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Q9Y2E6 (DTX4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
E3 ubiquitin-protein ligase DTX4

EC=6.3.2.-
Alternative name(s):
Protein deltex-4
Short name=Deltex4
RING finger protein 155
Gene names
Name:DTX4
Synonyms:KIAA0937, RNF155
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length619 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations By similarity. Functions as a ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4. Ref.4

Pathway

Protein modification; protein ubiquitination.

Subunit structure

Interacts with NLRP4. Ref.4

Subcellular location

Cytoplasm By similarity.

Domain

The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases By similarity.

Sequence similarities

Belongs to the Deltex family.

Contains 1 RING-type zinc finger.

Contains 2 WWE domains.

Sequence caution

The sequence BAA76781.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9Y2E6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9Y2E6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-106: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 619619E3 ubiquitin-protein ligase DTX4
PRO_0000280555

Regions

Domain1 – 7878WWE 1
Domain79 – 15577WWE 2
Zinc finger409 – 46860RING-type; atypical

Natural variations

Alternative sequence1 – 106106Missing in isoform 2.
VSP_023784

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 20, 2007. Version 2.
Checksum: 5C851845B42630BD

FASTA61967,258
        10         20         30         40         50         60 
MLLASAVVVW EWLNEHGRWR PYSPAVSHHI EAVVRAGPRA GGSVVLGQVD SRLAPYIIDL 

        70         80         90        100        110        120 
QSMNQFRQDT GTLRPVRRNY YDPSSAPGKG VVWEWENDNG SWTPYDMEVG ITIQHAYEKQ 

       130        140        150        160        170        180 
HPWIDLTSIG FSYVIDFNTM GQINRQTQRQ RRVRRRLDLI YPMVTGTLPK AQSWPVSPGP 

       190        200        210        220        230        240 
ATSPPMSPCS CPQCVLVMSV KAAVVNGSTG PLQLPVTRKN MPPPGVVKLP PLPGSGAKPL 

       250        260        270        280        290        300 
DSTGTIRGPL KTAPSQVIRR QASSMPTGTT MGSPASPPGP NSKTGRVALA TLNRTNLQRL 

       310        320        330        340        350        360 
AIAQSRVLIA SGVPTVPVKN LNGSSPVNPA LAGITGILMS AAGLPVCLTR PPKLVLHPPP 

       370        380        390        400        410        420 
VSKSEIKSIP GVSNTSRKTT KKQAKKGKTP EEVLKKYLQK VRHPPDEDCT ICMERLTAPS 

       430        440        450        460        470        480 
GYKGPQPTVK PDLVGKLSRC GHVYHIYCLV AMYNNGNKDG SLQCPTCKTI YGVKTGTQPP 

       490        500        510        520        530        540 
GKMEYHLIPH SLPGHPDCKT IRIIYSIPPG IQGPEHPNPG KSFSARGFPR HCYLPDSEKG 

       550        560        570        580        590        600 
RKVLKLLLVA WDRRLIFAIG TSSTTGESDT VIWNEVHHKT EFGSNLTGHG YPDANYLDNV 

       610 
LAELAAQGIS EDSTAQEKD 

« Hide

Isoform 2 [UniParc].

Checksum: CBC72BC1D20CDD5C
Show »

FASTA51355,284

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[3]"Normal immune system development in mice lacking the Deltex-1 RING finger domain."
Storck S., Delbos F., Stadler N., Thirion-Delalande C., Bernex F., Verthuy C., Ferrier P., Weill J.-C., Reynaud C.-A.
Mol. Cell. Biol. 25:1437-1445(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[4]"NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4."
Cui J., Li Y., Zhu L., Liu D., Songyang Z., Wang H.Y., Wang R.F.
Nat. Immunol. 13:387-395(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION AS E3 LIGASE, INTERACTION WITH NLRP4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB023154 mRNA. Translation: BAA76781.1. Different initiation.
BC119011 mRNA. Translation: AAI19012.1.
BC122861 mRNA. Translation: AAI22862.1.
CCDSCCDS44612.1. [Q9Y2E6-1]
RefSeqNP_055992.1. NM_015177.1. [Q9Y2E6-1]
XP_006718546.1. XM_006718483.1. [Q9Y2E6-2]
UniGeneHs.523696.

3D structure databases

ProteinModelPortalQ9Y2E6.
SMRQ9Y2E6. Positions 4-164, 390-609.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116827. 3 interactions.
IntActQ9Y2E6. 1 interaction.
STRING9606.ENSP00000227451.

PTM databases

PhosphoSiteQ9Y2E6.

Polymorphism databases

DMDM134034097.

Proteomic databases

PaxDbQ9Y2E6.
PRIDEQ9Y2E6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000227451; ENSP00000227451; ENSG00000110042. [Q9Y2E6-1]
ENST00000532982; ENSP00000434055; ENSG00000110042. [Q9Y2E6-2]
GeneID23220.
KEGGhsa:23220.
UCSCuc001nnr.2. human. [Q9Y2E6-1]

Organism-specific databases

CTD23220.
GeneCardsGC11P058939.
HGNCHGNC:29151. DTX4.
HPAHPA056760.
HPA059294.
neXtProtNX_Q9Y2E6.
PharmGKBPA134930720.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG84763.
HOGENOMHOG000007352.
HOVERGENHBG007213.
InParanoidQ9Y2E6.
KOK06058.
OMAQSWPVSP.
OrthoDBEOG7J17ZB.
PhylomeDBQ9Y2E6.
TreeFamTF325526.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
REACT_116125. Disease.
REACT_6900. Immune System.
SignaLinkQ9Y2E6.
UniPathwayUPA00143.

Gene expression databases

BgeeQ9Y2E6.
CleanExHS_DTX4.
GenevestigatorQ9Y2E6.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
InterProIPR004170. WWE-dom.
IPR018123. WWE-dom_subgr.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamPF02825. WWE. 2 hits.
PF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTSM00184. RING. 1 hit.
SM00678. WWE. 2 hits.
[Graphical view]
PROSITEPS50918. WWE. 2 hits.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSDTX4. human.
GenomeRNAi23220.
NextBio44807.
PROQ9Y2E6.

Entry information

Entry nameDTX4_HUMAN
AccessionPrimary (citable) accession number: Q9Y2E6
Secondary accession number(s): Q0VF38
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: July 9, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM