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Protein

Sodium-dependent multivitamin transporter

Gene

SLC5A6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transports pantothenate, biotin and lipoate in the presence of sodium.

GO - Molecular functioni

  • sodium-dependent multivitamin transmembrane transporter activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Biotin, Sodium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000138074-MONOMER.
ReactomeiR-HSA-196780. Biotin transport and metabolism.
R-HSA-199220. Vitamin B5 (pantothenate) metabolism.
R-HSA-425397. Transport of vitamins, nucleosides, and related molecules.

Protein family/group databases

TCDBi2.A.21.5.7. the solute:sodium symporter (sss) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent multivitamin transporter
Short name:
Na(+)-dependent multivitamin transporter
Alternative name(s):
Solute carrier family 5 member 6
Gene namesi
Name:SLC5A6
Synonyms:SMVT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:11041. SLC5A6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei24 – 44HelicalSequence analysisAdd BLAST21
Transmembranei68 – 88HelicalSequence analysisAdd BLAST21
Transmembranei101 – 121HelicalSequence analysisAdd BLAST21
Transmembranei143 – 163HelicalSequence analysisAdd BLAST21
Transmembranei176 – 196HelicalSequence analysisAdd BLAST21
Transmembranei199 – 219HelicalSequence analysisAdd BLAST21
Transmembranei256 – 276HelicalSequence analysisAdd BLAST21
Transmembranei297 – 317HelicalSequence analysisAdd BLAST21
Transmembranei336 – 356HelicalSequence analysisAdd BLAST21
Transmembranei396 – 416HelicalSequence analysisAdd BLAST21
Transmembranei428 – 448HelicalSequence analysisAdd BLAST21
Transmembranei456 – 476HelicalSequence analysisAdd BLAST21
Transmembranei528 – 548HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • brush border membrane Source: Ensembl
  • integral component of plasma membrane Source: ProtInc
  • membrane Source: ProtInc
  • plasma membrane Source: Reactome
  • vesicle membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8884.
OpenTargetsiENSG00000138074.
PharmGKBiPA379.

Chemistry databases

DrugBankiDB00121. Biotin.
DB08872. gabapentin enacarbil.
DB00166. Lipoic Acid.

Polymorphism and mutation databases

BioMutaiSLC5A6.
DMDMi229462745.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001053861 – 635Sodium-dependent multivitamin transporterAdd BLAST635

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi138N-linked (GlcNAc...)Sequence analysis1
Glycosylationi489N-linked (GlcNAc...)Sequence analysis1
Glycosylationi498N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9Y289.
MaxQBiQ9Y289.
PaxDbiQ9Y289.
PeptideAtlasiQ9Y289.
PRIDEiQ9Y289.

PTM databases

iPTMnetiQ9Y289.
PhosphoSitePlusiQ9Y289.
SwissPalmiQ9Y289.

Expressioni

Gene expression databases

BgeeiENSG00000138074.
CleanExiHS_SLC5A6.
ExpressionAtlasiQ9Y289. baseline and differential.
GenevisibleiQ9Y289. HS.

Organism-specific databases

HPAiHPA036958.

Interactioni

Protein-protein interaction databases

BioGridi114403. 4 interactors.
IntActiQ9Y289. 2 interactors.
MINTiMINT-5005745.
STRINGi9606.ENSP00000310208.

Structurei

3D structure databases

ProteinModelPortaliQ9Y289.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2349. Eukaryota.
COG0591. LUCA.
GeneTreeiENSGT00760000118955.
HOGENOMiHOG000261662.
HOVERGENiHBG057280.
InParanoidiQ9Y289.
KOiK14386.
OMAiCILQETS.
OrthoDBiEOG091G07OC.
PhylomeDBiQ9Y289.
TreeFamiTF316728.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 2 hits.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y289-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVGVSTSAP LSPTSGTSVG MSTFSIMDYV VFVLLLVLSL AIGLYHACRG
60 70 80 90 100
WGRHTVGELL MADRKMGCLP VALSLLATFQ SAVAILGVPS EIYRFGTQYW
110 120 130 140 150
FLGCCYFLGL LIPAHIFIPV FYRLHLTSAY EYLELRFNKT VRVCGTVTFI
160 170 180 190 200
FQMVIYMGVV LYAPSLALNA VTGFDLWLSV LALGIVCTVY TALGGLKAVI
210 220 230 240 250
WTDVFQTLVM FLGQLAVIIV GSAKVGGLGR VWAVASQHGR ISGFELDPDP
260 270 280 290 300
FVRHTFWTLA FGGVFMMLSL YGVNQAQVQR YLSSRTEKAA VLSCYAVFPF
310 320 330 340 350
QQVSLCVGCL IGLVMFAYYQ EYPMSIQQAQ AAPDQFVLYF VMDLLKGLPG
360 370 380 390 400
LPGLFIACLF SGSLSTISSA FNSLATVTME DLIRPWFPEF SEARAIMLSR
410 420 430 440 450
GLAFGYGLLC LGMAYISSQM GPVLQAAISI FGMVGGPLLG LFCLGMFFPC
460 470 480 490 500
ANPPGAVVGL LAGLVMAFWI GIGSIVTSMG SSMPPSPSNG SSFSLPTNLT
510 520 530 540 550
VATVTTLMPL TTFSKPTGLQ RFYSLSYLWY SAHNSTTVIV VGLIVSLLTG
560 570 580 590 600
RMRGRSLNPA TIYPVLPKLL SLLPLSCQKR LHCRSYGQDH LDTGLFPEKP
610 620 630
RNGVLGDSRD KEAMALDGTA YQGSSSTCIL QETSL
Length:635
Mass (Da):68,642
Last modified:May 5, 2009 - v2
Checksum:i52A6E40DB337134F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052491481S → F.4 PublicationsCorresponds to variant rs1395dbSNPEnsembl.1
Natural variantiVAR_052492492S → N.Corresponds to variant rs1064845dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF116241 Genomic DNA. Translation: AAD37502.1.
AF069307 mRNA. Translation: AAD31727.1.
AF081571 mRNA. Translation: AAD37481.1.
AK314545 mRNA. Translation: BAG37132.1.
AC013403 Genomic DNA. Translation: AAX93172.1.
CH471053 Genomic DNA. Translation: EAX00620.1.
CH471053 Genomic DNA. Translation: EAX00621.1.
CH471053 Genomic DNA. Translation: EAX00622.1.
BC012806 mRNA. Translation: AAH12806.1.
BC015631 mRNA. Translation: AAH15631.1.
CCDSiCCDS1740.1.
RefSeqiNP_066918.2. NM_021095.2.
XP_006712191.1. XM_006712128.1.
XP_006712192.1. XM_006712129.1.
XP_006712193.1. XM_006712130.1.
UniGeneiHs.435735.

Genome annotation databases

EnsembliENST00000310574; ENSP00000310208; ENSG00000138074.
ENST00000408041; ENSP00000384853; ENSG00000138074.
GeneIDi8884.
KEGGihsa:8884.
UCSCiuc002rjd.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF116241 Genomic DNA. Translation: AAD37502.1.
AF069307 mRNA. Translation: AAD31727.1.
AF081571 mRNA. Translation: AAD37481.1.
AK314545 mRNA. Translation: BAG37132.1.
AC013403 Genomic DNA. Translation: AAX93172.1.
CH471053 Genomic DNA. Translation: EAX00620.1.
CH471053 Genomic DNA. Translation: EAX00621.1.
CH471053 Genomic DNA. Translation: EAX00622.1.
BC012806 mRNA. Translation: AAH12806.1.
BC015631 mRNA. Translation: AAH15631.1.
CCDSiCCDS1740.1.
RefSeqiNP_066918.2. NM_021095.2.
XP_006712191.1. XM_006712128.1.
XP_006712192.1. XM_006712129.1.
XP_006712193.1. XM_006712130.1.
UniGeneiHs.435735.

3D structure databases

ProteinModelPortaliQ9Y289.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114403. 4 interactors.
IntActiQ9Y289. 2 interactors.
MINTiMINT-5005745.
STRINGi9606.ENSP00000310208.

Chemistry databases

DrugBankiDB00121. Biotin.
DB08872. gabapentin enacarbil.
DB00166. Lipoic Acid.

Protein family/group databases

TCDBi2.A.21.5.7. the solute:sodium symporter (sss) family.

PTM databases

iPTMnetiQ9Y289.
PhosphoSitePlusiQ9Y289.
SwissPalmiQ9Y289.

Polymorphism and mutation databases

BioMutaiSLC5A6.
DMDMi229462745.

Proteomic databases

EPDiQ9Y289.
MaxQBiQ9Y289.
PaxDbiQ9Y289.
PeptideAtlasiQ9Y289.
PRIDEiQ9Y289.

Protocols and materials databases

DNASUi8884.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310574; ENSP00000310208; ENSG00000138074.
ENST00000408041; ENSP00000384853; ENSG00000138074.
GeneIDi8884.
KEGGihsa:8884.
UCSCiuc002rjd.4. human.

Organism-specific databases

CTDi8884.
DisGeNETi8884.
GeneCardsiSLC5A6.
HGNCiHGNC:11041. SLC5A6.
HPAiHPA036958.
MIMi604024. gene.
neXtProtiNX_Q9Y289.
OpenTargetsiENSG00000138074.
PharmGKBiPA379.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2349. Eukaryota.
COG0591. LUCA.
GeneTreeiENSGT00760000118955.
HOGENOMiHOG000261662.
HOVERGENiHBG057280.
InParanoidiQ9Y289.
KOiK14386.
OMAiCILQETS.
OrthoDBiEOG091G07OC.
PhylomeDBiQ9Y289.
TreeFamiTF316728.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000138074-MONOMER.
ReactomeiR-HSA-196780. Biotin transport and metabolism.
R-HSA-199220. Vitamin B5 (pantothenate) metabolism.
R-HSA-425397. Transport of vitamins, nucleosides, and related molecules.

Miscellaneous databases

ChiTaRSiSLC5A6. human.
GeneWikiiSLC5A6.
GenomeRNAii8884.
PROiQ9Y289.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000138074.
CleanExiHS_SLC5A6.
ExpressionAtlasiQ9Y289. baseline and differential.
GenevisibleiQ9Y289. HS.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 2 hits.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSC5A6_HUMAN
AccessioniPrimary (citable) accession number: Q9Y289
Secondary accession number(s): B2RB85, D6W549, Q969Y5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 5, 2009
Last modified: November 2, 2016
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.