Q9Y284 (ASTER_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein Asterix

Alternative name(s):
WD repeat domain 83 opposite strand
WDR83 opposite strand

Gene names

Name:	WDR83OS
ORF Names:	C19orf56, CGI-140, My006, PTD008

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	106 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the Asterix family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 106	106	Protein Asterix		PRO_0000071605
Regions
	Transmembrane	40 – 62	23	Helical; Potential
	Transmembrane	80 – 96	17	Helical; Potential
Natural variations
	Natural variant	104	1	P → A. Corresponds to variant rs3209404 [ dbSNP | Ensembl ].		VAR_052498

Sequences

	Sequence		Length	Mass (Da)
	Q9Y284 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 7D2BDDAF9279071B	FASTA	106	12,068
	10 20 30 40 50 60 MSTNNMSDPR RPNKVLRYKP PPSECNPALD DPTPDYMNLL GMIFSMCGLM LKLKWCAWVA 70 80 90 100 VYCSFISFAN SRSSEDTKQM MSSFMLSISA VVMSYLQNPQ PMTPPW

References

[1]	Mao Y.M., Xie Y., Zhou Z.X. Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Fetal brain.
[2]	Song H., Peng Y., Dai M., Huang Q., Mao Y., Zhang Q., Mao M., Fu G., Luo M., Chen J., Hu R. Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pituitary tumor.
[3]	"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics." Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C. Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Small intestine.
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye, Liver and Prostate.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF059620 mRNA. Translation: AAG43119.1. AF078861 mRNA. Translation: AAD44493.1. AF151898 mRNA. Translation: AAD34135.1. AK311944 mRNA. Translation: BAG34885.1. CH471106 Genomic DNA. Translation: EAW84285.1. BC001192 mRNA. Translation: AAH01192.1. BC042919 mRNA. Translation: AAH42919.1. BC061912 mRNA. Translation: AAH61912.1.
IPI	IPI00031819.
RefSeq	NP_057229.1. NM_016145.3.
UniGene	Hs.108969. Hs.657204.
3D structure databases
ProteinModelPortal	Q9Y284.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y284. 1 interaction.
STRING	9606.ENSP00000222190.
PTM databases
PhosphoSite	Q9Y284.
Polymorphism databases
DMDM	12585211.
Proteomic databases
PaxDb	Q9Y284.
PRIDE	Q9Y284.
Protocols and materials databases
DNASU	51398.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000596731; ENSP00000468969; ENSG00000105583.
GeneID	51398.
KEGG	hsa:51398.
UCSC	uc002mud.2. human.
Organism-specific databases
CTD	51398.
GeneCards	GC19M012779.
H-InvDB	HIX0014794.
HGNC	HGNC:30203. WDR83OS.
neXtProt	NX_Q9Y284.
PharmGKB	PA162378666.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG317543.
HOGENOM	HOG000007025.
HOVERGEN	HBG000507.
InParanoid	Q9Y284.
OMA	CSCISFA.
OrthoDB	EOG4C2HBS.
PhylomeDB	Q9Y284.
Gene expression databases
Bgee	Q9Y284.
CleanEx	HS_C19orf56.
Genevestigator	Q9Y284.
GermOnline	ENSG00000105583. Homo sapiens.
Family and domain databases
InterPro	IPR005351. UPF0139. [Graphical view]
PANTHER	PTHR13193. PTHR13193. 1 hit.
Pfam	PF03669. UPF0139. 1 hit. [Graphical view]
ProDom	PD073147. UPF0139. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...
Other
GenomeRNAi	51398.
NextBio	54933.

Entry information

Entry name

ASTER_HUMAN

Accession

Primary (citable) accession number: Q9Y284
Secondary accession number(s): B2R4T8, Q9BVI3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2001
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.