Q9Y2D5 (AKAP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
A-kinase anchor protein 2
Short name=AKAP-2

Alternative name(s):
AKAP-KL
Protein kinase A-anchoring protein 2
Short name=PRKA2

Gene names

Name:	AKAP2
Synonyms:	KIAA0920, PRKA2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	859 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP By similarity.
Domain	The RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.
Sequence caution	The sequence BAA76764.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	enzyme binding Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9Y2D5-3) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9Y2D5-4) Also known as: PALM2-AKAP2; The sequence of this isoform differs from the canonical sequence as follows:      1-1: M → MAEAELHKER...SSLSPDHKNM      827-827: S → SYTSKLLSCKVTSE
Note: Based on a naturally occurring readthrough transcript which produces a PALM2-AKAP2 fusion protein.
Isoform 3 (identifier: Q9Y2D5-5) The sequence of this isoform differs from the canonical sequence as follows:      1-1: M → MRWPQPGAAA...SSLSPDHKNM
Sequence annotation (Features)
	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
	Sequence conflict	20	1	P → L in AAI46864. Ref.6
Isoform 4 (identifier: Q9Y2D5-6) The sequence of this isoform differs from the canonical sequence as follows:      1-1: M → MAEAELHKER...SSLSPDHKNM
Note: Based on a naturally occurring readthrough transcript which produces a PALM2-AKAP2 fusion protein.
Isoform 5 (identifier: Q9Y2D5-7) The sequence of this isoform differs from the canonical sequence as follows:      1-1: M → MRWPQPGAAA...SSLSPDHKNM      827-827: S → SYTSKLLSCKVTSE

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 859	859	A-kinase anchor protein 2		PRO_0000064524
Regions
	Region	566 – 579	14	PKA-RII subunit binding domain
	Coiled coil	213 – 290	78	Potential
	Coiled coil	710 – 748	39	Potential
Amino acid modifications
	Modified residue	121	1	Phosphoserine Ref.12
	Modified residue	152	1	Phosphoserine Ref.9 Ref.12 Ref.13 Ref.14
	Modified residue	324	1	Phosphoserine Ref.14
	Modified residue	393	1	Phosphoserine Ref.11 Ref.12 Ref.14
	Modified residue	411	1	Phosphoserine Ref.13
	Modified residue	461	1	Phosphoserine Ref.14
	Modified residue	479	1	Phosphoserine Ref.14
	Modified residue	631	1	Phosphoserine Ref.12 Ref.13
	Modified residue	720	1	Phosphoserine Ref.9 Ref.11 Ref.12 Ref.14
	Modified residue	748	1	Phosphoserine Ref.10 Ref.12 Ref.14
	Modified residue	778	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	1	1	M → MAEAELHKERLQAIAEKRKR QTEIEGKRQQLDEQILLLQH SKSKVLREKWLLQGIPAGTA EEEEARRRQSEEDEFRVKQL EDNIQRLEQEIQTLESEESQ ISAKEQIILEKLKETEKSFK DFQKGFSSTDGDAVNYISSQ LPDLPILCSRTAEPSPGQDG TSRAAGVGWENVLLKEGESA SNATETSGPDMTIKKPPQLS EDDIWLKSEGDNYSATLLEP AASSLSPDHKNM in isoform 2 and isoform 4.		VSP_037769
	Alternative sequence	1	1	M → MRWPQPGAAARLPPESPGPP ESPGPPEREAAAARRWTGAE PQDCAPGSGRPEKPPQLSED DIWLKSEGDNYSATLLEPAA SSLSPDHKNM in isoform 3 and isoform 5.		VSP_037770
	Alternative sequence	827	1	S → SYTSKLLSCKVTSE in isoform 2 and isoform 5.		VSP_037771
	Natural variant	561	1	L → S. Ref.3 Ref.6 Corresponds to variant rs914358 [ dbSNP | Ensembl ].		VAR_024248
Experimental info
	Sequence conflict	282	1	K → Q in BAG51862. Ref.3
	Sequence conflict	282	1	K → Q in BAG62154. Ref.3
	Sequence conflict	282	1	K → Q in AAI46864. Ref.6
	Sequence conflict	282	1	K → Q in AAI71800. Ref.6
	Sequence conflict	647	1	E → G in CAB53707. Ref.7
	Sequence conflict	651	1	L → P in BAG51862. Ref.3
	Sequence conflict	719	1	L → S in BAG51862. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 28, 2009. Version 3. Checksum: 6DCE563596DFBA4B	FASTA	859	94,661
	10 20 30 40 50 60 MEIEVSVAEC KSVPGITSTP HPMDHPSAFY SPPHNGLLTD HHESLDNDVA REIRYLDEVL 70 80 90 100 110 120 EANCCDSAVD GTYNGTSSPE PGAVVLVGGL SPPVHEATQP EPTERTASRQ APPHIELSNS 130 140 150 160 170 180 SPDPMAEAER TNGHSPSQPR DALGDSLQVP VSPSSTTSSR CSSRDGEFTL TTLKKEAKFE 190 200 210 220 230 240 LRAFHEDKKP SKLFEDDEHE KEQYCIRKVR PSEEMLELEK ERRELIRSQA VKKNPGIAAK 250 260 270 280 290 300 WWNPPQEKTI EEQLDEEHLE SHKKYKERKE RRAQQEQLLL QKQLQQQQQQ PPSQLCTAPA 310 320 330 340 350 360 SSHERASMID KAKEDIVTEQ IDFSAARKQF QLMENSRQAV AKGQSTPRLF SIKPFYRPLG 370 380 390 400 410 420 SVNSDKPLTN PRPPSVGGPP EDSGASAAKG QKSPGALETP SAAGSQGNTA SQGKEGPYSE 430 440 450 460 470 480 PSKRGPLSKL WAEDGEFTSA RAVLTVVKDD DHGILDQFSR SVNVSLTQEE LDSGLDELSV 490 500 510 520 530 540 RSQDTTVLET LSNDFSMDNI SDSGASNETT NALQENSLAD FSLPQTPQTD NPSEGRGEGV 550 560 570 580 590 600 SKSFSDHGFY SPSSTLGDSP LVDDPLEYQA GLLVQNAIQQ AIAEQVDKAV SKTSRDGAEQ 610 620 630 640 650 660 QGPEATVEEA EAAAFGSEKP QSMFEPPQVS SPVQEKRDVL PKILPAEDRA LRERGPPQPL 670 680 690 700 710 720 PAVQPSGPIN MEETRPEGSY FSKYSEAAEL RSTASLLATQ ESDVMVGPFK LRSRKQRTLS 730 740 750 760 770 780 MIEEEIRAAQ EREEELKRQR QVLQSTQSPR TKNAPSLPSR TCYKTAPGKI EKVKPPPSPT 790 800 810 820 830 840 TEGPSLQPDL APEEAAGTQR PKNLMQTLME DYETHKSKRR ERMDDSSVLE ATRVNRRKSA 850 LALRWEAGIY ANQEEEDNE
	Isoform 2 (PALM2-AKAP2) [UniParc]. Checksum: B501182135112FE5	FASTA	1,103	122,071
	10 20 30 40 50 60 MAEAELHKER LQAIAEKRKR QTEIEGKRQQ LDEQILLLQH SKSKVLREKW LLQGIPAGTA 70 80 90 100 110 120 EEEEARRRQS EEDEFRVKQL EDNIQRLEQE IQTLESEESQ ISAKEQIILE KLKETEKSFK 130 140 150 160 170 180 DFQKGFSSTD GDAVNYISSQ LPDLPILCSR TAEPSPGQDG TSRAAGVGWE NVLLKEGESA 190 200 210 220 230 240 SNATETSGPD MTIKKPPQLS EDDIWLKSEG DNYSATLLEP AASSLSPDHK NMEIEVSVAE 250 260 270 280 290 300 CKSVPGITST PHPMDHPSAF YSPPHNGLLT DHHESLDNDV AREIRYLDEV LEANCCDSAV 310 320 330 340 350 360 DGTYNGTSSP EPGAVVLVGG LSPPVHEATQ PEPTERTASR QAPPHIELSN SSPDPMAEAE 370 380 390 400 410 420 RTNGHSPSQP RDALGDSLQV PVSPSSTTSS RCSSRDGEFT LTTLKKEAKF ELRAFHEDKK 430 440 450 460 470 480 PSKLFEDDEH EKEQYCIRKV RPSEEMLELE KERRELIRSQ AVKKNPGIAA KWWNPPQEKT 490 500 510 520 530 540 IEEQLDEEHL ESHKKYKERK ERRAQQEQLL LQKQLQQQQQ QPPSQLCTAP ASSHERASMI 550 560 570 580 590 600 DKAKEDIVTE QIDFSAARKQ FQLMENSRQA VAKGQSTPRL FSIKPFYRPL GSVNSDKPLT 610 620 630 640 650 660 NPRPPSVGGP PEDSGASAAK GQKSPGALET PSAAGSQGNT ASQGKEGPYS EPSKRGPLSK 670 680 690 700 710 720 LWAEDGEFTS ARAVLTVVKD DDHGILDQFS RSVNVSLTQE ELDSGLDELS VRSQDTTVLE 730 740 750 760 770 780 TLSNDFSMDN ISDSGASNET TNALQENSLA DFSLPQTPQT DNPSEGRGEG VSKSFSDHGF 790 800 810 820 830 840 YSPSSTLGDS PLVDDPLEYQ AGLLVQNAIQ QAIAEQVDKA VSKTSRDGAE QQGPEATVEE 850 860 870 880 890 900 AEAAAFGSEK PQSMFEPPQV SSPVQEKRDV LPKILPAEDR ALRERGPPQP LPAVQPSGPI 910 920 930 940 950 960 NMEETRPEGS YFSKYSEAAE LRSTASLLAT QESDVMVGPF KLRSRKQRTL SMIEEEIRAA 970 980 990 1000 1010 1020 QEREEELKRQ RQVLQSTQSP RTKNAPSLPS RTCYKTAPGK IEKVKPPPSP TTEGPSLQPD 1030 1040 1050 1060 1070 1080 LAPEEAAGTQ RPKNLMQTLM EDYETHKSKR RERMDDSSYT SKLLSCKVTS EVLEATRVNR 1090 1100 RKSALALRWE AGIYANQEEE DNE
	Isoform 3 [UniParc]. Checksum: 9DBF30D86F05F61F	FASTA	948	104,107
	10 20 30 40 50 60 MRWPQPGAAA RLPPESPGPP ESPGPPEREA AAARRWTGAE PQDCAPGSGR PEKPPQLSED 70 80 90 100 110 120 DIWLKSEGDN YSATLLEPAA SSLSPDHKNM EIEVSVAECK SVPGITSTPH PMDHPSAFYS 130 140 150 160 170 180 PPHNGLLTDH HESLDNDVAR EIRYLDEVLE ANCCDSAVDG TYNGTSSPEP GAVVLVGGLS 190 200 210 220 230 240 PPVHEATQPE PTERTASRQA PPHIELSNSS PDPMAEAERT NGHSPSQPRD ALGDSLQVPV 250 260 270 280 290 300 SPSSTTSSRC SSRDGEFTLT TLKKEAKFEL RAFHEDKKPS KLFEDDEHEK EQYCIRKVRP 310 320 330 340 350 360 SEEMLELEKE RRELIRSQAV KKNPGIAAKW WNPPQEKTIE EQLDEEHLES HKKYKERKER 370 380 390 400 410 420 RAQQEQLLLQ KQLQQQQQQP PSQLCTAPAS SHERASMIDK AKEDIVTEQI DFSAARKQFQ 430 440 450 460 470 480 LMENSRQAVA KGQSTPRLFS IKPFYRPLGS VNSDKPLTNP RPPSVGGPPE DSGASAAKGQ 490 500 510 520 530 540 KSPGALETPS AAGSQGNTAS QGKEGPYSEP SKRGPLSKLW AEDGEFTSAR AVLTVVKDDD 550 560 570 580 590 600 HGILDQFSRS VNVSLTQEEL DSGLDELSVR SQDTTVLETL SNDFSMDNIS DSGASNETTN 610 620 630 640 650 660 ALQENSLADF SLPQTPQTDN PSEGRGEGVS KSFSDHGFYS PSSTLGDSPL VDDPLEYQAG 670 680 690 700 710 720 LLVQNAIQQA IAEQVDKAVS KTSRDGAEQQ GPEATVEEAE AAAFGSEKPQ SMFEPPQVSS 730 740 750 760 770 780 PVQEKRDVLP KILPAEDRAL RERGPPQPLP AVQPSGPINM EETRPEGSYF SKYSEAAELR 790 800 810 820 830 840 STASLLATQE SDVMVGPFKL RSRKQRTLSM IEEEIRAAQE REEELKRQRQ VLQSTQSPRT 850 860 870 880 890 900 KNAPSLPSRT CYKTAPGKIE KVKPPPSPTT EGPSLQPDLA PEEAAGTQRP KNLMQTLMED 910 920 930 940 YETHKSKRRE RMDDSSVLEA TRVNRRKSAL ALRWEAGIYA NQEEEDNE
	Isoform 4 [UniParc]. Checksum: 51F5C843CC9C1A4C	FASTA	1,090	120,630
	10 20 30 40 50 60 MAEAELHKER LQAIAEKRKR QTEIEGKRQQ LDEQILLLQH SKSKVLREKW LLQGIPAGTA 70 80 90 100 110 120 EEEEARRRQS EEDEFRVKQL EDNIQRLEQE IQTLESEESQ ISAKEQIILE KLKETEKSFK 130 140 150 160 170 180 DFQKGFSSTD GDAVNYISSQ LPDLPILCSR TAEPSPGQDG TSRAAGVGWE NVLLKEGESA 190 200 210 220 230 240 SNATETSGPD MTIKKPPQLS EDDIWLKSEG DNYSATLLEP AASSLSPDHK NMEIEVSVAE 250 260 270 280 290 300 CKSVPGITST PHPMDHPSAF YSPPHNGLLT DHHESLDNDV AREIRYLDEV LEANCCDSAV 310 320 330 340 350 360 DGTYNGTSSP EPGAVVLVGG LSPPVHEATQ PEPTERTASR QAPPHIELSN SSPDPMAEAE 370 380 390 400 410 420 RTNGHSPSQP RDALGDSLQV PVSPSSTTSS RCSSRDGEFT LTTLKKEAKF ELRAFHEDKK 430 440 450 460 470 480 PSKLFEDDEH EKEQYCIRKV RPSEEMLELE KERRELIRSQ AVKKNPGIAA KWWNPPQEKT 490 500 510 520 530 540 IEEQLDEEHL ESHKKYKERK ERRAQQEQLL LQKQLQQQQQ QPPSQLCTAP ASSHERASMI 550 560 570 580 590 600 DKAKEDIVTE QIDFSAARKQ FQLMENSRQA VAKGQSTPRL FSIKPFYRPL GSVNSDKPLT 610 620 630 640 650 660 NPRPPSVGGP PEDSGASAAK GQKSPGALET PSAAGSQGNT ASQGKEGPYS EPSKRGPLSK 670 680 690 700 710 720 LWAEDGEFTS ARAVLTVVKD DDHGILDQFS RSVNVSLTQE ELDSGLDELS VRSQDTTVLE 730 740 750 760 770 780 TLSNDFSMDN ISDSGASNET TNALQENSLA DFSLPQTPQT DNPSEGRGEG VSKSFSDHGF 790 800 810 820 830 840 YSPSSTLGDS PLVDDPLEYQ AGLLVQNAIQ QAIAEQVDKA VSKTSRDGAE QQGPEATVEE 850 860 870 880 890 900 AEAAAFGSEK PQSMFEPPQV SSPVQEKRDV LPKILPAEDR ALRERGPPQP LPAVQPSGPI 910 920 930 940 950 960 NMEETRPEGS YFSKYSEAAE LRSTASLLAT QESDVMVGPF KLRSRKQRTL SMIEEEIRAA 970 980 990 1000 1010 1020 QEREEELKRQ RQVLQSTQSP RTKNAPSLPS RTCYKTAPGK IEKVKPPPSP TTEGPSLQPD 1030 1040 1050 1060 1070 1080 LAPEEAAGTQ RPKNLMQTLM EDYETHKSKR RERMDDSSVL EATRVNRRKS ALALRWEAGI 1090 YANQEEEDNE
	Isoform 5 [UniParc]. Checksum: D2BF4A482F710D91	FASTA	961	105,548
	10 20 30 40 50 60 MRWPQPGAAA RLPPESPGPP ESPGPPEREA AAARRWTGAE PQDCAPGSGR PEKPPQLSED 70 80 90 100 110 120 DIWLKSEGDN YSATLLEPAA SSLSPDHKNM EIEVSVAECK SVPGITSTPH PMDHPSAFYS 130 140 150 160 170 180 PPHNGLLTDH HESLDNDVAR EIRYLDEVLE ANCCDSAVDG TYNGTSSPEP GAVVLVGGLS 190 200 210 220 230 240 PPVHEATQPE PTERTASRQA PPHIELSNSS PDPMAEAERT NGHSPSQPRD ALGDSLQVPV 250 260 270 280 290 300 SPSSTTSSRC SSRDGEFTLT TLKKEAKFEL RAFHEDKKPS KLFEDDEHEK EQYCIRKVRP 310 320 330 340 350 360 SEEMLELEKE RRELIRSQAV KKNPGIAAKW WNPPQEKTIE EQLDEEHLES HKKYKERKER 370 380 390 400 410 420 RAQQEQLLLQ KQLQQQQQQP PSQLCTAPAS SHERASMIDK AKEDIVTEQI DFSAARKQFQ 430 440 450 460 470 480 LMENSRQAVA KGQSTPRLFS IKPFYRPLGS VNSDKPLTNP RPPSVGGPPE DSGASAAKGQ 490 500 510 520 530 540 KSPGALETPS AAGSQGNTAS QGKEGPYSEP SKRGPLSKLW AEDGEFTSAR AVLTVVKDDD 550 560 570 580 590 600 HGILDQFSRS VNVSLTQEEL DSGLDELSVR SQDTTVLETL SNDFSMDNIS DSGASNETTN 610 620 630 640 650 660 ALQENSLADF SLPQTPQTDN PSEGRGEGVS KSFSDHGFYS PSSTLGDSPL VDDPLEYQAG 670 680 690 700 710 720 LLVQNAIQQA IAEQVDKAVS KTSRDGAEQQ GPEATVEEAE AAAFGSEKPQ SMFEPPQVSS 730 740 750 760 770 780 PVQEKRDVLP KILPAEDRAL RERGPPQPLP AVQPSGPINM EETRPEGSYF SKYSEAAELR 790 800 810 820 830 840 STASLLATQE SDVMVGPFKL RSRKQRTLSM IEEEIRAAQE REEELKRQRQ VLQSTQSPRT 850 860 870 880 890 900 KNAPSLPSRT CYKTAPGKIE KVKPPPSPTT EGPSLQPDLA PEEAAGTQRP KNLMQTLMED 910 920 930 940 950 960 YETHKSKRRE RMDDSSYTSK LLSCKVTSEV LEATRVNRRK SALALRWEAG IYANQEEEDN E

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Homo sapiens AKAP-2 complete cDNA sequence." Schuetze N., Reichel S., Ruecker N., Lechner A., Eulert J., Jakob F. Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]	"Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 6:63-70(1999) [PubMed: 10231032] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT SER-561. Tissue: Placenta and Small intestine.
[4]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed: 15164053] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 4 AND 5), VARIANT SER-561. Tissue: Brain.
[7]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 539-859 (ISOFORMS 1/3/4). Tissue: Brain.
[8]	"The paralemmin protein family: identification of paralemmin-2, an isoform differentially spliced to AKAP2/AKAP-KL, and of palmdelphin, a more distant cytosolic relative." Hu B., Copeland N.G., Gilbert D.J., Jenkins N.A., Kilimann M.W. Biochem. Biophys. Res. Commun. 285:1369-1376(2001) [PubMed: 11478809] [Abstract] Cited for: ALTERNATIVE SPLICING (ISOFORM 3). Tissue: Muscle.
[9]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-152 AND SER-720, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis." Wang B., Malik R., Nigg E.A., Korner R. Anal. Chem. 80:9526-9533(2008) [PubMed: 19007248] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-748, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-393 AND SER-720, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-121; SER-152; SER-393; SER-631; SER-720 AND SER-748, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[13]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-152; SER-411 AND SER-631, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[14]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-152; SER-324; SER-393; SER-461; SER-479; SER-720 AND SER-748, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ303079 mRNA. Translation: CAC38839.1. AB023137 mRNA. Translation: BAA76764.2. Different initiation. AK057098 mRNA. Translation: BAG51862.1. AK300427 mRNA. Translation: BAG62154.1. AL627225 , AL158823, AL158829, AL353598, AL353806 Genomic DNA. Translation: CAI10811.1. AL353806 , AL158823, AL158829, AL353598, AL627225 Genomic DNA. Translation: CAI12434.1. AL158829 , AL158823, AL353598, AL353806, AL627225 Genomic DNA. Translation: CAI13896.1. AL158823 , AL158829, AL353598, AL353806, AL627225 Genomic DNA. Translation: CAI39560.1. AL353598 , AL158823, AL158829, AL353806, AL627225 Genomic DNA. Translation: CAI40816.1. CH471105 Genomic DNA. Translation: EAW59057.1. BC140818 mRNA. Translation: AAI40819.1. BC146863 mRNA. Translation: AAI46864.1. BC171800 mRNA. Translation: AAI71800.1. AL110268 mRNA. Translation: CAB53707.1.
IPI	IPI00032064. IPI00171217. IPI00816415. IPI00914995. IPI00942356.
PIR	T14787.
RefSeq	NP_001004065.2. NM_001004065.4. NP_001130034.1. NM_001136562.2. NP_001185585.1. NM_001198656.1. NP_009134.1. NM_007203.4. NP_671492.1. NM_147150.2.
UniGene	Hs.591908.
3D structure databases
ProteinModelPortal	Q9Y2D5.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y2D5. 8 interactions.
STRING	Q9Y2D5.
Polymorphism databases
DMDM	254763433.
Proteomic databases
PRIDE	Q9Y2D5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000259318; ENSP00000259318; ENSG00000241978. ENST00000302798; ENSP00000305861; ENSG00000157654. ENST00000374525; ENSP00000363649; ENSG00000241978.
GeneID	11217. 445815.
KEGG	hsa:11217. hsa:445815.
UCSC	uc004bei.2. human. uc004bej.2. human.
Organism-specific databases
CTD	11217. 445815.
GeneCards	GC09P112542. GC09P112810.
H-InvDB	HIX0008274.
HGNC	HGNC:372. AKAP2.
MIM	604582. gene.
neXtProt	NX_Q9Y2D5.
PharmGKB	PA162398639.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00530000063206.
HOVERGEN	HBG050477.
InParanoid	Q9Y2D5.
OMA	MENSRQT.
Gene expression databases
ArrayExpress	Q9Y2D5.
CleanEx	HS_AKAP2.
Genevestigator	Q9Y2D5.
GermOnline	ENSG00000157654. Homo sapiens.
Family and domain databases
InterPro	IPR018459. RII_binding_1. [Graphical view]
Pfam	PF10522. RII_binding_1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	111405.
SOURCE	Search...

Entry information

Entry name

AKAP2_HUMAN

Accession

Primary (citable) accession number: Q9Y2D5
Secondary accession number(s): B1ALX9 , B2RTU4, B3KQ00, B4DTZ2, B7ZW07, B9EJB5, Q9UG26

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
Last sequence update:	July 28, 2009
Last modified:	January 25, 2012
This is version 91 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.