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Protein

Sialic acid-binding Ig-like lectin 7

Gene

SIGLEC7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei124Sialic acid2 Publications1

GO - Molecular functioni

  • carbohydrate binding Source: ProtInc
  • receptor activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Lectin

Enzyme and pathway databases

BioCyciZFISH:ENSG00000168995-MONOMER.
ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
Sialic acid-binding Ig-like lectin 7
Short name:
Siglec-7
Alternative name(s):
Adhesion inhibitory receptor molecule 1
Short name:
AIRM-1
CDw328
D-siglec
QA79 membrane protein
p75
CD_antigen: CD328
Gene namesi
Name:SIGLEC7
Synonyms:AIRM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:10876. SIGLEC7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 353ExtracellularSequence analysisAdd BLAST335
Transmembranei354 – 376HelicalSequence analysisAdd BLAST23
Topological domaini377 – 467CytoplasmicSequence analysisAdd BLAST91

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi27036.
OpenTargetsiENSG00000168995.
PharmGKBiPA35777.

Chemistry databases

ChEMBLiCHEMBL3603730.

Polymorphism and mutation databases

DMDMi25009269.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001494719 – 467Sialic acid-binding Ig-like lectin 7Add BLAST449

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi46 ↔ 106PROSITE-ProRule annotation4 Publications
Glycosylationi105N-linked (GlcNAc...)2 Publications1
Glycosylationi142N-linked (GlcNAc...)Sequence analysis1
Glycosylationi165N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi168 ↔ 217PROSITE-ProRule annotation
Glycosylationi229N-linked (GlcNAc...)Sequence analysis1
Glycosylationi235N-linked (GlcNAc...)Sequence analysis1
Glycosylationi242N-linked (GlcNAc...)Sequence analysis1
Glycosylationi260N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi276 ↔ 320PROSITE-ProRule annotation
Glycosylationi334N-linked (GlcNAc...)Sequence analysis1
Modified residuei429PhosphoserineCombined sources1

Post-translational modificationi

Tyrosine phosphorylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9Y286.
PeptideAtlasiQ9Y286.
PRIDEiQ9Y286.

PTM databases

iPTMnetiQ9Y286.
PhosphoSitePlusiQ9Y286.

Expressioni

Tissue specificityi

Predominantly expressed by resting and activated natural killer cells and at lower levels by granulocytes and monocytes. High expression found in placenta, liver, lung, spleen, and peripheral blood leukocytes.

Gene expression databases

BgeeiENSG00000168995.
CleanExiHS_SIGLEC7.
ExpressionAtlasiQ9Y286. baseline and differential.
GenevisibleiQ9Y286. HS.

Organism-specific databases

HPAiCAB025154.

Interactioni

Subunit structurei

Interacts with PTPN6/SHP-1 upon phosphorylation.3 Publications

Protein-protein interaction databases

BioGridi117967. 5 interactors.
IntActiQ9Y286. 1 interactor.
STRINGi9606.ENSP00000323328.

Structurei

Secondary structure

1467
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi23 – 25Combined sources3
Beta strandi27 – 30Combined sources4
Beta strandi32 – 37Combined sources6
Beta strandi42 – 44Combined sources3
Beta strandi46 – 49Combined sources4
Turni54 – 58Combined sources5
Beta strandi62 – 67Combined sources6
Beta strandi69 – 71Combined sources3
Helixi72 – 74Combined sources3
Beta strandi78 – 81Combined sources4
Helixi85 – 88Combined sources4
Helixi89 – 91Combined sources3
Turni92 – 94Combined sources3
Beta strandi95 – 97Combined sources3
Helixi101 – 103Combined sources3
Beta strandi108 – 110Combined sources3
Helixi115 – 117Combined sources3
Beta strandi119 – 127Combined sources9
Beta strandi130 – 133Combined sources4
Beta strandi139 – 144Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NKOX-ray1.45A19-150[»]
1O7SX-ray1.75A18-144[»]
1O7VX-ray1.90A18-144[»]
2DF3X-ray1.90A18-144[»]
2G5RX-ray1.60A18-144[»]
2HRLX-ray1.85A18-144[»]
ProteinModelPortaliQ9Y286.
SMRiQ9Y286.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y286.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 122Ig-like V-typeAdd BLAST84
Domaini150 – 233Ig-like C2-type 1Add BLAST84
Domaini240 – 336Ig-like C2-type 2Add BLAST97

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni131 – 135Sialic acid binding3 Publications5

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi435 – 440ITIM motif6

Domaini

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJT6. Eukaryota.
ENOG410YKZU. LUCA.
GeneTreeiENSGT00760000119139.
HOGENOMiHOG000236324.
HOVERGENiHBG036161.
InParanoidiQ9Y286.
KOiK06739.
OMAiFQGEGTA.
OrthoDBiEOG091G0445.
PhylomeDBiQ9Y286.
TreeFamiTF332441.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y286-1) [UniParc]FASTAAdd to basket
Also known as: AIRM-1b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLLLLLPLL WGRERVEGQK SNRKDYSLTM QSSVTVQEGM CVHVRCSFSY
60 70 80 90 100
PVDSQTDSDP VHGYWFRAGN DISWKAPVAT NNPAWAVQEE TRDRFHLLGD
110 120 130 140 150
PQTKNCTLSI RDARMSDAGR YFFRMEKGNI KWNYKYDQLS VNVTALTHRP
160 170 180 190 200
NILIPGTLES GCFQNLTCSV PWACEQGTPP MISWMGTSVS PLHPSTTRSS
210 220 230 240 250
VLTLIPQPQH HGTSLTCQVT LPGAGVTTNR TIQLNVSYPP QNLTVTVFQG
260 270 280 290 300
EGTASTALGN SSSLSVLEGQ SLRLVCAVDS NPPARLSWTW RSLTLYPSQP
310 320 330 340 350
SNPLVLELQV HLGDEGEFTC RAQNSLGSQH VSLNLSLQQE YTGKMRPVSG
360 370 380 390 400
VLLGAVGGAG ATALVFLSFC VIFIVVRSCR KKSARPAADV GDIGMKDANT
410 420 430 440 450
IRGSASQGNL TESWADDNPR HHGLAAHSSG EEREIQYAPL SFHKGEPQDL
460
SGQEATNNEY SEIKIPK
Length:467
Mass (Da):51,143
Last modified:November 1, 1999 - v1
Checksum:i8AFE44462B001F52
GO
Isoform 2 (identifier: Q9Y286-2) [UniParc]FASTAAdd to basket
Also known as: AIRM-2

The sequence of this isoform differs from the canonical sequence as follows:
     145-238: ALTHRPNILI...NRTIQLNVSY → D

Show »
Length:374
Mass (Da):41,237
Checksum:i4E37C43130E19527
GO
Isoform 3 (identifier: Q9Y286-3) [UniParc]FASTAAdd to basket
Also known as: AIRM-3

The sequence of this isoform differs from the canonical sequence as follows:
     145-145: A → E
     146-467: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:145
Mass (Da):16,812
Checksum:iB2754D9627528108
GO
Isoform 4 (identifier: Q9Y286-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     145-145: A → G
     146-467: Missing.

Note: No experimental confirmation available.
Show »
Length:145
Mass (Da):16,740
Checksum:iB1154D9627528108
GO

Sequence cautioni

The sequence AAF44346 differs from that shown. Reason: Frameshift at position 406.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti42V → A in AAF44346 (PubMed:10764831).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035523215L → P in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_002555145 – 238ALTHR…LNVSY → D in isoform 2. 3 PublicationsAdd BLAST94
Alternative sequenceiVSP_002556145A → E in isoform 3. 1 Publication1
Alternative sequenceiVSP_002557145A → G in isoform 4. 1 Publication1
Alternative sequenceiVSP_002558146 – 467Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST322

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF170485 mRNA. Translation: AAF12759.1.
AJ007395 mRNA. Translation: CAB46011.1.
AJ130710 mRNA. Translation: CAB51126.1.
AJ130711 mRNA. Translation: CAB51127.1.
AJ130712 mRNA. Translation: CAB51128.1.
AJ130713 mRNA. Translation: CAB51129.1.
AF178981 mRNA. Translation: AAF44346.1. Frameshift.
AF193441 mRNA. Translation: AAF06790.1.
CCDSiCCDS12826.1. [Q9Y286-1]
CCDS42601.1. [Q9Y286-2]
CCDS62771.1. [Q9Y286-4]
RefSeqiNP_001264130.1. NM_001277201.1. [Q9Y286-4]
NP_055200.1. NM_014385.3. [Q9Y286-1]
NP_057627.2. NM_016543.3. [Q9Y286-2]
UniGeneiHs.655393.

Genome annotation databases

EnsembliENST00000305628; ENSP00000306757; ENSG00000168995. [Q9Y286-2]
ENST00000317643; ENSP00000323328; ENSG00000168995. [Q9Y286-1]
ENST00000536156; ENSP00000437609; ENSG00000168995. [Q9Y286-3]
ENST00000600577; ENSP00000472529; ENSG00000168995. [Q9Y286-4]
GeneIDi27036.
KEGGihsa:27036.
UCSCiuc002pvv.1. human. [Q9Y286-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Siglec-7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF170485 mRNA. Translation: AAF12759.1.
AJ007395 mRNA. Translation: CAB46011.1.
AJ130710 mRNA. Translation: CAB51126.1.
AJ130711 mRNA. Translation: CAB51127.1.
AJ130712 mRNA. Translation: CAB51128.1.
AJ130713 mRNA. Translation: CAB51129.1.
AF178981 mRNA. Translation: AAF44346.1. Frameshift.
AF193441 mRNA. Translation: AAF06790.1.
CCDSiCCDS12826.1. [Q9Y286-1]
CCDS42601.1. [Q9Y286-2]
CCDS62771.1. [Q9Y286-4]
RefSeqiNP_001264130.1. NM_001277201.1. [Q9Y286-4]
NP_055200.1. NM_014385.3. [Q9Y286-1]
NP_057627.2. NM_016543.3. [Q9Y286-2]
UniGeneiHs.655393.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NKOX-ray1.45A19-150[»]
1O7SX-ray1.75A18-144[»]
1O7VX-ray1.90A18-144[»]
2DF3X-ray1.90A18-144[»]
2G5RX-ray1.60A18-144[»]
2HRLX-ray1.85A18-144[»]
ProteinModelPortaliQ9Y286.
SMRiQ9Y286.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117967. 5 interactors.
IntActiQ9Y286. 1 interactor.
STRINGi9606.ENSP00000323328.

Chemistry databases

ChEMBLiCHEMBL3603730.

PTM databases

iPTMnetiQ9Y286.
PhosphoSitePlusiQ9Y286.

Polymorphism and mutation databases

DMDMi25009269.

Proteomic databases

PaxDbiQ9Y286.
PeptideAtlasiQ9Y286.
PRIDEiQ9Y286.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305628; ENSP00000306757; ENSG00000168995. [Q9Y286-2]
ENST00000317643; ENSP00000323328; ENSG00000168995. [Q9Y286-1]
ENST00000536156; ENSP00000437609; ENSG00000168995. [Q9Y286-3]
ENST00000600577; ENSP00000472529; ENSG00000168995. [Q9Y286-4]
GeneIDi27036.
KEGGihsa:27036.
UCSCiuc002pvv.1. human. [Q9Y286-1]

Organism-specific databases

CTDi27036.
DisGeNETi27036.
GeneCardsiSIGLEC7.
H-InvDBHIX0040323.
HGNCiHGNC:10876. SIGLEC7.
HPAiCAB025154.
MIMi604410. gene.
neXtProtiNX_Q9Y286.
OpenTargetsiENSG00000168995.
PharmGKBiPA35777.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJT6. Eukaryota.
ENOG410YKZU. LUCA.
GeneTreeiENSGT00760000119139.
HOGENOMiHOG000236324.
HOVERGENiHBG036161.
InParanoidiQ9Y286.
KOiK06739.
OMAiFQGEGTA.
OrthoDBiEOG091G0445.
PhylomeDBiQ9Y286.
TreeFamiTF332441.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000168995-MONOMER.
ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

EvolutionaryTraceiQ9Y286.
GeneWikiiSIGLEC7.
GenomeRNAii27036.
PROiQ9Y286.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168995.
CleanExiHS_SIGLEC7.
ExpressionAtlasiQ9Y286. baseline and differential.
GenevisibleiQ9Y286. HS.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSIGL7_HUMAN
AccessioniPrimary (citable) accession number: Q9Y286
Secondary accession number(s): Q9NZQ1
, Q9UJ86, Q9UJ87, Q9Y502
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: November 1, 1999
Last modified: November 30, 2016
This is version 156 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.