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Q9Y2E6

- DTX4_HUMAN

UniProt

Q9Y2E6 - DTX4_HUMAN

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Protein

E3 ubiquitin-protein ligase DTX4

Gene

DTX4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations (By similarity). Functions as a ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4.By similarity1 Publication

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri409 – 46860RING-type; atypicalPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. innate immune response Source: Reactome
  2. Notch signaling pathway Source: UniProtKB-KW
  3. positive regulation of type I interferon production Source: Reactome
  4. protein ubiquitination Source: UniProtKB-UniPathway
  5. regulation of type I interferon production Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Notch signaling pathway, Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_118614. Activated NOTCH1 Transmits Signal to the Nucleus.
REACT_118811. IRF3 mediated activation of type 1 IFN.
REACT_163977. Regulation of innate immune responses to cytosolic DNA.
REACT_163993. IRF3-mediated induction of type I IFN.
SignaLinkiQ9Y2E6.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase DTX4 (EC:6.3.2.-)
Alternative name(s):
Protein deltex-4
Short name:
Deltex4
RING finger protein 155
Gene namesi
Name:DTX4
Synonyms:KIAA0937, RNF155
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:29151. DTX4.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytosol Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134930720.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 619619E3 ubiquitin-protein ligase DTX4PRO_0000280555Add
BLAST

Proteomic databases

PaxDbiQ9Y2E6.
PRIDEiQ9Y2E6.

PTM databases

PhosphoSiteiQ9Y2E6.

Expressioni

Gene expression databases

BgeeiQ9Y2E6.
CleanExiHS_DTX4.
GenevestigatoriQ9Y2E6.

Organism-specific databases

HPAiHPA056760.
HPA059294.

Interactioni

Subunit structurei

Interacts with NLRP4.1 Publication

Protein-protein interaction databases

BioGridi116827. 3 interactions.
IntActiQ9Y2E6. 1 interaction.
STRINGi9606.ENSP00000227451.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2E6.
SMRiQ9Y2E6. Positions 4-164, 390-609.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 7878WWE 1PROSITE-ProRule annotationAdd
BLAST
Domaini79 – 15577WWE 2PROSITE-ProRule annotationAdd
BLAST

Domaini

The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases.By similarity

Sequence similaritiesi

Belongs to the Deltex family.Curated
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation
Contains 2 WWE domains.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri409 – 46860RING-type; atypicalPROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG84763.
GeneTreeiENSGT00440000035370.
HOGENOMiHOG000007352.
HOVERGENiHBG007213.
InParanoidiQ9Y2E6.
KOiK06058.
OMAiQSWPVSP.
OrthoDBiEOG7J17ZB.
PhylomeDBiQ9Y2E6.
TreeFamiTF325526.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR004170. WWE-dom.
IPR018123. WWE-dom_subgr.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF02825. WWE. 2 hits.
PF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
SM00678. WWE. 2 hits.
[Graphical view]
PROSITEiPS50918. WWE. 2 hits.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9Y2E6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLASAVVVW EWLNEHGRWR PYSPAVSHHI EAVVRAGPRA GGSVVLGQVD
60 70 80 90 100
SRLAPYIIDL QSMNQFRQDT GTLRPVRRNY YDPSSAPGKG VVWEWENDNG
110 120 130 140 150
SWTPYDMEVG ITIQHAYEKQ HPWIDLTSIG FSYVIDFNTM GQINRQTQRQ
160 170 180 190 200
RRVRRRLDLI YPMVTGTLPK AQSWPVSPGP ATSPPMSPCS CPQCVLVMSV
210 220 230 240 250
KAAVVNGSTG PLQLPVTRKN MPPPGVVKLP PLPGSGAKPL DSTGTIRGPL
260 270 280 290 300
KTAPSQVIRR QASSMPTGTT MGSPASPPGP NSKTGRVALA TLNRTNLQRL
310 320 330 340 350
AIAQSRVLIA SGVPTVPVKN LNGSSPVNPA LAGITGILMS AAGLPVCLTR
360 370 380 390 400
PPKLVLHPPP VSKSEIKSIP GVSNTSRKTT KKQAKKGKTP EEVLKKYLQK
410 420 430 440 450
VRHPPDEDCT ICMERLTAPS GYKGPQPTVK PDLVGKLSRC GHVYHIYCLV
460 470 480 490 500
AMYNNGNKDG SLQCPTCKTI YGVKTGTQPP GKMEYHLIPH SLPGHPDCKT
510 520 530 540 550
IRIIYSIPPG IQGPEHPNPG KSFSARGFPR HCYLPDSEKG RKVLKLLLVA
560 570 580 590 600
WDRRLIFAIG TSSTTGESDT VIWNEVHHKT EFGSNLTGHG YPDANYLDNV
610
LAELAAQGIS EDSTAQEKD
Length:619
Mass (Da):67,258
Last modified:March 20, 2007 - v2
Checksum:i5C851845B42630BD
GO
Isoform 2 (identifier: Q9Y2E6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-106: Missing.

Show »
Length:513
Mass (Da):55,284
Checksum:iCBC72BC1D20CDD5C
GO

Sequence cautioni

The sequence BAA76781.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 106106Missing in isoform 2. 1 PublicationVSP_023784Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023154 mRNA. Translation: BAA76781.1. Different initiation.
BC119011 mRNA. Translation: AAI19012.1.
BC122861 mRNA. Translation: AAI22862.1.
CCDSiCCDS44612.1. [Q9Y2E6-1]
RefSeqiNP_001287656.1. NM_001300727.1. [Q9Y2E6-2]
NP_055992.1. NM_015177.1. [Q9Y2E6-1]
XP_006718546.1. XM_006718483.1. [Q9Y2E6-2]
UniGeneiHs.523696.

Genome annotation databases

EnsembliENST00000227451; ENSP00000227451; ENSG00000110042. [Q9Y2E6-1]
ENST00000532982; ENSP00000434055; ENSG00000110042. [Q9Y2E6-2]
GeneIDi23220.
KEGGihsa:23220.
UCSCiuc001nnr.2. human. [Q9Y2E6-1]

Polymorphism databases

DMDMi134034097.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023154 mRNA. Translation: BAA76781.1 . Different initiation.
BC119011 mRNA. Translation: AAI19012.1 .
BC122861 mRNA. Translation: AAI22862.1 .
CCDSi CCDS44612.1. [Q9Y2E6-1 ]
RefSeqi NP_001287656.1. NM_001300727.1. [Q9Y2E6-2 ]
NP_055992.1. NM_015177.1. [Q9Y2E6-1 ]
XP_006718546.1. XM_006718483.1. [Q9Y2E6-2 ]
UniGenei Hs.523696.

3D structure databases

ProteinModelPortali Q9Y2E6.
SMRi Q9Y2E6. Positions 4-164, 390-609.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116827. 3 interactions.
IntActi Q9Y2E6. 1 interaction.
STRINGi 9606.ENSP00000227451.

PTM databases

PhosphoSitei Q9Y2E6.

Polymorphism databases

DMDMi 134034097.

Proteomic databases

PaxDbi Q9Y2E6.
PRIDEi Q9Y2E6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000227451 ; ENSP00000227451 ; ENSG00000110042 . [Q9Y2E6-1 ]
ENST00000532982 ; ENSP00000434055 ; ENSG00000110042 . [Q9Y2E6-2 ]
GeneIDi 23220.
KEGGi hsa:23220.
UCSCi uc001nnr.2. human. [Q9Y2E6-1 ]

Organism-specific databases

CTDi 23220.
GeneCardsi GC11P058939.
HGNCi HGNC:29151. DTX4.
HPAi HPA056760.
HPA059294.
neXtProti NX_Q9Y2E6.
PharmGKBi PA134930720.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG84763.
GeneTreei ENSGT00440000035370.
HOGENOMi HOG000007352.
HOVERGENi HBG007213.
InParanoidi Q9Y2E6.
KOi K06058.
OMAi QSWPVSP.
OrthoDBi EOG7J17ZB.
PhylomeDBi Q9Y2E6.
TreeFami TF325526.

Enzyme and pathway databases

UniPathwayi UPA00143 .
Reactomei REACT_118614. Activated NOTCH1 Transmits Signal to the Nucleus.
REACT_118811. IRF3 mediated activation of type 1 IFN.
REACT_163977. Regulation of innate immune responses to cytosolic DNA.
REACT_163993. IRF3-mediated induction of type I IFN.
SignaLinki Q9Y2E6.

Miscellaneous databases

ChiTaRSi DTX4. human.
GenomeRNAii 23220.
NextBioi 44807.
PROi Q9Y2E6.

Gene expression databases

Bgeei Q9Y2E6.
CleanExi HS_DTX4.
Genevestigatori Q9Y2E6.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR004170. WWE-dom.
IPR018123. WWE-dom_subgr.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF02825. WWE. 2 hits.
PF13639. zf-RING_2. 1 hit.
[Graphical view ]
SMARTi SM00184. RING. 1 hit.
SM00678. WWE. 2 hits.
[Graphical view ]
PROSITEi PS50918. WWE. 2 hits.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  3. "Normal immune system development in mice lacking the Deltex-1 RING finger domain."
    Storck S., Delbos F., Stadler N., Thirion-Delalande C., Bernex F., Verthuy C., Ferrier P., Weill J.-C., Reynaud C.-A.
    Mol. Cell. Biol. 25:1437-1445(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  4. "NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4."
    Cui J., Li Y., Zhu L., Liu D., Songyang Z., Wang H.Y., Wang R.F.
    Nat. Immunol. 13:387-395(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS E3 LIGASE, INTERACTION WITH NLRP4.

Entry informationi

Entry nameiDTX4_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2E6
Secondary accession number(s): Q0VF38
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: November 26, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3