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Protein

Carbonic anhydrase 5B, mitochondrial

Gene

CA5B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Reversible hydration of carbon dioxide.

Catalytic activityi

H2CO3 = CO2 + H2O.

Cofactori

Zn2+By similarity

Enzyme regulationi

Inhibited by coumarins, sulfonamide derivatives such as acetazolamide (AZA), saccharin and Foscarnet (phosphonoformate trisodium salt).4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi130Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi132Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi155Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
LigandMetal-binding, Zinc

Enzyme and pathway databases

BRENDAi4.2.1.1 2681
ReactomeiR-HSA-1475029 Reversible hydration of carbon dioxide

Names & Taxonomyi

Protein namesi
Recommended name:
Carbonic anhydrase 5B, mitochondrial (EC:4.2.1.1)
Alternative name(s):
Carbonate dehydratase VB
Carbonic anhydrase VB
Short name:
CA-VB
Gene namesi
Name:CA5B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000169239.12
HGNCiHGNC:1378 CA5B
MIMi300230 gene
neXtProtiNX_Q9Y2D0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000169239
PharmGKBiPA25993

Chemistry databases

ChEMBLiCHEMBL3969
DrugBankiDB08846 Ellagic Acid
DB00909 Zonisamide

Polymorphism and mutation databases

BioMutaiCA5B
DMDMi8928041

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 33MitochondrionAdd BLAST33
ChainiPRO_000000423734 – 317Carbonic anhydrase 5B, mitochondrialAdd BLAST284

Proteomic databases

EPDiQ9Y2D0
PaxDbiQ9Y2D0
PeptideAtlasiQ9Y2D0
PRIDEiQ9Y2D0

PTM databases

iPTMnetiQ9Y2D0
PhosphoSitePlusiQ9Y2D0

Expressioni

Tissue specificityi

Strongest expression in heart, pancreas, kidney, placenta, lung, and skeletal muscle. Not expressed in liver.

Gene expression databases

BgeeiENSG00000169239
CleanExiHS_CA5B
ExpressionAtlasiQ9Y2D0 baseline and differential
GenevisibleiQ9Y2D0 HS

Organism-specific databases

HPAiHPA012618

Interactioni

Protein-protein interaction databases

BioGridi116403, 5 interactors
STRINGi9606.ENSP00000314099

Chemistry databases

BindingDBiQ9Y2D0

Structurei

3D structure databases

ProteinModelPortaliQ9Y2D0
SMRiQ9Y2D0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 296Alpha-carbonic anhydrasePROSITE-ProRule annotationAdd BLAST260

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni235 – 236Substrate bindingBy similarity2

Sequence similaritiesi

Belongs to the alpha-carbonic anhydrase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0382 Eukaryota
COG3338 LUCA
GeneTreeiENSGT00760000118915
HOGENOMiHOG000112637
HOVERGENiHBG002837
InParanoidiQ9Y2D0
KOiK01672
OMAiIKHKDTL
OrthoDBiEOG091G0XFM
PhylomeDBiQ9Y2D0
TreeFamiTF316425

Family and domain databases

Gene3Di3.10.200.10, 1 hit
InterProiView protein in InterPro
IPR018437 CA-VB_mt
IPR001148 CA_dom
IPR036398 CA_dom_sf
IPR023561 Carbonic_anhydrase_a-class
IPR018338 Carbonic_anhydrase_a-class_CS
PANTHERiPTHR18952 PTHR18952, 1 hit
PTHR18952:SF25 PTHR18952:SF25, 1 hit
PfamiView protein in Pfam
PF00194 Carb_anhydrase, 1 hit
SMARTiView protein in SMART
SM01057 Carb_anhydrase, 1 hit
SUPFAMiSSF51069 SSF51069, 1 hit
PROSITEiView protein in PROSITE
PS00162 ALPHA_CA_1, 1 hit
PS51144 ALPHA_CA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y2D0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVMNSLRVI LQASPGKLLW RKFQIPRFMP ARPCSLYTCT YKTRNRALHP
60 70 80 90 100
LWESVDLVPG GDRQSPINIR WRDSVYDPGL KPLTISYDPA TCLHVWNNGY
110 120 130 140 150
SFLVEFEDST DKSVIKGGPL EHNYRLKQFH FHWGAIDAWG SEHTVDSKCF
160 170 180 190 200
PAELHLVHWN AVRFENFEDA ALEENGLAVI GVFLKLGKHH KELQKLVDTL
210 220 230 240 250
PSIKHKDALV EFGSFDPSCL MPTCPDYWTY SGSLTTPPLS ESVTWIIKKQ
260 270 280 290 300
PVEVDHDQLE QFRTLLFTSE GEKEKRMVDN FRPLQPLMNR TVRSSFRHDY
310
VLNVQAKPKP ATSQATP
Length:317
Mass (Da):36,434
Last modified:November 1, 1999 - v1
Checksum:i7CA11920EFF2588A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB021660 mRNA Translation: BAA76671.1
AK291050 mRNA Translation: BAF83739.1
CH471074 Genomic DNA Translation: EAW98897.1
BC028142 mRNA Translation: AAH28142.1
CCDSiCCDS14171.1
RefSeqiNP_009151.1, NM_007220.3
XP_005274499.1, XM_005274442.4
UniGeneiHs.653287

Genome annotation databases

EnsembliENST00000318636; ENSP00000314099; ENSG00000169239
ENST00000454127; ENSP00000417021; ENSG00000169239
GeneIDi11238
KEGGihsa:11238
UCSCiuc004cxe.4 human

Similar proteinsi

Entry informationi

Entry nameiCAH5B_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2D0
Secondary accession number(s): A8K4T5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: May 23, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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