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Protein

28S ribosomal protein S33, mitochondrial

Gene

MRPS33

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  1. mitochondrial translation Source: Reactome
  2. mitochondrial translational elongation Source: Reactome
  3. mitochondrial translational initiation Source: Reactome
  4. mitochondrial translational termination Source: Reactome
  5. organelle organization Source: Reactome
  6. translation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiREACT_267634. Mitochondrial translation initiation.
REACT_268133. Mitochondrial translation elongation.
REACT_268261. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S33, mitochondrial
Short name:
MRP-S33
Short name:
S33mt
Gene namesi
Name:MRPS33
ORF Names:CGI-139, PTD003
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:16634. MRPS33.

Subcellular locationi

Mitochondrion 1 Publication

GO - Cellular componenti

  1. mitochondrial inner membrane Source: Reactome
  2. mitochondrial small ribosomal subunit Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31020.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 10610528S ribosomal protein S33, mitochondrialPRO_0000087727Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine2 Publications

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9Y291.
PaxDbiQ9Y291.
PRIDEiQ9Y291.

PTM databases

PhosphoSiteiQ9Y291.

Expressioni

Gene expression databases

BgeeiQ9Y291.
CleanExiHS_MRPS33.
ExpressionAtlasiQ9Y291. baseline and differential.
GenevestigatoriQ9Y291.

Organism-specific databases

HPAiHPA030425.

Interactioni

Subunit structurei

Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

Protein-protein interaction databases

BioGridi119658. 12 interactions.
IntActiQ9Y291. 2 interactions.
STRINGi9606.ENSP00000320567.

Structurei

3D structure databases

ProteinModelPortaliQ9Y291.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG255077.
GeneTreeiENSGT00390000011401.
HOVERGENiHBG036129.
InParanoidiQ9Y291.
KOiK17411.
OMAiWYPRHVE.
OrthoDBiEOG70W3GJ.
PhylomeDBiQ9Y291.
TreeFamiTF313928.

Family and domain databases

InterProiIPR013219. Ribosomal_S27/S33_mit.
[Graphical view]
PfamiPF08293. MRP-S33. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y291-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSLSEYAFR MSRLSARLFG EVTRPTNSKS MKVVKLFSEL PLAKKKETYD
60 70 80 90 100
WYPNHHTYAE LMQTLRFLGL YRDEHQDFMD EQKRLKKLRG KEKPKKGEGK

RAAKRK
Length:106
Mass (Da):12,629
Last modified:November 1, 1999 - v1
Checksum:iE755EDAFB6AF6A46
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151897 mRNA. Translation: AAD34134.1.
AF078858 mRNA. Translation: AAD44490.1.
AC006006 Genomic DNA. Translation: AAD43190.1.
BC015462 mRNA. Translation: AAH15462.1.
CCDSiCCDS5864.1.
RefSeqiNP_057155.1. NM_016071.3.
NP_444263.1. NM_053035.2.
UniGeneiHs.416207.

Genome annotation databases

EnsembliENST00000324787; ENSP00000320567; ENSG00000090263.
ENST00000393008; ENSP00000376732; ENSG00000090263.
ENST00000469351; ENSP00000417287; ENSG00000090263.
ENST00000496958; ENSP00000418451; ENSG00000090263.
GeneIDi51650.
KEGGihsa:51650.
UCSCiuc003vwd.4. human.

Polymorphism databases

DMDMi24212388.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151897 mRNA. Translation: AAD34134.1.
AF078858 mRNA. Translation: AAD44490.1.
AC006006 Genomic DNA. Translation: AAD43190.1.
BC015462 mRNA. Translation: AAH15462.1.
CCDSiCCDS5864.1.
RefSeqiNP_057155.1. NM_016071.3.
NP_444263.1. NM_053035.2.
UniGeneiHs.416207.

3D structure databases

ProteinModelPortaliQ9Y291.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119658. 12 interactions.
IntActiQ9Y291. 2 interactions.
STRINGi9606.ENSP00000320567.

PTM databases

PhosphoSiteiQ9Y291.

Polymorphism databases

DMDMi24212388.

Proteomic databases

MaxQBiQ9Y291.
PaxDbiQ9Y291.
PRIDEiQ9Y291.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324787; ENSP00000320567; ENSG00000090263.
ENST00000393008; ENSP00000376732; ENSG00000090263.
ENST00000469351; ENSP00000417287; ENSG00000090263.
ENST00000496958; ENSP00000418451; ENSG00000090263.
GeneIDi51650.
KEGGihsa:51650.
UCSCiuc003vwd.4. human.

Organism-specific databases

CTDi51650.
GeneCardsiGC07M140705.
HGNCiHGNC:16634. MRPS33.
HPAiHPA030425.
MIMi611993. gene.
neXtProtiNX_Q9Y291.
PharmGKBiPA31020.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG255077.
GeneTreeiENSGT00390000011401.
HOVERGENiHBG036129.
InParanoidiQ9Y291.
KOiK17411.
OMAiWYPRHVE.
OrthoDBiEOG70W3GJ.
PhylomeDBiQ9Y291.
TreeFamiTF313928.

Enzyme and pathway databases

ReactomeiREACT_267634. Mitochondrial translation initiation.
REACT_268133. Mitochondrial translation elongation.
REACT_268261. Mitochondrial translation termination.

Miscellaneous databases

ChiTaRSiMRPS33. human.
GeneWikiiMRPS33.
GenomeRNAii51650.
NextBioi55604.
PROiQ9Y291.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y291.
CleanExiHS_MRPS33.
ExpressionAtlasiQ9Y291. baseline and differential.
GenevestigatoriQ9Y291.

Family and domain databases

InterProiIPR013219. Ribosomal_S27/S33_mit.
[Graphical view]
PfamiPF08293. MRP-S33. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
    Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
    Genome Res. 10:703-713(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. Dai M., Peng Y., Song H., Huang Q., Mao Y., Zhang Q., Mao M., Fu G., Luo M., Chen J., Hu R.
    Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary tumor.
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  5. "The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present."
    Koc E.C., Burkhart W., Blackburn K., Moseley A., Spremulli L.L.
    J. Biol. Chem. 276:19363-19374(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  8. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRT33_HUMAN
AccessioniPrimary (citable) accession number: Q9Y291
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: November 1, 1999
Last modified: April 1, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.