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Q9Y284

- ASTER_HUMAN

UniProt

Q9Y284 - ASTER_HUMAN

Protein

Protein Asterix

Gene

WDR83OS

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein Asterix
    Alternative name(s):
    WD repeat domain 83 opposite strand
    WDR83 opposite strand
    Gene namesi
    Name:WDR83OS
    Synonyms:C19orf56
    ORF Names:CGI-140, My006, PTD008
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:30203. WDR83OS.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162378666.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 106105Protein AsterixPRO_0000071605Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9Y284.
    PaxDbiQ9Y284.
    PRIDEiQ9Y284.

    PTM databases

    PhosphoSiteiQ9Y284.

    Expressioni

    Gene expression databases

    BgeeiQ9Y284.
    CleanExiHS_C19orf56.
    GenevestigatoriQ9Y284.

    Interactioni

    Protein-protein interaction databases

    BioGridi119522. 1 interaction.
    IntActiQ9Y284. 1 interaction.
    STRINGi9606.ENSP00000222190.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y284.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei40 – 6223HelicalSequence AnalysisAdd
    BLAST
    Transmembranei80 – 9617HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Asterix family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG317543.
    HOGENOMiHOG000007025.
    HOVERGENiHBG000507.
    InParanoidiQ9Y284.
    OMAiLYCSCIS.
    OrthoDBiEOG7MSMR4.
    PhylomeDBiQ9Y284.
    TreeFamiTF315003.

    Family and domain databases

    InterProiIPR005351. UPF0139.
    [Graphical view]
    PANTHERiPTHR13193. PTHR13193. 1 hit.
    PfamiPF03669. UPF0139. 1 hit.
    [Graphical view]
    ProDomiPD073147. UPF0139. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9Y284-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTNNMSDPR RPNKVLRYKP PPSECNPALD DPTPDYMNLL GMIFSMCGLM    50
    LKLKWCAWVA VYCSFISFAN SRSSEDTKQM MSSFMLSISA VVMSYLQNPQ 100
    PMTPPW 106
    Length:106
    Mass (Da):12,068
    Last modified:November 1, 1999 - v1
    Checksum:i7D2BDDAF9279071B
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti104 – 1041P → A.
    Corresponds to variant rs3209404 [ dbSNP | Ensembl ].
    VAR_052498

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF059620 mRNA. Translation: AAG43119.1.
    AF078861 mRNA. Translation: AAD44493.1.
    AF151898 mRNA. Translation: AAD34135.1.
    AK311944 mRNA. Translation: BAG34885.1.
    CH471106 Genomic DNA. Translation: EAW84285.1.
    BC001192 mRNA. Translation: AAH01192.1.
    BC042919 mRNA. Translation: AAH42919.1.
    BC061912 mRNA. Translation: AAH61912.1.
    CCDSiCCDS12274.1.
    RefSeqiNP_057229.1. NM_016145.3.
    UniGeneiHs.108969.
    Hs.657204.

    Genome annotation databases

    EnsembliENST00000596731; ENSP00000468969; ENSG00000105583.
    GeneIDi51398.
    KEGGihsa:51398.
    UCSCiuc002mud.2. human.

    Polymorphism databases

    DMDMi12585211.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF059620 mRNA. Translation: AAG43119.1 .
    AF078861 mRNA. Translation: AAD44493.1 .
    AF151898 mRNA. Translation: AAD34135.1 .
    AK311944 mRNA. Translation: BAG34885.1 .
    CH471106 Genomic DNA. Translation: EAW84285.1 .
    BC001192 mRNA. Translation: AAH01192.1 .
    BC042919 mRNA. Translation: AAH42919.1 .
    BC061912 mRNA. Translation: AAH61912.1 .
    CCDSi CCDS12274.1.
    RefSeqi NP_057229.1. NM_016145.3.
    UniGenei Hs.108969.
    Hs.657204.

    3D structure databases

    ProteinModelPortali Q9Y284.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119522. 1 interaction.
    IntActi Q9Y284. 1 interaction.
    STRINGi 9606.ENSP00000222190.

    PTM databases

    PhosphoSitei Q9Y284.

    Polymorphism databases

    DMDMi 12585211.

    Proteomic databases

    MaxQBi Q9Y284.
    PaxDbi Q9Y284.
    PRIDEi Q9Y284.

    Protocols and materials databases

    DNASUi 51398.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000596731 ; ENSP00000468969 ; ENSG00000105583 .
    GeneIDi 51398.
    KEGGi hsa:51398.
    UCSCi uc002mud.2. human.

    Organism-specific databases

    CTDi 51398.
    GeneCardsi GC19M012779.
    H-InvDB HIX0014794.
    HGNCi HGNC:30203. WDR83OS.
    neXtProti NX_Q9Y284.
    PharmGKBi PA162378666.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG317543.
    HOGENOMi HOG000007025.
    HOVERGENi HBG000507.
    InParanoidi Q9Y284.
    OMAi LYCSCIS.
    OrthoDBi EOG7MSMR4.
    PhylomeDBi Q9Y284.
    TreeFami TF315003.

    Miscellaneous databases

    GenomeRNAii 51398.
    NextBioi 54933.
    PROi Q9Y284.

    Gene expression databases

    Bgeei Q9Y284.
    CleanExi HS_C19orf56.
    Genevestigatori Q9Y284.

    Family and domain databases

    InterProi IPR005351. UPF0139.
    [Graphical view ]
    PANTHERi PTHR13193. PTHR13193. 1 hit.
    Pfami PF03669. UPF0139. 1 hit.
    [Graphical view ]
    ProDomi PD073147. UPF0139. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. Mao Y.M., Xie Y., Zhou Z.X.
      Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Fetal brain.
    2. Song H., Peng Y., Dai M., Huang Q., Mao Y., Zhang Q., Mao M., Fu G., Luo M., Chen J., Hu R.
      Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pituitary tumor.
    3. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
      Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
      Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Small intestine.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye, Liver and Prostate.
    7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiASTER_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y284
    Secondary accession number(s): B2R4T8, Q9BVI3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2001
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3