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Protein

Zinc finger protein 652

Gene

ZNF652

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a transcriptional repressor.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri245 – 268C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri272 – 294C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri299 – 322C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri329 – 351C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri357 – 379C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri385 – 407C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri413 – 435C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri441 – 463C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri469 – 492C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-32282-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 652
Gene namesi
Name:ZNF652
Synonyms:KIAA0924
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:29147. ZNF652.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi22834.
OpenTargetsiENSG00000198740.
PharmGKBiPA134896615.

Polymorphism and mutation databases

BioMutaiZNF652.
DMDMi134035373.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002804281 – 606Zinc finger protein 652Add BLAST606

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei57PhosphoserineCombined sources1
Modified residuei100PhosphoserineBy similarity1
Modified residuei103PhosphothreonineBy similarity1
Modified residuei197PhosphoserineCombined sources1
Modified residuei204PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y2D9.
MaxQBiQ9Y2D9.
PaxDbiQ9Y2D9.
PeptideAtlasiQ9Y2D9.
PRIDEiQ9Y2D9.

PTM databases

iPTMnetiQ9Y2D9.
PhosphoSitePlusiQ9Y2D9.

Expressioni

Tissue specificityi

Widely expressed with higher expression in breast, prostate, vulva and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000198740.
CleanExiHS_ZNF652.
ExpressionAtlasiQ9Y2D9. baseline and differential.
GenevisibleiQ9Y2D9. HS.

Organism-specific databases

HPAiHPA044408.

Interactioni

Subunit structurei

Interacts with CBFA2T3.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CBFA2T3O750812EBI-1190229,EBI-1190217

Protein-protein interaction databases

IntActiQ9Y2D9. 4 interactors.
STRINGi9606.ENSP00000354686.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2D9.
SMRiQ9Y2D9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni498 – 606Mediates interaction with CBFA2T31 PublicationAdd BLAST109

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi74 – 183Glu-richAdd BLAST110
Compositional biasi497 – 574Pro-richAdd BLAST78

Sequence similaritiesi

Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri245 – 268C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri272 – 294C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri299 – 322C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri329 – 351C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri357 – 379C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri385 – 407C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri413 – 435C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri441 – 463C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri469 – 492C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00440000037877.
HOGENOMiHOG000231037.
HOVERGENiHBG064823.
InParanoidiQ9Y2D9.
OMAiFYHGASQ.
OrthoDBiEOG091G055W.
PhylomeDBiQ9Y2D9.
TreeFamiTF332655.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 9 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y2D9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHTASSCQE LVENCAVHVA GMAQEDSRRG QVPSSFYHGA NQELDLSTKV
60 70 80 90 100
YKRESGSPYS VLVDTKMSKP HLHETEEQPY FRETRAVSDV HAVKEDRENS
110 120 130 140 150
DDTEEEEEEV SYKREQIIVE VNLNNQTLNV SKGEKGVSSQ SKETPVLKTS
160 170 180 190 200
SEEEEEESEE EATDDSNDYG ENEKQKKKEK IVEKVSVTQR RTRRAASVAA
210 220 230 240 250
ATTSPTPRTT RGRRKSVEPP KRKKRATKEP KAPVQKAKCE EKETLTCEKC
260 270 280 290 300
PRVFNTRWYL EKHMNVTHRR MQICDKCGKK FVLESELSLH QQTDCEKNIQ
310 320 330 340 350
CVSCNKSFKK LWSLHEHIKI VHGYAEKKFS CEICEKKFYT MAHVRKHMVA
360 370 380 390 400
HTKDMPFTCE TCGKSFKRSM SLKVHSLQHS GEKPFRCENC DERFQYKYQL
410 420 430 440 450
RSHMSIHIGH KQFMCQWCGK DFNMKQYFDE HMKTHTGEKP FICEICGKSF
460 470 480 490 500
TSRPNMKRHR RTHTGEKPYP CDVCGQRFRF SNMLKAHKEK CFRVTSPVNV
510 520 530 540 550
PPAVQIPLTT SPATPVPSVV NTATTPTPPI NMNPVSTLPP RPIPHPFSHL
560 570 580 590 600
HIHPHPHHPH HLPIPPVPHL PPPPALFKSE PLNHRGQSED NFLRHLAEKN

SSAQHH
Length:606
Mass (Da):69,744
Last modified:March 20, 2007 - v3
Checksum:iC066D10E179985CC
GO

Sequence cautioni

The sequence BAA76768 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023141 mRNA. Translation: BAA76768.2. Different initiation.
CR933680 mRNA. Translation: CAI45974.1.
CH471109 Genomic DNA. Translation: EAW94682.1.
BC139779 mRNA. Translation: AAI39780.1.
BC152440 mRNA. Translation: AAI52441.1.
CCDSiCCDS32677.1.
RefSeqiNP_001138837.1. NM_001145365.1.
NP_055712.1. NM_014897.2.
UniGeneiHs.463375.
Hs.712948.

Genome annotation databases

EnsembliENST00000362063; ENSP00000354686; ENSG00000198740.
ENST00000430262; ENSP00000416305; ENSG00000198740.
GeneIDi22834.
KEGGihsa:22834.
UCSCiuc002iov.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023141 mRNA. Translation: BAA76768.2. Different initiation.
CR933680 mRNA. Translation: CAI45974.1.
CH471109 Genomic DNA. Translation: EAW94682.1.
BC139779 mRNA. Translation: AAI39780.1.
BC152440 mRNA. Translation: AAI52441.1.
CCDSiCCDS32677.1.
RefSeqiNP_001138837.1. NM_001145365.1.
NP_055712.1. NM_014897.2.
UniGeneiHs.463375.
Hs.712948.

3D structure databases

ProteinModelPortaliQ9Y2D9.
SMRiQ9Y2D9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9Y2D9. 4 interactors.
STRINGi9606.ENSP00000354686.

PTM databases

iPTMnetiQ9Y2D9.
PhosphoSitePlusiQ9Y2D9.

Polymorphism and mutation databases

BioMutaiZNF652.
DMDMi134035373.

Proteomic databases

EPDiQ9Y2D9.
MaxQBiQ9Y2D9.
PaxDbiQ9Y2D9.
PeptideAtlasiQ9Y2D9.
PRIDEiQ9Y2D9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000362063; ENSP00000354686; ENSG00000198740.
ENST00000430262; ENSP00000416305; ENSG00000198740.
GeneIDi22834.
KEGGihsa:22834.
UCSCiuc002iov.5. human.

Organism-specific databases

CTDi22834.
DisGeNETi22834.
GeneCardsiZNF652.
HGNCiHGNC:29147. ZNF652.
HPAiHPA044408.
MIMi613907. gene.
neXtProtiNX_Q9Y2D9.
OpenTargetsiENSG00000198740.
PharmGKBiPA134896615.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00440000037877.
HOGENOMiHOG000231037.
HOVERGENiHBG064823.
InParanoidiQ9Y2D9.
OMAiFYHGASQ.
OrthoDBiEOG091G055W.
PhylomeDBiQ9Y2D9.
TreeFamiTF332655.

Enzyme and pathway databases

BioCyciZFISH:G66-32282-MONOMER.

Miscellaneous databases

ChiTaRSiZNF652. human.
GenomeRNAii22834.
PROiQ9Y2D9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198740.
CleanExiHS_ZNF652.
ExpressionAtlasiQ9Y2D9. baseline and differential.
GenevisibleiQ9Y2D9. HS.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 9 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN652_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2D9
Secondary accession number(s): A4QPD9, Q5H9Q0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: November 2, 2016
This is version 126 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.