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Protein

Cyclic AMP-dependent transcription factor ATF-5

Gene

ATF5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional activator which binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters and blocks the differentiation of neuroprogenitor cells into neurons. Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4.2 Publications

GO - Molecular functioni

  1. RNA polymerase II regulatory region sequence-specific DNA binding Source: NTNU_SB
  2. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
  3. transcription corepressor activity Source: ProtInc

GO - Biological processi

  1. multicellular organism growth Source: Ensembl
  2. negative regulation of apoptotic process Source: Ensembl
  3. negative regulation of astrocyte differentiation Source: Ensembl
  4. negative regulation of nucleic acid-templated transcription Source: GOC
  5. olfactory bulb interneuron development Source: Ensembl
  6. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  7. post-embryonic development Source: Ensembl
  8. regulation of transcription from RNA polymerase II promoter Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic AMP-dependent transcription factor ATF-5
Short name:
cAMP-dependent transcription factor ATF-5
Alternative name(s):
Activating transcription factor 5
Transcription factor ATFx
Gene namesi
Name:ATF5
Synonyms:ATFX
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:790. ATF5.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus 1 PublicationPROSITE-ProRule annotation

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. nucleoplasm Source: HPA
  3. transcription factor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25090.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 282282Cyclic AMP-dependent transcription factor ATF-5PRO_0000076586Add
BLAST

Post-translational modificationi

Ubiquitinated by CDC34 and UBE2B in order to be degraded by the proteasome.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

PRIDEiQ9Y2D1.

PTM databases

PhosphoSiteiQ9Y2D1.

Expressioni

Gene expression databases

BgeeiQ9Y2D1.
CleanExiHS_ATF5.
ExpressionAtlasiQ9Y2D1. baseline and differential.
GenevestigatoriQ9Y2D1.

Organism-specific databases

HPAiHPA030187.

Interactioni

Subunit structurei

Binds DNA as a dimer. Interacts with PTP4A1/PRL-1 (By similarity). Interacts with CCND3, but not with CCND1 or CCND2. Interacts with CDC34.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
DISC1Q9NRI58EBI-492509,EBI-529989

Protein-protein interaction databases

BioGridi116487. 12 interactions.
IntActiQ9Y2D1. 7 interactions.
STRINGi9606.ENSP00000307356.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2D1.
SMRiQ9Y2D1. Positions 216-271.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini208 – 27164bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni119 – 21799Interaction with PTP4A1By similarityAdd
BLAST
Regioni210 – 23021Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni236 – 25015Leucine-zipperPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi123 – 13917Poly-ProAdd
BLAST
Compositional biasi186 – 1949Poly-Pro

Sequence similaritiesi

Belongs to the bZIP family.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG273999.
GeneTreeiENSGT00530000063801.
HOGENOMiHOG000004844.
HOVERGENiHBG003535.
InParanoidiQ9Y2D1.
KOiK09044.
OMAiTFDLPQP.
PhylomeDBiQ9Y2D1.
TreeFamiTF316136.

Family and domain databases

InterProiIPR029855. ATF-5.
IPR004827. bZIP.
[Graphical view]
PANTHERiPTHR13044:SF3. PTHR13044:SF3. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y2D1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLLATLGLE LDRALLPASG LGWLVDYGKL PPAPAPLAPY EVLGGALEGG
60 70 80 90 100
LPVGGEPLAG DGFSDWMTER VDFTALLPLE PPLPPGTLPQ PSPTPPDLEA
110 120 130 140 150
MASLLKKELE QMEDFFLDAP PLPPPSPPPL PPPPLPPAPS LPLSLPSFDL
160 170 180 190 200
PQPPVLDTLD LLAIYCRNEA GQEEVGMPPL PPPQQPPPPS PPQPSRLAPY
210 220 230 240 250
PHPATTRGDR KQKKRDQNKS AALRYRQRKR AEGEALEGEC QGLEARNREL
260 270 280
KERAESVERE IQYVKDLLIE VYKARSQRTR SC
Length:282
Mass (Da):30,674
Last modified:October 5, 2010 - v4
Checksum:iDDB2F907CA0215A0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti161 – 1633LLA → RHE in AAD28370. (PubMed:10373550)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti121 – 1211P → L.2 Publications
Corresponds to variant rs283526 [ dbSNP | Ensembl ].
VAR_022786

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF305687 mRNA. Translation: AAG22558.1.
AB073613 mRNA. Translation: BAD38650.1.
AB021663 mRNA. Translation: BAA78477.2.
AK024402 mRNA. Translation: BAG51295.1.
AC011452 Genomic DNA. No translation available.
CH471177 Genomic DNA. Translation: EAW52581.1.
BC005174 mRNA. Translation: AAH05174.1.
AF101388 mRNA. Translation: AAD28370.1.
CCDSiCCDS12789.1.
RefSeqiNP_001180575.1. NM_001193646.1.
NP_001277675.1. NM_001290746.1.
NP_036200.2. NM_012068.5.
UniGeneiHs.9754.

Genome annotation databases

EnsembliENST00000423777; ENSP00000396954; ENSG00000169136.
ENST00000595125; ENSP00000470633; ENSG00000169136.
GeneIDi22809.
KEGGihsa:22809.
UCSCiuc002prd.3. human.

Polymorphism databases

DMDMi308153647.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF305687 mRNA. Translation: AAG22558.1.
AB073613 mRNA. Translation: BAD38650.1.
AB021663 mRNA. Translation: BAA78477.2.
AK024402 mRNA. Translation: BAG51295.1.
AC011452 Genomic DNA. No translation available.
CH471177 Genomic DNA. Translation: EAW52581.1.
BC005174 mRNA. Translation: AAH05174.1.
AF101388 mRNA. Translation: AAD28370.1.
CCDSiCCDS12789.1.
RefSeqiNP_001180575.1. NM_001193646.1.
NP_001277675.1. NM_001290746.1.
NP_036200.2. NM_012068.5.
UniGeneiHs.9754.

3D structure databases

ProteinModelPortaliQ9Y2D1.
SMRiQ9Y2D1. Positions 216-271.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116487. 12 interactions.
IntActiQ9Y2D1. 7 interactions.
STRINGi9606.ENSP00000307356.

Chemistry

DrugBankiDB00852. Pseudoephedrine.

PTM databases

PhosphoSiteiQ9Y2D1.

Polymorphism databases

DMDMi308153647.

Proteomic databases

PRIDEiQ9Y2D1.

Protocols and materials databases

DNASUi22809.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000423777; ENSP00000396954; ENSG00000169136.
ENST00000595125; ENSP00000470633; ENSG00000169136.
GeneIDi22809.
KEGGihsa:22809.
UCSCiuc002prd.3. human.

Organism-specific databases

CTDi22809.
GeneCardsiGC19P050431.
H-InvDBHIX0015352.
HGNCiHGNC:790. ATF5.
HPAiHPA030187.
MIMi606398. gene.
neXtProtiNX_Q9Y2D1.
PharmGKBiPA25090.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG273999.
GeneTreeiENSGT00530000063801.
HOGENOMiHOG000004844.
HOVERGENiHBG003535.
InParanoidiQ9Y2D1.
KOiK09044.
OMAiTFDLPQP.
PhylomeDBiQ9Y2D1.
TreeFamiTF316136.

Miscellaneous databases

ChiTaRSiATF5. human.
GeneWikiiATF5.
GenomeRNAii22809.
NextBioi43190.
PROiQ9Y2D1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y2D1.
CleanExiHS_ATF5.
ExpressionAtlasiQ9Y2D1. baseline and differential.
GenevestigatoriQ9Y2D1.

Family and domain databases

InterProiIPR029855. ATF-5.
IPR004827. bZIP.
[Graphical view]
PANTHERiPTHR13044:SF3. PTHR13044:SF3. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx."
    White J.H., McIllhinney R.A.J., Wise A., Ciruela F., Chan W.-Y., Emson P.C., Billinton A., Marshall F.H.
    Proc. Natl. Acad. Sci. U.S.A. 97:13967-13972(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas."
    Yamada S., Ohira M., Horie H., Ando K., Takayasu H., Suzuki Y., Sugano S., Hirata T., Goto T., Matsunaga T., Hiyama E., Hayashi Y., Ando H., Suita S., Kaneko M., Sasaki F., Hashizume K., Ohnuma N., Nakagawara A.
    Oncogene 23:5901-5911(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT LEU-121.
    Tissue: Hepatoblastoma.
  3. "cDNA clone encoding leucine-zipper protein."
    Kohroki J., Tanaka K.
    Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-121.
    Tissue: Placenta.
  8. "Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis."
    Pati D., Meistrich M.L., Plon S.E.
    Mol. Cell. Biol. 19:5001-5013(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 161-282, FUNCTION, INTERACTION WITH CDC34, UBIQUITINATION.
  9. "Cyclin D3 interacts with human activating transcription factor 5 and potentiates its transcription activity."
    Liu W., Sun M., Jiang J., Shen X., Sun Q., Liu W., Shen H., Gu J.
    Biochem. Biophys. Res. Commun. 321:954-960(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CCND3, FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiATF5_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2D1
Secondary accession number(s): B3KND3, Q9BSA1, Q9UNQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 5, 2010
Last modified: February 4, 2015
This is version 133 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.