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Protein

Sodium-dependent multivitamin transporter

Gene

SLC5A6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transports pantothenate, biotin and lipoate in the presence of sodium.

GO - Molecular functioni

  • sodium-dependent multivitamin transmembrane transporter activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Biotin, Sodium

Enzyme and pathway databases

ReactomeiREACT_11153. Biotin transport and metabolism.
REACT_11172. Vitamin B5 (pantothenate) metabolism.
REACT_22285. Transport of vitamins, nucleosides, and related molecules.

Protein family/group databases

TCDBi2.A.21.5.7. the solute:sodium symporter (sss) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent multivitamin transporter
Short name:
Na(+)-dependent multivitamin transporter
Alternative name(s):
Solute carrier family 5 member 6
Gene namesi
Name:SLC5A6
Synonyms:SMVT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:11041. SLC5A6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei24 – 4421HelicalSequence AnalysisAdd
BLAST
Transmembranei68 – 8821HelicalSequence AnalysisAdd
BLAST
Transmembranei101 – 12121HelicalSequence AnalysisAdd
BLAST
Transmembranei143 – 16321HelicalSequence AnalysisAdd
BLAST
Transmembranei176 – 19621HelicalSequence AnalysisAdd
BLAST
Transmembranei199 – 21921HelicalSequence AnalysisAdd
BLAST
Transmembranei256 – 27621HelicalSequence AnalysisAdd
BLAST
Transmembranei297 – 31721HelicalSequence AnalysisAdd
BLAST
Transmembranei336 – 35621HelicalSequence AnalysisAdd
BLAST
Transmembranei396 – 41621HelicalSequence AnalysisAdd
BLAST
Transmembranei428 – 44821HelicalSequence AnalysisAdd
BLAST
Transmembranei456 – 47621HelicalSequence AnalysisAdd
BLAST
Transmembranei528 – 54821HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • brush border membrane Source: Ensembl
  • integral component of plasma membrane Source: ProtInc
  • membrane Source: ProtInc
  • plasma membrane Source: Reactome
  • vesicle membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA379.

Chemistry

DrugBankiDB00121. Biotin.
DB08872. gabapentin enacarbil.
DB00166. Lipoic Acid.

Polymorphism and mutation databases

BioMutaiSLC5A6.
DMDMi229462745.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 635635Sodium-dependent multivitamin transporterPRO_0000105386Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi138 – 1381N-linked (GlcNAc...)Sequence Analysis
Glycosylationi489 – 4891N-linked (GlcNAc...)Sequence Analysis
Glycosylationi498 – 4981N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9Y289.
PaxDbiQ9Y289.
PRIDEiQ9Y289.

PTM databases

PhosphoSiteiQ9Y289.

Expressioni

Gene expression databases

BgeeiQ9Y289.
CleanExiHS_SLC5A6.
ExpressionAtlasiQ9Y289. baseline and differential.
GenevisibleiQ9Y289. HS.

Organism-specific databases

HPAiHPA036958.

Interactioni

Protein-protein interaction databases

BioGridi114403. 3 interactions.
IntActiQ9Y289. 1 interaction.
MINTiMINT-5005745.
STRINGi9606.ENSP00000310208.

Structurei

3D structure databases

ProteinModelPortaliQ9Y289.
SMRiQ9Y289. Positions 25-470.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0591.
GeneTreeiENSGT00760000118955.
HOGENOMiHOG000261662.
HOVERGENiHBG057280.
InParanoidiQ9Y289.
KOiK14386.
OMAiPWFPQFS.
OrthoDBiEOG70PBX7.
PhylomeDBiQ9Y289.
TreeFamiTF316728.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
IPR019900. Na/solute_symporter_subgr.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 1 hit.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y289-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVGVSTSAP LSPTSGTSVG MSTFSIMDYV VFVLLLVLSL AIGLYHACRG
60 70 80 90 100
WGRHTVGELL MADRKMGCLP VALSLLATFQ SAVAILGVPS EIYRFGTQYW
110 120 130 140 150
FLGCCYFLGL LIPAHIFIPV FYRLHLTSAY EYLELRFNKT VRVCGTVTFI
160 170 180 190 200
FQMVIYMGVV LYAPSLALNA VTGFDLWLSV LALGIVCTVY TALGGLKAVI
210 220 230 240 250
WTDVFQTLVM FLGQLAVIIV GSAKVGGLGR VWAVASQHGR ISGFELDPDP
260 270 280 290 300
FVRHTFWTLA FGGVFMMLSL YGVNQAQVQR YLSSRTEKAA VLSCYAVFPF
310 320 330 340 350
QQVSLCVGCL IGLVMFAYYQ EYPMSIQQAQ AAPDQFVLYF VMDLLKGLPG
360 370 380 390 400
LPGLFIACLF SGSLSTISSA FNSLATVTME DLIRPWFPEF SEARAIMLSR
410 420 430 440 450
GLAFGYGLLC LGMAYISSQM GPVLQAAISI FGMVGGPLLG LFCLGMFFPC
460 470 480 490 500
ANPPGAVVGL LAGLVMAFWI GIGSIVTSMG SSMPPSPSNG SSFSLPTNLT
510 520 530 540 550
VATVTTLMPL TTFSKPTGLQ RFYSLSYLWY SAHNSTTVIV VGLIVSLLTG
560 570 580 590 600
RMRGRSLNPA TIYPVLPKLL SLLPLSCQKR LHCRSYGQDH LDTGLFPEKP
610 620 630
RNGVLGDSRD KEAMALDGTA YQGSSSTCIL QETSL
Length:635
Mass (Da):68,642
Last modified:May 5, 2009 - v2
Checksum:i52A6E40DB337134F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti481 – 4811S → F.4 Publications
Corresponds to variant rs1395 [ dbSNP | Ensembl ].
VAR_052491
Natural varianti492 – 4921S → N.
Corresponds to variant rs1064845 [ dbSNP | Ensembl ].
VAR_052492

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF116241 Genomic DNA. Translation: AAD37502.1.
AF069307 mRNA. Translation: AAD31727.1.
AF081571 mRNA. Translation: AAD37481.1.
AK314545 mRNA. Translation: BAG37132.1.
AC013403 Genomic DNA. Translation: AAX93172.1.
CH471053 Genomic DNA. Translation: EAX00620.1.
CH471053 Genomic DNA. Translation: EAX00621.1.
CH471053 Genomic DNA. Translation: EAX00622.1.
BC012806 mRNA. Translation: AAH12806.1.
BC015631 mRNA. Translation: AAH15631.1.
CCDSiCCDS1740.1.
RefSeqiNP_066918.2. NM_021095.2.
XP_006712191.1. XM_006712128.1.
XP_006712192.1. XM_006712129.1.
XP_006712193.1. XM_006712130.1.
UniGeneiHs.435735.

Genome annotation databases

EnsembliENST00000310574; ENSP00000310208; ENSG00000138074.
ENST00000408041; ENSP00000384853; ENSG00000138074.
GeneIDi8884.
KEGGihsa:8884.
UCSCiuc002rjd.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF116241 Genomic DNA. Translation: AAD37502.1.
AF069307 mRNA. Translation: AAD31727.1.
AF081571 mRNA. Translation: AAD37481.1.
AK314545 mRNA. Translation: BAG37132.1.
AC013403 Genomic DNA. Translation: AAX93172.1.
CH471053 Genomic DNA. Translation: EAX00620.1.
CH471053 Genomic DNA. Translation: EAX00621.1.
CH471053 Genomic DNA. Translation: EAX00622.1.
BC012806 mRNA. Translation: AAH12806.1.
BC015631 mRNA. Translation: AAH15631.1.
CCDSiCCDS1740.1.
RefSeqiNP_066918.2. NM_021095.2.
XP_006712191.1. XM_006712128.1.
XP_006712192.1. XM_006712129.1.
XP_006712193.1. XM_006712130.1.
UniGeneiHs.435735.

3D structure databases

ProteinModelPortaliQ9Y289.
SMRiQ9Y289. Positions 25-470.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114403. 3 interactions.
IntActiQ9Y289. 1 interaction.
MINTiMINT-5005745.
STRINGi9606.ENSP00000310208.

Chemistry

DrugBankiDB00121. Biotin.
DB08872. gabapentin enacarbil.
DB00166. Lipoic Acid.

Protein family/group databases

TCDBi2.A.21.5.7. the solute:sodium symporter (sss) family.

PTM databases

PhosphoSiteiQ9Y289.

Polymorphism and mutation databases

BioMutaiSLC5A6.
DMDMi229462745.

Proteomic databases

MaxQBiQ9Y289.
PaxDbiQ9Y289.
PRIDEiQ9Y289.

Protocols and materials databases

DNASUi8884.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310574; ENSP00000310208; ENSG00000138074.
ENST00000408041; ENSP00000384853; ENSG00000138074.
GeneIDi8884.
KEGGihsa:8884.
UCSCiuc002rjd.3. human.

Organism-specific databases

CTDi8884.
GeneCardsiGC02M027422.
HGNCiHGNC:11041. SLC5A6.
HPAiHPA036958.
MIMi604024. gene.
neXtProtiNX_Q9Y289.
PharmGKBiPA379.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0591.
GeneTreeiENSGT00760000118955.
HOGENOMiHOG000261662.
HOVERGENiHBG057280.
InParanoidiQ9Y289.
KOiK14386.
OMAiPWFPQFS.
OrthoDBiEOG70PBX7.
PhylomeDBiQ9Y289.
TreeFamiTF316728.

Enzyme and pathway databases

ReactomeiREACT_11153. Biotin transport and metabolism.
REACT_11172. Vitamin B5 (pantothenate) metabolism.
REACT_22285. Transport of vitamins, nucleosides, and related molecules.

Miscellaneous databases

ChiTaRSiSLC5A6. human.
GeneWikiiSLC5A6.
GenomeRNAii8884.
NextBioi33365.
PROiQ9Y289.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y289.
CleanExiHS_SLC5A6.
ExpressionAtlasiQ9Y289. baseline and differential.
GenevisibleiQ9Y289. HS.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
IPR019900. Na/solute_symporter_subgr.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 1 hit.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human placental Na+-dependent multivitamin transporter. Cloning, functional expression, gene structure, and chromosomal localization."
    Wang H., Huang W., Fei Y.-J., Xia H., Yang-Feng T.L., Leibach F.H., Devoe L.D., Ganapathy V., Prasad P.D.
    J. Biol. Chem. 274:14875-14883(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANT PHE-481.
    Tissue: Intestine.
  2. "Molecular and functional characterization of the intestinal Na+-dependent multivitamin transporter."
    Prasad P.D., Wang H., Huang W., Fei Y.-J., Leibach F.H., Devoe L.D., Ganapathy V.
    Arch. Biochem. Biophys. 366:95-106(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PHE-481.
    Tissue: Intestine.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-481.
    Tissue: Placenta.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PHE-481.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiSC5A6_HUMAN
AccessioniPrimary (citable) accession number: Q9Y289
Secondary accession number(s): B2RB85, D6W549, Q969Y5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 5, 2009
Last modified: July 22, 2015
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.