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Q9Y2A9

- B3GN3_HUMAN

UniProt

Q9Y2A9 - B3GN3_HUMAN

Protein

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3

Gene

B3GNT3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 2 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    Has a beta-1,3-N-acetylglucosaminyltransferase activity for type 2 oligosaccharides.1 Publication

    Catalytic activityi

    UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->3)-(N-acetyl-D-glucosaminyl-(1->6))-N-acetyl-D-galactosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-(N-acetyl-D-glucosaminyl-(1->6))-N-acetyl-D-galactosaminyl-R.1 Publication

    Pathwayi

    GO - Molecular functioni

    1. beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity Source: UniProtKB-EC
    2. galactosyltransferase activity Source: InterPro

    GO - Biological processi

    1. carbohydrate metabolic process Source: Reactome
    2. cellular protein metabolic process Source: Reactome
    3. glycosaminoglycan metabolic process Source: Reactome
    4. keratan sulfate biosynthetic process Source: Reactome
    5. keratan sulfate metabolic process Source: Reactome
    6. O-glycan processing Source: Reactome
    7. post-translational protein modification Source: Reactome
    8. small molecule metabolic process Source: Reactome

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    BioCyciMetaCyc:ENSG00000179913-MONOMER.
    BRENDAi2.4.1.146. 2681.
    ReactomeiREACT_115606. O-linked glycosylation of mucins.
    REACT_121120. Keratan sulfate biosynthesis.
    UniPathwayiUPA00378.

    Protein family/group databases

    CAZyiGT31. Glycosyltransferase Family 31.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 (EC:2.4.1.146)
    Short name:
    BGnT-3
    Short name:
    Beta-1,3-Gn-T3
    Short name:
    Beta-1,3-N-acetylglucosaminyltransferase 3
    Short name:
    Beta3Gn-T3
    Alternative name(s):
    Beta-1,3-galactosyltransferase 8
    Short name:
    Beta-1,3-GalTase 8
    Short name:
    Beta3Gal-T8
    Short name:
    Beta3GalT8
    Short name:
    b3Gal-T8
    Beta-3-Gx-T8
    Core 1 extending beta-1,3-N-acetylglucosaminyltransferase
    Core1-beta3GlcNAcT
    Transmembrane protein 3
    UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 8
    UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 8
    Gene namesi
    Name:B3GNT3
    Synonyms:B3GALT8, TMEM3
    ORF Names:UNQ637/PRO1266
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:13528. B3GNT3.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi membrane Source: Reactome
    2. integral component of plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25219.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 372372UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3PRO_0000219172Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi64 – 641N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi202 – 2021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi362 – 3621N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi367 – 3671N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ9Y2A9.
    PaxDbiQ9Y2A9.
    PRIDEiQ9Y2A9.

    PTM databases

    PhosphoSiteiQ9Y2A9.

    Expressioni

    Tissue specificityi

    Expressed in colon, jejunum, stomach, esophagus, placenta and trachea.1 Publication

    Gene expression databases

    ArrayExpressiQ9Y2A9.
    BgeeiQ9Y2A9.
    CleanExiHS_B3GNT3.
    GenevestigatoriQ9Y2A9.

    Organism-specific databases

    HPAiHPA024298.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000321874.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y2A9.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1010CytoplasmicSequence Analysis
    Topological domaini32 – 372341LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 3121Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 31 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG293830.
    HOGENOMiHOG000232195.
    HOVERGENiHBG050653.
    InParanoidiQ9Y2A9.
    KOiK07970.
    OMAiCAQPVFL.
    PhylomeDBiQ9Y2A9.
    TreeFamiTF318639.

    Family and domain databases

    InterProiIPR002659. Glyco_trans_31.
    [Graphical view]
    PANTHERiPTHR11214. PTHR11214. 1 hit.
    PfamiPF01762. Galactosyl_T. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Y2A9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKYLRHRRPN ATLILAIGAF TLLLFSLLVS PPTCKVQEQP PAIPEALAWP    50
    TPPTRPAPAP CHANTSMVTH PDFATQPQHV QNFLLYRHCR HFPLLQDVPP 100
    SKCAQPVFLL LVIKSSPSNY VRRELLRRTW GRERKVRGLQ LRLLFLVGTA 150
    SNPHEARKVN RLLELEAQTH GDILQWDFHD SFFNLTLKQV LFLQWQETRC 200
    ANASFVLNGD DDVFAHTDNM VFYLQDHDPG RHLFVGQLIQ NVGPIRAFWS 250
    KYYVPEVVTQ NERYPPYCGG GGFLLSRFTA AALRRAAHVL DIFPIDDVFL 300
    GMCLELEGLK PASHSGIRTS GVRAPSQRLS SFDPCFYRDL LLVHRFLPYE 350
    MLLMWDALNQ PNLTCGNQTQ IY 372
    Length:372
    Mass (Da):42,534
    Last modified:November 2, 2010 - v2
    Checksum:iA6E3FE88B2F00F10
    GO

    Sequence cautioni

    The sequence CAC82374.1 differs from that shown. Reason: Frameshift at positions 194, 196, 202, 204, 209 and 215.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti89 – 891C → Y in AAH66876. (PubMed:15489334)Curated
    Sequence conflicti355 – 3551W → R in AAH67423. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti328 – 3281R → H.6 Publications
    Corresponds to variant rs36686 [ dbSNP | Ensembl ].
    VAR_022644

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB015630 mRNA. Translation: BAA76497.1.
    AF293973 mRNA. Translation: AAK00849.1.
    AB049585 mRNA. Translation: BAB21531.1.
    AJ130847 mRNA. Translation: CAC45044.1.
    AJ278961 mRNA. Translation: CAC82374.1. Frameshift.
    AY358955 mRNA. Translation: AAQ89314.1.
    AK314323 mRNA. Translation: BAG36971.1.
    AC008761 Genomic DNA. No translation available.
    BC066876 mRNA. Translation: AAH66876.1.
    BC067423 mRNA. Translation: AAH67423.1.
    CCDSiCCDS12364.1.
    RefSeqiNP_055071.2. NM_014256.3.
    UniGeneiHs.657825.
    Hs.69009.

    Genome annotation databases

    EnsembliENST00000318683; ENSP00000321874; ENSG00000179913.
    ENST00000595387; ENSP00000472638; ENSG00000179913.
    GeneIDi10331.
    KEGGihsa:10331.
    UCSCiuc002nhl.1. human.

    Polymorphism databases

    DMDMi311033352.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    GGDB

    GlycoGene database

    Functional Glycomics Gateway - GTase

    UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB015630 mRNA. Translation: BAA76497.1 .
    AF293973 mRNA. Translation: AAK00849.1 .
    AB049585 mRNA. Translation: BAB21531.1 .
    AJ130847 mRNA. Translation: CAC45044.1 .
    AJ278961 mRNA. Translation: CAC82374.1 . Frameshift.
    AY358955 mRNA. Translation: AAQ89314.1 .
    AK314323 mRNA. Translation: BAG36971.1 .
    AC008761 Genomic DNA. No translation available.
    BC066876 mRNA. Translation: AAH66876.1 .
    BC067423 mRNA. Translation: AAH67423.1 .
    CCDSi CCDS12364.1.
    RefSeqi NP_055071.2. NM_014256.3.
    UniGenei Hs.657825.
    Hs.69009.

    3D structure databases

    ProteinModelPortali Q9Y2A9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000321874.

    Protein family/group databases

    CAZyi GT31. Glycosyltransferase Family 31.

    PTM databases

    PhosphoSitei Q9Y2A9.

    Polymorphism databases

    DMDMi 311033352.

    Proteomic databases

    MaxQBi Q9Y2A9.
    PaxDbi Q9Y2A9.
    PRIDEi Q9Y2A9.

    Protocols and materials databases

    DNASUi 10331.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000318683 ; ENSP00000321874 ; ENSG00000179913 .
    ENST00000595387 ; ENSP00000472638 ; ENSG00000179913 .
    GeneIDi 10331.
    KEGGi hsa:10331.
    UCSCi uc002nhl.1. human.

    Organism-specific databases

    CTDi 10331.
    GeneCardsi GC19P017905.
    HGNCi HGNC:13528. B3GNT3.
    HPAi HPA024298.
    MIMi 605863. gene.
    neXtProti NX_Q9Y2A9.
    PharmGKBi PA25219.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG293830.
    HOGENOMi HOG000232195.
    HOVERGENi HBG050653.
    InParanoidi Q9Y2A9.
    KOi K07970.
    OMAi CAQPVFL.
    PhylomeDBi Q9Y2A9.
    TreeFami TF318639.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .
    BioCyci MetaCyc:ENSG00000179913-MONOMER.
    BRENDAi 2.4.1.146. 2681.
    Reactomei REACT_115606. O-linked glycosylation of mucins.
    REACT_121120. Keratan sulfate biosynthesis.

    Miscellaneous databases

    GeneWikii Beta-1,3-N-acetylglucosaminyltransferase_3.
    GenomeRNAii 10331.
    NextBioi 39169.
    PROi Q9Y2A9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y2A9.
    Bgeei Q9Y2A9.
    CleanExi HS_B3GNT3.
    Genevestigatori Q9Y2A9.

    Family and domain databases

    InterProi IPR002659. Glyco_trans_31.
    [Graphical view ]
    PANTHERi PTHR11214. PTHR11214. 1 hit.
    Pfami PF01762. Galactosyl_T. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank."
      Yokoyama-Kobayashi M., Yamaguchi T., Sekine S., Kato S.
      Gene 228:161-167(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT HIS-328.
    2. "Novel sulfated lymphocyte homing receptors and their control by a Core1 extension beta 1,3-N-acetylglucosaminyltransferase."
      Yeh J.-C., Hiraoka N., Petryniak B., Nakayama J., Ellies L.G., Rabuka D., Hindsgaul O., Marth J.D., Lowe J.B., Fakuda M.
      Cell 105:957-969(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT HIS-328.
    3. "Identification and characterization of three novel beta 1,3-N-acetylglucosaminyltransferases structurally related to the beta 1,3-galactosyltransferase family."
      Shiraishi N., Natsume A., Togayachi A., Endo T., Akashima T., Yamada Y., Imai N., Nakagawa S., Koizumi S., Sekine S., Narimatsu H., Sasaki K.
      J. Biol. Chem. 276:3498-3507(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], CATALYTIC ACTIVITY, FUNCTION, TISSUE SPECIFICITY.
      Tissue: Gastric mucosa.
    4. "Cloning of a new member of the beta 1,3 galactosyltransferase family, b1,3Gal-T6."
      Jensen M.A., Bennett E.P.
      Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT HIS-328.
    5. Bennett E.P.
      Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT HIS-328.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT HIS-328.
    7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    8. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT HIS-328.
    10. "Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions."
      Amado M., Almeida R., Schwientek T., Clausen H.
      Biochim. Biophys. Acta 1473:35-53(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiB3GN3_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y2A9
    Secondary accession number(s): B2RAS4
    , Q6NWU9, Q6NXU9, Q8WWR6, Q9C0J2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 123 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3