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Q9Y296

- TPPC4_HUMAN

UniProt

Q9Y296 - TPPC4_HUMAN

Protein

Trafficking protein particle complex subunit 4

Gene

TRAPPC4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    May play a role in vesicular transport from endoplasmic reticulum to Golgi.

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. dendrite development Source: UniProtKB
    2. ER to Golgi vesicle-mediated transport Source: InterPro
    3. extracellular matrix organization Source: Reactome

    Keywords - Biological processi

    ER-Golgi transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_163942. Syndecan interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Trafficking protein particle complex subunit 4
    Alternative name(s):
    Hematopoietic stem/progenitor cell protein 172
    Synbindin
    TRS23 homolog
    Gene namesi
    Name:TRAPPC4
    Synonyms:SBDN
    ORF Names:CGI-104, HSPC172, PTD009
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:19943. TRAPPC4.

    Subcellular locationi

    GO - Cellular componenti

    1. cis-Golgi network Source: InterPro
    2. dendrite Source: UniProtKB
    3. endoplasmic reticulum Source: UniProtKB-SubCell
    4. Golgi stack Source: UniProtKB
    5. synapse Source: UniProtKB
    6. synaptic vesicle Source: UniProtKB
    7. TRAPP complex Source: Ensembl

    Keywords - Cellular componenti

    Endoplasmic reticulum, Golgi apparatus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134906910.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 219219Trafficking protein particle complex subunit 4PRO_0000211569Add
    BLAST

    Proteomic databases

    MaxQBiQ9Y296.
    PaxDbiQ9Y296.
    PRIDEiQ9Y296.

    PTM databases

    PhosphoSiteiQ9Y296.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Y296.
    BgeeiQ9Y296.
    CleanExiHS_TRAPPC4.
    GenevestigatoriQ9Y296.

    Organism-specific databases

    HPAiHPA039752.
    HPA041371.

    Interactioni

    Subunit structurei

    Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12. Interacts with SDC2 By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Trappc5Q9CQA12EBI-722888,EBI-1172213From a different organism.

    Protein-protein interaction databases

    BioGridi119523. 13 interactions.
    DIPiDIP-37871N.
    IntActiQ9Y296. 6 interactions.
    MINTiMINT-1424006.
    STRINGi9606.ENSP00000351896.

    Structurei

    Secondary structure

    1
    219
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi3 – 97
    Beta strandi15 – 206
    Beta strandi28 – 325
    Beta strandi37 – 426
    Beta strandi44 – 518
    Beta strandi54 – 563
    Turni57 – 604
    Beta strandi62 – 665
    Beta strandi79 – 813
    Helixi82 – 854
    Helixi89 – 913
    Beta strandi93 – 997
    Helixi105 – 12420
    Beta strandi127 – 1304
    Beta strandi135 – 1417
    Beta strandi143 – 1486
    Beta strandi154 – 1596
    Helixi166 – 18116
    Helixi196 – 20914

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2J3TX-ray2.40D1-219[»]
    2JSNNMR-A19-106[»]
    2ZMVX-ray2.80A/B1-219[»]
    DisProtiDP00562.
    ProteinModelPortaliQ9Y296.
    SMRiQ9Y296. Positions 2-215.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9Y296.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG5122.
    HOGENOMiHOG000165618.
    HOVERGENiHBG054226.
    InParanoidiQ9Y296.
    OMAiGVYIVSK.
    PhylomeDBiQ9Y296.
    TreeFamiTF314561.

    Family and domain databases

    InterProiIPR011012. Longin-like_dom.
    IPR007233. Sybindin.
    [Graphical view]
    PANTHERiPTHR23249. PTHR23249. 1 hit.
    PfamiPF04099. Sybindin. 1 hit.
    [Graphical view]
    SUPFAMiSSF64356. SSF64356. 2 hits.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y296-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAIFSVYVVN KAGGLIYQLD SYAPRAEAEK TFSYPLDLLL KLHDERVLVA    50
    FGQRDGIRVG HAVLAINGMD VNGRYTADGK EVLEYLGNPA NYPVSIRFGR 100
    PRLTSNEKLM LASMFHSLFA IGSQLSPEQG SSGIEMLETD TFKLHCYQTL 150
    TGIKFVVLAD PRQAGIDSLL RKIYEIYSDF ALKNPFYSLE MPIRCELFDQ 200
    NLKLALEVAE KAGTFGPGS 219
    Length:219
    Mass (Da):24,340
    Last modified:November 1, 1999 - v1
    Checksum:iC6ADE525B7CFB731
    GO
    Isoform 2 (identifier: Q9Y296-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         81-134: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:165
    Mass (Da):18,446
    Checksum:i9ED57477C1259464
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti78 – 781D → A.
    Corresponds to variant rs11640 [ dbSNP | Ensembl ].
    VAR_052397

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei81 – 13454Missing in isoform 2. 1 PublicationVSP_056348Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF105025 mRNA. Translation: AAF21897.1.
    AF078862 mRNA. Translation: AAD44494.1.
    AF161520 mRNA. Translation: AAF29135.1.
    AF151862 mRNA. Translation: AAD34099.1.
    AK290520 mRNA. Translation: BAF83209.1.
    AK297422 mRNA. Translation: BAG59853.1.
    AP003392 Genomic DNA. No translation available.
    CH471065 Genomic DNA. Translation: EAW67430.1.
    BC010866 mRNA. Translation: AAH10866.1.
    CCDSiCCDS8407.1.
    RefSeqiNP_057230.1. NM_016146.4.
    UniGeneiHs.132760.

    Genome annotation databases

    EnsembliENST00000434101; ENSP00000405033; ENSG00000196655.
    ENST00000533632; ENSP00000436005; ENSG00000196655.
    GeneIDi51399.
    KEGGihsa:51399.
    UCSCiuc010ryn.2. human.

    Polymorphism databases

    DMDMi20178121.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF105025 mRNA. Translation: AAF21897.1 .
    AF078862 mRNA. Translation: AAD44494.1 .
    AF161520 mRNA. Translation: AAF29135.1 .
    AF151862 mRNA. Translation: AAD34099.1 .
    AK290520 mRNA. Translation: BAF83209.1 .
    AK297422 mRNA. Translation: BAG59853.1 .
    AP003392 Genomic DNA. No translation available.
    CH471065 Genomic DNA. Translation: EAW67430.1 .
    BC010866 mRNA. Translation: AAH10866.1 .
    CCDSi CCDS8407.1.
    RefSeqi NP_057230.1. NM_016146.4.
    UniGenei Hs.132760.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2J3T X-ray 2.40 D 1-219 [» ]
    2JSN NMR - A 19-106 [» ]
    2ZMV X-ray 2.80 A/B 1-219 [» ]
    DisProti DP00562.
    ProteinModelPortali Q9Y296.
    SMRi Q9Y296. Positions 2-215.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119523. 13 interactions.
    DIPi DIP-37871N.
    IntActi Q9Y296. 6 interactions.
    MINTi MINT-1424006.
    STRINGi 9606.ENSP00000351896.

    PTM databases

    PhosphoSitei Q9Y296.

    Polymorphism databases

    DMDMi 20178121.

    Proteomic databases

    MaxQBi Q9Y296.
    PaxDbi Q9Y296.
    PRIDEi Q9Y296.

    Protocols and materials databases

    DNASUi 51399.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000434101 ; ENSP00000405033 ; ENSG00000196655 .
    ENST00000533632 ; ENSP00000436005 ; ENSG00000196655 .
    GeneIDi 51399.
    KEGGi hsa:51399.
    UCSCi uc010ryn.2. human.

    Organism-specific databases

    CTDi 51399.
    GeneCardsi GC11P118889.
    HGNCi HGNC:19943. TRAPPC4.
    HPAi HPA039752.
    HPA041371.
    MIMi 610971. gene.
    neXtProti NX_Q9Y296.
    PharmGKBi PA134906910.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5122.
    HOGENOMi HOG000165618.
    HOVERGENi HBG054226.
    InParanoidi Q9Y296.
    OMAi GVYIVSK.
    PhylomeDBi Q9Y296.
    TreeFami TF314561.

    Enzyme and pathway databases

    Reactomei REACT_163942. Syndecan interactions.

    Miscellaneous databases

    ChiTaRSi TRAPPC4. human.
    EvolutionaryTracei Q9Y296.
    GeneWikii TRAPPC4.
    GenomeRNAii 51399.
    NextBioi 54937.
    PROi Q9Y296.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y296.
    Bgeei Q9Y296.
    CleanExi HS_TRAPPC4.
    Genevestigatori Q9Y296.

    Family and domain databases

    InterProi IPR011012. Longin-like_dom.
    IPR007233. Sybindin.
    [Graphical view ]
    PANTHERi PTHR23249. PTHR23249. 1 hit.
    Pfami PF04099. Sybindin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF64356. SSF64356. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Human unknown mRNA highly conserved among eukaryotes."
      Zhu X., Zhao X.
      Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. Peng Y., Song H., Dai M., Huang Q., Mao Y., Zhang Q., Mao M., Fu G., Luo M., Chen J., Hu R.
      Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Pituitary tumor.
    3. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
      Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
      , Gu J., Chen S.-J., Chen Z.
      Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Umbilical cord blood.
    4. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
      Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
      Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung.
    9. Cited for: IDENTIFICATION IN TRAPP COMPLEX.
    10. "TRAPPC2L is a novel, highly conserved TRAPP-interacting protein."
      Scrivens P.J., Shahrzad N., Moores A., Morin A., Brunet S., Sacher M.
      Traffic 10:724-736(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN TRAPP COMPLEX, INTERACTION WITH TRAPPC2L.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking."
      Scrivens P.J., Noueihed B., Shahrzad N., Hul S., Brunet S., Sacher M.
      Mol. Biol. Cell 22:2083-2093(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN TRAPP COMPLEX.

    Entry informationi

    Entry nameiTPPC4_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y296
    Secondary accession number(s): A8K3A5, B4DME1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 16, 2002
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3