Ensembl ].
VAR_033342
Natural varianti901 – 9011V → I.3 Publications
Corresponds to variant rs2578500 [ dbSNP | Ensembl ].
VAR_033343
Natural varianti1054 – 10541T → A.
Corresponds to variant rs3806873 [ dbSNP | Ensembl ].
VAR_033344
Natural varianti1058 – 10581G → D.
Corresponds to variant rs3806874 [ dbSNP | Ensembl ].
VAR_033345
Natural varianti1597 – 15971Q → P.
Corresponds to variant rs10065646 [ dbSNP | Ensembl ].
VAR_033346
Natural varianti1618 – 16181P → L.
Corresponds to variant rs3747731 [ dbSNP | Ensembl ].
VAR_055943

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023164 mRNA. Translation: BAA76791.3. Different initiation.
AC010253 Genomic DNA. No translation available.
AC012607 Genomic DNA. No translation available.
AK126937 mRNA. Translation: BAC86755.1. Sequence problems.
AL137260 mRNA. Translation: CAB70661.1. Sequence problems.
BX538020 mRNA. Translation: CAD97966.1.
CR749441 mRNA. Translation: CAH18279.1.
BC004902 mRNA. Translation: AAH04902.2.
CCDSiCCDS47187.1.
PIRiT46331.
RefSeqiNP_056140.1. NM_015325.2.
UniGeneiHs.449296.

Genome annotation databases

EnsembliENST00000296564; ENSP00000296564; ENSG00000164151.
GeneIDi23379.
KEGGihsa:23379.
UCSCiuc003jdm.6. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023164 mRNA. Translation: BAA76791.3. Different initiation.
AC010253 Genomic DNA. No translation available.
AC012607 Genomic DNA. No translation available.
AK126937 mRNA. Translation: BAC86755.1. Sequence problems.
AL137260 mRNA. Translation: CAB70661.1. Sequence problems.
BX538020 mRNA. Translation: CAD97966.1.
CR749441 mRNA. Translation: CAH18279.1.
BC004902 mRNA. Translation: AAH04902.2.
CCDSiCCDS47187.1.
PIRiT46331.
RefSeqiNP_056140.1. NM_015325.2.
UniGeneiHs.449296.

3D structure databases

ProteinModelPortaliQ9Y2F5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116955. 20 interactions.
IntActiQ9Y2F5. 17 interactions.
MINTiMINT-8247375.
STRINGi9606.ENSP00000296564.

PTM databases

iPTMnetiQ9Y2F5.
PhosphoSiteiQ9Y2F5.

Polymorphism and mutation databases

BioMutaiKIAA0947.
DMDMi296439500.

Proteomic databases

EPDiQ9Y2F5.
MaxQBiQ9Y2F5.
PaxDbiQ9Y2F5.
PeptideAtlasiQ9Y2F5.
PRIDEiQ9Y2F5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296564; ENSP00000296564; ENSG00000164151.
GeneIDi23379.
KEGGihsa:23379.
UCSCiuc003jdm.6. human.

Organism-specific databases

CTDi23379.
GeneCardsiICE1.
HGNCiHGNC:29154. ICE1.
HPAiHPA054452.
HPA061934.
neXtProtiNX_Q9Y2F5.
PharmGKBiPA162411094.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE47. Eukaryota.
ENOG4111F6B. LUCA.
GeneTreeiENSGT00530000064287.
HOGENOMiHOG000168419.
HOVERGENiHBG108025.
InParanoidiQ9Y2F5.
OMAiLFIANMW.
OrthoDBiEOG091G00AF.
PhylomeDBiQ9Y2F5.
TreeFamiTF330760.

Enzyme and pathway databases

ReactomeiR-HSA-6807505. RNA polymerase II transcribes snRNA genes.

Miscellaneous databases

ChiTaRSiKIAA0947. human.
GenomeRNAii23379.
PROiQ9Y2F5.

Gene expression databases

BgeeiENSG00000164151.
ExpressionAtlasiQ9Y2F5. baseline and differential.
GenevisibleiQ9Y2F5. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiICE1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2F5
Secondary accession number(s): Q68DE1
, Q6ZT40, Q7L587, Q7Z3A9, Q9NTH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: May 18, 2010
Last modified: September 7, 2016
This is version 104 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.