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Protein

Developmentally-regulated GTP-binding protein 1

Gene

DRG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Critical regulator of cell growth under specific conditions. Implicated in differentiation and cell cycle arrest.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi71 – 78GTPPROSITE-ProRule annotation8
Nucleotide bindingi117 – 121GTPPROSITE-ProRule annotation5
Nucleotide bindingi248 – 251GTPPROSITE-ProRule annotation4

GO - Molecular functioni

  • GTP binding Source: UniProtKB-KW
  • transcription factor binding Source: ProtInc

GO - Biological processi

  • multicellular organism development Source: ProtInc
  • transcription, DNA-templated Source: ProtInc
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Developmentally-regulated GTP-binding protein 1
Short name:
DRG-1
Alternative name(s):
Neural precursor cell expressed developmentally down-regulated protein 3
Short name:
NEDD-3
Gene namesi
Name:DRG1
Synonyms:NEDD3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:3029. DRG1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • membrane Source: UniProtKB
  • polysome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi4733.
OpenTargetsiENSG00000185721.
PharmGKBiPA27483.

Polymorphism and mutation databases

BioMutaiDRG1.
DMDMi6685390.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002054242 – 367Developmentally-regulated GTP-binding protein 1Add BLAST366

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei100Phosphothreonine; by STK161 Publication1

Post-translational modificationi

Sumoylated by UBE2I in response to MEKK1-mediated stimuli.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9Y295.
MaxQBiQ9Y295.
PaxDbiQ9Y295.
PeptideAtlasiQ9Y295.
PRIDEiQ9Y295.

PTM databases

iPTMnetiQ9Y295.
PhosphoSitePlusiQ9Y295.
SwissPalmiQ9Y295.

Expressioni

Tissue specificityi

High levels in skeletal muscle, heart, and kidney. Intermediate levels in liver, placenta and brain. Low levels in colon, thymus, spleen, small intestine, lung and leukocytes.1 Publication

Inductioni

By androgens.

Gene expression databases

BgeeiENSG00000185721.
CleanExiHS_DRG1.
ExpressionAtlasiQ9Y295. baseline and differential.
GenevisibleiQ9Y295. HS.

Organism-specific databases

HPAiHPA001218.

Interactioni

Subunit structurei

Interacts (via its C-terminal) with TAL1. Interacts with ZC3H15; the interaction forms a polysomal DRG1-DFRP1/ZC3H15 complex which provides protein stability to DRG1 possibly by blocking poly-ubiquitination. Interacts with STK16; the interaction phosphorylates STK16 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-719554,EBI-719554
COILP384323EBI-719554,EBI-945751
MQ9WH763EBI-719554,EBI-10823897From a different organism.
PHC2Q8IXK04EBI-719554,EBI-713786
RWDD1Q9H4467EBI-719554,EBI-748952
SKILP127573EBI-719554,EBI-2902468
SSX2IPQ9Y2D83EBI-719554,EBI-2212028
STK16O757163EBI-719554,EBI-749295
ZC3H15Q8WU907EBI-719554,EBI-1042636

GO - Molecular functioni

  • transcription factor binding Source: ProtInc

Protein-protein interaction databases

BioGridi110810. 46 interactors.
IntActiQ9Y295. 29 interactors.
MINTiMINT-5006718.
STRINGi9606.ENSP00000329715.

Structurei

Secondary structure

1367
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi291 – 296Combined sources6
Beta strandi305 – 307Combined sources3
Beta strandi309 – 312Combined sources4
Helixi318 – 325Combined sources8
Turni330 – 332Combined sources3
Beta strandi333 – 340Combined sources8
Beta strandi343 – 350Combined sources8
Beta strandi358 – 362Combined sources5
Beta strandi364 – 366Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EKINMR-A288-367[»]
ProteinModelPortaliQ9Y295.
SMRiQ9Y295.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y295.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini65 – 290OBG-type GPROSITE-ProRule annotationAdd BLAST226

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 16Required for interaction with STK16Add BLAST15

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi47 – 56Poly-Gly10

Sequence similaritiesi

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.PROSITE-ProRule annotation
Contains 1 OBG-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1487. Eukaryota.
COG1163. LUCA.
GeneTreeiENSGT00550000075013.
HOGENOMiHOG000112078.
HOVERGENiHBG000948.
InParanoidiQ9Y295.
OMAiIENEMAR.
OrthoDBiEOG091G0A12.
PhylomeDBiQ9Y295.
TreeFamiTF105677.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR012675. Beta-grasp_dom.
IPR031167. G_OBG.
IPR031662. GTP-binding_2.
IPR006074. GTP1-OBG_CS.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view]
PfamiPF01926. MMR_HSR1. 1 hit.
PF16897. MMR_HSR1_Xtn. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view]
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF81271. SSF81271. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51710. G_OBG. 1 hit.
PS00905. GTP1_OBG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y295-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSTLAKIAE IEAEMARTQK NKATAHHLGL LKARLAKLRR ELITPKGGGG
60 70 80 90 100
GGPGEGFDVA KTGDARIGFV GFPSVGKSTL LSNLAGVYSE VAAYEFTTLT
110 120 130 140 150
TVPGVIRYKG AKIQLLDLPG IIEGAKDGKG RGRQVIAVAR TCNLILIVLD
160 170 180 190 200
VLKPLGHKKI IENELEGFGI RLNSKPPNIG FKKKDKGGIN LTATCPQSEL
210 220 230 240 250
DAETVKSILA EYKIHNADVT LRSDATADDL IDVVEGNRVY IPCIYVLNKI
260 270 280 290 300
DQISIEELDI IYKVPHCVPI SAHHRWNFDD LLEKIWDYLK LVRIYTKPKG
310 320 330 340 350
QLPDYTSPVV LPYSRTTVED FCMKIHKNLI KEFKYALVWG LSVKHNPQKV
360
GKDHTLEDED VIQIVKK
Length:367
Mass (Da):40,542
Last modified:November 1, 1999 - v1
Checksum:i4A177EA7C8E23005
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti91V → A in AAH20803 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF078103 mRNA. Translation: AAD12240.1.
AJ005940 mRNA. Translation: CAA06775.1.
CR542059 mRNA. Translation: CAG46856.1.
CR456488 mRNA. Translation: CAG30374.1.
BT007237 mRNA. Translation: AAP35901.1.
AK315659 mRNA. Translation: BAG38025.1.
AL096701, AL096702 Genomic DNA. Translation: CAI12876.1.
AL096702, AL096701 Genomic DNA. Translation: CAH71744.1.
CH471095 Genomic DNA. Translation: EAW59976.1.
BC019285 mRNA. Translation: AAH19285.1.
BC020803 mRNA. Translation: AAH20803.1.
CCDSiCCDS13897.1.
RefSeqiNP_004138.1. NM_004147.3.
UniGeneiHs.115242.

Genome annotation databases

EnsembliENST00000331457; ENSP00000329715; ENSG00000185721.
GeneIDi4733.
KEGGihsa:4733.
UCSCiuc003aku.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF078103 mRNA. Translation: AAD12240.1.
AJ005940 mRNA. Translation: CAA06775.1.
CR542059 mRNA. Translation: CAG46856.1.
CR456488 mRNA. Translation: CAG30374.1.
BT007237 mRNA. Translation: AAP35901.1.
AK315659 mRNA. Translation: BAG38025.1.
AL096701, AL096702 Genomic DNA. Translation: CAI12876.1.
AL096702, AL096701 Genomic DNA. Translation: CAH71744.1.
CH471095 Genomic DNA. Translation: EAW59976.1.
BC019285 mRNA. Translation: AAH19285.1.
BC020803 mRNA. Translation: AAH20803.1.
CCDSiCCDS13897.1.
RefSeqiNP_004138.1. NM_004147.3.
UniGeneiHs.115242.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EKINMR-A288-367[»]
ProteinModelPortaliQ9Y295.
SMRiQ9Y295.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110810. 46 interactors.
IntActiQ9Y295. 29 interactors.
MINTiMINT-5006718.
STRINGi9606.ENSP00000329715.

PTM databases

iPTMnetiQ9Y295.
PhosphoSitePlusiQ9Y295.
SwissPalmiQ9Y295.

Polymorphism and mutation databases

BioMutaiDRG1.
DMDMi6685390.

Proteomic databases

EPDiQ9Y295.
MaxQBiQ9Y295.
PaxDbiQ9Y295.
PeptideAtlasiQ9Y295.
PRIDEiQ9Y295.

Protocols and materials databases

DNASUi4733.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331457; ENSP00000329715; ENSG00000185721.
GeneIDi4733.
KEGGihsa:4733.
UCSCiuc003aku.4. human.

Organism-specific databases

CTDi4733.
DisGeNETi4733.
GeneCardsiDRG1.
HGNCiHGNC:3029. DRG1.
HPAiHPA001218.
MIMi603952. gene.
neXtProtiNX_Q9Y295.
OpenTargetsiENSG00000185721.
PharmGKBiPA27483.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1487. Eukaryota.
COG1163. LUCA.
GeneTreeiENSGT00550000075013.
HOGENOMiHOG000112078.
HOVERGENiHBG000948.
InParanoidiQ9Y295.
OMAiIENEMAR.
OrthoDBiEOG091G0A12.
PhylomeDBiQ9Y295.
TreeFamiTF105677.

Miscellaneous databases

ChiTaRSiDRG1. human.
EvolutionaryTraceiQ9Y295.
GeneWikiiDRG1.
GenomeRNAii4733.
PROiQ9Y295.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000185721.
CleanExiHS_DRG1.
ExpressionAtlasiQ9Y295. baseline and differential.
GenevisibleiQ9Y295. HS.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR012675. Beta-grasp_dom.
IPR031167. G_OBG.
IPR031662. GTP-binding_2.
IPR006074. GTP1-OBG_CS.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view]
PfamiPF01926. MMR_HSR1. 1 hit.
PF16897. MMR_HSR1_Xtn. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view]
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF81271. SSF81271. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51710. G_OBG. 1 hit.
PS00905. GTP1_OBG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDRG1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y295
Secondary accession number(s): B2RDS8
, Q6FGP8, Q8WW69, Q9UGF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: November 30, 2016
This is version 158 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.