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Q9Y2E6

- DTX4_HUMAN

UniProt

Q9Y2E6 - DTX4_HUMAN

Protein

E3 ubiquitin-protein ligase DTX4

Gene

DTX4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (20 Mar 2007)
      Previous versions | rss
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    Functioni

    Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations By similarity. Functions as a ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4.By similarity1 Publication

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri409 – 46860RING-type; atypicalPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. innate immune response Source: Reactome
    2. Notch signaling pathway Source: UniProtKB-KW
    3. positive regulation of type I interferon production Source: Reactome
    4. protein ubiquitination Source: UniProtKB-UniPathway
    5. regulation of type I interferon production Source: Reactome

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Notch signaling pathway, Ubl conjugation pathway

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_118614. Activated NOTCH1 Transmits Signal to the Nucleus.
    REACT_118811. IRF3 mediated activation of type 1 IFN.
    REACT_163977. Regulation of innate immune responses to cytosolic DNA.
    REACT_163993. IRF3-mediated induction of type I IFN.
    SignaLinkiQ9Y2E6.
    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    E3 ubiquitin-protein ligase DTX4 (EC:6.3.2.-)
    Alternative name(s):
    Protein deltex-4
    Short name:
    Deltex4
    RING finger protein 155
    Gene namesi
    Name:DTX4
    Synonyms:KIAA0937, RNF155
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:29151. DTX4.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytosol Source: Reactome

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134930720.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 619619E3 ubiquitin-protein ligase DTX4PRO_0000280555Add
    BLAST

    Proteomic databases

    PaxDbiQ9Y2E6.
    PRIDEiQ9Y2E6.

    PTM databases

    PhosphoSiteiQ9Y2E6.

    Expressioni

    Gene expression databases

    BgeeiQ9Y2E6.
    CleanExiHS_DTX4.
    GenevestigatoriQ9Y2E6.

    Organism-specific databases

    HPAiHPA056760.
    HPA059294.

    Interactioni

    Subunit structurei

    Interacts with NLRP4.1 Publication

    Protein-protein interaction databases

    BioGridi116827. 3 interactions.
    IntActiQ9Y2E6. 1 interaction.
    STRINGi9606.ENSP00000227451.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y2E6.
    SMRiQ9Y2E6. Positions 4-164, 390-609.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 7878WWE 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini79 – 15577WWE 2PROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases.By similarity

    Sequence similaritiesi

    Belongs to the Deltex family.Curated
    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation
    Contains 2 WWE domains.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri409 – 46860RING-type; atypicalPROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG84763.
    HOGENOMiHOG000007352.
    HOVERGENiHBG007213.
    InParanoidiQ9Y2E6.
    KOiK06058.
    OMAiQSWPVSP.
    OrthoDBiEOG7J17ZB.
    PhylomeDBiQ9Y2E6.
    TreeFamiTF325526.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR004170. WWE-dom.
    IPR018123. WWE-dom_subgr.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF02825. WWE. 2 hits.
    PF13639. zf-RING_2. 1 hit.
    [Graphical view]
    SMARTiSM00184. RING. 1 hit.
    SM00678. WWE. 2 hits.
    [Graphical view]
    PROSITEiPS50918. WWE. 2 hits.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y2E6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLLASAVVVW EWLNEHGRWR PYSPAVSHHI EAVVRAGPRA GGSVVLGQVD    50
    SRLAPYIIDL QSMNQFRQDT GTLRPVRRNY YDPSSAPGKG VVWEWENDNG 100
    SWTPYDMEVG ITIQHAYEKQ HPWIDLTSIG FSYVIDFNTM GQINRQTQRQ 150
    RRVRRRLDLI YPMVTGTLPK AQSWPVSPGP ATSPPMSPCS CPQCVLVMSV 200
    KAAVVNGSTG PLQLPVTRKN MPPPGVVKLP PLPGSGAKPL DSTGTIRGPL 250
    KTAPSQVIRR QASSMPTGTT MGSPASPPGP NSKTGRVALA TLNRTNLQRL 300
    AIAQSRVLIA SGVPTVPVKN LNGSSPVNPA LAGITGILMS AAGLPVCLTR 350
    PPKLVLHPPP VSKSEIKSIP GVSNTSRKTT KKQAKKGKTP EEVLKKYLQK 400
    VRHPPDEDCT ICMERLTAPS GYKGPQPTVK PDLVGKLSRC GHVYHIYCLV 450
    AMYNNGNKDG SLQCPTCKTI YGVKTGTQPP GKMEYHLIPH SLPGHPDCKT 500
    IRIIYSIPPG IQGPEHPNPG KSFSARGFPR HCYLPDSEKG RKVLKLLLVA 550
    WDRRLIFAIG TSSTTGESDT VIWNEVHHKT EFGSNLTGHG YPDANYLDNV 600
    LAELAAQGIS EDSTAQEKD 619
    Length:619
    Mass (Da):67,258
    Last modified:March 20, 2007 - v2
    Checksum:i5C851845B42630BD
    GO
    Isoform 2 (identifier: Q9Y2E6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-106: Missing.

    Show »
    Length:513
    Mass (Da):55,284
    Checksum:iCBC72BC1D20CDD5C
    GO

    Sequence cautioni

    The sequence BAA76781.1 differs from that shown. Reason: Erroneous initiation.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 106106Missing in isoform 2. 1 PublicationVSP_023784Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB023154 mRNA. Translation: BAA76781.1. Different initiation.
    BC119011 mRNA. Translation: AAI19012.1.
    BC122861 mRNA. Translation: AAI22862.1.
    CCDSiCCDS44612.1. [Q9Y2E6-1]
    RefSeqiNP_055992.1. NM_015177.1. [Q9Y2E6-1]
    XP_006718546.1. XM_006718483.1. [Q9Y2E6-2]
    UniGeneiHs.523696.

    Genome annotation databases

    EnsembliENST00000227451; ENSP00000227451; ENSG00000110042. [Q9Y2E6-1]
    ENST00000532982; ENSP00000434055; ENSG00000110042. [Q9Y2E6-2]
    GeneIDi23220.
    KEGGihsa:23220.
    UCSCiuc001nnr.2. human. [Q9Y2E6-1]

    Polymorphism databases

    DMDMi134034097.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB023154 mRNA. Translation: BAA76781.1 . Different initiation.
    BC119011 mRNA. Translation: AAI19012.1 .
    BC122861 mRNA. Translation: AAI22862.1 .
    CCDSi CCDS44612.1. [Q9Y2E6-1 ]
    RefSeqi NP_055992.1. NM_015177.1. [Q9Y2E6-1 ]
    XP_006718546.1. XM_006718483.1. [Q9Y2E6-2 ]
    UniGenei Hs.523696.

    3D structure databases

    ProteinModelPortali Q9Y2E6.
    SMRi Q9Y2E6. Positions 4-164, 390-609.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116827. 3 interactions.
    IntActi Q9Y2E6. 1 interaction.
    STRINGi 9606.ENSP00000227451.

    PTM databases

    PhosphoSitei Q9Y2E6.

    Polymorphism databases

    DMDMi 134034097.

    Proteomic databases

    PaxDbi Q9Y2E6.
    PRIDEi Q9Y2E6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000227451 ; ENSP00000227451 ; ENSG00000110042 . [Q9Y2E6-1 ]
    ENST00000532982 ; ENSP00000434055 ; ENSG00000110042 . [Q9Y2E6-2 ]
    GeneIDi 23220.
    KEGGi hsa:23220.
    UCSCi uc001nnr.2. human. [Q9Y2E6-1 ]

    Organism-specific databases

    CTDi 23220.
    GeneCardsi GC11P058939.
    HGNCi HGNC:29151. DTX4.
    HPAi HPA056760.
    HPA059294.
    neXtProti NX_Q9Y2E6.
    PharmGKBi PA134930720.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG84763.
    HOGENOMi HOG000007352.
    HOVERGENi HBG007213.
    InParanoidi Q9Y2E6.
    KOi K06058.
    OMAi QSWPVSP.
    OrthoDBi EOG7J17ZB.
    PhylomeDBi Q9Y2E6.
    TreeFami TF325526.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .
    Reactomei REACT_118614. Activated NOTCH1 Transmits Signal to the Nucleus.
    REACT_118811. IRF3 mediated activation of type 1 IFN.
    REACT_163977. Regulation of innate immune responses to cytosolic DNA.
    REACT_163993. IRF3-mediated induction of type I IFN.
    SignaLinki Q9Y2E6.

    Miscellaneous databases

    ChiTaRSi DTX4. human.
    GenomeRNAii 23220.
    NextBioi 44807.
    PROi Q9Y2E6.

    Gene expression databases

    Bgeei Q9Y2E6.
    CleanExi HS_DTX4.
    Genevestigatori Q9Y2E6.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR004170. WWE-dom.
    IPR018123. WWE-dom_subgr.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF02825. WWE. 2 hits.
    PF13639. zf-RING_2. 1 hit.
    [Graphical view ]
    SMARTi SM00184. RING. 1 hit.
    SM00678. WWE. 2 hits.
    [Graphical view ]
    PROSITEi PS50918. WWE. 2 hits.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    3. "Normal immune system development in mice lacking the Deltex-1 RING finger domain."
      Storck S., Delbos F., Stadler N., Thirion-Delalande C., Bernex F., Verthuy C., Ferrier P., Weill J.-C., Reynaud C.-A.
      Mol. Cell. Biol. 25:1437-1445(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    4. "NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4."
      Cui J., Li Y., Zhu L., Liu D., Songyang Z., Wang H.Y., Wang R.F.
      Nat. Immunol. 13:387-395(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS E3 LIGASE, INTERACTION WITH NLRP4.

    Entry informationi

    Entry nameiDTX4_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y2E6
    Secondary accession number(s): Q0VF38
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: March 20, 2007
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3