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Protein

Uronyl 2-sulfotransferase

Gene

UST

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Sulfotransferase that catalyzes the transfer of sulfate to the position 2 of uronyl residues. Has mainly activity toward iduronyl residues in dermatan sulfate, and weaker activity toward glucuronyl residues of chondroitin sulfate. Has no activity toward desulfated N-resulfated heparin.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000111962-MONOMER.
ZFISH:ENSG00000111962-MONOMER.
ReactomeiR-HSA-2022923. Dermatan sulfate biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Uronyl 2-sulfotransferase (EC:2.8.2.-)
Gene namesi
Name:UST
Synonyms:DS2ST
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:17223. UST.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 49CytoplasmicSequence analysisAdd BLAST49
Transmembranei50 – 70Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini71 – 406LumenalSequence analysisAdd BLAST336

GO - Cellular componenti

  • Golgi membrane Source: Reactome
  • integral component of membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10090.
OpenTargetsiENSG00000111962.
PharmGKBiPA38213.

Polymorphism and mutation databases

BioMutaiUST.
DMDMi68052988.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002076811 – 406Uronyl 2-sulfotransferaseAdd BLAST406

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi84N-linked (GlcNAc...)Sequence analysis1
Glycosylationi140N-linked (GlcNAc...)Sequence analysis1
Glycosylationi155N-linked (GlcNAc...)Sequence analysis1
Glycosylationi173N-linked (GlcNAc...)Sequence analysis1
Glycosylationi319N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9Y2C2.
MaxQBiQ9Y2C2.
PaxDbiQ9Y2C2.
PeptideAtlasiQ9Y2C2.
PRIDEiQ9Y2C2.

PTM databases

iPTMnetiQ9Y2C2.
PhosphoSitePlusiQ9Y2C2.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000111962.
CleanExiHS_UST.
GenevisibleiQ9Y2C2. HS.

Organism-specific databases

HPAiHPA032022.

Interactioni

Protein-protein interaction databases

BioGridi115398. 20 interactors.
IntActiQ9Y2C2. 2 interactors.
MINTiMINT-7970884.
STRINGi9606.ENSP00000356433.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2C2.
SMRiQ9Y2C2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sulfotransferase 3 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3922. Eukaryota.
ENOG410XTA1. LUCA.
GeneTreeiENSGT00530000063408.
HOGENOMiHOG000059649.
HOVERGENiHBG086208.
InParanoidiQ9Y2C2.
KOiK03193.
OMAiRPHFFIP.
OrthoDBiEOG091G0VTJ.
PhylomeDBiQ9Y2C2.
TreeFamiTF315238.

Family and domain databases

InterProiIPR007734. Heparan_SO4_2-O-STrfase.
IPR027417. P-loop_NTPase.
IPR005331. Sulfotransferase.
[Graphical view]
PANTHERiPTHR12129. PTHR12129. 1 hit.
PfamiPF03567. Sulfotransfer_2. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Y2C2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKKQQHPGG GADPWPHGAP MGGAPPGLGS WKRRVPLLPF LRFSLRDYGF
60 70 80 90 100
CMATLLVFCL GSLLYQLSGG PPRFLLDLRQ YLGNSTYLDD HGPPPSKVLP
110 120 130 140 150
FPSQVVYNRV GKCGSRTVVL LLRILSEKHG FNLVTSDIHN KTRLTKNEQM
160 170 180 190 200
ELIKNISTAE QPYLFTRHVH FLNFSRFGGD QPVYINIIRD PVNRFLSNYF
210 220 230 240 250
FRRFGDWRGE QNHMIRTPSM RQEERYLDIN ECILENYPEC SNPRLFYIIP
260 270 280 290 300
YFCGQHPRCR EPGEWALERA KLNVNENFLL VGILEELEDV LLLLERFLPH
310 320 330 340 350
YFKGVLSIYK DPEHRKLGNM TVTVKKTVPS PEAVQILYQR MRYEYEFYHY
360 370 380 390 400
VKEQFHLLKR KFGLKSHVSK PPLRPHFFIP TPLETEEPID DEEQDDEKWL

EDIYKR
Length:406
Mass (Da):47,673
Last modified:November 1, 1999 - v1
Checksum:i7F201FEBBFA3B2EA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05981921M → L.Corresponds to variant rs9498146dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020316 mRNA. Translation: BAA77510.1.
AK315320 mRNA. Translation: BAG37723.1.
AL357992
, AL359252, AL590485, AL807246 Genomic DNA. Translation: CAH70738.1.
AL359252
, AL357992, AL590485, AL807246 Genomic DNA. Translation: CAH70147.1.
AL590485
, AL357992, AL359252, AL807246 Genomic DNA. Translation: CAI17058.1.
AL807246
, AL357992, AL359252, AL590485 Genomic DNA. Translation: CAH74028.1.
CH471051 Genomic DNA. Translation: EAW47812.1.
BC093668 mRNA. Translation: AAH93668.1.
BC093694 mRNA. Translation: AAH93694.1.
CCDSiCCDS5213.1.
RefSeqiNP_005706.1. NM_005715.2.
UniGeneiHs.657370.

Genome annotation databases

EnsembliENST00000367463; ENSP00000356433; ENSG00000111962.
GeneIDi10090.
KEGGihsa:10090.
UCSCiuc003qmg.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020316 mRNA. Translation: BAA77510.1.
AK315320 mRNA. Translation: BAG37723.1.
AL357992
, AL359252, AL590485, AL807246 Genomic DNA. Translation: CAH70738.1.
AL359252
, AL357992, AL590485, AL807246 Genomic DNA. Translation: CAH70147.1.
AL590485
, AL357992, AL359252, AL807246 Genomic DNA. Translation: CAI17058.1.
AL807246
, AL357992, AL359252, AL590485 Genomic DNA. Translation: CAH74028.1.
CH471051 Genomic DNA. Translation: EAW47812.1.
BC093668 mRNA. Translation: AAH93668.1.
BC093694 mRNA. Translation: AAH93694.1.
CCDSiCCDS5213.1.
RefSeqiNP_005706.1. NM_005715.2.
UniGeneiHs.657370.

3D structure databases

ProteinModelPortaliQ9Y2C2.
SMRiQ9Y2C2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115398. 20 interactors.
IntActiQ9Y2C2. 2 interactors.
MINTiMINT-7970884.
STRINGi9606.ENSP00000356433.

PTM databases

iPTMnetiQ9Y2C2.
PhosphoSitePlusiQ9Y2C2.

Polymorphism and mutation databases

BioMutaiUST.
DMDMi68052988.

Proteomic databases

EPDiQ9Y2C2.
MaxQBiQ9Y2C2.
PaxDbiQ9Y2C2.
PeptideAtlasiQ9Y2C2.
PRIDEiQ9Y2C2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367463; ENSP00000356433; ENSG00000111962.
GeneIDi10090.
KEGGihsa:10090.
UCSCiuc003qmg.4. human.

Organism-specific databases

CTDi10090.
DisGeNETi10090.
GeneCardsiUST.
HGNCiHGNC:17223. UST.
HPAiHPA032022.
MIMi610752. gene.
neXtProtiNX_Q9Y2C2.
OpenTargetsiENSG00000111962.
PharmGKBiPA38213.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3922. Eukaryota.
ENOG410XTA1. LUCA.
GeneTreeiENSGT00530000063408.
HOGENOMiHOG000059649.
HOVERGENiHBG086208.
InParanoidiQ9Y2C2.
KOiK03193.
OMAiRPHFFIP.
OrthoDBiEOG091G0VTJ.
PhylomeDBiQ9Y2C2.
TreeFamiTF315238.

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000111962-MONOMER.
ZFISH:ENSG00000111962-MONOMER.
ReactomeiR-HSA-2022923. Dermatan sulfate biosynthesis.

Miscellaneous databases

ChiTaRSiUST. human.
GenomeRNAii10090.
PROiQ9Y2C2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000111962.
CleanExiHS_UST.
GenevisibleiQ9Y2C2. HS.

Family and domain databases

InterProiIPR007734. Heparan_SO4_2-O-STrfase.
IPR027417. P-loop_NTPase.
IPR005331. Sulfotransferase.
[Graphical view]
PANTHERiPTHR12129. PTHR12129. 1 hit.
PfamiPF03567. Sulfotransfer_2. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiUST_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2C2
Secondary accession number(s): B2RCX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.