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Protein

Beta-1,3-galactosyltransferase 5

Gene

B3GALT5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the transfer of Gal to GlcNAc-based acceptors with a preference for the core3 O-linked glycan GlcNAc(beta1,3)GalNAc structure. Can use glycolipid LC3Cer as an efficient acceptor.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

  • UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity Source: ProtInc

GO - Biological processi

  • protein glycosylation Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT31. Glycosyltransferase Family 31.

Chemistry databases

SwissLipidsiSLP:000000844.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-1,3-galactosyltransferase 5 (EC:2.4.1.-)
Short name:
Beta-1,3-GalTase 5
Short name:
Beta3Gal-T5
Short name:
Beta3GalT5
Short name:
b3Gal-T5
Alternative name(s):
Beta-3-Gx-T5
UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 5
UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 5
Gene namesi
Name:B3GALT5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:920. B3GALT5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7CytoplasmicSequence analysis7
Transmembranei8 – 28Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini29 – 310LumenalSequence analysisAdd BLAST282

GO - Cellular componenti

  • endoplasmic reticulum Source: UniProtKB
  • Golgi apparatus Source: UniProtKB
  • Golgi membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10317.
OpenTargetsiENSG00000183778.
PharmGKBiPA25213.

Chemistry databases

ChEMBLiCHEMBL2321635.

Polymorphism and mutation databases

BioMutaiB3GALT5.
DMDMi13123995.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002191641 – 310Beta-1,3-galactosyltransferase 5Add BLAST310

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi130N-linked (GlcNAc...)Sequence analysis1
Glycosylationi174N-linked (GlcNAc...)Sequence analysis1
Glycosylationi231N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9Y2C3.
PaxDbiQ9Y2C3.
PeptideAtlasiQ9Y2C3.
PRIDEiQ9Y2C3.

PTM databases

iPTMnetiQ9Y2C3.
PhosphoSitePlusiQ9Y2C3.

Expressioni

Tissue specificityi

Expressed in stomach, jejunum, colon, pancreas, small intestine, testis and gastrointestinal and pancreatic cancer cell lines. Hardly detected in lung, liver, adrenal gland and peripheral blood leukocytes.

Gene expression databases

BgeeiENSG00000183778.
CleanExiHS_B3GALT5.
ExpressionAtlasiQ9Y2C3. baseline and differential.
GenevisibleiQ9Y2C3. HS.

Organism-specific databases

HPAiHPA054092.
HPA054684.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000343318.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2C3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 31 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2287. Eukaryota.
ENOG410ZZ1B. LUCA.
GeneTreeiENSGT00760000118879.
HOVERGENiHBG094868.
InParanoidiQ9Y2C3.
KOiK03877.
PhylomeDBiQ9Y2C3.
TreeFamiTF318639.

Family and domain databases

InterProiIPR002659. Glyco_trans_31.
[Graphical view]
PANTHERiPTHR11214. PTHR11214. 1 hit.
PfamiPF01762. Galactosyl_T. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y2C3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFPKMRLMY ICLLVLGALC LYFSMYSLNP FKEQSFVYKK DGNFLKLPDT
60 70 80 90 100
DCRQTPPFLV LLVTSSHKQL AERMAIRQTW GKERMVKGKQ LKTFFLLGTT
110 120 130 140 150
SSAAETKEVD QESQRHGDII QKDFLDVYYN LTLKTMMGIE WVHRFCPQAA
160 170 180 190 200
FVMKTDSDMF INVDYLTELL LKKNRTTRFF TGFLKLNEFP IRQPFSKWFV
210 220 230 240 250
SKSEYPWDRY PPFCSGTGYV FSGDVASQVY NVSKSVPYIK LEDVFVGLCL
260 270 280 290 300
ERLNIRLEEL HSQPTFFPGG LRFSVCLFRR IVACHFIKPR TLLDYWQALE
310
NSRGEDCPPV
Length:310
Mass (Da):36,189
Last modified:November 1, 1999 - v1
Checksum:i4DD7A19E3E648AA9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23F → Y in CAB91547 (Ref. 3) Curated1
Sequence conflicti26Y → N in CAB91547 (Ref. 3) Curated1
Sequence conflicti293 – 297LDYWQ → WTTGR in BAA94498 (Ref. 9) Curated5

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04934727S → R.Corresponds to variant rs12627708dbSNPEnsembl.1
Natural variantiVAR_02046085M → T.5 PublicationsCorresponds to variant rs3746887dbSNPEnsembl.1
Natural variantiVAR_033536144R → H.Corresponds to variant rs734411dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020337 mRNA. Translation: BAA77664.1.
AF145784 Genomic DNA. Translation: AAF07880.1.
AJ006078 Genomic DNA. Translation: CAB91547.1.
AY372061 mRNA. Translation: AAR08910.1.
AK292951 mRNA. Translation: BAF85640.1.
AL163280 Genomic DNA. Translation: CAB90446.1.
CH471079 Genomic DNA. Translation: EAX09629.1.
CH471079 Genomic DNA. Translation: EAX09630.1.
CH471079 Genomic DNA. Translation: EAX09631.1.
CH471079 Genomic DNA. Translation: EAX09632.1.
BC104862 mRNA. Translation: AAI04863.1.
BC104864 mRNA. Translation: AAI04865.1.
AB041413 Genomic DNA. Translation: BAA94498.1.
AB041416 Genomic DNA. Translation: BAA94501.1.
CCDSiCCDS13667.1.
RefSeqiNP_001265579.1. NM_001278650.1.
NP_006048.1. NM_006057.2.
NP_149360.1. NM_033170.2.
NP_149361.1. NM_033171.2.
NP_149362.2. NM_033172.2.
XP_016883716.1. XM_017028227.1.
XP_016883717.1. XM_017028228.1.
XP_016883718.1. XM_017028229.1.
XP_016883719.1. XM_017028230.1.
XP_016883720.1. XM_017028231.1.
XP_016883721.1. XM_017028232.1.
XP_016883722.1. XM_017028233.1.
XP_016883723.1. XM_017028234.1.
XP_016883724.1. XM_017028235.1.
XP_016883725.1. XM_017028236.1.
XP_016883726.1. XM_017028237.1.
XP_016883727.1. XM_017028238.1.
XP_016883728.1. XM_017028239.1.
XP_016883729.1. XM_017028240.1.
XP_016883730.1. XM_017028241.1.
UniGeneiHs.733638.

Genome annotation databases

EnsembliENST00000343118; ENSP00000343318; ENSG00000183778.
ENST00000380618; ENSP00000369992; ENSG00000183778.
ENST00000380620; ENSP00000369994; ENSG00000183778.
ENST00000615480; ENSP00000480285; ENSG00000183778.
GeneIDi10317.
KEGGihsa:10317.
UCSCiuc002yyb.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - GTase

Beta-1,3-galactosyltransferase 5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020337 mRNA. Translation: BAA77664.1.
AF145784 Genomic DNA. Translation: AAF07880.1.
AJ006078 Genomic DNA. Translation: CAB91547.1.
AY372061 mRNA. Translation: AAR08910.1.
AK292951 mRNA. Translation: BAF85640.1.
AL163280 Genomic DNA. Translation: CAB90446.1.
CH471079 Genomic DNA. Translation: EAX09629.1.
CH471079 Genomic DNA. Translation: EAX09630.1.
CH471079 Genomic DNA. Translation: EAX09631.1.
CH471079 Genomic DNA. Translation: EAX09632.1.
BC104862 mRNA. Translation: AAI04863.1.
BC104864 mRNA. Translation: AAI04865.1.
AB041413 Genomic DNA. Translation: BAA94498.1.
AB041416 Genomic DNA. Translation: BAA94501.1.
CCDSiCCDS13667.1.
RefSeqiNP_001265579.1. NM_001278650.1.
NP_006048.1. NM_006057.2.
NP_149360.1. NM_033170.2.
NP_149361.1. NM_033171.2.
NP_149362.2. NM_033172.2.
XP_016883716.1. XM_017028227.1.
XP_016883717.1. XM_017028228.1.
XP_016883718.1. XM_017028229.1.
XP_016883719.1. XM_017028230.1.
XP_016883720.1. XM_017028231.1.
XP_016883721.1. XM_017028232.1.
XP_016883722.1. XM_017028233.1.
XP_016883723.1. XM_017028234.1.
XP_016883724.1. XM_017028235.1.
XP_016883725.1. XM_017028236.1.
XP_016883726.1. XM_017028237.1.
XP_016883727.1. XM_017028238.1.
XP_016883728.1. XM_017028239.1.
XP_016883729.1. XM_017028240.1.
XP_016883730.1. XM_017028241.1.
UniGeneiHs.733638.

3D structure databases

ProteinModelPortaliQ9Y2C3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000343318.

Chemistry databases

ChEMBLiCHEMBL2321635.
SwissLipidsiSLP:000000844.

Protein family/group databases

CAZyiGT31. Glycosyltransferase Family 31.

PTM databases

iPTMnetiQ9Y2C3.
PhosphoSitePlusiQ9Y2C3.

Polymorphism and mutation databases

BioMutaiB3GALT5.
DMDMi13123995.

Proteomic databases

EPDiQ9Y2C3.
PaxDbiQ9Y2C3.
PeptideAtlasiQ9Y2C3.
PRIDEiQ9Y2C3.

Protocols and materials databases

DNASUi10317.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343118; ENSP00000343318; ENSG00000183778.
ENST00000380618; ENSP00000369992; ENSG00000183778.
ENST00000380620; ENSP00000369994; ENSG00000183778.
ENST00000615480; ENSP00000480285; ENSG00000183778.
GeneIDi10317.
KEGGihsa:10317.
UCSCiuc002yyb.3. human.

Organism-specific databases

CTDi10317.
DisGeNETi10317.
GeneCardsiB3GALT5.
HGNCiHGNC:920. B3GALT5.
HPAiHPA054092.
HPA054684.
MIMi604066. gene.
neXtProtiNX_Q9Y2C3.
OpenTargetsiENSG00000183778.
PharmGKBiPA25213.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2287. Eukaryota.
ENOG410ZZ1B. LUCA.
GeneTreeiENSGT00760000118879.
HOVERGENiHBG094868.
InParanoidiQ9Y2C3.
KOiK03877.
PhylomeDBiQ9Y2C3.
TreeFamiTF318639.

Enzyme and pathway databases

UniPathwayiUPA00378.

Miscellaneous databases

GeneWikiiB3GALT5.
GenomeRNAii10317.
PROiQ9Y2C3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183778.
CleanExiHS_B3GALT5.
ExpressionAtlasiQ9Y2C3. baseline and differential.
GenevisibleiQ9Y2C3. HS.

Family and domain databases

InterProiIPR002659. Glyco_trans_31.
[Graphical view]
PANTHERiPTHR11214. PTHR11214. 1 hit.
PfamiPF01762. Galactosyl_T. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB3GT5_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2C3
Secondary accession number(s): A8KA86
, D3DSI3, Q2M3L5, Q53Z19, Q9NY96, Q9P1X6, Q9P1X7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.