Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot Q9Y2D0 (CAH5B_HUMAN)

Last modified July 7, 2009. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Carbonic anhydrase 5B, mitochondrial
    EC=4.2.1.1
Alternative name(s):
    Carbonic anhydrase VB
      Short name=CA-VB
    Carbonate dehydratase VB
Gene names
Name: CA5B
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length317 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Reversible hydration of carbon dioxide.

Catalytic activity

H2CO3 = CO2 + H2O.

Cofactor

Zinc By similarity.

Subcellular location

Mitochondrion.

Tissue specificity

Strongest expression in heart, pancreas, kidney, placenta, lung, and skeletal muscle. Not expressed in liver.

Sequence similarities

Belongs to the alpha-carbonic anhydrase family.

Ontologies

Keywords
   Cellular componentMitochondrion
   DomainTransit peptide
   LigandMetal-binding
Zinc
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processone-carbon compound metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentmitochondrion Ref.1

Traceable author statement. Source: ProtInc

   Molecular functioncarbonate dehydratase activity Ref.1

Traceable author statement. Source: ProtInc

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3333Mitochondrion
Chain34 – 317284Carbonic anhydrase 5B, mitochondrial
PRO_0000004237

Sites

Metal binding1301Zinc; catalytic By similarity
Metal binding1321Zinc; catalytic By similarity
Metal binding1551Zinc; catalytic By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9Y2D0-1 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 7CA11920EFF2588A

FASTA31736,434
        10         20         30         40         50         60 
MVVMNSLRVI LQASPGKLLW RKFQIPRFMP ARPCSLYTCT YKTRNRALHP LWESVDLVPG 

        70         80         90        100        110        120 
GDRQSPINIR WRDSVYDPGL KPLTISYDPA TCLHVWNNGY SFLVEFEDST DKSVIKGGPL 

       130        140        150        160        170        180 
EHNYRLKQFH FHWGAIDAWG SEHTVDSKCF PAELHLVHWN AVRFENFEDA ALEENGLAVI 

       190        200        210        220        230        240 
GVFLKLGKHH KELQKLVDTL PSIKHKDALV EFGSFDPSCL MPTCPDYWTY SGSLTTPPLS 

       250        260        270        280        290        300 
ESVTWIIKKQ PVEVDHDQLE QFRTLLFTSE GEKEKRMVDN FRPLQPLMNR TVRSSFRHDY 

       310 
VLNVQAKPKP ATSQATP 

« Hide

References

« Hide 'large scale' references
[1]"Human mitochondrial carbonic anhydrase VB: cDNA cloning, mRNA expression, subcellular localization, and mapping to chromosome X."
Fujikawa-Adachi K., Nishimori I., Taguchi T., Onishi S.
J. Biol. Chem. 274:21228-21233(1999) [PubMed: 10409679] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
Tissue: Pancreas.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Blood.
+Additional computationally mapped references.

Cross-references

Sequence databases

AB021660 mRNA. Translation: BAA76671.1.
BC028142 mRNA. Translation: AAH28142.1.
IPIIPI00032055.
RefSeqNP_009151.1.
UniGeneHs.653287

3D structure databases

HSSPHSSP built from PDB template 1KEQ based on UniProtKB P23589.
ModBaseSearch...

Proteomic databases

PRIDEQ9Y2D0.

Genome annotation databases

EnsemblENSG00000169239. Homo sapiens. [Contig view]
GeneID11238.
KEGGhsa:11238.
UCSCuc004cxe.1. human.

Organism-specific databases

GeneCardsGC0XP015666.
H-InvDBHIX0016672.
HGNCHGNC:1378. CA5B.
HPAHPA012618.
MIM300230. gene.
PharmGKBPA25993.
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ9Y2D0.
HOVERGENQ9Y2D0.
OMAQ9Y2D0. SVIEGGP.

Enzyme and pathway databases

BRENDA4.2.1.1. 247.

Gene expression databases

ArrayExpressQ9Y2D0.
BgeeQ9Y2D0.
CleanExHS_CA5B.
GermOnlineENSG00000169239. Homo sapiens.

Family and domain databases

InterProIPR001148. Carbonic_anhydrase_a-class_cat.
IPR018338. Carbonic_anhydrase_a-class_CS.
IPR018437. Carbonic_anhydrase_CA5_mt.
[Graphical view]
Gene3DG3DSA:3.10.200.10. Euk_COanhd. 1 hit.
PANTHERPTHR18952:SF25. Carbonic_anhydrase_CA5_mt. 1 hit.
PTHR18952. Euk_COanhd. 1 hit.
PfamPF00194. Carb_anhydrase. 1 hit.
[Graphical view]
ProDomPD000865. Euk_COanhd. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEPS00162. ALPHA_CA_1. 1 hit.
PS51144. ALPHA_CA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

BindingDBQ9Y2D0.
NextBio42774.
SOURCESearch...

Entry information

Entry nameCAH5B_HUMAN
AccessionPrimary (citable) accession number: Q9Y2D0
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: July 7, 2009
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents