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Q9Y2C9

- TLR6_HUMAN

UniProt

Q9Y2C9 - TLR6_HUMAN

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Protein

Toll-like receptor 6

Gene

TLR6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Participates in the innate immune response to Gram-positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2. In complex with TLR4, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion.2 Publications

GO - Molecular functioni

  1. diacyl lipopeptide binding Source: Ensembl
  2. lipopeptide binding Source: UniProtKB
  3. receptor activity Source: ProtInc
  4. transmembrane signaling receptor activity Source: InterPro

GO - Biological processi

  1. activation of NF-kappaB-inducing kinase activity Source: UniProtKB
  2. cellular response to diacyl bacterial lipopeptide Source: MGI
  3. defense response to bacterium Source: ProtInc
  4. detection of diacyl bacterial lipopeptide Source: MGI
  5. immune response Source: ProtInc
  6. inflammatory response Source: UniProtKB-KW
  7. innate immune response Source: Reactome
  8. microglial cell activation involved in immune response Source: Ensembl
  9. MyD88-dependent toll-like receptor signaling pathway Source: Reactome
  10. nitric oxide metabolic process Source: Ensembl
  11. pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response Source: Ensembl
  12. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: MGI
  13. positive regulation of interleukin-6 biosynthetic process Source: UniProtKB
  14. positive regulation of JUN kinase activity Source: MGI
  15. regulation of cytokine secretion Source: InterPro
  16. signal transduction Source: ProtInc
  17. T-helper 1 type immune response Source: UniProtKB
  18. toll-like receptor 2 signaling pathway Source: Reactome
  19. toll-like receptor 4 signaling pathway Source: Reactome
  20. toll-like receptor 6 signaling pathway Source: InterPro
  21. toll-like receptor signaling pathway Source: Reactome
  22. toll-like receptor TLR1:TLR2 signaling pathway Source: Reactome
  23. toll-like receptor TLR6:TLR2 signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

ReactomeiREACT_6788. MyD88:Mal cascade initiated on plasma membrane.
REACT_8006. Toll Like Receptor TLR6:TLR2 Cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Toll-like receptor 6
Alternative name(s):
CD_antigen: CD286
Gene namesi
Name:TLR6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:16711. TLR6.

Subcellular locationi

Cell membrane 1 Publication; Single-pass type I membrane protein By similarity. Cytoplasmic vesiclephagosome membrane By similarity; Single-pass type I membrane protein By similarity
Note: Upon complex formation with CD36 and TLR4, internalized through dynamin-dependent endocytosis.1 Publication

GO - Cellular componenti

  1. cytoplasmic vesicle Source: UniProtKB-KW
  2. integral component of plasma membrane Source: ProtInc
  3. plasma membrane Source: Reactome
  4. Toll-like receptor 2-Toll-like receptor 6 protein complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38183.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131Sequence AnalysisAdd
BLAST
Chaini32 – 796765Toll-like receptor 6PRO_0000034731Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi117 ↔ 139By similarity
Glycosylationi144 – 1441N-linked (GlcNAc...)Sequence Analysis
Glycosylationi186 – 1861N-linked (GlcNAc...)Sequence Analysis
Glycosylationi214 – 2141N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi235 ↔ 265By similarity
Glycosylationi253 – 2531N-linked (GlcNAc...)Sequence Analysis
Glycosylationi285 – 2851N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi348 ↔ 373By similarity
Glycosylationi359 – 3591N-linked (GlcNAc...)Sequence Analysis
Glycosylationi423 – 4231N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi424 ↔ 447By similarity
Glycosylationi434 – 4341N-linked (GlcNAc...)Sequence Analysis
Glycosylationi583 – 5831N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9Y2C9.
PaxDbiQ9Y2C9.
PRIDEiQ9Y2C9.

PTM databases

PhosphoSiteiQ9Y2C9.

Expressioni

Tissue specificityi

Detected in monocytes, CD11c+ immature dendritic cells, plasmacytoid pre-dendritic cells and dermal microvessel endothelial cells.

Gene expression databases

BgeeiQ9Y2C9.
CleanExiHS_TLR6.
ExpressionAtlasiQ9Y2C9. baseline and differential.
GenevestigatoriQ9Y2C9.

Interactioni

Subunit structurei

Binds MYD88 via their respective TIR domains. Heterodimer with TLR2 via their respective extracellular domains (By similarity). Interacts with CD36, following CD36 stimulation by oxLDL or amyloid-beta 42, and forms a heterodimer with TLR4. The trimeric complex is internalized and triggers inflammatory response. LYN kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation.1 Publication

Protein-protein interaction databases

BioGridi115616. 1 interaction.
STRINGi9606.ENSP00000371376.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4OM7X-ray2.20A/B640-796[»]
ProteinModelPortaliQ9Y2C9.
SMRiQ9Y2C9. Positions 33-786.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini32 – 586555ExtracellularSequence AnalysisAdd
BLAST
Topological domaini608 – 796189CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei587 – 60721HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati54 – 7724LRR 1Add
BLAST
Repeati78 – 10124LRR 2Add
BLAST
Repeati102 – 12221LRR 3Add
BLAST
Repeati123 – 14725LRR 4Add
BLAST
Repeati148 – 16821LRR 5Add
BLAST
Repeati169 – 19628LRR 6Add
BLAST
Repeati197 – 21923LRR 7Add
BLAST
Repeati220 – 25031LRR 8Add
BLAST
Repeati251 – 27727LRR 9Add
BLAST
Repeati278 – 30326LRR 10Add
BLAST
Repeati304 – 33027LRR 11Add
BLAST
Repeati331 – 35424LRR 12Add
BLAST
Repeati355 – 37824LRR 13Add
BLAST
Repeati379 – 40426LRR 14Add
BLAST
Repeati405 – 42925LRR 15Add
BLAST
Repeati430 – 45021LRR 16Add
BLAST
Repeati451 – 47424LRR 17Add
BLAST
Repeati475 – 49622LRR 18Add
BLAST
Repeati497 – 52024LRR 19Add
BLAST
Domaini521 – 57555LRRCTAdd
BLAST
Domaini640 – 784145TIRPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the Toll-like receptor family.Curated
Contains 19 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 TIR domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG272762.
GeneTreeiENSGT00760000119006.
HOGENOMiHOG000008676.
HOVERGENiHBG023180.
InParanoidiQ9Y2C9.
KOiK10169.
OMAiSDTPFIH.
OrthoDBiEOG7GN2M5.
PhylomeDBiQ9Y2C9.
TreeFamiTF351113.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR000157. TIR_dom.
IPR027187. TLR6.
IPR017241. Toll-like_receptor.
[Graphical view]
PANTHERiPTHR24365:SF23. PTHR24365:SF23. 1 hit.
PfamiPF13855. LRR_8. 2 hits.
PF01463. LRRCT. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
PIRSFiPIRSF037595. Toll-like_receptor. 1 hit.
SMARTiSM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 9 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9Y2C9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTKDKEPIVK SFHFVCLMII IVGTRIQFSD GNEFAVDKSK RGLIHVPKDL
60 70 80 90 100
PLKTKVLDMS QNYIAELQVS DMSFLSELTV LRLSHNRIQL LDLSVFKFNQ
110 120 130 140 150
DLEYLDLSHN QLQKISCHPI VSFRHLDLSF NDFKALPICK EFGNLSQLNF
160 170 180 190 200
LGLSAMKLQK LDLLPIAHLH LSYILLDLRN YYIKENETES LQILNAKTLH
210 220 230 240 250
LVFHPTSLFA IQVNISVNTL GCLQLTNIKL NDDNCQVFIK FLSELTRGST
260 270 280 290 300
LLNFTLNHIE TTWKCLVRVF QFLWPKPVEY LNIYNLTIIE SIREEDFTYS
310 320 330 340 350
KTTLKALTIE HITNQVFLFS QTALYTVFSE MNIMMLTISD TPFIHMLCPH
360 370 380 390 400
APSTFKFLNF TQNVFTDSIF EKCSTLVKLE TLILQKNGLK DLFKVGLMTK
410 420 430 440 450
DMPSLEILDV SWNSLESGRH KENCTWVESI VVLNLSSNML TDSVFRCLPP
460 470 480 490 500
RIKVLDLHSN KIKSVPKQVV KLEALQELNV AFNSLTDLPG CGSFSSLSVL
510 520 530 540 550
IIDHNSVSHP SADFFQSCQK MRSIKAGDNP FQCTCELREF VKNIDQVSSE
560 570 580 590 600
VLEGWPDSYK CDYPESYRGS PLKDFHMSEL SCNITLLIVT IGATMLVLAV
610 620 630 640 650
TVTSLCIYLD LPWYLRMVCQ WTQTRRRARN IPLEELQRNL QFHAFISYSE
660 670 680 690 700
HDSAWVKSEL VPYLEKEDIQ ICLHERNFVP GKSIVENIIN CIEKSYKSIF
710 720 730 740 750
VLSPNFVQSE WCHYELYFAH HNLFHEGSNN LILILLEPIP QNSIPNKYHK
760 770 780 790
LKALMTQRTY LQWPKEKSKR GLFWANIRAA FNMKLTLVTE NNDVKS
Length:796
Mass (Da):91,880
Last modified:May 18, 2010 - v2
Checksum:i9ACEAEC084CB466C
GO
Isoform 2 (identifier: Q9Y2C9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     383-698: Missing.

Note: No experimental confirmation available

Show »
Length:480
Mass (Da):55,828
Checksum:i5AAB534C449E2D9B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti120 – 1201I → T.2 Publications
Corresponds to variant rs5743808 [ dbSNP | Ensembl ].
VAR_057289
Natural varianti128 – 1281L → V Impairs the ability to induce NF-kappa-B activation. 1 Publication
Corresponds to variant rs137853178 [ dbSNP | Ensembl ].
VAR_066352
Natural varianti194 – 1941L → P Impairs the ability to induce NF-kappa-B activation. 1 Publication
Corresponds to variant rs5743809 [ dbSNP | Ensembl ].
VAR_057290
Natural varianti210 – 2101A → G.1 Publication
VAR_066353
Natural varianti210 – 2101A → T.1 Publication
VAR_066354
Natural varianti247 – 2471R → K.1 Publication
Corresponds to variant rs35220466 [ dbSNP | Ensembl ].
VAR_057291
Natural varianti249 – 2491S → P.4 Publications
Corresponds to variant rs5743810 [ dbSNP | Ensembl ].
VAR_063110
Natural varianti283 – 2831I → V.1 Publication
VAR_066355
Natural varianti327 – 3271V → M.2 Publications
Corresponds to variant rs3796508 [ dbSNP | Ensembl ].
VAR_057292
Natural varianti345 – 3451H → Y.
Corresponds to variant rs5743813 [ dbSNP | Ensembl ].
VAR_057293
Natural varianti427 – 4271V → A.1 Publication
Corresponds to variant rs5743815 [ dbSNP | Ensembl ].
VAR_057294
Natural varianti442 – 4421D → A.1 Publication
VAR_066356
Natural varianti465 – 4651V → I.1 Publication
Corresponds to variant rs5743816 [ dbSNP | Ensembl ].
VAR_057295
Natural varianti474 – 4741A → T.1 Publication
Corresponds to variant rs35762983 [ dbSNP | Ensembl ].
VAR_057296
Natural varianti474 – 4741A → V Impairs the ability to induce NF-kappa-B activation. 1 Publication
VAR_066357
Natural varianti592 – 5921G → V.1 Publication
Corresponds to variant rs75244616 [ dbSNP | Ensembl ].
VAR_066358
Natural varianti690 – 6901N → T Impairs the ability to induce NF-kappa-B activation. 1 Publication
Corresponds to variant rs114855575 [ dbSNP | Ensembl ].
VAR_066359
Natural varianti708 – 7081Q → H Impairs the ability to induce NF-kappa-B activation. 1 Publication
Corresponds to variant rs137853183 [ dbSNP | Ensembl ].
VAR_066360
Natural varianti783 – 7831M → V.
Corresponds to variant rs5743822 [ dbSNP | Ensembl ].
VAR_057297

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei383 – 698316Missing in isoform 2. 1 PublicationVSP_056851Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB020807 mRNA. Translation: BAA78631.1.
AB445652 mRNA. Translation: BAG55049.1.
EU170528 Genomic DNA. Translation: ABW37063.1.
EU170529 Genomic DNA. Translation: ABW37064.1.
EU170531 Genomic DNA. Translation: ABW37066.1.
EU170532 Genomic DNA. Translation: ABW37067.1.
EU170533 Genomic DNA. Translation: ABW37068.1.
EU170534 Genomic DNA. Translation: ABW37069.1.
EU170536 Genomic DNA. Translation: ABW37071.1.
EU195537 Genomic DNA. Translation: ABY67113.1.
EU195538 Genomic DNA. Translation: ABY67114.1.
EU195539 Genomic DNA. Translation: ABY67115.1.
EU195541 Genomic DNA. Translation: ABY67117.1.
EU195542 Genomic DNA. Translation: ABY67118.1.
EU195543 Genomic DNA. Translation: ABY67119.1.
EU195544 Genomic DNA. Translation: ABY67120.1.
EU195545 Genomic DNA. Translation: ABY67121.1.
EU195546 Genomic DNA. Translation: ABY67122.1.
EU195547 Genomic DNA. Translation: ABY67123.1.
EU195548 Genomic DNA. Translation: ABY67124.1.
EU195550 Genomic DNA. Translation: ABY67126.1.
EU195551 Genomic DNA. Translation: ABY67127.1.
EU195553 Genomic DNA. Translation: ABY67129.1.
EU195554 Genomic DNA. Translation: ABY67130.1.
EU195555 Genomic DNA. Translation: ABY67131.1.
EU195557 Genomic DNA. Translation: ABY67133.1.
AC108044 Genomic DNA. No translation available.
CH471069 Genomic DNA. Translation: EAW92902.1.
BC111755 mRNA. Translation: AAI11756.1.
CCDSiCCDS3446.1.
RefSeqiNP_006059.2. NM_006068.4.
XP_005262693.1. XM_005262636.1.
XP_005262694.1. XM_005262637.2.
UniGeneiHs.575090.
Hs.743572.

Genome annotation databases

EnsembliENST00000381950; ENSP00000371376; ENSG00000174130.
ENST00000436693; ENSP00000389600; ENSG00000174130.
GeneIDi10333.
KEGGihsa:10333.
UCSCiuc003gtm.3. human.

Polymorphism databases

DMDMi296452933.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB020807 mRNA. Translation: BAA78631.1 .
AB445652 mRNA. Translation: BAG55049.1 .
EU170528 Genomic DNA. Translation: ABW37063.1 .
EU170529 Genomic DNA. Translation: ABW37064.1 .
EU170531 Genomic DNA. Translation: ABW37066.1 .
EU170532 Genomic DNA. Translation: ABW37067.1 .
EU170533 Genomic DNA. Translation: ABW37068.1 .
EU170534 Genomic DNA. Translation: ABW37069.1 .
EU170536 Genomic DNA. Translation: ABW37071.1 .
EU195537 Genomic DNA. Translation: ABY67113.1 .
EU195538 Genomic DNA. Translation: ABY67114.1 .
EU195539 Genomic DNA. Translation: ABY67115.1 .
EU195541 Genomic DNA. Translation: ABY67117.1 .
EU195542 Genomic DNA. Translation: ABY67118.1 .
EU195543 Genomic DNA. Translation: ABY67119.1 .
EU195544 Genomic DNA. Translation: ABY67120.1 .
EU195545 Genomic DNA. Translation: ABY67121.1 .
EU195546 Genomic DNA. Translation: ABY67122.1 .
EU195547 Genomic DNA. Translation: ABY67123.1 .
EU195548 Genomic DNA. Translation: ABY67124.1 .
EU195550 Genomic DNA. Translation: ABY67126.1 .
EU195551 Genomic DNA. Translation: ABY67127.1 .
EU195553 Genomic DNA. Translation: ABY67129.1 .
EU195554 Genomic DNA. Translation: ABY67130.1 .
EU195555 Genomic DNA. Translation: ABY67131.1 .
EU195557 Genomic DNA. Translation: ABY67133.1 .
AC108044 Genomic DNA. No translation available.
CH471069 Genomic DNA. Translation: EAW92902.1 .
BC111755 mRNA. Translation: AAI11756.1 .
CCDSi CCDS3446.1.
RefSeqi NP_006059.2. NM_006068.4.
XP_005262693.1. XM_005262636.1.
XP_005262694.1. XM_005262637.2.
UniGenei Hs.575090.
Hs.743572.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4OM7 X-ray 2.20 A/B 640-796 [» ]
ProteinModelPortali Q9Y2C9.
SMRi Q9Y2C9. Positions 33-786.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115616. 1 interaction.
STRINGi 9606.ENSP00000371376.

PTM databases

PhosphoSitei Q9Y2C9.

Polymorphism databases

DMDMi 296452933.

Proteomic databases

MaxQBi Q9Y2C9.
PaxDbi Q9Y2C9.
PRIDEi Q9Y2C9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000381950 ; ENSP00000371376 ; ENSG00000174130 .
ENST00000436693 ; ENSP00000389600 ; ENSG00000174130 .
GeneIDi 10333.
KEGGi hsa:10333.
UCSCi uc003gtm.3. human.

Organism-specific databases

CTDi 10333.
GeneCardsi GC04M038828.
H-InvDB HIX0004160.
HGNCi HGNC:16711. TLR6.
MIMi 605403. gene.
neXtProti NX_Q9Y2C9.
PharmGKBi PA38183.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG272762.
GeneTreei ENSGT00760000119006.
HOGENOMi HOG000008676.
HOVERGENi HBG023180.
InParanoidi Q9Y2C9.
KOi K10169.
OMAi SDTPFIH.
OrthoDBi EOG7GN2M5.
PhylomeDBi Q9Y2C9.
TreeFami TF351113.

Enzyme and pathway databases

Reactomei REACT_6788. MyD88:Mal cascade initiated on plasma membrane.
REACT_8006. Toll Like Receptor TLR6:TLR2 Cascade.

Miscellaneous databases

ChiTaRSi TLR6. human.
GeneWikii TLR6.
GenomeRNAii 10333.
NextBioi 39189.
PROi Q9Y2C9.
SOURCEi Search...

Gene expression databases

Bgeei Q9Y2C9.
CleanExi HS_TLR6.
ExpressionAtlasi Q9Y2C9. baseline and differential.
Genevestigatori Q9Y2C9.

Family and domain databases

Gene3Di 3.40.50.10140. 1 hit.
InterProi IPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR000157. TIR_dom.
IPR027187. TLR6.
IPR017241. Toll-like_receptor.
[Graphical view ]
PANTHERi PTHR24365:SF23. PTHR24365:SF23. 1 hit.
Pfami PF13855. LRR_8. 2 hits.
PF01463. LRRCT. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view ]
PIRSFi PIRSF037595. Toll-like_receptor. 1 hit.
SMARTi SM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view ]
SUPFAMi SSF52200. SSF52200. 1 hit.
PROSITEi PS51450. LRR. 9 hits.
PS50104. TIR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "TLR6: a novel member of an expanding Toll-like receptor family."
    Takeuchi O., Kawai T., Sanjo H., Copeland N.G., Gilbert D.J., Jenkins N.A., Takeda K., Akira S.
    Gene 231:59-65(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Placenta.
  2. "Natural selection in the TLR-related genes in the course of primate evolution."
    Nakajima T., Ohtani H., Satta Y., Uno Y., Akari H., Ishida T., Kimura A.
    Immunogenetics 60:727-735(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT PRO-249.
  3. "The novel allele of toll-like receptor 6 gene."
    Liu Z., Xiao W., Wang J., Li N., Tai Y.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-120 AND PRO-249; MET-327.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PRO-249.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT PRO-249.
  7. "Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling."
    Bulut Y., Faure E., Thomas L., Equils O., Arditi M.
    J. Immunol. 167:987-994(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer."
    Stewart C.R., Stuart L.M., Wilkinson K., van Gils J.M., Deng J., Halle A., Rayner K.J., Boyer L., Zhong R., Frazier W.A., Lacy-Hulbert A., El Khoury J., Golenbock D.T., Moore K.J.
    Nat. Immunol. 11:155-161(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CD36 AND TLR4, SUBCELLULAR LOCATION.
  9. "Functional characterization of naturally occurring genetic variants in the human TLR1-2-6 gene family."
    Ben-Ali M., Corre B., Manry J., Barreiro L.B., Quach H., Boniotto M., Pellegrini S., Quintana-Murci L.
    Hum. Mutat. 32:643-652(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS THR-120; VAL-128; PRO-194; THR-210; GLY-210; LYS-247; PRO-249; VAL-283; MET-327; ALA-427; ALA-442; ILE-465; THR-474; VAL-474; VAL-592; THR-690 AND HIS-708, CHARACTERIZATION OF VARIANTS VAL-128; PRO-194; VAL-474; THR-690 AND HIS-708.

Entry informationi

Entry nameiTLR6_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2C9
Secondary accession number(s): B3Y640
, B6CH35, B6RFS4, B6RFS5, Q2NKL3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: May 18, 2010
Last modified: October 29, 2014
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3