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Protein

Cyclic AMP-dependent transcription factor ATF-5

Gene

ATF5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that either stimulates or represses gene transcription through binding of different DNA regulatory elements such as cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), ATF5-specific response element (ARE) (consensus: 5'-C[CT]TCT[CT]CCTT[AT]-3') but also the amino acid response element (AARE), present in many viral and cellular promoters. Critically involved, often in a cell type-dependent manner, in cell survival, proliferation, and differentiation (PubMed:10373550, PubMed:15358120, PubMed:21212266, PubMed:20654631). Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4 (PubMed:15358120). Important regulator of the cerebral cortex formation, functions in cerebral cortical neuroprogenitor cells to maintain proliferation and to block differentiation into neurons. Must be down-regulated in order for such cells to exit the cycle and differentiate (By similarity). Participates in the pathways by which SHH promotes cerebellar granule neuron progenitor cells proliferation (By similarity). Critical for survival of mature olfactory sensory neurons (OSN), directs expression of OSN-specific genes (By similarity). May be involved in osteogenic differentiation (PubMed:22442021). Promotes cell proliferation and survival by inducing the expression of EGR1 sinergistically with ELK1. Once acetylated by EP300, binds to ARE sequences on target genes promoters, such as BCL2 and EGR1 (PubMed:21791614). Plays an anti-apoptotic role through the transcriptional regulation of BCL2, this function seems to be cell type-dependent (By similarity). Cooperates with NR1I3/CAR in the transcritpional activation of CYP2B6 in liver (PubMed:18332083). In hepatic cells, represses CRE-dependent transcription and inhibits proliferation by blocking at G2/M phase (PubMed:22528486, PubMed:18701499). May act as a negative regulator of IL1B transduction pathway in liver (PubMed:24379400). Upon IL1B stimulus, cooperates with NLK to activate the transactivation activity of C/EBP subfamily members (PubMed:25512613). Besides its function of transcription factor, acts as a cofactor of CEBPB to activate CEBPA and promote adipocyte differentiation (PubMed:24216764). Regulates centrosome dynamics in a cell-cycle- and centriole-age-dependent manner. Forms 9-foci symmetrical ring scaffold around the mother centriole to control centrosome function and the interaction between centrioles and pericentriolar material (PubMed:26213385).By similarity13 Publications

GO - Molecular functioni

  • chromatin binding Source: UniProtKB
  • kinase binding Source: UniProtKB
  • RNA polymerase II regulatory region sequence-specific DNA binding Source: NTNU_SB
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: GO_Central
  • sequence-specific DNA binding Source: UniProtKB
  • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding Source: NTNU_SB
  • transcription corepressor activity Source: ProtInc
  • transcription factor activity, sequence-specific DNA binding Source: UniProtKB
  • transcription regulatory region DNA binding Source: UniProtKB
  • tubulin binding Source: UniProtKB

GO - Biological processi

  • cerebellar granule cell precursor proliferation Source: UniProtKB
  • circadian rhythm Source: Ensembl
  • fat cell differentiation Source: UniProtKB
  • multicellular organism growth Source: Ensembl
  • negative regulation of apoptotic process Source: UniProtKB
  • negative regulation of astrocyte differentiation Source: Ensembl
  • negative regulation of cell cycle G2/M phase transition Source: UniProtKB
  • negative regulation of cell proliferation Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • olfactory bulb interneuron development Source: Ensembl
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  • post-embryonic development Source: Ensembl
  • regulation of centrosome cycle Source: UniProtKB
  • regulation of transcription, DNA-templated Source: UniProtKB
  • regulation of transcription from RNA polymerase II promoter Source: ProtInc
  • transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic AMP-dependent transcription factor ATF-5
Short name:
cAMP-dependent transcription factor ATF-5
Alternative name(s):
Activating transcription factor 5
Transcription factor ATFx
Gene namesi
Name:ATF5
Synonyms:ATFX
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:790. ATF5.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: UniProtKB
  • cytoplasm Source: HPA
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
  • transcription factor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi3 – 2523LLATL…LGWLV → AAATAGAEADRAAAPASGAG WAA: Highly increases protein levels. No effect on protein stability enhanced by IL1B. 1 PublicationAdd
BLAST
Mutagenesisi3 – 42LL → AA: Increases protein levels. No effect on protein stability enhanced by IL1B. 1 Publication
Mutagenesisi3 – 42LL → II: Decreases protein levels. 1 Publication
Mutagenesisi3 – 42LL → VV: No effect on protein levels. No effect on protein stability enhanced by IL1B. 1 Publication
Mutagenesisi7 – 71L → A: Increases protein levels. 1 Publication
Mutagenesisi9 – 113LEL → AEA: Increases protein levels. 1 Publication
Mutagenesisi15 – 162LL → AA: Increases protein levels. 1 Publication
Mutagenesisi21 – 255LGWLV → AGWAA: Increases protein levels. 1 Publication
Mutagenesisi92 – 943SPT → APA: Not phosphorylated; when associated with A-126 and A-190.
Mutagenesisi126 – 1261S → A: Not phosphorylated; when associated with 92-A--A-94 and A-190.
Mutagenesisi157 – 1571D → A: Resistant to cleavage by CASP3. 1 Publication
Mutagenesisi190 – 1901S → A: Not phosphorylated; when associated with 92-A--A-94 and A-126.

Organism-specific databases

PharmGKBiPA25090.

Chemistry

DrugBankiDB00852. Pseudoephedrine.

Polymorphism and mutation databases

BioMutaiATF5.
DMDMi308153647.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 282282Cyclic AMP-dependent transcription factor ATF-5PRO_0000076586Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei29 – 291N6-acetyllysine; by EP300By similarity

Post-translational modificationi

Ubiquitinated by CDC34 and UBE2B in order to be degraded by the proteasome. Cisplatin inhibits ubiquitination and proteasome-mediated degradation by inhibiting the interaction with CDC34 (PubMed:18458088). Ubiquitination and degradation by the proteasome are inhibited by NLK in a kinase-independent manner (PubMed:25512613).4 Publications
Phosphorylated by NLK, probably at Ser-92, Thr-94, Ser-126 and Ser-190.1 Publication
Acetylated at Lys-29 by EP300, the acetylation enhances the interaction with CEBPB, DNA-binding and transactivation activity.By similarity

Keywords - PTMi

Acetylation, Ubl conjugation

Proteomic databases

PaxDbiQ9Y2D1.
PRIDEiQ9Y2D1.
TopDownProteomicsiQ9Y2D1.

PTM databases

iPTMnetiQ9Y2D1.
PhosphoSiteiQ9Y2D1.

Expressioni

Tissue specificityi

Widely expressed with higher expression levels in liver.1 Publication

Inductioni

Down-regulated by pro-apoptotic stimuli (PubMed:21212266). However, the pro-apoptotic cisplatin increases protein levels by inhibiting polyubiquitination (PubMed:18458088). IL1B increases protein levels through protein stabilization and increase of translation efficiency (PubMed:24379400).3 Publications

Gene expression databases

BgeeiQ9Y2D1.
CleanExiHS_ATF5.
ExpressionAtlasiQ9Y2D1. baseline and differential.
GenevisibleiQ9Y2D1. HS.

Organism-specific databases

HPAiHPA030187.

Interactioni

Subunit structurei

Binds DNA as a dimer. Interacts with PTP4A1/PRL-1 (By similarity). Interacts with CCND3, but not with CCND1 or CCND2 (PubMed:15358120). Interacts with HSPA1A or HSPA1B; the interaction protects ATF5 from degradation via proteasome-dependent and caspase-dependent processes. Interacts (via C-terminal region) with NPM1 (via C-terminal region); the interaction leads to loss of association between HSPA1A or HSPA1B and ATF5 and promotes ATF5 degradation via proteasome-dependent and caspase-dependent processes (PubMed:22528486, PubMed:24379400). Interacts with NLK; the interaction stabilizes ATF5 at the protein level in a kinase-independent manner (PubMed:25512613). Interacts with alpha-tubulin, gamma-tubulin members TUBGCP2 and TUBGCP4, PCNT; the ATF5:PCNT:polyglutamylated tubulin (PGT) tripartite unites the mother centriole and the pericentriolar material (PCM) in the centrosome (PubMed:26213385). Interacts with CEBPB and EP300; EP300 is required for ATF5 and CEBPB interaction and DNA binding (By similarity).By similarity5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CEBPGP535672EBI-492509,EBI-740209
DISC1Q9NRI58EBI-492509,EBI-529989

GO - Molecular functioni

  • kinase binding Source: UniProtKB
  • tubulin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi116487. 10 interactions.
IntActiQ9Y2D1. 10 interactions.
STRINGi9606.ENSP00000396954.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2D1.
SMRiQ9Y2D1. Positions 216-271.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini208 – 27164bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2121Required for protein stabilization induced by IL1B1 PublicationAdd
BLAST
Regioni119 – 21799Interaction with PTP4A1Add
BLAST
Regioni210 – 23021Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni236 – 25015Leucine-zipperPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi123 – 13917Poly-ProAdd
BLAST
Compositional biasi186 – 1949Poly-Pro

Sequence similaritiesi

Belongs to the bZIP family.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4571. Eukaryota.
ENOG4111ZXT. LUCA.
GeneTreeiENSGT00530000063801.
HOGENOMiHOG000004844.
HOVERGENiHBG003535.
InParanoidiQ9Y2D1.
KOiK09044.
OMAiLAIYCRG.
PhylomeDBiQ9Y2D1.
TreeFamiTF316136.

Family and domain databases

InterProiIPR029855. ATF-5.
IPR004827. bZIP.
[Graphical view]
PANTHERiPTHR13044:SF3. PTHR13044:SF3. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y2D1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLLATLGLE LDRALLPASG LGWLVDYGKL PPAPAPLAPY EVLGGALEGG
60 70 80 90 100
LPVGGEPLAG DGFSDWMTER VDFTALLPLE PPLPPGTLPQ PSPTPPDLEA
110 120 130 140 150
MASLLKKELE QMEDFFLDAP PLPPPSPPPL PPPPLPPAPS LPLSLPSFDL
160 170 180 190 200
PQPPVLDTLD LLAIYCRNEA GQEEVGMPPL PPPQQPPPPS PPQPSRLAPY
210 220 230 240 250
PHPATTRGDR KQKKRDQNKS AALRYRQRKR AEGEALEGEC QGLEARNREL
260 270 280
KERAESVERE IQYVKDLLIE VYKARSQRTR SC
Length:282
Mass (Da):30,674
Last modified:October 5, 2010 - v4
Checksum:iDDB2F907CA0215A0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti161 – 1633LLA → RHE in AAD28370 (PubMed:10373550).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti121 – 1211P → L.2 Publications
Corresponds to variant rs283526 [ dbSNP | Ensembl ].
VAR_022786

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF305687 mRNA. Translation: AAG22558.1.
AB073613 mRNA. Translation: BAD38650.1.
AB021663 mRNA. Translation: BAA78477.2.
AK024402 mRNA. Translation: BAG51295.1.
AC011452 Genomic DNA. No translation available.
CH471177 Genomic DNA. Translation: EAW52581.1.
BC005174 mRNA. Translation: AAH05174.1.
AF101388 mRNA. Translation: AAD28370.1.
CCDSiCCDS12789.1.
RefSeqiNP_001180575.1. NM_001193646.1.
NP_001277675.1. NM_001290746.1.
NP_036200.2. NM_012068.5.
XP_011524931.1. XM_011526629.1.
UniGeneiHs.9754.

Genome annotation databases

EnsembliENST00000423777; ENSP00000396954; ENSG00000169136.
ENST00000595125; ENSP00000470633; ENSG00000169136.
GeneIDi22809.
KEGGihsa:22809.
UCSCiuc002prd.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF305687 mRNA. Translation: AAG22558.1.
AB073613 mRNA. Translation: BAD38650.1.
AB021663 mRNA. Translation: BAA78477.2.
AK024402 mRNA. Translation: BAG51295.1.
AC011452 Genomic DNA. No translation available.
CH471177 Genomic DNA. Translation: EAW52581.1.
BC005174 mRNA. Translation: AAH05174.1.
AF101388 mRNA. Translation: AAD28370.1.
CCDSiCCDS12789.1.
RefSeqiNP_001180575.1. NM_001193646.1.
NP_001277675.1. NM_001290746.1.
NP_036200.2. NM_012068.5.
XP_011524931.1. XM_011526629.1.
UniGeneiHs.9754.

3D structure databases

ProteinModelPortaliQ9Y2D1.
SMRiQ9Y2D1. Positions 216-271.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116487. 10 interactions.
IntActiQ9Y2D1. 10 interactions.
STRINGi9606.ENSP00000396954.

Chemistry

DrugBankiDB00852. Pseudoephedrine.

PTM databases

iPTMnetiQ9Y2D1.
PhosphoSiteiQ9Y2D1.

Polymorphism and mutation databases

BioMutaiATF5.
DMDMi308153647.

Proteomic databases

PaxDbiQ9Y2D1.
PRIDEiQ9Y2D1.
TopDownProteomicsiQ9Y2D1.

Protocols and materials databases

DNASUi22809.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000423777; ENSP00000396954; ENSG00000169136.
ENST00000595125; ENSP00000470633; ENSG00000169136.
GeneIDi22809.
KEGGihsa:22809.
UCSCiuc002prd.4. human.

Organism-specific databases

CTDi22809.
GeneCardsiATF5.
H-InvDBHIX0015352.
HGNCiHGNC:790. ATF5.
HPAiHPA030187.
MIMi606398. gene.
neXtProtiNX_Q9Y2D1.
PharmGKBiPA25090.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4571. Eukaryota.
ENOG4111ZXT. LUCA.
GeneTreeiENSGT00530000063801.
HOGENOMiHOG000004844.
HOVERGENiHBG003535.
InParanoidiQ9Y2D1.
KOiK09044.
OMAiLAIYCRG.
PhylomeDBiQ9Y2D1.
TreeFamiTF316136.

Miscellaneous databases

ChiTaRSiATF5. human.
GeneWikiiATF5.
GenomeRNAii22809.
PROiQ9Y2D1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y2D1.
CleanExiHS_ATF5.
ExpressionAtlasiQ9Y2D1. baseline and differential.
GenevisibleiQ9Y2D1. HS.

Family and domain databases

InterProiIPR029855. ATF-5.
IPR004827. bZIP.
[Graphical view]
PANTHERiPTHR13044:SF3. PTHR13044:SF3. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx."
    White J.H., McIllhinney R.A.J., Wise A., Ciruela F., Chan W.-Y., Emson P.C., Billinton A., Marshall F.H.
    Proc. Natl. Acad. Sci. U.S.A. 97:13967-13972(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas."
    Yamada S., Ohira M., Horie H., Ando K., Takayasu H., Suzuki Y., Sugano S., Hirata T., Goto T., Matsunaga T., Hiyama E., Hayashi Y., Ando H., Suita S., Kaneko M., Sasaki F., Hashizume K., Ohnuma N., Nakagawara A.
    Oncogene 23:5901-5911(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT LEU-121.
    Tissue: Hepatoblastoma.
  3. "cDNA clone encoding leucine-zipper protein."
    Kohroki J., Tanaka K.
    Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-121.
    Tissue: Placenta.
  8. "Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis."
    Pati D., Meistrich M.L., Plon S.E.
    Mol. Cell. Biol. 19:5001-5013(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 161-282, FUNCTION, UBIQUITINATION.
  9. "Cyclin D3 interacts with human activating transcription factor 5 and potentiates its transcription activity."
    Liu W., Sun M., Jiang J., Shen X., Sun Q., Liu W., Shen H., Gu J.
    Biochem. Biophys. Res. Commun. 321:954-960(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CCND3, FUNCTION, SUBCELLULAR LOCATION.
  10. "Re-expression of transcription factor ATF5 in hepatocellular carcinoma induces G2-M arrest."
    Gho J.W., Ip W.K., Chan K.Y., Law P.T., Lai P.B., Wong N.
    Cancer Res. 68:6743-6751(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DNA-BINDING.
  11. "ATF5 is a highly abundant liver-enriched transcription factor that cooperates with constitutive androstane receptor in the transactivation of CYP2B6: implications in hepatic stress responses."
    Pascual M., Gomez-Lechon M.J., Castell J.V., Jover R.
    Drug Metab. Dispos. 36:1063-1072(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  12. "Cdc34-mediated degradation of ATF5 is blocked by cisplatin."
    Wei Y., Jiang J., Liu D., Zhou J., Chen X., Zhang S., Zong H., Yun X., Gu J.
    J. Biol. Chem. 283:18773-18781(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION, INDUCTION BY CISPLATIN.
  13. "Regulation of the human CHOP gene promoter by the stress response transcription factor ATF5 via the AARE1 site in human hepatoma HepG2 cells."
    Yamazaki T., Ohmi A., Kurumaya H., Kato K., Abe T., Yamamoto H., Nakanishi N., Okuyama R., Umemura M., Kaise T., Watanabe R., Okawa Y., Takahashi S., Takahashi Y.
    Life Sci. 87:294-301(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  14. "BCL-2 is a downstream target of ATF5 that mediates the prosurvival function of ATF5 in a cell type-dependent manner."
    Dluzen D., Li G., Tacelosky D., Moreau M., Liu D.X.
    J. Biol. Chem. 286:7705-7713(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION BY PRO-APOPTOTIC STIMULI.
  15. "p300-Dependent ATF5 acetylation is essential for Egr-1 gene activation and cell proliferation and survival."
    Liu D.X., Qian D., Wang B., Yang J.M., Lu Z.
    Mol. Cell. Biol. 31:3906-3916(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  16. "Nucleophosmin (NPM1/B23) interacts with activating transcription factor 5 (ATF5) protein and promotes proteasome- and caspase-dependent ATF5 degradation in hepatocellular carcinoma cells."
    Liu X., Liu D., Qian D., Dai J., An Y., Jiang S., Stanley B., Yang J., Wang B., Liu X., Liu D.X.
    J. Biol. Chem. 287:19599-19609(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH HSPA1A; HSPA1B AND NPM1, SUBCELLULAR LOCATION, POLYUBIQUITINATION, MUTAGENESIS OF ASP-157.
  17. "ATF5, a possible regulator of osteogenic differentiation in human adipose-derived stem cells."
    Leong D.T., Abraham M.C., Gupta A., Lim T.C., Chew F.T., Hutmacher D.W.
    J. Cell. Biochem. 113:2744-2753(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  18. "N-terminal hydrophobic amino acids of activating transcription factor 5 (ATF5) protein confer interleukin 1beta (IL-1beta)-induced stabilization."
    Abe T., Kojima M., Akanuma S., Iwashita H., Yamazaki T., Okuyama R., Ichikawa K., Umemura M., Nakano H., Takahashi S., Takahashi Y.
    J. Biol. Chem. 289:3888-3900(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION BY IL1B, INTERACTION WITH HSPA1A; HSPA1B AND NPM1, MUTAGENESIS OF 3-LEU--VAL-25; 3-LEU-LEU-4; LEU-7; 9-LEU--LEU-11; 15-LEU-LEU-16 AND 21-LEU--VAL-25.
  19. "p300-dependent acetylation of activating transcription factor 5 enhances C/EBPbeta transactivation of C/EBPalpha during 3T3-L1 differentiation."
    Zhao Y., Zhang Y.D., Zhang Y.Y., Qian S.W., Zhang Z.C., Li S.F., Guo L., Liu Y., Wen B., Lei Q.Y., Tang Q.Q., Li X.
    Mol. Cell. Biol. 34:315-324(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  20. "ATF5 Connects the Pericentriolar Materials to the Proximal End of the Mother Centriole."
    Madarampalli B., Yuan Y., Liu D., Lengel K., Xu Y., Li G., Yang J., Liu X., Lu Z., Liu D.X.
    Cell 162:580-592(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH ALPHA-TUBULIN; GAMMA-TUBULIN; PCNT; TUBGCP2 AND TUBGCP4, SUBCELLULAR LOCATION.
  21. "Stabilization of ATF5 by TAK1-Nemo-like kinase critically regulates the interleukin-1beta-stimulated C/EBP signaling pathway."
    Zhang Z.Y., Li S.Z., Zhang H.H., Wu Q.R., Gong J., Liang T., Gao L., Xing N.N., Liu W.B., Du R.L., Zhang X.D.
    Mol. Cell. Biol. 35:778-788(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH NLK, PHOSPHORYLATION, UBIQUITINATION, MUTAGENESIS OF 92-SER--THR-94; SER-126 AND SER-190.

Entry informationi

Entry nameiATF5_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2D1
Secondary accession number(s): B3KND3, Q9BSA1, Q9UNQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 5, 2010
Last modified: June 8, 2016
This is version 145 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.