Reviewed,
UniProtKB/Swiss-Prot Q9Y2D1 (ATF5_HUMAN)
Last modified
January 19, 2010.
Version 88.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Cyclic AMP-dependent transcription factor ATF-5 Short name=cAMP-dependent transcription factor ATF-5 Alternative name(s): Activating transcription factor 5 Transcription factor ATFx | ||||
| Gene names |
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| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 282 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Transcriptional activator which binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters and blocks the differentiation of neuroprogenitor cells into neurons. Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4. Ref.8 |
| Subunit structure | Binds DNA as a dimer. Interacts with PTP4A1/PRL-1 By similarity. Interacts with CCND3, but not with CCND1 or CCND2. Ref.8 |
| Subcellular location | |
| Sequence similarities | Belongs to the bZIP family. Contains 1 bZIP domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Transcription Transcription regulation |
| Cellular component | Cytoplasm Nucleus |
| Coding sequence diversity | Polymorphism |
| Ligand | DNA-binding |
| Molecular function | Activator |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | regulation of transcription from RNA polymerase II promoter Ref.7 Traceable author statement. Source: ProtInc transcriptionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | RNA polymerase II transcription factor activity Ref.7 Traceable author statement. Source: ProtInc protein dimerization activityInferred from electronic annotation. Source: InterPro sequence-specific DNA bindingInferred from electronic annotation. Source: InterPro transcription corepressor activity Ref.7Traceable author statement. Source: ProtInc transcription factor activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 282 | 282 | Cyclic AMP-dependent transcription factor ATF-5 | PRO_0000076586 | |||||
Regions | |||||||||
| Domain | 236 – 250 | 15 | Leucine-zipper By similarity | ||||||
| DNA binding | 210 – 230 | 21 | Basic motif | ||||||
| Region | 119 – 217 | 99 | Interaction with PTP4A1 By similarity | ||||||
| Compositional bias | 123 – 139 | 17 | Poly-Pro | ||||||
| Compositional bias | 186 – 194 | 9 | Poly-Pro | ||||||
Natural variations | |||||||||
| Natural variant | 121 | 1 | L → P: dbSNP rs283526. Ref.1 Ref.3 Ref.4 Ref.5 | VAR_022786 | |||||
Experimental info | |||||||||
| Sequence conflict | 161 – 163 | 3 | LLA → RHE in AAD28370. Ref.7 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx." White J.H., McIllhinney R.A.J., Wise A., Ciruela F., Chan W.-Y., Emson P.C., Billinton A., Marshall F.H. Proc. Natl. Acad. Sci. U.S.A. 97:13967-13972(2000) [PubMed: 11087824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PRO-121. Tissue: Brain. |
| [2] | "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas." Yamada S., Ohira M., Horie H., Ando K., Takayasu H., Suzuki Y., Sugano S., Hirata T., Goto T., Matsunaga T., Hiyama E., Hayashi Y., Ando H., Suita S., Kaneko M., Sasaki F., Hashizume K., Ohnuma N., Nakagawara A. Oncogene 23:5901-5911(2004) [PubMed: 15221005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Hepatoblastoma. |
| [3] | "cDNA clone encoding leucine-zipper protein." Kohroki J., Tanaka K. Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PRO-121. |
| [4] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PRO-121. |
| [5] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PRO-121. |
| [6] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta. |
| [7] | "Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis." Pati D., Meistrich M.L., Plon S.E. Mol. Cell. Biol. 19:5001-5013(1999) [PubMed: 10373550] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 161-282. |
| [8] | "Cyclin D3 interacts with human activating transcription factor 5 and potentiates its transcription activity." Liu W., Sun M., Jiang J., Shen X., Sun Q., Liu W., Shen H., Gu J. Biochem. Biophys. Res. Commun. 321:954-960(2004) [PubMed: 15358120] [Abstract] Cited for: INTERACTION WITH CCND3, FUNCTION, SUBCELLULAR LOCATION. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF305687 mRNA. Translation: AAG22558.1. AB073613 mRNA. Translation: BAD38650.1. AB021663 mRNA. Translation: BAA78477.2. AK024402 mRNA. Translation: BAG51295.1. CH471177 Genomic DNA. Translation: EAW52581.1. BC005174 mRNA. Translation: AAH05174.1. AF101388 mRNA. Translation: AAD28370.1. |
| IPI | IPI00032057. |
| RefSeq | NP_036200.2. |
| UniGene | Hs.9754 |
3D structure databases | |
| SMR | Q9Y2D1. Positions 216-271. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q9Y2D1. 2 interactions. |
| STRING | Q9Y2D1. |
Genome annotation databases | |
| Ensembl | ENST00000306139; ENSP00000307356; ENSG00000169136; Homo sapiens. [Genome view] ENST00000423777; ENSP00000396954; ENSG00000169136; Homo sapiens. [Genome view] |
| GeneID | 22809. |
| KEGG | hsa:22809. |
Organism-specific databases | |
| CTD | 22809. |
| GeneCards | GC19P055124. |
| H-InvDB | HIX0015352. |
| HGNC | HGNC:790. ATF5. |
| MIM | 606398. gene. |
| PharmGKB | PA25090. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG20492. |
| HOGENOM | HBG269581. |
| HOVERGEN | Q9Y2D1. |
| InParanoid | Q9Y2D1. |
| OrthoDB | EOG951H9P. |
Enzyme and pathway databases | |
| Pathway_Interaction_DB | prlsignalingeventspathway. Signaling events mediated by PRL. |
Gene expression databases | |
| ArrayExpress | Q9Y2D1. |
| Bgee | Q9Y2D1. |
| CleanEx | HS_ATF5. |
| Genevestigator | Q9Y2D1. |
| GermOnline | ENSG00000169136. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR011616. bZIP_1. IPR004827. TF_bZIP. [Graphical view] |
| Pfam | PF00170. bZIP_1. 1 hit. [Graphical view] |
| SMART | SM00338. BRLZ. 1 hit. [Graphical view] |
| PROSITE | PS50217. BZIP. 1 hit. PS00036. BZIP_BASIC. False negative. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| SOURCE | Search... |
Entry information
| Entry name | ATF5_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9Y2D1 Secondary accession number(s): B3KND3, Q9BSA1, Q9UNQ3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 19 Human chromosome 19: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


