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Q9Y296

- TPPC4_HUMAN

UniProt

Q9Y296 - TPPC4_HUMAN

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Protein

Trafficking protein particle complex subunit 4

Gene

TRAPPC4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May play a role in vesicular transport from endoplasmic reticulum to Golgi.

GO - Biological processi

  1. dendrite development Source: UniProtKB
  2. ER to Golgi vesicle-mediated transport Source: InterPro
  3. extracellular matrix organization Source: Reactome
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Transport

Enzyme and pathway databases

ReactomeiREACT_163942. Syndecan interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Trafficking protein particle complex subunit 4
Alternative name(s):
Hematopoietic stem/progenitor cell protein 172
Synbindin
TRS23 homolog
Gene namesi
Name:TRAPPC4
Synonyms:SBDN
ORF Names:CGI-104, HSPC172, PTD009
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:19943. TRAPPC4.

Subcellular locationi

GO - Cellular componenti

  1. cis-Golgi network Source: InterPro
  2. dendrite Source: UniProtKB
  3. endoplasmic reticulum Source: UniProtKB-KW
  4. Golgi stack Source: UniProtKB
  5. synapse Source: UniProtKB
  6. synaptic vesicle Source: UniProtKB
  7. TRAPP complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134906910.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 219219Trafficking protein particle complex subunit 4PRO_0000211569Add
BLAST

Proteomic databases

MaxQBiQ9Y296.
PaxDbiQ9Y296.
PRIDEiQ9Y296.

PTM databases

PhosphoSiteiQ9Y296.

Expressioni

Gene expression databases

BgeeiQ9Y296.
CleanExiHS_TRAPPC4.
ExpressionAtlasiQ9Y296. baseline and differential.
GenevestigatoriQ9Y296.

Organism-specific databases

HPAiHPA039752.
HPA041371.

Interactioni

Subunit structurei

Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12. Interacts with SDC2 By similarity.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Trappc5Q9CQA12EBI-722888,EBI-1172213From a different organism.

Protein-protein interaction databases

BioGridi119523. 15 interactions.
DIPiDIP-37871N.
IntActiQ9Y296. 6 interactions.
MINTiMINT-1424006.
STRINGi9606.ENSP00000351896.

Structurei

Secondary structure

1
219
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 97
Beta strandi15 – 206
Beta strandi28 – 325
Beta strandi37 – 426
Beta strandi44 – 518
Beta strandi54 – 563
Turni57 – 604
Beta strandi62 – 665
Beta strandi79 – 813
Helixi82 – 854
Helixi89 – 913
Beta strandi93 – 997
Helixi105 – 12420
Beta strandi127 – 1304
Beta strandi135 – 1417
Beta strandi143 – 1486
Beta strandi154 – 1596
Helixi166 – 18116
Helixi196 – 20914

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2J3TX-ray2.40D1-219[»]
2JSNNMR-A19-106[»]
2ZMVX-ray2.80A/B1-219[»]
DisProtiDP00562.
ProteinModelPortaliQ9Y296.
SMRiQ9Y296. Positions 2-215.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y296.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5122.
GeneTreeiENSGT00510000047061.
HOGENOMiHOG000165618.
HOVERGENiHBG054226.
InParanoidiQ9Y296.
OMAiGVYIVSK.
PhylomeDBiQ9Y296.
TreeFamiTF314561.

Family and domain databases

InterProiIPR011012. Longin-like_dom.
IPR007233. Sybindin.
[Graphical view]
PANTHERiPTHR23249. PTHR23249. 1 hit.
PfamiPF04099. Sybindin. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9Y296-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAIFSVYVVN KAGGLIYQLD SYAPRAEAEK TFSYPLDLLL KLHDERVLVA
60 70 80 90 100
FGQRDGIRVG HAVLAINGMD VNGRYTADGK EVLEYLGNPA NYPVSIRFGR
110 120 130 140 150
PRLTSNEKLM LASMFHSLFA IGSQLSPEQG SSGIEMLETD TFKLHCYQTL
160 170 180 190 200
TGIKFVVLAD PRQAGIDSLL RKIYEIYSDF ALKNPFYSLE MPIRCELFDQ
210
NLKLALEVAE KAGTFGPGS
Length:219
Mass (Da):24,340
Last modified:November 1, 1999 - v1
Checksum:iC6ADE525B7CFB731
GO
Isoform 2 (identifier: Q9Y296-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     81-134: Missing.

Note: No experimental confirmation available.

Show »
Length:165
Mass (Da):18,446
Checksum:i9ED57477C1259464
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti78 – 781D → A.
Corresponds to variant rs11640 [ dbSNP | Ensembl ].
VAR_052397

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei81 – 13454Missing in isoform 2. 1 PublicationVSP_056348Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF105025 mRNA. Translation: AAF21897.1.
AF078862 mRNA. Translation: AAD44494.1.
AF161520 mRNA. Translation: AAF29135.1.
AF151862 mRNA. Translation: AAD34099.1.
AK290520 mRNA. Translation: BAF83209.1.
AK297422 mRNA. Translation: BAG59853.1.
AP003392 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW67430.1.
BC010866 mRNA. Translation: AAH10866.1.
CCDSiCCDS8407.1. [Q9Y296-1]
RefSeqiNP_057230.1. NM_016146.4.
UniGeneiHs.132760.

Genome annotation databases

EnsembliENST00000434101; ENSP00000405033; ENSG00000196655. [Q9Y296-2]
ENST00000533632; ENSP00000436005; ENSG00000196655. [Q9Y296-1]
GeneIDi51399.
KEGGihsa:51399.
UCSCiuc010ryn.2. human. [Q9Y296-1]

Polymorphism databases

DMDMi20178121.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF105025 mRNA. Translation: AAF21897.1 .
AF078862 mRNA. Translation: AAD44494.1 .
AF161520 mRNA. Translation: AAF29135.1 .
AF151862 mRNA. Translation: AAD34099.1 .
AK290520 mRNA. Translation: BAF83209.1 .
AK297422 mRNA. Translation: BAG59853.1 .
AP003392 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW67430.1 .
BC010866 mRNA. Translation: AAH10866.1 .
CCDSi CCDS8407.1. [Q9Y296-1 ]
RefSeqi NP_057230.1. NM_016146.4.
UniGenei Hs.132760.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2J3T X-ray 2.40 D 1-219 [» ]
2JSN NMR - A 19-106 [» ]
2ZMV X-ray 2.80 A/B 1-219 [» ]
DisProti DP00562.
ProteinModelPortali Q9Y296.
SMRi Q9Y296. Positions 2-215.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119523. 15 interactions.
DIPi DIP-37871N.
IntActi Q9Y296. 6 interactions.
MINTi MINT-1424006.
STRINGi 9606.ENSP00000351896.

PTM databases

PhosphoSitei Q9Y296.

Polymorphism databases

DMDMi 20178121.

Proteomic databases

MaxQBi Q9Y296.
PaxDbi Q9Y296.
PRIDEi Q9Y296.

Protocols and materials databases

DNASUi 51399.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000434101 ; ENSP00000405033 ; ENSG00000196655 . [Q9Y296-2 ]
ENST00000533632 ; ENSP00000436005 ; ENSG00000196655 . [Q9Y296-1 ]
GeneIDi 51399.
KEGGi hsa:51399.
UCSCi uc010ryn.2. human. [Q9Y296-1 ]

Organism-specific databases

CTDi 51399.
GeneCardsi GC11P118889.
HGNCi HGNC:19943. TRAPPC4.
HPAi HPA039752.
HPA041371.
MIMi 610971. gene.
neXtProti NX_Q9Y296.
PharmGKBi PA134906910.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5122.
GeneTreei ENSGT00510000047061.
HOGENOMi HOG000165618.
HOVERGENi HBG054226.
InParanoidi Q9Y296.
OMAi GVYIVSK.
PhylomeDBi Q9Y296.
TreeFami TF314561.

Enzyme and pathway databases

Reactomei REACT_163942. Syndecan interactions.

Miscellaneous databases

ChiTaRSi TRAPPC4. human.
EvolutionaryTracei Q9Y296.
GeneWikii TRAPPC4.
GenomeRNAii 51399.
NextBioi 35473298.
PROi Q9Y296.
SOURCEi Search...

Gene expression databases

Bgeei Q9Y296.
CleanExi HS_TRAPPC4.
ExpressionAtlasi Q9Y296. baseline and differential.
Genevestigatori Q9Y296.

Family and domain databases

InterProi IPR011012. Longin-like_dom.
IPR007233. Sybindin.
[Graphical view ]
PANTHERi PTHR23249. PTHR23249. 1 hit.
Pfami PF04099. Sybindin. 1 hit.
[Graphical view ]
SUPFAMi SSF64356. SSF64356. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human unknown mRNA highly conserved among eukaryotes."
    Zhu X., Zhao X.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. Peng Y., Song H., Dai M., Huang Q., Mao Y., Zhang Q., Mao M., Fu G., Luo M., Chen J., Hu R.
    Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Pituitary tumor.
  3. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Umbilical cord blood.
  4. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
    Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
    Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung.
  9. Cited for: IDENTIFICATION IN TRAPP COMPLEX.
  10. "TRAPPC2L is a novel, highly conserved TRAPP-interacting protein."
    Scrivens P.J., Shahrzad N., Moores A., Morin A., Brunet S., Sacher M.
    Traffic 10:724-736(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN TRAPP COMPLEX, INTERACTION WITH TRAPPC2L.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking."
    Scrivens P.J., Noueihed B., Shahrzad N., Hul S., Brunet S., Sacher M.
    Mol. Biol. Cell 22:2083-2093(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN TRAPP COMPLEX.

Entry informationi

Entry nameiTPPC4_HUMAN
AccessioniPrimary (citable) accession number: Q9Y296
Secondary accession number(s): A8K3A5, B4DME1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: November 1, 1999
Last modified: October 29, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3