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Q9Y2B9 (IPKG_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
cAMP-dependent protein kinase inhibitor gamma

Short name=PKI-gamma
Gene names
Name:PKIG
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length76 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains By similarity.

Tissue specificity

Ubiquitous.

Sequence similarities

Belongs to the PKI family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 7676cAMP-dependent protein kinase inhibitor gamma
PRO_0000154542

Sequences

Sequence LengthMass (Da)Tools
Q9Y2B9 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: F01B4C73ED2CC6EE

FASTA767,910
        10         20         30         40         50         60 
MMEVESSYSD FISCDRTGRR NAVPDIQGDS EAVSVRKLAG DMGELALEGA EGQVEGSAPD 

        70 
KEAGNQPQSS DGTTSS 

« Hide

References

« Hide 'large scale' references
[1]"Protein kinase inhibitor gamma mRNA, complete cds."
Saito T., Miyajima N.
Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Characterization of PKI-gamma, a novel isoform of the protein kinase inhibitor of cAMP-dependent protein kinase."
Collins S.P., Uhler M.D.
J. Biol. Chem. 272:18169-18178(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Parathyroid.
[3]"Cloning and mapping of human PKIB and PKIG, and comparison of tissue expression patterns of three members of the protein kinase inhibitor family, including PKIA."
Zheng L., Yu L., Tu Q., Zhang M., He H., Chen W., Gao J., Yu J., Wu Q., Zhao S.
Biochem. J. 349:403-407(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB019517 mRNA. Translation: BAA77336.1.
AF182032 mRNA. Translation: AAD55445.1.
Z97053 Genomic DNA. Translation: CAC18874.1.
RefSeqNP_001268373.1. NM_001281444.1.
NP_001268374.1. NM_001281445.1.
NP_008997.1. NM_007066.4.
NP_861520.1. NM_181804.2.
NP_861521.1. NM_181805.2.
UniGeneHs.472831.

3D structure databases

ProteinModelPortalQ9Y2B9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116314. 4 interactions.
STRING9606.ENSP00000338067.

PTM databases

PhosphoSiteQ9Y2B9.

Polymorphism databases

DMDM8134508.

Proteomic databases

PaxDbQ9Y2B9.
PRIDEQ9Y2B9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000349959; ENSP00000338067; ENSG00000168734.
ENST00000372886; ENSP00000361977; ENSG00000168734.
ENST00000372889; ENSP00000361980; ENSG00000168734.
ENST00000372891; ENSP00000361981; ENSG00000168734.
ENST00000372892; ENSP00000361983; ENSG00000168734.
ENST00000372894; ENSP00000361985; ENSG00000168734.
GeneID11142.
KEGGhsa:11142.
UCSCuc002xmg.3. human.

Organism-specific databases

CTD11142.
GeneCardsGC20P043160.
HGNCHGNC:9019. PKIG.
HPAHPA042703.
MIM604932. gene.
neXtProtNX_Q9Y2B9.
PharmGKBPA33351.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG39013.
HOGENOMHOG000059641.
HOVERGENHBG104492.
InParanoidQ9Y2B9.
OMAEASNQPE.
OrthoDBEOG7JHM8S.
PhylomeDBQ9Y2B9.
TreeFamTF330809.

Gene expression databases

ArrayExpressQ9Y2B9.
BgeeQ9Y2B9.
CleanExHS_PKIG.
GenevestigatorQ9Y2B9.

Family and domain databases

InterProIPR004171. cAMP_dep_PKI.
[Graphical view]
PfamPF02827. PKI. 1 hit.
[Graphical view]
PIRSFPIRSF001667. PKI. 1 hit.
ProDomPD010366. cAMP_dep_PKI. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Other

GeneWikiPKIG.
GenomeRNAi11142.
NextBio42352.
PROQ9Y2B9.
SOURCESearch...

Entry information

Entry nameIPKG_HUMAN
AccessionPrimary (citable) accession number: Q9Y2B9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: February 19, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM