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Protein

Zinc finger protein 443

Gene

ZNF443

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri134 – 159C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST26
Zinc fingeri169 – 191C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri197 – 219C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri225 – 247C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri253 – 275C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri281 – 303C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 331C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 359C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri365 – 387C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri393 – 415C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri421 – 443C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri449 – 471C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri477 – 498C2H2-type 13; degeneratePROSITE-ProRule annotationAdd BLAST22
Zinc fingeri504 – 526C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri532 – 554C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri560 – 582C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri588 – 610C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri616 – 638C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri649 – 671C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • apoptotic process Source: ProtInc
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • response to stress Source: ProtInc
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000123162-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 443
Alternative name(s):
Krueppel-type zinc finger protein ZK1
Gene namesi
Name:ZNF443
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:20878. ZNF443.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10224.
OpenTargetsiENSG00000180855.
PharmGKBiPA134968382.

Polymorphism and mutation databases

BioMutaiZNF443.
DMDMi296453041.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475921 – 671Zinc finger protein 443Add BLAST671

Proteomic databases

EPDiQ9Y2A4.
MaxQBiQ9Y2A4.
PaxDbiQ9Y2A4.
PeptideAtlasiQ9Y2A4.
PRIDEiQ9Y2A4.

PTM databases

iPTMnetiQ9Y2A4.
PhosphoSitePlusiQ9Y2A4.

Expressioni

Inductioni

Induced following exposure to ionizing radiation.

Gene expression databases

BgeeiENSG00000180855.
CleanExiHS_ZNF443.
ExpressionAtlasiQ9Y2A4. baseline and differential.
GenevisibleiQ9Y2A4. HS.

Organism-specific databases

HPAiHPA003150.
HPA018683.

Interactioni

Protein-protein interaction databases

BioGridi115518. 1 interactor.
IntActiQ9Y2A4. 1 interactor.
STRINGi9606.ENSP00000301547.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2A4.
SMRiQ9Y2A4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 86KRABPROSITE-ProRule annotationAdd BLAST83

Sequence similaritiesi

Contains 19 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri134 – 159C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST26
Zinc fingeri169 – 191C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri197 – 219C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri225 – 247C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri253 – 275C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri281 – 303C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 331C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 359C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri365 – 387C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri393 – 415C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri421 – 443C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri449 – 471C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri477 – 498C2H2-type 13; degeneratePROSITE-ProRule annotationAdd BLAST22
Zinc fingeri504 – 526C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri532 – 554C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri560 – 582C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri588 – 610C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri616 – 638C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri649 – 671C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOVERGENiHBG018163.
InParanoidiQ9Y2A4.
KOiK09228.
OMAiDSSSCLI.
OrthoDBiEOG091G02KC.
PhylomeDBiQ9Y2A4.
TreeFamiTF343410.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 19 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 4 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 19 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 16 hits.
PS50157. ZINC_FINGER_C2H2_2. 18 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y2A4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVALEDVA VNFTREEWAL LGPCQKNLYK DVMQETIRNL DCVVMKWKDQ
60 70 80 90 100
NIEDQYRYPR KNLRCRMLER FVESKDGTQC GETSSQIQDS IVTKNTLPGV
110 120 130 140 150
GPCESSMRGE KVMGHSSLNC YIRVGAGHKP HEYHECGEKP DTHKQRGKAF
160 170 180 190 200
SYHNSFQTHE RLHTGKKPYD CKECGKSFSS LGNLQRHMAV QRGDGPYKCK
210 220 230 240 250
LCGKAFFWPS LLHMHERTHT GEKPYECKQC SKAFSFYSSY LRHERTHTGE
260 270 280 290 300
KPYECKQCSK AFPFYSSYLR HERTHTGEKP YKCKQCSKAF PDSSSCLIHE
310 320 330 340 350
RTHTGEKPYT CKQCGKAFSV SGSLQRHETT HSAEKPYACQ QCGKAFHHLG
360 370 380 390 400
SFQRHMIRHT GNGPHKCKIC GKGFDCPSSL QSHERTHTGE KPYECKQCGK
410 420 430 440 450
ALSHRSSFRS HMIMHTGDGP HKCKVCGKAF VYPSVFQRHE RTHTAEKPYK
460 470 480 490 500
CKQCGKAYRI SSSLRRHETT HTGEKPYKCK LGKACIDFCS FQNHKTTHTG
510 520 530 540 550
EKPYECKECG KAFSRFRYLS RHKRTHTGEK PYECKTCRKA FGHYDNLKVH
560 570 580 590 600
ERIHSGEKPY ECKECGKAFS WLTCFLRHER IHMREKSYEC PQCGKAFTHS
610 620 630 640 650
RFLQGHEKTH TGENPYECKE CGKAFASLSS LHRHKKTHWK KTHTGENPYE
660 670
CKECGKAFAS LSSLHRHKKT H
Length:671
Mass (Da):77,516
Last modified:May 18, 2010 - v2
Checksum:iA715F816ADFD9A19
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti72V → I in BAA75543 (PubMed:9731181).Curated1
Sequence conflicti72V → I in AAH32753 (PubMed:15489334).Curated1
Sequence conflicti480K → T in BAA75543 (PubMed:9731181).Curated1
Sequence conflicti480K → T in AAH32753 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061947111K → I.Corresponds to variant rs28599549dbSNPEnsembl.1
Natural variantiVAR_059917111K → N.Corresponds to variant rs4239550dbSNPEnsembl.1
Natural variantiVAR_061948397Q → H.Corresponds to variant rs35699767dbSNPEnsembl.1
Natural variantiVAR_059918485C → F.2 PublicationsCorresponds to variant rs10422063dbSNPEnsembl.1
Natural variantiVAR_057420591P → Q.Corresponds to variant rs7256321dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011414 mRNA. Translation: BAA75543.1.
AC008758 Genomic DNA. No translation available.
BC032753 mRNA. Translation: AAH32753.1.
CCDSiCCDS32918.1.
PIRiJE0288.
RefSeqiNP_005806.2. NM_005815.4.
UniGeneiHs.636894.
Hs.720755.

Genome annotation databases

EnsembliENST00000301547; ENSP00000301547; ENSG00000180855.
GeneIDi10224.
KEGGihsa:10224.
UCSCiuc002mtu.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011414 mRNA. Translation: BAA75543.1.
AC008758 Genomic DNA. No translation available.
BC032753 mRNA. Translation: AAH32753.1.
CCDSiCCDS32918.1.
PIRiJE0288.
RefSeqiNP_005806.2. NM_005815.4.
UniGeneiHs.636894.
Hs.720755.

3D structure databases

ProteinModelPortaliQ9Y2A4.
SMRiQ9Y2A4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115518. 1 interactor.
IntActiQ9Y2A4. 1 interactor.
STRINGi9606.ENSP00000301547.

PTM databases

iPTMnetiQ9Y2A4.
PhosphoSitePlusiQ9Y2A4.

Polymorphism and mutation databases

BioMutaiZNF443.
DMDMi296453041.

Proteomic databases

EPDiQ9Y2A4.
MaxQBiQ9Y2A4.
PaxDbiQ9Y2A4.
PeptideAtlasiQ9Y2A4.
PRIDEiQ9Y2A4.

Protocols and materials databases

DNASUi10224.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301547; ENSP00000301547; ENSG00000180855.
GeneIDi10224.
KEGGihsa:10224.
UCSCiuc002mtu.4. human.

Organism-specific databases

CTDi10224.
DisGeNETi10224.
GeneCardsiZNF443.
HGNCiHGNC:20878. ZNF443.
HPAiHPA003150.
HPA018683.
MIMi606697. gene.
neXtProtiNX_Q9Y2A4.
OpenTargetsiENSG00000180855.
PharmGKBiPA134968382.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOVERGENiHBG018163.
InParanoidiQ9Y2A4.
KOiK09228.
OMAiDSSSCLI.
OrthoDBiEOG091G02KC.
PhylomeDBiQ9Y2A4.
TreeFamiTF343410.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000123162-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii10224.
PROiQ9Y2A4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000180855.
CleanExiHS_ZNF443.
ExpressionAtlasiQ9Y2A4. baseline and differential.
GenevisibleiQ9Y2A4. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 19 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 4 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 19 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 16 hits.
PS50157. ZINC_FINGER_C2H2_2. 18 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN443_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2A4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.