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Q9Y291

- RT33_HUMAN

UniProt

Q9Y291 - RT33_HUMAN

Protein

28S ribosomal protein S33, mitochondrial

Gene

MRPS33

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. structural constituent of ribosome Source: UniProtKB

    GO - Biological processi

    1. translation Source: UniProtKB

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    28S ribosomal protein S33, mitochondrial
    Short name:
    MRP-S33
    Short name:
    S33mt
    Gene namesi
    Name:MRPS33
    ORF Names:CGI-139, PTD003
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:16634. MRPS33.

    Subcellular locationi

    Mitochondrion 1 Publication

    GO - Cellular componenti

    1. mitochondrial small ribosomal subunit Source: UniProtKB

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31020.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 10610528S ribosomal protein S33, mitochondrialPRO_0000087727Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine2 Publications

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9Y291.
    PaxDbiQ9Y291.
    PRIDEiQ9Y291.

    PTM databases

    PhosphoSiteiQ9Y291.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Y291.
    BgeeiQ9Y291.
    CleanExiHS_MRPS33.
    GenevestigatoriQ9Y291.

    Organism-specific databases

    HPAiHPA030425.

    Interactioni

    Subunit structurei

    Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

    Protein-protein interaction databases

    BioGridi119658. 1 interaction.
    IntActiQ9Y291. 2 interactions.
    STRINGi9606.ENSP00000320567.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y291.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG255077.
    HOVERGENiHBG036129.
    InParanoidiQ9Y291.
    KOiK17411.
    OMAiKEVYDWY.
    OrthoDBiEOG70W3GJ.
    PhylomeDBiQ9Y291.
    TreeFamiTF313928.

    Family and domain databases

    InterProiIPR013219. Ribosomal_S27/S33_mit.
    [Graphical view]
    PfamiPF08293. MRP-S33. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9Y291-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSLSEYAFR MSRLSARLFG EVTRPTNSKS MKVVKLFSEL PLAKKKETYD    50
    WYPNHHTYAE LMQTLRFLGL YRDEHQDFMD EQKRLKKLRG KEKPKKGEGK 100
    RAAKRK 106
    Length:106
    Mass (Da):12,629
    Last modified:November 1, 1999 - v1
    Checksum:iE755EDAFB6AF6A46
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF151897 mRNA. Translation: AAD34134.1.
    AF078858 mRNA. Translation: AAD44490.1.
    AC006006 Genomic DNA. Translation: AAD43190.1.
    BC015462 mRNA. Translation: AAH15462.1.
    CCDSiCCDS5864.1.
    RefSeqiNP_057155.1. NM_016071.3.
    NP_444263.1. NM_053035.2.
    UniGeneiHs.416207.

    Genome annotation databases

    EnsembliENST00000324787; ENSP00000320567; ENSG00000090263.
    ENST00000393008; ENSP00000376732; ENSG00000090263.
    ENST00000469351; ENSP00000417287; ENSG00000090263.
    ENST00000496958; ENSP00000418451; ENSG00000090263.
    GeneIDi51650.
    KEGGihsa:51650.
    UCSCiuc003vwd.4. human.

    Polymorphism databases

    DMDMi24212388.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF151897 mRNA. Translation: AAD34134.1 .
    AF078858 mRNA. Translation: AAD44490.1 .
    AC006006 Genomic DNA. Translation: AAD43190.1 .
    BC015462 mRNA. Translation: AAH15462.1 .
    CCDSi CCDS5864.1.
    RefSeqi NP_057155.1. NM_016071.3.
    NP_444263.1. NM_053035.2.
    UniGenei Hs.416207.

    3D structure databases

    ProteinModelPortali Q9Y291.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119658. 1 interaction.
    IntActi Q9Y291. 2 interactions.
    STRINGi 9606.ENSP00000320567.

    PTM databases

    PhosphoSitei Q9Y291.

    Polymorphism databases

    DMDMi 24212388.

    Proteomic databases

    MaxQBi Q9Y291.
    PaxDbi Q9Y291.
    PRIDEi Q9Y291.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000324787 ; ENSP00000320567 ; ENSG00000090263 .
    ENST00000393008 ; ENSP00000376732 ; ENSG00000090263 .
    ENST00000469351 ; ENSP00000417287 ; ENSG00000090263 .
    ENST00000496958 ; ENSP00000418451 ; ENSG00000090263 .
    GeneIDi 51650.
    KEGGi hsa:51650.
    UCSCi uc003vwd.4. human.

    Organism-specific databases

    CTDi 51650.
    GeneCardsi GC07M140705.
    HGNCi HGNC:16634. MRPS33.
    HPAi HPA030425.
    MIMi 611993. gene.
    neXtProti NX_Q9Y291.
    PharmGKBi PA31020.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG255077.
    HOVERGENi HBG036129.
    InParanoidi Q9Y291.
    KOi K17411.
    OMAi KEVYDWY.
    OrthoDBi EOG70W3GJ.
    PhylomeDBi Q9Y291.
    TreeFami TF313928.

    Miscellaneous databases

    GeneWikii MRPS33.
    GenomeRNAii 51650.
    NextBioi 55604.
    PROi Q9Y291.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y291.
    Bgeei Q9Y291.
    CleanExi HS_MRPS33.
    Genevestigatori Q9Y291.

    Family and domain databases

    InterProi IPR013219. Ribosomal_S27/S33_mit.
    [Graphical view ]
    Pfami PF08293. MRP-S33. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
      Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
      Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. Dai M., Peng Y., Song H., Huang Q., Mao Y., Zhang Q., Mao M., Fu G., Luo M., Chen J., Hu R.
      Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pituitary tumor.
    3. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    5. "The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present."
      Koc E.C., Burkhart W., Blackburn K., Moseley A., Spremulli L.L.
      J. Biol. Chem. 276:19363-19374(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    8. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRT33_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y291
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2002
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3