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Q9Y2C3

- B3GT5_HUMAN

UniProt

Q9Y2C3 - B3GT5_HUMAN

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Protein

Beta-1,3-galactosyltransferase 5

Gene
B3GALT5
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the transfer of Gal to GlcNAc-based acceptors with a preference for the core3 O-linked glycan GlcNAc(beta1,3)GalNAc structure. Can use glycolipid LC3Cer as an efficient acceptor.

Pathwayi

GO - Molecular functioni

  1. UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity Source: ProtInc

GO - Biological processi

  1. protein glycosylation Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT31. Glycosyltransferase Family 31.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-1,3-galactosyltransferase 5 (EC:2.4.1.-)
Short name:
Beta-1,3-GalTase 5
Short name:
Beta3Gal-T5
Short name:
Beta3GalT5
Short name:
b3Gal-T5
Alternative name(s):
Beta-3-Gx-T5
UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 5
UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 5
Gene namesi
Name:B3GALT5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 21

Organism-specific databases

HGNCiHGNC:920. B3GALT5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77Cytoplasmic Reviewed prediction
Transmembranei8 – 2821Helical; Signal-anchor for type II membrane protein; Reviewed predictionAdd
BLAST
Topological domaini29 – 310282Lumenal Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB
  2. Golgi apparatus Source: UniProtKB
  3. Golgi membrane Source: UniProtKB-SubCell
  4. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25213.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310Beta-1,3-galactosyltransferase 5PRO_0000219164Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi130 – 1301N-linked (GlcNAc...) Reviewed prediction
Glycosylationi174 – 1741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi231 – 2311N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9Y2C3.
PeptideAtlasiQ9Y2C3.
PRIDEiQ9Y2C3.

Expressioni

Tissue specificityi

Expressed in stomach, jejunum, colon, pancreas, small intestine, testis and gastrointestinal and pancreatic cancer cell lines. Hardly detected in lung, liver, adrenal gland and peripheral blood leukocytes.

Gene expression databases

BgeeiQ9Y2C3.
CleanExiHS_B3GALT5.
GenevestigatoriQ9Y2C3.

Organism-specific databases

HPAiHPA054092.
HPA054684.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000343318.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2C3.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG293774.
HOVERGENiHBG094868.
InParanoidiQ9Y2C3.
KOiK03877.
OMAiRFCPQAA.
OrthoDBiEOG7M3J0F.
PhylomeDBiQ9Y2C3.
TreeFamiTF318639.

Family and domain databases

InterProiIPR002659. Glyco_trans_31.
[Graphical view]
PANTHERiPTHR11214. PTHR11214. 1 hit.
PfamiPF01762. Galactosyl_T. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y2C3-1 [UniParc]FASTAAdd to Basket

« Hide

MAFPKMRLMY ICLLVLGALC LYFSMYSLNP FKEQSFVYKK DGNFLKLPDT    50
DCRQTPPFLV LLVTSSHKQL AERMAIRQTW GKERMVKGKQ LKTFFLLGTT 100
SSAAETKEVD QESQRHGDII QKDFLDVYYN LTLKTMMGIE WVHRFCPQAA 150
FVMKTDSDMF INVDYLTELL LKKNRTTRFF TGFLKLNEFP IRQPFSKWFV 200
SKSEYPWDRY PPFCSGTGYV FSGDVASQVY NVSKSVPYIK LEDVFVGLCL 250
ERLNIRLEEL HSQPTFFPGG LRFSVCLFRR IVACHFIKPR TLLDYWQALE 300
NSRGEDCPPV 310
Length:310
Mass (Da):36,189
Last modified:November 1, 1999 - v1
Checksum:i4DD7A19E3E648AA9
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti27 – 271S → R.
Corresponds to variant rs12627708 [ dbSNP | Ensembl ].
VAR_049347
Natural varianti85 – 851M → T.5 Publications
Corresponds to variant rs3746887 [ dbSNP | Ensembl ].
VAR_020460
Natural varianti144 – 1441R → H.
Corresponds to variant rs734411 [ dbSNP | Ensembl ].
VAR_033536

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti23 – 231F → Y in CAB91547. 1 Publication
Sequence conflicti26 – 261Y → N in CAB91547. 1 Publication
Sequence conflicti293 – 2975LDYWQ → WTTGR in BAA94498. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB020337 mRNA. Translation: BAA77664.1.
AF145784 Genomic DNA. Translation: AAF07880.1.
AJ006078 Genomic DNA. Translation: CAB91547.1.
AY372061 mRNA. Translation: AAR08910.1.
AK292951 mRNA. Translation: BAF85640.1.
AL163280 Genomic DNA. Translation: CAB90446.1.
CH471079 Genomic DNA. Translation: EAX09629.1.
CH471079 Genomic DNA. Translation: EAX09630.1.
CH471079 Genomic DNA. Translation: EAX09631.1.
CH471079 Genomic DNA. Translation: EAX09632.1.
BC104862 mRNA. Translation: AAI04863.1.
BC104864 mRNA. Translation: AAI04865.1.
AB041413 Genomic DNA. Translation: BAA94498.1.
AB041416 Genomic DNA. Translation: BAA94501.1.
CCDSiCCDS13667.1.
RefSeqiNP_001265579.1. NM_001278650.1.
NP_006048.1. NM_006057.2.
NP_149360.1. NM_033170.2.
NP_149361.1. NM_033171.2.
NP_149362.2. NM_033172.2.
XP_005260969.1. XM_005260912.1.
UniGeneiHs.733638.

Genome annotation databases

EnsembliENST00000343118; ENSP00000343318; ENSG00000183778.
ENST00000380618; ENSP00000369992; ENSG00000183778.
ENST00000380620; ENSP00000369994; ENSG00000183778.
ENST00000398714; ENSP00000381699; ENSG00000183778.
GeneIDi10317.
KEGGihsa:10317.
UCSCiuc002yyb.1. human.

Polymorphism databases

DMDMi13123995.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

GGDB

GlycoGene database

Functional Glycomics Gateway - GTase

Beta-1,3-galactosyltransferase 5

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB020337 mRNA. Translation: BAA77664.1 .
AF145784 Genomic DNA. Translation: AAF07880.1 .
AJ006078 Genomic DNA. Translation: CAB91547.1 .
AY372061 mRNA. Translation: AAR08910.1 .
AK292951 mRNA. Translation: BAF85640.1 .
AL163280 Genomic DNA. Translation: CAB90446.1 .
CH471079 Genomic DNA. Translation: EAX09629.1 .
CH471079 Genomic DNA. Translation: EAX09630.1 .
CH471079 Genomic DNA. Translation: EAX09631.1 .
CH471079 Genomic DNA. Translation: EAX09632.1 .
BC104862 mRNA. Translation: AAI04863.1 .
BC104864 mRNA. Translation: AAI04865.1 .
AB041413 Genomic DNA. Translation: BAA94498.1 .
AB041416 Genomic DNA. Translation: BAA94501.1 .
CCDSi CCDS13667.1.
RefSeqi NP_001265579.1. NM_001278650.1.
NP_006048.1. NM_006057.2.
NP_149360.1. NM_033170.2.
NP_149361.1. NM_033171.2.
NP_149362.2. NM_033172.2.
XP_005260969.1. XM_005260912.1.
UniGenei Hs.733638.

3D structure databases

ProteinModelPortali Q9Y2C3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000343318.

Chemistry

ChEMBLi CHEMBL2321635.

Protein family/group databases

CAZyi GT31. Glycosyltransferase Family 31.

Polymorphism databases

DMDMi 13123995.

Proteomic databases

PaxDbi Q9Y2C3.
PeptideAtlasi Q9Y2C3.
PRIDEi Q9Y2C3.

Protocols and materials databases

DNASUi 10317.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000343118 ; ENSP00000343318 ; ENSG00000183778 .
ENST00000380618 ; ENSP00000369992 ; ENSG00000183778 .
ENST00000380620 ; ENSP00000369994 ; ENSG00000183778 .
ENST00000398714 ; ENSP00000381699 ; ENSG00000183778 .
GeneIDi 10317.
KEGGi hsa:10317.
UCSCi uc002yyb.1. human.

Organism-specific databases

CTDi 10317.
GeneCardsi GC21P040928.
HGNCi HGNC:920. B3GALT5.
HPAi HPA054092.
HPA054684.
MIMi 604066. gene.
neXtProti NX_Q9Y2C3.
PharmGKBi PA25213.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG293774.
HOVERGENi HBG094868.
InParanoidi Q9Y2C3.
KOi K03877.
OMAi RFCPQAA.
OrthoDBi EOG7M3J0F.
PhylomeDBi Q9Y2C3.
TreeFami TF318639.

Enzyme and pathway databases

UniPathwayi UPA00378 .

Miscellaneous databases

GeneWikii B3GALT5.
GenomeRNAii 10317.
NextBioi 39103.
PROi Q9Y2C3.
SOURCEi Search...

Gene expression databases

Bgeei Q9Y2C3.
CleanExi HS_B3GALT5.
Genevestigatori Q9Y2C3.

Family and domain databases

InterProi IPR002659. Glyco_trans_31.
[Graphical view ]
PANTHERi PTHR11214. PTHR11214. 1 hit.
Pfami PF01762. Galactosyl_T. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, expression, and characterization of a novel UDP-galactose:beta-N-acetylglucosamine beta1,3-galactosyltransferase (beta3Gal-T5) responsible for synthesis of type 1 chain in colorectal and pancreatic epithelia and tumor cells derived therefrom."
    Isshiki S., Togayachi A., Kudo T., Nishihara S., Watanabe M., Kubota T., Kitajima M., Shiraishi N., Sasaki K., Andoh T., Narimatsu H.
    J. Biol. Chem. 274:12499-12507(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Colon adenocarcinoma.
  2. "Molecular cloning of a human UDP-galactose:GlcNAcbeta1,3GalNAc beta1, 3 galactosyltransferase gene encoding an O-linked core3-elongation enzyme."
    Zhou D., Berger E.G., Hennet T.
    Eur. J. Biochem. 263:571-576(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Cloning and expression of two beta-1,3-galactosyltransferases: beta3gal-T5 and beta3gal-T6."
    Amado M., Carneiro F., Clausen H.
    Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-85.
  4. "An endogenous retroviral long terminal repeat is the dominant promoter for human beta1,3-galactosyltransferase 5 in the colon."
    Dunn C.A., Medstrand P., Mager D.L.
    Proc. Natl. Acad. Sci. U.S.A. 100:12841-12846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-85.
    Tissue: Trachea.
  6. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT THR-85.
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-85.
    Tissue: Colon.
  9. Liu Y., Saitou N.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-298, VARIANT THR-85.
  10. "Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions."
    Amado M., Almeida R., Schwientek T., Clausen H.
    Biochim. Biophys. Acta 1473:35-53(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiB3GT5_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2C3
Secondary accession number(s): A8KA86
, D3DSI3, Q2M3L5, Q53Z19, Q9NY96, Q9P1X6, Q9P1X7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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