Q9Y2B9 (IPKG_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
cAMP-dependent protein kinase inhibitor gamma
Short name=PKI-gamma

Gene names

Name:

PKIG

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	76 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains By similarity.
Tissue specificity	Ubiquitous.
Sequence similarities	Belongs to the PKI family.

Ontologies

Keywords
Molecular function	Protein kinase inhibitor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of protein import into nucleus Inferred from electronic annotation. Source: Compara negative regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara signal transduction Inferred from electronic annotation. Source: Compara
Molecular_function	cAMP-dependent protein kinase inhibitor activity Traceable author statement Ref.2. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
KPTN	Q9Y664	1	EBI-1052231,EBI-1048252
PRKACA	P17612	1	EBI-1052231,EBI-476586
RAB25	P57735	1	EBI-1052231,EBI-1050500
RPA3	P35244	1	EBI-1052231,EBI-621428

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 76	76	cAMP-dependent protein kinase inhibitor gamma		PRO_0000154542

Sequences

	Sequence		Length	Mass (Da)
	Q9Y2B9 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: F01B4C73ED2CC6EE	FASTA	76	7,910
	10 20 30 40 50 60 MMEVESSYSD FISCDRTGRR NAVPDIQGDS EAVSVRKLAG DMGELALEGA EGQVEGSAPD 70 KEAGNQPQSS DGTTSS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Protein kinase inhibitor gamma mRNA, complete cds." Saito T., Miyajima N. Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Characterization of PKI-gamma, a novel isoform of the protein kinase inhibitor of cAMP-dependent protein kinase." Collins S.P., Uhler M.D. J. Biol. Chem. 272:18169-18178(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Parathyroid.
[3]	"Cloning and mapping of human PKIB and PKIG, and comparison of tissue expression patterns of three members of the protein kinase inhibitor family, including PKIA." Zheng L., Yu L., Tu Q., Zhang M., He H., Chen W., Gao J., Yu J., Wu Q., Zhao S. Biochem. J. 349:403-407(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB019517 mRNA. Translation: BAA77336.1. AF182032 mRNA. Translation: AAD55445.1. Z97053 Genomic DNA. Translation: CAC18874.1.
IPI	IPI00032010.
RefSeq	NP_008997.1. NM_007066.3. NP_861520.1. NM_181804.1. NP_861521.1. NM_181805.1.
UniGene	Hs.472831.
3D structure databases
ProteinModelPortal	Q9Y2B9.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000338067.
PTM databases
PhosphoSite	Q9Y2B9.
Polymorphism databases
DMDM	8134508.
Proteomic databases
PaxDb	Q9Y2B9.
PRIDE	Q9Y2B9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000349959; ENSP00000338067; ENSG00000168734. ENST00000372886; ENSP00000361977; ENSG00000168734. ENST00000372889; ENSP00000361980; ENSG00000168734. ENST00000372891; ENSP00000361981; ENSG00000168734. ENST00000372892; ENSP00000361983; ENSG00000168734. ENST00000372894; ENSP00000361985; ENSG00000168734.
GeneID	11142.
KEGG	hsa:11142.
UCSC	uc002xmg.3. human.
Organism-specific databases
CTD	11142.
GeneCards	GC20P043160.
HGNC	HGNC:9019. PKIG.
HPA	HPA042703.
MIM	604932. gene.
neXtProt	NX_Q9Y2B9.
PharmGKB	PA33351.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG39013.
HOGENOM	HOG000059641.
HOVERGEN	HBG104492.
InParanoid	Q9Y2B9.
OrthoDB	EOG4STS69.
PhylomeDB	Q9Y2B9.
Gene expression databases
ArrayExpress	Q9Y2B9.
Bgee	Q9Y2B9.
CleanEx	HS_PKIG.
Genevestigator	Q9Y2B9.
GermOnline	ENSG00000168734. Homo sapiens.
Family and domain databases
InterPro	IPR004171. cAMP_dep_PKI. [Graphical view]
Pfam	PF02827. PKI. 1 hit. [Graphical view]
PIRSF	PIRSF001667. PKI. 1 hit.
ProDom	PD010366. cAMP_dep_PKI. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...
Other
GenomeRNAi	11142.
NextBio	42352.
SOURCE	Search...

Entry information

Entry name

IPKG_HUMAN

Accession

Primary (citable) accession number: Q9Y2B9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1999
Last modified:	April 3, 2013
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.