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Protein

Trafficking protein particle complex subunit 4

Gene

TRAPPC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in vesicular transport from endoplasmic reticulum to Golgi.

GO - Molecular functioni

GO - Biological processi

  • COPII vesicle coating Source: Reactome
  • dendrite development Source: UniProtKB
  • ER to Golgi vesicle-mediated transport Source: GO_Central
  • membrane organization Source: Reactome

Keywordsi

Biological processER-Golgi transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-HSA-3000170. Syndecan interactions.
R-HSA-8876198. RAB GEFs exchange GTP for GDP on RABs.

Names & Taxonomyi

Protein namesi
Recommended name:
Trafficking protein particle complex subunit 4
Alternative name(s):
Hematopoietic stem/progenitor cell protein 172
Synbindin
TRS23 homolog
Gene namesi
Name:TRAPPC4
Synonyms:SBDN
ORF Names:CGI-104, HSPC172, PTD009
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000196655.9.
HGNCiHGNC:19943. TRAPPC4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus

Pathology & Biotechi

Organism-specific databases

DisGeNETi51399.
OpenTargetsiENSG00000196655.
PharmGKBiPA134906910.

Chemistry databases

DrugBankiDB08342. S-PALMITOYL-L-CYSTEINE.

Polymorphism and mutation databases

BioMutaiTRAPPC4.
DMDMi20178121.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002115691 – 219Trafficking protein particle complex subunit 4Add BLAST219

Proteomic databases

EPDiQ9Y296.
PaxDbiQ9Y296.
PeptideAtlasiQ9Y296.
PRIDEiQ9Y296.

PTM databases

iPTMnetiQ9Y296.
PhosphoSitePlusiQ9Y296.

Expressioni

Gene expression databases

BgeeiENSG00000196655.
CleanExiHS_TRAPPC4.
ExpressionAtlasiQ9Y296. baseline and differential.
GenevisibleiQ9Y296. HS.

Organism-specific databases

HPAiHPA039752.
HPA041371.

Interactioni

Subunit structurei

Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12. Interacts with SDC2 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Trappc5Q9CQA12EBI-722888,EBI-1172213From Mus musculus.

Protein-protein interaction databases

BioGridi119523. 45 interactors.
CORUMiQ9Y296.
DIPiDIP-37871N.
IntActiQ9Y296. 9 interactors.
MINTiMINT-1424006.
STRINGi9606.ENSP00000436005.

Structurei

Secondary structure

1219
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 9Combined sources7
Beta strandi15 – 20Combined sources6
Beta strandi28 – 32Combined sources5
Beta strandi37 – 42Combined sources6
Beta strandi44 – 51Combined sources8
Beta strandi54 – 56Combined sources3
Turni57 – 60Combined sources4
Beta strandi62 – 66Combined sources5
Beta strandi79 – 81Combined sources3
Helixi82 – 85Combined sources4
Helixi89 – 91Combined sources3
Beta strandi93 – 99Combined sources7
Helixi105 – 124Combined sources20
Beta strandi127 – 130Combined sources4
Beta strandi135 – 141Combined sources7
Beta strandi143 – 148Combined sources6
Beta strandi154 – 159Combined sources6
Helixi166 – 181Combined sources16
Helixi196 – 209Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2J3TX-ray2.40D1-219[»]
2JSNNMR-A19-106[»]
2ZMVX-ray2.80A/B1-219[»]
DisProtiDP00562.
ProteinModelPortaliQ9Y296.
SMRiQ9Y296.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y296.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3369. Eukaryota.
COG5122. LUCA.
GeneTreeiENSGT00510000047061.
HOGENOMiHOG000165618.
HOVERGENiHBG054226.
InParanoidiQ9Y296.
KOiK20303.
OMAiGQRDGIN.
PhylomeDBiQ9Y296.
TreeFamiTF314561.

Family and domain databases

InterProiView protein in InterPro
IPR011012. Longin-like_dom.
IPR007233. TRAPPC.
PANTHERiPTHR23249. PTHR23249. 1 hit.
PfamiView protein in Pfam
PF04099. Sybindin. 1 hit.
SMARTiView protein in SMART
SM01399. Sybindin. 1 hit.
SUPFAMiSSF64356. SSF64356. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y296-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAIFSVYVVN KAGGLIYQLD SYAPRAEAEK TFSYPLDLLL KLHDERVLVA
60 70 80 90 100
FGQRDGIRVG HAVLAINGMD VNGRYTADGK EVLEYLGNPA NYPVSIRFGR
110 120 130 140 150
PRLTSNEKLM LASMFHSLFA IGSQLSPEQG SSGIEMLETD TFKLHCYQTL
160 170 180 190 200
TGIKFVVLAD PRQAGIDSLL RKIYEIYSDF ALKNPFYSLE MPIRCELFDQ
210
NLKLALEVAE KAGTFGPGS
Length:219
Mass (Da):24,340
Last modified:November 1, 1999 - v1
Checksum:iC6ADE525B7CFB731
GO
Isoform 2 (identifier: Q9Y296-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     81-134: Missing.

Note: No experimental confirmation available.
Show »
Length:165
Mass (Da):18,446
Checksum:i9ED57477C1259464
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05239778D → A. Corresponds to variant dbSNP:rs11640Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05634881 – 134Missing in isoform 2. 1 PublicationAdd BLAST54

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF105025 mRNA. Translation: AAF21897.1.
AF078862 mRNA. Translation: AAD44494.1.
AF161520 mRNA. Translation: AAF29135.1.
AF151862 mRNA. Translation: AAD34099.1.
AK290520 mRNA. Translation: BAF83209.1.
AK297422 mRNA. Translation: BAG59853.1.
AP003392 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW67430.1.
BC010866 mRNA. Translation: AAH10866.1.
CCDSiCCDS81633.1. [Q9Y296-2]
CCDS8407.1. [Q9Y296-1]
RefSeqiNP_001305415.1. NM_001318486.1.
NP_001305417.1. NM_001318488.1.
NP_001305418.1. NM_001318489.1. [Q9Y296-2]
NP_001305419.1. NM_001318490.1.
NP_001305421.1. NM_001318492.1.
NP_001305423.1. NM_001318494.1.
NP_057230.1. NM_016146.5. [Q9Y296-1]
UniGeneiHs.132760.

Genome annotation databases

EnsembliENST00000434101; ENSP00000405033; ENSG00000196655. [Q9Y296-2]
ENST00000533632; ENSP00000436005; ENSG00000196655. [Q9Y296-1]
ENST00000629243; ENSP00000487467; ENSG00000280495. [Q9Y296-1]
ENST00000629713; ENSP00000486496; ENSG00000280495. [Q9Y296-2]
GeneIDi51399.
KEGGihsa:51399.
UCSCiuc010ryo.4. human. [Q9Y296-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTPPC4_HUMAN
AccessioniPrimary (citable) accession number: Q9Y296
Secondary accession number(s): A8K3A5, B4DME1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: November 1, 1999
Last modified: October 25, 2017
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families