Q9Y2D2 (S35A3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UDP-N-acetylglucosamine transporter

Alternative name(s):
Golgi UDP-GlcNAc transporter
Solute carrier family 35 member A3

Gene names

Name:

SLC35A3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	325 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Uridine diphosphate-N-acetylglucosamine transporter in the Golgi apparatus.
Subcellular location	Golgi apparatus membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.

Ontologies

Keywords
Biological process	Sugar transport Transport
Cellular component	Golgi apparatus Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	UDP-N-acetylglucosamine metabolic process Traceable author statement Ref.1. Source: ProtInc
Cellular_component	Golgi membrane Traceable author statement. Source: Reactome integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	UDP-N-acetylglucosamine transmembrane transporter activity Traceable author statement Ref.1. Source: ProtInc sugar:hydrogen symporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9Y2D2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Y2D2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSSRSVLSPVVGTDAPDQHLELKKPQELKEMERLPLANEDKT

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 325	325	UDP-N-acetylglucosamine transporter		PRO_0000213357
Regions
	Transmembrane	8 – 24	17	Helical; Potential
	Transmembrane	42 – 58	17	Helical; Potential
	Transmembrane	138 – 154	17	Helical; Potential
	Transmembrane	173 – 189	17	Helical; Potential
	Transmembrane	209 – 225	17	Helical; Potential
	Transmembrane	246 – 262	17	Helical; Potential
	Transmembrane	268 – 284	17	Helical; Potential
	Transmembrane	295 – 311	17	Helical; Potential
Natural variations
	Alternative sequence	1	1	M → MSSRSVLSPVVGTDAPDQHL ELKKPQELKEMERLPLANED KT in isoform 2.		VSP_012786

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 69DFD944E37206C8	FASTA	325	35,985
	10 20 30 40 50 60 MFANLKYVSL GILVFQTTSL VLTMRYSRTL KEEGPRYLSS TAVVVAELLK IMACILLVYK 70 80 90 100 110 120 DSKCSLRALN RVLHDEILNK PMETLKLAIP SGIYTLQNNL LYVALSNLDA ATYQVTYQLK 130 140 150 160 170 180 ILTTALFSVS MLSKKLGVYQ WLSLVILMTG VAFVQWPSDS QLDSKELSAG SQFVGLMAVL 190 200 210 220 230 240 TACFSSGFAG VYFEKILKET KQSVWIRNIQ LGFFGSIFGL MGVYIYDGEL VSKNGFFQGY 250 260 270 280 290 300 NRLTWIVVVL QALGGLVIAA VIKYADNILK GFATSLSIIL STLISYFWLQ DFVPTSVFFL 310 320 GAILVITATF LYGYDPKPAG NPTKA
	Isoform 2 [UniParc]. Checksum: F623CA177EABFBF4	FASTA	366	40,554
	10 20 30 40 50 60 MSSRSVLSPV VGTDAPDQHL ELKKPQELKE MERLPLANED KTFANLKYVS LGILVFQTTS 70 80 90 100 110 120 LVLTMRYSRT LKEEGPRYLS STAVVVAELL KIMACILLVY KDSKCSLRAL NRVLHDEILN 130 140 150 160 170 180 KPMETLKLAI PSGIYTLQNN LLYVALSNLD AATYQVTYQL KILTTALFSV SMLSKKLGVY 190 200 210 220 230 240 QWLSLVILMT GVAFVQWPSD SQLDSKELSA GSQFVGLMAV LTACFSSGFA GVYFEKILKE 250 260 270 280 290 300 TKQSVWIRNI QLGFFGSIFG LMGVYIYDGE LVSKNGFFQG YNRLTWIVVV LQALGGLVIA 310 320 330 340 350 360 AVIKYADNIL KGFATSLSII LSTLISYFWL QDFVPTSVFF LGAILVITAT FLYGYDPKPA GNPTKA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and functional expression of the human Golgi UDP-N-acetylglucosamine transporter." Ishida N., Yoshioka S., Chiba Y., Takeuchi M., Kawakita M. J. Biochem. 126:68-77(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Colon carcinoma.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Web resources

GGDB

GlycoGene database

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB021981 mRNA. Translation: BAA77841.1. AK290573 mRNA. Translation: BAF83262.1. CR749816 mRNA. Translation: CAH18676.1. CH471097 Genomic DNA. Translation: EAW72978.1. CH471097 Genomic DNA. Translation: EAW72979.1.
IPI	IPI00470810. IPI01011468.
RefSeq	NP_001258613.1. NM_001271684.1. NP_001258614.1. NM_001271685.1. NP_036375.1. NM_012243.2.
UniGene	Hs.448979. Hs.534953.
3D structure databases
ProteinModelPortal	Q9Y2D2.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y2D2. 2 interactions.
MINT	MINT-4781806.
STRING	9606.ENSP00000359174.
Protein family/group databases
TCDB	2.A.7.12.7. drug/metabolite transporter (DMT) superfamily.
PTM databases
PhosphoSite	Q9Y2D2.
Polymorphism databases
DMDM	9087207.
Proteomic databases
PaxDb	Q9Y2D2.
PRIDE	Q9Y2D2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000370153; ENSP00000359172; ENSG00000117620. ENST00000370155; ENSP00000359174; ENSG00000117620. ENST00000427993; ENSP00000414947; ENSG00000117620. ENST00000533028; ENSP00000433849; ENSG00000117620.
GeneID	23443.
KEGG	hsa:23443.
UCSC	uc001dsp.1. human. uc001dsr.1. human.
Organism-specific databases
CTD	23443.
GeneCards	GC01P100435.
HGNC	HGNC:11023. SLC35A3.
HPA	HPA015253.
MIM	605632. gene.
neXtProt	NX_Q9Y2D2.
PharmGKB	PA35891.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0697.
HOGENOM	HOG000216649.
HOVERGEN	HBG054025.
InParanoid	Q9Y2D2.
KO	K15272.
OrthoDB	EOG4V9TR3.
PhylomeDB	Q9Y2D2.
Enzyme and pathway databases
Reactome	REACT_15518. Transmembrane transport of small molecules.
Gene expression databases
ArrayExpress	Q9Y2D2.
Bgee	Q9Y2D2.
CleanEx	HS_SLC35A3.
Genevestigator	Q9Y2D2.
GermOnline	ENSG00000117620. Homo sapiens.
Family and domain databases
InterPro	IPR007271. Nuc_sug_transpt. IPR021189. UDP/CMP-sugar_transptr. IPR004689. UDPgal_transpt. [Graphical view]
PANTHER	PTHR10231. PTHR10231. 1 hit.
Pfam	PF04142. Nuc_sug_transp. 1 hit. [Graphical view]
PIRSF	PIRSF005799. UDP-gal_transpt. 1 hit.
TIGRFAMs	TIGR00803. nst. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	SLC35A3. human.
GenomeRNAi	23443.
NextBio	45719.
SOURCE	Search...

Entry information

Entry name

S35A3_HUMAN

Accession

Primary (citable) accession number: Q9Y2D2
Secondary accession number(s): A8K3F8, D3DT54, Q68CR2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	November 1, 1999
Last modified:	May 29, 2013
This is version 104 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.