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Q9Y2B9

- IPKG_HUMAN

UniProt

Q9Y2B9 - IPKG_HUMAN

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Protein

cAMP-dependent protein kinase inhibitor gamma

Gene

PKIG

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.By similarity

GO - Molecular functioni

  1. cAMP-dependent protein kinase inhibitor activity Source: ProtInc

GO - Biological processi

  1. negative regulation of protein import into nucleus Source: Ensembl
  2. negative regulation of protein serine/threonine kinase activity Source: GOC
  3. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  4. signal transduction Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Protein kinase inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
cAMP-dependent protein kinase inhibitor gamma
Short name:
PKI-gamma
Gene namesi
Name:PKIG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:9019. PKIG.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33351.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7676cAMP-dependent protein kinase inhibitor gammaPRO_0000154542Add
BLAST

Proteomic databases

MaxQBiQ9Y2B9.
PaxDbiQ9Y2B9.
PRIDEiQ9Y2B9.

PTM databases

PhosphoSiteiQ9Y2B9.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiQ9Y2B9.
CleanExiHS_PKIG.
ExpressionAtlasiQ9Y2B9. baseline and differential.
GenevestigatoriQ9Y2B9.

Organism-specific databases

HPAiHPA042703.

Interactioni

Protein-protein interaction databases

BioGridi116314. 4 interactions.
STRINGi9606.ENSP00000338067.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2B9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PKI family.Curated

Phylogenomic databases

eggNOGiNOG39013.
GeneTreeiENSGT00390000002707.
HOGENOMiHOG000059641.
HOVERGENiHBG104492.
InParanoidiQ9Y2B9.
OMAiNITINME.
OrthoDBiEOG7JHM8S.
PhylomeDBiQ9Y2B9.
TreeFamiTF330809.

Family and domain databases

InterProiIPR004171. cAMP_dep_PKI.
[Graphical view]
PfamiPF02827. PKI. 1 hit.
[Graphical view]
PIRSFiPIRSF001667. PKI. 1 hit.
ProDomiPD010366. cAMP_dep_PKI. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q9Y2B9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMEVESSYSD FISCDRTGRR NAVPDIQGDS EAVSVRKLAG DMGELALEGA
60 70
EGQVEGSAPD KEAGNQPQSS DGTTSS
Length:76
Mass (Da):7,910
Last modified:November 1, 1999 - v1
Checksum:iF01B4C73ED2CC6EE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB019517 mRNA. Translation: BAA77336.1.
AF182032 mRNA. Translation: AAD55445.1.
Z97053 Genomic DNA. Translation: CAC18874.1.
CCDSiCCDS13334.1.
RefSeqiNP_001268373.1. NM_001281444.1.
NP_001268374.1. NM_001281445.1.
NP_008997.1. NM_007066.4.
NP_861520.1. NM_181804.2.
NP_861521.1. NM_181805.2.
UniGeneiHs.472831.

Genome annotation databases

EnsembliENST00000349959; ENSP00000338067; ENSG00000168734.
ENST00000372886; ENSP00000361977; ENSG00000168734.
ENST00000372889; ENSP00000361980; ENSG00000168734.
ENST00000372891; ENSP00000361981; ENSG00000168734.
ENST00000372892; ENSP00000361983; ENSG00000168734.
ENST00000372894; ENSP00000361985; ENSG00000168734.
GeneIDi11142.
KEGGihsa:11142.
UCSCiuc002xmg.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB019517 mRNA. Translation: BAA77336.1 .
AF182032 mRNA. Translation: AAD55445.1 .
Z97053 Genomic DNA. Translation: CAC18874.1 .
CCDSi CCDS13334.1.
RefSeqi NP_001268373.1. NM_001281444.1.
NP_001268374.1. NM_001281445.1.
NP_008997.1. NM_007066.4.
NP_861520.1. NM_181804.2.
NP_861521.1. NM_181805.2.
UniGenei Hs.472831.

3D structure databases

ProteinModelPortali Q9Y2B9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116314. 4 interactions.
STRINGi 9606.ENSP00000338067.

PTM databases

PhosphoSitei Q9Y2B9.

Proteomic databases

MaxQBi Q9Y2B9.
PaxDbi Q9Y2B9.
PRIDEi Q9Y2B9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000349959 ; ENSP00000338067 ; ENSG00000168734 .
ENST00000372886 ; ENSP00000361977 ; ENSG00000168734 .
ENST00000372889 ; ENSP00000361980 ; ENSG00000168734 .
ENST00000372891 ; ENSP00000361981 ; ENSG00000168734 .
ENST00000372892 ; ENSP00000361983 ; ENSG00000168734 .
ENST00000372894 ; ENSP00000361985 ; ENSG00000168734 .
GeneIDi 11142.
KEGGi hsa:11142.
UCSCi uc002xmg.3. human.

Organism-specific databases

CTDi 11142.
GeneCardsi GC20P043160.
HGNCi HGNC:9019. PKIG.
HPAi HPA042703.
MIMi 604932. gene.
neXtProti NX_Q9Y2B9.
PharmGKBi PA33351.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG39013.
GeneTreei ENSGT00390000002707.
HOGENOMi HOG000059641.
HOVERGENi HBG104492.
InParanoidi Q9Y2B9.
OMAi NITINME.
OrthoDBi EOG7JHM8S.
PhylomeDBi Q9Y2B9.
TreeFami TF330809.

Miscellaneous databases

GeneWikii PKIG.
GenomeRNAii 11142.
NextBioi 42352.
PROi Q9Y2B9.
SOURCEi Search...

Gene expression databases

Bgeei Q9Y2B9.
CleanExi HS_PKIG.
ExpressionAtlasi Q9Y2B9. baseline and differential.
Genevestigatori Q9Y2B9.

Family and domain databases

InterProi IPR004171. cAMP_dep_PKI.
[Graphical view ]
Pfami PF02827. PKI. 1 hit.
[Graphical view ]
PIRSFi PIRSF001667. PKI. 1 hit.
ProDomi PD010366. cAMP_dep_PKI. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Protein kinase inhibitor gamma mRNA, complete cds."
    Saito T., Miyajima N.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Characterization of PKI-gamma, a novel isoform of the protein kinase inhibitor of cAMP-dependent protein kinase."
    Collins S.P., Uhler M.D.
    J. Biol. Chem. 272:18169-18178(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Parathyroid.
  3. "Cloning and mapping of human PKIB and PKIG, and comparison of tissue expression patterns of three members of the protein kinase inhibitor family, including PKIA."
    Zheng L., Yu L., Tu Q., Zhang M., He H., Chen W., Gao J., Yu J., Wu Q., Zhao S.
    Biochem. J. 349:403-407(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiIPKG_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2B9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: October 29, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3