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Protein

Exocyst complex component 6B

Gene

EXOC6B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Exocytosis, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Exocyst complex component 6B
Alternative name(s):
Exocyst complex component Sec15B
SEC15-like protein 2
Gene namesi
Name:EXOC6B
Synonyms:KIAA0919, SEC15B, SEC15L2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:17085. EXOC6B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162385463.

Polymorphism and mutation databases

BioMutaiEXOC6B.
DMDMi327478583.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 811811Exocyst complex component 6BPRO_0000118954Add
BLAST

Proteomic databases

EPDiQ9Y2D4.
MaxQBiQ9Y2D4.
PaxDbiQ9Y2D4.
PRIDEiQ9Y2D4.

PTM databases

iPTMnetiQ9Y2D4.
PhosphoSiteiQ9Y2D4.

Expressioni

Gene expression databases

BgeeiQ9Y2D4.
CleanExiHS_EXOC6B.
ExpressionAtlasiQ9Y2D4. baseline and differential.
GenevisibleiQ9Y2D4. HS.

Organism-specific databases

HPAiHPA063991.

Interactioni

Subunit structurei

The exocyst complex is composed of SEC3, SEC5, SEC6, SEC8, SEC10, SEC15, EXO70 and EXO84.

Protein-protein interaction databases

BioGridi116838. 13 interactions.
IntActiQ9Y2D4. 1 interaction.
STRINGi9606.ENSP00000272427.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2D4.
SMRiQ9Y2D4. Positions 420-738.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili50 – 11970Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the SEC15 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2176. Eukaryota.
ENOG410XQAE. LUCA.
GeneTreeiENSGT00390000005739.
HOGENOMiHOG000290640.
HOVERGENiHBG057543.
InParanoidiQ9Y2D4.
KOiK19985.
OMAiVKQISMG.
OrthoDBiEOG7MD4PG.
PhylomeDBiQ9Y2D4.
TreeFamiTF315199.

Family and domain databases

InterProiIPR007225. Sec15.
[Graphical view]
PANTHERiPTHR12702. PTHR12702. 1 hit.
PfamiPF04091. Sec15. 1 hit.
[Graphical view]
PIRSFiPIRSF025007. Sec15. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y2D4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MERGKMAEAE SLETAAEHER ILREIESTDT ACIGPTLRSV YDGEEHGRFM
60 70 80 90 100
EKLETRIRNH DREIEKMCNF HYQGFVDSIT ELLKVRGEAQ KLKNQVTDTN
110 120 130 140 150
RKLQHEGKEL VIAMEELKQC RLQQRNISAT VDKLMLCLPV LEMYSKLRDQ
160 170 180 190 200
MKTKRHYPAL KTLEHLEHTY LPQVSHYRFC KVMVDNIPKL REEIKDVSMS
210 220 230 240 250
DLKDFLESIR KHSDKIGETA MKQAQQQRNL DNIVLQQPRI GSKRKSKKDA
260 270 280 290 300
YIIFDTEIES TSPKSEQDSG ILDVEDEEDD EEVPGAQDLV DFSPVYRCLH
310 320 330 340 350
IYSVLGARET FENYYRKQRR KQARLVLQPP SNMHETLDGY RKYFNQIVGF
360 370 380 390 400
FVVEDHILHT TQGLVNRAYI DELWEMALSK TIAALRTHSS YCSDPNLVLD
410 420 430 440 450
LKNLIVLFAD TLQVYGFPVN QLFDMLLEIR DQYSETLLKK WAGIFRNILD
460 470 480 490 500
SDNYSPIPVT SEEMYKKVVG QFPFQDIELE KQPFPKKFPF SEFVPKVYNQ
510 520 530 540 550
IKEFIYACLK FSEDLHLSST EVDDMIRKST NLLLTRTLSN SLQNVIKRKN
560 570 580 590 600
IGLTELVQII INTTHLEKSC KYLEEFITNI TNVLPETVHT TKLYGTTTFK
610 620 630 640 650
DARHAAEEEI YTNLNQKIDQ FLQLADYDWM TGDLGNKASD YLVDLIAFLR
660 670 680 690 700
STFAVFTHLP GKVAQTACMS ACKHLATSLM QLLLEAEVRQ LTLGALQQFN
710 720 730 740 750
LDVRECEQFA RSGPVPGFQE DTLQLAFIDL RQLLDLFIQW DWSTYLADYG
760 770 780 790 800
QPNCKYLRVN PVTALTLLEK MKDTSRKNNM FAQFRKNERD KQKLIDTVAK
810
QLRGLISSHH S
Length:811
Mass (Da):94,201
Last modified:April 5, 2011 - v3
Checksum:iA666EC6A0B82D9A2
GO
Isoform 2 (identifier: Q9Y2D4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     661-672: GKVAQTACMSAC → VSGSCSYFVLYI
     673-811: Missing.

Show »
Length:672
Mass (Da):78,234
Checksum:i887F48FFE59B94D1
GO

Sequence cautioni

The sequence BAA76763.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei661 – 67212GKVAQ…CMSAC → VSGSCSYFVLYI in isoform 2. 1 PublicationVSP_040838Add
BLAST
Alternative sequencei673 – 811139Missing in isoform 2. 1 PublicationVSP_040839Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023136 mRNA. Translation: BAA76763.1. Different initiation.
AC006461 Genomic DNA. No translation available.
AC016770 Genomic DNA. No translation available.
AC092630 Genomic DNA. No translation available.
AC104309 Genomic DNA. No translation available.
AC105051 Genomic DNA. No translation available.
BC160001 mRNA. No translation available.
CCDSiCCDS46333.1. [Q9Y2D4-1]
RefSeqiNP_056004.1. NM_015189.1. [Q9Y2D4-1]
UniGeneiHs.303454.

Genome annotation databases

EnsembliENST00000272427; ENSP00000272427; ENSG00000144036. [Q9Y2D4-1]
GeneIDi23233.
KEGGihsa:23233.
UCSCiuc010fep.4. human. [Q9Y2D4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023136 mRNA. Translation: BAA76763.1. Different initiation.
AC006461 Genomic DNA. No translation available.
AC016770 Genomic DNA. No translation available.
AC092630 Genomic DNA. No translation available.
AC104309 Genomic DNA. No translation available.
AC105051 Genomic DNA. No translation available.
BC160001 mRNA. No translation available.
CCDSiCCDS46333.1. [Q9Y2D4-1]
RefSeqiNP_056004.1. NM_015189.1. [Q9Y2D4-1]
UniGeneiHs.303454.

3D structure databases

ProteinModelPortaliQ9Y2D4.
SMRiQ9Y2D4. Positions 420-738.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116838. 13 interactions.
IntActiQ9Y2D4. 1 interaction.
STRINGi9606.ENSP00000272427.

PTM databases

iPTMnetiQ9Y2D4.
PhosphoSiteiQ9Y2D4.

Polymorphism and mutation databases

BioMutaiEXOC6B.
DMDMi327478583.

Proteomic databases

EPDiQ9Y2D4.
MaxQBiQ9Y2D4.
PaxDbiQ9Y2D4.
PRIDEiQ9Y2D4.

Protocols and materials databases

DNASUi23233.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000272427; ENSP00000272427; ENSG00000144036. [Q9Y2D4-1]
GeneIDi23233.
KEGGihsa:23233.
UCSCiuc010fep.4. human. [Q9Y2D4-1]

Organism-specific databases

CTDi23233.
GeneCardsiEXOC6B.
H-InvDBHIX0002154.
HGNCiHGNC:17085. EXOC6B.
HPAiHPA063991.
MIMi607880. gene.
neXtProtiNX_Q9Y2D4.
PharmGKBiPA162385463.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2176. Eukaryota.
ENOG410XQAE. LUCA.
GeneTreeiENSGT00390000005739.
HOGENOMiHOG000290640.
HOVERGENiHBG057543.
InParanoidiQ9Y2D4.
KOiK19985.
OMAiVKQISMG.
OrthoDBiEOG7MD4PG.
PhylomeDBiQ9Y2D4.
TreeFamiTF315199.

Miscellaneous databases

ChiTaRSiEXOC6B. human.
GenomeRNAii23233.
NextBioi44866.
PROiQ9Y2D4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y2D4.
CleanExiHS_EXOC6B.
ExpressionAtlasiQ9Y2D4. baseline and differential.
GenevisibleiQ9Y2D4. HS.

Family and domain databases

InterProiIPR007225. Sec15.
[Graphical view]
PANTHERiPTHR12702. PTHR12702. 1 hit.
PfamiPF04091. Sec15. 1 hit.
[Graphical view]
PIRSFiPIRSF025007. Sec15. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "The brain exocyst complex interacts with RalA in a GTP-dependent manner: identification of a novel mammalian Sec3 gene and a second Sec15 gene."
    Brymora A., Valova V.A., Larsen M.R., Roufogalis B.D., Robinson P.J.
    J. Biol. Chem. 276:29792-29797(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION AS EXOC6B.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiEXC6B_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2D4
Secondary accession number(s): B8ZZY3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: April 5, 2011
Last modified: May 11, 2016
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.