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Q9Y296 (TPPC4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Trafficking protein particle complex subunit 4
Alternative name(s):
Hematopoietic stem/progenitor cell protein 172
Synbindin
TRS23 homolog
Gene names
Name:TRAPPC4
Synonyms:SBDN
ORF Names:CGI-104, HSPC172, PTD009
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length219 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in vesicular transport from endoplasmic reticulum to Golgi.

Subunit structure

Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12. Interacts with SDC2 By similarity. Ref.8 Ref.9 Ref.11

Subcellular location

Golgi apparatuscis-Golgi network By similarity. Endoplasmic reticulum By similarity.

Sequence similarities

Belongs to the TRAPP small subunits family. TRAPPC4 subfamily.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Trappc5Q9CQA12EBI-722888,EBI-1172213From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 219219Trafficking protein particle complex subunit 4
PRO_0000211569

Natural variations

Natural variant781D → A.
Corresponds to variant rs11640 [ dbSNP | Ensembl ].
VAR_052397

Secondary structure

..................................... 219
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9Y296 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: C6ADE525B7CFB731

FASTA21924,340
        10         20         30         40         50         60 
MAIFSVYVVN KAGGLIYQLD SYAPRAEAEK TFSYPLDLLL KLHDERVLVA FGQRDGIRVG 

        70         80         90        100        110        120 
HAVLAINGMD VNGRYTADGK EVLEYLGNPA NYPVSIRFGR PRLTSNEKLM LASMFHSLFA 

       130        140        150        160        170        180 
IGSQLSPEQG SSGIEMLETD TFKLHCYQTL TGIKFVVLAD PRQAGIDSLL RKIYEIYSDF 

       190        200        210 
ALKNPFYSLE MPIRCELFDQ NLKLALEVAE KAGTFGPGS 

« Hide

References

« Hide 'large scale' references
[1]"Human unknown mRNA highly conserved among eukaryotes."
Zhu X., Zhao X.
Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]Peng Y., Song H., Dai M., Huang Q., Mao Y., Zhang Q., Mao M., Fu G., Luo M., Chen J., Hu R.
Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pituitary tumor.
[3]"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. expand/collapse author list , Gu J., Chen S.-J., Chen Z.
Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Umbilical cord blood.
[4]"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[8]"Functional organization of the yeast proteome by systematic analysis of protein complexes."
Gavin A.-C., Boesche M., Krause R., Grandi P., Marzioch M., Bauer A., Schultz J., Rick J.M., Michon A.-M., Cruciat C.-M., Remor M., Hoefert C., Schelder M., Brajenovic M., Ruffner H., Merino A., Klein K., Hudak M. expand/collapse author list , Dickson D., Rudi T., Gnau V., Bauch A., Bastuck S., Huhse B., Leutwein C., Heurtier M.-A., Copley R.R., Edelmann A., Querfurth E., Rybin V., Drewes G., Raida M., Bouwmeester T., Bork P., Seraphin B., Kuster B., Neubauer G., Superti-Furga G.
Nature 415:141-147(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN TRAPP COMPLEX.
[9]"TRAPPC2L is a novel, highly conserved TRAPP-interacting protein."
Scrivens P.J., Shahrzad N., Moores A., Morin A., Brunet S., Sacher M.
Traffic 10:724-736(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN TRAPP COMPLEX, INTERACTION WITH TRAPPC2L.
[10]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[11]"C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking."
Scrivens P.J., Noueihed B., Shahrzad N., Hul S., Brunet S., Sacher M.
Mol. Biol. Cell 22:2083-2093(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN TRAPP COMPLEX.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF105025 mRNA. Translation: AAF21897.1.
AF078862 mRNA. Translation: AAD44494.1.
AF161520 mRNA. Translation: AAF29135.1.
AF151862 mRNA. Translation: AAD34099.1.
AK290520 mRNA. Translation: BAF83209.1.
CH471065 Genomic DNA. Translation: EAW67430.1.
BC010866 mRNA. Translation: AAH10866.1.
CCDSCCDS8407.1.
RefSeqNP_057230.1. NM_016146.4.
UniGeneHs.132760.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2J3TX-ray2.40D1-219[»]
2JSNNMR-A19-106[»]
2ZMVX-ray2.80A/B1-219[»]
DisProtDP00562.
ProteinModelPortalQ9Y296.
SMRQ9Y296. Positions 2-215.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119523. 13 interactions.
DIPDIP-37871N.
IntActQ9Y296. 6 interactions.
MINTMINT-1424006.
STRING9606.ENSP00000351896.

PTM databases

PhosphoSiteQ9Y296.

Polymorphism databases

DMDM20178121.

Proteomic databases

MaxQBQ9Y296.
PaxDbQ9Y296.
PRIDEQ9Y296.

Protocols and materials databases

DNASU51399.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000533632; ENSP00000436005; ENSG00000196655.
ENST00000589939; ENSP00000466337; ENSG00000267619.
GeneID51399.
KEGGhsa:51399.
UCSCuc010ryn.2. human.

Organism-specific databases

CTD51399.
GeneCardsGC11P118889.
HGNCHGNC:19943. TRAPPC4.
HPAHPA039752.
HPA041371.
MIM610971. gene.
neXtProtNX_Q9Y296.
PharmGKBPA134906910.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5122.
HOGENOMHOG000165618.
HOVERGENHBG054226.
InParanoidQ9Y296.
OMAGVYIVSK.
PhylomeDBQ9Y296.
TreeFamTF314561.

Enzyme and pathway databases

ReactomeREACT_118779. Extracellular matrix organization.

Gene expression databases

ArrayExpressQ9Y296.
BgeeQ9Y296.
CleanExHS_TRAPPC4.
GenevestigatorQ9Y296.

Family and domain databases

InterProIPR011012. Longin-like_dom.
IPR007233. Sybindin.
[Graphical view]
PANTHERPTHR23249. PTHR23249. 1 hit.
PfamPF04099. Sybindin. 1 hit.
[Graphical view]
SUPFAMSSF64356. SSF64356. 2 hits.
ProtoNetSearch...

Other

ChiTaRSTRAPPC4. human.
EvolutionaryTraceQ9Y296.
GeneWikiTRAPPC4.
GenomeRNAi51399.
NextBio54937.
PROQ9Y296.
SOURCESearch...

Entry information

Entry nameTPPC4_HUMAN
AccessionPrimary (citable) accession number: Q9Y296
Secondary accession number(s): A8K3A5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM