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Protein

28S ribosomal protein S33, mitochondrial

Gene

MRPS33

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S33, mitochondrial
Short name:
MRP-S33
Short name:
S33mt
Alternative name(s):
Mitochondrial small ribosomal subunit protein mS331 Publication
Gene namesi
Name:MRPS33
ORF Names:CGI-139, PTD003
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:16634. MRPS33.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial inner membrane Source: Reactome
  • mitochondrial small ribosomal subunit Source: UniProtKB
  • mitochondrion Source: GO_Central

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi51650.
OpenTargetsiENSG00000090263.
PharmGKBiPA31020.

Polymorphism and mutation databases

BioMutaiMRPS33.
DMDMi24212388.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000877272 – 10628S ribosomal protein S33, mitochondrialAdd BLAST105

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9Y291.
MaxQBiQ9Y291.
PaxDbiQ9Y291.
PeptideAtlasiQ9Y291.
PRIDEiQ9Y291.
TopDownProteomicsiQ9Y291.

PTM databases

iPTMnetiQ9Y291.
PhosphoSitePlusiQ9Y291.

Expressioni

Gene expression databases

BgeeiENSG00000090263.
CleanExiHS_MRPS33.
ExpressionAtlasiQ9Y291. baseline and differential.
GenevisibleiQ9Y291. HS.

Organism-specific databases

HPAiHPA030425.

Interactioni

Subunit structurei

Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.1 Publication

Protein-protein interaction databases

BioGridi119658. 26 interactors.
IntActiQ9Y291. 5 interactors.
STRINGi9606.ENSP00000320567.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AZ1-106[»]
ProteinModelPortaliQ9Y291.
SMRiQ9Y291.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4104. Eukaryota.
ENOG4111X83. LUCA.
GeneTreeiENSGT00390000011401.
HOVERGENiHBG036129.
InParanoidiQ9Y291.
KOiK17411.
OMAiKEVYDWY.
OrthoDBiEOG091G0Y05.
PhylomeDBiQ9Y291.
TreeFamiTF313928.

Family and domain databases

InterProiView protein in InterPro
IPR013219. Ribosomal_S27/S33_mit.
PANTHERiPTHR13362. PTHR13362. 1 hit.
PfamiView protein in Pfam
PF08293. MRP-S33. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y291-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSLSEYAFR MSRLSARLFG EVTRPTNSKS MKVVKLFSEL PLAKKKETYD
60 70 80 90 100
WYPNHHTYAE LMQTLRFLGL YRDEHQDFMD EQKRLKKLRG KEKPKKGEGK

RAAKRK
Length:106
Mass (Da):12,629
Last modified:November 1, 1999 - v1
Checksum:iE755EDAFB6AF6A46
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151897 mRNA. Translation: AAD34134.1.
AF078858 mRNA. Translation: AAD44490.1.
AC006006 Genomic DNA. Translation: AAD43190.1.
BC015462 mRNA. Translation: AAH15462.1.
CCDSiCCDS5864.1.
RefSeqiNP_057155.1. NM_016071.3.
NP_444263.1. NM_053035.2.
UniGeneiHs.416207.

Genome annotation databases

EnsembliENST00000324787; ENSP00000320567; ENSG00000090263.
ENST00000393008; ENSP00000376732; ENSG00000090263.
ENST00000469351; ENSP00000417287; ENSG00000090263.
ENST00000496958; ENSP00000418451; ENSG00000090263.
GeneIDi51650.
KEGGihsa:51650.
UCSCiuc003vwd.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151897 mRNA. Translation: AAD34134.1.
AF078858 mRNA. Translation: AAD44490.1.
AC006006 Genomic DNA. Translation: AAD43190.1.
BC015462 mRNA. Translation: AAH15462.1.
CCDSiCCDS5864.1.
RefSeqiNP_057155.1. NM_016071.3.
NP_444263.1. NM_053035.2.
UniGeneiHs.416207.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AZ1-106[»]
ProteinModelPortaliQ9Y291.
SMRiQ9Y291.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119658. 26 interactors.
IntActiQ9Y291. 5 interactors.
STRINGi9606.ENSP00000320567.

PTM databases

iPTMnetiQ9Y291.
PhosphoSitePlusiQ9Y291.

Polymorphism and mutation databases

BioMutaiMRPS33.
DMDMi24212388.

Proteomic databases

EPDiQ9Y291.
MaxQBiQ9Y291.
PaxDbiQ9Y291.
PeptideAtlasiQ9Y291.
PRIDEiQ9Y291.
TopDownProteomicsiQ9Y291.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324787; ENSP00000320567; ENSG00000090263.
ENST00000393008; ENSP00000376732; ENSG00000090263.
ENST00000469351; ENSP00000417287; ENSG00000090263.
ENST00000496958; ENSP00000418451; ENSG00000090263.
GeneIDi51650.
KEGGihsa:51650.
UCSCiuc003vwd.5. human.

Organism-specific databases

CTDi51650.
DisGeNETi51650.
GeneCardsiMRPS33.
HGNCiHGNC:16634. MRPS33.
HPAiHPA030425.
MIMi611993. gene.
neXtProtiNX_Q9Y291.
OpenTargetsiENSG00000090263.
PharmGKBiPA31020.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4104. Eukaryota.
ENOG4111X83. LUCA.
GeneTreeiENSGT00390000011401.
HOVERGENiHBG036129.
InParanoidiQ9Y291.
KOiK17411.
OMAiKEVYDWY.
OrthoDBiEOG091G0Y05.
PhylomeDBiQ9Y291.
TreeFamiTF313928.

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Miscellaneous databases

ChiTaRSiMRPS33. human.
GeneWikiiMRPS33.
GenomeRNAii51650.
PROiPR:Q9Y291.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000090263.
CleanExiHS_MRPS33.
ExpressionAtlasiQ9Y291. baseline and differential.
GenevisibleiQ9Y291. HS.

Family and domain databases

InterProiView protein in InterPro
IPR013219. Ribosomal_S27/S33_mit.
PANTHERiPTHR13362. PTHR13362. 1 hit.
PfamiView protein in Pfam
PF08293. MRP-S33. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRT33_HUMAN
AccessioniPrimary (citable) accession number: Q9Y291
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: November 1, 1999
Last modified: April 12, 2017
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.