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Q9Y289

- SC5A6_HUMAN

UniProt

Q9Y289 - SC5A6_HUMAN

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Protein

Sodium-dependent multivitamin transporter

Gene
SLC5A6, SMVT
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Transports pantothenate, biotin and lipoate in the presence of sodium.

GO - Molecular functioni

  1. sodium-dependent multivitamin transmembrane transporter activity Source: ProtInc

GO - Biological processi

  1. biotin metabolic process Source: Reactome
  2. biotin transport Source: Ensembl
  3. pantothenate metabolic process Source: Reactome
  4. pantothenate transmembrane transport Source: Ensembl
  5. small molecule metabolic process Source: Reactome
  6. transmembrane transport Source: Reactome
  7. transport Source: ProtInc
  8. vitamin metabolic process Source: Reactome
  9. water-soluble vitamin metabolic process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Biotin, Sodium

Enzyme and pathway databases

ReactomeiREACT_11153. Biotin transport and metabolism.
REACT_11172. Vitamin B5 (pantothenate) metabolism.
REACT_22285. Transport of vitamins, nucleosides, and related molecules.

Protein family/group databases

TCDBi2.A.21.5.7. the solute:sodium symporter (sss) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent multivitamin transporter
Short name:
Na(+)-dependent multivitamin transporter
Alternative name(s):
Solute carrier family 5 member 6
Gene namesi
Name:SLC5A6
Synonyms:SMVT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:11041. SLC5A6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei24 – 4421Helical; Reviewed predictionAdd
BLAST
Transmembranei68 – 8821Helical; Reviewed predictionAdd
BLAST
Transmembranei101 – 12121Helical; Reviewed predictionAdd
BLAST
Transmembranei143 – 16321Helical; Reviewed predictionAdd
BLAST
Transmembranei176 – 19621Helical; Reviewed predictionAdd
BLAST
Transmembranei199 – 21921Helical; Reviewed predictionAdd
BLAST
Transmembranei256 – 27621Helical; Reviewed predictionAdd
BLAST
Transmembranei297 – 31721Helical; Reviewed predictionAdd
BLAST
Transmembranei336 – 35621Helical; Reviewed predictionAdd
BLAST
Transmembranei396 – 41621Helical; Reviewed predictionAdd
BLAST
Transmembranei428 – 44821Helical; Reviewed predictionAdd
BLAST
Transmembranei456 – 47621Helical; Reviewed predictionAdd
BLAST
Transmembranei528 – 54821Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. brush border membrane Source: Ensembl
  2. integral component of plasma membrane Source: ProtInc
  3. membrane Source: ProtInc
  4. plasma membrane Source: Reactome
  5. vesicle membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA379.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 635635Sodium-dependent multivitamin transporterPRO_0000105386Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi138 – 1381N-linked (GlcNAc...) Reviewed prediction
Glycosylationi489 – 4891N-linked (GlcNAc...) Reviewed prediction
Glycosylationi498 – 4981N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9Y289.
PaxDbiQ9Y289.
PRIDEiQ9Y289.

PTM databases

PhosphoSiteiQ9Y289.

Expressioni

Gene expression databases

ArrayExpressiQ9Y289.
BgeeiQ9Y289.
CleanExiHS_SLC5A6.
GenevestigatoriQ9Y289.

Organism-specific databases

HPAiHPA036958.

Interactioni

Protein-protein interaction databases

BioGridi114403. 3 interactions.
IntActiQ9Y289. 1 interaction.
MINTiMINT-5005745.
STRINGi9606.ENSP00000310208.

Structurei

3D structure databases

ProteinModelPortaliQ9Y289.
SMRiQ9Y289. Positions 25-470.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0591.
HOGENOMiHOG000261662.
HOVERGENiHBG057280.
InParanoidiQ9Y289.
KOiK14386.
OMAiPWFPQFS.
OrthoDBiEOG70PBX7.
PhylomeDBiQ9Y289.
TreeFamiTF316728.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
IPR019900. Na/solute_symporter_subgr.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 1 hit.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y289-1 [UniParc]FASTAAdd to Basket

« Hide

MSVGVSTSAP LSPTSGTSVG MSTFSIMDYV VFVLLLVLSL AIGLYHACRG    50
WGRHTVGELL MADRKMGCLP VALSLLATFQ SAVAILGVPS EIYRFGTQYW 100
FLGCCYFLGL LIPAHIFIPV FYRLHLTSAY EYLELRFNKT VRVCGTVTFI 150
FQMVIYMGVV LYAPSLALNA VTGFDLWLSV LALGIVCTVY TALGGLKAVI 200
WTDVFQTLVM FLGQLAVIIV GSAKVGGLGR VWAVASQHGR ISGFELDPDP 250
FVRHTFWTLA FGGVFMMLSL YGVNQAQVQR YLSSRTEKAA VLSCYAVFPF 300
QQVSLCVGCL IGLVMFAYYQ EYPMSIQQAQ AAPDQFVLYF VMDLLKGLPG 350
LPGLFIACLF SGSLSTISSA FNSLATVTME DLIRPWFPEF SEARAIMLSR 400
GLAFGYGLLC LGMAYISSQM GPVLQAAISI FGMVGGPLLG LFCLGMFFPC 450
ANPPGAVVGL LAGLVMAFWI GIGSIVTSMG SSMPPSPSNG SSFSLPTNLT 500
VATVTTLMPL TTFSKPTGLQ RFYSLSYLWY SAHNSTTVIV VGLIVSLLTG 550
RMRGRSLNPA TIYPVLPKLL SLLPLSCQKR LHCRSYGQDH LDTGLFPEKP 600
RNGVLGDSRD KEAMALDGTA YQGSSSTCIL QETSL 635
Length:635
Mass (Da):68,642
Last modified:May 5, 2009 - v2
Checksum:i52A6E40DB337134F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti481 – 4811S → F.4 Publications
Corresponds to variant rs1395 [ dbSNP | Ensembl ].
VAR_052491
Natural varianti492 – 4921S → N.
Corresponds to variant rs1064845 [ dbSNP | Ensembl ].
VAR_052492

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF116241 Genomic DNA. Translation: AAD37502.1.
AF069307 mRNA. Translation: AAD31727.1.
AF081571 mRNA. Translation: AAD37481.1.
AK314545 mRNA. Translation: BAG37132.1.
AC013403 Genomic DNA. Translation: AAX93172.1.
CH471053 Genomic DNA. Translation: EAX00620.1.
CH471053 Genomic DNA. Translation: EAX00621.1.
CH471053 Genomic DNA. Translation: EAX00622.1.
BC012806 mRNA. Translation: AAH12806.1.
BC015631 mRNA. Translation: AAH15631.1.
CCDSiCCDS1740.1.
RefSeqiNP_066918.2. NM_021095.2.
XP_006712191.1. XM_006712128.1.
XP_006712192.1. XM_006712129.1.
XP_006712193.1. XM_006712130.1.
UniGeneiHs.435735.

Genome annotation databases

EnsembliENST00000310574; ENSP00000310208; ENSG00000138074.
ENST00000408041; ENSP00000384853; ENSG00000138074.
GeneIDi8884.
KEGGihsa:8884.
UCSCiuc002rjd.3. human.

Polymorphism databases

DMDMi229462745.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF116241 Genomic DNA. Translation: AAD37502.1 .
AF069307 mRNA. Translation: AAD31727.1 .
AF081571 mRNA. Translation: AAD37481.1 .
AK314545 mRNA. Translation: BAG37132.1 .
AC013403 Genomic DNA. Translation: AAX93172.1 .
CH471053 Genomic DNA. Translation: EAX00620.1 .
CH471053 Genomic DNA. Translation: EAX00621.1 .
CH471053 Genomic DNA. Translation: EAX00622.1 .
BC012806 mRNA. Translation: AAH12806.1 .
BC015631 mRNA. Translation: AAH15631.1 .
CCDSi CCDS1740.1.
RefSeqi NP_066918.2. NM_021095.2.
XP_006712191.1. XM_006712128.1.
XP_006712192.1. XM_006712129.1.
XP_006712193.1. XM_006712130.1.
UniGenei Hs.435735.

3D structure databases

ProteinModelPortali Q9Y289.
SMRi Q9Y289. Positions 25-470.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114403. 3 interactions.
IntActi Q9Y289. 1 interaction.
MINTi MINT-5005745.
STRINGi 9606.ENSP00000310208.

Chemistry

DrugBanki DB00121. Biotin.
DB00166. Lipoic Acid.

Protein family/group databases

TCDBi 2.A.21.5.7. the solute:sodium symporter (sss) family.

PTM databases

PhosphoSitei Q9Y289.

Polymorphism databases

DMDMi 229462745.

Proteomic databases

MaxQBi Q9Y289.
PaxDbi Q9Y289.
PRIDEi Q9Y289.

Protocols and materials databases

DNASUi 8884.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000310574 ; ENSP00000310208 ; ENSG00000138074 .
ENST00000408041 ; ENSP00000384853 ; ENSG00000138074 .
GeneIDi 8884.
KEGGi hsa:8884.
UCSCi uc002rjd.3. human.

Organism-specific databases

CTDi 8884.
GeneCardsi GC02M027422.
HGNCi HGNC:11041. SLC5A6.
HPAi HPA036958.
MIMi 604024. gene.
neXtProti NX_Q9Y289.
PharmGKBi PA379.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0591.
HOGENOMi HOG000261662.
HOVERGENi HBG057280.
InParanoidi Q9Y289.
KOi K14386.
OMAi PWFPQFS.
OrthoDBi EOG70PBX7.
PhylomeDBi Q9Y289.
TreeFami TF316728.

Enzyme and pathway databases

Reactomei REACT_11153. Biotin transport and metabolism.
REACT_11172. Vitamin B5 (pantothenate) metabolism.
REACT_22285. Transport of vitamins, nucleosides, and related molecules.

Miscellaneous databases

ChiTaRSi SLC5A6. human.
GeneWikii SLC5A6.
GenomeRNAii 8884.
NextBioi 33365.
PROi Q9Y289.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9Y289.
Bgeei Q9Y289.
CleanExi HS_SLC5A6.
Genevestigatori Q9Y289.

Family and domain databases

InterProi IPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
IPR019900. Na/solute_symporter_subgr.
[Graphical view ]
PANTHERi PTHR11819. PTHR11819. 1 hit.
Pfami PF00474. SSF. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00813. sss. 1 hit.
PROSITEi PS00456. NA_SOLUT_SYMP_1. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human placental Na+-dependent multivitamin transporter. Cloning, functional expression, gene structure, and chromosomal localization."
    Wang H., Huang W., Fei Y.-J., Xia H., Yang-Feng T.L., Leibach F.H., Devoe L.D., Ganapathy V., Prasad P.D.
    J. Biol. Chem. 274:14875-14883(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANT PHE-481.
    Tissue: Intestine.
  2. "Molecular and functional characterization of the intestinal Na+-dependent multivitamin transporter."
    Prasad P.D., Wang H., Huang W., Fei Y.-J., Leibach F.H., Devoe L.D., Ganapathy V.
    Arch. Biochem. Biophys. 366:95-106(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PHE-481.
    Tissue: Intestine.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-481.
    Tissue: Placenta.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PHE-481.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiSC5A6_HUMAN
AccessioniPrimary (citable) accession number: Q9Y289
Secondary accession number(s): B2RB85, D6W549, Q969Y5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 5, 2009
Last modified: September 3, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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