Q9Y289 (SC5A6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sodium-dependent multivitamin transporter
Short name=Na(+)-dependent multivitamin transporter

Alternative name(s):
Solute carrier family 5 member 6

Gene names

Name:	SLC5A6
Synonyms:	SMVT

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	635 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Transports pantothenate, biotin and lipoate in the presence of sodium.
Subcellular location	Membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. [View classification]

Ontologies

Keywords
Biological process	Ion transport Sodium transport Symport Transport
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	Biotin Sodium
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	biotin metabolic process Traceable author statement. Source: Reactome biotin transport Inferred from electronic annotation. Source: Compara pantothenate metabolic process Traceable author statement. Source: Reactome pantothenate transmembrane transport Inferred from electronic annotation. Source: Compara
Cellular_component	brush border membrane Inferred from electronic annotation. Source: Compara integral to plasma membrane Traceable author statement PubMed 9516450. Source: ProtInc vesicle membrane Inferred from electronic annotation. Source: Compara
Molecular_function	sodium-dependent multivitamin transmembrane transporter activity Traceable author statement PubMed 9516450. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 635	635	Sodium-dependent multivitamin transporter		PRO_0000105386
Regions
	Transmembrane	24 – 44	21	Helical; Potential
	Transmembrane	68 – 88	21	Helical; Potential
	Transmembrane	101 – 121	21	Helical; Potential
	Transmembrane	143 – 163	21	Helical; Potential
	Transmembrane	176 – 196	21	Helical; Potential
	Transmembrane	199 – 219	21	Helical; Potential
	Transmembrane	256 – 276	21	Helical; Potential
	Transmembrane	297 – 317	21	Helical; Potential
	Transmembrane	336 – 356	21	Helical; Potential
	Transmembrane	396 – 416	21	Helical; Potential
	Transmembrane	428 – 448	21	Helical; Potential
	Transmembrane	456 – 476	21	Helical; Potential
	Transmembrane	528 – 548	21	Helical; Potential
Amino acid modifications
	Glycosylation	138	1	N-linked (GlcNAc...) Potential
	Glycosylation	489	1	N-linked (GlcNAc...) Potential
	Glycosylation	498	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	481	1	S → F. Ref.1 Ref.2 Ref.3 Ref.5 Corresponds to variant rs1395 [ dbSNP | Ensembl ].		VAR_052491
	Natural variant	492	1	S → N. Corresponds to variant rs1064845 [ dbSNP | Ensembl ].		VAR_052492

Sequences

	Sequence		Length	Mass (Da)
	Q9Y289 [UniParc]. Last modified May 5, 2009. Version 2. Checksum: 52A6E40DB337134F	FASTA	635	68,642
	10 20 30 40 50 60 MSVGVSTSAP LSPTSGTSVG MSTFSIMDYV VFVLLLVLSL AIGLYHACRG WGRHTVGELL 70 80 90 100 110 120 MADRKMGCLP VALSLLATFQ SAVAILGVPS EIYRFGTQYW FLGCCYFLGL LIPAHIFIPV 130 140 150 160 170 180 FYRLHLTSAY EYLELRFNKT VRVCGTVTFI FQMVIYMGVV LYAPSLALNA VTGFDLWLSV 190 200 210 220 230 240 LALGIVCTVY TALGGLKAVI WTDVFQTLVM FLGQLAVIIV GSAKVGGLGR VWAVASQHGR 250 260 270 280 290 300 ISGFELDPDP FVRHTFWTLA FGGVFMMLSL YGVNQAQVQR YLSSRTEKAA VLSCYAVFPF 310 320 330 340 350 360 QQVSLCVGCL IGLVMFAYYQ EYPMSIQQAQ AAPDQFVLYF VMDLLKGLPG LPGLFIACLF 370 380 390 400 410 420 SGSLSTISSA FNSLATVTME DLIRPWFPEF SEARAIMLSR GLAFGYGLLC LGMAYISSQM 430 440 450 460 470 480 GPVLQAAISI FGMVGGPLLG LFCLGMFFPC ANPPGAVVGL LAGLVMAFWI GIGSIVTSMG 490 500 510 520 530 540 SSMPPSPSNG SSFSLPTNLT VATVTTLMPL TTFSKPTGLQ RFYSLSYLWY SAHNSTTVIV 550 560 570 580 590 600 VGLIVSLLTG RMRGRSLNPA TIYPVLPKLL SLLPLSCQKR LHCRSYGQDH LDTGLFPEKP 610 620 630 RNGVLGDSRD KEAMALDGTA YQGSSSTCIL QETSL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human placental Na+-dependent multivitamin transporter. Cloning, functional expression, gene structure, and chromosomal localization." Wang H., Huang W., Fei Y.-J., Xia H., Yang-Feng T.L., Leibach F.H., Devoe L.D., Ganapathy V., Prasad P.D. J. Biol. Chem. 274:14875-14883(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANT PHE-481. Tissue: Intestine.
[2]	"Molecular and functional characterization of the intestinal Na+-dependent multivitamin transporter." Prasad P.D., Wang H., Huang W., Fei Y.-J., Leibach F.H., Devoe L.D., Ganapathy V. Arch. Biochem. Biophys. 366:95-106(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PHE-481. Tissue: Intestine.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-481. Tissue: Placenta.
[4]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PHE-481.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF116241 Genomic DNA. Translation: AAD37502.1. AF069307 mRNA. Translation: AAD31727.1. AF081571 mRNA. Translation: AAD37481.1. AK314545 mRNA. Translation: BAG37132.1. AC013403 Genomic DNA. Translation: AAX93172.1. CH471053 Genomic DNA. Translation: EAX00620.1. CH471053 Genomic DNA. Translation: EAX00621.1. CH471053 Genomic DNA. Translation: EAX00622.1. BC012806 mRNA. Translation: AAH12806.1. BC015631 mRNA. Translation: AAH15631.1.
IPI	IPI00031822.
RefSeq	NP_066918.2. NM_021095.2.
UniGene	Hs.435735.
3D structure databases
ProteinModelPortal	Q9Y289.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y289. 1 interaction.
STRING	9606.ENSP00000310208.
PTM databases
PhosphoSite	Q9Y289.
Polymorphism databases
DMDM	229462745.
Proteomic databases
PaxDb	Q9Y289.
PRIDE	Q9Y289.
Protocols and materials databases
DNASU	8884.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000310574; ENSP00000310208; ENSG00000138074. ENST00000408041; ENSP00000384853; ENSG00000138074.
GeneID	8884.
KEGG	hsa:8884.
UCSC	uc002rjd.3. human.
Organism-specific databases
CTD	8884.
GeneCards	GC02M027422.
HGNC	HGNC:11041. SLC5A6.
HPA	HPA036958.
MIM	604024. gene.
neXtProt	NX_Q9Y289.
PharmGKB	PA379.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0591.
HOGENOM	HOG000261662.
HOVERGEN	HBG057280.
InParanoid	Q9Y289.
KO	K14386.
OMA	CMSCLIG.
OrthoDB	EOG4X6C80.
PhylomeDB	Q9Y289.
Enzyme and pathway databases
Reactome	REACT_111217. Metabolism. REACT_15518. Transmembrane transport of small molecules.
Gene expression databases
ArrayExpress	Q9Y289.
Bgee	Q9Y289.
CleanEx	HS_SLC5A6.
Genevestigator	Q9Y289.
GermOnline	ENSG00000138074. Homo sapiens.
Family and domain databases
InterPro	IPR001734. Na/solute_symporter. IPR018212. Na/solute_symporter_CS. IPR019900. Na/solute_symporter_subgr. [Graphical view]
PANTHER	PTHR11819. PTHR11819. 1 hit.
Pfam	PF00474. SSF. 1 hit. [Graphical view]
TIGRFAMs	TIGR00813. sss. 1 hit.
PROSITE	PS00456. NA_SOLUT_SYMP_1. 1 hit. PS00457. NA_SOLUT_SYMP_2. False negative. PS50283. NA_SOLUT_SYMP_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SLC5A6. human.
DrugBank	DB00121. Biotin. DB00166. Lipoic Acid.
GenomeRNAi	8884.
NextBio	33365.
SOURCE	Search...

Entry information

Entry name

SC5A6_HUMAN

Accession

Primary (citable) accession number: Q9Y289
Secondary accession number(s): B2RB85, D6W549, Q969Y5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2001
Last sequence update:	May 5, 2009
Last modified:	April 3, 2013
This is version 103 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.