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Protein

A-kinase anchor protein 2

Gene

AKAP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP (By similarity).By similarity

Enzyme and pathway databases

BioCyciZFISH:ENSG00000157654-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
A-kinase anchor protein 2
Short name:
AKAP-2
Alternative name(s):
AKAP-KL
Protein kinase A-anchoring protein 2
Short name:
PRKA2
Gene namesi
Name:AKAP2
Synonyms:KIAA0920, PRKA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:372. AKAP2.

Pathology & Biotechi

Organism-specific databases

DisGeNETi11217.
445815.
OpenTargetsiENSG00000157654.
ENSG00000241978.
PharmGKBiPA162398639.

Polymorphism and mutation databases

BioMutaiAKAP2.
DMDMi254763433.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000645241 – 859A-kinase anchor protein 2Add BLAST859

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei44PhosphoserineBy similarity1
Modified residuei91PhosphoserineCombined sources1
Modified residuei121PhosphoserineCombined sources1
Modified residuei152PhosphoserineCombined sources1
Cross-linki174Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Modified residuei336PhosphoserineBy similarity1
Modified residuei393PhosphoserineCombined sources1
Modified residuei461PhosphoserineCombined sources1
Modified residuei465PhosphoserineBy similarity1
Modified residuei473PhosphoserineBy similarity1
Modified residuei517PhosphoserineCombined sources1
Modified residuei526PhosphothreonineCombined sources1
Modified residuei631PhosphoserineCombined sources1
Modified residuei720PhosphoserineCombined sources1
Modified residuei748PhosphoserineCombined sources1
Modified residuei778PhosphoserineCombined sources1
Modified residuei785PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9Y2D5.
PaxDbiQ9Y2D5.
PeptideAtlasiQ9Y2D5.
PRIDEiQ9Y2D5.

PTM databases

iPTMnetiQ9Y2D5.
PhosphoSitePlusiQ9Y2D5.
SwissPalmiQ9Y2D5.

Expressioni

Gene expression databases

BgeeiENSG00000241978.
CleanExiHS_AKAP2.
ExpressionAtlasiQ9Y2D5. baseline and differential.
GenevisibleiQ9Y2D5. HS.

Organism-specific databases

HPAiHPA058905.

Interactioni

Protein-protein interaction databases

BioGridi116386. 37 interactors.
138657. 6 interactors.
IntActiQ9Y2D5. 33 interactors.
STRINGi9606.ENSP00000451476.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2D5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni566 – 579PKA-RII subunit binding domainAdd BLAST14

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili213 – 290Sequence analysisAdd BLAST78
Coiled coili710 – 748Sequence analysisAdd BLAST39

Domaini

The RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IG9A. Eukaryota.
ENOG410ZMFZ. LUCA.
GeneTreeiENSGT00530000063206.
HOVERGENiHBG050477.
InParanoidiQ9Y2D5.
KOiK16519.
OMAiVRPSEEM.
OrthoDBiEOG091G012B.
PhylomeDBiQ9Y2D5.
TreeFamiTF105402.

Family and domain databases

InterProiIPR029304. AKAP2_C.
[Graphical view]
PfamiPF15304. AKAP2_C. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y2D5-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEIEVSVAEC KSVPGITSTP HPMDHPSAFY SPPHNGLLTD HHESLDNDVA
60 70 80 90 100
REIRYLDEVL EANCCDSAVD GTYNGTSSPE PGAVVLVGGL SPPVHEATQP
110 120 130 140 150
EPTERTASRQ APPHIELSNS SPDPMAEAER TNGHSPSQPR DALGDSLQVP
160 170 180 190 200
VSPSSTTSSR CSSRDGEFTL TTLKKEAKFE LRAFHEDKKP SKLFEDDEHE
210 220 230 240 250
KEQYCIRKVR PSEEMLELEK ERRELIRSQA VKKNPGIAAK WWNPPQEKTI
260 270 280 290 300
EEQLDEEHLE SHKKYKERKE RRAQQEQLLL QKQLQQQQQQ PPSQLCTAPA
310 320 330 340 350
SSHERASMID KAKEDIVTEQ IDFSAARKQF QLMENSRQAV AKGQSTPRLF
360 370 380 390 400
SIKPFYRPLG SVNSDKPLTN PRPPSVGGPP EDSGASAAKG QKSPGALETP
410 420 430 440 450
SAAGSQGNTA SQGKEGPYSE PSKRGPLSKL WAEDGEFTSA RAVLTVVKDD
460 470 480 490 500
DHGILDQFSR SVNVSLTQEE LDSGLDELSV RSQDTTVLET LSNDFSMDNI
510 520 530 540 550
SDSGASNETT NALQENSLAD FSLPQTPQTD NPSEGRGEGV SKSFSDHGFY
560 570 580 590 600
SPSSTLGDSP LVDDPLEYQA GLLVQNAIQQ AIAEQVDKAV SKTSRDGAEQ
610 620 630 640 650
QGPEATVEEA EAAAFGSEKP QSMFEPPQVS SPVQEKRDVL PKILPAEDRA
660 670 680 690 700
LRERGPPQPL PAVQPSGPIN MEETRPEGSY FSKYSEAAEL RSTASLLATQ
710 720 730 740 750
ESDVMVGPFK LRSRKQRTLS MIEEEIRAAQ EREEELKRQR QVLQSTQSPR
760 770 780 790 800
TKNAPSLPSR TCYKTAPGKI EKVKPPPSPT TEGPSLQPDL APEEAAGTQR
810 820 830 840 850
PKNLMQTLME DYETHKSKRR ERMDDSSVLE ATRVNRRKSA LALRWEAGIY

ANQEEEDNE
Length:859
Mass (Da):94,661
Last modified:July 28, 2009 - v3
Checksum:i6DCE563596DFBA4B
GO
Isoform 2 (identifier: Q9Y2D5-4) [UniParc]FASTAAdd to basket
Also known as: PALM2-AKAP2

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAEAELHKER...SSLSPDHKNM
     827-827: S → SYTSKLLSCKVTSE

Note: Based on a naturally occurring readthrough transcript which produces a PALM2-AKAP2 fusion protein.
Show »
Length:1,103
Mass (Da):122,071
Checksum:iB501182135112FE5
GO
Isoform 3 (identifier: Q9Y2D5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MRWPQPGAAA...SSLSPDHKNM

Show »
Length:948
Mass (Da):104,107
Checksum:i9DBF30D86F05F61F
GO
Isoform 4 (identifier: Q9Y2D5-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAEAELHKER...SSLSPDHKNM

Note: Based on a naturally occurring readthrough transcript which produces a PALM2-AKAP2 fusion protein.
Show »
Length:1,090
Mass (Da):120,630
Checksum:i51F5C843CC9C1A4C
GO
Isoform 5 (identifier: Q9Y2D5-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MRWPQPGAAA...SSLSPDHKNM
     827-827: S → SYTSKLLSCKVTSE

Show »
Length:961
Mass (Da):105,548
Checksum:iD2BF4A482F710D91
GO

Sequence cautioni

The sequence BAA76764 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti282K → Q in BAG51862 (PubMed:14702039).Curated1
Sequence conflicti282K → Q in BAG62154 (PubMed:14702039).Curated1
Sequence conflicti282K → Q in AAI46864 (PubMed:15489334).Curated1
Sequence conflicti282K → Q in AAI71800 (PubMed:15489334).Curated1
Sequence conflicti647E → G in CAB53707 (PubMed:17974005).Curated1
Sequence conflicti651L → P in BAG51862 (PubMed:14702039).Curated1
Sequence conflicti719L → S in BAG51862 (PubMed:14702039).Curated1
Isoform 3 (identifier: Q9Y2D5-5)
Sequence conflicti20P → L in AAI46864 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024248561L → S.2 PublicationsCorresponds to variant rs914358dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0377691M → MAEAELHKERLQAIAEKRKR QTEIEGKRQQLDEQILLLQH SKSKVLREKWLLQGIPAGTA EEEEARRRQSEEDEFRVKQL EDNIQRLEQEIQTLESEESQ ISAKEQIILEKLKETEKSFK DFQKGFSSTDGDAVNYISSQ LPDLPILCSRTAEPSPGQDG TSRAAGVGWENVLLKEGESA SNATETSGPDMTIKKPPQLS EDDIWLKSEGDNYSATLLEP AASSLSPDHKNM in isoform 2 and isoform 4. 3 Publications1
Alternative sequenceiVSP_0377701M → MRWPQPGAAARLPPESPGPP ESPGPPEREAAAARRWTGAE PQDCAPGSGRPEKPPQLSED DIWLKSEGDNYSATLLEPAA SSLSPDHKNM in isoform 3 and isoform 5. 2 Publications1
Alternative sequenceiVSP_037771827S → SYTSKLLSCKVTSE in isoform 2 and isoform 5. 3 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ303079 mRNA. Translation: CAC38839.1.
AB023137 mRNA. Translation: BAA76764.2. Different initiation.
AK057098 mRNA. Translation: BAG51862.1.
AK300427 mRNA. Translation: BAG62154.1.
AL627225
, AL158823, AL158829, AL353598, AL353806 Genomic DNA. Translation: CAI10811.1.
AL353806
, AL158823, AL158829, AL353598, AL627225 Genomic DNA. Translation: CAI12434.1.
AL158829
, AL158823, AL353598, AL353806, AL627225 Genomic DNA. Translation: CAI13896.1.
AL158823
, AL158829, AL353598, AL353806, AL627225 Genomic DNA. Translation: CAI39560.1.
AL353598
, AL158823, AL158829, AL353806, AL627225 Genomic DNA. Translation: CAI40816.1.
CH471105 Genomic DNA. Translation: EAW59057.1.
BC140818 mRNA. Translation: AAI40819.1.
BC146863 mRNA. Translation: AAI46864.1.
BC171800 mRNA. Translation: AAI71800.1.
AL110268 mRNA. Translation: CAB53707.1.
CCDSiCCDS43861.1. [Q9Y2D5-5]
CCDS48003.1. [Q9Y2D5-3]
CCDS56581.1. [Q9Y2D5-7]
PIRiT14787.
RefSeqiNP_001004065.2. NM_001004065.4. [Q9Y2D5-5]
NP_001130034.1. NM_001136562.2. [Q9Y2D5-3]
NP_001185585.1. NM_001198656.1. [Q9Y2D5-7]
NP_009134.1. NM_007203.4. [Q9Y2D5-4]
NP_671492.1. NM_147150.2. [Q9Y2D5-6]
UniGeneiHs.591908.

Genome annotation databases

EnsembliENST00000259318; ENSP00000259318; ENSG00000241978. [Q9Y2D5-3]
ENST00000374525; ENSP00000363649; ENSG00000241978. [Q9Y2D5-5]
ENST00000434623; ENSP00000404782; ENSG00000241978. [Q9Y2D5-7]
GeneIDi11217.
445815.
KEGGihsa:11217.
hsa:445815.
UCSCiuc004bem.4. human. [Q9Y2D5-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ303079 mRNA. Translation: CAC38839.1.
AB023137 mRNA. Translation: BAA76764.2. Different initiation.
AK057098 mRNA. Translation: BAG51862.1.
AK300427 mRNA. Translation: BAG62154.1.
AL627225
, AL158823, AL158829, AL353598, AL353806 Genomic DNA. Translation: CAI10811.1.
AL353806
, AL158823, AL158829, AL353598, AL627225 Genomic DNA. Translation: CAI12434.1.
AL158829
, AL158823, AL353598, AL353806, AL627225 Genomic DNA. Translation: CAI13896.1.
AL158823
, AL158829, AL353598, AL353806, AL627225 Genomic DNA. Translation: CAI39560.1.
AL353598
, AL158823, AL158829, AL353806, AL627225 Genomic DNA. Translation: CAI40816.1.
CH471105 Genomic DNA. Translation: EAW59057.1.
BC140818 mRNA. Translation: AAI40819.1.
BC146863 mRNA. Translation: AAI46864.1.
BC171800 mRNA. Translation: AAI71800.1.
AL110268 mRNA. Translation: CAB53707.1.
CCDSiCCDS43861.1. [Q9Y2D5-5]
CCDS48003.1. [Q9Y2D5-3]
CCDS56581.1. [Q9Y2D5-7]
PIRiT14787.
RefSeqiNP_001004065.2. NM_001004065.4. [Q9Y2D5-5]
NP_001130034.1. NM_001136562.2. [Q9Y2D5-3]
NP_001185585.1. NM_001198656.1. [Q9Y2D5-7]
NP_009134.1. NM_007203.4. [Q9Y2D5-4]
NP_671492.1. NM_147150.2. [Q9Y2D5-6]
UniGeneiHs.591908.

3D structure databases

ProteinModelPortaliQ9Y2D5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116386. 37 interactors.
138657. 6 interactors.
IntActiQ9Y2D5. 33 interactors.
STRINGi9606.ENSP00000451476.

PTM databases

iPTMnetiQ9Y2D5.
PhosphoSitePlusiQ9Y2D5.
SwissPalmiQ9Y2D5.

Polymorphism and mutation databases

BioMutaiAKAP2.
DMDMi254763433.

Proteomic databases

EPDiQ9Y2D5.
PaxDbiQ9Y2D5.
PeptideAtlasiQ9Y2D5.
PRIDEiQ9Y2D5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259318; ENSP00000259318; ENSG00000241978. [Q9Y2D5-3]
ENST00000374525; ENSP00000363649; ENSG00000241978. [Q9Y2D5-5]
ENST00000434623; ENSP00000404782; ENSG00000241978. [Q9Y2D5-7]
GeneIDi11217.
445815.
KEGGihsa:11217.
hsa:445815.
UCSCiuc004bem.4. human. [Q9Y2D5-3]

Organism-specific databases

CTDi11217.
445815.
DisGeNETi11217.
445815.
GeneCardsiAKAP2.
HGNCiHGNC:372. AKAP2.
HPAiHPA058905.
MIMi604582. gene.
neXtProtiNX_Q9Y2D5.
OpenTargetsiENSG00000157654.
ENSG00000241978.
PharmGKBiPA162398639.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG9A. Eukaryota.
ENOG410ZMFZ. LUCA.
GeneTreeiENSGT00530000063206.
HOVERGENiHBG050477.
InParanoidiQ9Y2D5.
KOiK16519.
OMAiVRPSEEM.
OrthoDBiEOG091G012B.
PhylomeDBiQ9Y2D5.
TreeFamiTF105402.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000157654-MONOMER.

Miscellaneous databases

ChiTaRSiAKAP2. human.
GeneWikiiAKAP2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000241978.
CleanExiHS_AKAP2.
ExpressionAtlasiQ9Y2D5. baseline and differential.
GenevisibleiQ9Y2D5. HS.

Family and domain databases

InterProiIPR029304. AKAP2_C.
[Graphical view]
PfamiPF15304. AKAP2_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAKAP2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2D5
Secondary accession number(s): B1ALX9
, B2RTU4, B3KQ00, B4DTZ2, B7ZW07, B9EJB5, Q9UG26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: July 28, 2009
Last modified: November 30, 2016
This is version 139 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.