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Protein

cAMP-dependent protein kinase inhibitor gamma

Gene

PKIG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.By similarity

GO - Molecular functioni

  1. cAMP-dependent protein kinase inhibitor activity Source: ProtInc

GO - Biological processi

  1. negative regulation of cAMP-dependent protein kinase activity Source: GO_Central
  2. negative regulation of protein import into nucleus Source: Ensembl
  3. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  4. signal transduction Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Protein kinase inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
cAMP-dependent protein kinase inhibitor gamma
Short name:
PKI-gamma
Gene namesi
Name:PKIG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:9019. PKIG.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: GO_Central
  2. nucleus Source: GO_Central
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33351.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7676cAMP-dependent protein kinase inhibitor gammaPRO_0000154542Add
BLAST

Proteomic databases

MaxQBiQ9Y2B9.
PaxDbiQ9Y2B9.
PRIDEiQ9Y2B9.

PTM databases

PhosphoSiteiQ9Y2B9.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiQ9Y2B9.
CleanExiHS_PKIG.
ExpressionAtlasiQ9Y2B9. baseline and differential.
GenevestigatoriQ9Y2B9.

Organism-specific databases

HPAiHPA042703.

Interactioni

Protein-protein interaction databases

BioGridi116314. 5 interactions.
STRINGi9606.ENSP00000338067.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2B9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PKI family.Curated

Phylogenomic databases

eggNOGiNOG39013.
GeneTreeiENSGT00390000002707.
HOGENOMiHOG000059641.
HOVERGENiHBG104492.
InParanoidiQ9Y2B9.
OMAiDATGMME.
OrthoDBiEOG7JHM8S.
PhylomeDBiQ9Y2B9.
TreeFamiTF330809.

Family and domain databases

InterProiIPR004171. cAMP_dep_PKI.
[Graphical view]
PfamiPF02827. PKI. 1 hit.
[Graphical view]
PIRSFiPIRSF001667. PKI. 1 hit.
ProDomiPD010366. cAMP_dep_PKI. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q9Y2B9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMEVESSYSD FISCDRTGRR NAVPDIQGDS EAVSVRKLAG DMGELALEGA
60 70
EGQVEGSAPD KEAGNQPQSS DGTTSS
Length:76
Mass (Da):7,910
Last modified:October 31, 1999 - v1
Checksum:iF01B4C73ED2CC6EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019517 mRNA. Translation: BAA77336.1.
AF182032 mRNA. Translation: AAD55445.1.
Z97053 Genomic DNA. Translation: CAC18874.1.
CCDSiCCDS13334.1.
RefSeqiNP_001268373.1. NM_001281444.1.
NP_001268374.1. NM_001281445.1.
NP_008997.1. NM_007066.4.
NP_861520.1. NM_181804.2.
NP_861521.1. NM_181805.2.
UniGeneiHs.472831.

Genome annotation databases

EnsembliENST00000349959; ENSP00000338067; ENSG00000168734.
ENST00000372886; ENSP00000361977; ENSG00000168734.
ENST00000372889; ENSP00000361980; ENSG00000168734.
ENST00000372891; ENSP00000361981; ENSG00000168734.
ENST00000372892; ENSP00000361983; ENSG00000168734.
ENST00000372894; ENSP00000361985; ENSG00000168734.
GeneIDi11142.
KEGGihsa:11142.
UCSCiuc002xmg.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019517 mRNA. Translation: BAA77336.1.
AF182032 mRNA. Translation: AAD55445.1.
Z97053 Genomic DNA. Translation: CAC18874.1.
CCDSiCCDS13334.1.
RefSeqiNP_001268373.1. NM_001281444.1.
NP_001268374.1. NM_001281445.1.
NP_008997.1. NM_007066.4.
NP_861520.1. NM_181804.2.
NP_861521.1. NM_181805.2.
UniGeneiHs.472831.

3D structure databases

ProteinModelPortaliQ9Y2B9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116314. 5 interactions.
STRINGi9606.ENSP00000338067.

PTM databases

PhosphoSiteiQ9Y2B9.

Proteomic databases

MaxQBiQ9Y2B9.
PaxDbiQ9Y2B9.
PRIDEiQ9Y2B9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000349959; ENSP00000338067; ENSG00000168734.
ENST00000372886; ENSP00000361977; ENSG00000168734.
ENST00000372889; ENSP00000361980; ENSG00000168734.
ENST00000372891; ENSP00000361981; ENSG00000168734.
ENST00000372892; ENSP00000361983; ENSG00000168734.
ENST00000372894; ENSP00000361985; ENSG00000168734.
GeneIDi11142.
KEGGihsa:11142.
UCSCiuc002xmg.3. human.

Organism-specific databases

CTDi11142.
GeneCardsiGC20P043160.
HGNCiHGNC:9019. PKIG.
HPAiHPA042703.
MIMi604932. gene.
neXtProtiNX_Q9Y2B9.
PharmGKBiPA33351.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG39013.
GeneTreeiENSGT00390000002707.
HOGENOMiHOG000059641.
HOVERGENiHBG104492.
InParanoidiQ9Y2B9.
OMAiDATGMME.
OrthoDBiEOG7JHM8S.
PhylomeDBiQ9Y2B9.
TreeFamiTF330809.

Miscellaneous databases

ChiTaRSiPKIG. human.
GeneWikiiPKIG.
GenomeRNAii11142.
NextBioi42352.
PROiQ9Y2B9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y2B9.
CleanExiHS_PKIG.
ExpressionAtlasiQ9Y2B9. baseline and differential.
GenevestigatoriQ9Y2B9.

Family and domain databases

InterProiIPR004171. cAMP_dep_PKI.
[Graphical view]
PfamiPF02827. PKI. 1 hit.
[Graphical view]
PIRSFiPIRSF001667. PKI. 1 hit.
ProDomiPD010366. cAMP_dep_PKI. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Protein kinase inhibitor gamma mRNA, complete cds."
    Saito T., Miyajima N.
    Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Characterization of PKI-gamma, a novel isoform of the protein kinase inhibitor of cAMP-dependent protein kinase."
    Collins S.P., Uhler M.D.
    J. Biol. Chem. 272:18169-18178(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Parathyroid.
  3. "Cloning and mapping of human PKIB and PKIG, and comparison of tissue expression patterns of three members of the protein kinase inhibitor family, including PKIA."
    Zheng L., Yu L., Tu Q., Zhang M., He H., Chen W., Gao J., Yu J., Wu Q., Zhao S.
    Biochem. J. 349:403-407(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiIPKG_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2B9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2000
Last sequence update: October 31, 1999
Last modified: February 3, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.