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Reviewed, UniProtKB/Swiss-Prot Q9Y2C9 (TLR6_HUMAN)

Last modified February 9, 2010. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Toll-like receptor 6
Alternative name(s):
    CD_antigen=CD286
Gene names
Name: TLR6
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length796 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Participates in the innate immune response to Gram-positive bacteria and fungi. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2. Ref.3

Subunit structure

Binds TLR2 via their respective extracellular domains. Binds MYD88 via their respective TIR domains By similarity.

Subcellular location

Cell membrane; Single-pass type I membrane protein By similarity. Cytoplasmic vesicle › phagosome membrane; Single-pass type I membrane protein By similarity.

Tissue specificity

Detected in monocytes, CD11c+ immature dendritic cells, plasmacytoid pre-dendritic cells and dermal microvessel endothelial cells.

Sequence similarities

Belongs to the Toll-like receptor family.

Contains 13 LRR (leucine-rich) repeats.

Contains 1 TIR domain.

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Ontologies

Keywords
   Biological processImmune response
Inflammatory response
Innate immunity
   Cellular componentCell membrane
Cytoplasmic vesicle
Membrane
   Coding sequence diversityPolymorphism
   DomainLeucine-rich repeat
Repeat
Signal
Transmembrane
   Molecular functionReceptor
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processT-helper 1 type immune response

Inferred by curator. Source: UniProtKB

activation of NF-kappaB-inducing kinase activity Ref.1

Non-traceable author statement. Source: UniProtKB

defense response to bacterium

Traceable author statement. Source: ProtInc

inflammatory response

Inferred from electronic annotation. Source: UniProtKB-KW

innate immune response

Inferred from electronic annotation. Source: UniProtKB-KW

positive regulation of I-kappaB kinase/NF-kappaB cascade Ref.1

Inferred from direct assay. Source: MGI

positive regulation of JUN kinase activity Ref.1

Inferred from direct assay. Source: MGI

positive regulation of interleukin-6 biosynthetic process

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular componentcytoplasmic vesicle

Inferred from electronic annotation. Source: UniProtKB-KW

integral to plasma membrane Ref.1

Traceable author statement. Source: ProtInc

   Molecular functionlipoprotein binding

Inferred from sequence or structural similarity. Source: UniProtKB

transmembrane receptor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3131 Potential
Chain32 – 796765Toll-like receptor 6
PRO_0000034731

Regions

Topological domain32 – 586555Extracellular Potential
Transmembrane587 – 60721 Potential
Topological domain608 – 796189Cytoplasmic Potential
Repeat51 – 7424LRR 1
Repeat75 – 9824LRR 2
Repeat100 – 12021LRR 3
Repeat121 – 14424LRR 4
Repeat158 – 17518LRR 5
Repeat176 – 20126LRR 6
Repeat222 – 24827LRR 7
Repeat376 – 40025LRR 8
Repeat402 – 42827LRR 9
Repeat430 – 44718LRR 10
Repeat449 – 47224LRR 11
Repeat474 – 49623LRR 12
Repeat498 – 51720LRR 13
Domain640 – 784145TIR

Amino acid modifications

Glycosylation1441N-linked (GlcNAc...) Potential
Glycosylation1861N-linked (GlcNAc...) Potential
Glycosylation2141N-linked (GlcNAc...) Potential
Glycosylation2531N-linked (GlcNAc...) Potential
Glycosylation2851N-linked (GlcNAc...) Potential
Glycosylation3591N-linked (GlcNAc...) Potential
Glycosylation4231N-linked (GlcNAc...) Potential
Glycosylation4341N-linked (GlcNAc...) Potential
Glycosylation5831N-linked (GlcNAc...) Potential

Natural variations

Natural variant1201I → T: dbSNP rs5743808. Ref.2
VAR_057289
Natural variant1941L → P: dbSNP rs5743809.
VAR_057290
Natural variant2471R → K: dbSNP rs35220466.
VAR_057291
Natural variant3271V → M: dbSNP rs3796508. Ref.2
VAR_057292
Natural variant3451H → Y: dbSNP rs5743813.
VAR_057293
Natural variant4271V → A: dbSNP rs5743815.
VAR_057294
Natural variant4651V → I: dbSNP rs5743816.
VAR_057295
Natural variant4741A → T: dbSNP rs35762983.
VAR_057296
Natural variant7831M → V: dbSNP rs5743822.
VAR_057297

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Sequences

Sequence LengthMass (Da)Tools
Q9Y2C9-1 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 35CEAEC05BFBA8BD

FASTA79691,890
        10         20         30         40         50         60 
MTKDKEPIVK SFHFVCLMII IVGTRIQFSD GNEFAVDKSK RGLIHVPKDL PLKTKVLDMS 

        70         80         90        100        110        120 
QNYIAELQVS DMSFLSELTV LRLSHNRIQL LDLSVFKFNQ DLEYLDLSHN QLQKISCHPI 

       130        140        150        160        170        180 
VSFRHLDLSF NDFKALPICK EFGNLSQLNF LGLSAMKLQK LDLLPIAHLH LSYILLDLRN 

       190        200        210        220        230        240 
YYIKENETES LQILNAKTLH LVFHPTSLFA IQVNISVNTL GCLQLTNIKL NDDNCQVFIK 

       250        260        270        280        290        300 
FLSELTRGPT LLNFTLNHIE TTWKCLVRVF QFLWPKPVEY LNIYNLTIIE SIREEDFTYS 

       310        320        330        340        350        360 
KTTLKALTIE HITNQVFLFS QTALYTVFSE MNIMMLTISD TPFIHMLCPH APSTFKFLNF 

       370        380        390        400        410        420 
TQNVFTDSIF EKCSTLVKLE TLILQKNGLK DLFKVGLMTK DMPSLEILDV SWNSLESGRH 

       430        440        450        460        470        480 
KENCTWVESI VVLNLSSNML TDSVFRCLPP RIKVLDLHSN KIKSVPKQVV KLEALQELNV 

       490        500        510        520        530        540 
AFNSLTDLPG CGSFSSLSVL IIDHNSVSHP SADFFQSCQK MRSIKAGDNP FQCTCELREF 

       550        560        570        580        590        600 
VKNIDQVSSE VLEGWPDSYK CDYPESYRGS PLKDFHMSEL SCNITLLIVT IGATMLVLAV 

       610        620        630        640        650        660 
TVTSLCIYLD LPWYLRMVCQ WTQTRRRARN IPLEELQRNL QFHAFISYSE HDSAWVKSEL 

       670        680        690        700        710        720 
VPYLEKEDIQ ICLHERNFVP GKSIVENIIN CIEKSYKSIF VLSPNFVQSE WCHYELYFAH 

       730        740        750        760        770        780 
HNLFHEGSNN LILILLEPIP QNSIPNKYHK LKALMTQRTY LQWPKEKSKR GLFWANIRAA 

       790 
FNMKLTLVTE NNDVKS

« Hide

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References

[1]"TLR6: a novel member of an expanding Toll-like receptor family."
Takeuchi O., Kawai T., Sanjo H., Copeland N.G., Gilbert D.J., Jenkins N.A., Takeda K., Akira S.
Gene 231:59-65(1999) [PubMed: 10231569] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Placenta.
[2]"The novel allele of toll-like receptor 6 gene."
Liu Z., Xiao W., Wang J., Li N., Tai Y.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-120 AND MET-327.
[3]"Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling."
Bulut Y., Faure E., Thomas L., Equils O., Arditi M.
J. Immunol. 167:987-994(2001) [PubMed: 11441107] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB020807 mRNA. Translation: BAA78631.1.
EU170528 Genomic DNA. Translation: ABW37063.1.
EU170529 Genomic DNA. Translation: ABW37064.1.
EU170531 Genomic DNA. Translation: ABW37066.1.
EU170532 Genomic DNA. Translation: ABW37067.1.
EU170533 Genomic DNA. Translation: ABW37068.1.
EU170534 Genomic DNA. Translation: ABW37069.1.
EU170536 Genomic DNA. Translation: ABW37071.1.
EU195537 Genomic DNA. Translation: ABY67113.1.
EU195538 Genomic DNA. Translation: ABY67114.1.
EU195539 Genomic DNA. Translation: ABY67115.1.
EU195541 Genomic DNA. Translation: ABY67117.1.
EU195542 Genomic DNA. Translation: ABY67118.1.
EU195543 Genomic DNA. Translation: ABY67119.1.
EU195544 Genomic DNA. Translation: ABY67120.1.
EU195545 Genomic DNA. Translation: ABY67121.1.
EU195546 Genomic DNA. Translation: ABY67122.1.
EU195547 Genomic DNA. Translation: ABY67123.1.
EU195548 Genomic DNA. Translation: ABY67124.1.
EU195550 Genomic DNA. Translation: ABY67126.1.
EU195551 Genomic DNA. Translation: ABY67127.1.
EU195553 Genomic DNA. Translation: ABY67129.1.
EU195554 Genomic DNA. Translation: ABY67130.1.
EU195555 Genomic DNA. Translation: ABY67131.1.
EU195557 Genomic DNA. Translation: ABY67133.1.
IPIIPI00294125.
UniGeneHs.654532
Hs.661550
Hs.662185

3D structure databases

SMRQ9Y2C9. Positions 33-556, 630-786.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9Y2C9.

PTM databases

PhosphoSiteQ9Y2C9.

Proteomic databases

PRIDEQ9Y2C9.

Genome annotation databases

EnsemblENST00000381950; ENSP00000371376; ENSG00000174130; Homo sapiens. [Genome view]
ENST00000436693; ENSP00000389600; ENSG00000174130; Homo sapiens. [Genome view]
UCSCuc003gtm.2. human.

Organism-specific databases

GeneCardsGC04M038504.
H-InvDBHIX0031342.
HGNCHGNC:16711. TLR6.
MIM605403. gene.
PharmGKBPA38183.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG12467.
HOGENOMHBG444147.
HOVERGENQ9Y2C9.
InParanoidQ9Y2C9.

Enzyme and pathway databases

ReactomeREACT_6900. Signaling in Immune system.

Gene expression databases

ArrayExpressQ9Y2C9.
BgeeQ9Y2C9.
CleanExHS_TLR6.
GenevestigatorQ9Y2C9.
GermOnlineENSG00000174130. Homo sapiens.

Family and domain databases

InterProIPR000483. Cys-rich_flank_reg_C.
IPR004075. IL1_rcpt_1.
IPR001611. Leu-rich_rpt.
IPR000157. Toll-Interleukin_rcpt.
IPR020474. Toll-like_rcpt_LRR-contain.
IPR017241. Toll-like_receptor.
[Graphical view]
PfamPF00560. LRR_1. 1 hit.
PF01463. LRRCT. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
PIRSFPIRSF037595. Toll-like_receptor. 1 hit.
PRINTSPR01537. INTRLKN1R1F.
PR00019. LEURICHRPT.
SMARTSM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
PROSITEPS51450. LRR. 9 hits.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio39189.
SOURCESearch...

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Entry information

Entry nameTLR6_HUMAN
AccessionPrimary (citable) accession number: Q9Y2C9
Secondary accession number(s): B6CH35, B6RFS4, B6RFS5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: November 1, 1999
Last modified: February 9, 2010
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Human chromosome 4: entries, gene names and cross-references to MIM

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List of human entries with polymorphisms or disease mutations

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Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents