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Q9Y2D1 (ATF5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 129. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cyclic AMP-dependent transcription factor ATF-5

Short name=cAMP-dependent transcription factor ATF-5
Alternative name(s):
Activating transcription factor 5
Transcription factor ATFx
Gene names
Name:ATF5
Synonyms:ATFX
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length282 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcriptional activator which binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters and blocks the differentiation of neuroprogenitor cells into neurons. Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4. Ref.8 Ref.9

Subunit structure

Binds DNA as a dimer. Interacts with PTP4A1/PRL-1 By similarity. Interacts with CCND3, but not with CCND1 or CCND2. Interacts with CDC34. Ref.8 Ref.9

Subcellular location

Cytoplasm. Nucleus Ref.9.

Post-translational modification

Ubiquitinated by CDC34 and UBE2B in order to be degraded by the proteasome. Ref.8

Sequence similarities

Belongs to the bZIP family.

Contains 1 bZIP (basic-leucine zipper) domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentCytoplasm
Nucleus
   Coding sequence diversityPolymorphism
   LigandDNA-binding
   Molecular functionActivator
   PTMUbl conjugation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmulticellular organism growth

Inferred from electronic annotation. Source: Ensembl

negative regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of astrocyte differentiation

Inferred from electronic annotation. Source: Ensembl

olfactory bulb interneuron development

Inferred from electronic annotation. Source: Ensembl

post-embryonic development

Inferred from electronic annotation. Source: Ensembl

regulation of transcription from RNA polymerase II promoter

Traceable author statement Ref.8. Source: ProtInc

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from direct assay. Source: HPA

nucleus

Inferred from direct assay. Source: HPA

transcription factor complex

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionprotein binding

Inferred from physical interaction Ref.8. Source: UniProtKB

sequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

transcription corepressor activity

Traceable author statement Ref.8. Source: ProtInc

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

DISC1Q9NRI58EBI-492509,EBI-529989

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 282282Cyclic AMP-dependent transcription factor ATF-5
PRO_0000076586

Regions

Domain208 – 27164bZIP
Region119 – 21799Interaction with PTP4A1 By similarity
Region210 – 23021Basic motif By similarity
Region236 – 25015Leucine-zipper By similarity
Compositional bias123 – 13917Poly-Pro
Compositional bias186 – 1949Poly-Pro

Natural variations

Natural variant1211P → L. Ref.2 Ref.7
Corresponds to variant rs283526 [ dbSNP | Ensembl ].
VAR_022786

Experimental info

Sequence conflict161 – 1633LLA → RHE in AAD28370. Ref.8

Sequences

Sequence LengthMass (Da)Tools
Q9Y2D1 [UniParc].

Last modified October 5, 2010. Version 4.
Checksum: DDB2F907CA0215A0

FASTA28230,674
        10         20         30         40         50         60 
MSLLATLGLE LDRALLPASG LGWLVDYGKL PPAPAPLAPY EVLGGALEGG LPVGGEPLAG 

        70         80         90        100        110        120 
DGFSDWMTER VDFTALLPLE PPLPPGTLPQ PSPTPPDLEA MASLLKKELE QMEDFFLDAP 

       130        140        150        160        170        180 
PLPPPSPPPL PPPPLPPAPS LPLSLPSFDL PQPPVLDTLD LLAIYCRNEA GQEEVGMPPL 

       190        200        210        220        230        240 
PPPQQPPPPS PPQPSRLAPY PHPATTRGDR KQKKRDQNKS AALRYRQRKR AEGEALEGEC 

       250        260        270        280 
QGLEARNREL KERAESVERE IQYVKDLLIE VYKARSQRTR SC 

« Hide

References

« Hide 'large scale' references
[1]"The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx."
White J.H., McIllhinney R.A.J., Wise A., Ciruela F., Chan W.-Y., Emson P.C., Billinton A., Marshall F.H.
Proc. Natl. Acad. Sci. U.S.A. 97:13967-13972(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas."
Yamada S., Ohira M., Horie H., Ando K., Takayasu H., Suzuki Y., Sugano S., Hirata T., Goto T., Matsunaga T., Hiyama E., Hayashi Y., Ando H., Suita S., Kaneko M., Sasaki F., Hashizume K., Ohnuma N., Nakagawara A.
Oncogene 23:5901-5911(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT LEU-121.
Tissue: Hepatoblastoma.
[3]"cDNA clone encoding leucine-zipper protein."
Kohroki J., Tanaka K.
Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-121.
Tissue: Placenta.
[8]"Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis."
Pati D., Meistrich M.L., Plon S.E.
Mol. Cell. Biol. 19:5001-5013(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 161-282, FUNCTION, INTERACTION WITH CDC34, UBIQUITINATION.
[9]"Cyclin D3 interacts with human activating transcription factor 5 and potentiates its transcription activity."
Liu W., Sun M., Jiang J., Shen X., Sun Q., Liu W., Shen H., Gu J.
Biochem. Biophys. Res. Commun. 321:954-960(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH CCND3, FUNCTION, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF305687 mRNA. Translation: AAG22558.1.
AB073613 mRNA. Translation: BAD38650.1.
AB021663 mRNA. Translation: BAA78477.2.
AK024402 mRNA. Translation: BAG51295.1.
AC011452 Genomic DNA. No translation available.
CH471177 Genomic DNA. Translation: EAW52581.1.
BC005174 mRNA. Translation: AAH05174.1.
AF101388 mRNA. Translation: AAD28370.1.
CCDSCCDS12789.1.
RefSeqNP_001180575.1. NM_001193646.1.
NP_001277675.1. NM_001290746.1.
NP_036200.2. NM_012068.5.
UniGeneHs.9754.

3D structure databases

ProteinModelPortalQ9Y2D1.
SMRQ9Y2D1. Positions 216-271.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116487. 13 interactions.
IntActQ9Y2D1. 6 interactions.
STRING9606.ENSP00000307356.

PTM databases

PhosphoSiteQ9Y2D1.

Polymorphism databases

DMDM308153647.

Proteomic databases

PRIDEQ9Y2D1.

Protocols and materials databases

DNASU22809.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000423777; ENSP00000396954; ENSG00000169136.
ENST00000595125; ENSP00000470633; ENSG00000169136.
GeneID22809.
KEGGhsa:22809.
UCSCuc002prd.3. human.

Organism-specific databases

CTD22809.
GeneCardsGC19P050431.
H-InvDBHIX0015352.
HGNCHGNC:790. ATF5.
HPAHPA030187.
MIM606398. gene.
neXtProtNX_Q9Y2D1.
PharmGKBPA25090.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG273999.
HOGENOMHOG000004844.
HOVERGENHBG003535.
InParanoidQ9Y2D1.
KOK09044.
OMATFDLPQP.
PhylomeDBQ9Y2D1.
TreeFamTF316136.

Gene expression databases

ArrayExpressQ9Y2D1.
BgeeQ9Y2D1.
CleanExHS_ATF5.
GenevestigatorQ9Y2D1.

Family and domain databases

InterProIPR004827. bZIP.
[Graphical view]
PfamPF00170. bZIP_1. 1 hit.
[Graphical view]
SMARTSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEPS50217. BZIP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSATF5. human.
GeneWikiATF5.
GenomeRNAi22809.
NextBio43190.
PROQ9Y2D1.
SOURCESearch...

Entry information

Entry nameATF5_HUMAN
AccessionPrimary (citable) accession number: Q9Y2D1
Secondary accession number(s): B3KND3, Q9BSA1, Q9UNQ3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 5, 2010
Last modified: July 9, 2014
This is version 129 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM