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Q9Y2C3

- B3GT5_HUMAN

UniProt

Q9Y2C3 - B3GT5_HUMAN

Protein

Beta-1,3-galactosyltransferase 5

Gene

B3GALT5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Catalyzes the transfer of Gal to GlcNAc-based acceptors with a preference for the core3 O-linked glycan GlcNAc(beta1,3)GalNAc structure. Can use glycolipid LC3Cer as an efficient acceptor.

    Pathwayi

    GO - Molecular functioni

    1. UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity Source: ProtInc

    GO - Biological processi

    1. protein glycosylation Source: ProtInc

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    UniPathwayiUPA00378.

    Protein family/group databases

    CAZyiGT31. Glycosyltransferase Family 31.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-1,3-galactosyltransferase 5 (EC:2.4.1.-)
    Short name:
    Beta-1,3-GalTase 5
    Short name:
    Beta3Gal-T5
    Short name:
    Beta3GalT5
    Short name:
    b3Gal-T5
    Alternative name(s):
    Beta-3-Gx-T5
    UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 5
    UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 5
    Gene namesi
    Name:B3GALT5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 21

    Organism-specific databases

    HGNCiHGNC:920. B3GALT5.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB
    2. Golgi apparatus Source: UniProtKB
    3. Golgi membrane Source: UniProtKB-SubCell
    4. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25213.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 310310Beta-1,3-galactosyltransferase 5PRO_0000219164Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi130 – 1301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi174 – 1741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi231 – 2311N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9Y2C3.
    PeptideAtlasiQ9Y2C3.
    PRIDEiQ9Y2C3.

    Expressioni

    Tissue specificityi

    Expressed in stomach, jejunum, colon, pancreas, small intestine, testis and gastrointestinal and pancreatic cancer cell lines. Hardly detected in lung, liver, adrenal gland and peripheral blood leukocytes.

    Gene expression databases

    BgeeiQ9Y2C3.
    CleanExiHS_B3GALT5.
    GenevestigatoriQ9Y2C3.

    Organism-specific databases

    HPAiHPA054092.
    HPA054684.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000343318.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y2C3.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 77CytoplasmicSequence Analysis
    Topological domaini29 – 310282LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei8 – 2821Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 31 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG293774.
    HOVERGENiHBG094868.
    InParanoidiQ9Y2C3.
    KOiK03877.
    OMAiRFCPQAA.
    OrthoDBiEOG7M3J0F.
    PhylomeDBiQ9Y2C3.
    TreeFamiTF318639.

    Family and domain databases

    InterProiIPR002659. Glyco_trans_31.
    [Graphical view]
    PANTHERiPTHR11214. PTHR11214. 1 hit.
    PfamiPF01762. Galactosyl_T. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Y2C3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAFPKMRLMY ICLLVLGALC LYFSMYSLNP FKEQSFVYKK DGNFLKLPDT    50
    DCRQTPPFLV LLVTSSHKQL AERMAIRQTW GKERMVKGKQ LKTFFLLGTT 100
    SSAAETKEVD QESQRHGDII QKDFLDVYYN LTLKTMMGIE WVHRFCPQAA 150
    FVMKTDSDMF INVDYLTELL LKKNRTTRFF TGFLKLNEFP IRQPFSKWFV 200
    SKSEYPWDRY PPFCSGTGYV FSGDVASQVY NVSKSVPYIK LEDVFVGLCL 250
    ERLNIRLEEL HSQPTFFPGG LRFSVCLFRR IVACHFIKPR TLLDYWQALE 300
    NSRGEDCPPV 310
    Length:310
    Mass (Da):36,189
    Last modified:November 1, 1999 - v1
    Checksum:i4DD7A19E3E648AA9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti23 – 231F → Y in CAB91547. 1 PublicationCurated
    Sequence conflicti26 – 261Y → N in CAB91547. 1 PublicationCurated
    Sequence conflicti293 – 2975LDYWQ → WTTGR in BAA94498. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti27 – 271S → R.
    Corresponds to variant rs12627708 [ dbSNP | Ensembl ].
    VAR_049347
    Natural varianti85 – 851M → T.5 Publications
    Corresponds to variant rs3746887 [ dbSNP | Ensembl ].
    VAR_020460
    Natural varianti144 – 1441R → H.
    Corresponds to variant rs734411 [ dbSNP | Ensembl ].
    VAR_033536

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB020337 mRNA. Translation: BAA77664.1.
    AF145784 Genomic DNA. Translation: AAF07880.1.
    AJ006078 Genomic DNA. Translation: CAB91547.1.
    AY372061 mRNA. Translation: AAR08910.1.
    AK292951 mRNA. Translation: BAF85640.1.
    AL163280 Genomic DNA. Translation: CAB90446.1.
    CH471079 Genomic DNA. Translation: EAX09629.1.
    CH471079 Genomic DNA. Translation: EAX09630.1.
    CH471079 Genomic DNA. Translation: EAX09631.1.
    CH471079 Genomic DNA. Translation: EAX09632.1.
    BC104862 mRNA. Translation: AAI04863.1.
    BC104864 mRNA. Translation: AAI04865.1.
    AB041413 Genomic DNA. Translation: BAA94498.1.
    AB041416 Genomic DNA. Translation: BAA94501.1.
    CCDSiCCDS13667.1.
    RefSeqiNP_001265579.1. NM_001278650.1.
    NP_006048.1. NM_006057.2.
    NP_149360.1. NM_033170.2.
    NP_149361.1. NM_033171.2.
    NP_149362.2. NM_033172.2.
    XP_005260969.1. XM_005260912.1.
    UniGeneiHs.733638.

    Genome annotation databases

    EnsembliENST00000343118; ENSP00000343318; ENSG00000183778.
    ENST00000380618; ENSP00000369992; ENSG00000183778.
    ENST00000380620; ENSP00000369994; ENSG00000183778.
    ENST00000398714; ENSP00000381699; ENSG00000183778.
    GeneIDi10317.
    KEGGihsa:10317.
    UCSCiuc002yyb.1. human.

    Polymorphism databases

    DMDMi13123995.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    GGDB

    GlycoGene database

    Functional Glycomics Gateway - GTase

    Beta-1,3-galactosyltransferase 5

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB020337 mRNA. Translation: BAA77664.1 .
    AF145784 Genomic DNA. Translation: AAF07880.1 .
    AJ006078 Genomic DNA. Translation: CAB91547.1 .
    AY372061 mRNA. Translation: AAR08910.1 .
    AK292951 mRNA. Translation: BAF85640.1 .
    AL163280 Genomic DNA. Translation: CAB90446.1 .
    CH471079 Genomic DNA. Translation: EAX09629.1 .
    CH471079 Genomic DNA. Translation: EAX09630.1 .
    CH471079 Genomic DNA. Translation: EAX09631.1 .
    CH471079 Genomic DNA. Translation: EAX09632.1 .
    BC104862 mRNA. Translation: AAI04863.1 .
    BC104864 mRNA. Translation: AAI04865.1 .
    AB041413 Genomic DNA. Translation: BAA94498.1 .
    AB041416 Genomic DNA. Translation: BAA94501.1 .
    CCDSi CCDS13667.1.
    RefSeqi NP_001265579.1. NM_001278650.1.
    NP_006048.1. NM_006057.2.
    NP_149360.1. NM_033170.2.
    NP_149361.1. NM_033171.2.
    NP_149362.2. NM_033172.2.
    XP_005260969.1. XM_005260912.1.
    UniGenei Hs.733638.

    3D structure databases

    ProteinModelPortali Q9Y2C3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000343318.

    Chemistry

    ChEMBLi CHEMBL2321635.

    Protein family/group databases

    CAZyi GT31. Glycosyltransferase Family 31.

    Polymorphism databases

    DMDMi 13123995.

    Proteomic databases

    PaxDbi Q9Y2C3.
    PeptideAtlasi Q9Y2C3.
    PRIDEi Q9Y2C3.

    Protocols and materials databases

    DNASUi 10317.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000343118 ; ENSP00000343318 ; ENSG00000183778 .
    ENST00000380618 ; ENSP00000369992 ; ENSG00000183778 .
    ENST00000380620 ; ENSP00000369994 ; ENSG00000183778 .
    ENST00000398714 ; ENSP00000381699 ; ENSG00000183778 .
    GeneIDi 10317.
    KEGGi hsa:10317.
    UCSCi uc002yyb.1. human.

    Organism-specific databases

    CTDi 10317.
    GeneCardsi GC21P040928.
    HGNCi HGNC:920. B3GALT5.
    HPAi HPA054092.
    HPA054684.
    MIMi 604066. gene.
    neXtProti NX_Q9Y2C3.
    PharmGKBi PA25213.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG293774.
    HOVERGENi HBG094868.
    InParanoidi Q9Y2C3.
    KOi K03877.
    OMAi RFCPQAA.
    OrthoDBi EOG7M3J0F.
    PhylomeDBi Q9Y2C3.
    TreeFami TF318639.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .

    Miscellaneous databases

    GeneWikii B3GALT5.
    GenomeRNAii 10317.
    NextBioi 39103.
    PROi Q9Y2C3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9Y2C3.
    CleanExi HS_B3GALT5.
    Genevestigatori Q9Y2C3.

    Family and domain databases

    InterProi IPR002659. Glyco_trans_31.
    [Graphical view ]
    PANTHERi PTHR11214. PTHR11214. 1 hit.
    Pfami PF01762. Galactosyl_T. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, expression, and characterization of a novel UDP-galactose:beta-N-acetylglucosamine beta1,3-galactosyltransferase (beta3Gal-T5) responsible for synthesis of type 1 chain in colorectal and pancreatic epithelia and tumor cells derived therefrom."
      Isshiki S., Togayachi A., Kudo T., Nishihara S., Watanabe M., Kubota T., Kitajima M., Shiraishi N., Sasaki K., Andoh T., Narimatsu H.
      J. Biol. Chem. 274:12499-12507(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Colon adenocarcinoma.
    2. "Molecular cloning of a human UDP-galactose:GlcNAcbeta1,3GalNAc beta1, 3 galactosyltransferase gene encoding an O-linked core3-elongation enzyme."
      Zhou D., Berger E.G., Hennet T.
      Eur. J. Biochem. 263:571-576(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Cloning and expression of two beta-1,3-galactosyltransferases: beta3gal-T5 and beta3gal-T6."
      Amado M., Carneiro F., Clausen H.
      Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-85.
    4. "An endogenous retroviral long terminal repeat is the dominant promoter for human beta1,3-galactosyltransferase 5 in the colon."
      Dunn C.A., Medstrand P., Mager D.L.
      Proc. Natl. Acad. Sci. U.S.A. 100:12841-12846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-85.
      Tissue: Trachea.
    6. "The DNA sequence of human chromosome 21."
      Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
      , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
      Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT THR-85.
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-85.
      Tissue: Colon.
    9. Liu Y., Saitou N.
      Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-298, VARIANT THR-85.
    10. "Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions."
      Amado M., Almeida R., Schwientek T., Clausen H.
      Biochim. Biophys. Acta 1473:35-53(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiB3GT5_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y2C3
    Secondary accession number(s): A8KA86
    , D3DSI3, Q2M3L5, Q53Z19, Q9NY96, Q9P1X6, Q9P1X7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 21
      Human chromosome 21: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3