Reviewed, UniProtKB/Swiss-Prot Q9Y2D0 (CAH5B_HUMAN)

Names and origin

Protein names

Recommended name:
    Carbonic anhydrase 5B, mitochondrial
    EC=4.2.1.1
Alternative name(s):
    Carbonic anhydrase VB
      Short name=CA-VB
    Carbonate dehydratase VB

Gene names

Name:

CA5B

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	317 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Reversible hydration of carbon dioxide.
Catalytic activity	H2CO3 = CO2 + H2O.
Cofactor	Zinc By similarity.
Subcellular location	Mitochondrion.
Tissue specificity	Strongest expression in heart, pancreas, kidney, placenta, lung, and skeletal muscle. Not expressed in liver.
Sequence similarities	Belongs to the alpha-carbonic anhydrase family.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	Metal-binding Zinc
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	one-carbon compound metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	mitochondrion Ref.1 Traceable author statement. Source: ProtInc
Molecular function	carbonate dehydratase activity Ref.1 Traceable author statement. Source: ProtInc zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 33	33	Mitochondrion
	Chain	34 – 317	284	Carbonic anhydrase 5B, mitochondrial		PRO_0000004237
Sites
	Metal binding	130	1	Zinc; catalytic By similarity
	Metal binding	132	1	Zinc; catalytic By similarity
	Metal binding	155	1	Zinc; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9Y2D0-1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 7CA11920EFF2588A	FASTA	317	36,434
	10 20 30 40 50 60 MVVMNSLRVI LQASPGKLLW RKFQIPRFMP ARPCSLYTCT YKTRNRALHP LWESVDLVPG 70 80 90 100 110 120 GDRQSPINIR WRDSVYDPGL KPLTISYDPA TCLHVWNNGY SFLVEFEDST DKSVIKGGPL 130 140 150 160 170 180 EHNYRLKQFH FHWGAIDAWG SEHTVDSKCF PAELHLVHWN AVRFENFEDA ALEENGLAVI 190 200 210 220 230 240 GVFLKLGKHH KELQKLVDTL PSIKHKDALV EFGSFDPSCL MPTCPDYWTY SGSLTTPPLS 250 260 270 280 290 300 ESVTWIIKKQ PVEVDHDQLE QFRTLLFTSE GEKEKRMVDN FRPLQPLMNR TVRSSFRHDY 310 VLNVQAKPKP ATSQATP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human mitochondrial carbonic anhydrase VB: cDNA cloning, mRNA expression, subcellular localization, and mapping to chromosome X." Fujikawa-Adachi K., Nishimori I., Taguchi T., Onishi S. J. Biol. Chem. 274:21228-21233(1999) [PubMed: 10409679] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION. Tissue: Pancreas.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Blood.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB021660 mRNA. Translation: BAA76671.1. BC028142 mRNA. Translation: AAH28142.1.
IPI	IPI00032055.
RefSeq	NP_009151.1.
UniGene	Hs.653287
3D structure databases
HSSP	HSSP built from PDB template 1KEQ based on UniProtKB P23589.
ModBase	Search...
Proteomic databases
PRIDE	Q9Y2D0.
Genome annotation databases
Ensembl	ENSG00000169239. Homo sapiens. [Contig view]
GeneID	11238.
KEGG	hsa:11238.
UCSC	uc004cxe.1. human.
Organism-specific databases
GeneCards	GC0XP015666.
H-InvDB	HIX0016672.
HGNC	HGNC:1378. CA5B.
HPA	HPA012618.
MIM	300230. gene.
PharmGKB	PA25993.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9Y2D0.
HOVERGEN	Q9Y2D0.
OMA	Q9Y2D0. SVIEGGP.
Enzyme and pathway databases
BRENDA	4.2.1.1. 247.
Gene expression databases
ArrayExpress	Q9Y2D0.
Bgee	Q9Y2D0.
CleanEx	HS_CA5B.
GermOnline	ENSG00000169239. Homo sapiens.
Family and domain databases
InterPro	IPR001148. Carbonic_anhydrase_a-class_cat. IPR018338. Carbonic_anhydrase_a-class_CS. IPR018437. Carbonic_anhydrase_CA5_mt. [Graphical view]
Gene3D	G3DSA:3.10.200.10. Euk_COanhd. 1 hit.
PANTHER	PTHR18952:SF25. Carbonic_anhydrase_CA5_mt. 1 hit. PTHR18952. Euk_COanhd. 1 hit.
Pfam	PF00194. Carb_anhydrase. 1 hit. [Graphical view]
ProDom	PD000865. Euk_COanhd. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00162. ALPHA_CA_1. 1 hit. PS51144. ALPHA_CA_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
BindingDB	Q9Y2D0.
NextBio	42774.
SOURCE	Search...

Entry information

Entry name

CAH5B_HUMAN

Accession

Primary (citable) accession number: Q9Y2D0

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	November 1, 1999
Last modified:	July 7, 2009
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)