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Q9Y2B9

- IPKG_HUMAN

UniProt

Q9Y2B9 - IPKG_HUMAN

Protein

cAMP-dependent protein kinase inhibitor gamma

Gene

PKIG

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.By similarity

    GO - Molecular functioni

    1. cAMP-dependent protein kinase inhibitor activity Source: ProtInc

    GO - Biological processi

    1. negative regulation of protein import into nucleus Source: Ensembl
    2. negative regulation of protein serine/threonine kinase activity Source: GOC
    3. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    4. signal transduction Source: Ensembl

    Keywords - Molecular functioni

    Protein kinase inhibitor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    cAMP-dependent protein kinase inhibitor gamma
    Short name:
    PKI-gamma
    Gene namesi
    Name:PKIG
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:9019. PKIG.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33351.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 7676cAMP-dependent protein kinase inhibitor gammaPRO_0000154542Add
    BLAST

    Proteomic databases

    MaxQBiQ9Y2B9.
    PaxDbiQ9Y2B9.
    PRIDEiQ9Y2B9.

    PTM databases

    PhosphoSiteiQ9Y2B9.

    Expressioni

    Tissue specificityi

    Ubiquitous.

    Gene expression databases

    ArrayExpressiQ9Y2B9.
    BgeeiQ9Y2B9.
    CleanExiHS_PKIG.
    GenevestigatoriQ9Y2B9.

    Organism-specific databases

    HPAiHPA042703.

    Interactioni

    Protein-protein interaction databases

    BioGridi116314. 4 interactions.
    STRINGi9606.ENSP00000338067.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y2B9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PKI family.Curated

    Phylogenomic databases

    eggNOGiNOG39013.
    HOGENOMiHOG000059641.
    HOVERGENiHBG104492.
    InParanoidiQ9Y2B9.
    OMAiNITINME.
    OrthoDBiEOG7JHM8S.
    PhylomeDBiQ9Y2B9.
    TreeFamiTF330809.

    Family and domain databases

    InterProiIPR004171. cAMP_dep_PKI.
    [Graphical view]
    PfamiPF02827. PKI. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001667. PKI. 1 hit.
    ProDomiPD010366. cAMP_dep_PKI. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    Q9Y2B9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMEVESSYSD FISCDRTGRR NAVPDIQGDS EAVSVRKLAG DMGELALEGA   50
    EGQVEGSAPD KEAGNQPQSS DGTTSS 76
    Length:76
    Mass (Da):7,910
    Last modified:November 1, 1999 - v1
    Checksum:iF01B4C73ED2CC6EE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB019517 mRNA. Translation: BAA77336.1.
    AF182032 mRNA. Translation: AAD55445.1.
    Z97053 Genomic DNA. Translation: CAC18874.1.
    CCDSiCCDS13334.1.
    RefSeqiNP_001268373.1. NM_001281444.1.
    NP_001268374.1. NM_001281445.1.
    NP_008997.1. NM_007066.4.
    NP_861520.1. NM_181804.2.
    NP_861521.1. NM_181805.2.
    UniGeneiHs.472831.

    Genome annotation databases

    EnsembliENST00000349959; ENSP00000338067; ENSG00000168734.
    ENST00000372886; ENSP00000361977; ENSG00000168734.
    ENST00000372889; ENSP00000361980; ENSG00000168734.
    ENST00000372891; ENSP00000361981; ENSG00000168734.
    ENST00000372892; ENSP00000361983; ENSG00000168734.
    ENST00000372894; ENSP00000361985; ENSG00000168734.
    GeneIDi11142.
    KEGGihsa:11142.
    UCSCiuc002xmg.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB019517 mRNA. Translation: BAA77336.1 .
    AF182032 mRNA. Translation: AAD55445.1 .
    Z97053 Genomic DNA. Translation: CAC18874.1 .
    CCDSi CCDS13334.1.
    RefSeqi NP_001268373.1. NM_001281444.1.
    NP_001268374.1. NM_001281445.1.
    NP_008997.1. NM_007066.4.
    NP_861520.1. NM_181804.2.
    NP_861521.1. NM_181805.2.
    UniGenei Hs.472831.

    3D structure databases

    ProteinModelPortali Q9Y2B9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116314. 4 interactions.
    STRINGi 9606.ENSP00000338067.

    PTM databases

    PhosphoSitei Q9Y2B9.

    Proteomic databases

    MaxQBi Q9Y2B9.
    PaxDbi Q9Y2B9.
    PRIDEi Q9Y2B9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000349959 ; ENSP00000338067 ; ENSG00000168734 .
    ENST00000372886 ; ENSP00000361977 ; ENSG00000168734 .
    ENST00000372889 ; ENSP00000361980 ; ENSG00000168734 .
    ENST00000372891 ; ENSP00000361981 ; ENSG00000168734 .
    ENST00000372892 ; ENSP00000361983 ; ENSG00000168734 .
    ENST00000372894 ; ENSP00000361985 ; ENSG00000168734 .
    GeneIDi 11142.
    KEGGi hsa:11142.
    UCSCi uc002xmg.3. human.

    Organism-specific databases

    CTDi 11142.
    GeneCardsi GC20P043160.
    HGNCi HGNC:9019. PKIG.
    HPAi HPA042703.
    MIMi 604932. gene.
    neXtProti NX_Q9Y2B9.
    PharmGKBi PA33351.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG39013.
    HOGENOMi HOG000059641.
    HOVERGENi HBG104492.
    InParanoidi Q9Y2B9.
    OMAi NITINME.
    OrthoDBi EOG7JHM8S.
    PhylomeDBi Q9Y2B9.
    TreeFami TF330809.

    Miscellaneous databases

    GeneWikii PKIG.
    GenomeRNAii 11142.
    NextBioi 42352.
    PROi Q9Y2B9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y2B9.
    Bgeei Q9Y2B9.
    CleanExi HS_PKIG.
    Genevestigatori Q9Y2B9.

    Family and domain databases

    InterProi IPR004171. cAMP_dep_PKI.
    [Graphical view ]
    Pfami PF02827. PKI. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001667. PKI. 1 hit.
    ProDomi PD010366. cAMP_dep_PKI. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "Protein kinase inhibitor gamma mRNA, complete cds."
      Saito T., Miyajima N.
      Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Characterization of PKI-gamma, a novel isoform of the protein kinase inhibitor of cAMP-dependent protein kinase."
      Collins S.P., Uhler M.D.
      J. Biol. Chem. 272:18169-18178(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Parathyroid.
    3. "Cloning and mapping of human PKIB and PKIG, and comparison of tissue expression patterns of three members of the protein kinase inhibitor family, including PKIA."
      Zheng L., Yu L., Tu Q., Zhang M., He H., Chen W., Gao J., Yu J., Wu Q., Zhao S.
      Biochem. J. 349:403-407(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiIPKG_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y2B9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3