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Q9Y2C9

- TLR6_HUMAN

UniProt

Q9Y2C9 - TLR6_HUMAN

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Protein

Toll-like receptor 6

Gene
TLR6
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Participates in the innate immune response to Gram-positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2.1 Publication

GO - Molecular functioni

  1. diacyl lipopeptide binding Source: Ensembl
  2. lipopeptide binding Source: UniProtKB
  3. receptor activity Source: ProtInc
  4. transmembrane signaling receptor activity Source: InterPro

GO - Biological processi

  1. activation of NF-kappaB-inducing kinase activity Source: UniProtKB
  2. cellular response to diacyl bacterial lipopeptide Source: MGI
  3. defense response to bacterium Source: ProtInc
  4. detection of diacyl bacterial lipopeptide Source: MGI
  5. immune response Source: ProtInc
  6. inflammatory response Source: UniProtKB-KW
  7. innate immune response Source: Reactome
  8. microglial cell activation involved in immune response Source: Ensembl
  9. MyD88-dependent toll-like receptor signaling pathway Source: Reactome
  10. nitric oxide metabolic process Source: Ensembl
  11. pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response Source: Ensembl
  12. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: MGI
  13. positive regulation of interleukin-6 biosynthetic process Source: UniProtKB
  14. positive regulation of JUN kinase activity Source: MGI
  15. regulation of cytokine secretion Source: InterPro
  16. signal transduction Source: ProtInc
  17. T-helper 1 type immune response Source: UniProtKB
  18. toll-like receptor 2 signaling pathway Source: Reactome
  19. toll-like receptor 4 signaling pathway Source: Reactome
  20. toll-like receptor 6 signaling pathway Source: InterPro
  21. toll-like receptor signaling pathway Source: Reactome
  22. toll-like receptor TLR1:TLR2 signaling pathway Source: Reactome
  23. toll-like receptor TLR6:TLR2 signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

ReactomeiREACT_6788. MyD88:Mal cascade initiated on plasma membrane.
REACT_8006. Toll Like Receptor TLR6:TLR2 Cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Toll-like receptor 6
Alternative name(s):
CD_antigen: CD286
Gene namesi
Name:TLR6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:16711. TLR6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini32 – 586555Extracellular Reviewed predictionAdd
BLAST
Transmembranei587 – 60721Helical; Reviewed predictionAdd
BLAST
Topological domaini608 – 796189Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. phagocytic vesicle membrane Source: UniProtKB-SubCell
  3. plasma membrane Source: Reactome
  4. Toll-like receptor 2-Toll-like receptor 6 protein complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38183.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131 Reviewed predictionAdd
BLAST
Chaini32 – 796765Toll-like receptor 6PRO_0000034731Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi117 ↔ 139 By similarity
Glycosylationi144 – 1441N-linked (GlcNAc...) Reviewed prediction
Glycosylationi186 – 1861N-linked (GlcNAc...) Reviewed prediction
Glycosylationi214 – 2141N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi235 ↔ 265 By similarity
Glycosylationi253 – 2531N-linked (GlcNAc...) Reviewed prediction
Glycosylationi285 – 2851N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi348 ↔ 373 By similarity
Glycosylationi359 – 3591N-linked (GlcNAc...) Reviewed prediction
Glycosylationi423 – 4231N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi424 ↔ 447 By similarity
Glycosylationi434 – 4341N-linked (GlcNAc...) Reviewed prediction
Glycosylationi583 – 5831N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9Y2C9.
PaxDbiQ9Y2C9.
PRIDEiQ9Y2C9.

PTM databases

PhosphoSiteiQ9Y2C9.

Expressioni

Tissue specificityi

Detected in monocytes, CD11c+ immature dendritic cells, plasmacytoid pre-dendritic cells and dermal microvessel endothelial cells.

Gene expression databases

ArrayExpressiQ9Y2C9.
BgeeiQ9Y2C9.
CleanExiHS_TLR6.
GenevestigatoriQ9Y2C9.

Interactioni

Subunit structurei

Binds MYD88 via their respective TIR domains. Heterodimer with TLR2 via their respective extracellular domains By similarity.

Protein-protein interaction databases

BioGridi115616. 1 interaction.
STRINGi9606.ENSP00000371376.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2C9.
SMRiQ9Y2C9. Positions 33-786.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati54 – 7724LRR 1Add
BLAST
Repeati78 – 10124LRR 2Add
BLAST
Repeati102 – 12221LRR 3Add
BLAST
Repeati123 – 14725LRR 4Add
BLAST
Repeati148 – 16821LRR 5Add
BLAST
Repeati169 – 19628LRR 6Add
BLAST
Repeati197 – 21923LRR 7Add
BLAST
Repeati220 – 25031LRR 8Add
BLAST
Repeati251 – 27727LRR 9Add
BLAST
Repeati278 – 30326LRR 10Add
BLAST
Repeati304 – 33027LRR 11Add
BLAST
Repeati331 – 35424LRR 12Add
BLAST
Repeati355 – 37824LRR 13Add
BLAST
Repeati379 – 40426LRR 14Add
BLAST
Repeati405 – 42925LRR 15Add
BLAST
Repeati430 – 45021LRR 16Add
BLAST
Repeati451 – 47424LRR 17Add
BLAST
Repeati475 – 49622LRR 18Add
BLAST
Repeati497 – 52024LRR 19Add
BLAST
Domaini521 – 57555LRRCTAdd
BLAST
Domaini640 – 784145TIRAdd
BLAST

Sequence similaritiesi

Contains 1 LRRCT domain.
Contains 1 TIR domain.

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG272762.
HOGENOMiHOG000008676.
HOVERGENiHBG023180.
InParanoidiQ9Y2C9.
KOiK10169.
OMAiSDTPFIH.
OrthoDBiEOG7GN2M5.
PhylomeDBiQ9Y2C9.
TreeFamiTF351113.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR000157. TIR_dom.
IPR027187. TLR6.
IPR017241. Toll-like_receptor.
[Graphical view]
PANTHERiPTHR24365:SF23. PTHR24365:SF23. 1 hit.
PfamiPF13855. LRR_8. 2 hits.
PF01463. LRRCT. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
PIRSFiPIRSF037595. Toll-like_receptor. 1 hit.
SMARTiSM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 9 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y2C9-1 [UniParc]FASTAAdd to Basket

« Hide

MTKDKEPIVK SFHFVCLMII IVGTRIQFSD GNEFAVDKSK RGLIHVPKDL    50
PLKTKVLDMS QNYIAELQVS DMSFLSELTV LRLSHNRIQL LDLSVFKFNQ 100
DLEYLDLSHN QLQKISCHPI VSFRHLDLSF NDFKALPICK EFGNLSQLNF 150
LGLSAMKLQK LDLLPIAHLH LSYILLDLRN YYIKENETES LQILNAKTLH 200
LVFHPTSLFA IQVNISVNTL GCLQLTNIKL NDDNCQVFIK FLSELTRGST 250
LLNFTLNHIE TTWKCLVRVF QFLWPKPVEY LNIYNLTIIE SIREEDFTYS 300
KTTLKALTIE HITNQVFLFS QTALYTVFSE MNIMMLTISD TPFIHMLCPH 350
APSTFKFLNF TQNVFTDSIF EKCSTLVKLE TLILQKNGLK DLFKVGLMTK 400
DMPSLEILDV SWNSLESGRH KENCTWVESI VVLNLSSNML TDSVFRCLPP 450
RIKVLDLHSN KIKSVPKQVV KLEALQELNV AFNSLTDLPG CGSFSSLSVL 500
IIDHNSVSHP SADFFQSCQK MRSIKAGDNP FQCTCELREF VKNIDQVSSE 550
VLEGWPDSYK CDYPESYRGS PLKDFHMSEL SCNITLLIVT IGATMLVLAV 600
TVTSLCIYLD LPWYLRMVCQ WTQTRRRARN IPLEELQRNL QFHAFISYSE 650
HDSAWVKSEL VPYLEKEDIQ ICLHERNFVP GKSIVENIIN CIEKSYKSIF 700
VLSPNFVQSE WCHYELYFAH HNLFHEGSNN LILILLEPIP QNSIPNKYHK 750
LKALMTQRTY LQWPKEKSKR GLFWANIRAA FNMKLTLVTE NNDVKS 796
Length:796
Mass (Da):91,880
Last modified:May 18, 2010 - v2
Checksum:i9ACEAEC084CB466C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti120 – 1201I → T.2 Publications
Corresponds to variant rs5743808 [ dbSNP | Ensembl ].
VAR_057289
Natural varianti128 – 1281L → V Impairs the ability to induce NF-kappa-B activation. 1 Publication
Corresponds to variant rs137853178 [ dbSNP | Ensembl ].
VAR_066352
Natural varianti194 – 1941L → P Impairs the ability to induce NF-kappa-B activation. 1 Publication
Corresponds to variant rs5743809 [ dbSNP | Ensembl ].
VAR_057290
Natural varianti210 – 2101A → G.1 Publication
VAR_066353
Natural varianti210 – 2101A → T.1 Publication
VAR_066354
Natural varianti247 – 2471R → K.1 Publication
Corresponds to variant rs35220466 [ dbSNP | Ensembl ].
VAR_057291
Natural varianti249 – 2491S → P.4 Publications
Corresponds to variant rs5743810 [ dbSNP | Ensembl ].
VAR_063110
Natural varianti283 – 2831I → V.1 Publication
VAR_066355
Natural varianti327 – 3271V → M.2 Publications
Corresponds to variant rs3796508 [ dbSNP | Ensembl ].
VAR_057292
Natural varianti345 – 3451H → Y.
Corresponds to variant rs5743813 [ dbSNP | Ensembl ].
VAR_057293
Natural varianti427 – 4271V → A.1 Publication
Corresponds to variant rs5743815 [ dbSNP | Ensembl ].
VAR_057294
Natural varianti442 – 4421D → A.1 Publication
VAR_066356
Natural varianti465 – 4651V → I.1 Publication
Corresponds to variant rs5743816 [ dbSNP | Ensembl ].
VAR_057295
Natural varianti474 – 4741A → T.1 Publication
Corresponds to variant rs35762983 [ dbSNP | Ensembl ].
VAR_057296
Natural varianti474 – 4741A → V Impairs the ability to induce NF-kappa-B activation. 1 Publication
VAR_066357
Natural varianti592 – 5921G → V.1 Publication
Corresponds to variant rs75244616 [ dbSNP | Ensembl ].
VAR_066358
Natural varianti690 – 6901N → T Impairs the ability to induce NF-kappa-B activation. 1 Publication
Corresponds to variant rs114855575 [ dbSNP | Ensembl ].
VAR_066359
Natural varianti708 – 7081Q → H Impairs the ability to induce NF-kappa-B activation. 1 Publication
Corresponds to variant rs137853183 [ dbSNP | Ensembl ].
VAR_066360
Natural varianti783 – 7831M → V.
Corresponds to variant rs5743822 [ dbSNP | Ensembl ].
VAR_057297

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB020807 mRNA. Translation: BAA78631.1.
AB445652 mRNA. Translation: BAG55049.1.
EU170528 Genomic DNA. Translation: ABW37063.1.
EU170529 Genomic DNA. Translation: ABW37064.1.
EU170531 Genomic DNA. Translation: ABW37066.1.
EU170532 Genomic DNA. Translation: ABW37067.1.
EU170533 Genomic DNA. Translation: ABW37068.1.
EU170534 Genomic DNA. Translation: ABW37069.1.
EU170536 Genomic DNA. Translation: ABW37071.1.
EU195537 Genomic DNA. Translation: ABY67113.1.
EU195538 Genomic DNA. Translation: ABY67114.1.
EU195539 Genomic DNA. Translation: ABY67115.1.
EU195541 Genomic DNA. Translation: ABY67117.1.
EU195542 Genomic DNA. Translation: ABY67118.1.
EU195543 Genomic DNA. Translation: ABY67119.1.
EU195544 Genomic DNA. Translation: ABY67120.1.
EU195545 Genomic DNA. Translation: ABY67121.1.
EU195546 Genomic DNA. Translation: ABY67122.1.
EU195547 Genomic DNA. Translation: ABY67123.1.
EU195548 Genomic DNA. Translation: ABY67124.1.
EU195550 Genomic DNA. Translation: ABY67126.1.
EU195551 Genomic DNA. Translation: ABY67127.1.
EU195553 Genomic DNA. Translation: ABY67129.1.
EU195554 Genomic DNA. Translation: ABY67130.1.
EU195555 Genomic DNA. Translation: ABY67131.1.
EU195557 Genomic DNA. Translation: ABY67133.1.
AC108044 Genomic DNA. No translation available.
CH471069 Genomic DNA. Translation: EAW92902.1.
CCDSiCCDS3446.1.
RefSeqiNP_006059.2. NM_006068.4.
XP_005262693.1. XM_005262636.1.
XP_005262694.1. XM_005262637.2.
UniGeneiHs.575090.
Hs.743572.

Genome annotation databases

EnsembliENST00000381950; ENSP00000371376; ENSG00000174130.
ENST00000436693; ENSP00000389600; ENSG00000174130.
GeneIDi10333.
KEGGihsa:10333.
UCSCiuc003gtm.3. human.

Polymorphism databases

DMDMi296452933.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB020807 mRNA. Translation: BAA78631.1 .
AB445652 mRNA. Translation: BAG55049.1 .
EU170528 Genomic DNA. Translation: ABW37063.1 .
EU170529 Genomic DNA. Translation: ABW37064.1 .
EU170531 Genomic DNA. Translation: ABW37066.1 .
EU170532 Genomic DNA. Translation: ABW37067.1 .
EU170533 Genomic DNA. Translation: ABW37068.1 .
EU170534 Genomic DNA. Translation: ABW37069.1 .
EU170536 Genomic DNA. Translation: ABW37071.1 .
EU195537 Genomic DNA. Translation: ABY67113.1 .
EU195538 Genomic DNA. Translation: ABY67114.1 .
EU195539 Genomic DNA. Translation: ABY67115.1 .
EU195541 Genomic DNA. Translation: ABY67117.1 .
EU195542 Genomic DNA. Translation: ABY67118.1 .
EU195543 Genomic DNA. Translation: ABY67119.1 .
EU195544 Genomic DNA. Translation: ABY67120.1 .
EU195545 Genomic DNA. Translation: ABY67121.1 .
EU195546 Genomic DNA. Translation: ABY67122.1 .
EU195547 Genomic DNA. Translation: ABY67123.1 .
EU195548 Genomic DNA. Translation: ABY67124.1 .
EU195550 Genomic DNA. Translation: ABY67126.1 .
EU195551 Genomic DNA. Translation: ABY67127.1 .
EU195553 Genomic DNA. Translation: ABY67129.1 .
EU195554 Genomic DNA. Translation: ABY67130.1 .
EU195555 Genomic DNA. Translation: ABY67131.1 .
EU195557 Genomic DNA. Translation: ABY67133.1 .
AC108044 Genomic DNA. No translation available.
CH471069 Genomic DNA. Translation: EAW92902.1 .
CCDSi CCDS3446.1.
RefSeqi NP_006059.2. NM_006068.4.
XP_005262693.1. XM_005262636.1.
XP_005262694.1. XM_005262637.2.
UniGenei Hs.575090.
Hs.743572.

3D structure databases

ProteinModelPortali Q9Y2C9.
SMRi Q9Y2C9. Positions 33-786.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115616. 1 interaction.
STRINGi 9606.ENSP00000371376.

PTM databases

PhosphoSitei Q9Y2C9.

Polymorphism databases

DMDMi 296452933.

Proteomic databases

MaxQBi Q9Y2C9.
PaxDbi Q9Y2C9.
PRIDEi Q9Y2C9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000381950 ; ENSP00000371376 ; ENSG00000174130 .
ENST00000436693 ; ENSP00000389600 ; ENSG00000174130 .
GeneIDi 10333.
KEGGi hsa:10333.
UCSCi uc003gtm.3. human.

Organism-specific databases

CTDi 10333.
GeneCardsi GC04M038828.
H-InvDB HIX0004160.
HGNCi HGNC:16711. TLR6.
MIMi 605403. gene.
neXtProti NX_Q9Y2C9.
PharmGKBi PA38183.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG272762.
HOGENOMi HOG000008676.
HOVERGENi HBG023180.
InParanoidi Q9Y2C9.
KOi K10169.
OMAi SDTPFIH.
OrthoDBi EOG7GN2M5.
PhylomeDBi Q9Y2C9.
TreeFami TF351113.

Enzyme and pathway databases

Reactomei REACT_6788. MyD88:Mal cascade initiated on plasma membrane.
REACT_8006. Toll Like Receptor TLR6:TLR2 Cascade.

Miscellaneous databases

ChiTaRSi TLR6. human.
GeneWikii TLR6.
GenomeRNAii 10333.
NextBioi 39189.
PROi Q9Y2C9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9Y2C9.
Bgeei Q9Y2C9.
CleanExi HS_TLR6.
Genevestigatori Q9Y2C9.

Family and domain databases

Gene3Di 3.40.50.10140. 1 hit.
InterProi IPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR000157. TIR_dom.
IPR027187. TLR6.
IPR017241. Toll-like_receptor.
[Graphical view ]
PANTHERi PTHR24365:SF23. PTHR24365:SF23. 1 hit.
Pfami PF13855. LRR_8. 2 hits.
PF01463. LRRCT. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view ]
PIRSFi PIRSF037595. Toll-like_receptor. 1 hit.
SMARTi SM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view ]
SUPFAMi SSF52200. SSF52200. 1 hit.
PROSITEi PS51450. LRR. 9 hits.
PS50104. TIR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "TLR6: a novel member of an expanding Toll-like receptor family."
    Takeuchi O., Kawai T., Sanjo H., Copeland N.G., Gilbert D.J., Jenkins N.A., Takeda K., Akira S.
    Gene 231:59-65(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  2. "Natural selection in the TLR-related genes in the course of primate evolution."
    Nakajima T., Ohtani H., Satta Y., Uno Y., Akari H., Ishida T., Kimura A.
    Immunogenetics 60:727-735(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PRO-249.
  3. "The novel allele of toll-like receptor 6 gene."
    Liu Z., Xiao W., Wang J., Li N., Tai Y.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-120 AND PRO-249; MET-327.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PRO-249.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling."
    Bulut Y., Faure E., Thomas L., Equils O., Arditi M.
    J. Immunol. 167:987-994(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "Functional characterization of naturally occurring genetic variants in the human TLR1-2-6 gene family."
    Ben-Ali M., Corre B., Manry J., Barreiro L.B., Quach H., Boniotto M., Pellegrini S., Quintana-Murci L.
    Hum. Mutat. 32:643-652(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS THR-120; VAL-128; PRO-194; THR-210; GLY-210; LYS-247; PRO-249; VAL-283; MET-327; ALA-427; ALA-442; ILE-465; THR-474; VAL-474; VAL-592; THR-690 AND HIS-708, CHARACTERIZATION OF VARIANTS VAL-128; PRO-194; VAL-474; THR-690 AND HIS-708.

Entry informationi

Entry nameiTLR6_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2C9
Secondary accession number(s): B3Y640
, B6CH35, B6RFS4, B6RFS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: May 18, 2010
Last modified: September 3, 2014
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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