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Protein

Toll-like receptor 6

Gene

TLR6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Participates in the innate immune response to Gram-positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides (PubMed:20037584). In response to diacylated lipopeptides, forms the activation cluster TLR2:TLR6:CD14:CD36, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2 (PubMed:11441107). In complex with TLR4, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion (PubMed:11441107, PubMed:20037584).3 Publications

GO - Molecular functioni

  • lipopeptide binding Source: UniProtKB
  • receptor activity Source: ProtInc
  • Toll-like receptor 2 binding Source: UniProtKB
  • transmembrane signaling receptor activity Source: GO_Central

GO - Biological processi

  • activation of NF-kappaB-inducing kinase activity Source: UniProtKB
  • cellular response to diacyl bacterial lipopeptide Source: UniProtKB
  • defense response to bacterium Source: ProtInc
  • detection of diacyl bacterial lipopeptide Source: MGI
  • immune response Source: ProtInc
  • inflammatory response Source: UniProtKB-KW
  • innate immune response Source: UniProtKB-KW
  • interleukin-1 beta secretion Source: UniProtKB
  • microglial cell activation Source: Ensembl
  • MyD88-dependent toll-like receptor signaling pathway Source: Reactome
  • nitric oxide metabolic process Source: Ensembl
  • positive regulation of I-kappaB kinase/NF-kappaB signaling Source: MGI
  • positive regulation of interleukin-6 biosynthetic process Source: UniProtKB
  • positive regulation of JUN kinase activity Source: MGI
  • positive regulation of NLRP3 inflammasome complex assembly Source: UniProtKB
  • regulation of cytokine secretion Source: InterPro
  • signal transduction Source: ProtInc
  • T-helper 1 type immune response Source: UniProtKB
  • toll-like receptor 6 signaling pathway Source: InterPro
  • toll-like receptor signaling pathway Source: GO_Central
  • toll-like receptor TLR6:TLR2 signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

BioCyciZFISH:ENSG00000174130-MONOMER.
ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-166058. MyD88:Mal cascade initiated on plasma membrane.
R-HSA-168188. Toll Like Receptor TLR6:TLR2 Cascade.
R-HSA-5602498. MyD88 deficiency (TLR2/4).
R-HSA-5603041. IRAK4 deficiency (TLR2/4).
R-HSA-5686938. Regulation of TLR by endogenous ligand.
SIGNORiQ9Y2C9.

Names & Taxonomyi

Protein namesi
Recommended name:
Toll-like receptor 6
Alternative name(s):
CD_antigen: CD286
Gene namesi
Name:TLR6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:16711. TLR6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini32 – 586ExtracellularSequence analysisAdd BLAST555
Transmembranei587 – 607HelicalSequence analysisAdd BLAST21
Topological domaini608 – 796CytoplasmicSequence analysisAdd BLAST189

GO - Cellular componenti

  • Golgi apparatus Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • membrane raft Source: UniProtKB
  • phagocytic vesicle membrane Source: UniProtKB-SubCell
  • plasma membrane Source: Reactome
  • Toll-like receptor 2-Toll-like receptor 6 protein complex Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10333.
OpenTargetsiENSG00000174130.
PharmGKBiPA38183.

Chemistry databases

ChEMBLiCHEMBL3301399.

Polymorphism and mutation databases

BioMutaiTLR6.
DMDMi296452933.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000003473132 – 796Toll-like receptor 6Add BLAST765

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi117 ↔ 139By similarity
Glycosylationi144N-linked (GlcNAc...)Sequence analysis1
Glycosylationi186N-linked (GlcNAc...)Sequence analysis1
Glycosylationi214N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi235 ↔ 265By similarity
Glycosylationi253N-linked (GlcNAc...)Sequence analysis1
Glycosylationi285N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi348 ↔ 373By similarity
Glycosylationi359N-linked (GlcNAc...)Sequence analysis1
Glycosylationi423N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi424 ↔ 447By similarity
Glycosylationi434N-linked (GlcNAc...)Sequence analysis1
Glycosylationi583N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9Y2C9.
PeptideAtlasiQ9Y2C9.
PRIDEiQ9Y2C9.

PTM databases

iPTMnetiQ9Y2C9.
PhosphoSitePlusiQ9Y2C9.

Expressioni

Tissue specificityi

Detected in monocytes, CD11c+ immature dendritic cells, plasmacytoid pre-dendritic cells and dermal microvessel endothelial cells.

Gene expression databases

BgeeiENSG00000174130.
CleanExiHS_TLR6.
ExpressionAtlasiQ9Y2C9. baseline and differential.
GenevisibleiQ9Y2C9. HS.

Interactioni

Subunit structurei

Heterodimer with TLR2 via their respective extracellular domains (PubMed:16880211). Binds MYD88 via their respective TIR domains (Probable). Interacts with CD36, following CD36 stimulation by oxLDL or amyloid-beta 42, and forms a heterodimer with TLR4. The trimeric complex is internalized and triggers inflammatory response. LYN kinase activity facilitates TLR4:TLR6 heterodimerization and signal initiation (PubMed:20037584). The heterodimer TLR2:TLR6 interacts with CD14 and CD36 in response to triacylated lipopeptides (PubMed:16880211).Curated2 Publications

GO - Molecular functioni

  • Toll-like receptor 2 binding Source: UniProtKB

Protein-protein interaction databases

BioGridi115616. 3 interactors.
STRINGi9606.ENSP00000371376.

Structurei

Secondary structure

1796
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi642 – 647Combined sources6
Helixi650 – 652Combined sources3
Helixi653 – 658Combined sources6
Helixi660 – 666Combined sources7
Helixi674 – 677Combined sources4
Helixi684 – 694Combined sources11
Beta strandi695 – 702Combined sources8
Helixi704 – 709Combined sources6
Helixi711 – 717Combined sources7
Helixi722 – 724Combined sources3
Beta strandi725 – 727Combined sources3
Beta strandi731 – 737Combined sources7
Helixi741 – 743Combined sources3
Helixi749 – 757Combined sources9
Helixi772 – 780Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4OM7X-ray2.20A/B640-796[»]
ProteinModelPortaliQ9Y2C9.
SMRiQ9Y2C9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati54 – 77LRR 1Add BLAST24
Repeati78 – 101LRR 2Add BLAST24
Repeati102 – 122LRR 3Add BLAST21
Repeati123 – 147LRR 4Add BLAST25
Repeati148 – 168LRR 5Add BLAST21
Repeati169 – 196LRR 6Add BLAST28
Repeati197 – 219LRR 7Add BLAST23
Repeati220 – 250LRR 8Add BLAST31
Repeati251 – 277LRR 9Add BLAST27
Repeati278 – 303LRR 10Add BLAST26
Repeati304 – 330LRR 11Add BLAST27
Repeati331 – 354LRR 12Add BLAST24
Repeati355 – 378LRR 13Add BLAST24
Repeati379 – 404LRR 14Add BLAST26
Repeati405 – 429LRR 15Add BLAST25
Repeati430 – 450LRR 16Add BLAST21
Repeati451 – 474LRR 17Add BLAST24
Repeati475 – 496LRR 18Add BLAST22
Repeati497 – 520LRR 19Add BLAST24
Domaini521 – 575LRRCTAdd BLAST55
Domaini640 – 784TIRPROSITE-ProRule annotationAdd BLAST145

Sequence similaritiesi

Belongs to the Toll-like receptor family.Curated
Contains 19 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 TIR domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4641. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000119006.
HOGENOMiHOG000008676.
HOVERGENiHBG023180.
InParanoidiQ9Y2C9.
KOiK10169.
OMAiSIPNKYH.
OrthoDBiEOG091G0356.
PhylomeDBiQ9Y2C9.
TreeFamiTF351113.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
3.80.10.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
IPR027187. TLR6.
IPR017241. Toll-like_receptor.
[Graphical view]
PANTHERiPTHR24365:SF23. PTHR24365:SF23. 1 hit.
PfamiPF13855. LRR_8. 2 hits.
PF01463. LRRCT. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
PIRSFiPIRSF037595. Toll-like_receptor. 1 hit.
SMARTiSM00369. LRR_TYP. 5 hits.
SM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 3 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 9 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y2C9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTKDKEPIVK SFHFVCLMII IVGTRIQFSD GNEFAVDKSK RGLIHVPKDL
60 70 80 90 100
PLKTKVLDMS QNYIAELQVS DMSFLSELTV LRLSHNRIQL LDLSVFKFNQ
110 120 130 140 150
DLEYLDLSHN QLQKISCHPI VSFRHLDLSF NDFKALPICK EFGNLSQLNF
160 170 180 190 200
LGLSAMKLQK LDLLPIAHLH LSYILLDLRN YYIKENETES LQILNAKTLH
210 220 230 240 250
LVFHPTSLFA IQVNISVNTL GCLQLTNIKL NDDNCQVFIK FLSELTRGST
260 270 280 290 300
LLNFTLNHIE TTWKCLVRVF QFLWPKPVEY LNIYNLTIIE SIREEDFTYS
310 320 330 340 350
KTTLKALTIE HITNQVFLFS QTALYTVFSE MNIMMLTISD TPFIHMLCPH
360 370 380 390 400
APSTFKFLNF TQNVFTDSIF EKCSTLVKLE TLILQKNGLK DLFKVGLMTK
410 420 430 440 450
DMPSLEILDV SWNSLESGRH KENCTWVESI VVLNLSSNML TDSVFRCLPP
460 470 480 490 500
RIKVLDLHSN KIKSVPKQVV KLEALQELNV AFNSLTDLPG CGSFSSLSVL
510 520 530 540 550
IIDHNSVSHP SADFFQSCQK MRSIKAGDNP FQCTCELREF VKNIDQVSSE
560 570 580 590 600
VLEGWPDSYK CDYPESYRGS PLKDFHMSEL SCNITLLIVT IGATMLVLAV
610 620 630 640 650
TVTSLCIYLD LPWYLRMVCQ WTQTRRRARN IPLEELQRNL QFHAFISYSE
660 670 680 690 700
HDSAWVKSEL VPYLEKEDIQ ICLHERNFVP GKSIVENIIN CIEKSYKSIF
710 720 730 740 750
VLSPNFVQSE WCHYELYFAH HNLFHEGSNN LILILLEPIP QNSIPNKYHK
760 770 780 790
LKALMTQRTY LQWPKEKSKR GLFWANIRAA FNMKLTLVTE NNDVKS
Length:796
Mass (Da):91,880
Last modified:May 18, 2010 - v2
Checksum:i9ACEAEC084CB466C
GO
Isoform 2 (identifier: Q9Y2C9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     383-698: Missing.

Note: No experimental confirmation available.
Show »
Length:480
Mass (Da):55,828
Checksum:i5AAB534C449E2D9B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057289120I → T.2 PublicationsCorresponds to variant rs5743808dbSNPEnsembl.1
Natural variantiVAR_066352128L → V Impairs the ability to induce NF-kappa-B activation. 1 PublicationCorresponds to variant rs137853178dbSNPEnsembl.1
Natural variantiVAR_057290194L → P Impairs the ability to induce NF-kappa-B activation. 1 PublicationCorresponds to variant rs5743809dbSNPEnsembl.1
Natural variantiVAR_066353210A → G.1 PublicationCorresponds to variant rs137853180dbSNPEnsembl.1
Natural variantiVAR_066354210A → T.1 PublicationCorresponds to variant rs137853179dbSNPEnsembl.1
Natural variantiVAR_057291247R → K.1 PublicationCorresponds to variant rs35220466dbSNPEnsembl.1
Natural variantiVAR_063110249S → P.5 PublicationsCorresponds to variant rs5743810dbSNPEnsembl.1
Natural variantiVAR_066355283I → V.1 PublicationCorresponds to variant rs137853181dbSNPEnsembl.1
Natural variantiVAR_057292327V → M.2 PublicationsCorresponds to variant rs3796508dbSNPEnsembl.1
Natural variantiVAR_057293345H → Y.Corresponds to variant rs5743813dbSNPEnsembl.1
Natural variantiVAR_057294427V → A.1 PublicationCorresponds to variant rs5743815dbSNPEnsembl.1
Natural variantiVAR_066356442D → A.1 PublicationCorresponds to variant rs137853182dbSNPEnsembl.1
Natural variantiVAR_057295465V → I.1 PublicationCorresponds to variant rs5743816dbSNPEnsembl.1
Natural variantiVAR_057296474A → T.1 PublicationCorresponds to variant rs35762983dbSNPEnsembl.1
Natural variantiVAR_066357474A → V Impairs the ability to induce NF-kappa-B activation. 1 Publication1
Natural variantiVAR_066358592G → V.1 PublicationCorresponds to variant rs75244616dbSNPEnsembl.1
Natural variantiVAR_066359690N → T Impairs the ability to induce NF-kappa-B activation. 1 PublicationCorresponds to variant rs114855575dbSNPEnsembl.1
Natural variantiVAR_066360708Q → H Impairs the ability to induce NF-kappa-B activation. 1 PublicationCorresponds to variant rs137853183dbSNPEnsembl.1
Natural variantiVAR_057297783M → V.Corresponds to variant rs5743822dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056851383 – 698Missing in isoform 2. 1 PublicationAdd BLAST316

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020807 mRNA. Translation: BAA78631.1.
AB445652 mRNA. Translation: BAG55049.1.
EU170528 Genomic DNA. Translation: ABW37063.1.
EU170529 Genomic DNA. Translation: ABW37064.1.
EU170531 Genomic DNA. Translation: ABW37066.1.
EU170532 Genomic DNA. Translation: ABW37067.1.
EU170533 Genomic DNA. Translation: ABW37068.1.
EU170534 Genomic DNA. Translation: ABW37069.1.
EU170536 Genomic DNA. Translation: ABW37071.1.
EU195537 Genomic DNA. Translation: ABY67113.1.
EU195538 Genomic DNA. Translation: ABY67114.1.
EU195539 Genomic DNA. Translation: ABY67115.1.
EU195541 Genomic DNA. Translation: ABY67117.1.
EU195542 Genomic DNA. Translation: ABY67118.1.
EU195543 Genomic DNA. Translation: ABY67119.1.
EU195544 Genomic DNA. Translation: ABY67120.1.
EU195545 Genomic DNA. Translation: ABY67121.1.
EU195546 Genomic DNA. Translation: ABY67122.1.
EU195547 Genomic DNA. Translation: ABY67123.1.
EU195548 Genomic DNA. Translation: ABY67124.1.
EU195550 Genomic DNA. Translation: ABY67126.1.
EU195551 Genomic DNA. Translation: ABY67127.1.
EU195553 Genomic DNA. Translation: ABY67129.1.
EU195554 Genomic DNA. Translation: ABY67130.1.
EU195555 Genomic DNA. Translation: ABY67131.1.
EU195557 Genomic DNA. Translation: ABY67133.1.
AC108044 Genomic DNA. No translation available.
CH471069 Genomic DNA. Translation: EAW92902.1.
BC111755 mRNA. Translation: AAI11756.1.
CCDSiCCDS3446.1. [Q9Y2C9-1]
RefSeqiNP_006059.2. NM_006068.4. [Q9Y2C9-1]
XP_005262694.1. XM_005262637.4. [Q9Y2C9-1]
XP_011511914.1. XM_011513612.2. [Q9Y2C9-1]
XP_011511915.1. XM_011513613.2. [Q9Y2C9-1]
XP_011511916.1. XM_011513614.2. [Q9Y2C9-1]
UniGeneiHs.575090.
Hs.743572.

Genome annotation databases

EnsembliENST00000381950; ENSP00000371376; ENSG00000174130. [Q9Y2C9-1]
ENST00000436693; ENSP00000389600; ENSG00000174130. [Q9Y2C9-1]
ENST00000610323; ENSP00000480266; ENSG00000174130. [Q9Y2C9-2]
GeneIDi10333.
KEGGihsa:10333.
UCSCiuc010ifg.3. human. [Q9Y2C9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020807 mRNA. Translation: BAA78631.1.
AB445652 mRNA. Translation: BAG55049.1.
EU170528 Genomic DNA. Translation: ABW37063.1.
EU170529 Genomic DNA. Translation: ABW37064.1.
EU170531 Genomic DNA. Translation: ABW37066.1.
EU170532 Genomic DNA. Translation: ABW37067.1.
EU170533 Genomic DNA. Translation: ABW37068.1.
EU170534 Genomic DNA. Translation: ABW37069.1.
EU170536 Genomic DNA. Translation: ABW37071.1.
EU195537 Genomic DNA. Translation: ABY67113.1.
EU195538 Genomic DNA. Translation: ABY67114.1.
EU195539 Genomic DNA. Translation: ABY67115.1.
EU195541 Genomic DNA. Translation: ABY67117.1.
EU195542 Genomic DNA. Translation: ABY67118.1.
EU195543 Genomic DNA. Translation: ABY67119.1.
EU195544 Genomic DNA. Translation: ABY67120.1.
EU195545 Genomic DNA. Translation: ABY67121.1.
EU195546 Genomic DNA. Translation: ABY67122.1.
EU195547 Genomic DNA. Translation: ABY67123.1.
EU195548 Genomic DNA. Translation: ABY67124.1.
EU195550 Genomic DNA. Translation: ABY67126.1.
EU195551 Genomic DNA. Translation: ABY67127.1.
EU195553 Genomic DNA. Translation: ABY67129.1.
EU195554 Genomic DNA. Translation: ABY67130.1.
EU195555 Genomic DNA. Translation: ABY67131.1.
EU195557 Genomic DNA. Translation: ABY67133.1.
AC108044 Genomic DNA. No translation available.
CH471069 Genomic DNA. Translation: EAW92902.1.
BC111755 mRNA. Translation: AAI11756.1.
CCDSiCCDS3446.1. [Q9Y2C9-1]
RefSeqiNP_006059.2. NM_006068.4. [Q9Y2C9-1]
XP_005262694.1. XM_005262637.4. [Q9Y2C9-1]
XP_011511914.1. XM_011513612.2. [Q9Y2C9-1]
XP_011511915.1. XM_011513613.2. [Q9Y2C9-1]
XP_011511916.1. XM_011513614.2. [Q9Y2C9-1]
UniGeneiHs.575090.
Hs.743572.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4OM7X-ray2.20A/B640-796[»]
ProteinModelPortaliQ9Y2C9.
SMRiQ9Y2C9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115616. 3 interactors.
STRINGi9606.ENSP00000371376.

Chemistry databases

ChEMBLiCHEMBL3301399.

PTM databases

iPTMnetiQ9Y2C9.
PhosphoSitePlusiQ9Y2C9.

Polymorphism and mutation databases

BioMutaiTLR6.
DMDMi296452933.

Proteomic databases

PaxDbiQ9Y2C9.
PeptideAtlasiQ9Y2C9.
PRIDEiQ9Y2C9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381950; ENSP00000371376; ENSG00000174130. [Q9Y2C9-1]
ENST00000436693; ENSP00000389600; ENSG00000174130. [Q9Y2C9-1]
ENST00000610323; ENSP00000480266; ENSG00000174130. [Q9Y2C9-2]
GeneIDi10333.
KEGGihsa:10333.
UCSCiuc010ifg.3. human. [Q9Y2C9-1]

Organism-specific databases

CTDi10333.
DisGeNETi10333.
GeneCardsiTLR6.
H-InvDBHIX0004160.
HGNCiHGNC:16711. TLR6.
MIMi605403. gene.
neXtProtiNX_Q9Y2C9.
OpenTargetsiENSG00000174130.
PharmGKBiPA38183.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4641. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000119006.
HOGENOMiHOG000008676.
HOVERGENiHBG023180.
InParanoidiQ9Y2C9.
KOiK10169.
OMAiSIPNKYH.
OrthoDBiEOG091G0356.
PhylomeDBiQ9Y2C9.
TreeFamiTF351113.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000174130-MONOMER.
ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-166058. MyD88:Mal cascade initiated on plasma membrane.
R-HSA-168188. Toll Like Receptor TLR6:TLR2 Cascade.
R-HSA-5602498. MyD88 deficiency (TLR2/4).
R-HSA-5603041. IRAK4 deficiency (TLR2/4).
R-HSA-5686938. Regulation of TLR by endogenous ligand.
SIGNORiQ9Y2C9.

Miscellaneous databases

ChiTaRSiTLR6. human.
GeneWikiiTLR6.
GenomeRNAii10333.
PROiQ9Y2C9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000174130.
CleanExiHS_TLR6.
ExpressionAtlasiQ9Y2C9. baseline and differential.
GenevisibleiQ9Y2C9. HS.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
3.80.10.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
IPR027187. TLR6.
IPR017241. Toll-like_receptor.
[Graphical view]
PANTHERiPTHR24365:SF23. PTHR24365:SF23. 1 hit.
PfamiPF13855. LRR_8. 2 hits.
PF01463. LRRCT. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
PIRSFiPIRSF037595. Toll-like_receptor. 1 hit.
SMARTiSM00369. LRR_TYP. 5 hits.
SM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 3 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 9 hits.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTLR6_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2C9
Secondary accession number(s): B3Y640
, B6CH35, B6RFS4, B6RFS5, Q2NKL3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 155 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.