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Q9Y2D1

- ATF5_HUMAN

UniProt

Q9Y2D1 - ATF5_HUMAN

Protein

Cyclic AMP-dependent transcription factor ATF-5

Gene

ATF5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 4 (05 Oct 2010)
      Previous versions | rss
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    Functioni

    Transcriptional activator which binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters and blocks the differentiation of neuroprogenitor cells into neurons. Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4.2 Publications

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. RNA polymerase II regulatory region sequence-specific DNA binding Source: NTNU_SB
    3. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
    4. transcription corepressor activity Source: ProtInc

    GO - Biological processi

    1. multicellular organism growth Source: Ensembl
    2. negative regulation of apoptotic process Source: Ensembl
    3. negative regulation of astrocyte differentiation Source: Ensembl
    4. olfactory bulb interneuron development Source: Ensembl
    5. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
    6. post-embryonic development Source: Ensembl
    7. regulation of transcription from RNA polymerase II promoter Source: ProtInc

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclic AMP-dependent transcription factor ATF-5
    Short name:
    cAMP-dependent transcription factor ATF-5
    Alternative name(s):
    Activating transcription factor 5
    Transcription factor ATFx
    Gene namesi
    Name:ATF5
    Synonyms:ATFX
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:790. ATF5.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 PublicationPROSITE-ProRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. nucleus Source: HPA
    3. transcription factor complex Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25090.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 282282Cyclic AMP-dependent transcription factor ATF-5PRO_0000076586Add
    BLAST

    Post-translational modificationi

    Ubiquitinated by CDC34 and UBE2B in order to be degraded by the proteasome.1 Publication

    Keywords - PTMi

    Ubl conjugation

    Proteomic databases

    PRIDEiQ9Y2D1.

    PTM databases

    PhosphoSiteiQ9Y2D1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Y2D1.
    BgeeiQ9Y2D1.
    CleanExiHS_ATF5.
    GenevestigatoriQ9Y2D1.

    Organism-specific databases

    HPAiHPA030187.

    Interactioni

    Subunit structurei

    Binds DNA as a dimer. Interacts with PTP4A1/PRL-1 By similarity. Interacts with CCND3, but not with CCND1 or CCND2. Interacts with CDC34.By similarity2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    DISC1Q9NRI58EBI-492509,EBI-529989

    Protein-protein interaction databases

    BioGridi116487. 13 interactions.
    IntActiQ9Y2D1. 6 interactions.
    STRINGi9606.ENSP00000307356.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y2D1.
    SMRiQ9Y2D1. Positions 216-271.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini208 – 27164bZIPPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni119 – 21799Interaction with PTP4A1By similarityAdd
    BLAST
    Regioni210 – 23021Basic motifPROSITE-ProRule annotationAdd
    BLAST
    Regioni236 – 25015Leucine-zipperPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi123 – 13917Poly-ProAdd
    BLAST
    Compositional biasi186 – 1949Poly-Pro

    Sequence similaritiesi

    Belongs to the bZIP family.Curated
    Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG273999.
    HOGENOMiHOG000004844.
    HOVERGENiHBG003535.
    InParanoidiQ9Y2D1.
    KOiK09044.
    OMAiTFDLPQP.
    PhylomeDBiQ9Y2D1.
    TreeFamiTF316136.

    Family and domain databases

    InterProiIPR004827. bZIP.
    [Graphical view]
    PfamiPF00170. bZIP_1. 1 hit.
    [Graphical view]
    SMARTiSM00338. BRLZ. 1 hit.
    [Graphical view]
    PROSITEiPS50217. BZIP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Y2D1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLLATLGLE LDRALLPASG LGWLVDYGKL PPAPAPLAPY EVLGGALEGG    50
    LPVGGEPLAG DGFSDWMTER VDFTALLPLE PPLPPGTLPQ PSPTPPDLEA 100
    MASLLKKELE QMEDFFLDAP PLPPPSPPPL PPPPLPPAPS LPLSLPSFDL 150
    PQPPVLDTLD LLAIYCRNEA GQEEVGMPPL PPPQQPPPPS PPQPSRLAPY 200
    PHPATTRGDR KQKKRDQNKS AALRYRQRKR AEGEALEGEC QGLEARNREL 250
    KERAESVERE IQYVKDLLIE VYKARSQRTR SC 282
    Length:282
    Mass (Da):30,674
    Last modified:October 5, 2010 - v4
    Checksum:iDDB2F907CA0215A0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti161 – 1633LLA → RHE in AAD28370. (PubMed:10373550)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti121 – 1211P → L.2 Publications
    Corresponds to variant rs283526 [ dbSNP | Ensembl ].
    VAR_022786

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF305687 mRNA. Translation: AAG22558.1.
    AB073613 mRNA. Translation: BAD38650.1.
    AB021663 mRNA. Translation: BAA78477.2.
    AK024402 mRNA. Translation: BAG51295.1.
    AC011452 Genomic DNA. No translation available.
    CH471177 Genomic DNA. Translation: EAW52581.1.
    BC005174 mRNA. Translation: AAH05174.1.
    AF101388 mRNA. Translation: AAD28370.1.
    CCDSiCCDS12789.1.
    RefSeqiNP_001180575.1. NM_001193646.1.
    NP_001277675.1. NM_001290746.1.
    NP_036200.2. NM_012068.5.
    UniGeneiHs.9754.

    Genome annotation databases

    EnsembliENST00000423777; ENSP00000396954; ENSG00000169136.
    ENST00000595125; ENSP00000470633; ENSG00000169136.
    GeneIDi22809.
    KEGGihsa:22809.
    UCSCiuc002prd.3. human.

    Polymorphism databases

    DMDMi308153647.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF305687 mRNA. Translation: AAG22558.1 .
    AB073613 mRNA. Translation: BAD38650.1 .
    AB021663 mRNA. Translation: BAA78477.2 .
    AK024402 mRNA. Translation: BAG51295.1 .
    AC011452 Genomic DNA. No translation available.
    CH471177 Genomic DNA. Translation: EAW52581.1 .
    BC005174 mRNA. Translation: AAH05174.1 .
    AF101388 mRNA. Translation: AAD28370.1 .
    CCDSi CCDS12789.1.
    RefSeqi NP_001180575.1. NM_001193646.1.
    NP_001277675.1. NM_001290746.1.
    NP_036200.2. NM_012068.5.
    UniGenei Hs.9754.

    3D structure databases

    ProteinModelPortali Q9Y2D1.
    SMRi Q9Y2D1. Positions 216-271.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116487. 13 interactions.
    IntActi Q9Y2D1. 6 interactions.
    STRINGi 9606.ENSP00000307356.

    Chemistry

    DrugBanki DB00852. Pseudoephedrine.

    PTM databases

    PhosphoSitei Q9Y2D1.

    Polymorphism databases

    DMDMi 308153647.

    Proteomic databases

    PRIDEi Q9Y2D1.

    Protocols and materials databases

    DNASUi 22809.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000423777 ; ENSP00000396954 ; ENSG00000169136 .
    ENST00000595125 ; ENSP00000470633 ; ENSG00000169136 .
    GeneIDi 22809.
    KEGGi hsa:22809.
    UCSCi uc002prd.3. human.

    Organism-specific databases

    CTDi 22809.
    GeneCardsi GC19P050431.
    H-InvDB HIX0015352.
    HGNCi HGNC:790. ATF5.
    HPAi HPA030187.
    MIMi 606398. gene.
    neXtProti NX_Q9Y2D1.
    PharmGKBi PA25090.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG273999.
    HOGENOMi HOG000004844.
    HOVERGENi HBG003535.
    InParanoidi Q9Y2D1.
    KOi K09044.
    OMAi TFDLPQP.
    PhylomeDBi Q9Y2D1.
    TreeFami TF316136.

    Miscellaneous databases

    ChiTaRSi ATF5. human.
    GeneWikii ATF5.
    GenomeRNAii 22809.
    NextBioi 43190.
    PROi Q9Y2D1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y2D1.
    Bgeei Q9Y2D1.
    CleanExi HS_ATF5.
    Genevestigatori Q9Y2D1.

    Family and domain databases

    InterProi IPR004827. bZIP.
    [Graphical view ]
    Pfami PF00170. bZIP_1. 1 hit.
    [Graphical view ]
    SMARTi SM00338. BRLZ. 1 hit.
    [Graphical view ]
    PROSITEi PS50217. BZIP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx."
      White J.H., McIllhinney R.A.J., Wise A., Ciruela F., Chan W.-Y., Emson P.C., Billinton A., Marshall F.H.
      Proc. Natl. Acad. Sci. U.S.A. 97:13967-13972(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas."
      Yamada S., Ohira M., Horie H., Ando K., Takayasu H., Suzuki Y., Sugano S., Hirata T., Goto T., Matsunaga T., Hiyama E., Hayashi Y., Ando H., Suita S., Kaneko M., Sasaki F., Hashizume K., Ohnuma N., Nakagawara A.
      Oncogene 23:5901-5911(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT LEU-121.
      Tissue: Hepatoblastoma.
    3. "cDNA clone encoding leucine-zipper protein."
      Kohroki J., Tanaka K.
      Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-121.
      Tissue: Placenta.
    8. "Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis."
      Pati D., Meistrich M.L., Plon S.E.
      Mol. Cell. Biol. 19:5001-5013(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 161-282, FUNCTION, INTERACTION WITH CDC34, UBIQUITINATION.
    9. "Cyclin D3 interacts with human activating transcription factor 5 and potentiates its transcription activity."
      Liu W., Sun M., Jiang J., Shen X., Sun Q., Liu W., Shen H., Gu J.
      Biochem. Biophys. Res. Commun. 321:954-960(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CCND3, FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiATF5_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y2D1
    Secondary accession number(s): B3KND3, Q9BSA1, Q9UNQ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 130 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3