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Q9Y289 (SC5A6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sodium-dependent multivitamin transporter

Short name=Na(+)-dependent multivitamin transporter
Alternative name(s):
Solute carrier family 5 member 6
Gene names
Name:SLC5A6
Synonyms:SMVT
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length635 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transports pantothenate, biotin and lipoate in the presence of sodium.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. [View classification]

Ontologies

Keywords
   Biological processIon transport
Sodium transport
Symport
Transport
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   LigandBiotin
Sodium
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processbiotin metabolic process

Traceable author statement. Source: Reactome

biotin transport

Inferred from electronic annotation. Source: Ensembl

pantothenate metabolic process

Traceable author statement. Source: Reactome

pantothenate transmembrane transport

Inferred from electronic annotation. Source: Ensembl

small molecule metabolic process

Traceable author statement. Source: Reactome

transmembrane transport

Traceable author statement. Source: Reactome

transport

Traceable author statement PubMed 9516450. Source: ProtInc

vitamin metabolic process

Traceable author statement. Source: Reactome

water-soluble vitamin metabolic process

Traceable author statement. Source: Reactome

   Cellular_componentbrush border membrane

Inferred from electronic annotation. Source: Ensembl

integral component of plasma membrane

Traceable author statement PubMed 9516450. Source: ProtInc

membrane

Traceable author statement PubMed 9516450. Source: ProtInc

plasma membrane

Traceable author statement. Source: Reactome

vesicle membrane

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionsodium-dependent multivitamin transmembrane transporter activity

Traceable author statement PubMed 9516450. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 635635Sodium-dependent multivitamin transporter
PRO_0000105386

Regions

Transmembrane24 – 4421Helical; Potential
Transmembrane68 – 8821Helical; Potential
Transmembrane101 – 12121Helical; Potential
Transmembrane143 – 16321Helical; Potential
Transmembrane176 – 19621Helical; Potential
Transmembrane199 – 21921Helical; Potential
Transmembrane256 – 27621Helical; Potential
Transmembrane297 – 31721Helical; Potential
Transmembrane336 – 35621Helical; Potential
Transmembrane396 – 41621Helical; Potential
Transmembrane428 – 44821Helical; Potential
Transmembrane456 – 47621Helical; Potential
Transmembrane528 – 54821Helical; Potential

Amino acid modifications

Glycosylation1381N-linked (GlcNAc...) Potential
Glycosylation4891N-linked (GlcNAc...) Potential
Glycosylation4981N-linked (GlcNAc...) Potential

Natural variations

Natural variant4811S → F. Ref.1 Ref.2 Ref.3 Ref.5
Corresponds to variant rs1395 [ dbSNP | Ensembl ].
VAR_052491
Natural variant4921S → N.
Corresponds to variant rs1064845 [ dbSNP | Ensembl ].
VAR_052492

Sequences

Sequence LengthMass (Da)Tools
Q9Y289 [UniParc].

Last modified May 5, 2009. Version 2.
Checksum: 52A6E40DB337134F

FASTA63568,642
        10         20         30         40         50         60 
MSVGVSTSAP LSPTSGTSVG MSTFSIMDYV VFVLLLVLSL AIGLYHACRG WGRHTVGELL 

        70         80         90        100        110        120 
MADRKMGCLP VALSLLATFQ SAVAILGVPS EIYRFGTQYW FLGCCYFLGL LIPAHIFIPV 

       130        140        150        160        170        180 
FYRLHLTSAY EYLELRFNKT VRVCGTVTFI FQMVIYMGVV LYAPSLALNA VTGFDLWLSV 

       190        200        210        220        230        240 
LALGIVCTVY TALGGLKAVI WTDVFQTLVM FLGQLAVIIV GSAKVGGLGR VWAVASQHGR 

       250        260        270        280        290        300 
ISGFELDPDP FVRHTFWTLA FGGVFMMLSL YGVNQAQVQR YLSSRTEKAA VLSCYAVFPF 

       310        320        330        340        350        360 
QQVSLCVGCL IGLVMFAYYQ EYPMSIQQAQ AAPDQFVLYF VMDLLKGLPG LPGLFIACLF 

       370        380        390        400        410        420 
SGSLSTISSA FNSLATVTME DLIRPWFPEF SEARAIMLSR GLAFGYGLLC LGMAYISSQM 

       430        440        450        460        470        480 
GPVLQAAISI FGMVGGPLLG LFCLGMFFPC ANPPGAVVGL LAGLVMAFWI GIGSIVTSMG 

       490        500        510        520        530        540 
SSMPPSPSNG SSFSLPTNLT VATVTTLMPL TTFSKPTGLQ RFYSLSYLWY SAHNSTTVIV 

       550        560        570        580        590        600 
VGLIVSLLTG RMRGRSLNPA TIYPVLPKLL SLLPLSCQKR LHCRSYGQDH LDTGLFPEKP 

       610        620        630 
RNGVLGDSRD KEAMALDGTA YQGSSSTCIL QETSL 

« Hide

References

« Hide 'large scale' references
[1]"Human placental Na+-dependent multivitamin transporter. Cloning, functional expression, gene structure, and chromosomal localization."
Wang H., Huang W., Fei Y.-J., Xia H., Yang-Feng T.L., Leibach F.H., Devoe L.D., Ganapathy V., Prasad P.D.
J. Biol. Chem. 274:14875-14883(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANT PHE-481.
Tissue: Intestine.
[2]"Molecular and functional characterization of the intestinal Na+-dependent multivitamin transporter."
Prasad P.D., Wang H., Huang W., Fei Y.-J., Leibach F.H., Devoe L.D., Ganapathy V.
Arch. Biochem. Biophys. 366:95-106(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PHE-481.
Tissue: Intestine.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-481.
Tissue: Placenta.
[4]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PHE-481.
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF116241 Genomic DNA. Translation: AAD37502.1.
AF069307 mRNA. Translation: AAD31727.1.
AF081571 mRNA. Translation: AAD37481.1.
AK314545 mRNA. Translation: BAG37132.1.
AC013403 Genomic DNA. Translation: AAX93172.1.
CH471053 Genomic DNA. Translation: EAX00620.1.
CH471053 Genomic DNA. Translation: EAX00621.1.
CH471053 Genomic DNA. Translation: EAX00622.1.
BC012806 mRNA. Translation: AAH12806.1.
BC015631 mRNA. Translation: AAH15631.1.
RefSeqNP_066918.2. NM_021095.2.
UniGeneHs.435735.

3D structure databases

ProteinModelPortalQ9Y289.
SMRQ9Y289. Positions 25-470.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114403. 3 interactions.
IntActQ9Y289. 1 interaction.
MINTMINT-5005745.
STRING9606.ENSP00000310208.

Chemistry

DrugBankDB00121. Biotin.
DB00166. Lipoic Acid.

Protein family/group databases

TCDB2.A.21.5.7. the solute:sodium symporter (sss) family.

PTM databases

PhosphoSiteQ9Y289.

Polymorphism databases

DMDM229462745.

Proteomic databases

PaxDbQ9Y289.
PRIDEQ9Y289.

Protocols and materials databases

DNASU8884.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000310574; ENSP00000310208; ENSG00000138074.
ENST00000408041; ENSP00000384853; ENSG00000138074.
GeneID8884.
KEGGhsa:8884.
UCSCuc002rjd.3. human.

Organism-specific databases

CTD8884.
GeneCardsGC02M027422.
HGNCHGNC:11041. SLC5A6.
HPAHPA036958.
MIM604024. gene.
neXtProtNX_Q9Y289.
PharmGKBPA379.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0591.
HOGENOMHOG000261662.
HOVERGENHBG057280.
InParanoidQ9Y289.
KOK14386.
OMAPWFPQFS.
OrthoDBEOG70PBX7.
PhylomeDBQ9Y289.
TreeFamTF316728.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.
REACT_116125. Disease.
REACT_15518. Transmembrane transport of small molecules.

Gene expression databases

ArrayExpressQ9Y289.
BgeeQ9Y289.
CleanExHS_SLC5A6.
GenevestigatorQ9Y289.

Family and domain databases

InterProIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
IPR019900. Na/solute_symporter_subgr.
[Graphical view]
PANTHERPTHR11819. PTHR11819. 1 hit.
PfamPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsTIGR00813. sss. 1 hit.
PROSITEPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSLC5A6. human.
GeneWikiSLC5A6.
GenomeRNAi8884.
NextBio33365.
PROQ9Y289.
SOURCESearch...

Entry information

Entry nameSC5A6_HUMAN
AccessionPrimary (citable) accession number: Q9Y289
Secondary accession number(s): B2RB85, D6W549, Q969Y5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 5, 2009
Last modified: April 16, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM