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Protein

TP53-target gene 5 protein

Gene

TP53TG5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a significant role in p53/TP53-mediating signaling pathway.1 Publication

GO - Biological processi

  • intracellular signal transduction Source: UniProtKB
  • negative regulation of cell growth Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
TP53-target gene 5 protein
Alternative name(s):
TP53-inducible gene 5 protein
Gene namesi
Name:TP53TG5
Synonyms:C20orf10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000124251.10
HGNCiHGNC:15856 TP53TG5
MIMi617316 gene
neXtProtiNX_Q9Y2B4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000124251
PharmGKBiPA25639

Polymorphism and mutation databases

BioMutaiTP53TG5
DMDMi23822283

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000724051 – 290TP53-target gene 5 proteinAdd BLAST290

Proteomic databases

PaxDbiQ9Y2B4
PeptideAtlasiQ9Y2B4
PRIDEiQ9Y2B4
ProteomicsDBi85719

PTM databases

iPTMnetiQ9Y2B4
PhosphoSitePlusiQ9Y2B4

Expressioni

Tissue specificityi

Highly expressed in heart, brain and small intestine. Less abundant in skeletal muscle, spleen, prostate, ovary and colon. A smaller transcript is expressed specifically in the testis.1 Publication

Inductioni

By p53/TP53, UV irradiation, by hydrogen peroxide treatment or by treatment with a DNA-damaging reagent.1 Publication

Gene expression databases

BgeeiENSG00000124251
CleanExiHS_TP53TG5
GenevisibleiQ9Y2B4 HS

Organism-specific databases

HPAiHPA041979

Interactioni

Subunit structurei

Interacts with p53/TP53.1 Publication

Protein-protein interaction databases

BioGridi118120, 6 interactors

Structurei

3D structure databases

ProteinModelPortaliQ9Y2B4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IKVF Eukaryota
ENOG4111BJ4 LUCA
GeneTreeiENSGT00390000017387
HOGENOMiHOG000152368
HOVERGENiHBG076766
InParanoidiQ9Y2B4
OMAiIWFEGLP
OrthoDBiEOG091G107D
PhylomeDBiQ9Y2B4
TreeFamiTF337759

Family and domain databases

InterProiView protein in InterPro
IPR029290 TP53TG5
PANTHERiPTHR15562 PTHR15562, 1 hit
PfamiView protein in Pfam
PF15331 TP53IP5, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Y2B4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPSAKKRPK NSRVSKMQDE KLRDETEQPV SKVIERNRLR TVLKNLSLLK
60 70 80 90 100
LLKSSNRRIQ ELHKLAKRCW HSLLSVPKIL RISSGENSAC NKTKQNNEEF
110 120 130 140 150
QEIGCSEKEL KSKKLESTGD PKKKEYKEWK SQVQSGMRNK EKTSLAAMPR
160 170 180 190 200
KEKHIEPEVP RTSRDDSLNP GVQGRQPLTE GPRVIFIKPY RNRTPMGHMK
210 220 230 240 250
QLDVADQWIW FEGLPTRIHL PAPRVMCRSS TLRWVKRRCT RFCSASLEMP
260 270 280 290
MWHPYKVDVT WTRARGASRG WRSRHQLKGR NGWRNSRVYK
Length:290
Mass (Da):34,019
Last modified:November 1, 1999 - v1
Checksum:iD3206C95021473E3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05139757R → H. Corresponds to variant dbSNP:rs2231616Ensembl.1
Natural variantiVAR_051398172V → A. Corresponds to variant dbSNP:rs2231619Ensembl.1
Natural variantiVAR_051399191R → H. Corresponds to variant dbSNP:rs2231620Ensembl.1
Natural variantiVAR_051400219H → Q. Corresponds to variant dbSNP:rs2231622Ensembl.1
Natural variantiVAR_051401221P → L. Corresponds to variant dbSNP:rs2231623Ensembl.1
Natural variantiVAR_051402257V → A. Corresponds to variant dbSNP:rs2231627Ensembl.1
Natural variantiVAR_051403275H → N. Corresponds to variant dbSNP:rs2231628Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017802 mRNA Translation: BAA76405.1
AL021578 Genomic DNA No translation available.
BC036785 mRNA Translation: AAH36785.1
CCDSiCCDS13352.1
RefSeqiNP_055292.1, NM_014477.2
UniGeneiHs.710271

Genome annotation databases

EnsembliENST00000372726; ENSP00000361811; ENSG00000124251
GeneIDi27296
KEGGihsa:27296
UCSCiuc002xny.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiT53G5_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2B4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: November 1, 1999
Last modified: June 20, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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