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Protein

Disco-interacting protein 2 homolog C

Gene

DIP2C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Disco-interacting protein 2 homolog C
Short name:
DIP2 homolog C
Gene namesi
Name:DIP2C
Synonyms:KIAA0934
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:29150. DIP2C.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134961070.

Polymorphism and mutation databases

BioMutaiDIP2C.
DMDMi29429225.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15561556Disco-interacting protein 2 homolog CPRO_0000050782Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei264 – 2641PhosphothreonineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y2E4.
MaxQBiQ9Y2E4.
PaxDbiQ9Y2E4.
PRIDEiQ9Y2E4.

PTM databases

iPTMnetiQ9Y2E4.
PhosphoSiteiQ9Y2E4.

Expressioni

Gene expression databases

BgeeiQ9Y2E4.
CleanExiHS_DIP2C.
ExpressionAtlasiQ9Y2E4. baseline and differential.
GenevisibleiQ9Y2E4. HS.

Organism-specific databases

HPAiHPA030264.

Interactioni

Protein-protein interaction databases

BioGridi116631. 2 interactions.
STRINGi9606.ENSP00000280886.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2E4.
SMRiQ9Y2E4. Positions 371-888, 972-1556.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 119111DMAP-interactionAdd
BLAST

Sequence similaritiesi

Belongs to the DIP2 family.Curated
Contains 1 DMAP-interaction domain.Curated

Phylogenomic databases

eggNOGiKOG3628. Eukaryota.
COG0318. LUCA.
GeneTreeiENSGT00390000005268.
HOGENOMiHOG000045270.
HOVERGENiHBG026594.
InParanoidiQ9Y2E4.
OMAiAEDCERK.
OrthoDBiEOG7D59MW.
PhylomeDBiQ9Y2E4.
TreeFamiTF312871.

Family and domain databases

InterProiIPR000873. AMP-dep_Synth/Lig.
IPR010506. DMAP1-bd.
[Graphical view]
PfamiPF00501. AMP-binding. 2 hits.
PF06464. DMAP_binding. 1 hit.
[Graphical view]
SMARTiSM01137. DMAP_binding. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y2E4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADRSLEGMA LPLEVRARLA ELELELSEGD ITQKGYEKKR SKLIGAYLPQ
60 70 80 90 100
PPRVDQALPQ ERRAPVTPSS ASRYHRRRSS GSRDERYRSD VHTEAVQAAL
110 120 130 140 150
AKHKERKMAV PMPSKRRSLV VQTSMDAYTP PDTSSGSEDE GSVQGDSQGT
160 170 180 190 200
PTSSQGSINM EHWISQAIHG STTSTTSSSS TQSGGSGAAH RLADVMAQTH
210 220 230 240 250
IENHSAPPDV TTYTSEHSIQ VERPQGSTGS RTAPKYGNAE LMETGDGVPV
260 270 280 290 300
SSRVSAKIQQ LVNTLKRPKR PPLREFFVDD FEELLEVQQP DPNQPKPEGA
310 320 330 340 350
QMLAMRGEQL GVVTNWPPSL EAALQRWGTI SPKAPCLTTM DTNGKPLYIL
360 370 380 390 400
TYGKLWTRSM KVAYSILHKL GTKQEPMVRP GDRVALVFPN NDPAAFMAAF
410 420 430 440 450
YGCLLAEVVP VPIEVPLTRK DAGSQQIGFL LGSCGVTVAL TSDACHKGLP
460 470 480 490 500
KSPTGEIPQF KGWPKLLWFV TESKHLSKPP RDWFPHIKDA NNDTAYIEYK
510 520 530 540 550
TCKDGSVLGV TVTRTALLTH CQALTQACGY TEAETIVNVL DFKKDVGLWH
560 570 580 590 600
GILTSVMNMM HVISIPYSLM KVNPLSWIQK VCQYKAKVAC VKSRDMHWAL
610 620 630 640 650
VAHRDQRDIN LSSLRMLIVA DGANPWSISS CDAFLNVFQS KGLRQEVICP
660 670 680 690 700
CASSPEALTV AIRRPTDDSN QPPGRGVLSM HGLTYGVIRV DSEEKLSVLT
710 720 730 740 750
VQDVGLVMPG AIMCSVKPDG VPQLCRTDEI GELCVCAVAT GTSYYGLSGM
760 770 780 790 800
TKNTFEVFPM TSSGAPISEY PFIRTGLLGF VGPGGLVFVV GKMDGLMVVS
810 820 830 840 850
GRRHNADDIV ATALAVEPMK FVYRGRIAVF SVTVLHDERI VIVAEQRPDS
860 870 880 890 900
TEEDSFQWMS RVLQAIDSIH QVGVYCLALV PANTLPKTPL GGIHLSETKQ
910 920 930 940 950
LFLEGSLHPC NVLMCPHTCV TNLPKPRQKQ PEIGPASVMV GNLVSGKRIA
960 970 980 990 1000
QASGRDLGQI EDNDQARKFL FLSEVLQWRA QTTPDHILYT LLNCRGAIAN
1010 1020 1030 1040 1050
SLTCVQLHKR AEKIAVMLME RGHLQDGDHV ALVYPPGIDL IAAFYGCLYA
1060 1070 1080 1090 1100
GCVPITVRPP HPQNIATTLP TVKMIVEVSR SACLMTTQLI CKLLRSREAA
1110 1120 1130 1140 1150
AAVDVRTWPL ILDTDDLPKK RPAQICKPCN PDTLAYLDFS VSTTGMLAGV
1160 1170 1180 1190 1200
KMSHAATSAF CRSIKLQCEL YPSREVAICL DPYCGLGFVL WCLCSVYSGH
1210 1220 1230 1240 1250
QSILIPPSEL ETNPALWLLA VSQYKVRDTF CSYSVMELCT KGLGSQTESL
1260 1270 1280 1290 1300
KARGLDLSRV RTCVVVAEER PRIALTQSFS KLFKDLGLHP RAVSTSFGCR
1310 1320 1330 1340 1350
VNLAICLQGT SGPDPTTVYV DMRALRHDRV RLVERGSPHS LPLMESGKIL
1360 1370 1380 1390 1400
PGVRIIIANP ETKGPLGDSH LGEIWVHSAH NASGYFTIYG DESLQSDHFN
1410 1420 1430 1440 1450
SRLSFGDTQT IWARTGYLGF LRRTELTDAN GERHDALYVV GALDEAMELR
1460 1470 1480 1490 1500
GMRYHPIDIE TSVIRAHKSV TECAVFTWTN LLVVVVELDG SEQEALDLVP
1510 1520 1530 1540 1550
LVTNVVLEEH YLIVGVVVVV DIGVIPINSR GEKQRMHLRD GFLADQLDPI

YVAYNM
Length:1,556
Mass (Da):170,767
Last modified:March 28, 2003 - v2
Checksum:iE4CA7F0719C384EA
GO
Isoform 2 (identifier: Q9Y2E4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-679: Missing.
     996-1050: GAIANSLTCV...IAAFYGCLYA → VRRGAGLPWL...TETFVPRDCF
     1051-1556: Missing.

Note: No experimental confirmation available.
Show »
Length:371
Mass (Da):40,613
Checksum:i9F62E018E8DCFC50
GO

Sequence cautioni

The sequence BAA76778.2 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti586 – 5861A → E in a breast cancer sample; somatic mutation. 1 Publication
VAR_035905
Natural varianti622 – 6221G → S in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035906
Natural varianti1264 – 12641V → M in a breast cancer sample; somatic mutation. 1 Publication
VAR_035907

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 679679Missing in isoform 2. 1 PublicationVSP_056898Add
BLAST
Alternative sequencei996 – 105055GAIAN…GCLYA → VRRGAGLPWLLASRGLAWFL GALLLLSLNPFASVLWEFFL CFAILTETFVPRDCF in isoform 2. 1 PublicationVSP_056899Add
BLAST
Alternative sequencei1051 – 1556506Missing in isoform 2. 1 PublicationVSP_056900Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023151 mRNA. Translation: BAA76778.2. Different initiation.
AK298353 mRNA. Translation: BAG60597.1.
AL358216 Genomic DNA. No translation available.
AL157709
, AL359957, AL603831, AL669841 Genomic DNA. Translation: CAI39594.1.
AL359957
, AL157709, AL603831, AL669841 Genomic DNA. Translation: CAI16215.1.
AL603831
, AL157709, AL359957, AL669841 Genomic DNA. Translation: CAI40897.1.
AL669841
, AL157709, AL359957, AL603831 Genomic DNA. Translation: CAI14620.1.
BC063313 mRNA. Translation: AAH63313.1.
CCDSiCCDS7054.1. [Q9Y2E4-1]
RefSeqiNP_055789.1. NM_014974.2. [Q9Y2E4-1]
UniGeneiHs.432397.

Genome annotation databases

EnsembliENST00000280886; ENSP00000280886; ENSG00000151240. [Q9Y2E4-1]
GeneIDi22982.
KEGGihsa:22982.
UCSCiuc001ifp.4. human. [Q9Y2E4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023151 mRNA. Translation: BAA76778.2. Different initiation.
AK298353 mRNA. Translation: BAG60597.1.
AL358216 Genomic DNA. No translation available.
AL157709
, AL359957, AL603831, AL669841 Genomic DNA. Translation: CAI39594.1.
AL359957
, AL157709, AL603831, AL669841 Genomic DNA. Translation: CAI16215.1.
AL603831
, AL157709, AL359957, AL669841 Genomic DNA. Translation: CAI40897.1.
AL669841
, AL157709, AL359957, AL603831 Genomic DNA. Translation: CAI14620.1.
BC063313 mRNA. Translation: AAH63313.1.
CCDSiCCDS7054.1. [Q9Y2E4-1]
RefSeqiNP_055789.1. NM_014974.2. [Q9Y2E4-1]
UniGeneiHs.432397.

3D structure databases

ProteinModelPortaliQ9Y2E4.
SMRiQ9Y2E4. Positions 371-888, 972-1556.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116631. 2 interactions.
STRINGi9606.ENSP00000280886.

PTM databases

iPTMnetiQ9Y2E4.
PhosphoSiteiQ9Y2E4.

Polymorphism and mutation databases

BioMutaiDIP2C.
DMDMi29429225.

Proteomic databases

EPDiQ9Y2E4.
MaxQBiQ9Y2E4.
PaxDbiQ9Y2E4.
PRIDEiQ9Y2E4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000280886; ENSP00000280886; ENSG00000151240. [Q9Y2E4-1]
GeneIDi22982.
KEGGihsa:22982.
UCSCiuc001ifp.4. human. [Q9Y2E4-1]

Organism-specific databases

CTDi22982.
GeneCardsiDIP2C.
HGNCiHGNC:29150. DIP2C.
HPAiHPA030264.
MIMi611380. gene.
neXtProtiNX_Q9Y2E4.
PharmGKBiPA134961070.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3628. Eukaryota.
COG0318. LUCA.
GeneTreeiENSGT00390000005268.
HOGENOMiHOG000045270.
HOVERGENiHBG026594.
InParanoidiQ9Y2E4.
OMAiAEDCERK.
OrthoDBiEOG7D59MW.
PhylomeDBiQ9Y2E4.
TreeFamiTF312871.

Miscellaneous databases

ChiTaRSiDIP2C. human.
GenomeRNAii22982.
NextBioi35473880.
PROiQ9Y2E4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y2E4.
CleanExiHS_DIP2C.
ExpressionAtlasiQ9Y2E4. baseline and differential.
GenevisibleiQ9Y2E4. HS.

Family and domain databases

InterProiIPR000873. AMP-dep_Synth/Lig.
IPR010506. DMAP1-bd.
[Graphical view]
PfamiPF00501. AMP-binding. 2 hits.
PF06464. DMAP_binding. 1 hit.
[Graphical view]
SMARTiSM01137. DMAP_binding. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Kidney.
  4. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-264, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  7. Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLU-586; SER-622 AND MET-1264.

Entry informationi

Entry nameiDIP2C_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2E4
Secondary accession number(s): B4DPI5, Q5SS78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: March 28, 2003
Last modified: May 11, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.