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Q9Y2C9

- TLR6_HUMAN

UniProt

Q9Y2C9 - TLR6_HUMAN

Protein

Toll-like receptor 6

Gene

TLR6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 134 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
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    Functioni

    Participates in the innate immune response to Gram-positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2.1 Publication

    GO - Molecular functioni

    1. diacyl lipopeptide binding Source: Ensembl
    2. lipopeptide binding Source: UniProtKB
    3. receptor activity Source: ProtInc
    4. transmembrane signaling receptor activity Source: InterPro

    GO - Biological processi

    1. activation of NF-kappaB-inducing kinase activity Source: UniProtKB
    2. cellular response to diacyl bacterial lipopeptide Source: MGI
    3. defense response to bacterium Source: ProtInc
    4. detection of diacyl bacterial lipopeptide Source: MGI
    5. immune response Source: ProtInc
    6. inflammatory response Source: UniProtKB-KW
    7. innate immune response Source: Reactome
    8. microglial cell activation involved in immune response Source: Ensembl
    9. MyD88-dependent toll-like receptor signaling pathway Source: Reactome
    10. nitric oxide metabolic process Source: Ensembl
    11. pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response Source: Ensembl
    12. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: MGI
    13. positive regulation of interleukin-6 biosynthetic process Source: UniProtKB
    14. positive regulation of JUN kinase activity Source: MGI
    15. regulation of cytokine secretion Source: InterPro
    16. signal transduction Source: ProtInc
    17. T-helper 1 type immune response Source: UniProtKB
    18. toll-like receptor 2 signaling pathway Source: Reactome
    19. toll-like receptor 4 signaling pathway Source: Reactome
    20. toll-like receptor 6 signaling pathway Source: InterPro
    21. toll-like receptor signaling pathway Source: Reactome
    22. toll-like receptor TLR1:TLR2 signaling pathway Source: Reactome
    23. toll-like receptor TLR6:TLR2 signaling pathway Source: Reactome

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Immunity, Inflammatory response, Innate immunity

    Enzyme and pathway databases

    ReactomeiREACT_6788. MyD88:Mal cascade initiated on plasma membrane.
    REACT_8006. Toll Like Receptor TLR6:TLR2 Cascade.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Toll-like receptor 6
    Alternative name(s):
    CD_antigen: CD286
    Gene namesi
    Name:TLR6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:16711. TLR6.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. phagocytic vesicle membrane Source: UniProtKB-SubCell
    3. plasma membrane Source: Reactome
    4. Toll-like receptor 2-Toll-like receptor 6 protein complex Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Cytoplasmic vesicle, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38183.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3131Sequence AnalysisAdd
    BLAST
    Chaini32 – 796765Toll-like receptor 6PRO_0000034731Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi117 ↔ 139By similarity
    Glycosylationi144 – 1441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi186 – 1861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi214 – 2141N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi235 ↔ 265By similarity
    Glycosylationi253 – 2531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi285 – 2851N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi348 ↔ 373By similarity
    Glycosylationi359 – 3591N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi423 – 4231N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi424 ↔ 447By similarity
    Glycosylationi434 – 4341N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi583 – 5831N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ9Y2C9.
    PaxDbiQ9Y2C9.
    PRIDEiQ9Y2C9.

    PTM databases

    PhosphoSiteiQ9Y2C9.

    Expressioni

    Tissue specificityi

    Detected in monocytes, CD11c+ immature dendritic cells, plasmacytoid pre-dendritic cells and dermal microvessel endothelial cells.

    Gene expression databases

    ArrayExpressiQ9Y2C9.
    BgeeiQ9Y2C9.
    CleanExiHS_TLR6.
    GenevestigatoriQ9Y2C9.

    Interactioni

    Subunit structurei

    Binds MYD88 via their respective TIR domains. Heterodimer with TLR2 via their respective extracellular domains By similarity.By similarity

    Protein-protein interaction databases

    BioGridi115616. 1 interaction.
    STRINGi9606.ENSP00000371376.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y2C9.
    SMRiQ9Y2C9. Positions 33-786.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini32 – 586555ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini608 – 796189CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei587 – 60721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati54 – 7724LRR 1Add
    BLAST
    Repeati78 – 10124LRR 2Add
    BLAST
    Repeati102 – 12221LRR 3Add
    BLAST
    Repeati123 – 14725LRR 4Add
    BLAST
    Repeati148 – 16821LRR 5Add
    BLAST
    Repeati169 – 19628LRR 6Add
    BLAST
    Repeati197 – 21923LRR 7Add
    BLAST
    Repeati220 – 25031LRR 8Add
    BLAST
    Repeati251 – 27727LRR 9Add
    BLAST
    Repeati278 – 30326LRR 10Add
    BLAST
    Repeati304 – 33027LRR 11Add
    BLAST
    Repeati331 – 35424LRR 12Add
    BLAST
    Repeati355 – 37824LRR 13Add
    BLAST
    Repeati379 – 40426LRR 14Add
    BLAST
    Repeati405 – 42925LRR 15Add
    BLAST
    Repeati430 – 45021LRR 16Add
    BLAST
    Repeati451 – 47424LRR 17Add
    BLAST
    Repeati475 – 49622LRR 18Add
    BLAST
    Repeati497 – 52024LRR 19Add
    BLAST
    Domaini521 – 57555LRRCTAdd
    BLAST
    Domaini640 – 784145TIRPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Toll-like receptor family.Curated
    Contains 19 LRR (leucine-rich) repeats.Curated
    Contains 1 LRRCT domain.Curated
    Contains 1 TIR domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG272762.
    HOGENOMiHOG000008676.
    HOVERGENiHBG023180.
    InParanoidiQ9Y2C9.
    KOiK10169.
    OMAiSDTPFIH.
    OrthoDBiEOG7GN2M5.
    PhylomeDBiQ9Y2C9.
    TreeFamiTF351113.

    Family and domain databases

    Gene3Di3.40.50.10140. 1 hit.
    InterProiIPR000483. Cys-rich_flank_reg_C.
    IPR001611. Leu-rich_rpt.
    IPR000157. TIR_dom.
    IPR027187. TLR6.
    IPR017241. Toll-like_receptor.
    [Graphical view]
    PANTHERiPTHR24365:SF23. PTHR24365:SF23. 1 hit.
    PfamiPF13855. LRR_8. 2 hits.
    PF01463. LRRCT. 1 hit.
    PF01582. TIR. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037595. Toll-like_receptor. 1 hit.
    SMARTiSM00082. LRRCT. 1 hit.
    SM00255. TIR. 1 hit.
    [Graphical view]
    SUPFAMiSSF52200. SSF52200. 1 hit.
    PROSITEiPS51450. LRR. 9 hits.
    PS50104. TIR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9Y2C9-1 [UniParc]FASTAAdd to Basket

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    MTKDKEPIVK SFHFVCLMII IVGTRIQFSD GNEFAVDKSK RGLIHVPKDL    50
    PLKTKVLDMS QNYIAELQVS DMSFLSELTV LRLSHNRIQL LDLSVFKFNQ 100
    DLEYLDLSHN QLQKISCHPI VSFRHLDLSF NDFKALPICK EFGNLSQLNF 150
    LGLSAMKLQK LDLLPIAHLH LSYILLDLRN YYIKENETES LQILNAKTLH 200
    LVFHPTSLFA IQVNISVNTL GCLQLTNIKL NDDNCQVFIK FLSELTRGST 250
    LLNFTLNHIE TTWKCLVRVF QFLWPKPVEY LNIYNLTIIE SIREEDFTYS 300
    KTTLKALTIE HITNQVFLFS QTALYTVFSE MNIMMLTISD TPFIHMLCPH 350
    APSTFKFLNF TQNVFTDSIF EKCSTLVKLE TLILQKNGLK DLFKVGLMTK 400
    DMPSLEILDV SWNSLESGRH KENCTWVESI VVLNLSSNML TDSVFRCLPP 450
    RIKVLDLHSN KIKSVPKQVV KLEALQELNV AFNSLTDLPG CGSFSSLSVL 500
    IIDHNSVSHP SADFFQSCQK MRSIKAGDNP FQCTCELREF VKNIDQVSSE 550
    VLEGWPDSYK CDYPESYRGS PLKDFHMSEL SCNITLLIVT IGATMLVLAV 600
    TVTSLCIYLD LPWYLRMVCQ WTQTRRRARN IPLEELQRNL QFHAFISYSE 650
    HDSAWVKSEL VPYLEKEDIQ ICLHERNFVP GKSIVENIIN CIEKSYKSIF 700
    VLSPNFVQSE WCHYELYFAH HNLFHEGSNN LILILLEPIP QNSIPNKYHK 750
    LKALMTQRTY LQWPKEKSKR GLFWANIRAA FNMKLTLVTE NNDVKS 796
    Length:796
    Mass (Da):91,880
    Last modified:May 18, 2010 - v2
    Checksum:i9ACEAEC084CB466C
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti120 – 1201I → T.2 Publications
    Corresponds to variant rs5743808 [ dbSNP | Ensembl ].
    VAR_057289
    Natural varianti128 – 1281L → V Impairs the ability to induce NF-kappa-B activation. 1 Publication
    Corresponds to variant rs137853178 [ dbSNP | Ensembl ].
    VAR_066352
    Natural varianti194 – 1941L → P Impairs the ability to induce NF-kappa-B activation. 1 Publication
    Corresponds to variant rs5743809 [ dbSNP | Ensembl ].
    VAR_057290
    Natural varianti210 – 2101A → G.1 Publication
    VAR_066353
    Natural varianti210 – 2101A → T.1 Publication
    VAR_066354
    Natural varianti247 – 2471R → K.1 Publication
    Corresponds to variant rs35220466 [ dbSNP | Ensembl ].
    VAR_057291
    Natural varianti249 – 2491S → P.4 Publications
    Corresponds to variant rs5743810 [ dbSNP | Ensembl ].
    VAR_063110
    Natural varianti283 – 2831I → V.1 Publication
    VAR_066355
    Natural varianti327 – 3271V → M.2 Publications
    Corresponds to variant rs3796508 [ dbSNP | Ensembl ].
    VAR_057292
    Natural varianti345 – 3451H → Y.
    Corresponds to variant rs5743813 [ dbSNP | Ensembl ].
    VAR_057293
    Natural varianti427 – 4271V → A.1 Publication
    Corresponds to variant rs5743815 [ dbSNP | Ensembl ].
    VAR_057294
    Natural varianti442 – 4421D → A.1 Publication
    VAR_066356
    Natural varianti465 – 4651V → I.1 Publication
    Corresponds to variant rs5743816 [ dbSNP | Ensembl ].
    VAR_057295
    Natural varianti474 – 4741A → T.1 Publication
    Corresponds to variant rs35762983 [ dbSNP | Ensembl ].
    VAR_057296
    Natural varianti474 – 4741A → V Impairs the ability to induce NF-kappa-B activation. 1 Publication
    VAR_066357
    Natural varianti592 – 5921G → V.1 Publication
    Corresponds to variant rs75244616 [ dbSNP | Ensembl ].
    VAR_066358
    Natural varianti690 – 6901N → T Impairs the ability to induce NF-kappa-B activation. 1 Publication
    Corresponds to variant rs114855575 [ dbSNP | Ensembl ].
    VAR_066359
    Natural varianti708 – 7081Q → H Impairs the ability to induce NF-kappa-B activation. 1 Publication
    Corresponds to variant rs137853183 [ dbSNP | Ensembl ].
    VAR_066360
    Natural varianti783 – 7831M → V.
    Corresponds to variant rs5743822 [ dbSNP | Ensembl ].
    VAR_057297

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB020807 mRNA. Translation: BAA78631.1.
    AB445652 mRNA. Translation: BAG55049.1.
    EU170528 Genomic DNA. Translation: ABW37063.1.
    EU170529 Genomic DNA. Translation: ABW37064.1.
    EU170531 Genomic DNA. Translation: ABW37066.1.
    EU170532 Genomic DNA. Translation: ABW37067.1.
    EU170533 Genomic DNA. Translation: ABW37068.1.
    EU170534 Genomic DNA. Translation: ABW37069.1.
    EU170536 Genomic DNA. Translation: ABW37071.1.
    EU195537 Genomic DNA. Translation: ABY67113.1.
    EU195538 Genomic DNA. Translation: ABY67114.1.
    EU195539 Genomic DNA. Translation: ABY67115.1.
    EU195541 Genomic DNA. Translation: ABY67117.1.
    EU195542 Genomic DNA. Translation: ABY67118.1.
    EU195543 Genomic DNA. Translation: ABY67119.1.
    EU195544 Genomic DNA. Translation: ABY67120.1.
    EU195545 Genomic DNA. Translation: ABY67121.1.
    EU195546 Genomic DNA. Translation: ABY67122.1.
    EU195547 Genomic DNA. Translation: ABY67123.1.
    EU195548 Genomic DNA. Translation: ABY67124.1.
    EU195550 Genomic DNA. Translation: ABY67126.1.
    EU195551 Genomic DNA. Translation: ABY67127.1.
    EU195553 Genomic DNA. Translation: ABY67129.1.
    EU195554 Genomic DNA. Translation: ABY67130.1.
    EU195555 Genomic DNA. Translation: ABY67131.1.
    EU195557 Genomic DNA. Translation: ABY67133.1.
    AC108044 Genomic DNA. No translation available.
    CH471069 Genomic DNA. Translation: EAW92902.1.
    CCDSiCCDS3446.1.
    RefSeqiNP_006059.2. NM_006068.4.
    XP_005262693.1. XM_005262636.1.
    XP_005262694.1. XM_005262637.2.
    UniGeneiHs.575090.
    Hs.743572.

    Genome annotation databases

    EnsembliENST00000381950; ENSP00000371376; ENSG00000174130.
    ENST00000436693; ENSP00000389600; ENSG00000174130.
    GeneIDi10333.
    KEGGihsa:10333.
    UCSCiuc003gtm.3. human.

    Polymorphism databases

    DMDMi296452933.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB020807 mRNA. Translation: BAA78631.1 .
    AB445652 mRNA. Translation: BAG55049.1 .
    EU170528 Genomic DNA. Translation: ABW37063.1 .
    EU170529 Genomic DNA. Translation: ABW37064.1 .
    EU170531 Genomic DNA. Translation: ABW37066.1 .
    EU170532 Genomic DNA. Translation: ABW37067.1 .
    EU170533 Genomic DNA. Translation: ABW37068.1 .
    EU170534 Genomic DNA. Translation: ABW37069.1 .
    EU170536 Genomic DNA. Translation: ABW37071.1 .
    EU195537 Genomic DNA. Translation: ABY67113.1 .
    EU195538 Genomic DNA. Translation: ABY67114.1 .
    EU195539 Genomic DNA. Translation: ABY67115.1 .
    EU195541 Genomic DNA. Translation: ABY67117.1 .
    EU195542 Genomic DNA. Translation: ABY67118.1 .
    EU195543 Genomic DNA. Translation: ABY67119.1 .
    EU195544 Genomic DNA. Translation: ABY67120.1 .
    EU195545 Genomic DNA. Translation: ABY67121.1 .
    EU195546 Genomic DNA. Translation: ABY67122.1 .
    EU195547 Genomic DNA. Translation: ABY67123.1 .
    EU195548 Genomic DNA. Translation: ABY67124.1 .
    EU195550 Genomic DNA. Translation: ABY67126.1 .
    EU195551 Genomic DNA. Translation: ABY67127.1 .
    EU195553 Genomic DNA. Translation: ABY67129.1 .
    EU195554 Genomic DNA. Translation: ABY67130.1 .
    EU195555 Genomic DNA. Translation: ABY67131.1 .
    EU195557 Genomic DNA. Translation: ABY67133.1 .
    AC108044 Genomic DNA. No translation available.
    CH471069 Genomic DNA. Translation: EAW92902.1 .
    CCDSi CCDS3446.1.
    RefSeqi NP_006059.2. NM_006068.4.
    XP_005262693.1. XM_005262636.1.
    XP_005262694.1. XM_005262637.2.
    UniGenei Hs.575090.
    Hs.743572.

    3D structure databases

    ProteinModelPortali Q9Y2C9.
    SMRi Q9Y2C9. Positions 33-786.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115616. 1 interaction.
    STRINGi 9606.ENSP00000371376.

    PTM databases

    PhosphoSitei Q9Y2C9.

    Polymorphism databases

    DMDMi 296452933.

    Proteomic databases

    MaxQBi Q9Y2C9.
    PaxDbi Q9Y2C9.
    PRIDEi Q9Y2C9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000381950 ; ENSP00000371376 ; ENSG00000174130 .
    ENST00000436693 ; ENSP00000389600 ; ENSG00000174130 .
    GeneIDi 10333.
    KEGGi hsa:10333.
    UCSCi uc003gtm.3. human.

    Organism-specific databases

    CTDi 10333.
    GeneCardsi GC04M038828.
    H-InvDB HIX0004160.
    HGNCi HGNC:16711. TLR6.
    MIMi 605403. gene.
    neXtProti NX_Q9Y2C9.
    PharmGKBi PA38183.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG272762.
    HOGENOMi HOG000008676.
    HOVERGENi HBG023180.
    InParanoidi Q9Y2C9.
    KOi K10169.
    OMAi SDTPFIH.
    OrthoDBi EOG7GN2M5.
    PhylomeDBi Q9Y2C9.
    TreeFami TF351113.

    Enzyme and pathway databases

    Reactomei REACT_6788. MyD88:Mal cascade initiated on plasma membrane.
    REACT_8006. Toll Like Receptor TLR6:TLR2 Cascade.

    Miscellaneous databases

    ChiTaRSi TLR6. human.
    GeneWikii TLR6.
    GenomeRNAii 10333.
    NextBioi 39189.
    PROi Q9Y2C9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y2C9.
    Bgeei Q9Y2C9.
    CleanExi HS_TLR6.
    Genevestigatori Q9Y2C9.

    Family and domain databases

    Gene3Di 3.40.50.10140. 1 hit.
    InterProi IPR000483. Cys-rich_flank_reg_C.
    IPR001611. Leu-rich_rpt.
    IPR000157. TIR_dom.
    IPR027187. TLR6.
    IPR017241. Toll-like_receptor.
    [Graphical view ]
    PANTHERi PTHR24365:SF23. PTHR24365:SF23. 1 hit.
    Pfami PF13855. LRR_8. 2 hits.
    PF01463. LRRCT. 1 hit.
    PF01582. TIR. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037595. Toll-like_receptor. 1 hit.
    SMARTi SM00082. LRRCT. 1 hit.
    SM00255. TIR. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52200. SSF52200. 1 hit.
    PROSITEi PS51450. LRR. 9 hits.
    PS50104. TIR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "TLR6: a novel member of an expanding Toll-like receptor family."
      Takeuchi O., Kawai T., Sanjo H., Copeland N.G., Gilbert D.J., Jenkins N.A., Takeda K., Akira S.
      Gene 231:59-65(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Placenta.
    2. "Natural selection in the TLR-related genes in the course of primate evolution."
      Nakajima T., Ohtani H., Satta Y., Uno Y., Akari H., Ishida T., Kimura A.
      Immunogenetics 60:727-735(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PRO-249.
    3. "The novel allele of toll-like receptor 6 gene."
      Liu Z., Xiao W., Wang J., Li N., Tai Y.
      Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-120 AND PRO-249; MET-327.
    4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PRO-249.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling."
      Bulut Y., Faure E., Thomas L., Equils O., Arditi M.
      J. Immunol. 167:987-994(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "Functional characterization of naturally occurring genetic variants in the human TLR1-2-6 gene family."
      Ben-Ali M., Corre B., Manry J., Barreiro L.B., Quach H., Boniotto M., Pellegrini S., Quintana-Murci L.
      Hum. Mutat. 32:643-652(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS THR-120; VAL-128; PRO-194; THR-210; GLY-210; LYS-247; PRO-249; VAL-283; MET-327; ALA-427; ALA-442; ILE-465; THR-474; VAL-474; VAL-592; THR-690 AND HIS-708, CHARACTERIZATION OF VARIANTS VAL-128; PRO-194; VAL-474; THR-690 AND HIS-708.

    Entry informationi

    Entry nameiTLR6_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y2C9
    Secondary accession number(s): B3Y640
    , B6CH35, B6RFS4, B6RFS5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 31, 2002
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 134 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3