Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9Y2B0

- CNPY2_HUMAN

UniProt

Q9Y2B0 - CNPY2_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Protein canopy homolog 2

Gene

CNPY2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation.

GO - Biological processi

  1. negative regulation of gene expression Source: BHF-UCL
  2. positive regulation of low-density lipoprotein particle receptor biosynthetic process Source: BHF-UCL
  3. regulation of low-density lipoprotein particle clearance Source: BHF-UCL
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein canopy homolog 2
Alternative name(s):
MIR-interacting saposin-like protein
Putative secreted protein Zsig9
Transmembrane protein 4
Gene namesi
Name:CNPY2
Synonyms:MSAP, TMEM4, ZSIG9
ORF Names:UNQ1943/PRO4426
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:13529. CNPY2.

Subcellular locationi

Endoplasmic reticulum PROSITE-ProRule annotation

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162382584.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 182162Protein canopy homolog 2PRO_0000031666Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi28 ↔ 171PROSITE-ProRule annotation
Disulfide bondi31 ↔ 164PROSITE-ProRule annotation
Disulfide bondi86 ↔ 137PROSITE-ProRule annotation
Modified residuei115 – 1151PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

MaxQBiQ9Y2B0.
PaxDbiQ9Y2B0.
PeptideAtlasiQ9Y2B0.
PRIDEiQ9Y2B0.

PTM databases

PhosphoSiteiQ9Y2B0.

Expressioni

Tissue specificityi

Expressed in different tissues. Highest levels are detected in adult placenta, liver and pancreas.1 Publication

Gene expression databases

BgeeiQ9Y2B0.
CleanExiHS_CNPY2.
ExpressionAtlasiQ9Y2B0. baseline and differential.
GenevestigatoriQ9Y2B0.

Organism-specific databases

HPAiHPA038465.
HPA038466.

Interactioni

Subunit structurei

Interacts with MYLIP/MIR.1 Publication

Protein-protein interaction databases

BioGridi115613. 3 interactions.
DIPiDIP-50705N.
IntActiQ9Y2B0. 1 interaction.
MINTiMINT-3084309.
STRINGi9606.ENSP00000273308.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2B0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 175152Saposin B-typePROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi179 – 1824Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the canopy family.Curated
Contains 1 saposin B-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG280279.
GeneTreeiENSGT00390000009749.
HOGENOMiHOG000233996.
HOVERGENiHBG052514.
InParanoidiQ9Y2B0.
PhylomeDBiQ9Y2B0.
TreeFamiTF318578.

Family and domain databases

InterProiIPR021852. DUF3456.
IPR008139. SaposinB.
[Graphical view]
PfamiPF11938. DUF3456. 1 hit.
[Graphical view]
PROSITEiPS00014. ER_TARGET. 1 hit.
PS50015. SAP_B. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9Y2B0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKGWGWLALL LGALLGTAWA RRSQDLHCGA CRALVDELEW EIAQVDPKKT
60 70 80 90 100
IQMGSFRINP DGSQSVVEVP YARSEAHLTE LLEEICDRMK EYGEQIDPST
110 120 130 140 150
HRKNYVRVVG RNGESSELDL QGIRIDSDIS GTLKFACESI VEEYEDELIE
160 170 180
FFSREADNVK DKLCSKRTDL CDHALHISHD EL
Length:182
Mass (Da):20,652
Last modified:November 1, 1999 - v1
Checksum:iBE726D302490733F
GO
Isoform 2 (identifier: Q9Y2B0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     70-84: PYARSEAHLTELLEE → TVTVPPNKVAHSGFG
     85-182: Missing.

Show »
Length:84
Mass (Da):9,117
Checksum:iDCA2B08EC77EF1F0
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei70 – 8415PYARS…ELLEE → TVTVPPNKVAHSGFG in isoform 2. 2 PublicationsVSP_010884Add
BLAST
Alternative sequencei85 – 18298Missing in isoform 2. 2 PublicationsVSP_010885Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB015631 mRNA. Translation: BAA76498.1.
AY032624 mRNA. Translation: AAK38148.1.
AF186113 mRNA. Translation: AAF01431.1.
AY359102 mRNA. Translation: AAQ89460.1.
AK312921 mRNA. Translation: BAG35766.1.
CH471054 Genomic DNA. Translation: EAW96926.1.
BC001027 mRNA. Translation: AAH01027.1.
BC065015 mRNA. Translation: AAH65015.1.
CCDSiCCDS8914.1. [Q9Y2B0-1]
RefSeqiNP_001177920.1. NM_001190991.1. [Q9Y2B0-2]
NP_055070.1. NM_014255.5. [Q9Y2B0-1]
UniGeneiHs.8752.

Genome annotation databases

EnsembliENST00000273308; ENSP00000273308; ENSG00000257727. [Q9Y2B0-1]
GeneIDi10330.
KEGGihsa:10330.
UCSCiuc001sku.2. human. [Q9Y2B0-1]
uc001skv.3. human. [Q9Y2B0-2]

Polymorphism databases

DMDMi50401205.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB015631 mRNA. Translation: BAA76498.1 .
AY032624 mRNA. Translation: AAK38148.1 .
AF186113 mRNA. Translation: AAF01431.1 .
AY359102 mRNA. Translation: AAQ89460.1 .
AK312921 mRNA. Translation: BAG35766.1 .
CH471054 Genomic DNA. Translation: EAW96926.1 .
BC001027 mRNA. Translation: AAH01027.1 .
BC065015 mRNA. Translation: AAH65015.1 .
CCDSi CCDS8914.1. [Q9Y2B0-1 ]
RefSeqi NP_001177920.1. NM_001190991.1. [Q9Y2B0-2 ]
NP_055070.1. NM_014255.5. [Q9Y2B0-1 ]
UniGenei Hs.8752.

3D structure databases

ProteinModelPortali Q9Y2B0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115613. 3 interactions.
DIPi DIP-50705N.
IntActi Q9Y2B0. 1 interaction.
MINTi MINT-3084309.
STRINGi 9606.ENSP00000273308.

PTM databases

PhosphoSitei Q9Y2B0.

Polymorphism databases

DMDMi 50401205.

Proteomic databases

MaxQBi Q9Y2B0.
PaxDbi Q9Y2B0.
PeptideAtlasi Q9Y2B0.
PRIDEi Q9Y2B0.

Protocols and materials databases

DNASUi 10330.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000273308 ; ENSP00000273308 ; ENSG00000257727 . [Q9Y2B0-1 ]
GeneIDi 10330.
KEGGi hsa:10330.
UCSCi uc001sku.2. human. [Q9Y2B0-1 ]
uc001skv.3. human. [Q9Y2B0-2 ]

Organism-specific databases

CTDi 10330.
GeneCardsi GC12M056704.
HGNCi HGNC:13529. CNPY2.
HPAi HPA038465.
HPA038466.
MIMi 605861. gene.
neXtProti NX_Q9Y2B0.
PharmGKBi PA162382584.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG280279.
GeneTreei ENSGT00390000009749.
HOGENOMi HOG000233996.
HOVERGENi HBG052514.
InParanoidi Q9Y2B0.
PhylomeDBi Q9Y2B0.
TreeFami TF318578.

Miscellaneous databases

ChiTaRSi CNPY2. human.
GenomeRNAii 10330.
NextBioi 39165.
PROi Q9Y2B0.
SOURCEi Search...

Gene expression databases

Bgeei Q9Y2B0.
CleanExi HS_CNPY2.
ExpressionAtlasi Q9Y2B0. baseline and differential.
Genevestigatori Q9Y2B0.

Family and domain databases

InterProi IPR021852. DUF3456.
IPR008139. SaposinB.
[Graphical view ]
Pfami PF11938. DUF3456. 1 hit.
[Graphical view ]
PROSITEi PS00014. ER_TARGET. 1 hit.
PS50015. SAP_B. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank."
    Yokoyama-Kobayashi M., Yamaguchi T., Sekine S., Kato S.
    Gene 228:161-167(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Gastric adenocarcinoma.
  2. "MSAP is a novel MIR-interacting protein that enhances neurite outgrowth and increases myosin regulatory light chain."
    Bornhauser B.C., Olsson P.-A., Lindholm D.
    J. Biol. Chem. 278:35412-35420(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH MYLIP, TISSUE SPECIFICITY.
  3. "Homo sapiens putative secreted protein."
    Sheppard P., Jelinek L., Whitmore T., Blumberg H., Lehner J., O'Hara P.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Eye and Skin.

Entry informationi

Entry nameiCNPY2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2B0
Secondary accession number(s): B2R7B9, Q9UHE9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: November 1, 1999
Last modified: October 29, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3