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Q9Y2B0

- CNPY2_HUMAN

UniProt

Q9Y2B0 - CNPY2_HUMAN

Protein

Protein canopy homolog 2

Gene

CNPY2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation.

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. negative regulation of gene expression Source: BHF-UCL
    2. positive regulation of low-density lipoprotein particle receptor biosynthetic process Source: BHF-UCL
    3. regulation of low-density lipoprotein particle clearance Source: BHF-UCL

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein canopy homolog 2
    Alternative name(s):
    MIR-interacting saposin-like protein
    Putative secreted protein Zsig9
    Transmembrane protein 4
    Gene namesi
    Name:CNPY2
    Synonyms:MSAP, TMEM4, ZSIG9
    ORF Names:UNQ1943/PRO4426
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:13529. CNPY2.

    Subcellular locationi

    Endoplasmic reticulum PROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB-SubCell
    2. integral component of plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Endoplasmic reticulum

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162382584.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 182162Protein canopy homolog 2PRO_0000031666Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi28 ↔ 171PROSITE-ProRule annotation
    Disulfide bondi31 ↔ 164PROSITE-ProRule annotation
    Disulfide bondi86 ↔ 137PROSITE-ProRule annotation
    Modified residuei115 – 1151PhosphoserineBy similarity

    Keywords - PTMi

    Disulfide bond, Phosphoprotein

    Proteomic databases

    MaxQBiQ9Y2B0.
    PaxDbiQ9Y2B0.
    PeptideAtlasiQ9Y2B0.
    PRIDEiQ9Y2B0.

    PTM databases

    PhosphoSiteiQ9Y2B0.

    Expressioni

    Tissue specificityi

    Expressed in different tissues. Highest levels are detected in adult placenta, liver and pancreas.1 Publication

    Gene expression databases

    ArrayExpressiQ9Y2B0.
    BgeeiQ9Y2B0.
    CleanExiHS_CNPY2.
    GenevestigatoriQ9Y2B0.

    Organism-specific databases

    HPAiHPA038465.
    HPA038466.

    Interactioni

    Subunit structurei

    Interacts with MYLIP/MIR.1 Publication

    Protein-protein interaction databases

    BioGridi115613. 3 interactions.
    DIPiDIP-50705N.
    IntActiQ9Y2B0. 1 interaction.
    MINTiMINT-3084309.
    STRINGi9606.ENSP00000273308.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y2B0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 175152Saposin B-typePROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi179 – 1824Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the canopy family.Curated
    Contains 1 saposin B-type domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG280279.
    HOGENOMiHOG000233996.
    HOVERGENiHBG052514.
    InParanoidiQ9Y2B0.
    PhylomeDBiQ9Y2B0.
    TreeFamiTF318578.

    Family and domain databases

    InterProiIPR021852. DUF3456.
    IPR008139. SaposinB.
    [Graphical view]
    PfamiPF11938. DUF3456. 1 hit.
    [Graphical view]
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS50015. SAP_B. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y2B0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKGWGWLALL LGALLGTAWA RRSQDLHCGA CRALVDELEW EIAQVDPKKT    50
    IQMGSFRINP DGSQSVVEVP YARSEAHLTE LLEEICDRMK EYGEQIDPST 100
    HRKNYVRVVG RNGESSELDL QGIRIDSDIS GTLKFACESI VEEYEDELIE 150
    FFSREADNVK DKLCSKRTDL CDHALHISHD EL 182
    Length:182
    Mass (Da):20,652
    Last modified:November 1, 1999 - v1
    Checksum:iBE726D302490733F
    GO
    Isoform 2 (identifier: Q9Y2B0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         70-84: PYARSEAHLTELLEE → TVTVPPNKVAHSGFG
         85-182: Missing.

    Show »
    Length:84
    Mass (Da):9,117
    Checksum:iDCA2B08EC77EF1F0
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei70 – 8415PYARS…ELLEE → TVTVPPNKVAHSGFG in isoform 2. 2 PublicationsVSP_010884Add
    BLAST
    Alternative sequencei85 – 18298Missing in isoform 2. 2 PublicationsVSP_010885Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB015631 mRNA. Translation: BAA76498.1.
    AY032624 mRNA. Translation: AAK38148.1.
    AF186113 mRNA. Translation: AAF01431.1.
    AY359102 mRNA. Translation: AAQ89460.1.
    AK312921 mRNA. Translation: BAG35766.1.
    CH471054 Genomic DNA. Translation: EAW96926.1.
    BC001027 mRNA. Translation: AAH01027.1.
    BC065015 mRNA. Translation: AAH65015.1.
    CCDSiCCDS8914.1. [Q9Y2B0-1]
    RefSeqiNP_001177920.1. NM_001190991.1. [Q9Y2B0-2]
    NP_055070.1. NM_014255.5. [Q9Y2B0-1]
    UniGeneiHs.8752.

    Genome annotation databases

    EnsembliENST00000273308; ENSP00000273308; ENSG00000257727. [Q9Y2B0-1]
    GeneIDi10330.
    KEGGihsa:10330.
    UCSCiuc001sku.2. human. [Q9Y2B0-1]
    uc001skv.3. human. [Q9Y2B0-2]

    Polymorphism databases

    DMDMi50401205.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB015631 mRNA. Translation: BAA76498.1 .
    AY032624 mRNA. Translation: AAK38148.1 .
    AF186113 mRNA. Translation: AAF01431.1 .
    AY359102 mRNA. Translation: AAQ89460.1 .
    AK312921 mRNA. Translation: BAG35766.1 .
    CH471054 Genomic DNA. Translation: EAW96926.1 .
    BC001027 mRNA. Translation: AAH01027.1 .
    BC065015 mRNA. Translation: AAH65015.1 .
    CCDSi CCDS8914.1. [Q9Y2B0-1 ]
    RefSeqi NP_001177920.1. NM_001190991.1. [Q9Y2B0-2 ]
    NP_055070.1. NM_014255.5. [Q9Y2B0-1 ]
    UniGenei Hs.8752.

    3D structure databases

    ProteinModelPortali Q9Y2B0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115613. 3 interactions.
    DIPi DIP-50705N.
    IntActi Q9Y2B0. 1 interaction.
    MINTi MINT-3084309.
    STRINGi 9606.ENSP00000273308.

    PTM databases

    PhosphoSitei Q9Y2B0.

    Polymorphism databases

    DMDMi 50401205.

    Proteomic databases

    MaxQBi Q9Y2B0.
    PaxDbi Q9Y2B0.
    PeptideAtlasi Q9Y2B0.
    PRIDEi Q9Y2B0.

    Protocols and materials databases

    DNASUi 10330.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000273308 ; ENSP00000273308 ; ENSG00000257727 . [Q9Y2B0-1 ]
    GeneIDi 10330.
    KEGGi hsa:10330.
    UCSCi uc001sku.2. human. [Q9Y2B0-1 ]
    uc001skv.3. human. [Q9Y2B0-2 ]

    Organism-specific databases

    CTDi 10330.
    GeneCardsi GC12M056704.
    HGNCi HGNC:13529. CNPY2.
    HPAi HPA038465.
    HPA038466.
    MIMi 605861. gene.
    neXtProti NX_Q9Y2B0.
    PharmGKBi PA162382584.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG280279.
    HOGENOMi HOG000233996.
    HOVERGENi HBG052514.
    InParanoidi Q9Y2B0.
    PhylomeDBi Q9Y2B0.
    TreeFami TF318578.

    Miscellaneous databases

    ChiTaRSi CNPY2. human.
    GenomeRNAii 10330.
    NextBioi 39165.
    PROi Q9Y2B0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y2B0.
    Bgeei Q9Y2B0.
    CleanExi HS_CNPY2.
    Genevestigatori Q9Y2B0.

    Family and domain databases

    InterProi IPR021852. DUF3456.
    IPR008139. SaposinB.
    [Graphical view ]
    Pfami PF11938. DUF3456. 1 hit.
    [Graphical view ]
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS50015. SAP_B. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank."
      Yokoyama-Kobayashi M., Yamaguchi T., Sekine S., Kato S.
      Gene 228:161-167(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Gastric adenocarcinoma.
    2. "MSAP is a novel MIR-interacting protein that enhances neurite outgrowth and increases myosin regulatory light chain."
      Bornhauser B.C., Olsson P.-A., Lindholm D.
      J. Biol. Chem. 278:35412-35420(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH MYLIP, TISSUE SPECIFICITY.
    3. "Homo sapiens putative secreted protein."
      Sheppard P., Jelinek L., Whitmore T., Blumberg H., Lehner J., O'Hara P.
      Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Eye and Skin.

    Entry informationi

    Entry nameiCNPY2_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y2B0
    Secondary accession number(s): B2R7B9, Q9UHE9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3