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Protein

Probable small intestine urate exporter

Gene

SLC17A4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a membrane potential-dependent organic anion transporter, the transport requires a low concentration of chloride ions. May be involved in urate extrusion from the intestinal duct. May recognize hydrophilic anionic drugs such as aspirin, salicylate, and ibuprofen as substrates. Able to actively transport inorganic phosphate into cells via Na+ cotransport (in vitro).1 Publication

GO - Molecular functioni

GO - Biological processi

  • phosphate-containing compound metabolic process Source: ProtInc
  • phosphate ion transmembrane transport Source: GOC
  • sodium-dependent phosphate transport Source: GOC
  • sodium ion transmembrane transport Source: GOC
  • sodium ion transport Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Protein family/group databases

TCDBi2.A.1.14.24. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Probable small intestine urate exporter
Alternative name(s):
Solute carrier family 17 member 4
Gene namesi
Name:SLC17A4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:10932. SLC17A4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei149 – 16921HelicalSequence analysisAdd
BLAST
Transmembranei171 – 19121HelicalSequence analysisAdd
BLAST
Transmembranei203 – 22321HelicalSequence analysisAdd
BLAST
Transmembranei230 – 25021HelicalSequence analysisAdd
BLAST
Transmembranei292 – 31221HelicalSequence analysisAdd
BLAST
Transmembranei332 – 35221HelicalSequence analysisAdd
BLAST
Transmembranei368 – 38821HelicalSequence analysisAdd
BLAST
Transmembranei398 – 41821HelicalSequence analysisAdd
BLAST
Transmembranei431 – 45121HelicalSequence analysisAdd
BLAST
Transmembranei461 – 48121HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • apical plasma membrane Source: UniProtKB-SubCell
  • integral component of plasma membrane Source: ProtInc
  • membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35823.

Polymorphism and mutation databases

BioMutaiSLC17A4.
DMDMi74753468.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 497497Probable small intestine urate exporterPRO_0000318166Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi47 – 471N-linked (GlcNAc...)Sequence analysis
Glycosylationi56 – 561N-linked (GlcNAc...)Sequence analysis
Glycosylationi66 – 661N-linked (GlcNAc...)Sequence analysis
Glycosylationi75 – 751N-linked (GlcNAc...)Sequence analysis
Glycosylationi90 – 901N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9Y2C5.
PaxDbiQ9Y2C5.
PRIDEiQ9Y2C5.

Expressioni

Tissue specificityi

Abundantly expressed in pancreas, liver, colon and small intestine, less in kidney. Not detected in the adrenal glands, brain, placenta, heart, testis, skeletal muscle, and lungs.2 Publications

Gene expression databases

BgeeiQ9Y2C5.
CleanExiHS_SLC17A4.
ExpressionAtlasiQ9Y2C5. baseline and differential.
GenevisibleiQ9Y2C5. HS.

Organism-specific databases

HPAiHPA030179.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000367137.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2C5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2532. Eukaryota.
ENOG410XPWC. LUCA.
GeneTreeiENSGT00760000119079.
HOGENOMiHOG000169313.
HOVERGENiHBG008834.
InParanoidiQ9Y2C5.
KOiK12300.
OMAiSIWVKWA.
OrthoDBiEOG7CK36G.
PhylomeDBiQ9Y2C5.
TreeFamiTF313535.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y2C5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSTGPDVKAT VGDISSDGNL NVAQEECSRK GFCSVRHGLA LILQLCNFSI
60 70 80 90 100
YTQQMNLSIA IPAMVNNTAP PSQPNASTER PSTDSQGYWN ETLKEFKAMA
110 120 130 140 150
PAYDWSPEIQ GIILSSLNYG SFLAPIPSGY VAGIFGAKYV VGAGLFISSF
160 170 180 190 200
LTLFIPLAAN AGVALLIVLR IVQGIAQVMV LTGQYSIWVK WAPPLERSQL
210 220 230 240 250
TTIAGSGSML GSFIVLLAGG LLCQTIGWPY VFYIFGGIGC ACCPLWFPLI
260 270 280 290 300
YDDPVNHPFI SAGEKRYIVC SLAQQDCSPG WSLPIRAMIK SLPLWAILVS
310 320 330 340 350
YFCEYWLFYT IMAYTPTYIS SVLQANLRDS GILSALPFVV GCICIILGGL
360 370 380 390 400
LADFLLSRKI LRLITIRKLF TAIGVLFPSV ILVSLPWVRS SHSMTMTFLV
410 420 430 440 450
LSSAISSFCE SGALVNFLDI APRYTGFLKG LLQVFAHIAG AISPTAAGFF
460 470 480 490
ISQDSEFGWR NVFLLSAAVN ISGLVFYLIF GRADVQDWAK EQTFTHL
Length:497
Mass (Da):54,055
Last modified:November 1, 1999 - v1
Checksum:i5A5616AA52D4990D
GO
Isoform 2 (identifier: Q9Y2C5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: Missing.

Show »
Length:443
Mass (Da):48,270
Checksum:i2D66CDCAC7C927EB
GO
Isoform 3 (identifier: Q9Y2C5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     100-329: Missing.

Note: No experimental confirmation available.
Show »
Length:267
Mass (Da):28,970
Checksum:iB44C45E54D6A3E4B
GO
Isoform 4 (identifier: Q9Y2C5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: Missing.
     100-275: Missing.
     373-373: I → IGKGETGHRGERGKLRAAFSLLCVCPPTP
     424-497: Missing.

Note: No experimental confirmation available.
Show »
Length:221
Mass (Da):24,243
Checksum:i9A4DCE5AE4499ED9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti14 – 141I → T in BAG56870 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti372 – 3721A → T.1 Publication
Corresponds to variant rs11754288 [ dbSNP | Ensembl ].
VAR_038709

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5454Missing in isoform 2 and isoform 4. 1 PublicationVSP_031178Add
BLAST
Alternative sequencei100 – 329230Missing in isoform 3. 1 PublicationVSP_054938Add
BLAST
Alternative sequencei100 – 275176Missing in isoform 4. 1 PublicationVSP_054939Add
BLAST
Alternative sequencei373 – 3731I → IGKGETGHRGERGKLRAAFS LLCVCPPTP in isoform 4. 1 PublicationVSP_054940
Alternative sequencei424 – 49774Missing in isoform 4. 1 PublicationVSP_054941Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020527 mRNA. Translation: BAA76663.1.
AK293354 mRNA. Translation: BAG56870.1.
AL391194 Genomic DNA. Translation: CAD20154.1.
CH471087 Genomic DNA. Translation: EAW55492.1.
BC109207 mRNA. Translation: AAI09208.1.
BC109208 mRNA. Translation: AAI09209.1.
CCDSiCCDS4564.1. [Q9Y2C5-1]
CCDS75411.1. [Q9Y2C5-2]
RefSeqiNP_001273050.1. NM_001286121.1. [Q9Y2C5-2]
NP_005486.1. NM_005495.2. [Q9Y2C5-1]
XP_011512508.1. XM_011514206.1. [Q9Y2C5-1]
XP_011512509.1. XM_011514207.1. [Q9Y2C5-1]
XP_011512510.1. XM_011514208.1. [Q9Y2C5-1]
XP_011512511.1. XM_011514209.1. [Q9Y2C5-1]
XP_011512512.1. XM_011514210.1. [Q9Y2C5-1]
XP_011512513.1. XM_011514211.1. [Q9Y2C5-2]
XP_011512514.1. XM_011514212.1. [Q9Y2C5-2]
XP_011512521.1. XM_011514219.1. [Q9Y2C5-3]
UniGeneiHs.282931.

Genome annotation databases

EnsembliENST00000377905; ENSP00000367137; ENSG00000146039. [Q9Y2C5-1]
ENST00000397076; ENSP00000380266; ENSG00000146039. [Q9Y2C5-4]
ENST00000439485; ENSP00000391345; ENSG00000146039. [Q9Y2C5-2]
GeneIDi10050.
KEGGihsa:10050.
UCSCiuc003nfe.4. human. [Q9Y2C5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020527 mRNA. Translation: BAA76663.1.
AK293354 mRNA. Translation: BAG56870.1.
AL391194 Genomic DNA. Translation: CAD20154.1.
CH471087 Genomic DNA. Translation: EAW55492.1.
BC109207 mRNA. Translation: AAI09208.1.
BC109208 mRNA. Translation: AAI09209.1.
CCDSiCCDS4564.1. [Q9Y2C5-1]
CCDS75411.1. [Q9Y2C5-2]
RefSeqiNP_001273050.1. NM_001286121.1. [Q9Y2C5-2]
NP_005486.1. NM_005495.2. [Q9Y2C5-1]
XP_011512508.1. XM_011514206.1. [Q9Y2C5-1]
XP_011512509.1. XM_011514207.1. [Q9Y2C5-1]
XP_011512510.1. XM_011514208.1. [Q9Y2C5-1]
XP_011512511.1. XM_011514209.1. [Q9Y2C5-1]
XP_011512512.1. XM_011514210.1. [Q9Y2C5-1]
XP_011512513.1. XM_011514211.1. [Q9Y2C5-2]
XP_011512514.1. XM_011514212.1. [Q9Y2C5-2]
XP_011512521.1. XM_011514219.1. [Q9Y2C5-3]
UniGeneiHs.282931.

3D structure databases

ProteinModelPortaliQ9Y2C5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000367137.

Protein family/group databases

TCDBi2.A.1.14.24. the major facilitator superfamily (mfs).

Polymorphism and mutation databases

BioMutaiSLC17A4.
DMDMi74753468.

Proteomic databases

EPDiQ9Y2C5.
PaxDbiQ9Y2C5.
PRIDEiQ9Y2C5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377905; ENSP00000367137; ENSG00000146039. [Q9Y2C5-1]
ENST00000397076; ENSP00000380266; ENSG00000146039. [Q9Y2C5-4]
ENST00000439485; ENSP00000391345; ENSG00000146039. [Q9Y2C5-2]
GeneIDi10050.
KEGGihsa:10050.
UCSCiuc003nfe.4. human. [Q9Y2C5-1]

Organism-specific databases

CTDi10050.
GeneCardsiSLC17A4.
HGNCiHGNC:10932. SLC17A4.
HPAiHPA030179.
MIMi604216. gene.
neXtProtiNX_Q9Y2C5.
PharmGKBiPA35823.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2532. Eukaryota.
ENOG410XPWC. LUCA.
GeneTreeiENSGT00760000119079.
HOGENOMiHOG000169313.
HOVERGENiHBG008834.
InParanoidiQ9Y2C5.
KOiK12300.
OMAiSIWVKWA.
OrthoDBiEOG7CK36G.
PhylomeDBiQ9Y2C5.
TreeFamiTF313535.

Miscellaneous databases

GenomeRNAii10050.
NextBioi35471039.
PROiQ9Y2C5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y2C5.
CleanExiHS_SLC17A4.
ExpressionAtlasiQ9Y2C5. baseline and differential.
GenevisibleiQ9Y2C5. HS.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and chromosomal mapping of a novel human gene showing homology to Na+/PO4 cotransporter."
    Shibui A., Tsunoda T., Seki N., Suzuki Y., Sugane K., Sugano S.
    J. Hum. Genet. 44:190-192(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Small intestine.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Urinary bladder.
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4), VARIANT THR-372.
  6. "A Na+-phosphate cotransporter homologue (SLC17A4 protein) is an intestinal organic anion exporter."
    Togawa N., Miyaji T., Izawa S., Omote H., Moriyama Y.
    Am. J. Physiol. 302:C1652-C1660(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiS17A4_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2C5
Secondary accession number(s): B4DDV9
, E7EPE8, E7EU17, Q32MB7, Q32MB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 1, 1999
Last modified: March 16, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.