Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9Y289

- SC5A6_HUMAN

UniProt

Q9Y289 - SC5A6_HUMAN

Protein

Sodium-dependent multivitamin transporter

Gene

SLC5A6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 2 (05 May 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Transports pantothenate, biotin and lipoate in the presence of sodium.

    GO - Molecular functioni

    1. sodium-dependent multivitamin transmembrane transporter activity Source: ProtInc

    GO - Biological processi

    1. biotin metabolic process Source: Reactome
    2. biotin transport Source: Ensembl
    3. pantothenate metabolic process Source: Reactome
    4. pantothenate transmembrane transport Source: Ensembl
    5. small molecule metabolic process Source: Reactome
    6. transmembrane transport Source: Reactome
    7. transport Source: ProtInc
    8. vitamin metabolic process Source: Reactome
    9. water-soluble vitamin metabolic process Source: Reactome

    Keywords - Biological processi

    Ion transport, Sodium transport, Symport, Transport

    Keywords - Ligandi

    Biotin, Sodium

    Enzyme and pathway databases

    ReactomeiREACT_11153. Biotin transport and metabolism.
    REACT_11172. Vitamin B5 (pantothenate) metabolism.
    REACT_22285. Transport of vitamins, nucleosides, and related molecules.

    Protein family/group databases

    TCDBi2.A.21.5.7. the solute:sodium symporter (sss) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium-dependent multivitamin transporter
    Short name:
    Na(+)-dependent multivitamin transporter
    Alternative name(s):
    Solute carrier family 5 member 6
    Gene namesi
    Name:SLC5A6
    Synonyms:SMVT
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:11041. SLC5A6.

    Subcellular locationi

    GO - Cellular componenti

    1. brush border membrane Source: Ensembl
    2. integral component of plasma membrane Source: ProtInc
    3. membrane Source: ProtInc
    4. plasma membrane Source: Reactome
    5. vesicle membrane Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA379.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 635635Sodium-dependent multivitamin transporterPRO_0000105386Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi138 – 1381N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi489 – 4891N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi498 – 4981N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ9Y289.
    PaxDbiQ9Y289.
    PRIDEiQ9Y289.

    PTM databases

    PhosphoSiteiQ9Y289.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Y289.
    BgeeiQ9Y289.
    CleanExiHS_SLC5A6.
    GenevestigatoriQ9Y289.

    Organism-specific databases

    HPAiHPA036958.

    Interactioni

    Protein-protein interaction databases

    BioGridi114403. 3 interactions.
    IntActiQ9Y289. 1 interaction.
    MINTiMINT-5005745.
    STRINGi9606.ENSP00000310208.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y289.
    SMRiQ9Y289. Positions 25-470.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei24 – 4421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei68 – 8821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei101 – 12121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei143 – 16321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei176 – 19621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei199 – 21921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei256 – 27621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei297 – 31721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei336 – 35621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei396 – 41621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei428 – 44821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei456 – 47621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei528 – 54821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0591.
    HOGENOMiHOG000261662.
    HOVERGENiHBG057280.
    InParanoidiQ9Y289.
    KOiK14386.
    OMAiPWFPQFS.
    OrthoDBiEOG70PBX7.
    PhylomeDBiQ9Y289.
    TreeFamiTF316728.

    Family and domain databases

    InterProiIPR001734. Na/solute_symporter.
    IPR018212. Na/solute_symporter_CS.
    IPR019900. Na/solute_symporter_subgr.
    [Graphical view]
    PANTHERiPTHR11819. PTHR11819. 1 hit.
    PfamiPF00474. SSF. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00813. sss. 1 hit.
    PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
    PS50283. NA_SOLUT_SYMP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Y289-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVGVSTSAP LSPTSGTSVG MSTFSIMDYV VFVLLLVLSL AIGLYHACRG    50
    WGRHTVGELL MADRKMGCLP VALSLLATFQ SAVAILGVPS EIYRFGTQYW 100
    FLGCCYFLGL LIPAHIFIPV FYRLHLTSAY EYLELRFNKT VRVCGTVTFI 150
    FQMVIYMGVV LYAPSLALNA VTGFDLWLSV LALGIVCTVY TALGGLKAVI 200
    WTDVFQTLVM FLGQLAVIIV GSAKVGGLGR VWAVASQHGR ISGFELDPDP 250
    FVRHTFWTLA FGGVFMMLSL YGVNQAQVQR YLSSRTEKAA VLSCYAVFPF 300
    QQVSLCVGCL IGLVMFAYYQ EYPMSIQQAQ AAPDQFVLYF VMDLLKGLPG 350
    LPGLFIACLF SGSLSTISSA FNSLATVTME DLIRPWFPEF SEARAIMLSR 400
    GLAFGYGLLC LGMAYISSQM GPVLQAAISI FGMVGGPLLG LFCLGMFFPC 450
    ANPPGAVVGL LAGLVMAFWI GIGSIVTSMG SSMPPSPSNG SSFSLPTNLT 500
    VATVTTLMPL TTFSKPTGLQ RFYSLSYLWY SAHNSTTVIV VGLIVSLLTG 550
    RMRGRSLNPA TIYPVLPKLL SLLPLSCQKR LHCRSYGQDH LDTGLFPEKP 600
    RNGVLGDSRD KEAMALDGTA YQGSSSTCIL QETSL 635
    Length:635
    Mass (Da):68,642
    Last modified:May 5, 2009 - v2
    Checksum:i52A6E40DB337134F
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti481 – 4811S → F.4 Publications
    Corresponds to variant rs1395 [ dbSNP | Ensembl ].
    VAR_052491
    Natural varianti492 – 4921S → N.
    Corresponds to variant rs1064845 [ dbSNP | Ensembl ].
    VAR_052492

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF116241 Genomic DNA. Translation: AAD37502.1.
    AF069307 mRNA. Translation: AAD31727.1.
    AF081571 mRNA. Translation: AAD37481.1.
    AK314545 mRNA. Translation: BAG37132.1.
    AC013403 Genomic DNA. Translation: AAX93172.1.
    CH471053 Genomic DNA. Translation: EAX00620.1.
    CH471053 Genomic DNA. Translation: EAX00621.1.
    CH471053 Genomic DNA. Translation: EAX00622.1.
    BC012806 mRNA. Translation: AAH12806.1.
    BC015631 mRNA. Translation: AAH15631.1.
    CCDSiCCDS1740.1.
    RefSeqiNP_066918.2. NM_021095.2.
    XP_006712191.1. XM_006712128.1.
    XP_006712192.1. XM_006712129.1.
    XP_006712193.1. XM_006712130.1.
    UniGeneiHs.435735.

    Genome annotation databases

    EnsembliENST00000310574; ENSP00000310208; ENSG00000138074.
    ENST00000408041; ENSP00000384853; ENSG00000138074.
    GeneIDi8884.
    KEGGihsa:8884.
    UCSCiuc002rjd.3. human.

    Polymorphism databases

    DMDMi229462745.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF116241 Genomic DNA. Translation: AAD37502.1 .
    AF069307 mRNA. Translation: AAD31727.1 .
    AF081571 mRNA. Translation: AAD37481.1 .
    AK314545 mRNA. Translation: BAG37132.1 .
    AC013403 Genomic DNA. Translation: AAX93172.1 .
    CH471053 Genomic DNA. Translation: EAX00620.1 .
    CH471053 Genomic DNA. Translation: EAX00621.1 .
    CH471053 Genomic DNA. Translation: EAX00622.1 .
    BC012806 mRNA. Translation: AAH12806.1 .
    BC015631 mRNA. Translation: AAH15631.1 .
    CCDSi CCDS1740.1.
    RefSeqi NP_066918.2. NM_021095.2.
    XP_006712191.1. XM_006712128.1.
    XP_006712192.1. XM_006712129.1.
    XP_006712193.1. XM_006712130.1.
    UniGenei Hs.435735.

    3D structure databases

    ProteinModelPortali Q9Y289.
    SMRi Q9Y289. Positions 25-470.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114403. 3 interactions.
    IntActi Q9Y289. 1 interaction.
    MINTi MINT-5005745.
    STRINGi 9606.ENSP00000310208.

    Chemistry

    DrugBanki DB00121. Biotin.
    DB00166. Lipoic Acid.

    Protein family/group databases

    TCDBi 2.A.21.5.7. the solute:sodium symporter (sss) family.

    PTM databases

    PhosphoSitei Q9Y289.

    Polymorphism databases

    DMDMi 229462745.

    Proteomic databases

    MaxQBi Q9Y289.
    PaxDbi Q9Y289.
    PRIDEi Q9Y289.

    Protocols and materials databases

    DNASUi 8884.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000310574 ; ENSP00000310208 ; ENSG00000138074 .
    ENST00000408041 ; ENSP00000384853 ; ENSG00000138074 .
    GeneIDi 8884.
    KEGGi hsa:8884.
    UCSCi uc002rjd.3. human.

    Organism-specific databases

    CTDi 8884.
    GeneCardsi GC02M027422.
    HGNCi HGNC:11041. SLC5A6.
    HPAi HPA036958.
    MIMi 604024. gene.
    neXtProti NX_Q9Y289.
    PharmGKBi PA379.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0591.
    HOGENOMi HOG000261662.
    HOVERGENi HBG057280.
    InParanoidi Q9Y289.
    KOi K14386.
    OMAi PWFPQFS.
    OrthoDBi EOG70PBX7.
    PhylomeDBi Q9Y289.
    TreeFami TF316728.

    Enzyme and pathway databases

    Reactomei REACT_11153. Biotin transport and metabolism.
    REACT_11172. Vitamin B5 (pantothenate) metabolism.
    REACT_22285. Transport of vitamins, nucleosides, and related molecules.

    Miscellaneous databases

    ChiTaRSi SLC5A6. human.
    GeneWikii SLC5A6.
    GenomeRNAii 8884.
    NextBioi 33365.
    PROi Q9Y289.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y289.
    Bgeei Q9Y289.
    CleanExi HS_SLC5A6.
    Genevestigatori Q9Y289.

    Family and domain databases

    InterProi IPR001734. Na/solute_symporter.
    IPR018212. Na/solute_symporter_CS.
    IPR019900. Na/solute_symporter_subgr.
    [Graphical view ]
    PANTHERi PTHR11819. PTHR11819. 1 hit.
    Pfami PF00474. SSF. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00813. sss. 1 hit.
    PROSITEi PS00456. NA_SOLUT_SYMP_1. 1 hit.
    PS50283. NA_SOLUT_SYMP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human placental Na+-dependent multivitamin transporter. Cloning, functional expression, gene structure, and chromosomal localization."
      Wang H., Huang W., Fei Y.-J., Xia H., Yang-Feng T.L., Leibach F.H., Devoe L.D., Ganapathy V., Prasad P.D.
      J. Biol. Chem. 274:14875-14883(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANT PHE-481.
      Tissue: Intestine.
    2. "Molecular and functional characterization of the intestinal Na+-dependent multivitamin transporter."
      Prasad P.D., Wang H., Huang W., Fei Y.-J., Leibach F.H., Devoe L.D., Ganapathy V.
      Arch. Biochem. Biophys. 366:95-106(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PHE-481.
      Tissue: Intestine.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-481.
      Tissue: Placenta.
    4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PHE-481.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiSC5A6_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y289
    Secondary accession number(s): B2RB85, D6W549, Q969Y5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2001
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3