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Protein

A-kinase anchor protein 2

Gene

AKAP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
A-kinase anchor protein 2
Short name:
AKAP-2
Alternative name(s):
AKAP-KL
Protein kinase A-anchoring protein 2
Short name:
PRKA2
Gene namesi
Name:AKAP2
Synonyms:KIAA0920, PRKA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000241978.9
HGNCiHGNC:372 AKAP2
MIMi604582 gene
neXtProtiNX_Q9Y2D5

Pathology & Biotechi

Organism-specific databases

DisGeNETi11217
445815
OpenTargetsiENSG00000157654
ENSG00000241978
PharmGKBiPA162398639

Polymorphism and mutation databases

BioMutaiAKAP2
DMDMi254763433

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000645241 – 859A-kinase anchor protein 2Add BLAST859

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei91PhosphoserineCombined sources1
Modified residuei121PhosphoserineCombined sources1
Modified residuei152PhosphoserineCombined sources1
Cross-linki174Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki174Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei336PhosphoserineBy similarity1
Modified residuei393PhosphoserineCombined sources1
Modified residuei461PhosphoserineCombined sources1
Modified residuei465PhosphoserineBy similarity1
Modified residuei517PhosphoserineCombined sources1
Modified residuei526PhosphothreonineCombined sources1
Modified residuei631PhosphoserineCombined sources1
Modified residuei720PhosphoserineCombined sources1
Modified residuei748PhosphoserineCombined sources1
Modified residuei778PhosphoserineCombined sources1
Modified residuei785PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9Y2D5
PaxDbiQ9Y2D5
PeptideAtlasiQ9Y2D5
PRIDEiQ9Y2D5

PTM databases

iPTMnetiQ9Y2D5
PhosphoSitePlusiQ9Y2D5
SwissPalmiQ9Y2D5

Expressioni

Gene expression databases

BgeeiENSG00000241978
CleanExiHS_AKAP2
ExpressionAtlasiQ9Y2D5 baseline and differential
GenevisibleiQ9Y2D5 HS

Organism-specific databases

HPAiHPA058905

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116386, 40 interactors
138657, 7 interactors
IntActiQ9Y2D5, 35 interactors
STRINGi9606.ENSP00000451476

Structurei

3D structure databases

ProteinModelPortaliQ9Y2D5
SMRiQ9Y2D5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni566 – 579PKA-RII subunit binding domainAdd BLAST14

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili213 – 290Sequence analysisAdd BLAST78
Coiled coili710 – 748Sequence analysisAdd BLAST39

Domaini

The RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IG9A Eukaryota
ENOG410ZMFZ LUCA
GeneTreeiENSGT00530000063206
HOVERGENiHBG050477
InParanoidiQ9Y2D5
KOiK16519
OMAiQRPKNLM
OrthoDBiEOG091G012B
PhylomeDBiQ9Y2D5
TreeFamiTF105402

Family and domain databases

InterProiView protein in InterPro
IPR029304 AKAP2_C
PfamiView protein in Pfam
PF15304 AKAP2_C, 1 hit

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y2D5-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEIEVSVAEC KSVPGITSTP HPMDHPSAFY SPPHNGLLTD HHESLDNDVA
60 70 80 90 100
REIRYLDEVL EANCCDSAVD GTYNGTSSPE PGAVVLVGGL SPPVHEATQP
110 120 130 140 150
EPTERTASRQ APPHIELSNS SPDPMAEAER TNGHSPSQPR DALGDSLQVP
160 170 180 190 200
VSPSSTTSSR CSSRDGEFTL TTLKKEAKFE LRAFHEDKKP SKLFEDDEHE
210 220 230 240 250
KEQYCIRKVR PSEEMLELEK ERRELIRSQA VKKNPGIAAK WWNPPQEKTI
260 270 280 290 300
EEQLDEEHLE SHKKYKERKE RRAQQEQLLL QKQLQQQQQQ PPSQLCTAPA
310 320 330 340 350
SSHERASMID KAKEDIVTEQ IDFSAARKQF QLMENSRQAV AKGQSTPRLF
360 370 380 390 400
SIKPFYRPLG SVNSDKPLTN PRPPSVGGPP EDSGASAAKG QKSPGALETP
410 420 430 440 450
SAAGSQGNTA SQGKEGPYSE PSKRGPLSKL WAEDGEFTSA RAVLTVVKDD
460 470 480 490 500
DHGILDQFSR SVNVSLTQEE LDSGLDELSV RSQDTTVLET LSNDFSMDNI
510 520 530 540 550
SDSGASNETT NALQENSLAD FSLPQTPQTD NPSEGRGEGV SKSFSDHGFY
560 570 580 590 600
SPSSTLGDSP LVDDPLEYQA GLLVQNAIQQ AIAEQVDKAV SKTSRDGAEQ
610 620 630 640 650
QGPEATVEEA EAAAFGSEKP QSMFEPPQVS SPVQEKRDVL PKILPAEDRA
660 670 680 690 700
LRERGPPQPL PAVQPSGPIN MEETRPEGSY FSKYSEAAEL RSTASLLATQ
710 720 730 740 750
ESDVMVGPFK LRSRKQRTLS MIEEEIRAAQ EREEELKRQR QVLQSTQSPR
760 770 780 790 800
TKNAPSLPSR TCYKTAPGKI EKVKPPPSPT TEGPSLQPDL APEEAAGTQR
810 820 830 840 850
PKNLMQTLME DYETHKSKRR ERMDDSSVLE ATRVNRRKSA LALRWEAGIY

ANQEEEDNE
Length:859
Mass (Da):94,661
Last modified:July 28, 2009 - v3
Checksum:i6DCE563596DFBA4B
GO
Isoform 3 (identifier: Q9Y2D5-4) [UniParc]FASTAAdd to basket
Also known as: PALM2-AKAP2

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAEAELHKER...SSLSPDHKNM
     827-827: S → SYTSKLLSCKVTSE

Note: Based on a naturally occurring readthrough transcript which produces a PALM2-AKAP2 fusion protein.
Show »
Length:1,103
Mass (Da):122,071
Checksum:iB501182135112FE5
GO
Isoform 2 (identifier: Q9Y2D5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MRWPQPGAAA...SSLSPDHKNM

Show »
Length:948
Mass (Da):104,107
Checksum:i9DBF30D86F05F61F
GO
Isoform 4 (identifier: Q9Y2D5-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAEAELHKER...SSLSPDHKNM

Note: Based on a naturally occurring readthrough transcript which produces a PALM2-AKAP2 fusion protein.
Show »
Length:1,090
Mass (Da):120,630
Checksum:i51F5C843CC9C1A4C
GO
Isoform 5 (identifier: Q9Y2D5-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MRWPQPGAAA...SSLSPDHKNM
     827-827: S → SYTSKLLSCKVTSE

Show »
Length:961
Mass (Da):105,548
Checksum:iD2BF4A482F710D91
GO

Sequence cautioni

The sequence BAA76764 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti282K → Q in BAG51862 (PubMed:14702039).Curated1
Sequence conflicti282K → Q in BAG62154 (PubMed:14702039).Curated1
Sequence conflicti282K → Q in AAI46864 (PubMed:15489334).Curated1
Sequence conflicti282K → Q in AAI71800 (PubMed:15489334).Curated1
Sequence conflicti647E → G in CAB53707 (PubMed:17974005).Curated1
Sequence conflicti651L → P in BAG51862 (PubMed:14702039).Curated1
Sequence conflicti719L → S in BAG51862 (PubMed:14702039).Curated1
Isoform 2 (identifier: Q9Y2D5-5)
Sequence conflicti20P → L in AAI46864 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024248561L → S2 PublicationsCorresponds to variant dbSNP:rs914358Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0377701M → MRWPQPGAAARLPPESPGPP ESPGPPEREAAAARRWTGAE PQDCAPGSGRPEKPPQLSED DIWLKSEGDNYSATLLEPAA SSLSPDHKNM in isoform 2 and isoform 5. 2 Publications1
Alternative sequenceiVSP_0377691M → MAEAELHKERLQAIAEKRKR QTEIEGKRQQLDEQILLLQH SKSKVLREKWLLQGIPAGTA EEEEARRRQSEEDEFRVKQL EDNIQRLEQEIQTLESEESQ ISAKEQIILEKLKETEKSFK DFQKGFSSTDGDAVNYISSQ LPDLPILCSRTAEPSPGQDG TSRAAGVGWENVLLKEGESA SNATETSGPDMTIKKPPQLS EDDIWLKSEGDNYSATLLEP AASSLSPDHKNM in isoform 3 and isoform 4. 3 Publications1
Alternative sequenceiVSP_037771827S → SYTSKLLSCKVTSE in isoform 3 and isoform 5. 3 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ303079 mRNA Translation: CAC38839.1
AB023137 mRNA Translation: BAA76764.2 Different initiation.
AK057098 mRNA Translation: BAG51862.1
AK300427 mRNA Translation: BAG62154.1
AL627225
, AL158823, AL158829, AL353598, AL353806 Genomic DNA Translation: CAI10811.1
AL353806
, AL158823, AL158829, AL353598, AL627225 Genomic DNA Translation: CAI12434.1
AL158829
, AL158823, AL353598, AL353806, AL627225 Genomic DNA Translation: CAI13896.1
AL158823
, AL158829, AL353598, AL353806, AL627225 Genomic DNA Translation: CAI39560.1
AL353598
, AL158823, AL158829, AL353806, AL627225 Genomic DNA Translation: CAI40816.1
CH471105 Genomic DNA Translation: EAW59057.1
BC140818 mRNA Translation: AAI40819.1
BC146863 mRNA Translation: AAI46864.1
BC171800 mRNA Translation: AAI71800.1
AL110268 mRNA Translation: CAB53707.1
CCDSiCCDS43861.1 [Q9Y2D5-5]
CCDS48003.1 [Q9Y2D5-3]
CCDS56581.1 [Q9Y2D5-7]
PIRiT14787
RefSeqiNP_001004065.2, NM_001004065.4 [Q9Y2D5-5]
NP_001130034.1, NM_001136562.2 [Q9Y2D5-3]
NP_001185585.1, NM_001198656.1 [Q9Y2D5-7]
NP_009134.1, NM_007203.4 [Q9Y2D5-4]
NP_671492.1, NM_147150.2 [Q9Y2D5-6]
UniGeneiHs.591908

Genome annotation databases

EnsembliENST00000259318; ENSP00000259318; ENSG00000241978 [Q9Y2D5-3]
ENST00000374525; ENSP00000363649; ENSG00000241978 [Q9Y2D5-5]
ENST00000434623; ENSP00000404782; ENSG00000241978 [Q9Y2D5-7]
GeneIDi11217
445815
KEGGihsa:11217
hsa:445815
UCSCiuc004bem.4 human [Q9Y2D5-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiAKAP2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2D5
Secondary accession number(s): B1ALX9
, B2RTU4, B3KQ00, B4DTZ2, B7ZW07, B9EJB5, Q9UG26
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: July 28, 2009
Last modified: April 25, 2018
This is version 151 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health