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Protein

TP53-target gene 5 protein

Gene

TP53TG5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a significant role in p53/TP53-mediating signaling pathway.1 Publication

GO - Biological processi

  • intracellular signal transduction Source: UniProtKB
  • negative regulation of cell growth Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
TP53-target gene 5 protein
Alternative name(s):
TP53-inducible gene 5 protein
Gene namesi
Name:TP53TG5
Synonyms:C20orf10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:15856. TP53TG5.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25639.

Polymorphism and mutation databases

BioMutaiTP53TG5.
DMDMi23822283.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 290290TP53-target gene 5 proteinPRO_0000072405Add
BLAST

Proteomic databases

EPDiQ9Y2B4.
PaxDbiQ9Y2B4.
PeptideAtlasiQ9Y2B4.
PRIDEiQ9Y2B4.

PTM databases

iPTMnetiQ9Y2B4.
PhosphoSiteiQ9Y2B4.

Expressioni

Tissue specificityi

Highly expressed in heart, brain and small intestine. Less abundant in skeletal muscle, spleen, prostate, ovary and colon. A smaller transcript is expressed specifically in the testis.1 Publication

Inductioni

By p53/TP53, UV irradiation, by hydrogen peroxide treatment or by treatment with a DNA-damaging reagent.1 Publication

Gene expression databases

BgeeiQ9Y2B4.
CleanExiHS_TP53TG5.
GenevisibleiQ9Y2B4. HS.

Organism-specific databases

HPAiHPA041979.

Interactioni

Subunit structurei

Interacts with p53/TP53.1 Publication

Protein-protein interaction databases

BioGridi118120. 5 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2B4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IKVF. Eukaryota.
ENOG4111BJ4. LUCA.
GeneTreeiENSGT00390000017387.
HOGENOMiHOG000152368.
HOVERGENiHBG076766.
InParanoidiQ9Y2B4.
OMAiIWFEGLP.
OrthoDBiEOG7C5MBN.
PhylomeDBiQ9Y2B4.
TreeFamiTF337759.

Family and domain databases

InterProiIPR029290. TP53TG5.
[Graphical view]
PANTHERiPTHR15562. PTHR15562. 1 hit.
PfamiPF15331. TP53IP5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y2B4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPSAKKRPK NSRVSKMQDE KLRDETEQPV SKVIERNRLR TVLKNLSLLK
60 70 80 90 100
LLKSSNRRIQ ELHKLAKRCW HSLLSVPKIL RISSGENSAC NKTKQNNEEF
110 120 130 140 150
QEIGCSEKEL KSKKLESTGD PKKKEYKEWK SQVQSGMRNK EKTSLAAMPR
160 170 180 190 200
KEKHIEPEVP RTSRDDSLNP GVQGRQPLTE GPRVIFIKPY RNRTPMGHMK
210 220 230 240 250
QLDVADQWIW FEGLPTRIHL PAPRVMCRSS TLRWVKRRCT RFCSASLEMP
260 270 280 290
MWHPYKVDVT WTRARGASRG WRSRHQLKGR NGWRNSRVYK
Length:290
Mass (Da):34,019
Last modified:November 1, 1999 - v1
Checksum:iD3206C95021473E3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti57 – 571R → H.
Corresponds to variant rs2231616 [ dbSNP | Ensembl ].
VAR_051397
Natural varianti172 – 1721V → A.
Corresponds to variant rs2231619 [ dbSNP | Ensembl ].
VAR_051398
Natural varianti191 – 1911R → H.
Corresponds to variant rs2231620 [ dbSNP | Ensembl ].
VAR_051399
Natural varianti219 – 2191H → Q.
Corresponds to variant rs2231622 [ dbSNP | Ensembl ].
VAR_051400
Natural varianti221 – 2211P → L.
Corresponds to variant rs2231623 [ dbSNP | Ensembl ].
VAR_051401
Natural varianti257 – 2571V → A.
Corresponds to variant rs2231627 [ dbSNP | Ensembl ].
VAR_051402
Natural varianti275 – 2751H → N.
Corresponds to variant rs2231628 [ dbSNP | Ensembl ].
VAR_051403

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017802 mRNA. Translation: BAA76405.1.
AL021578 Genomic DNA. Translation: CAC18107.1.
BC036785 mRNA. Translation: AAH36785.1.
CCDSiCCDS13352.1.
RefSeqiNP_055292.1. NM_014477.2.
UniGeneiHs.710271.

Genome annotation databases

EnsembliENST00000372726; ENSP00000361811; ENSG00000124251.
GeneIDi27296.
KEGGihsa:27296.
UCSCiuc002xny.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017802 mRNA. Translation: BAA76405.1.
AL021578 Genomic DNA. Translation: CAC18107.1.
BC036785 mRNA. Translation: AAH36785.1.
CCDSiCCDS13352.1.
RefSeqiNP_055292.1. NM_014477.2.
UniGeneiHs.710271.

3D structure databases

ProteinModelPortaliQ9Y2B4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118120. 5 interactions.

PTM databases

iPTMnetiQ9Y2B4.
PhosphoSiteiQ9Y2B4.

Polymorphism and mutation databases

BioMutaiTP53TG5.
DMDMi23822283.

Proteomic databases

EPDiQ9Y2B4.
PaxDbiQ9Y2B4.
PeptideAtlasiQ9Y2B4.
PRIDEiQ9Y2B4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372726; ENSP00000361811; ENSG00000124251.
GeneIDi27296.
KEGGihsa:27296.
UCSCiuc002xny.4. human.

Organism-specific databases

CTDi27296.
GeneCardsiTP53TG5.
HGNCiHGNC:15856. TP53TG5.
HPAiHPA041979.
neXtProtiNX_Q9Y2B4.
PharmGKBiPA25639.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKVF. Eukaryota.
ENOG4111BJ4. LUCA.
GeneTreeiENSGT00390000017387.
HOGENOMiHOG000152368.
HOVERGENiHBG076766.
InParanoidiQ9Y2B4.
OMAiIWFEGLP.
OrthoDBiEOG7C5MBN.
PhylomeDBiQ9Y2B4.
TreeFamiTF337759.

Miscellaneous databases

GenomeRNAii27296.
PROiQ9Y2B4.

Gene expression databases

BgeeiQ9Y2B4.
CleanExiHS_TP53TG5.
GenevisibleiQ9Y2B4. HS.

Family and domain databases

InterProiIPR029290. TP53TG5.
[Graphical view]
PANTHERiPTHR15562. PTHR15562. 1 hit.
PfamiPF15331. TP53IP5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of a novel TP53-inducible gene, TP53TG5, which suppresses growth and shows cell cycle-dependent transition of expression."
    Isaka S., Takei Y., Tokino T., Koyama K., Miyoshi Y., Suzuki M., Takahashi E., Azuma C., Murata Y., Nakamura Y.
    Genes Chromosomes Cancer 27:345-352(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH TP53, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION.
    Tissue: Testis.
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiT53G5_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2B4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: November 1, 1999
Last modified: July 6, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.