Reviewed, UniProtKB/Swiss-Prot Q9Y2D9 (ZN652_HUMAN)

Names and origin

Protein names

Recommended name:
    Zinc finger protein 652

Gene names

Name:	ZNF652
Synonyms:	KIAA0924

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	606 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Functions as a transcriptional repressor. Ref.6
Subunit structure	Interacts with CBFA2T3. Ref.6
Subcellular location	Nucleus Probable.
Tissue specificity	Widely expressed with higher expression in breast, prostate, vulva and pancreas. Ref.6
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 9 C2H2-type zinc fingers.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Repressor
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	regulation of transcription Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Ref.6 Inferred from physical interaction. Source: IntAct zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CBFA2T2	O43439	1	EBI-1190229,EBI-748628
CBFA2T3	O75081	1	EBI-1190229,EBI-1190217
RUNX1T1	Q06455	1	EBI-1190229,EBI-743342

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 606	606	Zinc finger protein 652		PRO_0000280428
Regions
	Zinc finger	245 – 268	24	C2H2-type 1
	Zinc finger	272 – 294	23	C2H2-type 2; degenerate
	Zinc finger	299 – 322	24	C2H2-type 3
	Zinc finger	329 – 351	23	C2H2-type 4
	Zinc finger	357 – 379	23	C2H2-type 5
	Zinc finger	385 – 407	23	C2H2-type 6
	Zinc finger	413 – 435	23	C2H2-type 7
	Zinc finger	441 – 463	23	C2H2-type 8
	Zinc finger	469 – 492	24	C2H2-type 9; degenerate
	Region	498 – 606	109	Mediates interaction with CBFA2T3
	Compositional bias	74 – 183	110	Glu-rich
	Compositional bias	497 – 574	78	Pro-rich
Amino acid modifications
	Modified residue	57	1	Phosphoserine Ref.9
	Modified residue	197	1	Phosphoserine Ref.9
	Modified residue	204	1	Phosphoserine Ref.9 Ref.7
	Modified residue	380	1	Phosphoserine Ref.8

Sequences

	Sequence		Length	Mass (Da)
	Q9Y2D9-1 [UniParc]. Last modified March 20, 2007. Version 3. Checksum: C066D10E179985CC	FASTA	606	69,744
	10 20 30 40 50 60 MSHTASSCQE LVENCAVHVA GMAQEDSRRG QVPSSFYHGA NQELDLSTKV YKRESGSPYS 70 80 90 100 110 120 VLVDTKMSKP HLHETEEQPY FRETRAVSDV HAVKEDRENS DDTEEEEEEV SYKREQIIVE 130 140 150 160 170 180 VNLNNQTLNV SKGEKGVSSQ SKETPVLKTS SEEEEEESEE EATDDSNDYG ENEKQKKKEK 190 200 210 220 230 240 IVEKVSVTQR RTRRAASVAA ATTSPTPRTT RGRRKSVEPP KRKKRATKEP KAPVQKAKCE 250 260 270 280 290 300 EKETLTCEKC PRVFNTRWYL EKHMNVTHRR MQICDKCGKK FVLESELSLH QQTDCEKNIQ 310 320 330 340 350 360 CVSCNKSFKK LWSLHEHIKI VHGYAEKKFS CEICEKKFYT MAHVRKHMVA HTKDMPFTCE 370 380 390 400 410 420 TCGKSFKRSM SLKVHSLQHS GEKPFRCENC DERFQYKYQL RSHMSIHIGH KQFMCQWCGK 430 440 450 460 470 480 DFNMKQYFDE HMKTHTGEKP FICEICGKSF TSRPNMKRHR RTHTGEKPYP CDVCGQRFRF 490 500 510 520 530 540 SNMLKAHKEK CFRVTSPVNV PPAVQIPLTT SPATPVPSVV NTATTPTPPI NMNPVSTLPP 550 560 570 580 590 600 RPIPHPFSHL HIHPHPHHPH HLPIPPVPHL PPPPALFKSE PLNHRGQSED NFLRHLAEKN SSAQHH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 6:63-70(1999) [PubMed: 10231032] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[2]	Ohara O., Nagase T., Kikuno R. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]	"ZNF652, a novel zinc finger protein, interacts with the putative breast tumor suppressor CBFA2T3 to repress transcription." Kumar R., Manning J., Spendlove H.E., Kremmidiotis G., McKirdy R., Lee J., Millband D.N., Cheney K.M., Stampfer M.R., Dwivedi P.P., Morris H.A., Callen D.F. Mol. Cancer Res. 4:655-665(2006) [PubMed: 16966434] [Abstract] Cited for: FUNCTION, INTERACTION WITH CBFA2T3, TISSUE SPECIFICITY.
[7]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-204, MASS SPECTROMETRY.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-380, MASS SPECTROMETRY.
[9]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-57; SER-197 AND SER-204, MASS SPECTROMETRY. Tissue: T-cell.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB023141 mRNA. Translation: BAA76768.2. Different initiation. CR933680 mRNA. Translation: CAI45974.1. CH471109 Genomic DNA. Translation: EAW94682.1. BC139779 mRNA. Translation: AAI39780.1. BC152440 mRNA. Translation: AAI52441.1.
IPI	IPI00790021.
RefSeq	NP_001138837.1. NP_055712.1.
UniGene	Hs.463375
3D structure databases
HSSP	HSSP built from PDB template 1SP2 based on UniProtKB P08047.
SMR	Q9Y2D9. Positions 296-465, 357-488.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y2D9. 3 interactions.
STRING	Q9Y2D9.
PTM databases
PhosphoSite	Q9Y2D9.
Proteomic databases
PRIDE	Q9Y2D9.
Genome annotation databases
Ensembl	ENST00000362063; ENSP00000354686; ENSG00000198740; Homo sapiens. [Genome view] ENST00000430262; ENSP00000416305; ENSG00000198740; Homo sapiens. [Genome view]
GeneID	22834.
KEGG	hsa:22834.
UCSC	uc002iov.2. human.
Organism-specific databases
CTD	22834.
GeneCards	GC17M044728.
HGNC	HGNC:29147. ZNF652.
PharmGKB	PA134896615.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG06773.
HOGENOM	HBG506587.
HOVERGEN	Q9Y2D9.
InParanoid	Q9Y2D9.
OMA	MAQEDSR.
OrthoDB	EOG99S8SG.
PhylomeDB	Q9Y2D9.
Gene expression databases
ArrayExpress	Q9Y2D9.
Bgee	Q9Y2D9.
CleanEx	HS_ZNF652.
Genevestigator	Q9Y2D9.
Family and domain databases
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Gene3D	G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 2 hits.
Pfam	PF00096. zf-C2H2. 2 hits. [Graphical view]
SMART	SM00355. ZnF_C2H2. 9 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 7 hits. PS50157. ZINC_FINGER_C2H2_2. 9 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	43261.

Entry information

Entry name

ZN652_HUMAN

Accession

Primary (citable) accession number: Q9Y2D9
Secondary accession number(s): A4QPD9, Q5H9Q0

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	March 20, 2007
Last modified:	January 19, 2010
This is version 67 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.