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Q9Y2A9

- B3GN3_HUMAN

UniProt

Q9Y2A9 - B3GN3_HUMAN

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Protein

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3

Gene

B3GNT3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Has a beta-1,3-N-acetylglucosaminyltransferase activity for type 2 oligosaccharides.1 Publication

Catalytic activityi

UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->3)-(N-acetyl-D-glucosaminyl-(1->6))-N-acetyl-D-galactosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-(N-acetyl-D-glucosaminyl-(1->6))-N-acetyl-D-galactosaminyl-R.1 Publication

Pathwayi

GO - Molecular functioni

  1. beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity Source: UniProtKB-EC
  2. galactosyltransferase activity Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: Reactome
  2. cellular protein metabolic process Source: Reactome
  3. glycosaminoglycan metabolic process Source: Reactome
  4. keratan sulfate biosynthetic process Source: Reactome
  5. keratan sulfate metabolic process Source: Reactome
  6. O-glycan processing Source: Reactome
  7. post-translational protein modification Source: Reactome
  8. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000179913-MONOMER.
BRENDAi2.4.1.146. 2681.
ReactomeiREACT_115606. O-linked glycosylation of mucins.
REACT_121120. Keratan sulfate biosynthesis.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT31. Glycosyltransferase Family 31.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 (EC:2.4.1.146)
Short name:
BGnT-3
Short name:
Beta-1,3-Gn-T3
Short name:
Beta-1,3-N-acetylglucosaminyltransferase 3
Short name:
Beta3Gn-T3
Alternative name(s):
Beta-1,3-galactosyltransferase 8
Short name:
Beta-1,3-GalTase 8
Short name:
Beta3Gal-T8
Short name:
Beta3GalT8
Short name:
b3Gal-T8
Beta-3-Gx-T8
Core 1 extending beta-1,3-N-acetylglucosaminyltransferase
Core1-beta3GlcNAcT
Transmembrane protein 3
UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 8
UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 8
Gene namesi
Name:B3GNT3
Synonyms:B3GALT8, TMEM3
ORF Names:UNQ637/PRO1266
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:13528. B3GNT3.

Subcellular locationi

GO - Cellular componenti

  1. Golgi membrane Source: Reactome
  2. integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25219.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 372372UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3PRO_0000219172Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi64 – 641N-linked (GlcNAc...)Sequence Analysis
Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence Analysis
Glycosylationi202 – 2021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi362 – 3621N-linked (GlcNAc...)Sequence Analysis
Glycosylationi367 – 3671N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9Y2A9.
PaxDbiQ9Y2A9.
PRIDEiQ9Y2A9.

PTM databases

PhosphoSiteiQ9Y2A9.

Expressioni

Tissue specificityi

Expressed in colon, jejunum, stomach, esophagus, placenta and trachea.1 Publication

Gene expression databases

BgeeiQ9Y2A9.
CleanExiHS_B3GNT3.
ExpressionAtlasiQ9Y2A9. baseline and differential.
GenevestigatoriQ9Y2A9.

Organism-specific databases

HPAiHPA024298.

Interactioni

Protein-protein interaction databases

BioGridi115614. 20 interactions.
STRINGi9606.ENSP00000321874.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2A9.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010CytoplasmicSequence Analysis
Topological domaini32 – 372341LumenalSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei11 – 3121Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 31 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG293830.
GeneTreeiENSGT00760000118879.
HOGENOMiHOG000232195.
HOVERGENiHBG050653.
InParanoidiQ9Y2A9.
KOiK07970.
OMAiCAQPVFL.
PhylomeDBiQ9Y2A9.
TreeFamiTF318639.

Family and domain databases

InterProiIPR002659. Glyco_trans_31.
[Graphical view]
PANTHERiPTHR11214. PTHR11214. 1 hit.
PfamiPF01762. Galactosyl_T. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y2A9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKYLRHRRPN ATLILAIGAF TLLLFSLLVS PPTCKVQEQP PAIPEALAWP
60 70 80 90 100
TPPTRPAPAP CHANTSMVTH PDFATQPQHV QNFLLYRHCR HFPLLQDVPP
110 120 130 140 150
SKCAQPVFLL LVIKSSPSNY VRRELLRRTW GRERKVRGLQ LRLLFLVGTA
160 170 180 190 200
SNPHEARKVN RLLELEAQTH GDILQWDFHD SFFNLTLKQV LFLQWQETRC
210 220 230 240 250
ANASFVLNGD DDVFAHTDNM VFYLQDHDPG RHLFVGQLIQ NVGPIRAFWS
260 270 280 290 300
KYYVPEVVTQ NERYPPYCGG GGFLLSRFTA AALRRAAHVL DIFPIDDVFL
310 320 330 340 350
GMCLELEGLK PASHSGIRTS GVRAPSQRLS SFDPCFYRDL LLVHRFLPYE
360 370
MLLMWDALNQ PNLTCGNQTQ IY
Length:372
Mass (Da):42,534
Last modified:November 2, 2010 - v2
Checksum:iA6E3FE88B2F00F10
GO

Sequence cautioni

The sequence CAC82374.1 differs from that shown. Reason: Frameshift at positions 194, 196, 202, 204, 209 and 215.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti89 – 891C → Y in AAH66876. (PubMed:15489334)Curated
Sequence conflicti355 – 3551W → R in AAH67423. (PubMed:15489334)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti328 – 3281R → H.6 Publications
Corresponds to variant rs36686 [ dbSNP | Ensembl ].
VAR_022644

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB015630 mRNA. Translation: BAA76497.1.
AF293973 mRNA. Translation: AAK00849.1.
AB049585 mRNA. Translation: BAB21531.1.
AJ130847 mRNA. Translation: CAC45044.1.
AJ278961 mRNA. Translation: CAC82374.1. Frameshift.
AY358955 mRNA. Translation: AAQ89314.1.
AK314323 mRNA. Translation: BAG36971.1.
AC008761 Genomic DNA. No translation available.
BC066876 mRNA. Translation: AAH66876.1.
BC067423 mRNA. Translation: AAH67423.1.
CCDSiCCDS12364.1.
RefSeqiNP_055071.2. NM_014256.3.
UniGeneiHs.657825.
Hs.69009.

Genome annotation databases

EnsembliENST00000318683; ENSP00000321874; ENSG00000179913.
ENST00000595387; ENSP00000472638; ENSG00000179913.
GeneIDi10331.
KEGGihsa:10331.
UCSCiuc002nhl.1. human.

Polymorphism databases

DMDMi311033352.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

GGDB

GlycoGene database

Functional Glycomics Gateway - GTase

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB015630 mRNA. Translation: BAA76497.1 .
AF293973 mRNA. Translation: AAK00849.1 .
AB049585 mRNA. Translation: BAB21531.1 .
AJ130847 mRNA. Translation: CAC45044.1 .
AJ278961 mRNA. Translation: CAC82374.1 . Frameshift.
AY358955 mRNA. Translation: AAQ89314.1 .
AK314323 mRNA. Translation: BAG36971.1 .
AC008761 Genomic DNA. No translation available.
BC066876 mRNA. Translation: AAH66876.1 .
BC067423 mRNA. Translation: AAH67423.1 .
CCDSi CCDS12364.1.
RefSeqi NP_055071.2. NM_014256.3.
UniGenei Hs.657825.
Hs.69009.

3D structure databases

ProteinModelPortali Q9Y2A9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115614. 20 interactions.
STRINGi 9606.ENSP00000321874.

Protein family/group databases

CAZyi GT31. Glycosyltransferase Family 31.

PTM databases

PhosphoSitei Q9Y2A9.

Polymorphism databases

DMDMi 311033352.

Proteomic databases

MaxQBi Q9Y2A9.
PaxDbi Q9Y2A9.
PRIDEi Q9Y2A9.

Protocols and materials databases

DNASUi 10331.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000318683 ; ENSP00000321874 ; ENSG00000179913 .
ENST00000595387 ; ENSP00000472638 ; ENSG00000179913 .
GeneIDi 10331.
KEGGi hsa:10331.
UCSCi uc002nhl.1. human.

Organism-specific databases

CTDi 10331.
GeneCardsi GC19P017905.
HGNCi HGNC:13528. B3GNT3.
HPAi HPA024298.
MIMi 605863. gene.
neXtProti NX_Q9Y2A9.
PharmGKBi PA25219.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG293830.
GeneTreei ENSGT00760000118879.
HOGENOMi HOG000232195.
HOVERGENi HBG050653.
InParanoidi Q9Y2A9.
KOi K07970.
OMAi CAQPVFL.
PhylomeDBi Q9Y2A9.
TreeFami TF318639.

Enzyme and pathway databases

UniPathwayi UPA00378 .
BioCyci MetaCyc:ENSG00000179913-MONOMER.
BRENDAi 2.4.1.146. 2681.
Reactomei REACT_115606. O-linked glycosylation of mucins.
REACT_121120. Keratan sulfate biosynthesis.

Miscellaneous databases

GeneWikii Beta-1,3-N-acetylglucosaminyltransferase_3.
GenomeRNAii 10331.
NextBioi 39169.
PROi Q9Y2A9.
SOURCEi Search...

Gene expression databases

Bgeei Q9Y2A9.
CleanExi HS_B3GNT3.
ExpressionAtlasi Q9Y2A9. baseline and differential.
Genevestigatori Q9Y2A9.

Family and domain databases

InterProi IPR002659. Glyco_trans_31.
[Graphical view ]
PANTHERi PTHR11214. PTHR11214. 1 hit.
Pfami PF01762. Galactosyl_T. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank."
    Yokoyama-Kobayashi M., Yamaguchi T., Sekine S., Kato S.
    Gene 228:161-167(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT HIS-328.
  2. "Novel sulfated lymphocyte homing receptors and their control by a Core1 extension beta 1,3-N-acetylglucosaminyltransferase."
    Yeh J.-C., Hiraoka N., Petryniak B., Nakayama J., Ellies L.G., Rabuka D., Hindsgaul O., Marth J.D., Lowe J.B., Fakuda M.
    Cell 105:957-969(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT HIS-328.
  3. "Identification and characterization of three novel beta 1,3-N-acetylglucosaminyltransferases structurally related to the beta 1,3-galactosyltransferase family."
    Shiraishi N., Natsume A., Togayachi A., Endo T., Akashima T., Yamada Y., Imai N., Nakagawa S., Koizumi S., Sekine S., Narimatsu H., Sasaki K.
    J. Biol. Chem. 276:3498-3507(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CATALYTIC ACTIVITY, FUNCTION, TISSUE SPECIFICITY.
    Tissue: Gastric mucosa.
  4. "Cloning of a new member of the beta 1,3 galactosyltransferase family, b1,3Gal-T6."
    Jensen M.A., Bennett E.P.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT HIS-328.
  5. Bennett E.P.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT HIS-328.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT HIS-328.
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  8. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT HIS-328.
  10. "Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions."
    Amado M., Almeida R., Schwientek T., Clausen H.
    Biochim. Biophys. Acta 1473:35-53(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiB3GN3_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2A9
Secondary accession number(s): B2RAS4
, Q6NWU9, Q6NXU9, Q8WWR6, Q9C0J2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 2, 2010
Last modified: October 29, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3